diff --git a/frontend-js/src/main/js/ServerConnector.js b/frontend-js/src/main/js/ServerConnector.js
index bfde71174a8acc063017f8e2a50899b2825b1ae6..be1e48a07a4d4eb4d202ebfd10f5bb3e7f8101c8 100644
--- a/frontend-js/src/main/js/ServerConnector.js
+++ b/frontend-js/src/main/js/ServerConnector.js
@@ -736,6 +736,41 @@ ServerConnector.getDrugsByTargetUrl = function(params) {
   });
 };
 
+ServerConnector.getChemicalsByQueryUrl = function(params) {
+  var query = params.query;
+  var projectId = params.projectId;
+  var token = params.token;
+
+  return this.getApiUrl({type:"chemical",
+    method:"getChemicalsByQuery",
+    params: {
+      projectId: projectId, 
+      query: query, 
+      token: token},
+  });
+};
+
+ServerConnector.getChemicalsByTargetUrl = function(params) {
+  var query = params.query;
+  var projectId = params.projectId;
+  var token = params.token;
+  var columns = this.idsToString(params.columns);
+  var targetId = params.target.getId();
+  var targetType = params.target.getType();
+  
+  return this.getApiUrl({type:"chemical",
+    method:"getChemicalsByTarget",
+    params: {
+      projectId: projectId, 
+      query: query, 
+      columns: columns, 
+      token: token,
+      targetId: targetId,
+      targetType: targetType,
+      },
+  });
+};
+
 ServerConnector.getConfigurationParam = function(paramId) {
   var self = this;
   return new Promise(function(resolve, reject) {
@@ -1023,6 +1058,28 @@ ServerConnector.getDrugsByQuery = function(params) {
   });
 };
 
+ServerConnector.getChemicalsByQuery = function(params) {
+  var self = this;
+  return new Promise(function(resolve, reject) {
+    return self.getProjectId(params.projectId).then(function(result) {
+      params.projectId = result;
+      return self.getToken();
+    }).then(function(token) {
+      params.token = token;
+      return self.readFile(self.getChemicalsByQueryUrl(params));
+    }).then(function(content) {
+      var array=JSON.parse(content);
+      var result = [];
+      for (var i = 0; i < array.length; i++) {
+        result.push(new Drug(array[i]));
+      }
+      resolve(result);
+    }).catch(function(exception){
+      reject(exception);
+    });
+  });
+};
+
 ServerConnector.getDrugNamesByTarget = function(params) {
   var self = this;
   params.columns = ["name"];
@@ -1046,6 +1103,29 @@ ServerConnector.getDrugNamesByTarget = function(params) {
   });
 };
 
+ServerConnector.getChemicalNamesByTarget = function(params) {
+  var self = this;
+  params.columns = ["name"];
+  return new Promise(function(resolve, reject) {
+    return self.getProjectId(params.projectId).then(function(result) {
+      params.projectId = result;
+      return self.getToken();
+    }).then(function(token) {
+      params.token = token;
+      return self.readFile(self.getChemicalsByTargetUrl(params));
+    }).then(function(content) {
+      var result = [];
+      var object = JSON.parse(content);
+      for (var i=0;i<object.length;i++){
+        result.push(object[i].name);
+      }
+      resolve(result);
+    }).catch(function(exception){
+      reject(exception);
+    });
+  });
+};
+
 ServerConnector.addComment = function(params) {
   var self = this;
   return new Promise(function(resolve, reject) {
diff --git a/frontend-js/src/main/js/SessionData.js b/frontend-js/src/main/js/SessionData.js
index 7c58c887b95e14baaf14f596582a65dd5a5fe6d0..392790edefa78eb57aa95e2da226a121e9059325 100644
--- a/frontend-js/src/main/js/SessionData.js
+++ b/frontend-js/src/main/js/SessionData.js
@@ -34,6 +34,8 @@ SessionData.prototype.setQuery = function(param) {
     this.setDrugQuery(param.query);
   } else if (param.type === "search") {
     this.setSearchQuery(param.query);
+  } else if (param.type === "chemical") {
+    this.setChemicalQuery(param.query);
   } else {
     throw new Error("Invalid query type: " + param.type);
   }
@@ -62,6 +64,20 @@ SessionData.prototype.getDrugQuery = function() {
   return result;
 };
 
+SessionData.prototype.setChemicalQuery = function(value) {
+  var key = this.getKey(SessionObjectType.CHEMICAL_QUERY);
+  Cookies.set(key, JSON.stringify(value));
+};
+
+SessionData.prototype.getChemicalQuery = function() {
+  var key = this.getKey(SessionObjectType.CHEMICAL_QUERY);
+  var result = Cookies.get(key);
+  if (result !== undefined) {
+    result = JSON.parse(result);
+  }
+  return result;
+};
+
 SessionData.prototype.setShowComments = function(value) {
   var key = this.getKey(SessionObjectType.SHOW_COMMENT);
   Cookies.set(key, value + "");
diff --git a/frontend-js/src/main/js/SessionObjectType.js b/frontend-js/src/main/js/SessionObjectType.js
index 1148eb5d079c1854b965997d27644e57d79909fd..616d9e66218ea2a073de15dc9d80b874bdb873b0 100644
--- a/frontend-js/src/main/js/SessionObjectType.js
+++ b/frontend-js/src/main/js/SessionObjectType.js
@@ -1,6 +1,7 @@
 "use strict";
 
 var SessionObjectType = {
+  CHEMICAL_QUERY : "CHEMICAL_QUERY",
   DRUG_QUERY : "DRUG_QUERY",
   SHOW_COMMENT : "SHOW_COMMENT",
   SELECTED_BACKGROUND_OVERLAY : "SELECTED_BACKGROUND_OVERLAY",
diff --git a/frontend-js/src/main/js/map/overlay/ChemicalDbOverlay.js b/frontend-js/src/main/js/map/overlay/ChemicalDbOverlay.js
new file mode 100644
index 0000000000000000000000000000000000000000..19e3fcfa2bf8f68bd413f31c1646a59b9113a9db
--- /dev/null
+++ b/frontend-js/src/main/js/map/overlay/ChemicalDbOverlay.js
@@ -0,0 +1,31 @@
+"use strict";
+
+var logger = require('../../logger');
+
+var Promise = require("bluebird");
+
+var IdentifiedElement = require('../data/IdentifiedElement');
+var AbstractTargettingDbOverlay = require('./AbstractTargettingDbOverlay');
+
+var ServerConnector = require('../../ServerConnector');
+
+function ChemicalDbOverlay(params) {
+  params.iconType= "ball";
+  params.iconColorStart = 1;
+  // call super constructor
+  AbstractTargettingDbOverlay.call(this, params);
+  
+}
+
+ChemicalDbOverlay.prototype = Object.create(AbstractTargettingDbOverlay.prototype);
+ChemicalDbOverlay.prototype.constructor = ChemicalDbOverlay;
+
+ChemicalDbOverlay.prototype.getNamesByTargetFromServer = function(param) {
+  return ServerConnector.getChemicalNamesByTarget(param);
+}
+
+ChemicalDbOverlay.prototype.getElementsByQueryFromServer = function(param) {
+  return ServerConnector.getChemicalsByQuery(param);
+}
+
+module.exports = ChemicalDbOverlay;
diff --git a/frontend-js/src/test/js/helper.js b/frontend-js/src/test/js/helper.js
index 3d75b1b79544808bdd1670b5444dcaf4ebc9e973..1d4ac957d7a33108d3cb23ed14adb70da28b9996 100644
--- a/frontend-js/src/test/js/helper.js
+++ b/frontend-js/src/test/js/helper.js
@@ -4,6 +4,7 @@ require("./mocha-config");
 
 var Alias = require("../../main/js/map/data/Alias");
 var AbstractCustomMap = require("../../main/js/map/AbstractCustomMap");
+var ChemicalDbOverlay = require("../../main/js/map/overlay/ChemicalDbOverlay");
 var Comment = require("../../main/js/map/data/Comment");
 var CommentDbOverlay = require("../../main/js/map/overlay/CommentDbOverlay");
 var CustomMap = require("../../main/js/map/CustomMap");
@@ -99,6 +100,17 @@ Helper.prototype.createDrugDbOverlay = function(map) {
   return result;
 };
 
+Helper.prototype.createChemicalDbOverlay = function(map) {
+  var result = new ChemicalDbOverlay({
+    map : map,
+    name : "chemical",
+    allowGeneralSearch : true,
+    allowSearchById : true,
+  });
+  map.registerSource(result);
+  return result;
+};
+
 Helper.prototype.createComment = function(element) {
   var elementType = "ALIAS";
   var elementId = this.idCounter++;
diff --git a/frontend-js/src/test/js/map/overlay/ChemicalDbOverlay-test.js b/frontend-js/src/test/js/map/overlay/ChemicalDbOverlay-test.js
new file mode 100644
index 0000000000000000000000000000000000000000..f73b9ebddc27671462a8b94a0ba5275f45cd1307
--- /dev/null
+++ b/frontend-js/src/test/js/map/overlay/ChemicalDbOverlay-test.js
@@ -0,0 +1,65 @@
+"use strict";
+
+var Helper = require('../../Helper');
+
+var logger = require('../../logger');
+
+var IdentifiedElement = require('../../../../main/js/map/data/IdentifiedElement');
