diff --git a/frontend-js/testFiles/apiCalls/configuration/token=MOCK_TOKEN_ID& b/frontend-js/testFiles/apiCalls/configuration/token=MOCK_TOKEN_ID&
index f66c080f3e001e44cf7f064352dee9612eacda15..925c69b3491583724d0843e14e3850ac72e114e3 100644
--- a/frontend-js/testFiles/apiCalls/configuration/token=MOCK_TOKEN_ID&
+++ b/frontend-js/testFiles/apiCalls/configuration/token=MOCK_TOKEN_ID&
@@ -1 +1 @@
-{"annotators":[{"className":"lcsb.mapviewer.annotation.services.annotators.BrendaAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"name":"BRENDA","parametersDefinitions":[],"url":"http://www.brenda-enzymes.org"},{"className":"lcsb.mapviewer.annotation.services.annotators.BiocompendiumAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"name":"Biocompendium","parametersDefinitions":[],"url":"http://biocompendium.embl.de/"},{"className":"lcsb.mapviewer.annotation.services.annotators.CazyAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"name":"CAZy","parametersDefinitions":[],"url":"http://commonchemistry.org"},{"className":"lcsb.mapviewer.annotation.services.annotators.ChebiAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Chemical"],"name":"Chebi","parametersDefinitions":[],"url":"http://www.ebi.ac.uk/chebi/"},{"className":"lcsb.mapviewer.annotation.services.annotators.UniprotAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"name":"Uniprot","parametersDefinitions":[],"url":"http://www.uniprot.org/"},{"className":"lcsb.mapviewer.annotation.services.annotators.GoAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Phenotype","lcsb.mapviewer.model.map.compartment.Compartment","lcsb.mapviewer.model.map.species.Complex"],"name":"Gene Ontology","parametersDefinitions":[],"url":"http://amigo.geneontology.org/amigo"},{"className":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Rna","lcsb.mapviewer.model.map.species.Gene"],"name":"HGNC","parametersDefinitions":[],"url":"http://www.genenames.org"},{"className":"lcsb.mapviewer.annotation.services.annotators.KeggAnnotator","description":"Annotations extracted from KEGG ENZYME Database based on species EC numbers. Annotation include relevant publications and homologous genes for given EC numbers.","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"name":"KEGG","parametersDefinitions":[{"name":"KEGG organism identifier","description":"Space-delimited list of organisms codes for which homologous genes (GENE section in the KEGG enzyme record) should be imported. Currently only ATH (Arabidopsis Thaliana) is supported.","type":"java.lang.String"}],"url":"http://www.genome.jp/kegg/"},{"className":"lcsb.mapviewer.annotation.services.annotators.PdbAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Rna","lcsb.mapviewer.model.map.species.Gene"],"name":"Protein Data Bank","parametersDefinitions":[],"url":"http://www.pdbe.org/"},{"className":"lcsb.mapviewer.annotation.services.annotators.ReconAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Chemical","lcsb.mapviewer.model.map.reaction.Reaction"],"name":"Recon annotator","parametersDefinitions":[],"url":"http://humanmetabolism.org/"},{"className":"lcsb.mapviewer.annotation.services.annotators.EntrezAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Rna","lcsb.mapviewer.model.map.species.Gene"],"name":"Entrez Gene","parametersDefinitions":[],"url":"http://www.ncbi.nlm.nih.gov/gene"},{"className":"lcsb.mapviewer.annotation.services.annotators.EnsemblAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Rna","lcsb.mapviewer.model.map.species.Gene"],"name":"Ensembl","parametersDefinitions":[],"url":"www.ensembl.org"},{"className":"lcsb.mapviewer.annotation.services.annotators.StitchAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.SimpleMolecule"],"name":"STITCH","parametersDefinitions":[],"url":"http://stitch.embl.de/"},{"className":"lcsb.mapviewer.annotation.services.annotators.StringAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"name":"STRING","parametersDefinitions":[],"url":"http://string-db.org/"},{"className":"lcsb.mapviewer.annotation.services.annotators.TairAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"name":"TAIR","parametersDefinitions":[],"url":"http://arabidopsis.org/index.jsp"}],"buildDate":"19/03/2018 13:30","elementTypes":[{"className":"lcsb.mapviewer.model.map.species.Degraded","name":"Degraded","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"className":"lcsb.mapviewer.model.map.compartment.LeftSquareCompartment","name":"Compartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"className":"lcsb.mapviewer.model.map.species.IonChannelProtein","name":"Protein","parentClass":"lcsb.mapviewer.model.map.species.Protein"},{"className":"lcsb.mapviewer.model.map.compartment.TopSquareCompartment","name":"Compartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"className":"lcsb.mapviewer.model.map.species.Ion","name":"Ion","parentClass":"lcsb.mapviewer.model.map.species.Chemical"},{"className":"lcsb.mapviewer.model.map.species.Species","name":"Species","parentClass":"lcsb.mapviewer.model.map.species.Element"},{