ReactionPubmed idsOntologiesInputModifierOutput
re1067
21151032 

PINK1 / Parkin Pathway
cytosol
SNCAIP
[Q9Y6H5
PARK2
[O60260
SNCAIP
[Q9Y6H5
re1069
17027339 

PINK1 / Parkin Pathway
cytosol
Alpha tubulin
[] 
PARK2
[O60260
Alpha tubulin
[] 
re1070
17027339 

PINK1 / Parkin Pathway
cytosol
SEPT5
[Q99719
PARK2
[O60260
SEPT5
[Q99719
re1072
17027339 

PINK1 / Parkin Pathway
cytosol
GPR37
[O15354
PARK2
[O60260
GPR37
[O15354
re1073
17027339 

PINK1 / Parkin Pathway
cytosol
SYT11
[Q9BT88
PARK2
[O60260
SYT11
[Q9BT88
re1074
17027339 

PINK1 / Parkin Pathway
cytosol
Beta tubulin
[] 
PARK2
[O60260
Beta tubulin
[] 
re1075
17027339 

PINK1 / Parkin Pathway
cytosol
cyclin E
[P24864, O96020
PARK2
[O60260
cyclin E (ubiquitinated)
[P24864, O96020
re1076
17027339 

PINK1 / Parkin Pathway
cytosol
RANBP2
[P49792
PARK2
[O60260
RANBP2
[P49792
re1077
17027339 

PINK1 / Parkin Pathway
cytosol
AIMP2
[Q13155
PARK2
[O60260
AIMP2
[Q13155
re1078
17027339 

PINK1 / Parkin Pathway
cytosol
FUBP1
[Q96AE4
PARK2
[O60260
FUBP1
[Q96AE4
re1079
17027339 

PINK1 / Parkin Pathway
cytosol
SIM2
[Q14190
PARK2
[O60260
SIM2
[Q14190
re1080
17027339 

PINK1 / Parkin Pathway
cytosol
SLC6A3
[Q01959
PARK2
[O60260
SLC6A3
[Q01959
re1081
17027339 

PINK1 / Parkin Pathway
cytosol
SNCA
[P37840
PARK2
[O60260
SNCA
[P37840
re1082
21258367 

Calcium Signalling
cytosol
ATG1 kinase complex
[O75143, Q8TDY2, Q9BSB4, O75385
AMPK
[Q9Y478, Q9UGJ0, P54646, Q9UGI9, O43741, P54619, Q13131
ULK1 complex
[O75143, Q8TDY2, Q9BSB4, O75385
re1083
11038192 

16025099 

mitochondrial outer membrane
PINK1 / Parkin Pathway
mitochondrial inner membrane
cytosol
DNM1L
[O00429
 mitochondrial fission
[] 
re1084
16025099 

mitochondrial outer membrane
PINK1 / Parkin Pathway
mitochondrial inner membrane
cytosol
OPA1
[O60313
 mitochondrial fusion
[] 
re1085
17553808 

21339790 

17721437 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
DNM1L
[O00429
cAMP/cGMP-dependent protein kinase
[] 
DNM1L
[O00429
re1087
16025099 

mitochondrial outer membrane
PINK1 / Parkin Pathway
mitochondrial inner membrane
cytosol
MFN1
[Q8IWA4
 mitochondrial fusion
[] 
re1088
16025099 

mitochondrial outer membrane
PINK1 / Parkin Pathway
mitochondrial inner membrane
cytosol
MFN2
[O95140
 mitochondrial fusion
[] 
re1091
18838687 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
DNM1L
[O00429
Calcinuerin
[P16298, P48454, Q08209, Q96LZ3, P63098
DNM1L
[O00429
re1092
19407830 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
DNM1L
[O00429
MUL1
[Q969V5
DNM1L
[O00429
re1093
11038192 

16025099 

mitochondrial outer membrane
PINK1 / Parkin Pathway
mitochondrial inner membrane
cytosol
DNM1L
[O00429
 mitochondrial fission
[] 
re1095
20842175 

Calcium Signalling
cytosol
nucleus
NELF:importin alpha
[] 
 NSMF
[],
Importin subunit alpha
[] 
re1096
21115803 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
PINK1
[Q9BXM7
TOM complex
[Q96B49, O94826, O96008, Q9P0U1, Q15388, Q8N4H5, Q9NS69
PINK1
[Q9BXM7
re1097
21115803 

mitochondrial outer membrane
PINK1 / Parkin Pathway
mitochondrial inner membrane
cytosol
PINK1
[Q9BXM7
TIM Complex
[O60830, O43615, Q99595, O14925, Q3ZCQ8],
mitochondrial depolarization
[] 
PINK1
[Q9BXM7
re1098
21115803 

22354088 

mitochondrial outer membrane
PINK1 / Parkin Pathway
mitochondrial inner membrane
cytosol
PINK1
[Q9BXM7
PARL
[Q9H300],
PMPCA
[Q10713],
PMPCB
[O75439
s2004
[] 
re1099
21115803 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
PINK1
[Q9BXM7
 PINK1
[Q9BXM7
re1100
19029340 

mitochondrial outer membrane
Mitochondrial Electron Transport Chain
cytosol
CCCP
[] 
 mitochondrial depolarization
[] 
re1102
15297626 

mitochondrial outer membrane
PINK1 / Parkin Pathway
mitochondrial inner membrane
cytosol
mitochondrial depolarization
[] 
 mitochondrial fission
[] 
re1103
15297626 

16025099 

mitochondrial outer membrane
PINK1 / Parkin Pathway
mitochondrial inner membrane
cytosol
mitochondrial depolarization
[] 
 mitochondrial fusion
[] 
re1104
21173115 

21615408 

20871098 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
MFN1
[Q8IWA4
PINK1:PARK2
[O60260, Q9BXM7
MFN1
[Q8IWA4
re1105
21292769 

PINK1 / Parkin Pathway
cytosol
DNM1L
[O00429
PARK2
[O60260
DNM1L
[O00429
re1106
21173115 

20871098 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
MFN2
[O95140
PINK1:PARK2
[O60260, Q9BXM7
MFN2
[O95140
re114
19427899 

15734681 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
ADP
[CHEBI:16761],
H+
[CHEBI:15378
F0F1-ATP synthase (complex V)
[P36542, P48201, P25705, O75947, P30049, Q06055, P56385, O75964, P00846, P48047, Q9UII2, Q7Z4Y8, P05496, P06576, Q5VTU8, P56381, P03928, P18859, P56134, P24539
ATP
[CHEBI:15422],
H+
[CHEBI:15378
re116
17558391 

Calcium Signalling
cytosol
Ca2+
[CHEBI:29108
CACNA1D
[Q01668
Ca2+
[CHEBI:29108
re1198
19427899 

cytosolO2
[CHEBI:15379
 superoxide
[CHEBI:18421
re1199
19427899 

ROS Metabolism
cytosol
superoxide
[CHEBI:18421],
H+
[CHEBI:15378
SOD1
[P00441
hydrogen peroxide
[CHEBI:16240
re120
19427899 

mitochondrial outer membrane
mitochondrial inner membrane
cytosol
Ca2+
[CHEBI:29108
 ROS
[CHEBI:26523
re1200
19427899 

ROS Metabolism
cytosol
hydrogen peroxide
[CHEBI:16240
CAT
[P04040
H2O
[CHEBI:15377],
O2
[CHEBI:15379
re1201
19427899 

23939310 

ROS Metabolism
cytosol
hydrogen peroxide
[CHEBI:16240],
TXN
[P10599
PRDX1
[Q06830],
PRDX2
[P32119],
PRDX5
[P30044],
PRDX6
[P30041
H2O
[CHEBI:15377],
TXN
[P10599
re1202
19427899 

ROS Metabolism
cytosol
TXN
[P10599],
NADPH
[CHEBI:16474
TXNRD2
[Q9NNW7],
TXNRD1
[Q16881
TXN
[P10599],
NADP(+)
[CHEBI:18009
re1203
19427899 

ROS Metabolism
cytosol
hydrogen peroxide
[CHEBI:16240],
glutathione
[CHEBI:16856
GPX1
[P07203],
GPX4
[P36969
H2O
[CHEBI:15377],
glutathione disulfide
[CHEBI:17858
re1204
19427899 

ROS Metabolism
cytosol
glutathione disulfide
[CHEBI:17858],
NADPH
[CHEBI:16474
GSR
[P00390
glutathione
[CHEBI:16856],
NADP(+)
[CHEBI:18009
re1205
20045723 

cytosolsuperoxide
[CHEBI:18421
 ROS
[CHEBI:26523
re1206
20045723 

ROS Metabolism
cytosol
hydrogen peroxide
[CHEBI:16240
 ROS
[CHEBI:26523
re1207
2172697 

ROS Metabolism
cytosol
hydrogen peroxide
[CHEBI:16240],
Fe2+
[] 
 hydroxide
[CHEBI:16234],
Fe3+
[],
hydroxyl
[CHEBI:29191
re1208
20045723 

ROS Metabolism
cytosol
hydroxyl
[CHEBI:29191
 ROS
[CHEBI:26523
re1209
2172697 

ROS Metabolism
cytosol
hydroxyl
[CHEBI:29191],
Fe2+
[] 
 hydroxide
[CHEBI:16234],
Fe3+
[] 
re1210
2172697 

ROS Metabolism
cytosol
hydrogen peroxide
[CHEBI:16240],
hydroxyl
[CHEBI:29191
 superoxide
[CHEBI:18421],
H2O
[CHEBI:15377],
H+
[CHEBI:15378
re1211
2172697 

ROS Metabolism
cytosol
superoxide
[CHEBI:18421],
Fe3+
[] 
 O2
[CHEBI:15379],
Fe2+
[],
H+
[CHEBI:15378
re1212
20045723 

ROS Metabolism
cytosol
hydrogen peroxide
[CHEBI:16240
 ROS
[CHEBI:26523
re1213
20045723 

ROS Metabolism
cytosol
superoxide
[CHEBI:18421
 ROS
[CHEBI:26523
re1214
21658599 

20203611 

mitochondrial outer membrane
mitochondrial inner membrane
Fatty Acid / Ketone Body Metabolism
cytosol
ACADL
[P28330
SIRT3
[Q9NTG7
ACADL
[P28330
re1215
21658599 

20203611 

mitochondrial outer membrane
mitochondrial inner membrane
Fatty Acid / Ketone Body Metabolism
cytosol
ACADL
[P28330
SIRT3
[Q9NTG7
ACADL
[P28330
re1217
10878378 

19629069 

10837071 

Inflammation Signalling / Apoptosis
cytosol
IKK complex
[O15111, Q9Y6K9, O14920
MAP3K7
[O43318],
ROS
[CHEBI:26523
IKK complex
[O15111, Q9Y6K9, O14920
re1218
16724054 

Inflammation Signalling / Apoptosis
cytosol
NFKBIA
[P25963
UPS
[] 
s2522
[] 
re1220
10837071 

Inflammation Signalling / Apoptosis
cytosol
NF- kappa B:I kappa B
[P25963, P19838, Q04206
IKK complex
[O15111, Q9Y6K9, O14920
NF-kappa B:I kappa B
[P25963, P19838, Q04206
re1221
16724054 

Inflammation Signalling / Apoptosis
cytosol
NF-kappa B:I kappa B
[P25963, P19838, Q04206
 NF-kappa B
[P19838, Q04206],
NFKBIA
[P25963
re1224
10837071 

Inflammation Signalling / Apoptosis
cytosol
NF-kappa B:I kappa B
[P25963, P19838, Q04206
BTRC
[Q9Y297
NF-kappa B:I kappa B
[P25963, P19838, Q04206
re1225
10602459 

Inflammation Signalling / Apoptosis
cytosol
NFKB1
[P19838],
RELA
[Q04206],
NFKBIA
[P25963
 NF- kappa B:I kappa B
[P25963, P19838, Q04206
re1227
20303880 

cytosolIL1 receptor
[P27930, P14778
IL1B
[P01584
IL1 receptor
[P27930, P14778
re1228
23334208 

20303880 

cytosolTNFRSF1A
[P19438
TNF
[P01375
TNFRSF1A
[P19438
re1230
16724054 

Inflammation Signalling / Apoptosis
cytosol
TNFRSF1A
[P19438
 MAP3K7
[O43318
re1231
20303880 

microglia
Microglia
TNF
[P01375
 TNF
[P01375
re1232
20303880 

Astrocyte
astrocyte
TNF
[P01375
 TNF
[P01375
re1233
20303880 

microglia
Microglia
IL1B
[P01584
 IL1B
[P01584
re1234
20303880 

Astrocyte
astrocyte
IL1B
[P01584
 IL1B
[P01584
re1235
20303880 

microglia
Microglia
NADPH oxidase complex
[P04839, P14598, Q9HBY0
 superoxide
[CHEBI:18421
re1236
20303880 

Astrocyte
astrocyte
NADPH oxidase complex
[P04839, P14598, Q9HBY0
 ROS
[CHEBI:26523
re1239
20303880 

Inflammation Signalling / Apoptosis
cytosol
ROS
[CHEBI:26523
 ROS
[CHEBI:26523
re1242
20303880 

microglia
Microglia
PTGS2
[P35354
 prostaglandin E2
[CHEBI:15551
re1243
20303880 

microglia
Microglia
prostaglandin E2
[CHEBI:15551
 prostaglandin E2
[CHEBI:15551
re1244
20303880 

microglia
Microglia
IL6
[P05231
 IL6
[P05231
re1245
20303880 

Astrocyte
astrocyte
FASLG
[P48023
 FASLG
[P48023
re1246
21326199 

18288109 

mitochondrial outer membrane
Apoptosis
cytosol
HTRA2
[O43464
HAX1:PARL
[Q9H300, O00165
HTRA2
[O43464
re1250
20961626 

Alpha-synuclein / Lewy Bodies
Lewy body
cytosol
misfolded
[P37840
 misfolded
[P37840
re1251
20961626 

Alpha-synuclein / Lewy Bodies
Lewy body
cytosol
protofibril
[P37840
 protofibril
[P37840
re1252
20844148 

21772323 

Alpha-synuclein / Lewy Bodies
lysosome
cytosol
lysosome organization
[] 
 lysosome
[] 
re1253
20844148 

21772323 

Alpha-synuclein / Lewy Bodies
cytosol
rapamycin
[] 
 lysosome organization
[] 
re1254
21772323 

Alpha-synuclein / Lewy Bodies
Lewy body
lysosome
autolysosome
cytosol
lysosome
[],
Lewy Body
[] 
 Autolysosome
[] 
re1255
21772323 

Alpha-synuclein / Lewy Bodies
autolysosome
cytosol
Autolysosome
[] 
 s2132
[] 
re1258
10567343 

Alpha-synuclein / Lewy Bodies
cytosol
SNCA
[P37840
UPS
[] 
s2133
[] 
re1259
11463332 

microglia
Microglia
NOS2
[P35228
 NO
[CHEBI:16480
re1260
11463332 

Astrocyte
astrocyte
NOS2
[P35228
 NO
[CHEBI:16480
re1261
20303880 

microglia
Microglia
NO
[CHEBI:16480
 NO
[CHEBI:16480
re1262
20303880 

Astrocyte
astrocyte
NO
[CHEBI:16480
 NO
[CHEBI:16480
re1269
21127069 

21555069 

Microtubules
MAPT/Tau Phosphorylation
cytosol
MAPT
[P10636
MPTP
[],
activated LRRK2
[Q5S007],
MAPK8
[P45983],
MAPK11
[Q15759],
MAPK12
[P53778],
MAPK13
[O15264],
MAPK14
[Q16539],
GSK3B
[P49841
MAPT
[P10636
re1270
22014436 

17447891 

Microtubules
MAPT/Tau Phosphorylation
cytosol
MSN
[P26038
activated LRRK2
[Q5S007
MSN
[P26038
re1271
17447891 

Microtubules
MAPT/Tau Phosphorylation
cytosol
EZR
[P15311
activated LRRK2
[Q5S007
EZR
[P15311
re1272
17447891 

Microtubules
MAPT/Tau Phosphorylation
cytosol
RDX
[P35241
activated LRRK2
[Q5S007
RDX
[P35241
re1273
22014436 

19545277 

Microtubules
MAPT/Tau Phosphorylation
cytosol
Beta tubulin
[] 
activated LRRK2
[Q5S007
Beta tubulin
[] 
re1274
22014436 

20949042 

Microtubules
MAPT/Tau Phosphorylation
cytosol
TAOK3
[Q9H2K8
activated LRRK2
[Q5S007
TAOK3
[Q9H2K8
re1275
22014436 

20949042 

Microtubules
MAPT/Tau Phosphorylation
cytosol
STK3
[Q13188
activated LRRK2
[Q5S007
STK3
[Q13188
re1276
22014436 

20949042 

Microtubules
MAPT/Tau Phosphorylation
cytosol
STK24
[Q9Y6E0
activated LRRK2
[Q5S007
STK24
[Q9Y6E0
re1277
22014436 

20949042 

Microtubules
MAPT/Tau Phosphorylation
cytosol
STK25
[O00506
activated LRRK2
[Q5S007
STK25
[O00506
re1278
22014436 

20949042 

Microtubules
MAPT/Tau Phosphorylation
cytosol
LRRK2
[Q5S007
PRKCZ
[Q05513
LRRK2
[Q5S007
re1279
18701920 

21159966 

Microtubules
MAPT/Tau Phosphorylation
cytosol
EIF4EBP1
[Q13541
activated LRRK2
[Q5S007
EIF4EBP1
[Q13541
re1280
20624856 

Microtubules
MAPT/Tau Phosphorylation
cytosol
FOXO1
[Q12778
activated LRRK2
[Q5S007
FOXO1
[Q12778
re1284
21173802 

21151134 

Dopamine Secretion / Recycling
cytosol
misfolded
[P60880
 misfolded
[P60880
re1285
21173802 

21151134 

Dopamine Secretion / Recycling
cytosol
misfolded
[P60880
UPS
[] 
s2242
[] 
re1287
16247008 

22424229 

22014436 

11588178 

11701929 

15358157 

Alpha-synuclein / Lewy Bodies
cytosol
protofibril
[P37840
dopamine
[CHEBI:18243],
L-dopa
[CHEBI:15765],
geldanamycin
[] 
fibril
[P37840
re1288
19524782 

Alpha-synuclein / Lewy Bodies
Lewy body
cytosol
fibril
[P37840
 fibril
[P37840
re1292
12702778 