+var ChemicalDbOverlay = require('../../../../main/js/map/overlay/ChemicalDbOverlay');
+
+var assert = require('assert');
+
+describe('ChemicalDbOverlay', function() {
+  var helper;
+  before(function() {
+    helper = new Helper();
+  });
+
+  it("constructor 1", function() {
+    var map = helper.createCustomMap();
+    var oc = new ChemicalDbOverlay({
+      map : map,
+      name : 'chemical'
+    });
+    assert.ok(oc);
+    assert.equal(oc.getName(), 'chemical');
+
+    assert.equal(logger.getWarnings.length, 0);
+  });
+
+  it("searchByQuery", function() {
+    var map = helper.createCustomMap();
+    map.getModel().setId(15781);
+    var searchDb = helper.createChemicalDbOverlay(map);
+    return searchDb.searchByQuery("rotenone").then(function(chemicals) {
+      assert.equal(chemicals.length, 1);
+      assert.equal(searchDb.getQueries().length, 1);
+      return searchDb.getElementsByQuery(searchDb.getQueries()[0]);
+    }).then(function(elements) {
+      //these are targets
+      assert.ok(elements.length>0);
+      var chemical = elements.element;
+      assert.equal(chemical.getName(), "Rotenone");
+      return searchDb.getIdentifiedElements();
+    }).then(function(elements) {
+      assert.equal(elements.length,0);
+    });
+  });
+
+  it("searchNamesByTarget", function() {
+    var map = helper.createCustomMap();
+    map.getModel().setId(15781);
+    var searchDb = helper.createChemicalDbOverlay(map);
+
+    var target = new IdentifiedElement({
+      type : "ALIAS",
+      id : 329170,
+      modelId : 15781,
+    });
+
+    return searchDb.searchNamesByTarget(target).then(function(chemicalNames) {
+      assert.equal(chemicalNames.length, 0);
+    });
+  });
+
+});
diff --git a/frontend-js/testFiles/apiCalls/chemical/getChemicalsByQuery/projectId=sample&query=rotenone&token=MOCK_TOKEN_ID& b/frontend-js/testFiles/apiCalls/chemical/getChemicalsByQuery/projectId=sample&query=rotenone&token=MOCK_TOKEN_ID&
new file mode 100644
index 0000000000000000000000000000000000000000..8f223c5699efb05be5f4230652eea8e83227f8ae
--- /dev/null
+++ b/frontend-js/testFiles/apiCalls/chemical/getChemicalsByQuery/projectId=sample&query=rotenone&token=MOCK_TOKEN_ID&
@@ -0,0 +1 @@
+[{"directevidence":"marker/mechanism","references":[{"name":"D012402","type":"Toxicogenomic Chemical","link":"http://ctdbase.org/detail.go?type\u003dchem\u0026acc\u003dD012402","idObject":0},{"name":"83-79-4","type":"Chemical Abstracts Service","link":"http://commonchemistry.org/ChemicalDetail.aspx?ref\u003d83-79-4","idObject":0}],"synonyms":[],"directevidencereferences":[],"name":"Rotenone","description":"A botanical insecticide that is an inhibitor of mitochondrial electron transport.","id":"Rotenone","targets":[{"targetElements":[],"references":[{"title":"In vitro search for synergy between flavonoids and epirubicin on multidrug-resistant cancer cells.","authors":["Gyémánt N"," Tanaka M"," Antus S"," Hohmann J"," Csuka O"," Mándoky L"," Molnár J."],"journal":"In vivo (Athens, Greece)","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15796199","id":"15796199","citationCount":14}],"name":"ABCB1","targetParticipants":[{"name":"ABCB1","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dABCB1","idObject":0}]},{"targetElements":[],"references":[{"title":"Rotenone-induced neurotoxicity in rat brain areas: a study on neuronal and neuronal supportive cells.","authors":["Swarnkar S"," Goswami P"," Kamat PK"," Patro IK"," Singh S"," Nath C."],"journal":"Neuroscience","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23098804","id":"23098804","citationCount":4}],"name":"AIF1","targetParticipants":[{"name":"AIF1","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dAIF1","idObject":0}]},{"targetElements":[],"references":[{"title":"Characterization of cellular protective effects of ATP13A2/PARK9 expression and alterations resulting from pathogenic mutants.","authors":["Covy JP"," Waxman EA"," Giasson BI."],"journal":"Journal of neuroscience research","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22847264","id":"22847264","citationCount":10}],"name":"ATP13A2","targetParticipants":[{"name":"ATP13A2","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dATP13A2","idObject":0}]},{"targetElements":[],"references":[{"title":"AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro.","authors":["Bogush A"," Pedrini S"," Pelta-Heller J"," Chan T"," Yang Q"," Mao Z"," Sluzas E"," Gieringer T"," Ehrlich ME."],"journal":"The Journal of biological chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17209049","id":"17209049","citationCount":23},{"title":"Pitx3-transfected astrocytes secrete brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor and protect dopamine neurons in mesencephalon cultures.","authors":["Yang D"," Peng C"," Li X"," Fan X"," Li L"," Ming M"," Chen S"," Le W."],"journal":"Journal of neuroscience research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18646205","id":"18646205","citationCount":9},{"title":"Differential effects of classical and atypical antipsychotic drugs on rotenone-induced neurotoxicity in PC12 cells.","authors":["Tan QR"," Wang XZ"," Wang CY"," Liu XJ"," Chen YC"," Wang HH"," Zhang RG"," Zhen XC"," Tong Y"," Zhang ZJ."],"journal":"European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17442543","id":"17442543","citationCount":7}],"name":"BDNF","targetParticipants":[{"name":"BDNF","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dBDNF","idObject":0}]},{"targetElements":[],"references":[{"title":"Reactive oxygen species regulate ceruloplasmin by a novel mRNA decay mechanism involving its 3\u0027-untranslated region: implications in neurodegenerative diseases.","authors":["Tapryal N"," Mukhopadhyay C"," Das D"," Fox PL"," Mukhopadhyay CK."],"journal":"The Journal of biological chemistry","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19019832","id":"19019832","citationCount":13},{"title":"Increased vulnerability to rotenone-induced neurotoxicity in ceruloplasmin-deficient mice.","authors":["Kaneko K"," Hineno A"," Yoshida K"," Ikeda S."],"journal":"Neuroscience letters","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18804145","id":"18804145","citationCount":10}],"name":"CP","targetParticipants":[{"name":"CP","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dCP","idObject":0}]},{"targetElements":[],"references":[{"title":"RTP801 regulates maneb- and mancozeb-induced cytotoxicity via NF-κB.","authors":["Cheng SY"," Oh S"," Velasco M"," Ta C"," Montalvo J"," Calderone A."],"journal":"Journal of biochemical and molecular toxicology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24764117","id":"24764117","citationCount":1}],"name":"DDIT4","targetParticipants":[{"name":"DDIT4","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dDDIT4","idObject":0}]},{"targetElements":[],"references":[{"title":"Dopamine D₁ and D₂ receptor subtypes functional regulation in corpus striatum of unilateral rotenone lesioned Parkinson\u0027s rat model: effect of serotonin, dopamine and norepinephrine.","authors":["Paul J"," Nandhu MS"," Kuruvilla KP"," Paulose CS."],"journal":"Neurological research","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20887679","id":"20887679","citationCount":2}],"name":"DRD1","targetParticipants":[{"name":"DRD1","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dDRD1","idObject":0}]},{"targetElements":[],"references":[{"title":"Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats.","authors":["Lin CH"," Huang JY"," Ching CH"," Chuang JI."],"journal":"Journal of pineal research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","id":"18289173","citationCount":25},{"title":"Dopamine D₁ and D₂ receptor subtypes functional regulation in corpus striatum of unilateral rotenone lesioned Parkinson\u0027s rat model: effect of serotonin, dopamine and norepinephrine.","authors":["Paul J"," Nandhu MS"," Kuruvilla KP"," Paulose CS."],"journal":"Neurological