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### Appendix: for ewa
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- plugins tests (requirements):
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- disease association (*LRRK2 at leat 2x; PRKN at leat 1x*);
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- exploration (*check on element TFAM in advanced map*)
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* At least 1 species (S) in multiple compartments and multiple submaps (including the main map).
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* The depth of the exploration tree starting in S should be at least 2
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* S should be connected to the neighbours as reactant, product and modifier
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* S should be involved in reactions which are of type inhibition, negative influence and anything else from {inhibition, unknown inhibition, negative influence, unknown negative influence}
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- guide;
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- GSEA (*check on advanced map*)
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* Existence of two overlays (such as PD substantia nigra)
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* One should cover about 50% of at least two pathways, so that the pathways show as enriched. One of the pathways should be in a submap and one in the main map
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* The other should cover at least 50% of a pathway which is not covered by the first overlay |