14704277 

Inflammation Signalling / Apoptosis
Apoptosis
nucleus
cytosol
PTGS2
[] 
NF-kB
[P19838, Q04206],
MAPK9
[P45984],
MAPK10
[P53779
PTGS2
[] 
re1297
18307977 

11729303 

Fatty Acid / Ketone Body Metabolism
cytosol
prostaglandin H2
[CHEBI:15554
PTGES2
[Q9H7Z7],
PTGES
[O14684],
PTGES3
[Q15185
prostaglandin E2
[CHEBI:15551
re1298
11729303 

Fatty Acid / Ketone Body Metabolism
cytosol
prostaglandin H2
[CHEBI:15554
PTGDS
[P41222],
UPS
[] 
prostaglandin D2
[CHEBI:15555
re1299
11729303 

Fatty Acid / Ketone Body Metabolism
cytosol
prostaglandin H2
[CHEBI:15554
AKR1C3
[P42330
prostaglandin F2 alpha
[CHEBI:15553
re1301
22014436 

20489724 

Dopamine Secretion / Recycling
cytosol
fusing synaptic vesicle
SNCA
[P37840
 arachidonic acid
[CHEBI:15843
re1302
20489724 

Dopamine Secretion / Recycling
cytosol
SNCA
[P37840
 arachidonic acid
[CHEBI:15843
re1303
22424229 

Alpha-synuclein / Lewy Bodies
cytosol
SNCA
[P37840
 fibril
[P37840
re1304
22424229 

Alpha-synuclein / Lewy Bodies
cytosol
SNCA
[P37840
 fibril
[P37840
re1305
12124613 

22014436 

11425308 

12367530 

Alpha-synuclein spreading
cytosol
protofibril
[P37840
 protofibril
[P37840
re1306
17715357 

20484626 

Alpha-synuclein spreading
cytosol
Ca2+
[CHEBI:29108
protofibril
[P37840],
ionomycin
[],
BAPTA
[] 
Ca2+
[CHEBI:29108
re1307
15791003 

20303880 

microglia
Microglia
extracellular alpha synuclein
[P37840
phagocytosis
[] 
alpha synuclein
[P37840
re1308
20303880 

microglia
Microglia
alpha synuclein
[P37840
ROS
[CHEBI:26523
oxidized alpha synuclein
[P37840
re1309
20303880 

15998743 

microglia
Microglia
alpha synuclein
[P37840
NO
[CHEBI:16480],
peroxynitrite
[CHEBI:25941
nitrated alpha synuclein
[P37840
re1310
20303880 

microglia
Microglia
oxidized alpha synuclein
[P37840
 microglia activation
[] 
re1311
20303880 

microglia
Microglia
nitrated alpha synuclein
[P37840
 microglia activation
[] 
re1312
20303880 

Astrocyte
astrocyte
ROS
[CHEBI:26523
 ROS
[CHEBI:26523
re1313
20303880 

microglia
Microglia
ROS
[CHEBI:26523
 ROS
[CHEBI:26523
re1314
12631585 

20303880 

microglia
Microglia
microglia activation
[] 
 NOS2
[P35228
re1315
20303880 

microglia
Microglia
microglia activation
[] 
 ROS
[CHEBI:26523
re1316
20303880 

microglia
Microglia
microglia activation
[] 
 PTGS2
[P35354
re1317
12631585 

20303880 

microglia
Microglia
microglia activation
[] 
 TNF
[P01375
re1318
21467220 

microglia
Microglia
Glucocorticoid:NR3C1
[P04150, CHEBI:24261
 microglia activation
[] 
re1319
21467220 

microglia
Microglia
glucocorticoid
[CHEBI:24261
 glucocorticoid
[CHEBI:24261
re1320
21467220 

microglia
Microglia
glucocorticoid
[CHEBI:24261],
NR3C1
[P04150
 Glucocorticoid:NR3C1
[P04150, CHEBI:24261
re1324
19840553 

microglia
Microglia
cell surface PRR signaling pathway
[] 
 TLR2
[O60603
re1325
19840553 

microglia
Microglia
cell surface PRR signaling pathway
[] 
 TLR3
[O15455
re1326
19840553 

microglia
Microglia
cell surface PRR signaling pathway
[] 
 TLR4
[O00206
re1327
19840553 

microglia
Microglia
TLR2
[O60603
 NIK/NF-kappaB cascade
[] 
re1328
19840553 

microglia
Microglia
TLR3
[O15455
 NIK/NF-kappaB cascade
[] 
re1329
19840553 

microglia
Microglia
TLR4
[O00206
 NIK/NF-kappaB cascade
[] 
re1330
16495942 

mitochondrial outer membrane
PINK1 / Parkin Pathway
mitochondrial inner membrane
cytosol
Mitochondrial permeability transition pore (close)
[P21796, P12235, P30405
ROS
[CHEBI:26523],
mitochondrial depolarization
[],
ATP
[CHEBI:15422
Mitochondrial permeability transition pore (open)
[P21796, P12235, P30405
re1331
16495942 

mitochondrial outer membrane
mitochondrial inner membrane
cytosol
Ca2+
[CHEBI:29108
Mitochondrial permeability transition pore (open)
[P21796, P12235, P30405
Ca2+
[CHEBI:29108
re1332
22026965 

Dopamine Secretion / Recycling
dopamine-loaded synaptic vesicle
acidified vesicle
cytosol
acidified vesicle
[] 
LRRK2
[Q5S007
dopamine-loaded synaptic vesicle
[] 
re1333
21151134 

Dopamine Secretion / Recycling
docked dynaptic vesicle
cytosol
fusing synaptic vesicle
docked synaptic vesicle
[] 
 fusing synaptic vesicle
[] 
re1334
21151134 

Dopamine Secretion / Recycling
docked dynaptic vesicle
cytosol
fusing synaptic vesicle
fusing synaptic vesicle
[] 
 docked synaptic vesicle
[] 
re1335
22026965 

21151134 

23060190 

11580898 

20798282 

Dopamine Secretion / Recycling
dopamine-loaded synaptic vesicle
docked dynaptic vesicle
cytosol
Syntaxin:Munc18
[P61764, Q16623],
SNAP25
[P60880],
VAMP2
[P63027
CSP:Hsc70:SGT
[P11142, O43765, Q9H3Z4],
SNCA
[P37840],
Calcium channel:RIMBP:RIM:MUNC13:RAB
[],
CPLX1
[O14810
trans-SNARE complex
[P61764, P63027, Q16623, P60880
re1336
21173802 

21151134 

Dopamine Secretion / Recycling
cytosol
SNAP25
[P60880
 misfolded
[P60880
re1337
22026965 

15629643 

Dopamine Secretion / Recycling
acidified vesicle
cytosol
H+
[CHEBI:15378],
ATP
[CHEBI:15422
V-ATPase
[] 
H+
[CHEBI:15378],
ADP
[CHEBI:16761
re1338
22026965 

9362506 

21040848 

Dopamine Secretion / Recycling
cytosol
cis-SNARE complex
[P61764, P63027, Q16623, P60880
NSF:NAPA
[P46459, O96009],
NSF:NAPB
[P46459, Q9H115
Syntaxin:Munc18
[P61764, Q16623],
SNAP25
[P60880],
VAMP2
[P63027
re1339
22026965 

Dopamine Secretion / Recycling
cytosol
UNC13B
[O14795
Ca2+
[CHEBI:29108
UNC13B
[O14795
re1340
22026965 

16732694 

Dopamine Secretion / Recycling
cytosol
UNC13B
[O14795],
RIMS1
[Q86UR5
 RIMS:Munc13
[Q86UR5, O14795
re1341
22026965 

Dopamine Secretion / Recycling
cytosol
Ca2+
[CHEBI:29108
Ca channel:RIMBP
[] 
Ca2+
[CHEBI:29108
re1342
22026965 

Dopamine Secretion / Recycling
dopamine-loaded synaptic vesicle
docked dynaptic vesicle
cytosol
Ca channel:RIMBP
[],
RIMS:Munc13
[Q86UR5, O14795],
RAB3A
[P20336
 Calcium channel:RIMBP:RIM:MUNC13:RAB
[] 
re1343
22026965 

Dopamine Secretion / Recycling
cytosol
fusing synaptic vesicle
trans-SNARE complex
[P61764, P63027, Q16623, P60880
 cis-SNARE complex
[P61764, P63027, Q16623, P60880
re1345
22026965 

Dopamine Secretion / Recycling
acidified vesicle
cytosol
fusing synaptic vesicle
fusing synaptic vesicle
[] 
LRRK2
[Q5S007
acidified vesicle
[] 
re1347
22026965 

Dopamine Secretion / Recycling
acidified vesicle
early endosome
cytosol
acidified vesicle
[] 
 early endosome
[] 
re1348
22026965 

Dopamine Secretion / Recycling
dopamine-loaded synaptic vesicle
early endosome
cytosol
early endosome
[] 
 dopamine-loaded synaptic vesicle
[] 
re1350
22448035 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
PINK1:PARK2
[O60260, Q9BXM7
 mitophagy
[] 
re1351
22078885 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
RHOT1
[Q8IXI2
PINK1:PARK2
[O60260, Q9BXM7
RHOT1
[Q8IXI2
re1352
22078885 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
RHOT2
[Q8IXI1
PINK1:PARK2
[O60260, Q9BXM7
RHOT2
[Q8IXI1
re1353
22078885 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
RHOT1
[Q8IXI2],
TRAK1
[Q9UPV9
 Miro-1:Milton:Kinesin-1 heavy chain
[Q9UPV9, P33176, Q8IXI2],
KIF5B
[P33176
re1354
22078885 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
RHOT2
[Q8IXI1],
TRAK1
[Q9UPV9
 Miro-2:Milton:Kinesin-1 heavy chain
[Q9UPV9, Q8IXI1, P33176],
KIF5B
[P33176
re1355
22078885 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
Miro-1:Milton:Kinesin-1 heavy chain
[Q9UPV9, P33176, Q8IXI2
 mitochondrial motility
[] 
re1356
22078885 

mitochondrial outer membrane
cytosol
Miro-2:Milton:Kinesin-1 heavy chain
[Q9UPV9, Q8IXI1, P33176
 mitochondrial motility
[] 
re1357
22078885 

PINK1 / Parkin Pathway
cytosol
RHOT1
[Q8IXI2
UPS
[] 
s2309
[] 
re1358
22078885 

PINK1 / Parkin Pathway
cytosol
RHOT2
[Q8IXI1
UPS
[] 
s2309
[] 
re1359
21173115 

21615408 

20871098 

PINK1 / Parkin Pathway
cytosol
MFN1
[Q8IWA4
UPS
[] 
s2310
[] 
re1360
21173115 

20871098 

PINK1 / Parkin Pathway
cytosol
MFN2
[O95140
UPS
[] 
s2310
[] 
re1361
17579517 

mitochondrial outer membrane
Apoptosis
cytosol
ROS
[CHEBI:26523
 PINK1
[Q9BXM7
re1362
17579517 

mitochondrial outer membrane
Apoptosis
cytosol
TRAP1
[Q12931
PINK1
[Q9BXM7
TRAP1
[Q12931
re1363
20053987 

18245082 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
SNCA
[P37840
 ROS
[CHEBI:26523
re1364
18245082 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
SNCA
[P37840
TOM complex
[Q96B49, O94826, O96008, Q9P0U1, Q15388, Q8N4H5, Q9NS69
SNCA
[P37840
re1365
21454557 

22448035 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
TOM complex
[Q96B49, O94826, O96008, Q9P0U1, Q15388, Q8N4H5, Q9NS69
PINK1:PARK2
[O60260, Q9BXM7
TOM complex
[Q96B49, O94826, O96008, Q9P0U1, Q15388, Q8N4H5, Q9NS69
re1367
17906618 

mitochondrial outer membrane
Apoptosis
cytosol
HTRA2
[O43464
MAPK12
[P53778],
PINK1
[Q9BXM7],
MAPK14
[Q16539
HTRA2
[O43464
re1368
20053987 

18245082 

20887775 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
SNCA
[P37840
 ROS
[CHEBI:26523
re1371
21489994 

mitochondrial outer membrane
PINK1 / Parkin Pathway
mitochondrial inner membrane
cytosol
SNCA
[P37840
 mitochondrial fission
[] 
re1372
21252228 

20887775 

mitochondrial outer membrane
PINK1 / Parkin Pathway
mitochondrial inner membrane
cytosol
SNCA
[P37840
 mitophagy
[] 
re1374
21489994 

mitochondrial outer membrane
PINK1 / Parkin Pathway
mitochondrial inner membrane
cytosol
SNCA
[P37840
 mitochondrial fission
[] 
re1375
21489994 

mitochondrial outer membrane
PINK1 / Parkin Pathway
mitochondrial inner membrane
cytosol
SNCA
[P37840
 mitochondrial fission
[] 
re1376
21489994 

mitochondrial outer membrane
PINK1 / Parkin Pathway
mitochondrial inner membrane
cytosol
protofibril
[P37840
 mitochondrial fission
[] 
re1379
20484626 

multivesicular body
Alpha-synuclein spreading
exosome
cytosol
multivesicular body
[] 
Ca2+
[CHEBI:29108],
thapsigargin
[],
methylamine
[],
ionomycin
[],
BAPTA
[] 
exosome
[] 
re1380
20484626 

Alpha-synuclein spreading
exosome
exosome
[] 
 SNCA
[P37840],
protofibril
[P37840],
GAPDH
[P04406],
PDCD6IP
[Q8WUM4],
ANXA2
[P07355],
flotillin
[Q14254, O75955],
HSP70
[Q9Y4L1
re1381
21645191 

18309064 

multivesicular body
late endosome
Alpha-synuclein spreading
cytosol
late endosome
[] 
 multivesicular body
[] 
re1382
22193161 

21878991 

Dopamine Secretion / Recycling
late endosome
early endosome
cytosol
early endosome
[] 
RAB5A
[P20339
late endosome
[] 
re1383
12835121 

Dopamine Metabolism
cytosol
dopamine
[CHEBI:18243
TYR
[P14679
dopaminoquinone
[CHEBI:74684
re1385
12835121 

Dopamine Metabolism
cytosol
dopaminoquinone
[CHEBI:74684
SOD1
[P00441
dopamine
[CHEBI:18243
re1386
12835121 

Dopamine Metabolism
cytosol
L-dopa
[CHEBI:15765
TYR
[P14679
L-dopaquinone
[CHEBI:16852
re1388
12835121 

Dopamine Metabolism
cytosol
dopaminoquinone
[CHEBI:74684],
generic protein
[] 
 Protein-dopamine adducts
[] 
re1389
12835121 

Dopamine Metabolism
cytosol
generic protein
[],
L-dopaquinone
[CHEBI:16852
 Protein-dopa adducts
[] 
re1390
12835121 

Dopamine Metabolism
cytosol
dopaminoquinone
[CHEBI:74684],
SNCA
[P37840
 SNCA
[P37840
re1391
12835121 

Dopamine Metabolism
cytosol
SNCA
[P37840],
L-dopaquinone
[CHEBI:16852
 SNCA
[P37840
re1392
12835121 

Dopamine Metabolism
cytosol
dopaminoquinone
[CHEBI:74684
 leukoaminochrome
[CID 147311
re1393
12835121 

Dopamine Metabolism
cytosol
L-dopaquinone
[CHEBI:16852
 leucodopachrome
[CHEBI:60872
re1394
12835121 

Dopamine Metabolism
cytosol
leucodopachrome
[CHEBI:60872
 L-dopachrome
[CHEBI:15772
re1395
12835121 

Dopamine Metabolism
cytosol
L-dopachrome
[CHEBI:15772
 5,6-dihydroxyindole
[CHEBI:27404
re1396
12835121 

Dopamine Metabolism
cytosol
leukoaminochrome
[CID 147311
 indole-5,6-quinone
[CHEBI:27406
re1397
12835121 

Dopamine Metabolism
cytosol
5,6-dihydroxyindole
[CHEBI:27404
 indole-5,6-quinone
[CHEBI:27406
re1398
12835121 

Dopamine Metabolism
cytosol
L-dopachrome
[CHEBI:15772
 5,6-dihydroxyindole-2-carboxylic acid
[CHEBI:2003
re1400
12835121 

Dopamine Metabolism
cytosol
5,6-dihydroxyindole
[CHEBI:27404
 indole-5,6-quinone
[CHEBI:27406
re1402
12835121 

Dopamine Metabolism
cytosol
5,6-dihydroxyindole-2-carboxylic acid
[CHEBI:2003],
indole-5,6-quinone
[CHEBI:27406
polymerization
[] 
neuromelanin
[] 
re1403
12835121 

Dopamine Metabolism
cytosol
indole-5,6-quinone
[CHEBI:27406
NQO1
[P15559
leukoaminochrome
[CID 147311
re1405
20303880 

microglia
Microglia
alpha synuclein
[P37840
 microglia activation
[] 
re1407
14607932 

microglia
Microglia
cytosol
CX3CL1
[P78423
 CX3CR1
[P49238
re1409
16339510 

microglia
Microglia
SIRPA
[P78324
 microglia activation
[] 
re1410
19627440 

16732273 

19840553 

microglia
Microglia
CX3CR1
[P49238
 microglia activation
[] 
re1411
20234358 

microglia
Microglia
CD200R1
[Q8TD46
 microglia activation
[] 
re1413
16467521 

microglia
Microglia
NXPH1:PLXNA1
[O14786, Q9UIW2
 apoptosis
[] 
re1414
16467521 

microglia
Microglia
apoptosis
[] 
 microglia activation
[] 
re1415
16467521 

microglia
Microglia
microglia activation
[] 
 PLXNA1
[Q9UIW2
re1416
16467521 

microglia
Microglia
microglia activation
[] 
 NRP1
[O14786
re1418
16467521 

microglia
Microglia
SEMA3A
[Q14563
 NXPH1:PLXNA1
[O14786, Q9UIW2
re1419
16467521 

cytosolSEMA3A
[Q14563
 SEMA3A
[Q14563
re1420
16467521 

microglia
Microglia
NRP1
[O14786],
PLXNA1
[Q9UIW2
 NXPH1:PLXNA1
[O14786, Q9UIW2
re1421
22503440 