research","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20887679","id":"20887679","citationCount":2}],"name":"DRD2","targetParticipants":[{"name":"DRD2","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dDRD2","idObject":0}]},{"targetElements":[],"references":[{"title":"Endothelin-1 production is enhanced by rotenone, a mitochondrial complex I inhibitor, in cultured rat cardiomyocytes.","authors":["Yuhki KI"," Miyauchi T"," Kakinuma Y"," Murakoshi N"," Maeda S"," Goto K"," Yamaguchi I"," Suzuki T."],"journal":"Journal of cardiovascular pharmacology","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11707688","id":"11707688","citationCount":7},{"title":"Mitochondrial dysfunction increases expression of endothelin-1 and induces apoptosis through caspase-3 activation in rat cardiomyocytes in vitro.","authors":["Yuki K"," Miyauchi T"," Kakinuma Y"," Murakoshi N"," Suzuki T"," Hayashi J"," Goto K"," Yamaguchi I."],"journal":"Journal of cardiovascular pharmacology","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11078378","id":"11078378","citationCount":5},{"title":"Mitochondrial ROS-K+ channel signaling pathway regulated secretion of human pulmonary artery endothelial cells.","authors":["Ouyang JS"," Li YP"," Li CY"," Cai C"," Chen CS"," Chen SX"," Chen YF"," Yang L"," Xie YP."],"journal":"Free radical research","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22928487","id":"22928487","citationCount":2}],"name":"EDN1","targetParticipants":[{"name":"EDN1","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dEDN1","idObject":0}]},{"targetElements":[],"references":[{"title":"Pitx3-transfected astrocytes secrete brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor and protect dopamine neurons in mesencephalon cultures.","authors":["Yang D"," Peng C"," Li X"," Fan X"," Li L"," Ming M"," Chen S"," Le W."],"journal":"Journal of neuroscience research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18646205","id":"18646205","citationCount":9}],"name":"GDNF","targetParticipants":[{"name":"GDNF","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dGDNF","idObject":0}]},{"targetElements":[],"references":[{"title":"Rotenone-induced neurotoxicity in rat brain areas: a study on neuronal and neuronal supportive cells.","authors":["Swarnkar S"," Goswami P"," Kamat PK"," Patro IK"," Singh S"," Nath C."],"journal":"Neuroscience","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23098804","id":"23098804","citationCount":4}],"name":"GFAP","targetParticipants":[{"name":"GFAP","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dGFAP","idObject":0}]},{"targetElements":[],"references":[{"title":"Microtubule: a common target for parkin and Parkinson\u0027s disease toxins.","authors":["Feng J."],"journal":"The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","id":"17079513","citationCount":28},{"title":"Standardized Hypericum perforatum reduces oxidative stress and increases gene expression of antioxidant enzymes on rotenone-exposed rats.","authors":["Sánchez-Reus MI"," Gómez del Rio MA"," Iglesias I"," Elorza M"," Slowing K"," Benedí J."],"journal":"Neuropharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","id":"17070561","citationCount":17},{"title":"The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.","authors":["Panee J"," Liu W"," Nakamura K"," Berry MJ."],"journal":"International journal of biological sciences","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":"17657281","citationCount":10},{"title":"Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine.","authors":["Molina-Jiménez MF"," Sánchez-Reus MI"," Cascales M"," Andrés D"," Benedí J."],"journal":"Toxicology and applied pharmacology","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15904944","id":"15904944","citationCount":9}],"name":"GPX1","targetParticipants":[{"name":"GPX1","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dGPX1","idObject":0}]},{"targetElements":[],"references":[{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":3}],"name":"GSTA4","targetParticipants":[{"name":"GSTA4","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dGSTA4","idObject":0}]},{"targetElements":[],"references":[{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":3}],"name":"GSTM1","targetParticipants":[{"name":"GSTM1","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dGSTM1","idObject":0}]},{"targetElements":[],"references":[{"title":"Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells.","authors":["Han Z"," Varadharaj S"," Giedt RJ"," Zweier JL"," Szeto HH"," Alevriadou BR."],"journal":"The Journal of pharmacology and experimental therapeutics","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19131585","id":"19131585","citationCount":28},{"title":"Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screening.","authors":["Coe KJ"," Jia Y"," Ho HK"," Rademacher P"," Bammler TK"," Beyer RP"," Farin FM"," Woodke L"," Plymate SR"," Fausto N"," Nelson SD."],"journal":"Chemical research in toxicology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17702527","id":"17702527","citationCount":19},{"title":"Cadmium-induced apoptosis in the BJAB human B cell line: involvement of PKC/ERK1/2/JNK signaling pathways in HO-1 expression.","authors":["Nemmiche S"," Chabane-Sari D"," Kadri M"," Guiraud P."],"journal":"Toxicology","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22659318","id":"22659318","citationCount":11},{"title":"Resveratrol partially prevents rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through induction of heme oxygenase-1 dependent autophagy.","authors":["Lin TK"," Chen SD"," Chuang YC"," Lin HY"," Huang CR"," Chuang JH"," Wang PW"," Huang ST"," Tiao MM"," Chen JB"," Liou CW."],"journal":"International journal of molecular sciences","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24451142","id":"24451142","citationCount":11},{"title":"The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.","authors":["Panee J"," Liu W"," Nakamura K"," Berry MJ."],"journal":"International journal of biological sciences","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":"17657281","citationCount":10},{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":3},{"title":"Pyrroloquinoline quinone-conferred neuroprotection in rotenone models of Parkinson\u0027s disease.","authors":["Qin J"," Wu M"," Yu S"," Gao X"," Zhang J"," Dong X"," Ji J"," Zhang Y"," Zhou L"," Zhang Q"," Ding F."],"journal":"Toxicology letters","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26276080","id":"26276080","citationCount":0}],"name":"HMOX1","targetParticipants":[{"name":"HMOX1","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dHMOX1","idObject":0}]},{"targetElements":[],"references":[{"title":"Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease.","authors":["Jin J"," Hulette C"," Wang Y"," Zhang T"," Pan C"," Wadhwa R"," Zhang J."],"journal":"Molecular \u0026 cellular proteomics : MCP","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16565515","id":"16565515","citationCount":85},{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":3}],"name":"HSPA9","targetParticipants":[{"name":"HSPA9","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dHSPA9","idObject":0}]},{"targetElements":[],"references":[{"title":"Role of mitochondrial oxidant generation in endothelial cell responses to hypoxia.","authors":["Pearlstein DP"," Ali MH"," Mungai PT"," Hynes KL"," Gewertz BL"," Schumacker PT."],"journal":"Arteriosclerosis, thrombosis, and vascular biology","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11950692","id":"11950692","citationCount":44},{"title":"Albumin-bound fatty acids induce mitochondrial oxidant stress and impair antioxidant responses in proximal tubular cells.","authors":["Ishola DA Jr"," Post JA"," van Timmeren MM"," Bakker SJ"," Goldschmeding R"," Koomans HA"," Braam B"," Joles JA."],"journal":"Kidney international","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16837928","id":"16837928","citationCount":23},{"title":"Inverse gene expression patterns for macrophage activating hepatotoxicants and peroxisome