Reaction | Pubmed ids | Ontologies | Input | Modifier | Output |
re1067 | PINK1 / Parkin Pathway cytosol | SNCAIP [Q9Y6H5] | PARK2 [O60260] | SNCAIP [Q9Y6H5] | |
re1069 | PINK1 / Parkin Pathway cytosol | Alpha tubulin [] | PARK2 [O60260] | Alpha tubulin [] | |
re1070 | PINK1 / Parkin Pathway cytosol | SEPT5 [Q99719] | PARK2 [O60260] | SEPT5 [Q99719] | |
re1072 | PINK1 / Parkin Pathway cytosol | GPR37 [O15354] | PARK2 [O60260] | GPR37 [O15354] | |
re1073 | PINK1 / Parkin Pathway cytosol | SYT11 [Q9BT88] | PARK2 [O60260] | SYT11 [Q9BT88] | |
re1074 | PINK1 / Parkin Pathway cytosol | Beta tubulin [] | PARK2 [O60260] | Beta tubulin [] | |
re1075 | PINK1 / Parkin Pathway cytosol | cyclin E [P24864, O96020] | PARK2 [O60260] | cyclin E (ubiquitinated) [P24864, O96020] | |
re1076 | PINK1 / Parkin Pathway cytosol | RANBP2 [P49792] | PARK2 [O60260] | RANBP2 [P49792] | |
re1077 | PINK1 / Parkin Pathway cytosol | AIMP2 [Q13155] | PARK2 [O60260] | AIMP2 [Q13155] | |
re1078 | PINK1 / Parkin Pathway cytosol | FUBP1 [Q96AE4] | PARK2 [O60260] | FUBP1 [Q96AE4] | |
re1079 | PINK1 / Parkin Pathway cytosol | SIM2 [Q14190] | PARK2 [O60260] | SIM2 [Q14190] | |
re1080 | PINK1 / Parkin Pathway cytosol | SLC6A3 [Q01959] | PARK2 [O60260] | SLC6A3 [Q01959] | |
re1081 | PINK1 / Parkin Pathway cytosol | SNCA [P37840] | PARK2 [O60260] | SNCA [P37840] | |
re1082 | Calcium Signalling cytosol | ATG1 kinase complex [O75143, Q8TDY2, Q9BSB4, O75385] | AMPK [Q9Y478, Q9UGJ0, P54646, Q9UGI9, O43741, P54619, Q13131] | ULK1 complex [O75143, Q8TDY2, Q9BSB4, O75385] | |
re1083 | mitochondrial outer membrane PINK1 / Parkin Pathway mitochondrial inner membrane cytosol | DNM1L [O00429] | mitochondrial fission [] | ||
re1084 | mitochondrial outer membrane PINK1 / Parkin Pathway mitochondrial inner membrane cytosol | OPA1 [O60313] | mitochondrial fusion [] | ||
re1085 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | DNM1L [O00429] | cAMP/cGMP-dependent protein kinase [] | DNM1L [O00429] | |
re1087 | mitochondrial outer membrane PINK1 / Parkin Pathway mitochondrial inner membrane cytosol | MFN1 [Q8IWA4] | mitochondrial fusion [] | ||
re1088 | mitochondrial outer membrane PINK1 / Parkin Pathway mitochondrial inner membrane cytosol | MFN2 [O95140] | mitochondrial fusion [] | ||
re1091 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | DNM1L [O00429] | Calcinuerin [P16298, P48454, Q08209, Q96LZ3, P63098] | DNM1L [O00429] | |
re1092 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | DNM1L [O00429] | MUL1 [Q969V5] | DNM1L [O00429] | |
re1093 | mitochondrial outer membrane PINK1 / Parkin Pathway mitochondrial inner membrane cytosol | DNM1L [O00429] | mitochondrial fission [] | ||
re1095 | Calcium Signalling cytosol nucleus | NELF:importin alpha [] | NSMF [], Importin subunit alpha [] | ||
re1096 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | PINK1 [Q9BXM7] | TOM complex [Q96B49, O94826, O96008, Q9P0U1, Q15388, Q8N4H5, Q9NS69] | PINK1 [Q9BXM7] | |
re1097 | mitochondrial outer membrane PINK1 / Parkin Pathway mitochondrial inner membrane cytosol | PINK1 [Q9BXM7] | TIM Complex [O60830, O43615, Q99595, O14925, Q3ZCQ8], mitochondrial depolarization [] | PINK1 [Q9BXM7] | |
re1098 | mitochondrial outer membrane PINK1 / Parkin Pathway mitochondrial inner membrane cytosol | PINK1 [Q9BXM7] | PARL [Q9H300], PMPCA [Q10713], PMPCB [O75439] | s2004 [] | |
re1099 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | PINK1 [Q9BXM7] | PINK1 [Q9BXM7] | ||
re1100 | mitochondrial outer membrane Mitochondrial Electron Transport Chain cytosol | CCCP [] | mitochondrial depolarization [] | ||
re1102 | mitochondrial outer membrane PINK1 / Parkin Pathway mitochondrial inner membrane cytosol | mitochondrial depolarization [] | mitochondrial fission [] | ||
re1103 | mitochondrial outer membrane PINK1 / Parkin Pathway mitochondrial inner membrane cytosol | mitochondrial depolarization [] | mitochondrial fusion [] | ||
re1104 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | MFN1 [Q8IWA4] | PINK1:PARK2 [O60260, Q9BXM7] | MFN1 [Q8IWA4] | |
re1105 | PINK1 / Parkin Pathway cytosol | DNM1L [O00429] | PARK2 [O60260] | DNM1L [O00429] | |
re1106 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | MFN2 [O95140] | PINK1:PARK2 [O60260, Q9BXM7] | MFN2 [O95140] | |
re114 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | ADP [CHEBI:16761], H+ [CHEBI:15378] | F0F1-ATP synthase (complex V) [P36542, P48201, P25705, O75947, P30049, Q06055, P56385, O75964, P00846, P48047, Q9UII2, Q7Z4Y8, P05496, P06576, Q5VTU8, P56381, P03928, P18859, P56134, P24539] | ATP [CHEBI:15422], H+ [CHEBI:15378] | |
re116 | Calcium Signalling cytosol | Ca2+ [CHEBI:29108] | CACNA1D [Q01668] | Ca2+ [CHEBI:29108] | |
re1198 | cytosol | O2 [CHEBI:15379] | superoxide [CHEBI:18421] | ||
re1199 | ROS Metabolism cytosol | superoxide [CHEBI:18421], H+ [CHEBI:15378] | SOD1 [P00441] | hydrogen peroxide [CHEBI:16240] | |
re120 | mitochondrial outer membrane mitochondrial inner membrane cytosol | Ca2+ [CHEBI:29108] | ROS [CHEBI:26523] | ||
re1200 | ROS Metabolism cytosol | hydrogen peroxide [CHEBI:16240] | CAT [P04040] | H2O [CHEBI:15377], O2 [CHEBI:15379] | |
re1201 | ROS Metabolism cytosol | hydrogen peroxide [CHEBI:16240], TXN [P10599] | PRDX1 [Q06830], PRDX2 [P32119], PRDX5 [P30044], PRDX6 [P30041] | H2O [CHEBI:15377], TXN [P10599] | |
re1202 | ROS Metabolism cytosol | TXN [P10599], NADPH [CHEBI:16474] | TXNRD2 [Q9NNW7], TXNRD1 [Q16881] | TXN [P10599], NADP(+) [CHEBI:18009] | |
re1203 | ROS Metabolism cytosol | hydrogen peroxide [CHEBI:16240], glutathione [CHEBI:16856] | GPX1 [P07203], GPX4 [P36969] | H2O [CHEBI:15377], glutathione disulfide [CHEBI:17858] | |
re1204 | ROS Metabolism cytosol | glutathione disulfide [CHEBI:17858], NADPH [CHEBI:16474] | GSR [P00390] | glutathione [CHEBI:16856], NADP(+) [CHEBI:18009] | |
re1205 | cytosol | superoxide [CHEBI:18421] | ROS [CHEBI:26523] | ||
re1206 | ROS Metabolism cytosol | hydrogen peroxide [CHEBI:16240] | ROS [CHEBI:26523] | ||
re1207 | ROS Metabolism cytosol | hydrogen peroxide [CHEBI:16240], Fe2+ [] | hydroxide [CHEBI:16234], Fe3+ [], hydroxyl [CHEBI:29191] | ||
re1208 | ROS Metabolism cytosol | hydroxyl [CHEBI:29191] | ROS [CHEBI:26523] | ||
re1209 | ROS Metabolism cytosol | hydroxyl [CHEBI:29191], Fe2+ [] | hydroxide [CHEBI:16234], Fe3+ [] | ||
re1210 | ROS Metabolism cytosol | hydrogen peroxide [CHEBI:16240], hydroxyl [CHEBI:29191] | superoxide [CHEBI:18421], H2O [CHEBI:15377], H+ [CHEBI:15378] | ||
re1211 | ROS Metabolism cytosol | superoxide [CHEBI:18421], Fe3+ [] | O2 [CHEBI:15379], Fe2+ [], H+ [CHEBI:15378] | ||
re1212 | ROS Metabolism cytosol | hydrogen peroxide [CHEBI:16240] | ROS [CHEBI:26523] | ||
re1213 | ROS Metabolism cytosol | superoxide [CHEBI:18421] | ROS [CHEBI:26523] | ||
re1214 | mitochondrial outer membrane mitochondrial inner membrane Fatty Acid / Ketone Body Metabolism cytosol | ACADL [P28330] | SIRT3 [Q9NTG7] | ACADL [P28330] | |
re1215 | mitochondrial outer membrane mitochondrial inner membrane Fatty Acid / Ketone Body Metabolism cytosol | ACADL [P28330] | SIRT3 [Q9NTG7] | ACADL [P28330] | |
re1217 | Inflammation Signalling / Apoptosis cytosol | IKK complex [O15111, Q9Y6K9, O14920] | MAP3K7 [O43318], ROS [CHEBI:26523] | IKK complex [O15111, Q9Y6K9, O14920] | |
re1218 | Inflammation Signalling / Apoptosis cytosol | NFKBIA [P25963] | UPS [] | s2522 [] | |
re1220 | Inflammation Signalling / Apoptosis cytosol | NF- kappa B:I kappa B [P25963, P19838, Q04206] | IKK complex [O15111, Q9Y6K9, O14920] | NF-kappa B:I kappa B [P25963, P19838, Q04206] | |
re1221 | Inflammation Signalling / Apoptosis cytosol | NF-kappa B:I kappa B [P25963, P19838, Q04206] | NF-kappa B [P19838, Q04206], NFKBIA [P25963] | ||
re1224 | Inflammation Signalling / Apoptosis cytosol | NF-kappa B:I kappa B [P25963, P19838, Q04206] | BTRC [Q9Y297] | NF-kappa B:I kappa B [P25963, P19838, Q04206] | |
re1225 | Inflammation Signalling / Apoptosis cytosol | NFKB1 [P19838], RELA [Q04206], NFKBIA [P25963] | NF- kappa B:I kappa B [P25963, P19838, Q04206] | ||
re1227 | cytosol | IL1 receptor [P27930, P14778] | IL1B [P01584] | IL1 receptor [P27930, P14778] | |
re1228 | cytosol | TNFRSF1A [P19438] | TNF [P01375] | TNFRSF1A [P19438] | |
re1230 | Inflammation Signalling / Apoptosis cytosol | TNFRSF1A [P19438] | MAP3K7 [O43318] | ||
re1231 | microglia Microglia | TNF [P01375] | TNF [P01375] | ||
re1232 | Astrocyte astrocyte | TNF [P01375] | TNF [P01375] | ||
re1233 | microglia Microglia | IL1B [P01584] | IL1B [P01584] | ||
re1234 | Astrocyte astrocyte | IL1B [P01584] | IL1B [P01584] | ||
re1235 | microglia Microglia | NADPH oxidase complex [P04839, P14598, Q9HBY0] | superoxide [CHEBI:18421] | ||
re1236 | Astrocyte astrocyte | NADPH oxidase complex [P04839, P14598, Q9HBY0] | ROS [CHEBI:26523] | ||
re1239 | Inflammation Signalling / Apoptosis cytosol | ROS [CHEBI:26523] | ROS [CHEBI:26523] | ||
re1242 | microglia Microglia | PTGS2 [P35354] | prostaglandin E2 [CHEBI:15551] | ||
re1243 | microglia Microglia | prostaglandin E2 [CHEBI:15551] | prostaglandin E2 [CHEBI:15551] | ||
re1244 | microglia Microglia | IL6 [P05231] | IL6 [P05231] | ||
re1245 | Astrocyte astrocyte | FASLG [P48023] | FASLG [P48023] | ||
re1246 | mitochondrial outer membrane Apoptosis cytosol | HTRA2 [O43464] | HAX1:PARL [Q9H300, O00165] | HTRA2 [O43464] | |
re1250 | Alpha-synuclein / Lewy Bodies Lewy body cytosol | misfolded [P37840] | misfolded [P37840] | ||
re1251 | Alpha-synuclein / Lewy Bodies Lewy body cytosol | protofibril [P37840] | protofibril [P37840] | ||
re1252 | Alpha-synuclein / Lewy Bodies lysosome cytosol | lysosome organization [] | lysosome [] | ||
re1253 | Alpha-synuclein / Lewy Bodies cytosol | rapamycin [] | lysosome organization [] | ||
re1254 | Alpha-synuclein / Lewy Bodies Lewy body lysosome autolysosome cytosol | lysosome [], Lewy Body [] | Autolysosome [] | ||
re1255 | Alpha-synuclein / Lewy Bodies autolysosome cytosol | Autolysosome [] | s2132 [] | ||
re1258 | Alpha-synuclein / Lewy Bodies cytosol | SNCA [P37840] | UPS [] | s2133 [] | |
re1259 | microglia Microglia | NOS2 [P35228] | NO [CHEBI:16480] | ||
re1260 | Astrocyte astrocyte | NOS2 [P35228] | NO [CHEBI:16480] | ||
re1261 | microglia Microglia | NO [CHEBI:16480] | NO [CHEBI:16480] | ||
re1262 | Astrocyte astrocyte | NO [CHEBI:16480] | NO [CHEBI:16480] | ||
re1269 | Microtubules MAPT/Tau Phosphorylation cytosol | MAPT [P10636] | MPTP [], activated LRRK2 [Q5S007], MAPK8 [P45983], MAPK11 [Q15759], MAPK12 [P53778], MAPK13 [O15264], MAPK14 [Q16539], GSK3B [P49841] | MAPT [P10636] | |
re1270 | Microtubules MAPT/Tau Phosphorylation cytosol | MSN [P26038] | activated LRRK2 [Q5S007] | MSN [P26038] | |
re1271 | Microtubules MAPT/Tau Phosphorylation cytosol | EZR [P15311] | activated LRRK2 [Q5S007] | EZR [P15311] | |
re1272 | Microtubules MAPT/Tau Phosphorylation cytosol | RDX [P35241] | activated LRRK2 [Q5S007] | RDX [P35241] | |
re1273 | Microtubules MAPT/Tau Phosphorylation cytosol | Beta tubulin [] | activated LRRK2 [Q5S007] | Beta tubulin [] | |
re1274 | Microtubules MAPT/Tau Phosphorylation cytosol | TAOK3 [Q9H2K8] | activated LRRK2 [Q5S007] | TAOK3 [Q9H2K8] | |
re1275 | Microtubules MAPT/Tau Phosphorylation cytosol | STK3 [Q13188] | activated LRRK2 [Q5S007] | STK3 [Q13188] | |
re1276 | Microtubules MAPT/Tau Phosphorylation cytosol | STK24 [Q9Y6E0] | activated LRRK2 [Q5S007] | STK24 [Q9Y6E0] | |
re1277 | Microtubules MAPT/Tau Phosphorylation cytosol | STK25 [O00506] | activated LRRK2 [Q5S007] | STK25 [O00506] | |
re1278 | Microtubules MAPT/Tau Phosphorylation cytosol | LRRK2 [Q5S007] | PRKCZ [Q05513] | LRRK2 [Q5S007] | |
re1279 | Microtubules MAPT/Tau Phosphorylation cytosol | EIF4EBP1 [Q13541] | activated LRRK2 [Q5S007] | EIF4EBP1 [Q13541] | |
re1280 | Microtubules MAPT/Tau Phosphorylation cytosol | FOXO1 [Q12778] | activated LRRK2 [Q5S007] | FOXO1 [Q12778] | |
re1284 | Dopamine Secretion / Recycling cytosol | misfolded [P60880] | misfolded [P60880] | ||
re1285 | Dopamine Secretion / Recycling cytosol | misfolded [P60880] | UPS [] | s2242 [] | |
re1287 | Alpha-synuclein / Lewy Bodies cytosol | protofibril [P37840] | dopamine [CHEBI:18243], L-dopa [CHEBI:15765], geldanamycin [] | fibril [P37840] | |
re1288 | Alpha-synuclein / Lewy Bodies Lewy body cytosol | fibril [P37840] | fibril [P37840] | ||
re1292 | Inflammation Signalling / Apoptosis Apoptosis nucleus cytosol | PTGS2 [] | NF-kB [P19838, Q04206], MAPK9 [P45984], MAPK10 [P53779] | PTGS2 [] | |
re1297 | Fatty Acid / Ketone Body Metabolism cytosol | prostaglandin H2 [CHEBI:15554] | PTGES2 [Q9H7Z7], PTGES [O14684], PTGES3 [Q15185] | prostaglandin E2 [CHEBI:15551] | |
re1298 | Fatty Acid / Ketone Body Metabolism cytosol | prostaglandin H2 [CHEBI:15554] | PTGDS [P41222], UPS [] | prostaglandin D2 [CHEBI:15555] | |
re1299 | Fatty Acid / Ketone Body Metabolism cytosol | prostaglandin H2 [CHEBI:15554] | AKR1C3 [P42330] | prostaglandin F2 alpha [CHEBI:15553] | |
re1301 | Dopamine Secretion / Recycling cytosol fusing synaptic vesicle | SNCA [P37840] | arachidonic acid [CHEBI:15843] | ||