21248133 

20303880 

microglia
Microglia
microglia activation
[] 
 NADPH oxidase complex
[P04839, P14598, Q9HBY0
re1422
16467521 

microglia
Microglia
IFNG
[P01579
 IFNGR1:IFNGR2:JAK1:JAK2
[P23458, P15260, O60674, P38484
re1423
16467521 

microglia
Microglia
IFNGR1:IFNGR2:JAK1:JAK2
[P23458, P15260, O60674, P38484
 microglia activation
[] 
re1424
15095367 

microglia
Microglia
cytosol
CD22
[P20273
 PTPRC
[P08575
re1425
15095367 

microglia
Microglia
PTPRC
[P08575
 microglia activation
[] 
re1426
20303880 

microglia
Microglia
LPS
[CHEBI:16412
 TLR4
[O00206
re1427
20303880 

microglia
Microglia
TLR2
[O60603
 MAPK cascade
[] 
re1428
20303880 

microglia
Microglia
TLR3
[O15455
 MAPK cascade
[] 
re1429
20303880 

microglia
Microglia
TLR4
[O00206
 MAPK cascade
[] 
re1430
22025055 

microglia
Microglia
NIK/NF-kappaB cascade
[] 
 microglia activation
[] 
re1432
12631585 

microglia
Microglia
neuromelanin
[] 
 NIK/NF-kappaB cascade
[] 
re1433
12631585 

microglia
Microglia
neuromelanin
[] 
 MAPK cascade
[] 
re1434
12631585 

cytosolneuromelanin
[] 
neuron death
[] 
neuromelanin
[] 
re1436
11304122 

Fatty Acid / Ketone Body Metabolism
cytosol
peroxide
[CHEBI:44785
 ROS
[CHEBI:26523
re1437
12297501 

Calcium Signalling
cytosol
nucleus
ATXN3
[P54252
 CREB:CBP
[Q92793, P16220
re1438
19843543 

Calcium Signalling
cytosol
nucleus
ATXN3
[P54252
ROS
[CHEBI:26523
ATXN3
[P54252
re1439
22193161 

late endosome
cytosol
RAB7A
[P51149
TBC1D5
[Q92609
RAB7A
[P51149
re1441
22193161 

late endosome
cytosol
VPS29:VPS26:VPS29
[Q96QK1, Q4G0F5, O75436, Q9UBQ0],
RAB7A
[P51149
 VPS29:VPS26:VPS29:RAB7A
[P51149, Q96QK1, Q4G0F5, O75436, Q9UBQ0
re1442
22193161 

late endosome
cytosol
VPS29:VPS26:VPS29:RAB7A
[P51149, Q96QK1, Q4G0F5, O75436, Q9UBQ0],
SNX1:SNX2:SNX5:SNX6:SNX32
[O60749, Q9Y5X3, Q9UNH7, Q13596, Q86XE0
 VPS29:VPS26:VPS29:RAB7A:SNX1:SNX2:SNX5:SNX6:SNX32
[P51149, Q96QK1, O60749, Q4G0F5, Q9Y5X3, Q9UNH7, O75436, Q13596, Q9UBQ0, Q86XE0
re1443
22193161 

21878991 

late endosome
trans-Golgi network
cytosol
late endosome
[] 
retrograde transport, endosome to Golgi
[] 
trans-Golgi network
[] 
re1444
22193161 

late endosome
cytosol
VPS29:VPS26:VPS29:RAB7A:SNX1:SNX2:SNX5:SNX6:SNX32
[P51149, Q96QK1, O60749, Q4G0F5, Q9Y5X3, Q9UNH7, O75436, Q13596, Q9UBQ0, Q86XE0
 retrograde transport, endosome to Golgi
[] 
re1445
22193161 

Dopamine Secretion / Recycling
early endosome
cytosol
RAB7A
[P51149
TBC1D5
[Q92609
RAB7A
[P51149
re1446
22193161 

Dopamine Secretion / Recycling
early endosome
cytosol
RAB7A
[P51149
 RAB7A
[P51149
re1447
22193161 

Dopamine Secretion / Recycling
early endosome
cytosol
VPS29:VPS26:VPS35
[Q96QK1, Q4G0F5, O75436, Q9UBQ0],
RAB7A
[P51149
 VPS29:VPS26:VPS35:RAB7A
[P51149, Q96QK1, Q4G0F5, O75436, Q9UBQ0
re1448
22193161 

Dopamine Secretion / Recycling
early endosome
cytosol
VPS29:VPS26:VPS35:RAB7A
[P51149, Q96QK1, Q4G0F5, O75436, Q9UBQ0],
SNX1:SNX2:SNX5:SNX6:SNX32
[O60749, Q9Y5X3, Q9UNH7, Q13596, Q86XE0
 VPS29:VPS26:VPS29:RAB7A:SNX1:SNX2:SNX5:SNX6:SNX32
[P51149, Q96QK1, O60749, Q4G0F5, Q9Y5X3, Q9UNH7, O75436, Q13596, Q9UBQ0, Q86XE0
re1449
22193161 

Dopamine Secretion / Recycling
early endosome
cytosol
VPS29:VPS26:VPS29:RAB7A:SNX1:SNX2:SNX5:SNX6:SNX32
[P51149, Q96QK1, O60749, Q4G0F5, Q9Y5X3, Q9UNH7, O75436, Q13596, Q9UBQ0, Q86XE0
 retrograde transport, endosome to Golgi
[] 
re1450
22193161 

21878991 

Dopamine Secretion / Recycling
early endosome
trans-Golgi network
cytosol
early endosome
[] 
retrograde transport, endosome to Golgi
[] 
trans-Golgi network
[] 
re1451
22193161 

Dopamine Secretion / Recycling
early endosome
cytosol
VPS29:VPS26:VPS35
[Q96QK1, Q4G0F5, O75436, Q9UBQ0],
SNX3:SNX12
[O60493, Q9UMY4
 VPS29:VPS26A:VPS26B:VPS35:SNX3:SNX12
[Q96QK1, Q4G0F5, O60493, O75436, Q9UMY4, Q9UBQ0
re1452
20619655 

mitochondrial outer membrane
peroxisome
cytosol
VPS26:VPS35:MUL1
[Q96QK1, Q4G0F5, O75436, Q969V5
 VPS26:VPS35:MUL1
[Q96QK1, Q4G0F5, O75436, Q969V5
re1453
22193161 

10679007 

21878991 

Alpha-synuclein / Lewy Bodies
endolysosome
lysosome
late endosome
cytosol
late endosome
[],
lysosome
[] 
RAB7A
[P51149
endolysosome
[] 
re1454
22193161 

Dopamine Secretion / Recycling
early endosome
cytosol
VPS29:VPS26A:VPS26B:VPS35:SNX3:SNX12
[Q96QK1, Q4G0F5, O60493, O75436, Q9UMY4, Q9UBQ0
 retrograde transport, endosome to Golgi
[] 
re1471
17027339 

PINK1 / Parkin Pathway
cytosol
Alpha tubulin
[] 
UPS
[] 
s2404
[] 
re1472
17027339 

PINK1 / Parkin Pathway
cytosol
GPR37
[O15354
UPS
[] 
s2404
[] 
re1473
21151032 

PINK1 / Parkin Pathway
cytosol
SNCAIP
[Q9Y6H5
UPS
[] 
s2404
[] 
re1474
17027339 

PINK1 / Parkin Pathway
cytosol
cyclin E (ubiquitinated)
[P24864, O96020
UPS
[] 
s2404
[] 
re1475
17027339 

PINK1 / Parkin Pathway
cytosol
SYT11
[Q9BT88
UPS
[] 
s2404
[] 
re1476
17027339 

PINK1 / Parkin Pathway
cytosol
SEPT5
[Q99719
UPS
[] 
s2404
[] 
re1477
17027339 

PINK1 / Parkin Pathway
cytosol
FUBP1
[Q96AE4
UPS
[] 
s2404
[] 
re1478
17027339 

PINK1 / Parkin Pathway
cytosol
AIMP2
[Q13155
UPS
[] 
s2404
[] 
re1479
17027339 

PINK1 / Parkin Pathway
cytosol
RANBP2
[P49792
UPS
[] 
s2404
[] 
re1480
17027339 

PINK1 / Parkin Pathway
cytosol
SNCA
[P37840
UPS
[] 
s2404
[] 
re1481
17027339 

PINK1 / Parkin Pathway
cytosol
SLC6A3
[Q01959
UPS
[] 
s2404
[] 
re1482
17027339 

PINK1 / Parkin Pathway
cytosol
SIM2
[Q14190
UPS
[] 
s2404
[] 
re1485
19321346 

ROS-dependent NFE2L2 Signalling
cytosol
KEAP1
[Q14145],
PTMA
[P06454
 KEAP1:PTMA
[Q14145, P06454
re1486
19321346 

ROS-dependent NFE2L2 Signalling
cytosol
KEAP1
[Q14145],
PGAM5
[Q96HS1
 KEAP1:PGAM5
[Q96HS1, Q14145
re1553
21251164 

ROS-dependent NFE2L2 Signalling
cytosol
NFE2L2
[Q16236
KEAP1:CUL3
[Q13618, Q14145
NFE2L2
[Q16236
re1554
21251164 

20133743 

ROS-dependent NFE2L2 Signalling
cytosol
KEAP1:CUL3
[Q13618, Q14145
ROS
[CHEBI:26523
KEAP1:CUL3
[Q13618, Q14145
re1555
21251164 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
NFE2L2
[Q16236
 NFE2L2
[Q16236
re1556
18273910 

19321346 

14978030 

16928811 

ROS-dependent NFE2L2 Signalling
cytosol
NFE2L2
[Q16236
Protein kinase C, alpha/beta/gamma types
[],
CSNK2A2
[P19784],
MAPK1
[P28482],
MAPK8
[P45983],
EIF2AK3
[Q9NZJ5
NFE2L2
[Q16236
re1557
11309365 

12495618 

18931696 

11739566 

14711827 

Ubiquitin Proteasome System
cytosol
proteasome:substrate complex
[],
ATP
[CHEBI:15422
protein unfolding
[],
proteasome:substrate complex
[],
SNCA
[P37840],
SNCA
[P37840],
protofibril
[P37840],
protein deubiquitination
[] 
a24_degraded
[],
phosphate ion
[CHEBI:35780,CHEBI:18367],
ubiquitin
[P0CG48, P0CG47],
ADP
[CHEBI:16761
re1558
9576483 

21151032 

24563857 

23129554 

18931696 

19542204 

Ubiquitin Proteasome System
cytosol
ubiquitin activating enzyme (E1)
[P22314, A0AVT1],
UBL-acyl adenylate intermediate
[P0CG48, P0CG47, CHEBI:16027
GSH/GSSG ratio
[CHEBI:17858, CHEBI:16856
E1:ubiquitin complex
[P22314, A0AVT1, P0CG48, P0CG47, CHEBI:16027
re1559
21151032 

Ubiquitin Proteasome System
cytosol
E1:ubiquitin complex
[P22314, A0AVT1, P0CG48, P0CG47, CHEBI:16027
 E1
[P22314, A0AVT1],
AMP
[CHEBI:16027
re1560
24563857 

18931696 

Ubiquitin Proteasome System
cytosol
Ubiquitin-conjugating enzyme, E2
[],
E1:ubiquitin complex
[P22314, A0AVT1, P0CG48, P0CG47, CHEBI:16027
GSH/GSSG ratio
[CHEBI:17858, CHEBI:16856
E2:ubiquitin
[],
E1:ubiquitin complex
[P22314, A0AVT1, P0CG48, P0CG47, CHEBI:16027
re1561
18931696 

Ubiquitin Proteasome System
cytosol
generic protein
[],
E2:ubiquitin
[],
ubiquitin-protein ligase (E3)
[Q05086, O60260, Q15386
 E2:E3:substrate complex
[] 
re1562
18931696 

Ubiquitin Proteasome System
cytosol
generic protein
[],
ubiquitin
[P0CG48, P0CG47
ubiquitin-protein ligase (E3)
[Q05086, O60260, Q15386],
ubiquitin chain elongation factor (E4)
[] 
generic protein
[] 
re1564
18931696 

Ubiquitin Proteasome System
cytosol
generic protein
[] 
 endocytosis
[] 
re1565
12577062 

cytosoltetrodotoxin
[] 
 SHANK2
[Q9UPX8
re1566
12577062 

cytosoltetrodotoxin
[] 
 GRIN2B
[Q13224
re1568
12577062 

cytosoltetrodotoxin
[] 
 DLG4
[Q15334
re1569
12577062 

cytosoltetrodotoxin
[] 
 GRIN2A
[Q12879
re1570
12577062 

cytosoltetrodotoxin
[] 
 CAMK2A
[Q9UQM7
re1571
12577062 

cytosolproteasome inhibitor
[] 
 tetrodotoxin
[] 
re1573
21151032 

Ubiquitin Proteasome System
cytosol
E2:E3:substrate complex
[] 
 generic protein
[],
Ubiquitin-conjugating enzyme, E2
[],
ubiquitin-protein ligase (E3)
[Q05086, O60260, Q15386
re1574
18931696 

cytosolmisfolded
[Q99497
PARK2
[O60260
misfolded
[Q99497
re1575
18931696 

cytosolmisfolded
[Q99497
dynein
[] 
inclusion body
[] 
re1576
16972273 

18931696 

16352719 

cytosolPARK2
[O60260
LRRK2
[Q5S007],
PARK2
[O60260
PARK2
[O60260
re1577
18931696 

Ubiquitin Proteasome System
cytosol
ATXN3
[P54252
 type 3 spinocerebellar ataxia
[] 
re1580
12504083 

Ubiquitin Proteasome System
cytosol
VCP
[P55072],
UBE4B
[O95155
 VCP:UBE4B
[O95155, P55072
re1587
18931696 

Ubiquitin Proteasome System
cytosol
VCP
[P55072],
ATXN3
[P54252
 ataxin 3:VCP
[P54252, P55072
re1595
17565442 

18931696 

Ubiquitin Proteasome System
cytosol
misfolded
[] 
HSP70:chaperone
[P25686, Q9UNE7, Q9Y4L1, Q99933
generic protein
[] 
re1598
18931696 

cytosolSHANK2
[Q9UPX8
anchored proteasome
[],
pharmacological stimulation of synaptic activity
[] 
s1009
[] 
re1599
18931696 

cytosolDLG4
[Q15334
anchored proteasome
[],
pharmacological stimulation of synaptic activity
[] 
s1010
[] 
re1600
18931696 

cytosolGRIP1
[Q9Y3R0
anchored proteasome
[],
pharmacological stimulation of synaptic activity
[] 
s1007
[] 
re1601
18931696 

Dopamine Secretion / Recycling
cytosol
AKAP5
[P24588
anchored proteasome
[],
pharmacological stimulation of synaptic activity
[] 
s1008
[] 
re1602
16972273 

cytosolPARK2
[O60260],
HSP70
[Q9Y4L1
 PARK2:HSP70
[O60260, Q9Y4L1
re1606
16972273 

Ubiquitin Proteasome System
cytosol
dexamethasone
[] 
 ubiquitin
[P0CG48, P0CG47
re1607
16972273 

Ubiquitin Proteasome System
cytosol
dexamethasone
[] 
 Ubiquitin-conjugating enzyme, E2
[] 
re1608
16972273 

Ubiquitin Proteasome System
cytosol
dexamethasone
[] 
 ubiquitin-protein ligase (E3)
[Q05086, O60260, Q15386
re1609
16972273 

Ubiquitin Proteasome System
cytosol
dexamethasone
[] 
 26S hybrid proteasome
[Q15008, O00487, O00233, Q16186, P17980, P28070, P62191, O00231, O14818, P49720, P25788, P28074, Q99436, Q99460, P28066, P28072, P60900, P25787, P49721, P62195, P51665, O43242, P25786, P55036, P25789, P43686, O00232, P62333, P20618, P48556, P35998, Q13200
re1612
21151032 

Ubiquitin Proteasome System
cytosol
E1
[P22314, A0AVT1],
UBL-acyl adenylate intermediate
[P0CG48, P0CG47, CHEBI:16027
 E1:ubiquitin complex
[P22314, A0AVT1, P0CG48, P0CG47, CHEBI:16027
re1613
21151032 

Ubiquitin Proteasome System
cytosol
E1
[P22314, A0AVT1],
AMP
[CHEBI:16027
 E1:ubiquitin complex
[P22314, A0AVT1, P0CG48, P0CG47, CHEBI:16027
re1614
21151032 

Ubiquitin Proteasome System
cytosol
E1:ubiquitin complex
[P22314, A0AVT1, P0CG48, P0CG47, CHEBI:16027
 ubiquitin activating enzyme (E1)
[P22314, A0AVT1],
UBL-acyl adenylate intermediate
[P0CG48, P0CG47, CHEBI:16027
re1615
21151032 

Ubiquitin Proteasome System
cytosol
E1:ubiquitin complex
[P22314, A0AVT1, P0CG48, P0CG47, CHEBI:16027
 E1
[P22314, A0AVT1],
UBL-acyl adenylate intermediate
[P0CG48, P0CG47, CHEBI:16027
re1617
21151032 

Ubiquitin Proteasome System
cytosol
generic protein
[] 
protein deubiquitination
[] 
generic protein
[] 
re1618
17027339 

cytosolUBE2L3
[P68036],
PARK2
[O60260
 PARK2:UbcH7
[P68036, O60260
re1619
16030137 

Dopamine Metabolism
cytosol
Tyrosine 3-monooxygenase (Fe2+ cofactor)
[] 
cAMP/cGMP-dependent protein kinase
[] 
Tyrosine 3-monooxygenase (Fe2+ cofactor)
[] 
re1620
20961626 

10747881 

11588178 

Alpha-synuclein / Lewy Bodies
cytosol
SNCA
[P37840
ROS
[CHEBI:26523],
NO
[CHEBI:16480
misfolded
[P37840
re1621
11532332 