proliferators in rat liver.","authors":["McMillian M"," Nie AY"," Parker JB"," Leone A"," Kemmerer M"," Bryant S"," Herlich J"," Yieh L"," Bittner A"," Liu X"," Wan J"," Johnson MD."],"journal":"Biochemical pharmacology","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15135310","id":"15135310","citationCount":21},{"title":"Environmental toxicants inhibit neuronal Jak tyrosine kinase by mitochondrial disruption.","authors":["Monroe RK"," Halvorsen SW."],"journal":"Neurotoxicology","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19635391","id":"19635391","citationCount":13},{"title":"Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat.","authors":["Paulus P"," Ockelmann P"," Tacke S"," Karnowski N"," Ellinghaus P"," Scheller B"," Holfeld J"," Urbschat A"," Zacharowski K."],"journal":"PloS one","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22745725","id":"22745725","citationCount":7},{"title":"Rotenone, a mitochondrial respiratory complex I inhibitor, ameliorates lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice.","authors":["Ai Q"," Jing Y"," Jiang R"," Lin L"," Dai J"," Che Q"," Zhou D"," Jia M"," Wan J"," Zhang L."],"journal":"International immunopharmacology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24830863","id":"24830863","citationCount":4},{"title":"Reactive oxygen species regulate context-dependent inhibition of NFAT5 target genes.","authors":["Kim NH"," Hong BK"," Choi SY"," Moo Kwon H"," Cho CS"," Yi EC"," Kim WU."],"journal":"Experimental \u0026 molecular medicine","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23867654","id":"23867654","citationCount":3}],"name":"IL6","targetParticipants":[{"name":"IL6","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dIL6","idObject":0}]},{"targetElements":[],"references":[{"title":"Overexpression of Kir2.3 in PC12 cells resists rotenone-induced neurotoxicity associated with PKC signaling pathway.","authors":["Wang G"," Zeng J"," Shen CY"," Wang ZQ"," Chen SD."],"journal":"Biochemical and biophysical research communications","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18619942","id":"18619942","citationCount":3}],"name":"KCNJ4","targetParticipants":[{"name":"KCNJ4","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dKCNJ4","idObject":0}]},{"targetElements":[],"references":[{"title":"LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans.","authors":["Saha S"," Guillily MD"," Ferree A"," Lanceta J"," Chan D"," Ghosh J"," Hsu CH"," Segal L"," Raghavan K"," Matsumoto K"," Hisamoto N"," Kuwahara T"," Iwatsubo T"," Moore L"," Goldstein L"," Cookson M"," Wolozin B."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19625511","id":"19625511","citationCount":86},{"title":"Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.","authors":["Ng CH"," Mok SZ"," Koh C"," Ouyang X"," Fivaz ML"," Tan EK"," Dawson VL"," Dawson TM"," Yu F"," Lim KL."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","id":"19741132","citationCount":78},{"title":"Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson\u0027s disease.","authors":["Venderova K"," Kabbach G"," Abdel-Messih E"," Zhang Y"," Parks RJ"," Imai Y"," Gehrke S"," Ngsee J"," Lavoie MJ"," Slack RS"," Rao Y"," Zhang Z"," Lu B"," Haque ME"," Park DS."],"journal":"Human molecular genetics","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19692353","id":"19692353","citationCount":65},{"title":"Investigating convergent actions of genes linked to familial Parkinson\u0027s disease.","authors":["Wolozin B"," Saha S"," Guillily M"," Ferree A"," Riley M."],"journal":"Neuro-degenerative diseases","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18322385","id":"18322385","citationCount":17}],"name":"LRRK2","targetParticipants":[{"name":"LRRK2","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dLRRK2","idObject":0}]},{"targetElements":[],"references":[{"title":"Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice.","authors":["Hsieh CC"," Papaconstantinou J."],"journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16449798","id":"16449798","citationCount":75}],"name":"MAP3K5","targetParticipants":[{"name":"MAP3K5","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dMAP3K5","idObject":0}]},{"targetElements":[],"references":[{"title":"The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy.","authors":["Höglinger GU"," Lannuzel A"," Khondiker ME"," Michel PP"," Duyckaerts C"," Féger J"," Champy P"," Prigent A"," Medja F"," Lombes A"," Oertel WH"," Ruberg M"," Hirsch EC."],"journal":"Journal of neurochemistry","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16219024","id":"16219024","citationCount":67},{"title":"Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.","authors":["Dickey CA"," Ash P"," Klosak N"," Lee WC"," Petrucelli L"," Hutton M"," Eckman CB."],"journal":"Molecular neurodegeneration","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16930453","id":"16930453","citationCount":12}],"name":"MAPT","targetParticipants":[{"name":"MAPT","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dMAPT","idObject":0}]},{"targetElements":[],"references":[{"title":"PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1.","authors":["Corona JC"," de Souza SC"," Duchen MR."],"journal":"Experimental neurology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24374061","id":"24374061","citationCount":4},{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":3}],"name":"NQO1","targetParticipants":[{"name":"NQO1","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dNQO1","idObject":0}]},{"targetElements":[],"references":[{"title":"DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.","authors":["Thomas KJ"," McCoy MK"," Blackinton J"," Beilina A"," van der Brug M"," Sandebring A"," Miller D"," Maric D"," Cedazo-Minguez A"," Cookson MR."],"journal":"Human molecular genetics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","id":"20940149","citationCount":108},{"title":"Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.","authors":["Ng CH"," Mok SZ"," Koh C"," Ouyang X"," Fivaz ML"," Tan EK"," Dawson VL"," Dawson TM"," Yu F"," Lim KL."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","id":"19741132","citationCount":78},{"title":"Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline.","authors":["Casarejos MJ"," Menéndez J"," Solano RM"," Rodríguez-Navarro JA"," García de Yébenes J"," Mena MA."],"journal":"Journal of neurochemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16573651","id":"16573651","citationCount":58},{"title":"Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities.","authors":["Wang C"," Lu R"," Ouyang X"," Ho MW"," Chia W"," Yu F"," Lim KL."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17687034","id":"17687034","citationCount":43},{"title":"ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons.","authors":["Joselin AP"," Hewitt SJ"," Callaghan SM"," Kim RH"," Chung YH"," Mak TW"," Shen J"," Slack RS"," Park DS."],"journal":"Human molecular genetics","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22872702","id":"22872702","citationCount":43},{"title":"Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells.","authors":["Rosen KM"," Veereshwarayya V"," Moussa CE"," Fu Q"," Goldberg MS"," Schlossmacher MG"," Shen J"," Querfurth HW."],"journal":"The Journal of biological chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16517603","id":"16517603","citationCount":41}],"name":"PARK2","targetParticipants":[{"name":"PARK2","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dPARK2","idObject":0}]},{"targetElements":[],"references":[{"title":"Intersecting pathways to neurodegeneration in Parkinson\u0027s disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system.","authors":["Betarbet R"," Canet-Aviles RM"," Sherer TB"," Mastroberardino PG"," McLendon C"," Kim JH"," Lund S"," Na HM"," Taylor G"," Bence NF"," Kopito R"," Seo BB"," Yagi T"," Yagi A"," Klinefelter G"," Cookson MR"," Greenamyre JT."],"journal":"Neurobiology of