re1302 | Dopamine Secretion / Recycling cytosol | SNCA [P37840] | arachidonic acid [CHEBI:15843] | ||
re1303 | Alpha-synuclein / Lewy Bodies cytosol | SNCA [P37840] | fibril [P37840] | ||
re1304 | Alpha-synuclein / Lewy Bodies cytosol | SNCA [P37840] | fibril [P37840] | ||
re1305 | Alpha-synuclein spreading cytosol | protofibril [P37840] | protofibril [P37840] | ||
re1306 | Alpha-synuclein spreading cytosol | Ca2+ [CHEBI:29108] | protofibril [P37840], ionomycin [], BAPTA [] | Ca2+ [CHEBI:29108] | |
re1307 | microglia Microglia | extracellular alpha synuclein [P37840] | phagocytosis [] | alpha synuclein [P37840] | |
re1308 | microglia Microglia | alpha synuclein [P37840] | ROS [CHEBI:26523] | oxidized alpha synuclein [P37840] | |
re1309 | microglia Microglia | alpha synuclein [P37840] | NO [CHEBI:16480], peroxynitrite [CHEBI:25941] | nitrated alpha synuclein [P37840] | |
re1310 | microglia Microglia | oxidized alpha synuclein [P37840] | microglia activation [] | ||
re1311 | microglia Microglia | nitrated alpha synuclein [P37840] | microglia activation [] | ||
re1312 | Astrocyte astrocyte | ROS [CHEBI:26523] | ROS [CHEBI:26523] | ||
re1313 | microglia Microglia | ROS [CHEBI:26523] | ROS [CHEBI:26523] | ||
re1314 | microglia Microglia | microglia activation [] | NOS2 [P35228] | ||
re1315 | microglia Microglia | microglia activation [] | ROS [CHEBI:26523] | ||
re1316 | microglia Microglia | microglia activation [] | PTGS2 [P35354] | ||
re1317 | microglia Microglia | microglia activation [] | TNF [P01375] | ||
re1318 | microglia Microglia | Glucocorticoid:NR3C1 [P04150, CHEBI:24261] | microglia activation [] | ||
re1319 | microglia Microglia | glucocorticoid [CHEBI:24261] | glucocorticoid [CHEBI:24261] | ||
re1320 | microglia Microglia | glucocorticoid [CHEBI:24261], NR3C1 [P04150] | Glucocorticoid:NR3C1 [P04150, CHEBI:24261] | ||
re1324 | microglia Microglia | cell surface PRR signaling pathway [] | TLR2 [O60603] | ||
re1325 | microglia Microglia | cell surface PRR signaling pathway [] | TLR3 [O15455] | ||
re1326 | microglia Microglia | cell surface PRR signaling pathway [] | TLR4 [O00206] | ||
re1327 | microglia Microglia | TLR2 [O60603] | NIK/NF-kappaB cascade [] | ||
re1328 | microglia Microglia | TLR3 [O15455] | NIK/NF-kappaB cascade [] | ||
re1329 | microglia Microglia | TLR4 [O00206] | NIK/NF-kappaB cascade [] | ||
re1330 | mitochondrial outer membrane PINK1 / Parkin Pathway mitochondrial inner membrane cytosol | Mitochondrial permeability transition pore (close) [P21796, P12235, P30405] | ROS [CHEBI:26523], mitochondrial depolarization [], ATP [CHEBI:15422] | Mitochondrial permeability transition pore (open) [P21796, P12235, P30405] | |
re1331 | mitochondrial outer membrane mitochondrial inner membrane cytosol | Ca2+ [CHEBI:29108] | Mitochondrial permeability transition pore (open) [P21796, P12235, P30405] | Ca2+ [CHEBI:29108] | |
re1332 | Dopamine Secretion / Recycling dopamine-loaded synaptic vesicle acidified vesicle cytosol | acidified vesicle [] | LRRK2 [Q5S007] | dopamine-loaded synaptic vesicle [] | |
re1333 | Dopamine Secretion / Recycling docked dynaptic vesicle cytosol fusing synaptic vesicle | docked synaptic vesicle [] | fusing synaptic vesicle [] | ||
re1334 | Dopamine Secretion / Recycling docked dynaptic vesicle cytosol fusing synaptic vesicle | fusing synaptic vesicle [] | docked synaptic vesicle [] | ||
re1335 | Dopamine Secretion / Recycling dopamine-loaded synaptic vesicle docked dynaptic vesicle cytosol | Syntaxin:Munc18 [P61764, Q16623], SNAP25 [P60880], VAMP2 [P63027] | CSP:Hsc70:SGT [P11142, O43765, Q9H3Z4], SNCA [P37840], Calcium channel:RIMBP:RIM:MUNC13:RAB [], CPLX1 [O14810] | trans-SNARE complex [P61764, P63027, Q16623, P60880] | |
re1336 | Dopamine Secretion / Recycling cytosol | SNAP25 [P60880] | misfolded [P60880] | ||
re1337 | Dopamine Secretion / Recycling acidified vesicle cytosol | H+ [CHEBI:15378], ATP [CHEBI:15422] | V-ATPase [] | H+ [CHEBI:15378], ADP [CHEBI:16761] | |
re1338 | Dopamine Secretion / Recycling cytosol | cis-SNARE complex [P61764, P63027, Q16623, P60880] | NSF:NAPA [P46459, O96009], NSF:NAPB [P46459, Q9H115] | Syntaxin:Munc18 [P61764, Q16623], SNAP25 [P60880], VAMP2 [P63027] | |
re1339 | Dopamine Secretion / Recycling cytosol | UNC13B [O14795] | Ca2+ [CHEBI:29108] | UNC13B [O14795] | |
re1340 | Dopamine Secretion / Recycling cytosol | UNC13B [O14795], RIMS1 [Q86UR5] | RIMS:Munc13 [Q86UR5, O14795] | ||
re1341 | Dopamine Secretion / Recycling cytosol | Ca2+ [CHEBI:29108] | Ca channel:RIMBP [] | Ca2+ [CHEBI:29108] | |
re1342 | Dopamine Secretion / Recycling dopamine-loaded synaptic vesicle docked dynaptic vesicle cytosol | Ca channel:RIMBP [], RIMS:Munc13 [Q86UR5, O14795], RAB3A [P20336] | Calcium channel:RIMBP:RIM:MUNC13:RAB [] | ||
re1343 | Dopamine Secretion / Recycling cytosol fusing synaptic vesicle | trans-SNARE complex [P61764, P63027, Q16623, P60880] | cis-SNARE complex [P61764, P63027, Q16623, P60880] | ||
re1345 | Dopamine Secretion / Recycling acidified vesicle cytosol fusing synaptic vesicle | fusing synaptic vesicle [] | LRRK2 [Q5S007] | acidified vesicle [] | |
re1347 | Dopamine Secretion / Recycling acidified vesicle early endosome cytosol | acidified vesicle [] | early endosome [] | ||
re1348 | Dopamine Secretion / Recycling dopamine-loaded synaptic vesicle early endosome cytosol | early endosome [] | dopamine-loaded synaptic vesicle [] | ||
re1350 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | PINK1:PARK2 [O60260, Q9BXM7] | mitophagy [] | ||
re1351 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | RHOT1 [Q8IXI2] | PINK1:PARK2 [O60260, Q9BXM7] | RHOT1 [Q8IXI2] | |
re1352 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | RHOT2 [Q8IXI1] | PINK1:PARK2 [O60260, Q9BXM7] | RHOT2 [Q8IXI1] | |
re1353 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | RHOT1 [Q8IXI2], TRAK1 [Q9UPV9] | Miro-1:Milton:Kinesin-1 heavy chain [Q9UPV9, P33176, Q8IXI2], KIF5B [P33176] | ||
re1354 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | RHOT2 [Q8IXI1], TRAK1 [Q9UPV9] | Miro-2:Milton:Kinesin-1 heavy chain [Q9UPV9, Q8IXI1, P33176], KIF5B [P33176] | ||
re1355 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | Miro-1:Milton:Kinesin-1 heavy chain [Q9UPV9, P33176, Q8IXI2] | mitochondrial motility [] | ||
re1356 | mitochondrial outer membrane cytosol | Miro-2:Milton:Kinesin-1 heavy chain [Q9UPV9, Q8IXI1, P33176] | mitochondrial motility [] | ||
re1357 | PINK1 / Parkin Pathway cytosol | RHOT1 [Q8IXI2] | UPS [] | s2309 [] | |
re1358 | PINK1 / Parkin Pathway cytosol | RHOT2 [Q8IXI1] | UPS [] | s2309 [] | |
re1359 | PINK1 / Parkin Pathway cytosol | MFN1 [Q8IWA4] | UPS [] | s2310 [] | |
re1360 | PINK1 / Parkin Pathway cytosol | MFN2 [O95140] | UPS [] | s2310 [] | |
re1361 | mitochondrial outer membrane Apoptosis cytosol | ROS [CHEBI:26523] | PINK1 [Q9BXM7] | ||
re1362 | mitochondrial outer membrane Apoptosis cytosol | TRAP1 [Q12931] | PINK1 [Q9BXM7] | TRAP1 [Q12931] | |
re1363 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | SNCA [P37840] | ROS [CHEBI:26523] | ||
re1364 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | SNCA [P37840] | TOM complex [Q96B49, O94826, O96008, Q9P0U1, Q15388, Q8N4H5, Q9NS69] | SNCA [P37840] | |
re1365 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | TOM complex [Q96B49, O94826, O96008, Q9P0U1, Q15388, Q8N4H5, Q9NS69] | PINK1:PARK2 [O60260, Q9BXM7] | TOM complex [Q96B49, O94826, O96008, Q9P0U1, Q15388, Q8N4H5, Q9NS69] | |
re1367 | mitochondrial outer membrane Apoptosis cytosol | HTRA2 [O43464] | MAPK12 [P53778], PINK1 [Q9BXM7], MAPK14 [Q16539] | HTRA2 [O43464] | |
re1368 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | SNCA [P37840] | ROS [CHEBI:26523] | ||
re1371 | mitochondrial outer membrane PINK1 / Parkin Pathway mitochondrial inner membrane cytosol | SNCA [P37840] | mitochondrial fission [] | ||
re1372 | mitochondrial outer membrane PINK1 / Parkin Pathway mitochondrial inner membrane cytosol | SNCA [P37840] | mitophagy [] | ||
re1374 | mitochondrial outer membrane PINK1 / Parkin Pathway mitochondrial inner membrane cytosol | SNCA [P37840] | mitochondrial fission [] | ||
re1375 | mitochondrial outer membrane PINK1 / Parkin Pathway mitochondrial inner membrane cytosol | SNCA [P37840] | mitochondrial fission [] | ||
re1376 | mitochondrial outer membrane PINK1 / Parkin Pathway mitochondrial inner membrane cytosol | protofibril [P37840] | mitochondrial fission [] | ||
re1379 | multivesicular body Alpha-synuclein spreading exosome cytosol | multivesicular body [] | Ca2+ [CHEBI:29108], thapsigargin [], methylamine [], ionomycin [], BAPTA [] | exosome [] | |
re1380 | Alpha-synuclein spreading exosome | exosome [] | SNCA [P37840], protofibril [P37840], GAPDH [P04406], PDCD6IP [Q8WUM4], ANXA2 [P07355], flotillin [Q14254, O75955], HSP70 [Q9Y4L1] | ||
re1381 | multivesicular body late endosome Alpha-synuclein spreading cytosol | late endosome [] | multivesicular body [] | ||
re1382 | Dopamine Secretion / Recycling late endosome early endosome cytosol | early endosome [] | RAB5A [P20339] | late endosome [] | |
re1383 | Dopamine Metabolism cytosol | dopamine [CHEBI:18243] | TYR [P14679] | dopaminoquinone [CHEBI:74684] | |
re1385 | Dopamine Metabolism cytosol | dopaminoquinone [CHEBI:74684] | SOD1 [P00441] | dopamine [CHEBI:18243] | |
re1386 | Dopamine Metabolism cytosol | L-dopa [CHEBI:15765] | TYR [P14679] | L-dopaquinone [CHEBI:16852] | |
re1388 | Dopamine Metabolism cytosol | dopaminoquinone [CHEBI:74684], generic protein [] | Protein-dopamine adducts [] | ||
re1389 | Dopamine Metabolism cytosol | generic protein [], L-dopaquinone [CHEBI:16852] | Protein-dopa adducts [] | ||
re1390 | Dopamine Metabolism cytosol | dopaminoquinone [CHEBI:74684], SNCA [P37840] | SNCA [P37840] | ||
re1391 | Dopamine Metabolism cytosol | SNCA [P37840], L-dopaquinone [CHEBI:16852] | SNCA [P37840] | ||
re1392 | Dopamine Metabolism cytosol | dopaminoquinone [CHEBI:74684] | leukoaminochrome [CID 147311] | ||
re1393 | Dopamine Metabolism cytosol | L-dopaquinone [CHEBI:16852] | leucodopachrome [CHEBI:60872] | ||
re1394 | Dopamine Metabolism cytosol | leucodopachrome [CHEBI:60872] | L-dopachrome [CHEBI:15772] | ||
re1395 | Dopamine Metabolism cytosol | L-dopachrome [CHEBI:15772] | 5,6-dihydroxyindole [CHEBI:27404] | ||
re1396 | Dopamine Metabolism cytosol | leukoaminochrome [CID 147311] | indole-5,6-quinone [CHEBI:27406] | ||
re1397 | Dopamine Metabolism cytosol | 5,6-dihydroxyindole [CHEBI:27404] | indole-5,6-quinone [CHEBI:27406] | ||
re1398 | Dopamine Metabolism cytosol | L-dopachrome [CHEBI:15772] | 5,6-dihydroxyindole-2-carboxylic acid [CHEBI:2003] | ||
re1400 | Dopamine Metabolism cytosol | 5,6-dihydroxyindole [CHEBI:27404] | indole-5,6-quinone [CHEBI:27406] | ||
re1402 | Dopamine Metabolism cytosol | 5,6-dihydroxyindole-2-carboxylic acid [CHEBI:2003], indole-5,6-quinone [CHEBI:27406] | polymerization [] | neuromelanin [] | |
re1403 | Dopamine Metabolism cytosol | indole-5,6-quinone [CHEBI:27406] | NQO1 [P15559] | leukoaminochrome [CID 147311] | |
re1405 | microglia Microglia | alpha synuclein [P37840] | microglia activation [] | ||
re1407 | microglia Microglia cytosol | CX3CL1 [P78423] | CX3CR1 [P49238] | ||
re1409 | microglia Microglia | SIRPA [P78324] | microglia activation [] | ||
re1410 | microglia Microglia | CX3CR1 [P49238] | microglia activation [] | ||
re1411 | microglia Microglia | CD200R1 [Q8TD46] | microglia activation [] | ||
re1413 | microglia Microglia | NXPH1:PLXNA1 [O14786, Q9UIW2] | apoptosis [] | ||
re1414 | microglia Microglia | apoptosis [] | microglia activation [] | ||
re1415 | microglia Microglia | microglia activation [] | PLXNA1 [Q9UIW2] | ||
re1416 | microglia Microglia | microglia activation [] | NRP1 [O14786] | ||
re1418 | microglia Microglia | SEMA3A [Q14563] | NXPH1:PLXNA1 [O14786, Q9UIW2] | ||
re1419 | cytosol | SEMA3A [Q14563] | SEMA3A [Q14563] | ||
re1420 | microglia Microglia | NRP1 [O14786], PLXNA1 [Q9UIW2] | NXPH1:PLXNA1 [O14786, Q9UIW2] | ||
re1421 | microglia Microglia | microglia activation [] | NADPH oxidase complex [P04839, P14598, Q9HBY0] | ||
re1422 | microglia Microglia | IFNG [P01579] | IFNGR1:IFNGR2:JAK1:JAK2 [P23458, P15260, O60674, P38484] | ||
re1423 | microglia Microglia | IFNGR1:IFNGR2:JAK1:JAK2 [P23458, P15260, O60674, P38484] | microglia activation [] | ||
re1424 | microglia Microglia cytosol | CD22 [P20273] | PTPRC [P08575] | ||
re1425 | microglia Microglia | PTPRC [P08575] | microglia activation [] | ||
re1426 | microglia Microglia | LPS [CHEBI:16412] | TLR4 [O00206] | ||
re1427 | microglia Microglia | TLR2 [O60603] | MAPK cascade [] | ||
re1428 | microglia Microglia | TLR3 [O15455] | MAPK cascade [] | ||
re1429 | microglia Microglia | TLR4 [O00206] | MAPK cascade [] | ||
re1430 | microglia Microglia | NIK/NF-kappaB cascade [] | microglia activation [] | ||
re1432 | microglia Microglia | neuromelanin [] | NIK/NF-kappaB cascade [] | ||
re1433 | microglia Microglia | neuromelanin [] | MAPK cascade [] | ||