Dopamine Metabolism
cytosol
DOPAL
[CHEBI:27978
 ROS
[CHEBI:26523
re1622
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
NDUFB3
[O43676
 NADH-Q oxireductase (complex I)
[P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404
re1623
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
NDUFB5
[O43674
 NADH-Q oxireductase (complex I)
[P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404
re1624
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
NDUFB6
[O95139
 NADH-Q oxireductase (complex I)
[P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404
re1625
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
NDUFS3
[O75489
 NADH-Q oxireductase (complex I)
[P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404
re1626
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
NDUFS5
[O43920
 NADH-Q oxireductase (complex I)
[P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404
re1627
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
NDUFAB1
[O14561
 NADH-Q oxireductase (complex I)
[P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404
re1628
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
NDUFC1
[O43677
 NADH-Q oxireductase (complex I)
[P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404
re1629
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Glycolysis
cytosol
SDHA
[P31040
 Succinate dehydrogenase (complex II)
[CHEBI:16238, CHEBI:30408, O14521, P21912, Q99643, P31040
re1630
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Glycolysis
cytosol
SDHB
[P21912
 Succinate dehydrogenase (complex II)
[CHEBI:16238, CHEBI:30408, O14521, P21912, Q99643, P31040
re1631
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
UQCRB
[P14927
 ubiquinol, cytochrome-c reductase (complex III)
[CHEBI:26355, P14927, O14957, P07919, Q9Y276, P00156, O14949, CHEBI:30408, P22695, P31930, P47985, P0C7P4, Q9UDW1
re1632
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
UQCRC1
[P31930
 ubiquinol, cytochrome-c reductase (complex III)
[CHEBI:26355, P14927, O14957, P07919, Q9Y276, P00156, O14949, CHEBI:30408, P22695, P31930, P47985, P0C7P4, Q9UDW1
re1633
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
COX7B
[P24311
 cytochrome c oxidase (complex IV)
[Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954
re1634
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
COX7A1
[P24310
 cytochrome c oxidase (complex IV)
[Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954
re1635
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
COX7C
[P15954
 cytochrome c oxidase (complex IV)
[Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954
re1636
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
COX7A2L
[O14548
 cytochrome c oxidase (complex IV)
[Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954
re1637
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
COX7A2
[P14406
 cytochrome c oxidase (complex IV)
[Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954
re1638
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
COX6A1
[P12074
 cytochrome c oxidase (complex IV)
[Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954
re1639
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
COX5B
[P10606
 cytochrome c oxidase (complex IV)
[Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954
re1640
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
ATP5L
[O75964
 F0F1-ATP synthase (complex V)
[P36542, P48201, P25705, O75947, P30049, Q06055, P56385, O75964, P00846, P48047, Q9UII2, Q7Z4Y8, P05496, P06576, Q5VTU8, P56381, P03928, P18859, P56134, P24539
re1641
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
ATP5A1
[P25705
 F0F1-ATP synthase (complex V)
[P36542, P48201, P25705, O75947, P30049, Q06055, P56385, O75964, P00846, P48047, Q9UII2, Q7Z4Y8, P05496, P06576, Q5VTU8, P56381, P03928, P18859, P56134, P24539
re1642
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
ATP5C1
[P36542
 F0F1-ATP synthase (complex V)
[P36542, P48201, P25705, O75947, P30049, Q06055, P56385, O75964, P00846, P48047, Q9UII2, Q7Z4Y8, P05496, P06576, Q5VTU8, P56381, P03928, P18859, P56134, P24539
re1643
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
ATP5O
[P48047
 F0F1-ATP synthase (complex V)
[P36542, P48201, P25705, O75947, P30049, Q06055, P56385, O75964, P00846, P48047, Q9UII2, Q7Z4Y8, P05496, P06576, Q5VTU8, P56381, P03928, P18859, P56134, P24539
re1644
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
ATP5D
[P30049
 F0F1-ATP synthase (complex V)
[P36542, P48201, P25705, O75947, P30049, Q06055, P56385, O75964, P00846, P48047, Q9UII2, Q7Z4Y8, P05496, P06576, Q5VTU8, P56381, P03928, P18859, P56134, P24539
re1645
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
NDUFA8
[P51970
 NADH-Q oxireductase (complex I)
[P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404
re1650
16025099 

mitochondrial outer membrane
PINK1 / Parkin Pathway
mitochondrial inner membrane
cytosol
FIS1
[Q9Y3D6
 mitochondrial fission
[] 
re1651
12719433 

Alpha-synuclein / Lewy Bodies
cytosol
SNCA
[P37840
macroautophagy
[] 
s2462
[] 
re1652
15333840 

Alpha-synuclein / Lewy Bodies
cytosol
SNCA
[P37840
chaperone-mediated autophagy
[] 
s2464
[] 
re1654
15454081 

Calcium Signalling
cytosol
YWHAB
[P31946],
CRTC2
[Q53ET0
 TORC2:14-3-3
[P31946, Q53ET0
re1655
15454081 

Calcium Signalling
cytosol
CRTC2
[Q53ET0
SIK2
[Q9H0K1
CRTC2
[Q53ET0
re1656
14693422 

Calcium Signalling
cytosol
cAMP/cGMP-dependent protein kinase
[] 
 SIK2
[Q9H0K1
re1657
14693422 

Calcium Signalling
cytosol
cAMP
[CHEBI:17489
 cAMP/cGMP-dependent protein kinase
[] 
re1658
18094624 

20959619 

Calcium Signalling
cytosol
ROS
[CHEBI:26523
 autophagy
[] 
re1659
21127245 

Autophagy / Mitophagy
autolysosome
cytosol
autolysosome
[] 
 fatty acid
[CHEBI:35366
re1660
21127245 

Autophagy / Mitophagy
autolysosome
cytosol
autolysosome
[] 
 carbohydrate
[CHEBI:16646
re1661
21127245 

Autophagy / Mitophagy
autolysosome
cytosol
autolysosome
[] 
 nucleoside
[CHEBI:33838
re1662
16179260 

18570871 

Autophagy / Mitophagy
cytosol
BCL2:BECN1
[Q14457, P10415
MAPK8
[P45983
BCL2
[P10415],
BECN1
[Q14457
re1664
22078875 

Autophagy / Mitophagy
phagophore
cytosol
ULK1 complex
[O75143, Q8TDY2, Q9BSB4, O75385
 phagophore
[] 
re1665
16179260 

18570871 

Autophagy / Mitophagy
cytosol
BECN1
[Q14457],
BCL2
[P10415
 BCL2:BECN1
[Q14457, P10415
re1666
22078875 

Autophagy / Mitophagy
phagophore
cytosol
Class-III PI3K complex
[Q9C0C7, Q14457, Q99570, Q8NEB9, Q6ZNE5
 phagophore
[] 
re1667
20959619 

22078875 

Autophagy / Mitophagy
cytosol
ATG12
[O94817],
ATG7
[O95352
 ATG12:ATG7
[O94817, O95352
re1668
20959619 

22078875 

Autophagy / Mitophagy
cytosol
ATG12:ATG7
[O94817, O95352],
ATG10
[Q9H0Y0
 ATG12:ATG10
[Q9H0Y0, O94817],
ATG7
[O95352
re1669
20959619 

22078875 

Autophagy / Mitophagy
cytosol
ATG12:ATG10
[Q9H0Y0, O94817],
ATG5
[Q9H1Y0
 ATG12:ATG5
[O94817, Q9H1Y0],
ATG10
[Q9H0Y0
re1670
20959619 

22078875 

Autophagy / Mitophagy
cytosol
ATG12:ATG5
[O94817, Q9H1Y0],
ATG16L1
[Q676U5
 ATG12:ATG5:ATG16L1
[O94817, Q9H1Y0, Q676U5
re1671
20959619 

Autophagy / Mitophagy
cytosol
MAP1LC3A
[Q9H492
ATG4B
[Q9Y4P1
MAP1LC3A (LC3-I)
[Q9H492
re1672
22078875 

20959619 

Autophagy / Mitophagy
cytosol
LC3-I:ATG7
[O95352, Q9H492],
ATG3
[Q9NT62
 LC3-I:ATG3
[Q9NT62, Q9H492],
ATG7
[O95352
re1673
17986448 

22078875 

20959619 

Autophagy / Mitophagy
cytosol
LC3-I:ATG3
[Q9NT62, Q9H492],
phosphatidylethanolamine
[CHEBI:16038
ATG12:ATG5:ATG16L1
[O94817, Q9H1Y0, Q676U5
LC3-II
[CHEBI:16038, Q9H492],
ATG3
[Q9NT62
re1674
21251164 

ROS-dependent NFE2L2 Signalling
cytosol
NFE2L2
[Q16236
 s2485
[] 
re1676
21296869 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
FIS1
[Q9Y3D6
PINK1:PARK2
[O60260, Q9BXM7
s2486
[] 
re1677
21179059 

mitochondrial outer membrane
Calcium Signalling
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
CYCS
[P99999
 CYCS
[P99999
re1678
22025055 

microglia
Microglia
MAPK cascade
[] 
 microglia activation
[] 
re1679
16724054 

Inflammation Signalling / Apoptosis
cytosol
CHUK
[O15111],
IKBKB
[O14920],
IKBKG
[Q9Y6K9
 IKK complex
[O15111, Q9Y6K9, O14920
re1680
16724054 

Inflammation Signalling / Apoptosis
nucleus
cytosol
NF-kappa B
[P19838, Q04206
 NF-kB
[P19838, Q04206
re1681
17803915 

Dopamine Secretion / Recycling
cytosol
RIMS1
[Q86UR5
 s2490
[] 
re1682
17637737 

21878991 

Alpha-synuclein / Lewy Bodies
endolysosome
lysosome
cytosol
endolysosome
[] 
 lysosome
[] 
re1684
21855797 

Autophagy / Mitophagy
cytosol
ULK1:ATG13
[O75143, O75385
 s2495
[] 
re1685
21855797 

PINK1 / Parkin Pathway
Autophagy / Mitophagy
cytosol
ULK1:ATG13
[O75143, O75385],
HSP90:CDC37
[Q16543, P07900
 HSP90:CDC37:ULK1:ATG13
[O75143, Q16543, P07900, O75385
re1686
21855797 

PINK1 / Parkin Pathway
Autophagy / Mitophagy
cytosol
HSP90:CDC37:ULK1:ATG13
[O75143, Q16543, P07900, O75385
 HSP90:CDC37:ULK1:ATG13
[O75143, Q16543, P07900, O75385
re1687
21855797 

PINK1 / Parkin Pathway
cytosol
HSP90:CDC37:ULK1:ATG13
[O75143, Q16543, P07900, O75385
 ATG13
[O75143],
HSP90:CDC37:ULK1
[Q16543, P07900, O75385
re1688
21855797 

PINK1 / Parkin Pathway
cytosol
HSP90:CDC37:ULK1
[Q16543, P07900, O75385
 HSP90:CDC37
[Q16543, P07900],
ULK1
[O75385
re1689
21855797 

PINK1 / Parkin Pathway
Autophagy / Mitophagy
cytosol
ULK1
[O75385
 s2495
[] 
re1690
21855797 

PINK1 / Parkin Pathway
cytosol
ATG13
[O75143
 mitophagy
[] 
re1691
20098416 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
VDAC1
[P21796
 mitophagy
[] 
re1692
20098416 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
SQSTM1
[Q13501
PINK1:PARK2
[O60260, Q9BXM7
SQSTM1
[Q13501
re1693
20098416 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
SQSTM1
[Q13501
 mitophagy
[] 
re1694
21855797 

20098416 

autophagosome
PINK1 / Parkin Pathway
mitochondrion
Autophagy / Mitophagy
cytosol
mitochondrion
[],
LC3-II
[CHEBI:16038, Q9H492],
ATG13
[O75143
mitophagy
[] 
autophagosome
[] 
re1695
22889933 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
ROS
[CHEBI:26523
 mitochondrial depolarization
[] 
re1697
18039652 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial ROS Metabolism
cytosol
paraquat monocation radical
[],
O2
[CHEBI:15379
 paraquat dication
[],
superoxide
[CHEBI:18421
re1698
18039652 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
Mitochondrial ROS Metabolism
cytosol
paraquat dication
[] 
NADH-Q oxireductase (complex I)
[P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404],
superoxide
[CHEBI:18421
paraquat monocation radical
[] 
re1699
12631585 

microglia
Microglia
microglia activation
[] 
 IL6
[P05231
re1700
21292769 

PINK1 / Parkin Pathway
cytosol
DNM1L
[O00429
UPS
[] 
s2505
[] 
re1702
18931696 

Ubiquitin Proteasome System
cytosol
E2:ubiquitin
[],
E1:ubiquitin complex
[P22314, A0AVT1, P0CG48, P0CG47, CHEBI:16027
 Ubiquitin-conjugating enzyme, E2
[],
E1:ubiquitin complex
[P22314, A0AVT1, P0CG48, P0CG47, CHEBI:16027
re1703
21151032 

Ubiquitin Proteasome System
cytosol
ubiquitin
[P0CG48, P0CG47],
ATP
[CHEBI:15422
 UBL-acyl adenylate intermediate
[P0CG48, P0CG47, CHEBI:16027],
diphosphate ion
[CHEBI:29888,CHEBI:35782
re1704
18931696 

Ubiquitin Proteasome System
cytosol
generic protein
[],
26S hybrid proteasome
[Q15008, O00487, O00233, Q16186, P17980, P28070, P62191, O00231, O14818, P49720, P25788, P28074, Q99436, Q99460, P28066, P28072, P60900, P25787, P49721, P62195, P51665, O43242, P25786, P55036, P25789, P43686, O00232, P62333, P20618, P48556, P35998, Q13200
HSP70
[Q9Y4L1],
diffusion
[],
shutling factors
[P54727, P54725
proteasome:substrate complex
[] 
re1705
18931696 

Ubiquitin Proteasome System
cytosol
generic protein
[] 
protein deubiquitination
[] 
generic protein
[] 
re1712
23334208 

20303880 

cytosolTNFRSF1B
[P20333
TNF
[P01375
TNFRSF1B
[P20333
re1713
16724054 

Inflammation Signalling / Apoptosis
cytosol
TNFRSF1B
[P20333
 MAP3K7
[O43318
re1753
22965115 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
YAF2
[] 
NFE2L2
[Q16236
YAF2
[] 
re1754
22581777 

22965115 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
SLC25A25
[] 
NFE2L2
[Q16236
SLC25A25
[] 
re1755
22581777 

22965115 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
FTH1
[] 
NFE2L2
[Q16236
FTH1
[] 
re1756
22581777 

22965115 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
SLC7A11
[] 
NFE2L2
[Q16236
SLC7A11
[] 
re1757
22965115 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
ABCC1
[] 
NFE2L2
[Q16236
ABCC1
[] 
re1758
22965115 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
G6PD
[] 
NFE2L2
[Q16236
G6PD
[] 
re1759
22965115 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
BLVRB
[] 
NFE2L2
[Q16236
BLVRB
[] 
re1760
22581777 

22965115 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
GCLM
[] 
NFE2L2
[Q16236
GCLM
[] 
re1761
22965115 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
AOX1
[] 
NFE2L2
[Q16236
AOX1
[] 
re1762
22965115 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
IDH1
[] 
NFE2L2
[Q16236
IDH1
[] 
re1763
22581777 

22965115 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
TXN
[] 
NFE2L2
[Q16236
TXN
[] 
re1764
22581777 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
TKT
[] 
NFE2L2
[Q16236
TKT
[] 
re1765
22581777 

22965115 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
NQO1
[] 
NFE2L2
[Q16236
NQO1
[] 
re1766
22581777 

22965115 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
CEBPA
[] 
NFE2L2
[Q16236
CEBPA
[] 
re1767
22965115 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
HES1
[] 
NFE2L2
[Q16236
HES1
[] 
re1768
22581777 

22965115 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
PRDX1
[] 
NFE2L2
[Q16236
PRDX1
[] 
re1769
22581777 

22965115 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
GCLC
[] 
NFE2L2
[Q16236
GCLC
[] 
re1770
22581777 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
ADO
[] 
NFE2L2
[Q16236
ADO
[] 
re1771
22581777 

22965115 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
ABCB6
[] 
NFE2L2
[Q16236
ABCB6
[] 
re1772
22965115 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
GSTA4
[] 
NFE2L2
[Q16236
GSTA4
[] 
re1773
22965115 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
AHR
[] 
NFE2L2
[Q16236
AHR
[] 
re1774
22965115 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
LPL
[] 
NFE2L2
[Q16236
LPL
[] 
re1775
22581777 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
SRXN1
[] 
NFE2L2
[Q16236
SRXN1
[] 
re1776
22965115 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
GSTM2
[] 
NFE2L2
[Q16236
GSTM2
[] 
re1777
22581777 

22965115 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
MYC
[] 
NFE2L2
[Q16236
MYC
[] 
re1778
22581777 

22965115 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
GSR
[] 
NFE2L2
[Q16236
GSR
[] 
re1779
22581777 

22965115 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
FECH
[] 
NFE2L2
[Q16236
FECH
[] 
re1780
22581777 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
TXNRD1
[] 
NFE2L2
[Q16236
TXNRD1
[] 
re1781
22581777 

22965115 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
FTL
[] 
NFE2L2
[Q16236
FTL
[] 
re1782
22581777 

22965115 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
HMOX1
[] 
NFE2L2
[Q16236
HMOX1
[] 
re1783
22581777 

22965115 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
MAFG
[] 
NFE2L2
[Q16236
MAFG
[] 
re1784
22581777 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
ABCC5
[] 
NFE2L2
[Q16236
ABCC5
[] 
re1785
22965115 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
SLC44A3
[] 
NFE2L2
[Q16236
SLC44A3
[] 
re1786
22965115 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
GSTM3
[] 
NFE2L2
[Q16236
GSTM3
[] 
re1787
22581777 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
RXRA
[] 
NFE2L2
[Q16236
RXRA
[] 
re1788
22965115 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
MGST2
[] 
NFE2L2
[Q16236
MGST2
[] 
re1789
22581777 

22965115 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
SLC48A1
[] 
NFE2L2
[Q16236
SLC48A1
[] 
re1790
22965115 

20460467 

23664668 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
EPHX1
[] 
NFE2L2
[Q16236
EPHX1
[] 
re1791
20452972 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
SQSTM1
[] 
NFE2L2
[Q16236
SQSTM1
[] 
re1792
24201109 

lysosome
Autophagy / Mitophagy
autolysosome
cytosol
autolysosome
[] 
 lysosome
[] 
re1812
20057503 

20969953 

21277210 

Autophagy / Mitophagy
cytosol
PINK1
[Q9BXM7
 BECN1
[Q14457
re1824
16839884 

mitochondrial outer membrane
PINK1 / Parkin Pathway
mitochondrial inner membrane
cytosol
PARL
[Q9H300
 OPA1
[O60313
re1832
22769591 

12522269 

14962978 

Microtubules
MAPT/Tau Phosphorylation
cytosol
HSP70
[Q9Y4L1
 MAPT
[P10636
re1845
22388932 

PINK1 / Parkin Pathway
cytosol
NEDD8
[Q15843
 PINK1
[Q9BXM7
re1848
21962518 

Autophagy / Mitophagy
cytosol
USP13
[Q92995
 BECN1
[Q14457
re1852
20798862 

17534146 

Autophagy / Mitophagy
cytosol
ELAVL1
[Q15717
 MCL1
[Q07820
re1853
21325336 

16803882 

14744933 

17481747 

Calcium Signalling
cytosol
nucleus
MAPK p38
[] 
 PPARGC1A
[Q9UBK2
re1866
22238344 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
MARK2
[Q7KZI7
 PINK1
[Q9BXM7
re1872
17050673 