disease","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16439141","id":"16439141","citationCount":110},{"title":"DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.","authors":["Thomas KJ"," McCoy MK"," Blackinton J"," Beilina A"," van der Brug M"," Sandebring A"," Miller D"," Maric D"," Cedazo-Minguez A"," Cookson MR."],"journal":"Human molecular genetics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","id":"20940149","citationCount":108},{"title":"Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection.","authors":["Lev N"," Ickowicz D"," Melamed E"," Offen D."],"journal":"Neurotoxicology","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18377993","id":"18377993","citationCount":52},{"title":"Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.","authors":["Inden M"," Kitamura Y"," Takeuchi H"," Yanagida T"," Takata K"," Kobayashi Y"," Taniguchi T"," Yoshimoto K"," Kaneko M"," Okuma Y"," Taira T"," Ariga H"," Shimohama S."],"journal":"Journal of neurochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17459145","id":"17459145","citationCount":51},{"title":"Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson\u0027s disease.","authors":["Liu F"," Nguyen JL"," Hulleman JD"," Li L"," Rochet JC."],"journal":"Journal of neurochemistry","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18331584","id":"18331584","citationCount":41},{"title":"DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone.","authors":["Mullett SJ"," Hinkle DA."],"journal":"Neurobiology of disease","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18930142","id":"18930142","citationCount":32},{"title":"Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase.","authors":["Pisani A"," Martella G"," Tscherter A"," Costa C"," Mercuri NB"," Bernardi G"," Shen J"," Calabresi P."],"journal":"Neurobiology of disease","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16624565","id":"16624565","citationCount":19},{"title":"Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes.","authors":["Ashley AK"," Hanneman WH"," Katoh T"," Moreno JA"," Pollack A"," Tjalkens RB"," Legare ME."],"journal":"Toxicology letters","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19063952","id":"19063952","citationCount":13},{"title":"DJ-1 protects dopaminergic neurons against rotenone-induced apoptosis by enhancing ERK-dependent mitophagy.","authors":["Gao H"," Yang W"," Qi Z"," Lu L"," Duan C"," Zhao C"," Yang H."],"journal":"Journal of molecular biology","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22898350","id":"22898350","citationCount":13}],"name":"PARK7","targetParticipants":[{"name":"PARK7","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dPARK7","idObject":0}]},{"targetElements":[],"references":[{"title":"DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.","authors":["Thomas KJ"," McCoy MK"," Blackinton J"," Beilina A"," van der Brug M"," Sandebring A"," Miller D"," Maric D"," Cedazo-Minguez A"," Cookson MR."],"journal":"Human molecular genetics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","id":"20940149","citationCount":108},{"title":"Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.","authors":["Sandebring A"," Thomas KJ"," Beilina A"," van der Brug M"," Cleland MM"," Ahmad R"," Miller DW"," Zambrano I"," Cowburn RF"," Behbahani H"," Cedazo-Mínguez A"," Cookson MR."],"journal":"PloS one","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19492085","id":"19492085","citationCount":84},{"title":"Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y.","authors":["Deng H"," Jankovic J"," Guo Y"," Xie W"," Le W."],"journal":"Biochemical and biophysical research communications","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16226715","id":"16226715","citationCount":68},{"title":"PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons.","authors":["Wang HL"," Chou AH"," Wu AS"," Chen SY"," Weng YH"," Kao YC"," Yeh TH"," Chu PJ"," Lu CS."],"journal":"Biochimica et biophysica acta","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21421046","id":"21421046","citationCount":34},{"title":"α-Synuclein transgenic mice reveal compensatory increases in Parkinson\u0027s disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment.","authors":["George S"," Mok SS"," Nurjono M"," Ayton S"," Finkelstein DI"," Masters CL"," Li QX"," Culvenor JG."],"journal":"Journal of molecular neuroscience : MN","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20464527","id":"20464527","citationCount":11}],"name":"PINK1","targetParticipants":[{"name":"PINK1","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dPINK1","idObject":0}]},{"targetElements":[],"references":[{"title":"Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson\u0027s disease model.","authors":["Choi WS"," Palmiter RD"," Xia Z."],"journal":"The Journal of cell biology","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21383081","id":"21383081","citationCount":52},{"title":"Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism.","authors":["Sai Y"," Wu Q"," Le W"," Ye F"," Li Y"," Dong Z."],"journal":"Toxicology in vitro : an international journal published in association with BIBRA","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18579341","id":"18579341","citationCount":22},{"title":"JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death.","authors":["Choi WS"," Kim HW"," Xia Z."],"journal":"Toxicology","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25496994","id":"25496994","citationCount":1},{"title":"Pyrroloquinoline quinone-conferred neuroprotection in rotenone models of Parkinson\u0027s disease.","authors":["Qin J"," Wu M"," Yu S"," Gao X"," Zhang J"," Dong X"," Ji J"," Zhang Y"," Zhou L"," Zhang Q"," Ding F."],"journal":"Toxicology letters","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26276080","id":"26276080","citationCount":0}],"name":"SLC18A2","targetParticipants":[{"name":"SLC18A2","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dSLC18A2","idObject":0}]},{"targetElements":[],"references":[{"title":"Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats.","authors":["Lin CH"," Huang JY"," Ching CH"," Chuang JI."],"journal":"Journal of pineal research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","id":"18289173","citationCount":25},{"title":"Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism.","authors":["Sai Y"," Wu Q"," Le W"," Ye F"," Li Y"," Dong Z."],"journal":"Toxicology in vitro : an international journal published in association with BIBRA","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18579341","id":"18579341","citationCount":22},{"title":"The role of dopamine transporter in selective toxicity of manganese and rotenone.","authors":["Hirata Y"," Suzuno H"," Tsuruta T"," Oh-hashi K"," Kiuchi K."],"journal":"Toxicology","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18206288","id":"18206288","citationCount":3},{"title":"Neonatal exposure to lipopolysaccharide enhances accumulation of α-synuclein aggregation and dopamine transporter protein expression in the substantia nigra in responses to rotenone challenge in later life.","authors":["Tien LT"," Kaizaki A"," Pang Y"," Cai Z"," Bhatt AJ"," Fan LW."],"journal":"Toxicology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23567316","id":"23567316","citationCount":3}],"name":"SLC6A3","targetParticipants":[{"name":"SLC6A3","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dSLC6A3","idObject":0}]},{"targetElements":[],"references":[{"title":"Chronic systemic pesticide exposure reproduces features of Parkinson\u0027s disease.","authors":["Betarbet R"," Sherer TB"," MacKenzie G"," Garcia-Osuna M"," Panov AV"," Greenamyre JT."],"journal":"Nature neuroscience","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11100151","id":"11100151","citationCount":1095},{"title":"An in vitro model of Parkinson\u0027s disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.","authors":["Sherer TB"," Betarbet R"," Stout AK"," Lund S"," Baptista M"," Panov AV"," Cookson MR"," Greenamyre JT."