re1434 | cytosol | neuromelanin [] | neuron death [] | neuromelanin [] | |
re1436 | Fatty Acid / Ketone Body Metabolism cytosol | peroxide [CHEBI:44785] | ROS [CHEBI:26523] | ||
re1437 | Calcium Signalling cytosol nucleus | ATXN3 [P54252] | CREB:CBP [Q92793, P16220] | ||
re1438 | Calcium Signalling cytosol nucleus | ATXN3 [P54252] | ROS [CHEBI:26523] | ATXN3 [P54252] | |
re1439 | late endosome cytosol | RAB7A [P51149] | TBC1D5 [Q92609] | RAB7A [P51149] | |
re1441 | late endosome cytosol | VPS29:VPS26:VPS29 [Q96QK1, Q4G0F5, O75436, Q9UBQ0], RAB7A [P51149] | VPS29:VPS26:VPS29:RAB7A [P51149, Q96QK1, Q4G0F5, O75436, Q9UBQ0] | ||
re1442 | late endosome cytosol | VPS29:VPS26:VPS29:RAB7A [P51149, Q96QK1, Q4G0F5, O75436, Q9UBQ0], SNX1:SNX2:SNX5:SNX6:SNX32 [O60749, Q9Y5X3, Q9UNH7, Q13596, Q86XE0] | VPS29:VPS26:VPS29:RAB7A:SNX1:SNX2:SNX5:SNX6:SNX32 [P51149, Q96QK1, O60749, Q4G0F5, Q9Y5X3, Q9UNH7, O75436, Q13596, Q9UBQ0, Q86XE0] | ||
re1443 | late endosome trans-Golgi network cytosol | late endosome [] | retrograde transport, endosome to Golgi [] | trans-Golgi network [] | |
re1444 | late endosome cytosol | VPS29:VPS26:VPS29:RAB7A:SNX1:SNX2:SNX5:SNX6:SNX32 [P51149, Q96QK1, O60749, Q4G0F5, Q9Y5X3, Q9UNH7, O75436, Q13596, Q9UBQ0, Q86XE0] | retrograde transport, endosome to Golgi [] | ||
re1445 | Dopamine Secretion / Recycling early endosome cytosol | RAB7A [P51149] | TBC1D5 [Q92609] | RAB7A [P51149] | |
re1446 | Dopamine Secretion / Recycling early endosome cytosol | RAB7A [P51149] | RAB7A [P51149] | ||
re1447 | Dopamine Secretion / Recycling early endosome cytosol | VPS29:VPS26:VPS35 [Q96QK1, Q4G0F5, O75436, Q9UBQ0], RAB7A [P51149] | VPS29:VPS26:VPS35:RAB7A [P51149, Q96QK1, Q4G0F5, O75436, Q9UBQ0] | ||
re1448 | Dopamine Secretion / Recycling early endosome cytosol | VPS29:VPS26:VPS35:RAB7A [P51149, Q96QK1, Q4G0F5, O75436, Q9UBQ0], SNX1:SNX2:SNX5:SNX6:SNX32 [O60749, Q9Y5X3, Q9UNH7, Q13596, Q86XE0] | VPS29:VPS26:VPS29:RAB7A:SNX1:SNX2:SNX5:SNX6:SNX32 [P51149, Q96QK1, O60749, Q4G0F5, Q9Y5X3, Q9UNH7, O75436, Q13596, Q9UBQ0, Q86XE0] | ||
re1449 | Dopamine Secretion / Recycling early endosome cytosol | VPS29:VPS26:VPS29:RAB7A:SNX1:SNX2:SNX5:SNX6:SNX32 [P51149, Q96QK1, O60749, Q4G0F5, Q9Y5X3, Q9UNH7, O75436, Q13596, Q9UBQ0, Q86XE0] | retrograde transport, endosome to Golgi [] | ||
re1450 | Dopamine Secretion / Recycling early endosome trans-Golgi network cytosol | early endosome [] | retrograde transport, endosome to Golgi [] | trans-Golgi network [] | |
re1451 | Dopamine Secretion / Recycling early endosome cytosol | VPS29:VPS26:VPS35 [Q96QK1, Q4G0F5, O75436, Q9UBQ0], SNX3:SNX12 [O60493, Q9UMY4] | VPS29:VPS26A:VPS26B:VPS35:SNX3:SNX12 [Q96QK1, Q4G0F5, O60493, O75436, Q9UMY4, Q9UBQ0] | ||
re1452 | mitochondrial outer membrane peroxisome cytosol | VPS26:VPS35:MUL1 [Q96QK1, Q4G0F5, O75436, Q969V5] | VPS26:VPS35:MUL1 [Q96QK1, Q4G0F5, O75436, Q969V5] | ||
re1453 | Alpha-synuclein / Lewy Bodies endolysosome lysosome late endosome cytosol | late endosome [], lysosome [] | RAB7A [P51149] | endolysosome [] | |
re1454 | Dopamine Secretion / Recycling early endosome cytosol | VPS29:VPS26A:VPS26B:VPS35:SNX3:SNX12 [Q96QK1, Q4G0F5, O60493, O75436, Q9UMY4, Q9UBQ0] | retrograde transport, endosome to Golgi [] | ||
re1471 | PINK1 / Parkin Pathway cytosol | Alpha tubulin [] | UPS [] | s2404 [] | |
re1472 | PINK1 / Parkin Pathway cytosol | GPR37 [O15354] | UPS [] | s2404 [] | |
re1473 | PINK1 / Parkin Pathway cytosol | SNCAIP [Q9Y6H5] | UPS [] | s2404 [] | |
re1474 | PINK1 / Parkin Pathway cytosol | cyclin E (ubiquitinated) [P24864, O96020] | UPS [] | s2404 [] | |
re1475 | PINK1 / Parkin Pathway cytosol | SYT11 [Q9BT88] | UPS [] | s2404 [] | |
re1476 | PINK1 / Parkin Pathway cytosol | SEPT5 [Q99719] | UPS [] | s2404 [] | |
re1477 | PINK1 / Parkin Pathway cytosol | FUBP1 [Q96AE4] | UPS [] | s2404 [] | |
re1478 | PINK1 / Parkin Pathway cytosol | AIMP2 [Q13155] | UPS [] | s2404 [] | |
re1479 | PINK1 / Parkin Pathway cytosol | RANBP2 [P49792] | UPS [] | s2404 [] | |
re1480 | PINK1 / Parkin Pathway cytosol | SNCA [P37840] | UPS [] | s2404 [] | |
re1481 | PINK1 / Parkin Pathway cytosol | SLC6A3 [Q01959] | UPS [] | s2404 [] | |
re1482 | PINK1 / Parkin Pathway cytosol | SIM2 [Q14190] | UPS [] | s2404 [] | |
re1485 | ROS-dependent NFE2L2 Signalling cytosol | KEAP1 [Q14145], PTMA [P06454] | KEAP1:PTMA [Q14145, P06454] | ||
re1486 | ROS-dependent NFE2L2 Signalling cytosol | KEAP1 [Q14145], PGAM5 [Q96HS1] | KEAP1:PGAM5 [Q96HS1, Q14145] | ||
re1553 | ROS-dependent NFE2L2 Signalling cytosol | NFE2L2 [Q16236] | KEAP1:CUL3 [Q13618, Q14145] | NFE2L2 [Q16236] | |
re1554 | ROS-dependent NFE2L2 Signalling cytosol | KEAP1:CUL3 [Q13618, Q14145] | ROS [CHEBI:26523] | KEAP1:CUL3 [Q13618, Q14145] | |
re1555 | ROS-dependent NFE2L2 Signalling cytosol nucleus | NFE2L2 [Q16236] | NFE2L2 [Q16236] | ||
re1556 | ROS-dependent NFE2L2 Signalling cytosol | NFE2L2 [Q16236] | Protein kinase C, alpha/beta/gamma types [], CSNK2A2 [P19784], MAPK1 [P28482], MAPK8 [P45983], EIF2AK3 [Q9NZJ5] | NFE2L2 [Q16236] | |
re1557 | Ubiquitin Proteasome System cytosol | proteasome:substrate complex [], ATP [CHEBI:15422] | protein unfolding [], proteasome:substrate complex [], SNCA [P37840], SNCA [P37840], protofibril [P37840], protein deubiquitination [] | a24_degraded [], phosphate ion [CHEBI:35780,CHEBI:18367], ubiquitin [P0CG48, P0CG47], ADP [CHEBI:16761] | |
re1558 | Ubiquitin Proteasome System cytosol | ubiquitin activating enzyme (E1) [P22314, A0AVT1], UBL-acyl adenylate intermediate [P0CG48, P0CG47, CHEBI:16027] | GSH/GSSG ratio [CHEBI:17858, CHEBI:16856] | E1:ubiquitin complex [P22314, A0AVT1, P0CG48, P0CG47, CHEBI:16027] | |
re1559 | Ubiquitin Proteasome System cytosol | E1:ubiquitin complex [P22314, A0AVT1, P0CG48, P0CG47, CHEBI:16027] | E1 [P22314, A0AVT1], AMP [CHEBI:16027] | ||
re1560 | Ubiquitin Proteasome System cytosol | Ubiquitin-conjugating enzyme, E2 [], E1:ubiquitin complex [P22314, A0AVT1, P0CG48, P0CG47, CHEBI:16027] | GSH/GSSG ratio [CHEBI:17858, CHEBI:16856] | E2:ubiquitin [], E1:ubiquitin complex [P22314, A0AVT1, P0CG48, P0CG47, CHEBI:16027] | |
re1561 | Ubiquitin Proteasome System cytosol | generic protein [], E2:ubiquitin [], ubiquitin-protein ligase (E3) [Q05086, O60260, Q15386] | E2:E3:substrate complex [] | ||
re1562 | Ubiquitin Proteasome System cytosol | generic protein [], ubiquitin [P0CG48, P0CG47] | ubiquitin-protein ligase (E3) [Q05086, O60260, Q15386], ubiquitin chain elongation factor (E4) [] | generic protein [] | |
re1564 | Ubiquitin Proteasome System cytosol | generic protein [] | endocytosis [] | ||
re1565 | cytosol | tetrodotoxin [] | SHANK2 [Q9UPX8] | ||
re1566 | cytosol | tetrodotoxin [] | GRIN2B [Q13224] | ||
re1568 | cytosol | tetrodotoxin [] | DLG4 [Q15334] | ||
re1569 | cytosol | tetrodotoxin [] | GRIN2A [Q12879] | ||
re1570 | cytosol | tetrodotoxin [] | CAMK2A [Q9UQM7] | ||
re1571 | cytosol | proteasome inhibitor [] | tetrodotoxin [] | ||
re1573 | Ubiquitin Proteasome System cytosol | E2:E3:substrate complex [] | generic protein [], Ubiquitin-conjugating enzyme, E2 [], ubiquitin-protein ligase (E3) [Q05086, O60260, Q15386] | ||
re1574 | cytosol | misfolded [Q99497] | PARK2 [O60260] | misfolded [Q99497] | |
re1575 | cytosol | misfolded [Q99497] | dynein [] | inclusion body [] | |
re1576 | cytosol | PARK2 [O60260] | LRRK2 [Q5S007], PARK2 [O60260] | PARK2 [O60260] | |
re1577 | Ubiquitin Proteasome System cytosol | ATXN3 [P54252] | type 3 spinocerebellar ataxia [] | ||
re1580 | Ubiquitin Proteasome System cytosol | VCP [P55072], UBE4B [O95155] | VCP:UBE4B [O95155, P55072] | ||
re1587 | Ubiquitin Proteasome System cytosol | VCP [P55072], ATXN3 [P54252] | ataxin 3:VCP [P54252, P55072] | ||
re1595 | Ubiquitin Proteasome System cytosol | misfolded [] | HSP70:chaperone [P25686, Q9UNE7, Q9Y4L1, Q99933] | generic protein [] | |
re1598 | cytosol | SHANK2 [Q9UPX8] | anchored proteasome [], pharmacological stimulation of synaptic activity [] | s1009 [] | |
re1599 | cytosol | DLG4 [Q15334] | anchored proteasome [], pharmacological stimulation of synaptic activity [] | s1010 [] | |
re1600 | cytosol | GRIP1 [Q9Y3R0] | anchored proteasome [], pharmacological stimulation of synaptic activity [] | s1007 [] | |
re1601 | Dopamine Secretion / Recycling cytosol | AKAP5 [P24588] | anchored proteasome [], pharmacological stimulation of synaptic activity [] | s1008 [] | |
re1602 | cytosol | PARK2 [O60260], HSP70 [Q9Y4L1] | PARK2:HSP70 [O60260, Q9Y4L1] | ||
re1606 | Ubiquitin Proteasome System cytosol | dexamethasone [] | ubiquitin [P0CG48, P0CG47] | ||
re1607 | Ubiquitin Proteasome System cytosol | dexamethasone [] | Ubiquitin-conjugating enzyme, E2 [] | ||
re1608 | Ubiquitin Proteasome System cytosol | dexamethasone [] | ubiquitin-protein ligase (E3) [Q05086, O60260, Q15386] | ||
re1609 | Ubiquitin Proteasome System cytosol | dexamethasone [] | 26S hybrid proteasome [Q15008, O00487, O00233, Q16186, P17980, P28070, P62191, O00231, O14818, P49720, P25788, P28074, Q99436, Q99460, P28066, P28072, P60900, P25787, P49721, P62195, P51665, O43242, P25786, P55036, P25789, P43686, O00232, P62333, P20618, P48556, P35998, Q13200] | ||
re1612 | Ubiquitin Proteasome System cytosol | E1 [P22314, A0AVT1], UBL-acyl adenylate intermediate [P0CG48, P0CG47, CHEBI:16027] | E1:ubiquitin complex [P22314, A0AVT1, P0CG48, P0CG47, CHEBI:16027] | ||
re1613 | Ubiquitin Proteasome System cytosol | E1 [P22314, A0AVT1], AMP [CHEBI:16027] | E1:ubiquitin complex [P22314, A0AVT1, P0CG48, P0CG47, CHEBI:16027] | ||
re1614 | Ubiquitin Proteasome System cytosol | E1:ubiquitin complex [P22314, A0AVT1, P0CG48, P0CG47, CHEBI:16027] | ubiquitin activating enzyme (E1) [P22314, A0AVT1], UBL-acyl adenylate intermediate [P0CG48, P0CG47, CHEBI:16027] | ||
re1615 | Ubiquitin Proteasome System cytosol | E1:ubiquitin complex [P22314, A0AVT1, P0CG48, P0CG47, CHEBI:16027] | E1 [P22314, A0AVT1], UBL-acyl adenylate intermediate [P0CG48, P0CG47, CHEBI:16027] | ||
re1617 | Ubiquitin Proteasome System cytosol | generic protein [] | protein deubiquitination [] | generic protein [] | |
re1618 | cytosol | UBE2L3 [P68036], PARK2 [O60260] | PARK2:UbcH7 [P68036, O60260] | ||
re1619 | Dopamine Metabolism cytosol | Tyrosine 3-monooxygenase (Fe2+ cofactor) [] | cAMP/cGMP-dependent protein kinase [] | Tyrosine 3-monooxygenase (Fe2+ cofactor) [] | |
re1620 | Alpha-synuclein / Lewy Bodies cytosol | SNCA [P37840] | ROS [CHEBI:26523], NO [CHEBI:16480] | misfolded [P37840] | |
re1621 | Dopamine Metabolism cytosol | DOPAL [CHEBI:27978] | ROS [CHEBI:26523] | ||
re1622 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | NDUFB3 [O43676] | NADH-Q oxireductase (complex I) [P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404] | ||
re1623 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | NDUFB5 [O43674] | NADH-Q oxireductase (complex I) [P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404] | ||
re1624 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | NDUFB6 [O95139] | NADH-Q oxireductase (complex I) [P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404] | ||
re1625 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | NDUFS3 [O75489] | NADH-Q oxireductase (complex I) [P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404] | ||
re1626 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | NDUFS5 [O43920] | NADH-Q oxireductase (complex I) [P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404] | ||
re1627 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | NDUFAB1 [O14561] | NADH-Q oxireductase (complex I) [P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404] | ||
re1628 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | NDUFC1 [O43677] | NADH-Q oxireductase (complex I) [P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404] | ||
re1629 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Glycolysis cytosol | SDHA [P31040] | Succinate dehydrogenase (complex II) [CHEBI:16238, CHEBI:30408, O14521, P21912, Q99643, P31040] | ||
re1630 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Glycolysis cytosol | SDHB [P21912] | Succinate dehydrogenase (complex II) [CHEBI:16238, CHEBI:30408, O14521, P21912, Q99643, P31040] | ||
re1631 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | UQCRB [P14927] | ubiquinol, cytochrome-c reductase (complex III) [CHEBI:26355, P14927, O14957, P07919, Q9Y276, P00156, O14949, CHEBI:30408, P22695, P31930, P47985, P0C7P4, Q9UDW1] | ||
re1632 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | UQCRC1 [P31930] | ubiquinol, cytochrome-c reductase (complex III) [CHEBI:26355, P14927, O14957, P07919, Q9Y276, P00156, O14949, CHEBI:30408, P22695, P31930, P47985, P0C7P4, Q9UDW1] | ||
re1633 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | COX7B [P24311] | cytochrome c oxidase (complex IV) [Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954] | ||
re1634 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | COX7A1 [P24310] | cytochrome c oxidase (complex IV) [Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954] | ||