Calcium Signalling
cytosol
nucleus
LRPPRC
[P42704
 PPARGC1A
[Q9UBK2
re1875
18772134 

Autophagy / Mitophagy
cytosol
MYD88
[Q99836
 BECN1
[Q14457
re1879
19671798 

16434970 

21130123 

18443228 

18835031 

18713840 

14980220 

Apoptosis
cytosol
NR4A1
[P22736
 BCL2
[P10415
re1891
19180116 

Autophagy / Mitophagy
cytosol
DAPK1
[P53355
 BECN1
[Q14457
re1898
17878917 

16504941 

cytosolPIN1
[Q13526
 BCL2L11
[O43521
re1905
17878917 

21852138 

16099987 

11432833 

17965833 

20376080 

cytosolPIN1
[Q13526
 JUN
[P05412
re1906
21487019 

Microtubules
cytosol
HSP90
[P07900
 FGFR3
[P22607
re1909
20395553 

Postsynaptic terminal
GABAergic Neuron
RANBP9
[Q96S59
 PRKCD
[Q05655
re1911
21810655 

cytosolPIN1
[Q13526
 NOS3
[P29474
re1917
20638385 

Autophagy / Mitophagy
cytosol
BECN1
[Q14457
 BIRC5
[O15392
re1924
22789442 

cytosolPIN1
[Q13526
 NR4A3
[Q92570
re1925
22842492 

12228731 

mitochondrial outer membrane
cytosol
VDAC1
[P21796
 NOS3
[P29474
re1941
22643835 

Inflammation Signalling / Apoptosis
cytosol
PINK1
[Q9BXM7
 TRAF2:TRAF6
[Q9Y4K3, Q12933
re1951
20403074 

cytosolRANBP9
[Q96S59
 NTRK2
[Q16620
re1952
19324885 

Calcium Signalling
cytosol
nucleus
PPARGC1A
[Q9UBK2
 FOXO3
[O43524
re1958
21982763 

cytosolPIN1
[Q13526
 CAST
[P20810
re1959
19884383 

Calcium Signalling
cytosol
nucleus
PPARGC1A
[Q9UBK2
 AR
[P10275
re1962
11274399 

Calcium Signalling
cytosol
nucleus
PPARGC1A
[Q9UBK2
 MEF2C
[Q06413
re1970
21660049 

cytosolPIN1
[Q13526
 MAPK8
[P45983
re1975
14722085 

cytosolRANBP9
[Q96S59
 ITGB1
[P05556
re1984
20371703 

Calcium Signalling
cytosol
nucleus
PPARGC1A
[Q9UBK2
 VDR
[P11473
re1987
22002310 

22789442 

cytosolPIN1
[Q13526
 NR4A1
[P22736
re1988
17009320 

cytosolPIN1
[Q13526
 CTNND2
[Q9UQB3
re1993
22643835 

Inflammation Signalling / Apoptosis
cytosol
PINK1
[Q9BXM7
 MAP3K7
[O43318
re1996
19325567 

20356743 

PINK1 / Parkin Pathway
ER
Fatty Acid / Ketone Body Metabolism
cytosol
ITPR1
[Q14643
 BECN1
[Q14457
re2000
11331615 

cytosolHTT
[P42858
 UPS
[] 
re2003
19240029 

15664989 

21855799 

20943656 

Ubiquitin Proteasome System
cytosol
STUB1
[Q9UNE7
 ATXN3
[P54252
re2007
22012620 

late endosome
cytosol
MIR367
[] 
 VPS29:VPS26:VPS29
[Q96QK1, Q4G0F5, O75436, Q9UBQ0
re2010
22012620 

Dopamine Secretion / Recycling
early endosome
cytosol
MIR367
[] 
 VPS29:VPS26:VPS35
[Q96QK1, Q4G0F5, O75436, Q9UBQ0
re2011
22012620 

Dopamine Secretion / Recycling
early endosome
cytosol
MIR367
[] 
 VPS29:VPS26:VPS35
[Q96QK1, Q4G0F5, O75436, Q9UBQ0
re2014
22012620 

mitochondrial outer membrane
cytosol
MIR367
[] 
 VPS26:VPS35:MUL1
[Q96QK1, Q4G0F5, O75436, Q969V5
re2016
21062745 

19270696 

22423967 

22423966 

20943950 

20562859 

19372752 

19270693 

Autophagy / Mitophagy
cytosol
KIAA0226
[Q92622
 BECN1
[Q14457
re2020
20074525 

Calcium Signalling
cytosol
nucleus
CLK2
[P49760
 PPARGC1A
[Q9UBK2
re2023
12397057 

16267049 

15337744 

12181319 

Calcium Signalling
cytosol
nucleus
ESRRA
[P11474
 PPARGC1A
[Q9UBK2
re2039
20103533 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
MARCH5
[Q9NX47
 MFN1
[Q8IWA4
re2047
18201976 

Ubiquitin Proteasome System
cytosol
UPS
[] 
 ATXN3
[P54252
re2049
19706601 

Calcium Signalling
cytosol
nucleus
RNF139
[Q8WU17
 SREBF1
[P36956
re2050
20584899 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
MIR155
[] 
 TRAK1
[Q9UPV9
re2058
16282323 

Microtubules
cytosol
YWHAB
[P31946
 BCL2L11
[O43521
re2127
10942430 

12417652 

15459747 

17352931 

15115766 

cytosolHTT
[P42858
 HSP70
[Q9Y4L1
re2148
16950154 

Microtubules
MAPT/Tau Phosphorylation
cytosol
NPEPPS
[P55786
 MAPT
[P10636
re2155
22748923 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
MAPK9
[P45984
 MFN2
[O95140
re2157
22152474 

Autophagy / Mitophagy
cytosol
ATG12
[O94817
 MCL1
[Q07820
re2168
19457116 

Dopamine Secretion / Recycling
dopamine-loaded synaptic vesicle
cytosol
HSPA8
[P11142
 SLC18A2
[Q05940
re2187
21127500 

Apoptosis
cytosol
GRAMD4
[Q6IC98
 BCL2
[P10415
re2218
17303406 

16054087 

16825193 

Calcium Signalling
cytosol
nucleus
GSK3 alpha/beta
[P49840, P49841
 SREBF1
[P36956
re2238
21936852 

Autophagy / Mitophagy
cytosol
NEDD4
[P46934
 BECN1
[Q14457
re2246
20230784 

19158487 

mitochondrial outer membrane
Apoptosis
cytosol
NEK1
[Q96PY6
 VDAC1
[P21796
re2256
22099302 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
AKAP1
[Q92667
 DNM1L
[O00429
re2261
21396745 

7589162 

Dopamine Secretion / Recycling
dopamine-loaded synaptic vesicle
cytosol
DHTBZ
[] 
 SLC18A2
[Q05940
re2267
22969086 

19625249 

Calcium Signalling
cytosol
nucleus
PIAS1
[O75925
 PPARGC1A
[Q9UBK2
re2270
16446153 

Apoptosis
cytosol
BCL2
[P10415
 Alpha tubulin
[] 
re2280
21852138 

16139797 

16554819 

cytosolPIN1
[Q13526
 APP
[P05067
re2281
19996102 

cytosolPIN1
[Q13526
 PPARG
[P37231
re2282
20940043 

9753644 

Microtubules
microtubule
cytosol
HSP90
[P07900
 Tubulin
[Q9UJT0
re2283
16973602 

17317785 

Microtubules
cytosol
HSP90
[P07900
 APP
[P05067
re2284
20395553 

Postsynaptic terminal
GABAergic Neuron
RANBP9
[Q96S59
 DRD1
[P21728
re2286
16823798 

16973602 

cytosolHSP70
[Q9Y4L1
 APP
[P05067
re2289
16446153 

Apoptosis
cytosol
BCL2
[P10415
 Beta tubulin
[] 
re2302
17851643 

cytosolHSP70
[Q9Y4L1
 AURKA
[O14965
re2305
22184106 

cytosolPIN1
[Q13526
 GSK3B
[P49841
re2309
17190793 

Dopamine Secretion / Recycling
docked dynaptic vesicle
cytosol
SYT12
[Q8IV01
 SYT1
[P21579
re2326
20940148 

22081612 

PINK1 / Parkin Pathway
cytosol
ATXN3
[P54252
 PARK2
[O60260
re2344
20307651 

ROS-dependent NFE2L2 Signalling
cytosol
PIN1
[Q13526
 NFE2L2
[Q16236
re2346
19712056 

14557250 

cytosolUPS
[] 
 HTT
[P42858
re2348
10942430 

15459747 

17251428 

cytosolHSP70
[Q9Y4L1
 HTT
[P42858
re2359
19182807 

Apoptosis
cytosol
PIN1
[Q13526
 BAX
[Q07812
re2368
22105352 

late endosome
cytosol
VPS29:VPS26:VPS29
[Q96QK1, Q4G0F5, O75436, Q9UBQ0
 BACE1
[P56817
re2371
22105352 

Dopamine Secretion / Recycling
early endosome
cytosol
VPS29:VPS26:VPS35
[Q96QK1, Q4G0F5, O75436, Q9UBQ0
 BACE1
[P56817
re2380
18680712 

Calcium Signalling
cytosol
nucleus
PPARGC1A
[Q9UBK2
 SMARCD1
[Q96GM5
re2393
17932487 

Microtubules
MAPT/Tau Phosphorylation
cytosol
MAPT
[P10636
 DCTN1
[Q14203
re2397
20133804 

Microtubules
MAPT/Tau Phosphorylation
cytosol
FKBP4
[Q02790
 MAPT
[P10636
re2405
15953362 

Microtubules
MAPT/Tau Phosphorylation
cytosol
SQSTM1
[Q13501
 MAPT
[P10636
re2421
15953362 

Microtubules
MAPT/Tau Phosphorylation
cytosol
TRAF6
[Q9Y4K3
 MAPT
[P10636
re2443
18198341 

Calcium Signalling
cytosol
nucleus
FBXW7
[Q969H0
 PPARGC1A
[Q9UBK2
re2446
17606912 

19168699 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
BAK1
[Q16611
 MFN2
[O95140
re2454
19019695 

18198341 

Calcium Signalling
cytosol
nucleus
GSK3B
[P49841
 PPARGC1A
[Q9UBK2
re2457
21245165 

Microtubules
cytosol
MIR29B1
[] 
 BCL2L11
[O43521
re2465
12888622 

Apoptosis
cytosol
caspase-6
[P55212
 MAPT
[P10636
re2468
22570483 

19242788 

21878650 

21569010 

Apoptosis
cytosol
MIR449A
[] 
 BCL2
[P10415
re2483
19411255 

21339790 

17341580 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
SENP5
[Q96HI0
 DNM1L
[O00429
re2701
18497563 

12039864 

15733859 

10567572 

17928127 

16953201 

15225643 

18955970 

18570871 

Apoptosis
cytosol
MAPK8
[P45983
 BCL2
[P10415
re2721
22388891 

21151042 

19150432 

Microtubules
cytosol
BTRC
[Q9Y297
 BCL2L11
[O43521
re2732
17105775 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
VAT1
[P54219
 MFN1
[Q8IWA4
re2734
21976705 

22301997 

22081109 

Autophagy / Mitophagy
cytosol
TAB2
[Q9NYJ8
 BECN1
[Q14457
re2738
20194433 

Calcium Signalling
cytosol
nucleus
PROX1
[Q92786
 PPARGC1A
[Q9UBK2
re2743
8674537 

7531159 

Microtubules
MAPT/Tau Phosphorylation
cytosol
Protein kinase C, alpha/beta/gamma types
[] 
 MAPT
[P10636
re2745
17254575 

11039896 

12022949 

20936779 

mitochondrial outer membrane
Apoptosis
cytosol
GSN
[P06396
 VDAC1
[P21796
re2752
18718443 

Calcium Signalling
cytosol
nucleus
CAPN1
[P07384
 PPARGC1A
[Q9UBK2
re2755
19622774 

Microtubules
cytosol
NDRG1
[Q92597
 BCL2L11
[O43521
re2766
16189514 

10330192 

Ubiquitin Proteasome System
cytosol
STUB1
[Q9UNE7
 HSP70
[Q9Y4L1
re2768
15596450 

cytosolFAF1
[Q9UNN5
 HSP70
[Q9Y4L1
re2775
21144600 

Calcium Signalling
cytosol
GDNF
[P39905],
GFRA1
[P56159
 GFRA1 receptor
[P39905, P56159
re2776
21144600 

Calcium Signalling
cytosol
GFRA1 receptor
[P39905, P56159],
RET
[P07949
 RET receptor tyrosine kinase complex
[P39905, P56159, P07949
re2777
21144600 

Calcium Signalling
cytosol
RET receptor tyrosine kinase complex
[P39905, P56159, P07949
 ERK1 and ERK2 cascade
[] 
re2781
20566846 

Calcium Signalling
cytosol
nucleus
PPARGC1A
[] 
CREB dependent transcription
[] 
PPARGC1A
[] 
re2783
20566846 

Calcium Signalling
cytosol
nucleus
NR4A2
[] 
CREB dependent transcription
[],
PPARGC1A
[Q9UBK2
NR4A2
[] 
re2785
22363463 

cytosol
nucleus
PITX3
[] 
NR4A2
[P43354
PITX3
[] 
re2786
19754401 

cytosol
nucleus
PITX3
[] 
MIR133B
[] 
PITX3
[O75364
re2787
16243425 

19754401 

23341612 

cytosol
nucleus
TH
[] 
PITX3
[O75364],
NR4A2
[P43354
TH
[] 
re2788
19754401 

cytosol
nucleus
GDNF
[] 
PITX3
[O75364
GDNF
[] 
re2789
19754401 

cytosol
nucleus
BDNF
[] 
PITX3
[O75364
BDNF
[] 
re2790
19754401 

cytosol
nucleus
MIR133B
[] 
PITX3
[O75364
MIR133B
[] 
re2794
20566846 

cytosol
nucleus
SOD1
[] 
NR4A2
[P43354
SOD1
[] 
re2795
23341612 

cytosol
nucleus
NDUFB8
[] 
NR4A2
[P43354
NDUFB8
[] 
re2796
23341612 

cytosol
nucleus
COX8A
[] 
NR4A2
[P43354
COX8A
[] 
re2797
23341612 

cytosol
nucleus
COX5B
[] 
NR4A2
[P43354
COX5B
[] 
re2798
23341612 

cytosol
nucleus
COX5A
[] 
NR4A2
[P43354
COX5A
[] 
re2799
23341612 

cytosol
nucleus
COX6A1
[] 
NR4A2
[P43354
COX6A1
[] 
re2800
23341612 

cytosol
nucleus
MRP63
[] 
NR4A2
[P43354
MRP63
[] 
re2801
23341612 

cytosol
nucleus
TSFM
[] 
NR4A2
[P43354
TSFM
[] 
re2802
16243425 

23341612 

cytosol
nucleus
SLC18A2
[] 
NR4A2
[P43354
SLC18A2
[] 
re2803
16243425 

cytosol
nucleus
RET
[] 
NR4A2
[P43354
RET
[] 
re2804
16243425 

cytosol
nucleus
SLC6A3
[] 
NR4A2
[P43354
SLC6A3
[] 
re2805
16243425 

cytosol
nucleus
DDC
[] 
NR4A2
[P43354
DDC
[] 
re2806
19144721 

cytosol
nucleus
DRD2
[] 
NR4A2
[P43354
DRD2
[] 
re2807
19144721 

cytosol
nucleus
VIP
[] 
NR4A2
[P43354
VIP
[] 
re2822
20566846 

cytosol
nucleus
ADCYAP1
[] 
NR4A2
[P43354
ADCYAP1
[] 
re2824
20566846 

cytosol
nucleus
CFLAR
[] 
NR4A2
[P43354
CFLAR
[] 
re2826
20566846 

cytosol
nucleus
ABL2
[] 
NR4A2
[P43354
ABL2
[] 
re2830
20566846 

cytosol
nucleus
SESN3
[] 
NR4A2
[P43354
SESN3
[] 
re2832
20566846 

cytosol
nucleus
ADM
[] 
NR4A2
[P43354
ADM
[] 
re2834
20566846 

cytosol
nucleus
ACVR2B
[] 
NR4A2
[P43354
ACVR2B
[] 
re2836
20566846 

cytosol
nucleus
IGF2BP1
[] 
NR4A2
[P43354
IGF2BP1
[] 
re2838
20566846 

cytosol
nucleus
EIF4EBP2
[] 
NR4A2
[P43354
EIF4EBP2
[] 
re2840
20566846 

cytosol
nucleus
DDX6
[] 
NR4A2
[P43354
DDX6
[] 
re2842
22789442 

cytosol
nucleus
NR4A2
[P43354],
PIN1
[Q13526
 PIN1 NR4A2
[P43354, Q13526
re2843
20566846 

Calcium Signalling
cytosol
ionomycin
[] 
 calcium ion transport into cytosol
[] 
re2844
20566846 

Calcium Signalling
Glutathione metabolism
cytosol
nucleus
response to oxidative stress
[] 
 CREB dependent transcription
[] 
re2845
19754401 

cytosol
nucleus
PITX3
[O75364
 PITX3
[O75364
re2846
23220632 

Calcium Signalling
cytosol
SNCA
[P37840
 ERK1 and ERK2 cascade
[] 
re2847
21144600 

Calcium Signalling
cytosol
RET receptor tyrosine kinase complex
[P39905, P56159, P07949
 Akt pathway
[] 
re2848
23220632 

Calcium Signalling
cytosol
SNCA
[P37840
 Akt pathway
[] 
re2849
23341612 

Calcium Signalling
cytosol
nucleus
NR4A2
[P43354
 NR4A2
[P43354
re2850
18508033 

cytosolGSK3B
[P49841
Akt pathway
[],
rotenone
[] 
GSK3B
[P49841
re2851
22976837 

17670986 

Apoptosis
cytosol
MCL1
[Q07820
GSK3B
[P49841],
MAPK10
[P53779
MCL1
[Q07820
re2852
22976837 

17670986 

Apoptosis
cytosol
MCL1
[Q07820
TRIM17
[Q9Y577
MCL1
[Q07820
re2853
22976837 

17670986 

Apoptosis
cytosol
MCL1
[Q07820
UPS
[] 
s3065
[] 
re2854
22976837 

17670986 

mitochondrial outer membrane
Apoptosis
cytosol
CYCS
[P99999
VDAC1
[P21796
CYCS
[P99999
re2856
17670986 