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12177198","id":"12177198","citationCount":199},{"title":"Intersecting pathways to neurodegeneration in Parkinson\u0027s disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system.","authors":["Betarbet R"," Canet-Aviles RM"," Sherer TB"," Mastroberardino PG"," McLendon C"," Kim JH"," Lund S"," Na HM"," Taylor G"," Bence NF"," Kopito R"," Seo BB"," Yagi T"," Yagi A"," Klinefelter G"," Cookson MR"," Greenamyre JT."],"journal":"Neurobiology of disease","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16439141","id":"16439141","citationCount":110},{"title":"Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.","authors":["Ved R"," Saha S"," Westlund B"," Perier C"," Burnam L"," Sluder A"," Hoener M"," Rodrigues CM"," Alfonso A"," Steer C"," Liu L"," Przedborski S"," Wolozin B."],"journal":"The Journal of biological chemistry","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16239214","id":"16239214","citationCount":109},{"title":"Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson\u0027s disease.","authors":["Uversky VN"," Li J"," Fink AL."],"journal":"FEBS letters","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11445065","id":"11445065","citationCount":101},{"title":"The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy.","authors":["Höglinger GU"," Lannuzel A"," Khondiker ME"," Michel PP"," Duyckaerts C"," Féger J"," Champy P"," Prigent A"," Medja F"," Lombes A"," Oertel WH"," Ruberg M"," Hirsch EC."],"journal":"Journal of neurochemistry","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16219024","id":"16219024","citationCount":67},{"title":"Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein.","authors":["Yu WH"," Dorado B"," Figueroa HY"," Wang L"," Planel E"," Cookson MR"," Clark LN"," Duff KE."],"journal":"The American journal of pathology","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19628769","id":"19628769","citationCount":53},{"title":"Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.","authors":["Inden M"," Kitamura Y"," Takeuchi H"," Yanagida T"," Takata K"," Kobayashi Y"," Taniguchi T"," Yoshimoto K"," Kaneko M"," Okuma Y"," Taira T"," Ariga H"," Shimohama S."],"journal":"Journal of neurochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17459145","id":"17459145","citationCount":51},{"title":"Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells.","authors":["Shavali S"," Brown-Borg HM"," Ebadi M"," Porter J."],"journal":"Neuroscience letters","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18514418","id":"18514418","citationCount":50},{"title":"RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport.","authors":["Fountaine TM"," Wade-Martins R."],"journal":"Journal of neuroscience research","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17131421","id":"17131421","citationCount":47},{"title":"Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice.","authors":["Pan-Montojo F"," Schwarz M"," Winkler C"," Arnhold M"," O\u0027Sullivan GA"," Pal A"," Said J"," Marsico G"," Verbavatz JM"," Rodrigo-Angulo M"," Gille G"," Funk RH"," Reichmann H."],"journal":"Scientific reports","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23205266","id":"23205266","citationCount":40},{"title":"Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice.","authors":["Dalfó E"," Gómez-Isla T"," Rosa JL"," Nieto Bodelón M"," Cuadrado Tejedor M"," Barrachina M"," Ambrosio S"," Ferrer I."],"journal":"Journal of neuropathology and experimental neurology","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15099020","id":"15099020","citationCount":35},{"title":"Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson\u0027s disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells.","authors":["Borland MK"," Trimmer PA"," Rubinstein JD"," Keeney PM"," Mohanakumar K"," Liu L"," Bennett JP Jr."],"journal":"Molecular neurodegeneration","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19114014","id":"19114014","citationCount":33},{"title":"Valproic acid is neuroprotective in the rotenone rat model of Parkinson\u0027s disease: involvement of alpha-synuclein.","authors":["Monti B"," Gatta V"," Piretti F"," Raffaelli SS"," Virgili M"," Contestabile A."],"journal":"Neurotoxicity research","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19626387","id":"19626387","citationCount":33},{"title":"Isogenic human iPSC Parkinson\u0027s model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.","authors":["Ryan SD"," Dolatabadi N"," Chan SF"," Zhang X"," Akhtar MW"," Parker J"," Soldner F"," Sunico CR"," Nagar S"," Talantova M"," Lee B"," Lopez K"," Nutter A"," Shan B"," Molokanova E"," Zhang Y"," Han X"," Nakamura T"," Masliah E"," Yates JR 3rd"," Nakanishi N"," Andreyev AY"," Okamoto S"," Jaenisch R"," Ambasudhan R"," Lipton SA."],"journal":"Cell","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24290359","id":"24290359","citationCount":27},{"title":"Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats.","authors":["Lin CH"," Huang JY"," Ching CH"," Chuang JI."],"journal":"Journal of pineal research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","id":"18289173","citationCount":25},{"title":"1-Benzyl-1,2,3,4-tetrahydroisoquinoline, a Parkinsonism-inducing endogenous toxin, increases alpha-synuclein expression and causes nuclear damage in human dopaminergic cells.","authors":["Shavali S"," Carlson EC"," Swinscoe JC"," Ebadi M."],"journal":"Journal of neuroscience research","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15114628","id":"15114628","citationCount":21},{"title":"Oxidants induce alternative splicing of alpha-synuclein: Implications for Parkinson\u0027s disease.","authors":["Kalivendi SV"," Yedlapudi D"," Hillard CJ"," Kalyanaraman B."],"journal":"Free radical biology \u0026 medicine","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19857570","id":"19857570","citationCount":20},{"title":"Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson\u0027s disease.","authors":["Zhang H"," Jia H"," Liu J"," Ao N"," Yan B"," Shen W"," Wang X"," Li X"," Luo C"," Liu J."],"journal":"Journal of cellular and molecular medicine","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20414966","id":"20414966","citationCount":20},{"title":"Rotenone induces apoptosis via activation of bad in human dopaminergic SH-SY5Y cells.","authors":["Watabe M"," Nakaki T."],"journal":"The Journal of pharmacology and experimental therapeutics","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15280438","id":"15280438","citationCount":20},{"title":"Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro.","authors":["Lehmensiek V"," Tan EM"," Schwarz J"," Storch A."],"journal":"Neuroreport","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12151787","id":"12151787","citationCount":11},{"title":"Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson\u0027s disease features and enhances vulnerability to mitochondrial impairment.","authors":["Cannon JR"," Geghman KD"," Tapias V"," Sew T"," Dail MK"," Li C"," Greenamyre JT."],"journal":"Experimental neurology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23153578","id":"23153578","citationCount":11},{"title":"α-Synuclein transgenic mice reveal compensatory increases in Parkinson\u0027s disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment.","authors":["George S"," Mok SS"," Nurjono M"," Ayton S"," Finkelstein DI"," Masters CL"," Li QX"," Culvenor JG."],"journal":"Journal of molecular neuroscience : MN","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20464527","id":"20464527","citationCount":11},{"title":"alpha-Synuclein redistributed and aggregated in rotenone-induced Parkinson\u0027s disease rats.","authors":["Feng Y"," Liang ZH"," Wang T"," Qiao X"," Liu HJ"," Sun SG."],"journal":"Neuroscience bulletin","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17690729","id":"17690729","citationCount":8},{"title":"Specific pesticide-dependent increases in α-synuclein levels in human neuroblastoma (SH-SY5Y) and melanoma (SK-MEL-2) cell