re1635 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | COX7C [P15954] | cytochrome c oxidase (complex IV) [Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954] | ||
re1636 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | COX7A2L [O14548] | cytochrome c oxidase (complex IV) [Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954] | ||
re1637 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | COX7A2 [P14406] | cytochrome c oxidase (complex IV) [Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954] | ||
re1638 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | COX6A1 [P12074] | cytochrome c oxidase (complex IV) [Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954] | ||
re1639 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | COX5B [P10606] | cytochrome c oxidase (complex IV) [Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954] | ||
re1640 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | ATP5L [O75964] | F0F1-ATP synthase (complex V) [P36542, P48201, P25705, O75947, P30049, Q06055, P56385, O75964, P00846, P48047, Q9UII2, Q7Z4Y8, P05496, P06576, Q5VTU8, P56381, P03928, P18859, P56134, P24539] | ||
re1641 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | ATP5A1 [P25705] | F0F1-ATP synthase (complex V) [P36542, P48201, P25705, O75947, P30049, Q06055, P56385, O75964, P00846, P48047, Q9UII2, Q7Z4Y8, P05496, P06576, Q5VTU8, P56381, P03928, P18859, P56134, P24539] | ||
re1642 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | ATP5C1 [P36542] | F0F1-ATP synthase (complex V) [P36542, P48201, P25705, O75947, P30049, Q06055, P56385, O75964, P00846, P48047, Q9UII2, Q7Z4Y8, P05496, P06576, Q5VTU8, P56381, P03928, P18859, P56134, P24539] | ||
re1643 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | ATP5O [P48047] | F0F1-ATP synthase (complex V) [P36542, P48201, P25705, O75947, P30049, Q06055, P56385, O75964, P00846, P48047, Q9UII2, Q7Z4Y8, P05496, P06576, Q5VTU8, P56381, P03928, P18859, P56134, P24539] | ||
re1644 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | ATP5D [P30049] | F0F1-ATP synthase (complex V) [P36542, P48201, P25705, O75947, P30049, Q06055, P56385, O75964, P00846, P48047, Q9UII2, Q7Z4Y8, P05496, P06576, Q5VTU8, P56381, P03928, P18859, P56134, P24539] | ||
re1645 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | NDUFA8 [P51970] | NADH-Q oxireductase (complex I) [P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404] | ||
re1650 | mitochondrial outer membrane PINK1 / Parkin Pathway mitochondrial inner membrane cytosol | FIS1 [Q9Y3D6] | mitochondrial fission [] | ||
re1651 | Alpha-synuclein / Lewy Bodies cytosol | SNCA [P37840] | macroautophagy [] | s2462 [] | |
re1652 | Alpha-synuclein / Lewy Bodies cytosol | SNCA [P37840] | chaperone-mediated autophagy [] | s2464 [] | |
re1654 | Calcium Signalling cytosol | YWHAB [P31946], CRTC2 [Q53ET0] | TORC2:14-3-3 [P31946, Q53ET0] | ||
re1655 | Calcium Signalling cytosol | CRTC2 [Q53ET0] | SIK2 [Q9H0K1] | CRTC2 [Q53ET0] | |
re1656 | Calcium Signalling cytosol | cAMP/cGMP-dependent protein kinase [] | SIK2 [Q9H0K1] | ||
re1657 | Calcium Signalling cytosol | cAMP [CHEBI:17489] | cAMP/cGMP-dependent protein kinase [] | ||
re1658 | Calcium Signalling cytosol | ROS [CHEBI:26523] | autophagy [] | ||
re1659 | Autophagy / Mitophagy autolysosome cytosol | autolysosome [] | fatty acid [CHEBI:35366] | ||
re1660 | Autophagy / Mitophagy autolysosome cytosol | autolysosome [] | carbohydrate [CHEBI:16646] | ||
re1661 | Autophagy / Mitophagy autolysosome cytosol | autolysosome [] | nucleoside [CHEBI:33838] | ||
re1662 | Autophagy / Mitophagy cytosol | BCL2:BECN1 [Q14457, P10415] | MAPK8 [P45983] | BCL2 [P10415], BECN1 [Q14457] | |
re1664 | Autophagy / Mitophagy phagophore cytosol | ULK1 complex [O75143, Q8TDY2, Q9BSB4, O75385] | phagophore [] | ||
re1665 | Autophagy / Mitophagy cytosol | BECN1 [Q14457], BCL2 [P10415] | BCL2:BECN1 [Q14457, P10415] | ||
re1666 | Autophagy / Mitophagy phagophore cytosol | Class-III PI3K complex [Q9C0C7, Q14457, Q99570, Q8NEB9, Q6ZNE5] | phagophore [] | ||
re1667 | Autophagy / Mitophagy cytosol | ATG12 [O94817], ATG7 [O95352] | ATG12:ATG7 [O94817, O95352] | ||
re1668 | Autophagy / Mitophagy cytosol | ATG12:ATG7 [O94817, O95352], ATG10 [Q9H0Y0] | ATG12:ATG10 [Q9H0Y0, O94817], ATG7 [O95352] | ||
re1669 | Autophagy / Mitophagy cytosol | ATG12:ATG10 [Q9H0Y0, O94817], ATG5 [Q9H1Y0] | ATG12:ATG5 [O94817, Q9H1Y0], ATG10 [Q9H0Y0] | ||
re1670 | Autophagy / Mitophagy cytosol | ATG12:ATG5 [O94817, Q9H1Y0], ATG16L1 [Q676U5] | ATG12:ATG5:ATG16L1 [O94817, Q9H1Y0, Q676U5] | ||
re1671 | Autophagy / Mitophagy cytosol | MAP1LC3A [Q9H492] | ATG4B [Q9Y4P1] | MAP1LC3A (LC3-I) [Q9H492] | |
re1672 | Autophagy / Mitophagy cytosol | LC3-I:ATG7 [O95352, Q9H492], ATG3 [Q9NT62] | LC3-I:ATG3 [Q9NT62, Q9H492], ATG7 [O95352] | ||
re1673 | Autophagy / Mitophagy cytosol | LC3-I:ATG3 [Q9NT62, Q9H492], phosphatidylethanolamine [CHEBI:16038] | ATG12:ATG5:ATG16L1 [O94817, Q9H1Y0, Q676U5] | LC3-II [CHEBI:16038, Q9H492], ATG3 [Q9NT62] | |
re1674 | ROS-dependent NFE2L2 Signalling cytosol | NFE2L2 [Q16236] | s2485 [] | ||
re1676 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | FIS1 [Q9Y3D6] | PINK1:PARK2 [O60260, Q9BXM7] | s2486 [] | |
re1677 | mitochondrial outer membrane Calcium Signalling mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | CYCS [P99999] | CYCS [P99999] | ||
re1678 | microglia Microglia | MAPK cascade [] | microglia activation [] | ||
re1679 | Inflammation Signalling / Apoptosis cytosol | CHUK [O15111], IKBKB [O14920], IKBKG [Q9Y6K9] | IKK complex [O15111, Q9Y6K9, O14920] | ||
re1680 | Inflammation Signalling / Apoptosis nucleus cytosol | NF-kappa B [P19838, Q04206] | NF-kB [P19838, Q04206] | ||
re1681 | Dopamine Secretion / Recycling cytosol | RIMS1 [Q86UR5] | s2490 [] | ||
re1682 | Alpha-synuclein / Lewy Bodies endolysosome lysosome cytosol | endolysosome [] | lysosome [] | ||
re1684 | Autophagy / Mitophagy cytosol | ULK1:ATG13 [O75143, O75385] | s2495 [] | ||
re1685 | PINK1 / Parkin Pathway Autophagy / Mitophagy cytosol | ULK1:ATG13 [O75143, O75385], HSP90:CDC37 [Q16543, P07900] | HSP90:CDC37:ULK1:ATG13 [O75143, Q16543, P07900, O75385] | ||
re1686 | PINK1 / Parkin Pathway Autophagy / Mitophagy cytosol | HSP90:CDC37:ULK1:ATG13 [O75143, Q16543, P07900, O75385] | HSP90:CDC37:ULK1:ATG13 [O75143, Q16543, P07900, O75385] | ||
re1687 | PINK1 / Parkin Pathway cytosol | HSP90:CDC37:ULK1:ATG13 [O75143, Q16543, P07900, O75385] | ATG13 [O75143], HSP90:CDC37:ULK1 [Q16543, P07900, O75385] | ||
re1688 | PINK1 / Parkin Pathway cytosol | HSP90:CDC37:ULK1 [Q16543, P07900, O75385] | HSP90:CDC37 [Q16543, P07900], ULK1 [O75385] | ||
re1689 | PINK1 / Parkin Pathway Autophagy / Mitophagy cytosol | ULK1 [O75385] | s2495 [] | ||
re1690 | PINK1 / Parkin Pathway cytosol | ATG13 [O75143] | mitophagy [] | ||
re1691 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | VDAC1 [P21796] | mitophagy [] | ||
re1692 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | SQSTM1 [Q13501] | PINK1:PARK2 [O60260, Q9BXM7] | SQSTM1 [Q13501] | |
re1693 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | SQSTM1 [Q13501] | mitophagy [] | ||
re1694 | autophagosome PINK1 / Parkin Pathway mitochondrion Autophagy / Mitophagy cytosol | mitochondrion [], LC3-II [CHEBI:16038, Q9H492], ATG13 [O75143] | mitophagy [] | autophagosome [] | |
re1695 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | ROS [CHEBI:26523] | mitochondrial depolarization [] | ||
re1697 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial ROS Metabolism cytosol | paraquat monocation radical [], O2 [CHEBI:15379] | paraquat dication [], superoxide [CHEBI:18421] | ||
re1698 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain Mitochondrial ROS Metabolism cytosol | paraquat dication [] | NADH-Q oxireductase (complex I) [P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404], superoxide [CHEBI:18421] | paraquat monocation radical [] | |
re1699 | microglia Microglia | microglia activation [] | IL6 [P05231] | ||
re1700 | PINK1 / Parkin Pathway cytosol | DNM1L [O00429] | UPS [] | s2505 [] | |
re1702 | Ubiquitin Proteasome System cytosol | E2:ubiquitin [], E1:ubiquitin complex [P22314, A0AVT1, P0CG48, P0CG47, CHEBI:16027] | Ubiquitin-conjugating enzyme, E2 [], E1:ubiquitin complex [P22314, A0AVT1, P0CG48, P0CG47, CHEBI:16027] | ||
re1703 | Ubiquitin Proteasome System cytosol | ubiquitin [P0CG48, P0CG47], ATP [CHEBI:15422] | UBL-acyl adenylate intermediate [P0CG48, P0CG47, CHEBI:16027], diphosphate ion [CHEBI:29888,CHEBI:35782] | ||
re1704 | Ubiquitin Proteasome System cytosol | generic protein [], 26S hybrid proteasome [Q15008, O00487, O00233, Q16186, P17980, P28070, P62191, O00231, O14818, P49720, P25788, P28074, Q99436, Q99460, P28066, P28072, P60900, P25787, P49721, P62195, P51665, O43242, P25786, P55036, P25789, P43686, O00232, P62333, P20618, P48556, P35998, Q13200] | HSP70 [Q9Y4L1], diffusion [], shutling factors [P54727, P54725] | proteasome:substrate complex [] | |
re1705 | Ubiquitin Proteasome System cytosol | generic protein [] | protein deubiquitination [] | generic protein [] | |
re1712 | cytosol | TNFRSF1B [P20333] | TNF [P01375] | TNFRSF1B [P20333] | |
re1713 | Inflammation Signalling / Apoptosis cytosol | TNFRSF1B [P20333] | MAP3K7 [O43318] | ||
re1753 | ROS-dependent NFE2L2 Signalling cytosol nucleus | YAF2 [] | NFE2L2 [Q16236] | YAF2 [] | |
re1754 | ROS-dependent NFE2L2 Signalling cytosol nucleus | SLC25A25 [] | NFE2L2 [Q16236] | SLC25A25 [] | |
re1755 | ROS-dependent NFE2L2 Signalling cytosol nucleus | FTH1 [] | NFE2L2 [Q16236] | FTH1 [] | |
re1756 | ROS-dependent NFE2L2 Signalling cytosol nucleus | SLC7A11 [] | NFE2L2 [Q16236] | SLC7A11 [] | |
re1757 | ROS-dependent NFE2L2 Signalling cytosol nucleus | ABCC1 [] | NFE2L2 [Q16236] | ABCC1 [] | |
re1758 | ROS-dependent NFE2L2 Signalling cytosol nucleus | G6PD [] | NFE2L2 [Q16236] | G6PD [] | |
re1759 | ROS-dependent NFE2L2 Signalling cytosol nucleus | BLVRB [] | NFE2L2 [Q16236] | BLVRB [] | |
re1760 | ROS-dependent NFE2L2 Signalling cytosol nucleus | GCLM [] | NFE2L2 [Q16236] | GCLM [] | |
re1761 | ROS-dependent NFE2L2 Signalling cytosol nucleus | AOX1 [] | NFE2L2 [Q16236] | AOX1 [] | |
re1762 | ROS-dependent NFE2L2 Signalling cytosol nucleus | IDH1 [] | NFE2L2 [Q16236] | IDH1 [] | |
re1763 | ROS-dependent NFE2L2 Signalling cytosol nucleus | TXN [] | NFE2L2 [Q16236] | TXN [] | |
re1764 | ROS-dependent NFE2L2 Signalling cytosol nucleus | TKT [] | NFE2L2 [Q16236] | TKT [] | |
re1765 | ROS-dependent NFE2L2 Signalling cytosol nucleus | NQO1 [] | NFE2L2 [Q16236] | NQO1 [] | |
re1766 | ROS-dependent NFE2L2 Signalling cytosol nucleus | CEBPA [] | NFE2L2 [Q16236] | CEBPA [] | |
re1767 | ROS-dependent NFE2L2 Signalling cytosol nucleus | HES1 [] | NFE2L2 [Q16236] | HES1 [] | |
re1768 | ROS-dependent NFE2L2 Signalling cytosol nucleus | PRDX1 [] | NFE2L2 [Q16236] | PRDX1 [] | |
re1769 | ROS-dependent NFE2L2 Signalling cytosol nucleus | GCLC [] | NFE2L2 [Q16236] | GCLC [] | |
re1770 | ROS-dependent NFE2L2 Signalling cytosol nucleus | ADO [] | NFE2L2 [Q16236] | ADO [] | |
re1771 | ROS-dependent NFE2L2 Signalling cytosol nucleus | ABCB6 [] | NFE2L2 [Q16236] | ABCB6 [] | |
re1772 | ROS-dependent NFE2L2 Signalling cytosol nucleus | GSTA4 [] | NFE2L2 [Q16236] | GSTA4 [] | |
re1773 | ROS-dependent NFE2L2 Signalling cytosol nucleus | AHR [] | NFE2L2 [Q16236] | AHR [] | |
re1774 | ROS-dependent NFE2L2 Signalling cytosol nucleus | LPL [] | NFE2L2 [Q16236] | LPL [] | |
re1775 | ROS-dependent NFE2L2 Signalling cytosol nucleus | SRXN1 [] | NFE2L2 [Q16236] | SRXN1 [] | |
re1776 | ROS-dependent NFE2L2 Signalling cytosol nucleus | GSTM2 [] | NFE2L2 [Q16236] | GSTM2 [] | |
re1777 | ROS-dependent NFE2L2 Signalling cytosol nucleus | MYC [] | NFE2L2 [Q16236] | MYC [] | |
re1778 | ROS-dependent NFE2L2 Signalling cytosol nucleus | GSR [] | NFE2L2 [Q16236] | GSR [] | |
re1779 | ROS-dependent NFE2L2 Signalling cytosol nucleus | FECH [] | NFE2L2 [Q16236] | FECH [] | |
re1780 | ROS-dependent NFE2L2 Signalling cytosol nucleus | TXNRD1 [] | NFE2L2 [Q16236] | TXNRD1 [] | |
re1781 | ROS-dependent NFE2L2 Signalling cytosol nucleus | FTL [] | NFE2L2 [Q16236] | FTL [] | |
re1782 | ROS-dependent NFE2L2 Signalling cytosol nucleus | HMOX1 [] | NFE2L2 [Q16236] | HMOX1 [] | |
re1783 | ROS-dependent NFE2L2 Signalling cytosol nucleus | MAFG [] | NFE2L2 [Q16236] | MAFG [] | |
re1784 | ROS-dependent NFE2L2 Signalling cytosol nucleus | ABCC5 [] | NFE2L2 [Q16236] | ABCC5 [] | |
re1785 | ROS-dependent NFE2L2 Signalling cytosol nucleus | SLC44A3 [] | NFE2L2 [Q16236] | SLC44A3 [] | |
re1786 | ROS-dependent NFE2L2 Signalling cytosol nucleus | GSTM3 [] | NFE2L2 [Q16236] | GSTM3 [] | |
re1787 | ROS-dependent NFE2L2 Signalling cytosol nucleus | RXRA [] | NFE2L2 [Q16236] | RXRA [] | |
re1788 | ROS-dependent NFE2L2 Signalling cytosol nucleus | MGST2 [] | NFE2L2 [Q16236] | MGST2 [] | |
re1789 | ROS-dependent NFE2L2 Signalling cytosol nucleus | SLC48A1 [] | NFE2L2 [Q16236] | SLC48A1 [] | |