Apoptosis
cytosol
PIN1
[Q13526],
MCL1
[Q07820
 PIN1 MCL1 Complex
[Q07820, Q13526
re2857
20371704 

Apoptosis
cytosol
BCL2L11
[O43521
GSK3B
[P49841
BCL2L11
[O43521
re2858
20371704 

Apoptosis
cytosol
BAX
[Q07812
GSK3B
[P49841
BAX
[Q07812
re2859
17568190 

mitochondrial outer membrane
cytosol
BCL2L11
[O43521
MAPK8IP3 MAPK10
[Q9UPT6, P53779
BCL2L11
[O43521
re2860
17568190 

mitochondrial outer membrane
cytosol
BCL2L11
[O43521],
PIN1
[Q13526
 BIMEL PIN1
[Q13526, O43521
re2861
16288047 

mitochondrial outer membrane
Apoptosis
cytosol
HK2
[P52789],
VDAC1
[P21796
 HK2:VDAC1
[P21796, P52789
re2862
16288047 

mitochondrial outer membrane
Apoptosis
cytosol
VDAC1
[P21796
GSK3B
[P49841
VDAC1
[P21796
re2863
24167688 

cytosollithium chloride
[CHEBI:48607
 GSK3B
[P49841
re2865
22363258 

24115276 

23461676 

cytosolCTNNB1
[P35222
GSK3B
[P49841],
WNT signalosome
[P56703, P35222, O75197, P54792, O75581, P49841, Q9UP38, Q5S007],
PIN1
[Q13526
CTNNB1
[P35222
re2866
23461676 

cytosolFZD1 receptor
[P04628, Q9UP38
 CTNNB1
[P35222
re2867
23312954 

23461676 

cytosolFZD1 receptor
[P04628, Q9UP38
 GSK3B
[P49841
re2868
23312954 

23461676 

astrocyte
cytosol
FZD1
[Q9UP38],
WNT1
[P04628
astrocyte activation
[] 
FZD1 receptor
[P04628, Q9UP38
re2869
24115276 

cytosolCTNNB1
[P35222
PARK2
[O60260
CTNNB1
[P35222
re2870
24115276 

cytosolCTNNB1
[P35222
 s3088
[] 
re2871
24115276 

cytosol
nucleus
CTNNB1
[P35222
 NR4A2
[P43354
re2872
24115276 

cytosolWNT3
[P56703],
FZD1
[Q9UP38
 WNT signalosome
[P56703, P35222, O75197, P54792, O75581, P49841, Q9UP38, Q5S007
re2875
15228592 

Microtubules
MAPT/Tau Phosphorylation
cytosol
MAPT
[P10636
MAPK10
[P53779],
MAPK9
[P45984],
MAPK1
[P28482
MAPT
[P10636
re2877
21179059 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
NDUFB8
[O95169
 NADH-Q oxireductase (complex I)
[P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404
re2878
21179059 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
COX8A
[P10176
 cytochrome c oxidase (complex IV)
[Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954
re2879
21179059 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
COX5B
[P10606
 cytochrome c oxidase (complex IV)
[Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954
re2880
21179059 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
COX5A
[P20674
 cytochrome c oxidase (complex IV)
[Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954
re2881
21179059 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
COX6A1
[P12074
 cytochrome c oxidase (complex IV)
[Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954
re2882
22976837 

17670986 

mitochondrial outer membrane
Apoptosis
cytosol
MCL1
[Q07820
 intrinsic apoptosis
[] 
re2890
10049997 

17582328 

Calcium Signalling
cytosol
AMPA receptor
[P48058, P42261, P42263, P42262],
L-Glutamate
[CHEBI:29988
 AMPA receptor (Ca impermeable)
[CHEBI:29988, P48058, P42261, P42263, P42262
re2892
17027339 

PINK1 / Parkin Pathway
cytosol
Beta tubulin
[] 
UPS
[] 
s2404
[] 
re2893
21245165 

Microtubules
cytosol
MIR29B2
[] 
 BCL2L11
[O43521
re2920
23149385 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
OXPHOS subunits encoded in mtDNA
[P00156, P03897, P00395, P03901, P00846, P00414, P03923, P00403, P03886, P03928, P03891, P03915, P03905
 NADH-Q oxireductase (complex I)
[P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404
re2921
23149385 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
OXPHOS assembly factors
[] 
 F0F1-ATP synthase (complex V)
[P36542, P48201, P25705, O75947, P30049, Q06055, P56385, O75964, P00846, P48047, Q9UII2, Q7Z4Y8, P05496, P06576, Q5VTU8, P56381, P03928, P18859, P56134, P24539
re2922
23149385 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
OXPHOS assembly factors
[] 
 cytochrome c oxidase (complex IV)
[Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954
re2923
23149385 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
OXPHOS assembly factors
[] 
 ubiquinol, cytochrome-c reductase (complex III)
[CHEBI:26355, P14927, O14957, P07919, Q9Y276, P00156, O14949, CHEBI:30408, P22695, P31930, P47985, P0C7P4, Q9UDW1
re2924
23149385 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
OXPHOS assembly factors
[] 
 NADH-Q oxireductase (complex I)
[P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404
re2925
23149385 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
Glycolysis
cytosol
OXPHOS assembly factors
[] 
 Succinate dehydrogenase (complex II)
[CHEBI:16238, CHEBI:30408, O14521, P21912, Q99643, P31040
re2927
22936770 

mitochondrial outer membrane
PINK1 / Parkin Pathway
mitochondrial inner membrane
cytosol
mitochondrial fusion
[] 
 mitochondrial depolarization
[] 
re2929
22936770 

mitochondrial outer membrane
PINK1 / Parkin Pathway
mitochondrial inner membrane
Fatty Acid / Ketone Body Metabolism
cytosol
mitochondrial fission
[] 
 mtDNA damage
[] 
re2930
22936770 

mitochondrial outer membrane
PINK1 / Parkin Pathway
mitochondrial inner membrane
Fatty Acid / Ketone Body Metabolism
cytosol
mitochondrial fusion
[] 
 mtDNA damage
[] 
re2931
16012194 

16012193 

17030429 

Postsynaptic terminal
GABAergic Neuron
ADORA2A
[P29274
 DRD2
[P14416
re2932
17030429 

Postsynaptic terminal
Dopamine Secretion / Recycling
GABAergic Neuron
caffeine
[CHEBI:27732
 ADORA2A
[P29274
re2934
17030429 

Postsynaptic terminal
GABAergic Neuron
A2A receptor antagonist
[] 
 ADORA2A
[P29274
re2935
17030429 

Postsynaptic terminal
Dopamine Secretion / Recycling
GABAergic Neuron
dopamine
[CHEBI:18243
 DRD2
[P14416
re2936
17618524 

16518376 

Postsynaptic terminal
GABAergic Neuron
GNAL
[P38405
 adenylate cyclase activity
[] 
re2937
17618524 

Postsynaptic terminal
GABAergic Neuron
DRD2
[P14416
 adenylate cyclase activity
[] 
re2938
16518376 

Postsynaptic terminal
GABAergic Neuron
adenylate cyclase activity
[] 
 cAMP
[CHEBI:17489
re2939
16518376 

Postsynaptic terminal
GABAergic Neuron
cAMP
[CHEBI:17489
 PKA
[] 
re2940
16518376 

Postsynaptic terminal
GABAergic Neuron
PKA
[] 
 CREB dependent transcription
[] 
re2942
16518376 

Postsynaptic terminal
GABAergic Neuron
ADORA2A
[P29274
 PI3K cascade
[] 
re2943
10999947 

16518376 

Postsynaptic terminal
GABAergic Neuron
ADORA2A
[P29274
 GNAL
[P38405
re2944
17030429 

Postsynaptic terminal
Dopamine Secretion / Recycling
GABAergic Neuron
adenosine
[CHEBI:16335
 ADORA2A
[P29274
re2948
15262965 

19427899 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
O2
[CHEBI:15379
NADH-Q oxireductase (complex I)
[P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404],
ubiquinol, cytochrome-c reductase (complex III)
[CHEBI:26355, P14927, O14957, P07919, Q9Y276, P00156, O14949, CHEBI:30408, P22695, P31930, P47985, P0C7P4, Q9UDW1],
rotenone
[],
myxothiazol
[] 
superoxide
[CHEBI:18421
re2950
15502874 

10747881 

16247008 

22424229 

11588178 

15358157 

Alpha-synuclein / Lewy Bodies
cytosol
misfolded
[P37840
ROS
[CHEBI:26523],
NO
[CHEBI:16480],
PARK7
[Q99497],
geldanamycin
[] 
protofibril
[P37840
re2953
20566846 

cytosol
nucleus
PRKAA2
[P54646
NR4A2
[P43354
PRKAA2
[P54646
re2954
21248133 

microglia
Microglia
cytosol
neuron death
[] 
 cell surface PRR signaling pathway
[] 
re2955
16810255 

cytosol26S proteasome
[],
Actin-related protein
[] 
NMDA receptor complex
[CHEBI:15428, Q13224, Q14957, Q15334, Q13554, Q9UQM7, Q12879, P35609, CHEBI:29988, O15399, Q99996, Q05586, P07196, Q13555, Q13557
anchored proteasome
[] 
re2956
21068725 

mitochondrial outer membrane
mitochondrial inner membrane
cytosol
SLC25A27
[O95847
 SLC25A27
[O95847
re2962
11780125 

mitochondrial outer membrane
mitochondrial inner membrane
cytosol
superoxide
[CHEBI:18421
 UCP2
[P55851
re2963
11780125 

mitochondrial outer membrane
mitochondrial inner membrane
cytosol
superoxide
[CHEBI:18421
 UCP3
[P55916
re2964
21252228 

PINK1 / Parkin Pathway
cytosol
mitophagy
[] 
SNCA
[P37840
neuron death
[] 
re2965
20566846 

Calcium Signalling
cytosol
L-glutamate
[CHEBI:29988
 calcium ion transport into cytosol
[] 
re2966
20395553 

Postsynaptic terminal
GABAergic Neuron
DRD1
[P21728
PRKCD
[Q05655
DRD1
[P21728
re2968
17680003 

17610816 

Calcium Signalling
cytosol
PRDX2
[P32119
CDK5-p25
[Q15078, Q00535
PRDX2
[P32119
re2969
21600237 

17680003 

17610816 

Calcium Signalling
cytosol
CDK5-p35
[Q15078, Q00535
CAPN1
[P07384],
MPP+
[] 
CDK5-p25
[Q15078, Q00535
re2978
21593323 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
GSS
[] 
NFE2L2
[Q16236
GSS
[] 
re2979
21593323 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
SLC1A1
[] 
NFE2L2
[Q16236
SLC1A1
[] 
re2980
21593323 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
GGT1
[] 
NFE2L2
[Q16236
GGT1
[] 
re2981
21593323 

ROS-dependent NFE2L2 Signalling
cytosol
nucleus
GSTP1
[] 
NFE2L2
[Q16236
GSTP1
[] 
re2985
23766857 

ROS-dependent NFE2L2 Signalling
cytosol
PARK7
[Q99497
ROS/RNS
[] 
PARK7
[Q99497
re2986
23766857 

ROS-dependent NFE2L2 Signalling
cytosol
PARK7
[Q99497
ROS/RNS
[] 
PARK7
[Q99497
re2987
23766857 

ROS-dependent NFE2L2 Signalling
cytosol
PARK7
[Q99497
ROS/RNS
[] 
UPS
[] 
re2988
23766857 

ROS-dependent NFE2L2 Signalling
cytosol
KEAP1
[Q14145],
PARK7
[Q99497
 PARK7-KEAP1
[Q99497, Q14145
re2989
22492997 

23766857 

ROS-dependent NFE2L2 Signalling
cytosol
PARK7
[Q99497],
KEAP1
[Q14145
 PARK7-KEAP1
[Q99497, Q14145
re2990
10064598 

21351850 

11279197 

22539231 

Inflammation Signalling / Apoptosis
Apoptosis
cytosol
GSTP1
[P09211],
MAPK8
[P45983
ROS
[CHEBI:26523],
MPP+
[] 
JNK-GSTP1
[P09211, P45983
re2993
16636664 

22539231 

Apoptosis
cytosol
GSTP1
[P09211],
TRAF2
[Q12933
 TRAF2-GSTP1
[P09211, Q12933
re2994
16636664 

22539231 

Inflammation Signalling / Apoptosis
Apoptosis
cytosol
TRAF2
[Q12933
 TRAF2:TRAF6
[Q9Y4K3, Q12933
re2995
15983381 

20014998 

23766857 

22066468 

Inflammation Signalling / Apoptosis
nucleus
cytosol
PARK-DAXX
[Q99497, Q9UER7
ROS
[CHEBI:26523
PARK7
[Q99497],
DAXX
[Q9UER7
re2996
15983381 

16636664 

23766857 

22066468 

Inflammation Signalling / Apoptosis
cytosol
DAXX
[Q9UER7],
MAP3K5
[Q99683
 ASK1-DAXX
[Q9UER7, Q99683
re2997
15983381 

23766857 

Inflammation Signalling / Apoptosis
cytosol
ASK1-DAXX
[Q9UER7, Q99683
 apoptosis
[] 
re3000
22540427 

23665395 

20481548 

Calcium Signalling
cytosol
GSTP1
[P09211
ROS/RNS
[] 
GSTP1
[P09211
re3001
18990698 

22540427 

21351850 

Calcium Signalling
cytosol
GSTP1
[P09211
ROS/RNS
[] 
UPS
[] 
re3005
24563857 

24396728 

Ubiquitin Proteasome System
cytosol
glutathione
[CHEBI:16856],
26S hybrid proteasome
[Q15008, O00487, O00233, Q16186, P17980, P28070, P62191, O00231, O14818, P49720, P25788, P28074, Q99436, Q99460, P28066, P28072, P60900, P25787, P49721, P62195, P51665, O43242, P25786, P55036, P25789, P43686, O00232, P62333, P20618, P48556, P35998, Q13200
ROS
[CHEBI:26523
26S hybrid proteasome
[P28066
re3006
15790530 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
Glutathione metabolism
cytosol
MPP+
[] 
 Acetylated NADH-Q oxireductase (complex I)
[P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404
re3007
23283974 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
glutathione
[CHEBI:16856
SLC25A11
[Q02978],
SLC25A10
[Q9UBX3
glutathione
[CHEBI:16856
re3114
24145751 

astrocyte
Glutathione metabolism
Blood-Brain Barrier
L-glutamic acid
[CHEBI:16015
SLC7A11
[Q9UPY5
L-glutamic acid
[CHEBI:16015
re3115
23025925 

24145751 

astrocyte
Glutathione metabolism
glycine
[CHEBI:15428],
yGluCys
[] 
GSS
[P48637
glutathione
[CHEBI:16856
re3116
23025925 

21593323 

24145751 

18400456 

astrocyte
Calcium Signalling
Glutathione metabolism
glutathione
[CHEBI:16856
ABCB1
[P08183
glutathione
[CHEBI:16856
re3117
23025925 

21593323 

11746430 

23201762 

24145751 

astrocyte
Calcium Signalling
Glutathione metabolism
glutathione
[CHEBI:16856
GGT1
[P19440
CysGly
[] 
re3118
21593323 

11746430 

23201762 

Calcium Signalling
Glutathione metabolism
cytosol
CysGly
[] 
ANPEP
[P15144
L-cysteine
[CHEBI:17561
re3119
23025925 

24145751 

Glutathione metabolism
cytosol
L-cysteine
[CHEBI:17561],
L-glutamic acid
[CHEBI:16015
GCLM
[P48507],
GCLC
[P48506
yGluCys
[] 
re3120
23025925 

24145751 

Glutathione metabolism
cytosol
glycine
[CHEBI:15428],
yGluCys
[] 
GSS
[P48637
glutathione
[CHEBI:16856
re3121
23025925 

21593323 

23201762 

24145751 

Glutathione metabolism
cytosol
L-cysteine
[CHEBI:17561
SLC1A1
[P43005
L-cysteine
[CHEBI:17561
re3122
18093171 

Glutathione metabolism
cytosol
MPP+
[] 
 SLC1A1
[P43005
re3123
15790530 

Glutathione metabolism
cytosol
MPP+
[] 
SLC6A3
[Q01959
MPP+
[] 
re3124
18786560 

24145751 

Glutathione metabolism
cytosol
MPP-SG
[] 
drug transmembrane transporter activity
[] 
MPP-SG
[] 
re3125
23665395 

Glutathione metabolism
cytosol
glutathione
[CHEBI:16856],
MPP+
[] 
GSTP1
[P09211
MPP-SG
[] 
re3126
15790530 

astrocyte
Glutathione metabolism
blood vessel
Blood-Brain Barrier
MTPT
[] 
 MTPT
[] 
re3127
15790530 

astrocyte
mitochondrion
Glutathione metabolism
MTPT
[] 
MAOB:FAD
[CHEBI:16238, P27338
MPP+
[] 
re3128
15790530 

astrocyte
Glutathione metabolism
MPP+
[] 
 MPP+
[] 
re3129
22540427 

23665395 

21351850 

22066468 

18400456 

Glutathione metabolism
cytosol
glutathione
[CHEBI:16856],
generic protein
[] 
GSTP1
[P09211
generic protein
[] 
re3130
18786560 

24145751 

Glutathione metabolism
cytosol
generic protein
[] 
drug transmembrane transporter activity
[] 
generic protein
[] 
re3131
22540427 

24145751 

Glutathione metabolism
cytosol
generic protein
[] 
ROS/RNS
[] 
generic protein
[] 
re3132
18331844 

22530666 

21351850 

24145751 

18400456 

22066468 

17098212 

Glutathione metabolism
cytosol
generic protein
[] 
GLRX
[P35754],
TRX
[P10599],
GLRX2
[Q9NS18
generic protein
[],
glutathione disulfide
[CHEBI:17858
re3133
23665395 

Glutathione metabolism
cytosol
glutathione
[CHEBI:16856],
paraquat
[] 
GSTP1
[P09211
Paraquat-SG
[] 
re3134
18786560 

24145751 

Glutathione metabolism
cytosol
Paraquat-SG
[] 
drug transmembrane transporter activity
[] 
Paraquat-SG
[] 
re3135
23665395 

Glutathione metabolism
cytosol
electrophile
[],
glutathione
[CHEBI:16856
GSTP1
[P09211
electrophile-SG
[] 
re3136
18786560 

24145751 

Glutathione metabolism
cytosol
electrophile-SG
[] 
drug transmembrane transporter activity
[] 
electrophile-SG
[] 
re3145
22369136 