lines.","authors":["Chorfa A"," Bétemps D"," Morignat E"," Lazizzera C"," Hogeveen K"," Andrieu T"," Baron T."],"journal":"Toxicological sciences : an official journal of the Society of Toxicology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23535362","id":"23535362","citationCount":8},{"title":"Rotenone upregulates alpha-synuclein and myocyte enhancer factor 2D independently from lysosomal degradation inhibition.","authors":["Sala G"," Arosio A"," Stefanoni G"," Melchionda L"," Riva C"," Marinig D"," Brighina L"," Ferrarese C."],"journal":"BioMed research international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23984410","id":"23984410","citationCount":5},{"title":"Environmental toxicants as extrinsic epigenetic factors for parkinsonism: studies employing transgenic C. elegans model.","authors":["Jadiya P"," Nazir A."],"journal":"CNS \u0026 neurological disorders drug targets","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23244436","id":"23244436","citationCount":5},{"title":"Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation.","authors":["Hou YS"," Guan JJ"," Xu HD"," Wu F"," Sheng R"," Qin ZH."],"journal":"Molecular and cellular biology","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26031332","id":"26031332","citationCount":2},{"title":"Rotenone down-regulates HSPA8/hsc70 chaperone protein in vitro: A new possible toxic mechanism contributing to Parkinson\u0027s disease.","authors":["Sala G"," Marinig D"," Riva C"," Arosio A"," Stefanoni G"," Brighina L"," Formenti M"," Alberghina L"," Colangelo AM"," Ferrarese C."],"journal":"Neurotoxicology","year":2016,"link":"http://www.ncbi.nlm.nih.gov/pubmed/27133439","id":"27133439","citationCount":1},{"title":"shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson\u0027s disease model.","authors":["Zharikov AD"," Cannon JR"," Tapias V"," Bai Q"," Horowitz MP"," Shah V"," El Ayadi A"," Hastings TG"," Greenamyre JT"," Burton EA."],"journal":"The Journal of clinical investigation","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26075822","id":"26075822","citationCount":1},{"title":"The molecular mechanism of rotenone-induced α-synuclein aggregation: emphasizing the role of the calcium/GSK3β pathway.","authors":["Yuan YH"," Yan WF"," Sun JD"," Huang JY"," Mu Z"," Chen NH."],"journal":"Toxicology letters","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25433145","id":"25433145","citationCount":1},{"title":"[Overexpression of alpha-synuclein in SH-SY5Y cells partially protected against oxidative stress induced by rotenone].","authors":["Liu YY"," Zhao HY"," Zhao CL"," Duan CL"," Lu LL"," Yang H."],"journal":"Sheng li xue bao : [Acta physiologica Sinica]","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17041725","id":"17041725","citationCount":0},{"title":"14-3-3 Proteins in the regulation of rotenone-induced neurotoxicity might be via its isoform 14-3-3epsilon\u0027s involvement in autophagy.","authors":["Sai Y"," Peng K"," Ye F"," Zhao X"," Zhao Y"," Zou Z"," Cao J"," Dong Z."],"journal":"Cellular and molecular neurobiology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24002177","id":"24002177","citationCount":0},{"title":"Daily rhythms of serotonin metabolism and the expression of clock genes in suprachiasmatic nucleus of rotenone-induced Parkinson\u0027s disease male Wistar rat model and effect of melatonin administration.","authors":["Mattam U"," Jagota A."],"journal":"Biogerontology","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25430725","id":"25430725","citationCount":0}],"name":"SNCA","targetParticipants":[{"name":"SNCA","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dSNCA","idObject":0}]},{"targetElements":[],"references":[{"title":"Microtubule: a common target for parkin and Parkinson\u0027s disease toxins.","authors":["Feng J."],"journal":"The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","id":"17079513","citationCount":28},{"title":"Standardized Hypericum perforatum reduces oxidative stress and increases gene expression of antioxidant enzymes on rotenone-exposed rats.","authors":["Sánchez-Reus MI"," Gómez del Rio MA"," Iglesias I"," Elorza M"," Slowing K"," Benedí J."],"journal":"Neuropharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","id":"17070561","citationCount":17},{"title":"The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.","authors":["Panee J"," Liu W"," Nakamura K"," Berry MJ."],"journal":"International journal of biological sciences","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":"17657281","citationCount":10},{"title":"An effective novel delivery strategy of rasagiline for Parkinson\u0027s disease.","authors":["Fernández M"," Negro S"," Slowing K"," Fernández-Carballido A"," Barcia E."],"journal":"International journal of pharmaceutics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","id":"21807080","citationCount":6},{"title":"PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1.","authors":["Corona JC"," de Souza SC"," Duchen MR."],"journal":"Experimental neurology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24374061","id":"24374061","citationCount":4},{"title":"Molecular responses differ between sensitive silver carp and tolerant bighead carp and bigmouth buffalo exposed to rotenone.","authors":["Amberg JJ"," Schreier TM"," Gaikowski MP."],"journal":"Fish physiology and biochemistry","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22447502","id":"22447502","citationCount":1}],"name":"SOD1","targetParticipants":[{"name":"SOD1","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dSOD1","idObject":0}]},{"targetElements":[],"references":[{"title":"Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species.","authors":["Chen Y"," McMillan-Ward E"," Kong J"," Israels SJ"," Gibson SB."],"journal":"Journal of cell science","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18032788","id":"18032788","citationCount":146},{"title":"Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress.","authors":["Hu Y"," Rosen DG"," Zhou Y"," Feng L"," Yang G"," Liu J"," Huang P."],"journal":"The Journal of biological chemistry","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16179351","id":"16179351","citationCount":80},{"title":"Overexpression of manganese superoxide dismutase protects against mitochondrial-initiated poly(ADP-ribose) polymerase-mediated cell death.","authors":["Kiningham KK"," Oberley TD"," Lin S"," Mattingly CA"," St Clair DK."],"journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10463952","id":"10463952","citationCount":36},{"title":"Microtubule: a common target for parkin and Parkinson\u0027s disease toxins.","authors":["Feng J."],"journal":"The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","id":"17079513","citationCount":28},{"title":"Standardized Hypericum perforatum reduces oxidative stress and increases gene expression of antioxidant enzymes on rotenone-exposed rats.","authors":["Sánchez-Reus MI"," Gómez del Rio MA"," Iglesias I"," Elorza M"," Slowing K"," Benedí J."],"journal":"Neuropharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","id":"17070561","citationCount":17},{"title":"The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.","authors":["Panee J"," Liu W"," Nakamura K"," Berry MJ."],"journal":"International journal of biological sciences","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":"17657281","citationCount":10},{"title":"Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine.","authors":["Molina-Jiménez MF"," Sánchez-Reus MI"," Cascales M"," Andrés D"," Benedí J."],"journal":"Toxicology and applied pharmacology","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15904944","id":"15904944","citationCount":9},{"title":"Enhanced metallothionein gene expression induced by mitochondrial oxidative stress is reduced in phospholipid hydroperoxide glutathione peroxidase-overexpressed cells.","authors":["Kadota Y"," Suzuki S"," Ideta S"," Fukinbara Y"," Kawakami T"," Imai H"," Nakagawa Y"," Sato M."],"journal":"European journal of