re1790 | ROS-dependent NFE2L2 Signalling cytosol nucleus | EPHX1 [] | NFE2L2 [Q16236] | EPHX1 [] | |
re1791 | ROS-dependent NFE2L2 Signalling cytosol nucleus | SQSTM1 [] | NFE2L2 [Q16236] | SQSTM1 [] | |
re1792 | lysosome Autophagy / Mitophagy autolysosome cytosol | autolysosome [] | lysosome [] | ||
re1812 | Autophagy / Mitophagy cytosol | PINK1 [Q9BXM7] | BECN1 [Q14457] | ||
re1824 | mitochondrial outer membrane PINK1 / Parkin Pathway mitochondrial inner membrane cytosol | PARL [Q9H300] | OPA1 [O60313] | ||
re1832 | Microtubules MAPT/Tau Phosphorylation cytosol | HSP70 [Q9Y4L1] | MAPT [P10636] | ||
re1845 | PINK1 / Parkin Pathway cytosol | NEDD8 [Q15843] | PINK1 [Q9BXM7] | ||
re1848 | Autophagy / Mitophagy cytosol | USP13 [Q92995] | BECN1 [Q14457] | ||
re1852 | Autophagy / Mitophagy cytosol | ELAVL1 [Q15717] | MCL1 [Q07820] | ||
re1853 | Calcium Signalling cytosol nucleus | MAPK p38 [] | PPARGC1A [Q9UBK2] | ||
re1866 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | MARK2 [Q7KZI7] | PINK1 [Q9BXM7] | ||
re1872 | Calcium Signalling cytosol nucleus | LRPPRC [P42704] | PPARGC1A [Q9UBK2] | ||
re1875 | Autophagy / Mitophagy cytosol | MYD88 [Q99836] | BECN1 [Q14457] | ||
re1879 | Apoptosis cytosol | NR4A1 [P22736] | BCL2 [P10415] | ||
re1891 | Autophagy / Mitophagy cytosol | DAPK1 [P53355] | BECN1 [Q14457] | ||
re1898 | cytosol | PIN1 [Q13526] | BCL2L11 [O43521] | ||
re1905 | cytosol | PIN1 [Q13526] | JUN [P05412] | ||
re1906 | Microtubules cytosol | HSP90 [P07900] | FGFR3 [P22607] | ||
re1909 | Postsynaptic terminal GABAergic Neuron | RANBP9 [Q96S59] | PRKCD [Q05655] | ||
re1911 | cytosol | PIN1 [Q13526] | NOS3 [P29474] | ||
re1917 | Autophagy / Mitophagy cytosol | BECN1 [Q14457] | BIRC5 [O15392] | ||
re1924 | cytosol | PIN1 [Q13526] | NR4A3 [Q92570] | ||
re1925 | mitochondrial outer membrane cytosol | VDAC1 [P21796] | NOS3 [P29474] | ||
re1941 | Inflammation Signalling / Apoptosis cytosol | PINK1 [Q9BXM7] | TRAF2:TRAF6 [Q9Y4K3, Q12933] | ||
re1951 | cytosol | RANBP9 [Q96S59] | NTRK2 [Q16620] | ||
re1952 | Calcium Signalling cytosol nucleus | PPARGC1A [Q9UBK2] | FOXO3 [O43524] | ||
re1958 | cytosol | PIN1 [Q13526] | CAST [P20810] | ||
re1959 | Calcium Signalling cytosol nucleus | PPARGC1A [Q9UBK2] | AR [P10275] | ||
re1962 | Calcium Signalling cytosol nucleus | PPARGC1A [Q9UBK2] | MEF2C [Q06413] | ||
re1970 | cytosol | PIN1 [Q13526] | MAPK8 [P45983] | ||
re1975 | cytosol | RANBP9 [Q96S59] | ITGB1 [P05556] | ||
re1984 | Calcium Signalling cytosol nucleus | PPARGC1A [Q9UBK2] | VDR [P11473] | ||
re1987 | cytosol | PIN1 [Q13526] | NR4A1 [P22736] | ||
re1988 | cytosol | PIN1 [Q13526] | CTNND2 [Q9UQB3] | ||
re1993 | Inflammation Signalling / Apoptosis cytosol | PINK1 [Q9BXM7] | MAP3K7 [O43318] | ||
re1996 | PINK1 / Parkin Pathway ER Fatty Acid / Ketone Body Metabolism cytosol | ITPR1 [Q14643] | BECN1 [Q14457] | ||
re2000 | cytosol | HTT [P42858] | UPS [] | ||
re2003 | Ubiquitin Proteasome System cytosol | STUB1 [Q9UNE7] | ATXN3 [P54252] | ||
re2007 | late endosome cytosol | MIR367 [] | VPS29:VPS26:VPS29 [Q96QK1, Q4G0F5, O75436, Q9UBQ0] | ||
re2010 | Dopamine Secretion / Recycling early endosome cytosol | MIR367 [] | VPS29:VPS26:VPS35 [Q96QK1, Q4G0F5, O75436, Q9UBQ0] | ||
re2011 | Dopamine Secretion / Recycling early endosome cytosol | MIR367 [] | VPS29:VPS26:VPS35 [Q96QK1, Q4G0F5, O75436, Q9UBQ0] | ||
re2014 | mitochondrial outer membrane cytosol | MIR367 [] | VPS26:VPS35:MUL1 [Q96QK1, Q4G0F5, O75436, Q969V5] | ||
re2016 | Autophagy / Mitophagy cytosol | KIAA0226 [Q92622] | BECN1 [Q14457] | ||
re2020 | Calcium Signalling cytosol nucleus | CLK2 [P49760] | PPARGC1A [Q9UBK2] | ||
re2023 | Calcium Signalling cytosol nucleus | ESRRA [P11474] | PPARGC1A [Q9UBK2] | ||
re2039 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | MARCH5 [Q9NX47] | MFN1 [Q8IWA4] | ||
re2047 | Ubiquitin Proteasome System cytosol | UPS [] | ATXN3 [P54252] | ||
re2049 | Calcium Signalling cytosol nucleus | RNF139 [Q8WU17] | SREBF1 [P36956] | ||
re2050 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | MIR155 [] | TRAK1 [Q9UPV9] | ||
re2058 | Microtubules cytosol | YWHAB [P31946] | BCL2L11 [O43521] | ||
re2127 | cytosol | HTT [P42858] | HSP70 [Q9Y4L1] | ||
re2148 | Microtubules MAPT/Tau Phosphorylation cytosol | NPEPPS [P55786] | MAPT [P10636] | ||
re2155 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | MAPK9 [P45984] | MFN2 [O95140] | ||
re2157 | Autophagy / Mitophagy cytosol | ATG12 [O94817] | MCL1 [Q07820] | ||
re2168 | Dopamine Secretion / Recycling dopamine-loaded synaptic vesicle cytosol | HSPA8 [P11142] | SLC18A2 [Q05940] | ||
re2187 | Apoptosis cytosol | GRAMD4 [Q6IC98] | BCL2 [P10415] | ||
re2218 | Calcium Signalling cytosol nucleus | GSK3 alpha/beta [P49840, P49841] | SREBF1 [P36956] | ||
re2238 | Autophagy / Mitophagy cytosol | NEDD4 [P46934] | BECN1 [Q14457] | ||
re2246 | mitochondrial outer membrane Apoptosis cytosol | NEK1 [Q96PY6] | VDAC1 [P21796] | ||
re2256 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | AKAP1 [Q92667] | DNM1L [O00429] | ||
re2261 | Dopamine Secretion / Recycling dopamine-loaded synaptic vesicle cytosol | DHTBZ [] | SLC18A2 [Q05940] | ||
re2267 | Calcium Signalling cytosol nucleus | PIAS1 [O75925] | PPARGC1A [Q9UBK2] | ||
re2270 | Apoptosis cytosol | BCL2 [P10415] | Alpha tubulin [] | ||
re2280 | cytosol | PIN1 [Q13526] | APP [P05067] | ||
re2281 | cytosol | PIN1 [Q13526] | PPARG [P37231] | ||
re2282 | Microtubules microtubule cytosol | HSP90 [P07900] | Tubulin [Q9UJT0] | ||
re2283 | Microtubules cytosol | HSP90 [P07900] | APP [P05067] | ||
re2284 | Postsynaptic terminal GABAergic Neuron | RANBP9 [Q96S59] | DRD1 [P21728] | ||
re2286 | cytosol | HSP70 [Q9Y4L1] | APP [P05067] | ||
re2289 | Apoptosis cytosol | BCL2 [P10415] | Beta tubulin [] | ||
re2302 | cytosol | HSP70 [Q9Y4L1] | AURKA [O14965] | ||
re2305 | cytosol | PIN1 [Q13526] | GSK3B [P49841] | ||
re2309 | Dopamine Secretion / Recycling docked dynaptic vesicle cytosol | SYT12 [Q8IV01] | SYT1 [P21579] | ||
re2326 | PINK1 / Parkin Pathway cytosol | ATXN3 [P54252] | PARK2 [O60260] | ||
re2344 | ROS-dependent NFE2L2 Signalling cytosol | PIN1 [Q13526] | NFE2L2 [Q16236] | ||
re2346 | cytosol | UPS [] | HTT [P42858] | ||
re2348 | cytosol | HSP70 [Q9Y4L1] | HTT [P42858] | ||
re2359 | Apoptosis cytosol | PIN1 [Q13526] | BAX [Q07812] | ||
re2368 | late endosome cytosol | VPS29:VPS26:VPS29 [Q96QK1, Q4G0F5, O75436, Q9UBQ0] | BACE1 [P56817] | ||
re2371 | Dopamine Secretion / Recycling early endosome cytosol | VPS29:VPS26:VPS35 [Q96QK1, Q4G0F5, O75436, Q9UBQ0] | BACE1 [P56817] | ||
re2380 | Calcium Signalling cytosol nucleus | PPARGC1A [Q9UBK2] | SMARCD1 [Q96GM5] | ||
re2393 | Microtubules MAPT/Tau Phosphorylation cytosol | MAPT [P10636] | DCTN1 [Q14203] | ||
re2397 | Microtubules MAPT/Tau Phosphorylation cytosol | FKBP4 [Q02790] | MAPT [P10636] | ||
re2405 | Microtubules MAPT/Tau Phosphorylation cytosol | SQSTM1 [Q13501] | MAPT [P10636] | ||
re2421 | Microtubules MAPT/Tau Phosphorylation cytosol | TRAF6 [Q9Y4K3] | MAPT [P10636] | ||
re2443 | Calcium Signalling cytosol nucleus | FBXW7 [Q969H0] | PPARGC1A [Q9UBK2] | ||
re2446 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | BAK1 [Q16611] | MFN2 [O95140] | ||
re2454 | Calcium Signalling cytosol nucleus | GSK3B [P49841] | PPARGC1A [Q9UBK2] | ||
re2457 | Microtubules cytosol | MIR29B1 [] | BCL2L11 [O43521] | ||
re2465 | Apoptosis cytosol | caspase-6 [P55212] | MAPT [P10636] | ||
re2468 | Apoptosis cytosol | MIR449A [] | BCL2 [P10415] | ||
re2483 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | SENP5 [Q96HI0] | DNM1L [O00429] | ||
re2701 | Apoptosis cytosol | MAPK8 [P45983] | BCL2 [P10415] | ||
re2721 | Microtubules cytosol | BTRC [Q9Y297] | BCL2L11 [O43521] | ||
re2732 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | VAT1 [P54219] | MFN1 [Q8IWA4] | ||
re2734 | Autophagy / Mitophagy cytosol | TAB2 [Q9NYJ8] | BECN1 [Q14457] | ||
re2738 | Calcium Signalling cytosol nucleus | PROX1 [Q92786] | PPARGC1A [Q9UBK2] | ||
re2743 | Microtubules MAPT/Tau Phosphorylation cytosol | Protein kinase C, alpha/beta/gamma types [] | MAPT [P10636] | ||
re2745 | mitochondrial outer membrane Apoptosis cytosol | GSN [P06396] | VDAC1 [P21796] | ||
re2752 | Calcium Signalling cytosol nucleus | CAPN1 [P07384] | PPARGC1A [Q9UBK2] | ||
re2755 | Microtubules cytosol | NDRG1 [Q92597] | BCL2L11 [O43521] | ||
re2766 | Ubiquitin Proteasome System cytosol | STUB1 [Q9UNE7] | HSP70 [Q9Y4L1] | ||
re2768 | cytosol | FAF1 [Q9UNN5] | HSP70 [Q9Y4L1] | ||
re2775 | Calcium Signalling cytosol | GDNF [P39905], GFRA1 [P56159] | GFRA1 receptor [P39905, P56159] | ||
re2776 | Calcium Signalling cytosol | GFRA1 receptor [P39905, P56159], RET [P07949] | RET receptor tyrosine kinase complex [P39905, P56159, P07949] | ||
re2777 | Calcium Signalling cytosol | RET receptor tyrosine kinase complex [P39905, P56159, P07949] | ERK1 and ERK2 cascade [] | ||
re2781 | Calcium Signalling cytosol nucleus | PPARGC1A [] | CREB dependent transcription [] | PPARGC1A [] | |
re2783 | Calcium Signalling cytosol nucleus | NR4A2 [] | CREB dependent transcription [], PPARGC1A [Q9UBK2] | NR4A2 [] | |
re2785 | cytosol nucleus | PITX3 [] | NR4A2 [P43354] | PITX3 [] | |
re2786 | cytosol nucleus | PITX3 [] | MIR133B [] | PITX3 [O75364] | |
re2787 | cytosol nucleus | TH [] | PITX3 [O75364], NR4A2 [P43354] | TH [] | |
re2788 | cytosol nucleus | GDNF [] | PITX3 [O75364] | GDNF [] | |
re2789 | cytosol nucleus | BDNF [] | PITX3 [O75364] | BDNF [] | |
re2790 | cytosol nucleus | MIR133B [] | PITX3 [O75364] | MIR133B [] | |
re2794 | cytosol nucleus | SOD1 [] | NR4A2 [P43354] | SOD1 [] | |
re2795 | cytosol nucleus | NDUFB8 [] | NR4A2 [P43354] | NDUFB8 [] | |
re2796 | cytosol nucleus | COX8A [] | NR4A2 [P43354] | COX8A [] | |
re2797 | cytosol nucleus | COX5B [] | NR4A2 [P43354] | COX5B [] | |
re2798 | cytosol nucleus | COX5A [] | NR4A2 [P43354] | COX5A [] | |
re2799 | cytosol nucleus | COX6A1 [] | NR4A2 [P43354] | COX6A1 [] | |
re2800 | cytosol nucleus | MRP63 [] | NR4A2 [P43354] | MRP63 [] | |
re2801 | cytosol nucleus | TSFM [] | NR4A2 [P43354] | TSFM [] | |
re2802 | cytosol nucleus | SLC18A2 [] | NR4A2 [P43354] | SLC18A2 [] | |
re2803 | cytosol nucleus | RET [] | NR4A2 [P43354] | RET [] | |
re2804 | cytosol nucleus | SLC6A3 [] | NR4A2 [P43354] | SLC6A3 [] | |
re2805 | cytosol nucleus | DDC [] | NR4A2 [P43354] | DDC [] | |
re2806 | cytosol nucleus | DRD2 [] | NR4A2 [P43354] | DRD2 [] | |
re2807 | cytosol nucleus | VIP [] | NR4A2 [P43354] | VIP [] | |
re2822 | cytosol nucleus | ADCYAP1 [] | NR4A2 [P43354] | ADCYAP1 [] | |
re2824 | cytosol nucleus | CFLAR [] | NR4A2 [P43354] | CFLAR [] | |
re2826 | cytosol nucleus | ABL2 [] | NR4A2 [P43354] | ABL2 [] | |
re2830 | cytosol nucleus | SESN3 [] | NR4A2 [P43354] | SESN3 [] | |
re2832 | cytosol nucleus | ADM [] | NR4A2 [P43354] | ADM [] | |
re2834 | cytosol nucleus | ACVR2B [] | NR4A2 [P43354] | ACVR2B [] | |
re2836 | cytosol nucleus | IGF2BP1 [] | NR4A2 [P43354] | IGF2BP1 [] | |
re2838 | cytosol nucleus | EIF4EBP2 [] | NR4A2 [P43354] | EIF4EBP2 [] | |
re2840 | cytosol nucleus | DDX6 [] | NR4A2 [P43354] | DDX6 [] | |
re2842 | cytosol nucleus | NR4A2 [P43354], PIN1 [Q13526] | PIN1 NR4A2 [P43354, Q13526] | ||
re2843 | Calcium Signalling cytosol | ionomycin [] | calcium ion transport into cytosol [] | ||
re2844 | Calcium Signalling Glutathione metabolism cytosol nucleus | response to oxidative stress [] | CREB dependent transcription [] | ||
re2845 | cytosol nucleus | PITX3 [O75364] | PITX3 [O75364] | ||
re2846 | Calcium Signalling cytosol | SNCA [P37840] | ERK1 and ERK2 cascade [] | ||
re2847 | Calcium Signalling cytosol | RET receptor tyrosine kinase complex [P39905, P56159, P07949] | Akt pathway [] | ||
re2848 | Calcium Signalling cytosol | SNCA [P37840] | Akt pathway [] | ||
re2849 | Calcium Signalling cytosol nucleus | NR4A2 [P43354] | NR4A2 [P43354] | ||
re2850 | cytosol | GSK3B [P49841] | Akt pathway [], rotenone [] | GSK3B [P49841] | |
re2851 | Apoptosis cytosol | MCL1 [Q07820] | GSK3B [P49841], MAPK10 [P53779] | MCL1 [Q07820] | |
re2852 | Apoptosis cytosol | MCL1 [Q07820] | TRIM17 [Q9Y577] | MCL1 [Q07820] | |
re2853 | Apoptosis cytosol | MCL1 [Q07820] | UPS [] | s3065 [] | |
re2854 | mitochondrial outer membrane Apoptosis cytosol | CYCS [P99999] | VDAC1 [P21796] | CYCS [P99999] | |
re2856 | Apoptosis cytosol | PIN1 [Q13526], MCL1 [Q07820] | PIN1 MCL1 Complex [Q07820, Q13526] | ||
re2857 | Apoptosis cytosol | BCL2L11 [O43521] | GSK3B [P49841] | BCL2L11 [O43521] | |
re2858 | Apoptosis cytosol | BAX [Q07812] | GSK3B [P49841] | BAX [Q07812] | |
re2859 | mitochondrial outer membrane cytosol | BCL2L11 [O43521] | MAPK8IP3 MAPK10 [Q9UPT6, P53779] | BCL2L11 [O43521] | |
re2860 | mitochondrial outer membrane cytosol | BCL2L11 [O43521], PIN1 [Q13526] | BIMEL PIN1 [Q13526, O43521] | ||
re2861 | mitochondrial outer membrane Apoptosis cytosol | HK2 [P52789], VDAC1 [P21796] | HK2:VDAC1 [P21796, P52789] | ||
re2862 | mitochondrial outer membrane Apoptosis cytosol | VDAC1 [P21796] | GSK3B [P49841] | VDAC1 [P21796] | |