23201762 

24145751 

endothelial cell
Glutathione metabolism
Blood-Brain Barrier
cystine
[CHEBI:17376
SLC7A5
[Q01650
cystine
[CHEBI:17376
re3146
22369136 

23201762 

24145751 

endothelial cell
blood vessel
Blood-Brain Barrier
cystine
[CHEBI:17376
SLC7A11
[Q9UPY5
cystine
[CHEBI:17376
re3147
22540427 

Glutathione metabolism
cytosol
generic protein
[] 
ROS/RNS
[] 
UPS
[] 
re3148
18400456 

Glutathione metabolism
cytosol
glutathione
[CHEBI:16856],
electrophile
[] 
 electrophile-SG
[] 
re3149
24457173 

astrocyte
blood vessel
Blood-Brain Barrier
glucose
[CHEBI:17234
GLUT1
[P11166
glucose
[CHEBI:17234
re3150
24457173 

astrocyte
Blood-Brain Barrier
glucose
[CHEBI:17234
 (S)-lactate
[CHEBI:16651
re3153
23025925 

22369136 

24145751 

astrocyte
Glutathione metabolism
Blood-Brain Barrier
cystine
[CHEBI:17376
SLC7A11
[Q9UPY5],
SLC3A2
[P08195
cystine
[CHEBI:17376
re3154
23025925 

24145751 

astrocyte
Glutathione metabolism
Blood-Brain Barrier
cystine
[CHEBI:17376
 L-cysteine
[CHEBI:17561
re3155
23025925 

24145751 

astrocyte
Glutathione metabolism
Blood-Brain Barrier
L-cysteine
[CHEBI:17561],
L-glutamic acid
[CHEBI:16015
GCLM
[P48507],
GCLC
[P48506
yGluCys
[] 
re3156
18093171 

9745361 

24145751 

Glutathione metabolism
cytosol
ROS/RNS
[] 
 SLC1A1
[P43005
re3168
24457173 

astrocyte
Glycolysis
cytosol
(S)-lactate
[CHEBI:16651
GLUT1
[P11166],
GLUT3
[P11169
(S)-lactate
[CHEBI:16651
re3169
22492997 

23766857 

ROS-dependent NFE2L2 Signalling
cytosol
KEAP1:CUL3
[Q13618, Q14145
 KEAP1
[Q14145],
CUL3
[Q13618
re3170
22066468 

Glutathione metabolism
cytosol
generic protein
[],
TRX
[P10599
 generic protein
[],
TRX
[P10599
re3171
23283974 

mitochondrial outer membrane
cytosol
glutathione
[CHEBI:16856
 glutathione
[CHEBI:16856
re3177
22503440 

microglia
Microglia
NADPH oxidase complex
[P04839, P14598, Q9HBY0
 superoxide
[CHEBI:18421
re3178
20195798 

15998743 

superoxide
[CHEBI:18421],
NO
[CHEBI:16480
 peroxynitrite
[CHEBI:25941
re3179
24455696 

20195798 

15998743 

superoxide
[CHEBI:18421
 ROS
[CHEBI:26523
re3180
24455696 

20195798 

15998743 

peroxynitrite
[CHEBI:25941
 ROS
[CHEBI:26523
re3181
21982369 

Alpha-synuclein spreading
cytosol
protofibril
[P37840
pinocytosis
[] 
protofibril
[P37840
re3184
23683503 

16791599 

astrocytedopamine
[CHEBI:18243
COMT
[P21964
3-O-Methyldopamine
[CID 1669
re3185
23683503 

16791599 

astrocyte3-O-Methyldopamine
[CID 1669
MAOA:FAD
[P21397, CHEBI:16238],
MAOB:FAD
[CHEBI:16238, P27338
homovanillin
[] 
re3186
23683503 

17379813 

16791599 

astrocytedopamine
[CHEBI:18243
MAOA:FAD
[P21397, CHEBI:16238],
MAOB:FAD
[CHEBI:16238, P27338
DOPAL
[CHEBI:27978
re3187
23683503 

17379813 

16791599 

astrocyteDOPAL
[CHEBI:27978
ALDH1A1
[P00352],
ALDH3A1
[P30838],
ALDH9A1
[P49189],
ALDH2
[P05091
DOPAC
[CHEBI:41941
re3188
23683503 

16791599 

astrocytehomovanillin
[] 
ALDH1A1
[P00352],
ALDH2
[P05091],
ALDH3A1
[P30838],
ALDH9A1
[P49189
homovanillic acid
[CHEBI:545959
re3189
23683503 

16791599 

astrocyteDOPAC
[CHEBI:41941
COMT
[P21964
homovanillic acid
[CHEBI:545959
re3190
20195798 

15998743 

microglia
Microglia
superoxide
[CHEBI:18421],
NO
[CHEBI:16480
 peroxynitrite
[CHEBI:25941
re3191
20566846 

Calcium Signalling
cytosol
nucleus
calcium ion transport into cytosol
[] 
 CREB dependent transcription
[] 
re3192
20566846 

Calcium Signalling
cytosol
calcium ion transport into cytosol
[] 
 Ca2+
[CHEBI:29108
re3193
24563857 

24396728 

Ubiquitin Proteasome System
cytosol
26S hybrid proteasome
[P28066
 UPS
[] 
re3218
23149385 

mitochondrial outer membrane
mitochondrial inner membrane
nucleoid
cytosol
mitochondrial DNA
[] 
mitochondrial transcription
[] 
mRNA
[] 
re3219
17280879 

17227870 

23149385 

mitochondrial outer membrane
mitochondrial inner membrane
nucleoid
cytosol
mitochondrial DNA
[] 
Mt-dNTP pool
[P53597, Q16854, Q7LG56, Q9P2R7, O00142],
mtDNA damage
[],
TFAM
[Q00059],
Mt replication
[Q9NVV4, P54098, Q96DP5, Q9UHN1
mtDNA replication
[] 
re3220
17280879 

17227870 

23149385 

mitochondrial outer membrane
mitochondrial inner membrane
nucleoid
cytosol
mtDNA repair
[] 
Mt-DNA repair
[Q13216, P54098, Q03468],
Mt-dNTP pool
[P53597, Q16854, Q7LG56, Q9P2R7, O00142],
TFAM
[Q00059
mitochondrial DNA
[] 
re3222
17280879 

mitochondrial outer membrane
mitochondrial inner membrane
nucleoid
cytosol
TFAM
[Q00059
 mitochondrial DNA
[] 
re3223
23149385 

mitochondrial outer membrane
mitochondrial inner membrane
nucleoid
cytosol
Mt ribosomal proteins
[P82650, P09001, Q9Y3D3
 mitochondrial translation
[] 
re3224
23149385 

mitochondrial outer membrane
mitochondrial inner membrane
nucleoid
cytosol
Mt translation
[P43897, Q96RR1, Q96RP9, Q9H3J6, P49411
 mitochondrial translation
[] 
re3225
23149385 

mitochondrial outer membrane
mitochondrial inner membrane
nucleoid
cytosol
mitochondrial DNA
[] 
Mt tRNA synthetases
[P41250, Q5JTZ9, Q6PI48, Q15046, Q5T160
mitochondrial tRNAs and rRNA
[] 
re3226
23149385 

mitochondrial outer membrane
mitochondrial inner membrane
nucleoid
cytosol
mRNA
[],
mitochondrial tRNAs and rRNA
[] 
mitochondrial translation
[] 
OXPHOS subunits encoded in mtDNA
[P00156, P03897, P00395, P03901, P00846, P00414, P03923, P00403, P03886, P03928, P03891, P03915, P03905
re332
19427899 

20053987 

18245082 

20887775 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
NADH
[CHEBI:16908],
ubiquinone
[CHEBI:46245],
H+
[CHEBI:15378
NADH-Q oxireductase (complex I)
[P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404],
rotenone
[],
SNCA
[P37840],
SNCA
[P37840
NAD(+)
[CHEBI:15846],
H+
[CHEBI:15378],
ubiquinol
[CHEBI:17976
re336
16199211 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
O2
[CHEBI:15379],
CYCS
[P99999],
H+
[CHEBI:15378
cytochrome c oxidase (complex IV)
[Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954
H2O
[CHEBI:15377],
CYCS
[P99999],
H+
[CHEBI:15378
re338
19427899 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial ROS Metabolism
cytosol
O2
[CHEBI:15379
 superoxide
[CHEBI:18421
re339
19427899 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial ROS Metabolism
cytosol
superoxide
[CHEBI:18421],
H+
[CHEBI:15378
SOD2
[P04179
hydrogen peroxide
[CHEBI:16240
re340
19427899 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial ROS Metabolism
cytosol
hydrogen peroxide
[CHEBI:16240
CAT
[P04040
H2O
[CHEBI:15377],
O2
[CHEBI:15379
re341
19427899 

23939310 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial ROS Metabolism
cytosol
hydrogen peroxide
[CHEBI:16240],
TXN
[P10599
PRDX3
[P30048],
PRDX5
[P30044
H2O
[CHEBI:15377],
TXN
[P10599
re342
19427899 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial ROS Metabolism
cytosol
NADPH
[CHEBI:16474],
TXN
[P10599
TXNRD2
[Q9NNW7
NADP(+)
[CHEBI:18009],
TXN
[P10599
re343
19427899 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
O2
[CHEBI:15379
ubiquinol
[CHEBI:17976
superoxide
[CHEBI:18421
re345
19427899 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial ROS Metabolism
cytosol
hydrogen peroxide
[CHEBI:16240],
glutathione
[CHEBI:16856
GPX1
[P07203],
GPX4
[P36969
H2O
[CHEBI:15377],
glutathione disulfide
[CHEBI:17858
re346
19427899 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial ROS Metabolism
cytosol
glutathione disulfide
[CHEBI:17858],
NADPH
[CHEBI:16474
GSR
[P00390
glutathione
[CHEBI:16856],
NADP(+)
[CHEBI:18009
re348
20045723 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial ROS Metabolism
cytosol
superoxide
[CHEBI:18421
 ROS
[CHEBI:26523
re349
20045723 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial ROS Metabolism
cytosol
hydrogen peroxide
[CHEBI:16240
 ROS
[CHEBI:26523
re360
2172697 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial ROS Metabolism
cytosol
hydrogen peroxide
[CHEBI:16240],
Fe2+
[] 
 hydroxyl
[CHEBI:29191],
Fe3+
[],
hydroxide
[CHEBI:16234
re361
20045723 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial ROS Metabolism
cytosol
hydroxyl
[CHEBI:29191
 ROS
[CHEBI:26523
re363
20045723 

mitochondrial outer membrane
Mitochondrial Electron Transport Chain
cytosol
superoxide
[CHEBI:18421
 ROS
[CHEBI:26523
re364
20045723 

mitochondrial outer membrane
Mitochondrial Electron Transport Chain
cytosol
hydrogen peroxide
[CHEBI:16240
 ROS
[CHEBI:26523
re366
2172697 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial ROS Metabolism
cytosol
hydroxyl
[CHEBI:29191],
Fe2+
[] 
 hydroxide
[CHEBI:16234],
Fe3+
[] 
re368
2172697 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial ROS Metabolism
cytosol
hydrogen peroxide
[CHEBI:16240],
hydroxyl
[CHEBI:29191
 superoxide
[CHEBI:18421],
H2O
[CHEBI:15377],
H+
[CHEBI:15378
re369
2172697 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial ROS Metabolism
cytosol
superoxide
[CHEBI:18421],
Fe3+
[] 
 O2
[CHEBI:15379],
Fe2+
[] 
re372
19427899 

18189325 

mitochondrial outer membrane
mitochondrial inner membrane
cytosol
ATP-sensitive K+ channel
[Q14654, Q15842
ATP
[CHEBI:15422],
Tiopronin
[CID 5483],
ROS
[CHEBI:26523],
diazoxide
[] 
ATP-sensitive K+ channel
[Q14654, Q15842
re373
18189325 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
K+
[CHEBI:29103
ATP-sensitive K+ channel
[Q14654, Q15842
K+
[CHEBI:29103
re374
19427899 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
ATP-sensitive K+ channel
[Q14654, Q15842
 mitochondrial depolarization
[] 
re377
19427899 

mitochondrial outer membrane
Mitochondrial Electron Transport Chain
cytosol
H+
[CHEBI:15378
 H+
[CHEBI:15378
re378
19427899 

mitochondrial outer membrane
Mitochondrial Electron Transport Chain
cytosol
H+
[CHEBI:15378
 H+
[CHEBI:15378
re379
19427899 

mitochondrial outer membrane
Mitochondrial Electron Transport Chain
cytosol
H+
[CHEBI:15378
 H+
[CHEBI:15378
re39
16791599 

Dopamine Metabolism
cytosol
dopamine
[CHEBI:18243
COMT
[P21964
3-O-Methyldopamine
[CID 1669
re40
16791599 

mitochondrion
Dopamine Metabolism
cytosol
3-O-Methyldopamine
[CID 1669
MAOA:FAD
[P21397, CHEBI:16238],
MAOB:FAD
[CHEBI:16238, P27338
homovanillin
[] 
re41
17379813 

16791599 

mitochondrion
Dopamine Metabolism
cytosol
dopamine
[CHEBI:18243],
H2O
[CHEBI:15377],
O2
[CHEBI:15379
MAOA:FAD
[P21397, CHEBI:16238],
MAOB:FAD
[CHEBI:16238, P27338
DOPAL
[CHEBI:27978],
hydrogen peroxide
[CHEBI:16240],
ammonia
[CHEBI:16134
re42
17379813 

16791599 

Dopamine Metabolism
cytosol
DOPAL
[CHEBI:27978
ALDH1A1
[P00352],
ALDH3A1
[P30838],
ALDH9A1
[P49189],
ALDH2
[P05091
DOPAC
[CHEBI:41941
re424
20045723 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial ROS Metabolism
cytosol
hydrogen peroxide
[CHEBI:16240
 ROS
[CHEBI:26523
re425
20045723 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial ROS Metabolism
cytosol
superoxide
[CHEBI:18421
 ROS
[CHEBI:26523
re43
16791599 

Dopamine Metabolism
cytosol
homovanillin
[] 
ALDH1A1
[P00352],
ALDH2
[P05091],
ALDH3A1
[P30838],
ALDH9A1
[P49189
homovanillic acid
[CHEBI:545959
re44
16791599 

Dopamine Metabolism
cytosol
DOPAC
[CHEBI:41941
COMT
[P21964
homovanillic acid
[CHEBI:545959
re45
16791599 

Dopamine Metabolism
cytosol
DOPAL
[CHEBI:27978
AKR1A1
[P14550],
AKR1B1
[P15121
DOPET
[CID 82755
re510
18931687 

Apoptosis
cytosol
Caspase-2
[P42575
 CYCS
[P99999
re512
18931687 

Apoptosis
cytosol
CASP9
[P55211
AKT1
[P31749
CASP9
[P55211
re513
18931687 

12792650 

Apoptosis
cytosol
CASP9
[P55211
MAPK1
[P28482
CASP9
[P55211
re620
17883330 

18206122 

22066468 

Inflammation Signalling / Apoptosis
cytosol
Thioredoxin:ASK1
[P10599, Q99683
ROS
[CHEBI:26523
TXN
[P10599],
MAP3K5
[Q99683
re621
18206122 

Inflammation Signalling / Apoptosis
cytosol
MAP3K5
[Q99683],
TRAF2:TRAF6
[Q9Y4K3, Q12933],
TRAF2:TRAF6
[Q9Y4K3, Q12933
 ASK1 signalsome
[Q99683, Q9Y4K3, Q12933
re622
18206122 

Inflammation Signalling / Apoptosis
cytosol
ASK1 signalsome
[Q99683, Q9Y4K3, Q12933
ASK1 signalsome
[Q99683, Q9Y4K3, Q12933
ASK1 signalsome
[Q99683, Q9Y4K3, Q12933
re623
18206122 

Inflammation Signalling / Apoptosis
cytosol
ASK1 signalsome
[Q99683, Q9Y4K3, Q12933
PPP5C
[P53041
ASK1 signalsome
[Q99683, Q9Y4K3, Q12933
re624
19629069 

Inflammation Signalling / Apoptosis
Apoptosis
cytosol
MAP2K4
[P45985
ASK1 signalsome
[Q99683, Q9Y4K3, Q12933],
MAP3K7
[O43318
MAP2K4
[P45985
re625
19629069 

Inflammation Signalling / Apoptosis
Apoptosis
cytosol
MAP2K7
[O14733
ASK1 signalsome
[Q99683, Q9Y4K3, Q12933],
MAP3K7
[O43318
MAP2K7
[O14733
re626
19629069 

Apoptosis
cytosol
MAPK8
[P45983
MAP2K4
[P45985],
MAP2K7
[O14733
MAPK8
[P45983
re627
19629069 

Apoptosis
cytosol
MAPK9
[P45984
MAP2K4
[P45985],
MAP2K7
[O14733
MAPK9
[P45984
re628
19629069 

Apoptosis
cytosol
MAPK10
[P53779
MAP2K4
[P45985],
MAP2K7
[O14733
MAPK10
[P53779
re629
19629069 

Apoptosis
cytosol
MAPK14
[Q16539
MAP2K4
[P45985],
MAP2K7
[O14733],
MAP2K3
[P46734],
MAP2K6
[P52564
MAPK14
[Q16539
re630
17303404 

mitochondrial outer membrane
Apoptosis
cytosol
MAPK8
[P45983
 BAX
[Q07812
re631
17303404 

mitochondrial outer membrane
Apoptosis
cytosol
MAPK9
[P45984
 BAX
[Q07812
re632
17303404 

mitochondrial outer membrane
Apoptosis
cytosol
MAPK10
[P53779
 BAX
[Q07812
re633
17303404 

mitochondrial outer membrane
Apoptosis
cytosol
MAPK8
[P45983
 BAK1
[Q16611
re634
17303404 

mitochondrial outer membrane
Apoptosis
cytosol
MAPK9
[P45984
 BAK1
[Q16611
re635
17303404 

mitochondrial outer membrane
Apoptosis
cytosol
MAPK10
[P53779
 BAK1
[Q16611
re637
21068725 

cytosolROS
[CHEBI:26523
 PARK7
[Q99497
re638
15071501 

Apoptosis
cytosol
14-3-3 zeta:Bax
[Q07812, P63104
MAPK8
[P45983
YWHAZ
[P63104],
BAX
[Q07812
re639
15071501 