pharmacology","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19818760","id":"19818760","citationCount":7},{"title":"Increased manganese superoxide dismutase activity, protein, and mRNA levels and concurrent induction of tumor necrosis factor alpha in radiation-initiated Syrian hamster cells.","authors":["Otero G"," Avila MA"," Emfietzoglou D"," Clerch LB"," Massaro D"," Notario V."],"journal":"Molecular carcinogenesis","year":1996,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8989910","id":"8989910","citationCount":6},{"title":"An effective novel delivery strategy of rasagiline for Parkinson\u0027s disease.","authors":["Fernández M"," Negro S"," Slowing K"," Fernández-Carballido A"," Barcia E."],"journal":"International journal of pharmaceutics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","id":"21807080","citationCount":6},{"title":"Molecular responses differ between sensitive silver carp and tolerant bighead carp and bigmouth buffalo exposed to rotenone.","authors":["Amberg JJ"," Schreier TM"," Gaikowski MP."],"journal":"Fish physiology and biochemistry","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22447502","id":"22447502","citationCount":1},{"title":"Pyrroloquinoline quinone (PQQ) producing Escherichia coli Nissle 1917 (EcN) alleviates age associated oxidative stress and hyperlipidemia, and improves mitochondrial function in ageing rats.","authors":["Singh AK"," Pandey SK"," Saha G"," Gattupalli NK."],"journal":"Experimental gerontology","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25843018","id":"25843018","citationCount":0}],"name":"SOD2","targetParticipants":[{"name":"SOD2","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dSOD2","idObject":0}]},{"targetElements":[],"references":[{"title":"Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin.","authors":["Chandel NS"," Trzyna WC"," McClintock DS"," Schumacker PT."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10878378","id":"10878378","citationCount":117},{"title":"Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by reactive oxygen species.","authors":["Deshpande SS"," Angkeow P"," Huang J"," Ozaki M"," Irani K."],"journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10973919","id":"10973919","citationCount":82},{"title":"Iptakalim alleviates rotenone-induced degeneration of dopaminergic neurons through inhibiting microglia-mediated neuroinflammation.","authors":["Zhou F"," Wu JY"," Sun XL"," Yao HH"," Ding JH"," Hu G."],"journal":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17356569","id":"17356569","citationCount":25},{"title":"Opening of microglial K(ATP) channels inhibits rotenone-induced neuroinflammation.","authors":["Zhou F"," Yao HH"," Wu JY"," Ding JH"," Sun T"," Hu G."],"journal":"Journal of cellular and molecular medicine","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19012619","id":"19012619","citationCount":25},{"title":"Regulation of hepatic nitric oxide synthase by reactive oxygen intermediates and glutathione.","authors":["Duval DL"," Sieg DJ"," Billings RE."],"journal":"Archives of biochemistry and biophysics","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7532384","id":"7532384","citationCount":23},{"title":"Inverse gene expression patterns for macrophage activating hepatotoxicants and peroxisome proliferators in rat liver.","authors":["McMillian M"," Nie AY"," Parker JB"," Leone A"," Kemmerer M"," Bryant S"," Herlich J"," Yieh L"," Bittner A"," Liu X"," Wan J"," Johnson MD."],"journal":"Biochemical pharmacology","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15135310","id":"15135310","citationCount":21},{"title":"Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.","authors":["Nair AS"," Shishodia S"," Ahn KS"," Kunnumakkara AB"," Sethi G"," Aggarwal BB."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17015749","id":"17015749","citationCount":18},{"title":"The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells.","authors":["Liu X"," Wu JY"," Zhou F"," Sun XL"," Yao HH"," Yang Y"," Ding JH"," Hu G."],"journal":"Neuroscience letters","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16257489","id":"16257489","citationCount":15},{"title":"Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice.","authors":["Kang HW"," Kim JM"," Cha MY"," Jung HC"," Song IS"," Kim JS."],"journal":"Digestive diseases and sciences","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22623043","id":"22623043","citationCount":12},{"title":"Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression.","authors":["Dat NT"," Lee JH"," Lee K"," Hong YS"," Kim YH"," Lee JJ."],"journal":"Journal of natural products","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18841906","id":"18841906","citationCount":12},{"title":"Rotenone, a mitochondrial electron transport inhibitor, ameliorates ischemia-reperfusion-induced intestinal mucosal damage in rats.","authors":["Ichikawa H"," Takagi T"," Uchiyama K"," Higashihara H"," Katada K"," Isozaki Y"," Naito Y"," Yoshida N"," Yoshikawa T."],"journal":"Redox report : communications in free radical research","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15720824","id":"15720824","citationCount":7},{"title":"An effective novel delivery strategy of rasagiline for Parkinson\u0027s disease.","authors":["Fernández M"," Negro S"," Slowing K"," Fernández-Carballido A"," Barcia E."],"journal":"International journal of pharmaceutics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","id":"21807080","citationCount":6},{"title":"Rotenone could activate microglia through NFκB associated pathway.","authors":["Yuan YH"," Sun JD"," Wu MM"," Hu JF"," Peng SY"," Chen NH."],"journal":"Neurochemical research","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23645222","id":"23645222","citationCount":6},{"title":"Rotenone, a mitochondrial respiratory complex I inhibitor, ameliorates lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice.","authors":["Ai Q"," Jing Y"," Jiang R"," Lin L"," Dai J"," Che Q"," Zhou D"," Jia M"," Wan J"," Zhang L."],"journal":"International immunopharmacology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24830863","id":"24830863","citationCount":4},{"title":"Resveratrol confers protection against rotenone-induced neurotoxicity by modulating myeloperoxidase levels in glial cells.","authors":["Chang CY"," Choi DK"," Lee DK"," Hong YJ"," Park EJ."],"journal":"PloS one","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23593274","id":"23593274","citationCount":4},{"title":"Neuroprotective effects of bee venom acupuncture therapy against rotenone-induced oxidative stress and apoptosis.","authors":["Khalil WK"," Assaf N"," ElShebiney SA"," Salem NA."],"journal":"Neurochemistry international","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25481089","id":"25481089","citationCount":3},{"title":"Downregulation of cystathionine β-synthase/hydrogen sulfide contributes to rotenone-induced microglia polarization toward M1 type.","authors":["Du C"," Jin M"," Hong Y"," Li Q"," Wang XH"," Xu JM"," Wang F"," Zhang Y"," Jia J"," Liu CF"," Hu LF."],"journal":"Biochemical and biophysical research communications","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25086357","id":"25086357","citationCount":2}],"name":"TNF","targetParticipants":[{"name":"TNF","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match\u003dTNF","idObject":0}]}]}]
\ No newline at end of file
diff --git a/frontend-js/testFiles/apiCalls/chemical/getChemicalsByTarget/columns=name&projectId=sample&targetId=329170&targetType=ALIAS&token=MOCK_TOKEN_ID& b/frontend-js/testFiles/apiCalls/chemical/getChemicalsByTarget/columns=name&projectId=sample&targetId=329170&targetType=ALIAS&token=MOCK_TOKEN_ID&
new file mode 100644
index 0000000000000000000000000000000000000000..0637a088a01e8ddab3bf3fa98dbe804cbde1a0dc
--- /dev/null
+++ b/frontend-js/testFiles/apiCalls/chemical/getChemicalsByTarget/columns=name&projectId=sample&targetId=329170&targetType=ALIAS&token=MOCK_TOKEN_ID&
@@ -0,0 +1 @@
+[]
\ No newline at end of file