re2863 | cytosol | lithium chloride [CHEBI:48607] | GSK3B [P49841] | ||
re2865 | cytosol | CTNNB1 [P35222] | GSK3B [P49841], WNT signalosome [P56703, P35222, O75197, P54792, O75581, P49841, Q9UP38, Q5S007], PIN1 [Q13526] | CTNNB1 [P35222] | |
re2866 | cytosol | FZD1 receptor [P04628, Q9UP38] | CTNNB1 [P35222] | ||
re2867 | cytosol | FZD1 receptor [P04628, Q9UP38] | GSK3B [P49841] | ||
re2868 | astrocyte cytosol | FZD1 [Q9UP38], WNT1 [P04628] | astrocyte activation [] | FZD1 receptor [P04628, Q9UP38] | |
re2869 | cytosol | CTNNB1 [P35222] | PARK2 [O60260] | CTNNB1 [P35222] | |
re2870 | cytosol | CTNNB1 [P35222] | s3088 [] | ||
re2871 | cytosol nucleus | CTNNB1 [P35222] | NR4A2 [P43354] | ||
re2872 | cytosol | WNT3 [P56703], FZD1 [Q9UP38] | WNT signalosome [P56703, P35222, O75197, P54792, O75581, P49841, Q9UP38, Q5S007] | ||
re2875 | Microtubules MAPT/Tau Phosphorylation cytosol | MAPT [P10636] | MAPK10 [P53779], MAPK9 [P45984], MAPK1 [P28482] | MAPT [P10636] | |
re2877 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | NDUFB8 [O95169] | NADH-Q oxireductase (complex I) [P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404] | ||
re2878 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | COX8A [P10176] | cytochrome c oxidase (complex IV) [Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954] | ||
re2879 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | COX5B [P10606] | cytochrome c oxidase (complex IV) [Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954] | ||
re2880 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | COX5A [P20674] | cytochrome c oxidase (complex IV) [Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954] | ||
re2881 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | COX6A1 [P12074] | cytochrome c oxidase (complex IV) [Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954] | ||
re2882 | mitochondrial outer membrane Apoptosis cytosol | MCL1 [Q07820] | intrinsic apoptosis [] | ||
re2890 | Calcium Signalling cytosol | AMPA receptor [P48058, P42261, P42263, P42262], L-Glutamate [CHEBI:29988] | AMPA receptor (Ca impermeable) [CHEBI:29988, P48058, P42261, P42263, P42262] | ||
re2892 | PINK1 / Parkin Pathway cytosol | Beta tubulin [] | UPS [] | s2404 [] | |
re2893 | Microtubules cytosol | MIR29B2 [] | BCL2L11 [O43521] | ||
re2920 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | OXPHOS subunits encoded in mtDNA [P00156, P03897, P00395, P03901, P00846, P00414, P03923, P00403, P03886, P03928, P03891, P03915, P03905] | NADH-Q oxireductase (complex I) [P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404] | ||
re2921 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | OXPHOS assembly factors [] | F0F1-ATP synthase (complex V) [P36542, P48201, P25705, O75947, P30049, Q06055, P56385, O75964, P00846, P48047, Q9UII2, Q7Z4Y8, P05496, P06576, Q5VTU8, P56381, P03928, P18859, P56134, P24539] | ||
re2922 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | OXPHOS assembly factors [] | cytochrome c oxidase (complex IV) [Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954] | ||
re2923 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | OXPHOS assembly factors [] | ubiquinol, cytochrome-c reductase (complex III) [CHEBI:26355, P14927, O14957, P07919, Q9Y276, P00156, O14949, CHEBI:30408, P22695, P31930, P47985, P0C7P4, Q9UDW1] | ||
re2924 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | OXPHOS assembly factors [] | NADH-Q oxireductase (complex I) [P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404] | ||
re2925 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain Glycolysis cytosol | OXPHOS assembly factors [] | Succinate dehydrogenase (complex II) [CHEBI:16238, CHEBI:30408, O14521, P21912, Q99643, P31040] | ||
re2927 | mitochondrial outer membrane PINK1 / Parkin Pathway mitochondrial inner membrane cytosol | mitochondrial fusion [] | mitochondrial depolarization [] | ||
re2929 | mitochondrial outer membrane PINK1 / Parkin Pathway mitochondrial inner membrane Fatty Acid / Ketone Body Metabolism cytosol | mitochondrial fission [] | mtDNA damage [] | ||
re2930 | mitochondrial outer membrane PINK1 / Parkin Pathway mitochondrial inner membrane Fatty Acid / Ketone Body Metabolism cytosol | mitochondrial fusion [] | mtDNA damage [] | ||
re2931 | Postsynaptic terminal GABAergic Neuron | ADORA2A [P29274] | DRD2 [P14416] | ||
re2932 | Postsynaptic terminal Dopamine Secretion / Recycling GABAergic Neuron | caffeine [CHEBI:27732] | ADORA2A [P29274] | ||
re2934 | Postsynaptic terminal GABAergic Neuron | A2A receptor antagonist [] | ADORA2A [P29274] | ||
re2935 | Postsynaptic terminal Dopamine Secretion / Recycling GABAergic Neuron | dopamine [CHEBI:18243] | DRD2 [P14416] | ||
re2936 | Postsynaptic terminal GABAergic Neuron | GNAL [P38405] | adenylate cyclase activity [] | ||
re2937 | Postsynaptic terminal GABAergic Neuron | DRD2 [P14416] | adenylate cyclase activity [] | ||
re2938 | Postsynaptic terminal GABAergic Neuron | adenylate cyclase activity [] | cAMP [CHEBI:17489] | ||
re2939 | Postsynaptic terminal GABAergic Neuron | cAMP [CHEBI:17489] | PKA [] | ||
re2940 | Postsynaptic terminal GABAergic Neuron | PKA [] | CREB dependent transcription [] | ||
re2942 | Postsynaptic terminal GABAergic Neuron | ADORA2A [P29274] | PI3K cascade [] | ||
re2943 | Postsynaptic terminal GABAergic Neuron | ADORA2A [P29274] | GNAL [P38405] | ||
re2944 | Postsynaptic terminal Dopamine Secretion / Recycling GABAergic Neuron | adenosine [CHEBI:16335] | ADORA2A [P29274] | ||
re2948 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | O2 [CHEBI:15379] | NADH-Q oxireductase (complex I) [P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404], ubiquinol, cytochrome-c reductase (complex III) [CHEBI:26355, P14927, O14957, P07919, Q9Y276, P00156, O14949, CHEBI:30408, P22695, P31930, P47985, P0C7P4, Q9UDW1], rotenone [], myxothiazol [] | superoxide [CHEBI:18421] | |
re2950 | Alpha-synuclein / Lewy Bodies cytosol | misfolded [P37840] | ROS [CHEBI:26523], NO [CHEBI:16480], PARK7 [Q99497], geldanamycin [] | protofibril [P37840] | |
re2953 | cytosol nucleus | PRKAA2 [P54646] | NR4A2 [P43354] | PRKAA2 [P54646] | |
re2954 | microglia Microglia cytosol | neuron death [] | cell surface PRR signaling pathway [] | ||
re2955 | cytosol | 26S proteasome [], Actin-related protein [] | NMDA receptor complex [CHEBI:15428, Q13224, Q14957, Q15334, Q13554, Q9UQM7, Q12879, P35609, CHEBI:29988, O15399, Q99996, Q05586, P07196, Q13555, Q13557] | anchored proteasome [] | |
re2956 | mitochondrial outer membrane mitochondrial inner membrane cytosol | SLC25A27 [O95847] | SLC25A27 [O95847] | ||
re2962 | mitochondrial outer membrane mitochondrial inner membrane cytosol | superoxide [CHEBI:18421] | UCP2 [P55851] | ||
re2963 | mitochondrial outer membrane mitochondrial inner membrane cytosol | superoxide [CHEBI:18421] | UCP3 [P55916] | ||
re2964 | PINK1 / Parkin Pathway cytosol | mitophagy [] | SNCA [P37840] | neuron death [] | |
re2965 | Calcium Signalling cytosol | L-glutamate [CHEBI:29988] | calcium ion transport into cytosol [] | ||
re2966 | Postsynaptic terminal GABAergic Neuron | DRD1 [P21728] | PRKCD [Q05655] | DRD1 [P21728] | |
re2968 | Calcium Signalling cytosol | PRDX2 [P32119] | CDK5-p25 [Q15078, Q00535] | PRDX2 [P32119] | |
re2969 | Calcium Signalling cytosol | CDK5-p35 [Q15078, Q00535] | CAPN1 [P07384], MPP+ [] | CDK5-p25 [Q15078, Q00535] | |
re2978 | ROS-dependent NFE2L2 Signalling cytosol nucleus | GSS [] | NFE2L2 [Q16236] | GSS [] | |
re2979 | ROS-dependent NFE2L2 Signalling cytosol nucleus | SLC1A1 [] | NFE2L2 [Q16236] | SLC1A1 [] | |
re2980 | ROS-dependent NFE2L2 Signalling cytosol nucleus | GGT1 [] | NFE2L2 [Q16236] | GGT1 [] | |
re2981 | ROS-dependent NFE2L2 Signalling cytosol nucleus | GSTP1 [] | NFE2L2 [Q16236] | GSTP1 [] | |
re2985 | ROS-dependent NFE2L2 Signalling cytosol | PARK7 [Q99497] | ROS/RNS [] | PARK7 [Q99497] | |
re2986 | ROS-dependent NFE2L2 Signalling cytosol | PARK7 [Q99497] | ROS/RNS [] | PARK7 [Q99497] | |
re2987 | ROS-dependent NFE2L2 Signalling cytosol | PARK7 [Q99497] | ROS/RNS [] | UPS [] | |
re2988 | ROS-dependent NFE2L2 Signalling cytosol | KEAP1 [Q14145], PARK7 [Q99497] | PARK7-KEAP1 [Q99497, Q14145] | ||
re2989 | ROS-dependent NFE2L2 Signalling cytosol | PARK7 [Q99497], KEAP1 [Q14145] | PARK7-KEAP1 [Q99497, Q14145] | ||
re2990 | Inflammation Signalling / Apoptosis Apoptosis cytosol | GSTP1 [P09211], MAPK8 [P45983] | ROS [CHEBI:26523], MPP+ [] | JNK-GSTP1 [P09211, P45983] | |
re2993 | Apoptosis cytosol | GSTP1 [P09211], TRAF2 [Q12933] | TRAF2-GSTP1 [P09211, Q12933] | ||
re2994 | Inflammation Signalling / Apoptosis Apoptosis cytosol | TRAF2 [Q12933] | TRAF2:TRAF6 [Q9Y4K3, Q12933] | ||
re2995 | Inflammation Signalling / Apoptosis nucleus cytosol | PARK-DAXX [Q99497, Q9UER7] | ROS [CHEBI:26523] | PARK7 [Q99497], DAXX [Q9UER7] | |
re2996 | Inflammation Signalling / Apoptosis cytosol | DAXX [Q9UER7], MAP3K5 [Q99683] | ASK1-DAXX [Q9UER7, Q99683] | ||
re2997 | Inflammation Signalling / Apoptosis cytosol | ASK1-DAXX [Q9UER7, Q99683] | apoptosis [] | ||
re3000 | Calcium Signalling cytosol | GSTP1 [P09211] | ROS/RNS [] | GSTP1 [P09211] | |
re3001 | Calcium Signalling cytosol | GSTP1 [P09211] | ROS/RNS [] | UPS [] | |
re3005 | Ubiquitin Proteasome System cytosol | glutathione [CHEBI:16856], 26S hybrid proteasome [Q15008, O00487, O00233, Q16186, P17980, P28070, P62191, O00231, O14818, P49720, P25788, P28074, Q99436, Q99460, P28066, P28072, P60900, P25787, P49721, P62195, P51665, O43242, P25786, P55036, P25789, P43686, O00232, P62333, P20618, P48556, P35998, Q13200] | ROS [CHEBI:26523] | 26S hybrid proteasome [P28066] | |
re3006 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain Glutathione metabolism cytosol | MPP+ [] | Acetylated NADH-Q oxireductase (complex I) [P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404] | ||
re3007 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | glutathione [CHEBI:16856] | SLC25A11 [Q02978], SLC25A10 [Q9UBX3] | glutathione [CHEBI:16856] | |
re3114 | astrocyte Glutathione metabolism Blood-Brain Barrier | L-glutamic acid [CHEBI:16015] | SLC7A11 [Q9UPY5] | L-glutamic acid [CHEBI:16015] | |
re3115 | astrocyte Glutathione metabolism | glycine [CHEBI:15428], yGluCys [] | GSS [P48637] | glutathione [CHEBI:16856] | |
re3116 | astrocyte Calcium Signalling Glutathione metabolism | glutathione [CHEBI:16856] | ABCB1 [P08183] | glutathione [CHEBI:16856] | |
re3117 | astrocyte Calcium Signalling Glutathione metabolism | glutathione [CHEBI:16856] | GGT1 [P19440] | CysGly [] | |
re3118 | Calcium Signalling Glutathione metabolism cytosol | CysGly [] | ANPEP [P15144] | L-cysteine [CHEBI:17561] | |
re3119 | Glutathione metabolism cytosol | L-cysteine [CHEBI:17561], L-glutamic acid [CHEBI:16015] | GCLM [P48507], GCLC [P48506] | yGluCys [] | |
re3120 | Glutathione metabolism cytosol | glycine [CHEBI:15428], yGluCys [] | GSS [P48637] | glutathione [CHEBI:16856] | |
re3121 | Glutathione metabolism cytosol | L-cysteine [CHEBI:17561] | SLC1A1 [P43005] | L-cysteine [CHEBI:17561] | |
re3122 | Glutathione metabolism cytosol | MPP+ [] | SLC1A1 [P43005] | ||
re3123 | Glutathione metabolism cytosol | MPP+ [] | SLC6A3 [Q01959] | MPP+ [] | |
re3124 | Glutathione metabolism cytosol | MPP-SG [] | drug transmembrane transporter activity [] | MPP-SG [] | |
re3125 | Glutathione metabolism cytosol | glutathione [CHEBI:16856], MPP+ [] | GSTP1 [P09211] | MPP-SG [] | |
re3126 | astrocyte Glutathione metabolism blood vessel Blood-Brain Barrier | MTPT [] | MTPT [] | ||
re3127 | astrocyte mitochondrion Glutathione metabolism | MTPT [] | MAOB:FAD [CHEBI:16238, P27338] | MPP+ [] | |
re3128 | astrocyte Glutathione metabolism | MPP+ [] | MPP+ [] | ||
re3129 | Glutathione metabolism cytosol | glutathione [CHEBI:16856], generic protein [] | GSTP1 [P09211] | generic protein [] | |
re3130 | Glutathione metabolism cytosol | generic protein [] | drug transmembrane transporter activity [] | generic protein [] | |
re3131 | Glutathione metabolism cytosol | generic protein [] | ROS/RNS [] | generic protein [] | |
re3132 | Glutathione metabolism cytosol | generic protein [] | GLRX [P35754], TRX [P10599], GLRX2 [Q9NS18] | generic protein [], glutathione disulfide [CHEBI:17858] | |
re3133 | Glutathione metabolism cytosol | glutathione [CHEBI:16856], paraquat [] | GSTP1 [P09211] | Paraquat-SG [] | |
re3134 | Glutathione metabolism cytosol | Paraquat-SG [] | drug transmembrane transporter activity [] | Paraquat-SG [] | |
re3135 | Glutathione metabolism cytosol | electrophile [], glutathione [CHEBI:16856] | GSTP1 [P09211] | electrophile-SG [] | |
re3136 | Glutathione metabolism cytosol | electrophile-SG [] | drug transmembrane transporter activity [] | electrophile-SG [] | |
re3145 | endothelial cell Glutathione metabolism Blood-Brain Barrier | cystine [CHEBI:17376] | SLC7A5 [Q01650] | cystine [CHEBI:17376] | |
re3146 | endothelial cell blood vessel Blood-Brain Barrier | cystine [CHEBI:17376] | SLC7A11 [Q9UPY5] | cystine [CHEBI:17376] | |