Apoptosis
cytosol
14-3-3 sigma:Bax
[P31947, Q07812
MAPK8
[P45983
SFN
[P31947],
BAX
[Q07812
re655
19427899 

mitochondrial outer membrane
Mitochondrial Electron Transport Chain
cytosol
superoxide
[CHEBI:18421],
H+
[CHEBI:15378
SOD1
[P00441
hydrogen peroxide
[CHEBI:16240
re658
18710944 

Apoptosis
cytosol
BAX
[Q07812],
XRCC6
[P12956
 Ku70:BAX complex
[Q07812, P12956
re659
18710944 

Apoptosis
cytosol
XRCC6
[P12956
SIRT3
[Q9NTG7
XRCC6
[P12956
re66
16030137 

Alpha-synuclein / Lewy Bodies
Dopamine Metabolism
cytosol
SNCA
[P37840
 PP2A
[P67775, P62714
re67
16030137 

Dopamine Metabolism
cytosol
Tyrosine 3-monooxygenase (Fe2+ cofactor)
[] 
PP2A
[P67775, P62714
Tyrosine 3-monooxygenase (Fe2+ cofactor)
[] 
re68
10747881 

16247008 

22424229 

11588178 

21841800 

Alpha-synuclein / Lewy Bodies
cytosol
SNCA
[P37840
ROS
[CHEBI:26523],
NO
[CHEBI:16480
misfolded
[P37840
re696
18710944 

20089838 

autophagosome
lysosome
Autophagy / Mitophagy
autolysosome
cytosol
autophagosome
[],
lysosome
[] 
VAMP8
[Q9BV40],
VTI1B
[Q9UEU0
autolysosome
[] 
re697
21884931 

20959619 

autophagosome
Autophagy / Mitophagy
phagophore
cytosol
phagophore
[],
LC3-II
[CHEBI:16038, Q9H492
ATG12:ATG5:ATG16L1
[O94817, Q9H1Y0, Q676U5
autophagosome
[] 
re701
18570871 

Autophagy / Mitophagy
cytosol
BECN1
[Q14457],
PIK3C3
[Q8NEB9],
PIK3R4
[Q99570],
ATG14
[Q6ZNE5],
AMBRA1
[Q9C0C7
 Class-III PI3K complex
[Q9C0C7, Q14457, Q99570, Q8NEB9, Q6ZNE5
re703
22078875 

20959619 

Autophagy / Mitophagy
cytosol
MAP1LC3A (LC3-I)
[Q9H492],
ATG7
[O95352
 LC3-I:ATG7
[O95352, Q9H492
re71
20961626 

19889641 

19004816 

Alpha-synuclein / Lewy Bodies
cytosol
SNCA
[P37840
PLK2
[Q9NYY3],
PLK3
[Q9H4B4
SNCA
[P37840
re717
17347648 

19542216 

15716268 

Calcium Signalling
cytosol
nucleus
PPARGC1A
[Q9UBK2
SIRT1
[Q96EB6
PPARGC1A
[Q9UBK2
re718
22078875 

Apoptosis
cytosol
CASP2
[P42575
PIDDsome
[Q9HB75, P78560
Caspase-2
[P42575
re719
18046414 

Calcium Signalling
cytosol
nucleus
YY1:PGC1-alpha
[P25490, Q9UBK2
 PPARGC1A
[Q9UBK2
re720
18794531 

21658599 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
Acetylated NADH-Q oxireductase (complex I)
[P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404
SIRT3
[Q9NTG7
NADH-Q oxireductase (complex I)
[P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404
re721
20000467 

21658599 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
Glycolysis
cytosol
Acetylated succinate dehydrogenase (complex II)
[CHEBI:16238, CHEBI:30408, O14521, P21912, Q99643, P31040
SIRT3
[Q9NTG7
Succinate dehydrogenase (complex II)
[CHEBI:16238, CHEBI:30408, O14521, P21912, Q99643, P31040
re722
21658599 

21109198 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial ROS Metabolism
cytosol
SOD2
[P04179
SIRT3
[Q9NTG7
SOD2
[P04179
re723
21658599 

Calcium Signalling
cytosol
nucleus
caloric restriction
[] 
 SIRT1
[Q96EB6
re724
21094524 

21658599 

mitochondrial outer membrane
mitochondrial inner membrane
TCA Cycle
cytosol
Acetylated isocitrate dehydrogenase
[] 
SIRT3
[Q9NTG7
isocitrate dehydrogenase
[] 
re725
18680753 

21658599 

mitochondrial outer membrane
mitochondrial inner membrane
Mitochondrial Electron Transport Chain
cytosol
CYCS
[P99999
SIRT5
[Q9NXA8
CYCS
[P99999
re728
21068725 

cytosol
nucleus
SLC25A27
[] 
PARK7
[Q99497
SLC25A27
[] 
re729
21068725 

cytosol
nucleus
SLC25A14
[] 
PARK7
[Q99497
SLC25A14
[] 
re736
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
COX7A1
[] 
PPARGC1A
[Q9UBK2
COX7A1
[] 
re737
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
NDUFB6
[] 
PPARGC1A
[Q9UBK2
NDUFB6
[] 
re738
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
UQCRB
[] 
PPARGC1A
[Q9UBK2
UQCRB
[] 
re739
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
UQCRC1
[] 
PPARGC1A
[Q9UBK2
UQCRC1
[] 
re740
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
ATP5A1
[] 
PPARGC1A
[Q9UBK2
ATP5A1
[] 
re741
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
CYCS
[] 
PPARGC1A
[Q9UBK2
CYCS
[] 
re742
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
COX7C
[] 
PPARGC1A
[Q9UBK2
COX7C
[] 
re743
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
COX7A2L
[] 
PPARGC1A
[Q9UBK2
COX7A2L
[] 
re744
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
COX7A2
[] 
PPARGC1A
[Q9UBK2
COX7A2
[] 
re746
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
COX6A1
[] 
PPARGC1A
[Q9UBK2
COX6A1
[] 
re747
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
COX5B
[] 
PPARGC1A
[Q9UBK2
COX5B
[] 
re748
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
ATP5O
[] 
PPARGC1A
[Q9UBK2
ATP5O
[] 
re749
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
ATP5L
[] 
PPARGC1A
[Q9UBK2
ATP5L
[] 
re750
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
ATP5D
[] 
PPARGC1A
[Q9UBK2
ATP5D
[] 
re751
21179059 

Calcium Signalling
cytosol
nucleus
ATP5C1
[] 
PPARGC1A
[Q9UBK2
ATP5C1
[] 
re752
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
NDUFA8
[] 
PPARGC1A
[Q9UBK2
NDUFA8
[] 
re753
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
NDUFAB1
[] 
PPARGC1A
[Q9UBK2
NDUFAB1
[] 
re754
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
NDUFB3
[] 
PPARGC1A
[Q9UBK2
NDUFB3
[] 
re755
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
NDUFB5
[] 
PPARGC1A
[Q9UBK2
NDUFB5
[] 
re756
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
COX7B
[] 
PPARGC1A
[Q9UBK2
COX7B
[] 
re757
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
NDUFC1
[] 
PPARGC1A
[Q9UBK2
NDUFC1
[] 
re758
21179059 

Calcium Signalling
cytosol
nucleus
NDUFS3
[] 
PPARGC1A
[Q9UBK2
NDUFS3
[] 
re759
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
NDUFS5
[] 
PPARGC1A
[Q9UBK2
NDUFS5
[] 
re760
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
SDHA
[] 
PPARGC1A
[Q9UBK2
SDHA
[] 
re761
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
SDHB
[] 
PPARGC1A
[Q9UBK2
SDHB
[] 
re762
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
SLC25A4
[] 
PPARGC1A
[Q9UBK2
SLC25A4
[] 
re763
21179059 

18046414 

Calcium Signalling
cytosol
nucleus
SLC25A5
[] 
PPARGC1A
[Q9UBK2
SLC25A5
[] 
re766
20045723 

mitochondrial outer membrane
mitochondrial inner membrane
cytosol
membrane permeability
[] 
 mitochondrial dysfunction
[] 
re769
20098416 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
VDAC1
[P21796
PINK1:PARK2
[O60260, Q9BXM7
VDAC1
[P21796
re774
21179058 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
mitochondrial depolarization
[] 
 mitophagy
[] 
re775
21376232 

PINK1 / Parkin Pathway
cytosol
ZNF746
[Q6NUN9
PARK2
[O60260
ZNF746
[Q6NUN9
re776
21376232 

PINK1 / Parkin Pathway
cytosol
ZNF746
[Q6NUN9
UPS
[] 
s2404
[] 
re777
21376232 

Calcium Signalling
cytosol
nucleus
PPARGC1A
[] 
ZNF746
[Q6NUN9],
CREB dependent transcription
[] 
PPARGC1A
[] 
re782
21127245 

Autophagy / Mitophagy
autolysosome
cytosol
autolysosome
[] 
 amino acid
[CHEBI:33709
re783
21258367 

Calcium Signalling
cytosol
ULK1 complex
[O75143, Q8TDY2, Q9BSB4, O75385
 autophagy
[] 
re784
21258367 

Calcium Signalling
cytosol
ATG1 kinase complex
[O75143, Q8TDY2, Q9BSB4, O75385
mTOR complex 1 (mTORC1)
[Q8N122, Q96B36, Q8TB45, P42345, Q9BVC4
ATG1 kinase complex
[O75143, Q8TDY2, Q9BSB4, O75385
re791
21157483 

Calcium Signalling
cytosol
TSC2
[P49815
 mTOR complex 1 (mTORC1)
[Q8N122, Q96B36, Q8TB45, P42345, Q9BVC4
re792
21157483 

Calcium Signalling
cytosol
amino acid
[CHEBI:33709
 Ragulator:RAGA:RAGC
[Q9UHA4, Q9Y2Q5, Q9NQL2, Q9HB90, Q6IAA8, Q7L523, Q5VZM2
re796
21157483 

Calcium Signalling
cytosol
Ragulator:RAGA:RAGC
[Q9UHA4, Q9Y2Q5, Q9NQL2, Q9HB90, Q6IAA8, Q7L523, Q5VZM2
 mTOR complex 1 (mTORC1)
[Q8N122, Q96B36, Q8TB45, P42345, Q9BVC4
re800
18046414 

Calcium Signalling
cytosol
nucleus
mTOR complex 1 (mTORC1)
[Q8N122, Q96B36, Q8TB45, P42345, Q9BVC4
 YY1:PGC1-alpha
[P25490, Q9UBK2
re802
9308896 

mitochondrial outer membrane
cytosol
peroxynitrite
[CHEBI:25941
 membrane permeability
[] 
re805
21157483 

Calcium Signalling
cytosol
rapamycin
[] 
 mTOR complex 1 (mTORC1)
[Q8N122, Q96B36, Q8TB45, P42345, Q9BVC4
re807
20098416 

19029340 

mitochondrial outer membrane
PINK1 / Parkin Pathway
cytosol
PARK2
[O60260],
PINK1
[Q9BXM7
CCCP
[],
ROS
[CHEBI:26523
PINK1:PARK2
[O60260, Q9BXM7
re808
19461077 

mitochondrial outer membrane
Apoptosis
cytosol
VDAC1
[P21796],
BCL2
[P10415
 BCL2:VDAC1
[P21796, P10415
re809
19461077 

mitochondrial outer membrane
Apoptosis
cytosol
VDAC1
[P21796
intrinsic apoptosis
[] 
VDAC1
[P21796
re810
19427899 

mitochondrial outer membrane
mitochondrial inner membrane
cytosol
Ca2+
[CHEBI:29108
MICU1
[Q9BPX6
Ca2+
[CHEBI:29108
re811
18566453 

22014436 

15333840 

Alpha-synuclein / Lewy Bodies
lysosome
cytosol
misfolded
[P37840
LAMP2
[P13473],
HSPA8
[P11142],
SNCA
[P37840],
SNCA
[P37840
misfolded
[P37840
re812
23079555 

21700325 

Alpha-synuclein / Lewy Bodies
lysosome
cytosol
misfolded
[P37840
GBA:PSAP
[P04062, P07602],
CTSD
[P07339
s1831
[] 
re813
17803915 

Dopamine Secretion / Recycling
cytosol
RIMS1
[Q86UR5
SCF complex
[Q13616, P63208, Q96IG2
RIMS1
[Q86UR5
re82
16495942 

mitochondrial outer membrane
mitochondrial inner membrane
cytosol
mitochondrial dysfunction
[] 
 intrinsic apoptosis
[] 
re84
19427899 

mitochondrial outer membrane
mitochondrial inner membrane
cytosol
ROS
[CHEBI:26523
 mitochondrial dysfunction
[] 
re884
21109197 

mitochondrial outer membrane
mitochondrial inner membrane
TCA Cycle
cytosol
HMGCS2
[P54868
SIRT3
[Q9NTG7
HMGCS2
[P54868
re890
16959573 

mitochondrial outer membrane
mitochondrial inner membrane
TCA Cycle
cytosol
GLUD1
[P00367
SIRT4
[Q9Y6E7
GLUD1
[P00367
re891
16959573 

mitochondrial outer membrane
mitochondrial inner membrane
TCA Cycle
cytosol
caloric restriction
[] 
 SIRT4
[Q9Y6E7
re892
18680753 

mitochondrial outer membrane
mitochondrial inner membrane
TCA Cycle
cytosol
GLUD1
[P00367
SIRT3
[Q9NTG7
GLUD1
[P00367
re904
12392933 

Calcium Signalling
cytosol
Na+
[CHEBI:29101
 membrane depolarlization
[] 
re905
12392933 

Calcium Signalling
cytosol
Ca2+
[CHEBI:29108
 membrane depolarlization
[] 
re924
20842175 

Calcium Signalling
cytosol
MAPK1
[P28482
 MAPK1
[P28482
re926
21157483 

Calcium Signalling
cytosol
AMPK
[Q9Y478, Q9UGJ0, P54646, Q9UGI9, O43741, P54619, Q13131
 TSC2
[P49815
re933
20842175 

Calcium Signalling
cytosol
nucleus
ATF3
[] 
CREB dependent transcription
[] 
ATF3
[] 
re934
20842175 

Calcium Signalling
cytosol
nucleus
BTG2
[] 
CREB dependent transcription
[] 
BTG2
[] 
re935
20842175 

Calcium Signalling
cytosol
nucleus
BCL6
[] 
CREB dependent transcription
[] 
BCL6
[] 
re936
20842175 

Calcium Signalling
cytosol
nucleus
GADD45B
[] 
CREB dependent transcription
[] 
GADD45B
[] 
re937
20842175 

Calcium Signalling
cytosol
nucleus
GADD45G
[] 
CREB dependent transcription
[] 
GADD45G
[] 
re938
20842175 

Calcium Signalling
cytosol
nucleus
INHBA
[] 
CREB dependent transcription
[] 
INHBA
[] 
re940
20842175 

Calcium Signalling
cytosol
nucleus
NPAS4
[] 
CREB dependent transcription
[] 
NPAS4
[] 
re941
20842175 

Calcium Signalling
cytosol
nucleus
NR4A1
[] 
CREB dependent transcription
[] 
NR4A1
[] 
re942
20842175 

Calcium Signalling
cytosol
nucleus
SERPINB2
[] 
CREB dependent transcription
[] 
SERPINB2
[] 
re943
20842175 

Calcium Signalling
cytosol
nucleus
BDNF
[] 
CREB dependent transcription
[] 
BDNF
[] 
re944
20842175 

Calcium Signalling
cytosol
nucleus
CREB1
[P16220],
CREBBP
[Q92793
 CREB:CBP
[Q92793, P16220
re945
20842175 

Calcium Signalling
cytosol
nucleus
CREBBP
[Q92793
Calmodulin:CaMK IV
[P62158, CHEBI:29108, Q16566
CREBBP
[Q92793
re946
20842175 

Calcium Signalling
cytosol
nucleus
CREB1
[P16220
NSMF
[] 
CREB1
[P16220
re947
20842175 

Calcium Signalling
cytosol
nucleus
NELF:importin alpha
[] 
 NELF:importin alpha
[] 
re958
20842175 

Calcium Signalling
cytosol
nucleus
NSMF
[],
Importin subunit alpha
[] 
 NELF:importin alpha
[] 
re959
20842175 

Calcium Signalling
cytosol
NSMF
[],
CABP1
[Q9NZU7
 NELF:caldendrin
[] 
re960
20842175 

17565599 

Calcium Signalling
cytosol
nucleus
CREB1
[P16220],
CRTC1
[Q6UUV9
 CREB:TORC1
[P16220, Q6UUV9
re961
20842175 

17565599 

Calcium Signalling
cytosol
nucleus
CREB1
[P16220],
CRTC2
[Q53ET0
 CREB:TORC2
[P16220, Q53ET0
re962
20842175 

Calcium Signalling
cytosol
nucleus
CREB:CBP
[Q92793, P16220
 CREB dependent transcription
[] 
re963
20842175 

Calcium Signalling
cytosol
nucleus
CREB:TORC2
[P16220, Q53ET0
 CREB dependent transcription
[] 
re964
20842175 

Calcium Signalling
cytosol
nucleus
CREB:TORC1
[P16220, Q6UUV9
 CREB dependent transcription
[] 
re970
10089876 

Calcium Signalling
cytosol
Ca2+
[CHEBI:29108
 Calcinuerin
[P16298, P48454, Q08209, Q96LZ3, P63098
re971
20842175 

15454081 

Calcium Signalling
cytosol
CRTC2
[Q53ET0
Calcinuerin
[P16298, P48454, Q08209, Q96LZ3, P63098
CRTC2
[Q53ET0
re972
20842175 

15454081 

Calcium Signalling
cytosol
nucleus
CRTC2
[Q53ET0
cAMP
[CHEBI:17489],
Ca2+
[CHEBI:29108
CRTC2
[Q53ET0
re973
9697848 

Calcium Signalling
cytosol
Ca2+
[CHEBI:29108],
CALM1
[P62158
 Calmodulin
[P62158, CHEBI:29108
re975
17360587 

Calcium Signalling
cytosol
nucleus
CRTC1
[Q6UUV9
Ca2+
[CHEBI:29108],
cAMP
[CHEBI:17489
CRTC1
[Q6UUV9
re976
21157483 

Calcium Signalling
cytosol
ERK1 and ERK2 cascade
[] 
 TSC2
[P49815
re977
21619488 

mitochondrial outer membrane
Apoptosis
cytosol
HTRA2
[O43464
intrinsic apoptosis
[] 
HTRA2
[O43464
re979
21157483 

Calcium Signalling
cytosol
Akt pathway
[] 
 TSC2
[P49815
Reactions: 862