re3147 | Glutathione metabolism cytosol | generic protein [] | ROS/RNS [] | UPS [] | |
re3148 | Glutathione metabolism cytosol | glutathione [CHEBI:16856], electrophile [] | electrophile-SG [] | ||
re3149 | astrocyte blood vessel Blood-Brain Barrier | glucose [CHEBI:17234] | GLUT1 [P11166] | glucose [CHEBI:17234] | |
re3150 | astrocyte Blood-Brain Barrier | glucose [CHEBI:17234] | (S)-lactate [CHEBI:16651] | ||
re3153 | astrocyte Glutathione metabolism Blood-Brain Barrier | cystine [CHEBI:17376] | SLC7A11 [Q9UPY5], SLC3A2 [P08195] | cystine [CHEBI:17376] | |
re3154 | astrocyte Glutathione metabolism Blood-Brain Barrier | cystine [CHEBI:17376] | L-cysteine [CHEBI:17561] | ||
re3155 | astrocyte Glutathione metabolism Blood-Brain Barrier | L-cysteine [CHEBI:17561], L-glutamic acid [CHEBI:16015] | GCLM [P48507], GCLC [P48506] | yGluCys [] | |
re3156 | Glutathione metabolism cytosol | ROS/RNS [] | SLC1A1 [P43005] | ||
re3168 | astrocyte Glycolysis cytosol | (S)-lactate [CHEBI:16651] | GLUT1 [P11166], GLUT3 [P11169] | (S)-lactate [CHEBI:16651] | |
re3169 | ROS-dependent NFE2L2 Signalling cytosol | KEAP1:CUL3 [Q13618, Q14145] | KEAP1 [Q14145], CUL3 [Q13618] | ||
re3170 | Glutathione metabolism cytosol | generic protein [], TRX [P10599] | generic protein [], TRX [P10599] | ||
re3171 | mitochondrial outer membrane cytosol | glutathione [CHEBI:16856] | glutathione [CHEBI:16856] | ||
re3177 | microglia Microglia | NADPH oxidase complex [P04839, P14598, Q9HBY0] | superoxide [CHEBI:18421] | ||
re3178 | superoxide [CHEBI:18421], NO [CHEBI:16480] | peroxynitrite [CHEBI:25941] | |||
re3179 | superoxide [CHEBI:18421] | ROS [CHEBI:26523] | |||
re3180 | peroxynitrite [CHEBI:25941] | ROS [CHEBI:26523] | |||
re3181 | Alpha-synuclein spreading cytosol | protofibril [P37840] | pinocytosis [] | protofibril [P37840] | |
re3184 | astrocyte | dopamine [CHEBI:18243] | COMT [P21964] | 3-O-Methyldopamine [CID 1669] | |
re3185 | astrocyte | 3-O-Methyldopamine [CID 1669] | MAOA:FAD [P21397, CHEBI:16238], MAOB:FAD [CHEBI:16238, P27338] | homovanillin [] | |
re3186 | astrocyte | dopamine [CHEBI:18243] | MAOA:FAD [P21397, CHEBI:16238], MAOB:FAD [CHEBI:16238, P27338] | DOPAL [CHEBI:27978] | |
re3187 | astrocyte | DOPAL [CHEBI:27978] | ALDH1A1 [P00352], ALDH3A1 [P30838], ALDH9A1 [P49189], ALDH2 [P05091] | DOPAC [CHEBI:41941] | |
re3188 | astrocyte | homovanillin [] | ALDH1A1 [P00352], ALDH2 [P05091], ALDH3A1 [P30838], ALDH9A1 [P49189] | homovanillic acid [CHEBI:545959] | |
re3189 | astrocyte | DOPAC [CHEBI:41941] | COMT [P21964] | homovanillic acid [CHEBI:545959] | |
re3190 | microglia Microglia | superoxide [CHEBI:18421], NO [CHEBI:16480] | peroxynitrite [CHEBI:25941] | ||
re3191 | Calcium Signalling cytosol nucleus | calcium ion transport into cytosol [] | CREB dependent transcription [] | ||
re3192 | Calcium Signalling cytosol | calcium ion transport into cytosol [] | Ca2+ [CHEBI:29108] | ||
re3193 | Ubiquitin Proteasome System cytosol | 26S hybrid proteasome [P28066] | UPS [] | ||
re3218 | mitochondrial outer membrane mitochondrial inner membrane nucleoid cytosol | mitochondrial DNA [] | mitochondrial transcription [] | mRNA [] | |
re3219 | mitochondrial outer membrane mitochondrial inner membrane nucleoid cytosol | mitochondrial DNA [] | Mt-dNTP pool [P53597, Q16854, Q7LG56, Q9P2R7, O00142], mtDNA damage [], TFAM [Q00059], Mt replication [Q9NVV4, P54098, Q96DP5, Q9UHN1] | mtDNA replication [] | |
re3220 | mitochondrial outer membrane mitochondrial inner membrane nucleoid cytosol | mtDNA repair [] | Mt-DNA repair [Q13216, P54098, Q03468], Mt-dNTP pool [P53597, Q16854, Q7LG56, Q9P2R7, O00142], TFAM [Q00059] | mitochondrial DNA [] | |
re3222 | mitochondrial outer membrane mitochondrial inner membrane nucleoid cytosol | TFAM [Q00059] | mitochondrial DNA [] | ||
re3223 | mitochondrial outer membrane mitochondrial inner membrane nucleoid cytosol | Mt ribosomal proteins [P82650, P09001, Q9Y3D3] | mitochondrial translation [] | ||
re3224 | mitochondrial outer membrane mitochondrial inner membrane nucleoid cytosol | Mt translation [P43897, Q96RR1, Q96RP9, Q9H3J6, P49411] | mitochondrial translation [] | ||
re3225 | mitochondrial outer membrane mitochondrial inner membrane nucleoid cytosol | mitochondrial DNA [] | Mt tRNA synthetases [P41250, Q5JTZ9, Q6PI48, Q15046, Q5T160] | mitochondrial tRNAs and rRNA [] | |
re3226 | mitochondrial outer membrane mitochondrial inner membrane nucleoid cytosol | mRNA [], mitochondrial tRNAs and rRNA [] | mitochondrial translation [] | OXPHOS subunits encoded in mtDNA [P00156, P03897, P00395, P03901, P00846, P00414, P03923, P00403, P03886, P03928, P03891, P03915, P03905] | |
re332 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | NADH [CHEBI:16908], ubiquinone [CHEBI:46245], H+ [CHEBI:15378] | NADH-Q oxireductase (complex I) [P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404], rotenone [], SNCA [P37840], SNCA [P37840] | NAD(+) [CHEBI:15846], H+ [CHEBI:15378], ubiquinol [CHEBI:17976] | |
re336 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | O2 [CHEBI:15379], CYCS [P99999], H+ [CHEBI:15378] | cytochrome c oxidase (complex IV) [Q02221, P12074, P14406, P00395, P24311, P13073, O14548, Q96KJ9, P00414, P00403, P10176, P10606, P20674, P24310, P15954] | H2O [CHEBI:15377], CYCS [P99999], H+ [CHEBI:15378] | |
re338 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial ROS Metabolism cytosol | O2 [CHEBI:15379] | superoxide [CHEBI:18421] | ||
re339 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial ROS Metabolism cytosol | superoxide [CHEBI:18421], H+ [CHEBI:15378] | SOD2 [P04179] | hydrogen peroxide [CHEBI:16240] | |
re340 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial ROS Metabolism cytosol | hydrogen peroxide [CHEBI:16240] | CAT [P04040] | H2O [CHEBI:15377], O2 [CHEBI:15379] | |
re341 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial ROS Metabolism cytosol | hydrogen peroxide [CHEBI:16240], TXN [P10599] | PRDX3 [P30048], PRDX5 [P30044] | H2O [CHEBI:15377], TXN [P10599] | |
re342 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial ROS Metabolism cytosol | NADPH [CHEBI:16474], TXN [P10599] | TXNRD2 [Q9NNW7] | NADP(+) [CHEBI:18009], TXN [P10599] | |
re343 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | O2 [CHEBI:15379] | ubiquinol [CHEBI:17976] | superoxide [CHEBI:18421] | |
re345 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial ROS Metabolism cytosol | hydrogen peroxide [CHEBI:16240], glutathione [CHEBI:16856] | GPX1 [P07203], GPX4 [P36969] | H2O [CHEBI:15377], glutathione disulfide [CHEBI:17858] | |
re346 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial ROS Metabolism cytosol | glutathione disulfide [CHEBI:17858], NADPH [CHEBI:16474] | GSR [P00390] | glutathione [CHEBI:16856], NADP(+) [CHEBI:18009] | |
re348 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial ROS Metabolism cytosol | superoxide [CHEBI:18421] | ROS [CHEBI:26523] | ||
re349 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial ROS Metabolism cytosol | hydrogen peroxide [CHEBI:16240] | ROS [CHEBI:26523] | ||
re360 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial ROS Metabolism cytosol | hydrogen peroxide [CHEBI:16240], Fe2+ [] | hydroxyl [CHEBI:29191], Fe3+ [], hydroxide [CHEBI:16234] | ||
re361 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial ROS Metabolism cytosol | hydroxyl [CHEBI:29191] | ROS [CHEBI:26523] | ||
re363 | mitochondrial outer membrane Mitochondrial Electron Transport Chain cytosol | superoxide [CHEBI:18421] | ROS [CHEBI:26523] | ||
re364 | mitochondrial outer membrane Mitochondrial Electron Transport Chain cytosol | hydrogen peroxide [CHEBI:16240] | ROS [CHEBI:26523] | ||
re366 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial ROS Metabolism cytosol | hydroxyl [CHEBI:29191], Fe2+ [] | hydroxide [CHEBI:16234], Fe3+ [] | ||
re368 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial ROS Metabolism cytosol | hydrogen peroxide [CHEBI:16240], hydroxyl [CHEBI:29191] | superoxide [CHEBI:18421], H2O [CHEBI:15377], H+ [CHEBI:15378] | ||
re369 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial ROS Metabolism cytosol | superoxide [CHEBI:18421], Fe3+ [] | O2 [CHEBI:15379], Fe2+ [] | ||
re372 | mitochondrial outer membrane mitochondrial inner membrane cytosol | ATP-sensitive K+ channel [Q14654, Q15842] | ATP [CHEBI:15422], Tiopronin [CID 5483], ROS [CHEBI:26523], diazoxide [] | ATP-sensitive K+ channel [Q14654, Q15842] | |
re373 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | K+ [CHEBI:29103] | ATP-sensitive K+ channel [Q14654, Q15842] | K+ [CHEBI:29103] | |
re374 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | ATP-sensitive K+ channel [Q14654, Q15842] | mitochondrial depolarization [] | ||
re377 | mitochondrial outer membrane Mitochondrial Electron Transport Chain cytosol | H+ [CHEBI:15378] | H+ [CHEBI:15378] | ||
re378 | mitochondrial outer membrane Mitochondrial Electron Transport Chain cytosol | H+ [CHEBI:15378] | H+ [CHEBI:15378] | ||
re379 | mitochondrial outer membrane Mitochondrial Electron Transport Chain cytosol | H+ [CHEBI:15378] | H+ [CHEBI:15378] | ||
re39 | Dopamine Metabolism cytosol | dopamine [CHEBI:18243] | COMT [P21964] | 3-O-Methyldopamine [CID 1669] | |
re40 | mitochondrion Dopamine Metabolism cytosol | 3-O-Methyldopamine [CID 1669] | MAOA:FAD [P21397, CHEBI:16238], MAOB:FAD [CHEBI:16238, P27338] | homovanillin [] | |
re41 | mitochondrion Dopamine Metabolism cytosol | dopamine [CHEBI:18243], H2O [CHEBI:15377], O2 [CHEBI:15379] | MAOA:FAD [P21397, CHEBI:16238], MAOB:FAD [CHEBI:16238, P27338] | DOPAL [CHEBI:27978], hydrogen peroxide [CHEBI:16240], ammonia [CHEBI:16134] | |
re42 | Dopamine Metabolism cytosol | DOPAL [CHEBI:27978] | ALDH1A1 [P00352], ALDH3A1 [P30838], ALDH9A1 [P49189], ALDH2 [P05091] | DOPAC [CHEBI:41941] | |
re424 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial ROS Metabolism cytosol | hydrogen peroxide [CHEBI:16240] | ROS [CHEBI:26523] | ||
re425 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial ROS Metabolism cytosol | superoxide [CHEBI:18421] | ROS [CHEBI:26523] | ||
re43 | Dopamine Metabolism cytosol | homovanillin [] | ALDH1A1 [P00352], ALDH2 [P05091], ALDH3A1 [P30838], ALDH9A1 [P49189] | homovanillic acid [CHEBI:545959] | |
re44 | Dopamine Metabolism cytosol | DOPAC [CHEBI:41941] | COMT [P21964] | homovanillic acid [CHEBI:545959] | |
re45 | Dopamine Metabolism cytosol | DOPAL [CHEBI:27978] | AKR1A1 [P14550], AKR1B1 [P15121] | DOPET [CID 82755] | |
re510 | Apoptosis cytosol | Caspase-2 [P42575] | CYCS [P99999] | ||
re512 | Apoptosis cytosol | CASP9 [P55211] | AKT1 [P31749] | CASP9 [P55211] | |
re513 | Apoptosis cytosol | CASP9 [P55211] | MAPK1 [P28482] | CASP9 [P55211] | |
re620 | Inflammation Signalling / Apoptosis cytosol | Thioredoxin:ASK1 [P10599, Q99683] | ROS [CHEBI:26523] | TXN [P10599], MAP3K5 [Q99683] | |
re621 | Inflammation Signalling / Apoptosis cytosol | MAP3K5 [Q99683], TRAF2:TRAF6 [Q9Y4K3, Q12933], TRAF2:TRAF6 [Q9Y4K3, Q12933] | ASK1 signalsome [Q99683, Q9Y4K3, Q12933] | ||
re622 | Inflammation Signalling / Apoptosis cytosol | ASK1 signalsome [Q99683, Q9Y4K3, Q12933] | ASK1 signalsome [Q99683, Q9Y4K3, Q12933] | ASK1 signalsome [Q99683, Q9Y4K3, Q12933] | |
re623 | Inflammation Signalling / Apoptosis cytosol | ASK1 signalsome [Q99683, Q9Y4K3, Q12933] | PPP5C [P53041] | ASK1 signalsome [Q99683, Q9Y4K3, Q12933] | |
re624 | Inflammation Signalling / Apoptosis Apoptosis cytosol | MAP2K4 [P45985] | ASK1 signalsome [Q99683, Q9Y4K3, Q12933], MAP3K7 [O43318] | MAP2K4 [P45985] | |
re625 | Inflammation Signalling / Apoptosis Apoptosis cytosol | MAP2K7 [O14733] | ASK1 signalsome [Q99683, Q9Y4K3, Q12933], MAP3K7 [O43318] | MAP2K7 [O14733] | |
re626 | Apoptosis cytosol | MAPK8 [P45983] | MAP2K4 [P45985], MAP2K7 [O14733] | MAPK8 [P45983] | |
re627 | Apoptosis cytosol | MAPK9 [P45984] | MAP2K4 [P45985], MAP2K7 [O14733] | MAPK9 [P45984] | |
re628 | Apoptosis cytosol | MAPK10 [P53779] | MAP2K4 [P45985], MAP2K7 [O14733] | MAPK10 [P53779] | |
re629 | Apoptosis cytosol | MAPK14 [Q16539] | MAP2K4 [P45985], MAP2K7 [O14733], MAP2K3 [P46734], MAP2K6 [P52564] | MAPK14 [Q16539] | |
re630 | mitochondrial outer membrane Apoptosis cytosol | MAPK8 [P45983] | BAX [Q07812] | ||
re631 | mitochondrial outer membrane Apoptosis cytosol | MAPK9 [P45984] | BAX [Q07812] | ||
re632 | mitochondrial outer membrane Apoptosis cytosol | MAPK10 [P53779] | BAX [Q07812] | ||
re633 | mitochondrial outer membrane Apoptosis cytosol | MAPK8 [P45983] | BAK1 [Q16611] | ||
re634 | mitochondrial outer membrane Apoptosis cytosol | MAPK9 [P45984] | BAK1 [Q16611] | ||
re635 | mitochondrial outer membrane Apoptosis cytosol | MAPK10 [P53779] | BAK1 [Q16611] | ||
re637 | cytosol | ROS [CHEBI:26523] | PARK7 [Q99497] | ||
re638 | Apoptosis cytosol | 14-3-3 zeta:Bax [Q07812, P63104] | MAPK8 [P45983] | YWHAZ [P63104], BAX [Q07812] | |
re639 | Apoptosis cytosol | 14-3-3 sigma:Bax [P31947, Q07812] | MAPK8 [P45983] | SFN [P31947], BAX [Q07812] | |
re655 | mitochondrial outer membrane Mitochondrial Electron Transport Chain cytosol | superoxide [CHEBI:18421], H+ [CHEBI:15378] | SOD1 [P00441] | hydrogen peroxide [CHEBI:16240] | |
re658 | Apoptosis cytosol | BAX [Q07812], XRCC6 [P12956] | Ku70:BAX complex [Q07812, P12956] | ||
re659 | Apoptosis cytosol | XRCC6 [P12956] | SIRT3 [Q9NTG7] | XRCC6 [P12956] | |
re66 | Alpha-synuclein / Lewy Bodies Dopamine Metabolism cytosol | SNCA [P37840] | PP2A [P67775, P62714] | ||
re67 | Dopamine Metabolism cytosol | Tyrosine 3-monooxygenase (Fe2+ cofactor) [] | PP2A [P67775, P62714] | Tyrosine 3-monooxygenase (Fe2+ cofactor) [] | |
re68 | Alpha-synuclein / Lewy Bodies cytosol | SNCA [P37840] | ROS [CHEBI:26523], NO [CHEBI:16480] | misfolded [P37840] | |
re696 | autophagosome lysosome Autophagy / Mitophagy autolysosome cytosol | autophagosome [], lysosome [] | VAMP8 [Q9BV40], VTI1B [Q9UEU0] | autolysosome [] | |
re697 | autophagosome Autophagy / Mitophagy phagophore cytosol | phagophore [], LC3-II [CHEBI:16038, Q9H492] | ATG12:ATG5:ATG16L1 [O94817, Q9H1Y0, Q676U5] | autophagosome [] | |
re701 | Autophagy / Mitophagy cytosol | BECN1 [Q14457], PIK3C3 [Q8NEB9], PIK3R4 [Q99570], ATG14 [Q6ZNE5], AMBRA1 [Q9C0C7] | Class-III PI3K complex [Q9C0C7, Q14457, Q99570, Q8NEB9, Q6ZNE5] | ||
re703 | Autophagy / Mitophagy cytosol | MAP1LC3A (LC3-I) [Q9H492], ATG7 [O95352] | LC3-I:ATG7 [O95352, Q9H492] | ||
re71 | Alpha-synuclein / Lewy Bodies cytosol | SNCA [P37840] | PLK2 [Q9NYY3], PLK3 [Q9H4B4] | SNCA [P37840] | |
re717 | Calcium Signalling cytosol nucleus | PPARGC1A [Q9UBK2] | SIRT1 [Q96EB6] | PPARGC1A [Q9UBK2] | |
re718 | Apoptosis cytosol | CASP2 [P42575] | PIDDsome [Q9HB75, P78560] | Caspase-2 [P42575] | |
re719 | Calcium Signalling cytosol nucleus | YY1:PGC1-alpha [P25490, Q9UBK2] | PPARGC1A [Q9UBK2] | ||
re720 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | Acetylated NADH-Q oxireductase (complex I) [P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404] | SIRT3 [Q9NTG7] | NADH-Q oxireductase (complex I) [P51970, O75489, Q16795, O95167, O43678, O95298, P56181, O75306, Q86Y39, P03901, O43920, Q9NX14, O00483, O14561, O95299, Q16718, O43181, O95178, O95168, O95169, P17568, Q9Y375, P03891, O75380, P03905, O95139, O43674, O75251, P28331, O95182, P03897, Q9Y6M9, P49821, P56556, O75438, O96000, O43676, Q9UI09, P03923, Q9P0J0, O43677, P03886, O00217, O15239, P03915, P19404] | |
re721 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain Glycolysis cytosol | Acetylated succinate dehydrogenase (complex II) [CHEBI:16238, CHEBI:30408, O14521, P21912, Q99643, P31040] | SIRT3 [Q9NTG7] | Succinate dehydrogenase (complex II) [CHEBI:16238, CHEBI:30408, O14521, P21912, Q99643, P31040] | |
re722 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial ROS Metabolism cytosol | SOD2 [P04179] | SIRT3 [Q9NTG7] | SOD2 [P04179] | |
re723 | Calcium Signalling cytosol nucleus | caloric restriction [] | SIRT1 [Q96EB6] | ||
re724 | mitochondrial outer membrane mitochondrial inner membrane TCA Cycle cytosol | Acetylated isocitrate dehydrogenase [] | SIRT3 [Q9NTG7] | isocitrate dehydrogenase [] | |
re725 | mitochondrial outer membrane mitochondrial inner membrane Mitochondrial Electron Transport Chain cytosol | CYCS [P99999] | SIRT5 [Q9NXA8] | CYCS [P99999] | |
re728 | cytosol nucleus | SLC25A27 [] | PARK7 [Q99497] | SLC25A27 [] | |
re729 | cytosol nucleus | SLC25A14 [] | PARK7 [Q99497] | SLC25A14 [] | |
re736 | Calcium Signalling cytosol nucleus | COX7A1 [] | PPARGC1A [Q9UBK2] | COX7A1 [] | |
re737 | Calcium Signalling cytosol nucleus | NDUFB6 [] | PPARGC1A [Q9UBK2] | NDUFB6 [] | |
re738 | Calcium Signalling cytosol nucleus | UQCRB [] | PPARGC1A [Q9UBK2] | UQCRB [] | |
re739 | Calcium Signalling cytosol nucleus | UQCRC1 [] | PPARGC1A [Q9UBK2] | UQCRC1 [] | |
re740 | Calcium Signalling cytosol nucleus | ATP5A1 [] | PPARGC1A [Q9UBK2] | ATP5A1 [] | |
re741 | Calcium Signalling cytosol nucleus | CYCS [] | PPARGC1A [Q9UBK2] | CYCS [] | |
re742 | Calcium Signalling cytosol nucleus | COX7C [] | PPARGC1A [Q9UBK2] | COX7C [] | |
re743 | Calcium Signalling cytosol nucleus | COX7A2L [] | PPARGC1A [Q9UBK2] | COX7A2L [] | |
re744 | Calcium Signalling cytosol nucleus | COX7A2 [] | PPARGC1A [Q9UBK2] | COX7A2 [] | |
re746 | Calcium Signalling cytosol nucleus | COX6A1 [] | PPARGC1A [Q9UBK2] | COX6A1 [] | |
re747 | Calcium Signalling cytosol nucleus | COX5B [] | PPARGC1A [Q9UBK2] | COX5B [] | |
re748 | Calcium Signalling cytosol nucleus | ATP5O [] | PPARGC1A [Q9UBK2] | ATP5O [] | |
re749 | Calcium Signalling cytosol nucleus | ATP5L [] | PPARGC1A [Q9UBK2] | ATP5L [] | |
re750 | Calcium Signalling cytosol nucleus | ATP5D [] | PPARGC1A [Q9UBK2] | ATP5D [] | |
re751 | Calcium Signalling cytosol nucleus | ATP5C1 [] | PPARGC1A [Q9UBK2] | ATP5C1 [] | |
re752 | Calcium Signalling cytosol nucleus | NDUFA8 [] | PPARGC1A [Q9UBK2] | NDUFA8 [] | |
re753 | Calcium Signalling cytosol nucleus | NDUFAB1 [] | PPARGC1A [Q9UBK2] | NDUFAB1 [] | |
re754 | Calcium Signalling cytosol nucleus | NDUFB3 [] | PPARGC1A [Q9UBK2] | NDUFB3 [] | |
re755 | Calcium Signalling cytosol nucleus | NDUFB5 [] | PPARGC1A [Q9UBK2] | NDUFB5 [] | |
re756 | Calcium Signalling cytosol nucleus | COX7B [] | PPARGC1A [Q9UBK2] | COX7B [] | |
re757 | Calcium Signalling cytosol nucleus | NDUFC1 [] | PPARGC1A [Q9UBK2] | NDUFC1 [] | |
re758 | Calcium Signalling cytosol nucleus | NDUFS3 [] | PPARGC1A [Q9UBK2] | NDUFS3 [] | |
re759 | Calcium Signalling cytosol nucleus | NDUFS5 [] | PPARGC1A [Q9UBK2] | NDUFS5 [] | |
re760 | Calcium Signalling cytosol nucleus | SDHA [] | PPARGC1A [Q9UBK2] | SDHA [] | |
re761 | Calcium Signalling cytosol nucleus | SDHB [] | PPARGC1A [Q9UBK2] | SDHB [] | |
re762 | Calcium Signalling cytosol nucleus | SLC25A4 [] | PPARGC1A [Q9UBK2] | SLC25A4 [] | |
re763 | Calcium Signalling cytosol nucleus | SLC25A5 [] | PPARGC1A [Q9UBK2] | SLC25A5 [] | |
re766 | mitochondrial outer membrane mitochondrial inner membrane cytosol | membrane permeability [] | mitochondrial dysfunction [] | ||
re769 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | VDAC1 [P21796] | PINK1:PARK2 [O60260, Q9BXM7] | VDAC1 [P21796] | |
re774 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | mitochondrial depolarization [] | mitophagy [] | ||
re775 | PINK1 / Parkin Pathway cytosol | ZNF746 [Q6NUN9] | PARK2 [O60260] | ZNF746 [Q6NUN9] | |
re776 | PINK1 / Parkin Pathway cytosol | ZNF746 [Q6NUN9] | UPS [] | s2404 [] | |
re777 | Calcium Signalling cytosol nucleus | PPARGC1A [] | ZNF746 [Q6NUN9], CREB dependent transcription [] | PPARGC1A [] | |
re782 | Autophagy / Mitophagy autolysosome cytosol | autolysosome [] | amino acid [CHEBI:33709] | ||
re783 | Calcium Signalling cytosol | ULK1 complex [O75143, Q8TDY2, Q9BSB4, O75385] | autophagy [] | ||
re784 | Calcium Signalling cytosol | ATG1 kinase complex [O75143, Q8TDY2, Q9BSB4, O75385] | mTOR complex 1 (mTORC1) [Q8N122, Q96B36, Q8TB45, P42345, Q9BVC4] | ATG1 kinase complex [O75143, Q8TDY2, Q9BSB4, O75385] | |
re791 | Calcium Signalling cytosol | TSC2 [P49815] | mTOR complex 1 (mTORC1) [Q8N122, Q96B36, Q8TB45, P42345, Q9BVC4] | ||
re792 | Calcium Signalling cytosol | amino acid [CHEBI:33709] | Ragulator:RAGA:RAGC [Q9UHA4, Q9Y2Q5, Q9NQL2, Q9HB90, Q6IAA8, Q7L523, Q5VZM2] | ||
re796 | Calcium Signalling cytosol | Ragulator:RAGA:RAGC [Q9UHA4, Q9Y2Q5, Q9NQL2, Q9HB90, Q6IAA8, Q7L523, Q5VZM2] | mTOR complex 1 (mTORC1) [Q8N122, Q96B36, Q8TB45, P42345, Q9BVC4] | ||
re800 | Calcium Signalling cytosol nucleus | mTOR complex 1 (mTORC1) [Q8N122, Q96B36, Q8TB45, P42345, Q9BVC4] | YY1:PGC1-alpha [P25490, Q9UBK2] | ||
re802 | mitochondrial outer membrane cytosol | peroxynitrite [CHEBI:25941] | membrane permeability [] | ||
re805 | Calcium Signalling cytosol | rapamycin [] | mTOR complex 1 (mTORC1) [Q8N122, Q96B36, Q8TB45, P42345, Q9BVC4] | ||
re807 | mitochondrial outer membrane PINK1 / Parkin Pathway cytosol | PARK2 [O60260], PINK1 [Q9BXM7] | CCCP [], ROS [CHEBI:26523] | PINK1:PARK2 [O60260, Q9BXM7] | |
re808 | mitochondrial outer membrane Apoptosis cytosol | VDAC1 [P21796], BCL2 [P10415] | BCL2:VDAC1 [P21796, P10415] | ||
re809 | mitochondrial outer membrane Apoptosis cytosol | VDAC1 [P21796] | intrinsic apoptosis [] | VDAC1 [P21796] | |
re810 | mitochondrial outer membrane mitochondrial inner membrane cytosol | Ca2+ [CHEBI:29108] | MICU1 [Q9BPX6] | Ca2+ [CHEBI:29108] | |
re811 | Alpha-synuclein / Lewy Bodies lysosome cytosol | misfolded [P37840] | LAMP2 [P13473], HSPA8 [P11142], SNCA [P37840], SNCA [P37840] | misfolded [P37840] | |
re812 | Alpha-synuclein / Lewy Bodies lysosome cytosol | misfolded [P37840] | GBA:PSAP [P04062, P07602], CTSD [P07339] | s1831 [] | |
re813 | Dopamine Secretion / Recycling cytosol | RIMS1 [Q86UR5] | SCF complex [Q13616, P63208, Q96IG2] | RIMS1 [Q86UR5] | |
re82 | mitochondrial outer membrane mitochondrial inner membrane cytosol | mitochondrial dysfunction [] | intrinsic apoptosis [] | ||
re84 | mitochondrial outer membrane mitochondrial inner membrane cytosol | ROS [CHEBI:26523] | mitochondrial dysfunction [] | ||
re884 | mitochondrial outer membrane mitochondrial inner membrane TCA Cycle cytosol | HMGCS2 [P54868] | SIRT3 [Q9NTG7] | HMGCS2 [P54868] | |
re890 | mitochondrial outer membrane mitochondrial inner membrane TCA Cycle cytosol | GLUD1 [P00367] | SIRT4 [Q9Y6E7] | GLUD1 [P00367] | |
re891 | mitochondrial outer membrane mitochondrial inner membrane TCA Cycle cytosol | caloric restriction [] | SIRT4 [Q9Y6E7] | ||
re892 | mitochondrial outer membrane mitochondrial inner membrane TCA Cycle cytosol | GLUD1 [P00367] | SIRT3 [Q9NTG7] | GLUD1 [P00367] | |
re904 | Calcium Signalling cytosol | Na+ [CHEBI:29101] | membrane depolarlization [] | ||
re905 | Calcium Signalling cytosol | Ca2+ [CHEBI:29108] | membrane depolarlization [] | ||
re924 | Calcium Signalling cytosol | MAPK1 [P28482] | MAPK1 [P28482] | ||
re926 | Calcium Signalling cytosol | AMPK [Q9Y478, Q9UGJ0, P54646, Q9UGI9, O43741, P54619, Q13131] | TSC2 [P49815] | ||
re933 | Calcium Signalling cytosol nucleus | ATF3 [] | CREB dependent transcription [] | ATF3 [] | |
re934 | Calcium Signalling cytosol nucleus | BTG2 [] | CREB dependent transcription [] | BTG2 [] | |
re935 | Calcium Signalling cytosol nucleus | BCL6 [] | CREB dependent transcription [] | BCL6 [] | |
re936 | Calcium Signalling cytosol nucleus | GADD45B [] | CREB dependent transcription [] | GADD45B [] | |
re937 | Calcium Signalling cytosol nucleus | GADD45G [] | CREB dependent transcription [] | GADD45G [] | |
re938 | Calcium Signalling cytosol nucleus | INHBA [] | CREB dependent transcription [] | INHBA [] | |
re940 | Calcium Signalling cytosol nucleus | NPAS4 [] | CREB dependent transcription [] | NPAS4 [] | |
re941 | Calcium Signalling cytosol nucleus | NR4A1 [] | CREB dependent transcription [] | NR4A1 [] | |
re942 | Calcium Signalling cytosol nucleus | SERPINB2 [] | CREB dependent transcription [] | SERPINB2 [] | |
re943 | Calcium Signalling cytosol nucleus | BDNF [] | CREB dependent transcription [] | BDNF [] | |
re944 | Calcium Signalling cytosol nucleus | CREB1 [P16220], CREBBP [Q92793] | CREB:CBP [Q92793, P16220] | ||
re945 | Calcium Signalling cytosol nucleus | CREBBP [Q92793] | Calmodulin:CaMK IV [P62158, CHEBI:29108, Q16566] | CREBBP [Q92793] | |
re946 | Calcium Signalling cytosol nucleus | CREB1 [P16220] | NSMF [] | CREB1 [P16220] | |
re947 | Calcium Signalling cytosol nucleus | NELF:importin alpha [] | NELF:importin alpha [] | ||
re958 | Calcium Signalling cytosol nucleus | NSMF [], Importin subunit alpha [] | NELF:importin alpha [] | ||
re959 | Calcium Signalling cytosol | NSMF [], CABP1 [Q9NZU7] | NELF:caldendrin [] | ||
re960 | Calcium Signalling cytosol nucleus | CREB1 [P16220], CRTC1 [Q6UUV9] | CREB:TORC1 [P16220, Q6UUV9] | ||
re961 | Calcium Signalling cytosol nucleus | CREB1 [P16220], CRTC2 [Q53ET0] | CREB:TORC2 [P16220, Q53ET0] | ||
re962 | Calcium Signalling cytosol nucleus | CREB:CBP [Q92793, P16220] | CREB dependent transcription [] | ||
re963 | Calcium Signalling cytosol nucleus | CREB:TORC2 [P16220, Q53ET0] | CREB dependent transcription [] | ||
re964 | Calcium Signalling cytosol nucleus | CREB:TORC1 [P16220, Q6UUV9] | CREB dependent transcription [] | ||
re970 | Calcium Signalling cytosol | Ca2+ [CHEBI:29108] | Calcinuerin [P16298, P48454, Q08209, Q96LZ3, P63098] | ||
re971 | Calcium Signalling cytosol | CRTC2 [Q53ET0] | Calcinuerin [P16298, P48454, Q08209, Q96LZ3, P63098] | CRTC2 [Q53ET0] | |
re972 | Calcium Signalling cytosol nucleus | CRTC2 [Q53ET0] | cAMP [CHEBI:17489], Ca2+ [CHEBI:29108] | CRTC2 [Q53ET0] | |
re973 | Calcium Signalling cytosol | Ca2+ [CHEBI:29108], CALM1 [P62158] | Calmodulin [P62158, CHEBI:29108] | ||
re975 | Calcium Signalling cytosol nucleus | CRTC1 [Q6UUV9] | Ca2+ [CHEBI:29108], cAMP [CHEBI:17489] | CRTC1 [Q6UUV9] | |
re976 | Calcium Signalling cytosol | ERK1 and ERK2 cascade [] | TSC2 [P49815] | ||
re977 | mitochondrial outer membrane Apoptosis cytosol | HTRA2 [O43464] | intrinsic apoptosis [] | HTRA2 [O43464] | |
re979 | Calcium Signalling cytosol | Akt pathway [] | TSC2 [P49815] |