"className":"lcsb.mapviewer.model.map.compartment.RightSquareCompartment","name":"Compartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"className":"lcsb.mapviewer.model.map.species.Drug","name":"Drug","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"className":"lcsb.mapviewer.model.map.species.Protein","name":"Protein","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"className":"lcsb.mapviewer.model.map.species.TruncatedProtein","name":"Protein","parentClass":"lcsb.mapviewer.model.map.species.Protein"},{"className":"lcsb.mapviewer.model.map.compartment.PathwayCompartment","name":"Compartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"className":"lcsb.mapviewer.model.map.compartment.BottomSquareCompartment","name":"Compartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"className":"lcsb.mapviewer.model.map.species.Rna","name":"RNA","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"className":"lcsb.mapviewer.model.map.species.Chemical","name":"Chemical","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"className":"lcsb.mapviewer.model.map.compartment.Compartment","name":"Compartment","parentClass":"lcsb.mapviewer.model.map.species.Element"},{"className":"lcsb.mapviewer.model.map.compartment.OvalCompartment","name":"Compartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"className":"lcsb.mapviewer.model.map.compartment.SquareCompartment","name":"Compartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"className":"lcsb.mapviewer.model.map.species.Unknown","name":"Unknown","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"className":"lcsb.mapviewer.model.map.species.Element","name":"Element","parentClass":"lcsb.mapviewer.model.map.BioEntity"},{"className":"lcsb.mapviewer.model.map.species.Phenotype","name":"Phenotype","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"className":"lcsb.mapviewer.model.map.species.Complex","name":"Complex","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"className":"lcsb.mapviewer.model.map.species.AntisenseRna","name":"Antisense RNA","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"className":"lcsb.mapviewer.model.map.species.ReceptorProtein","name":"Protein","parentClass":"lcsb.mapviewer.model.map.species.Protein"},{"className":"lcsb.mapviewer.model.map.species.SimpleMolecule","name":"Simple molecule","parentClass":"lcsb.mapviewer.model.map.species.Chemical"},{"className":"lcsb.mapviewer.model.map.species.GenericProtein","name":"Protein","parentClass":"lcsb.mapviewer.model.map.species.Protein"},{"className":"lcsb.mapviewer.model.map.species.Gene","name":"Gene","parentClass":"lcsb.mapviewer.model.map.species.Species"}],"gitHash":"9596d4193c3b15b21931d226839cdb66252a39d1","imageFormats":[{"extension":"png","handler":"lcsb.mapviewer.converter.graphics.PngImageGenerator","name":"PNG image"},{"extension":"pdf","handler":"lcsb.mapviewer.converter.graphics.PdfImageGenerator","name":"PDF"},{"extension":"svg","handler":"lcsb.mapviewer.converter.graphics.SvgImageGenerator","name":"SVG image"}],"mapTypes":[{"id":"DOWNSTREAM_TARGETS","name":"Downstream targets"},{"id":"PATHWAY","name":"Pathway"},{"id":"UNKNOWN","name":"Unknown"}],"miriamTypes":{"BRENDA":{"commonName":"BRENDA","homepage":"http://www.brenda-enzymes.org","registryIdentifier":"MIR:00100101","uris":["urn:miriam:brenda"]},"CAS":{"commonName":"Chemical Abstracts Service","homepage":"http://commonchemistry.org","registryIdentifier":"MIR:00000237","uris":["urn:miriam:cas"]},"CAZY":{"commonName":"CAZy","homepage":"http://commonchemistry.org","registryIdentifier":"MIR:00000195","uris":["urn:miriam:cazy"]},"CCDS":{"commonName":"Consensus CDS","homepage":"http://www.ncbi.nlm.nih.gov/CCDS/","registryIdentifier":"MIR:00000375","uris":["urn:miriam:ccds"]},"CHEBI":{"commonName":"Chebi","homepage":"http://www.ebi.ac.uk/chebi/","registryIdentifier":"MIR:00000002","uris":["urn:miriam:obo.chebi","urn:miriam:chebi"]},"CHEMBL_COMPOUND":{"commonName":"ChEMBL","homepage":"https://www.ebi.ac.uk/chembldb/","registryIdentifier":"MIR:00000084","uris":["urn:miriam:chembl.compound"]},"CHEMBL_TARGET":{"commonName":"ChEMBL target","homepage":"https://www.ebi.ac.uk/chembldb/","registryIdentifier":"MIR:00000085","uris":["urn:miriam:chembl.target"]},"CHEMSPIDER":{"commonName":"ChemSpider","homepage":"http://www.chemspider.com//","registryIdentifier":"MIR:00000138","uris":["urn:miriam:chemspider"]},"COG":{"commonName":"Clusters of Orthologous Groups","homepage":"https://www.ncbi.nlm.nih.gov/COG/","registryIdentifier":"MIR:00000296","uris":["urn:miriam:cogs"]},"DOI":{"commonName":"Digital Object Identifier","homepage":"http://www.doi.org/","registryIdentifier":"MIR:00000019","uris":["urn:miriam:doi"]},"DRUGBANK":{"commonName":"DrugBank","homepage":"http://www.drugbank.ca/","registryIdentifier":"MIR:00000102","uris":["urn:miriam:drugbank"]},"DRUGBANK_TARGET_V4":{"commonName":"DrugBank Target v4","homepage":"http://www.drugbank.ca/targets","registryIdentifier":"MIR:00000528","uris":["urn:miriam:drugbankv4.target"]},"EC":{"commonName":"Enzyme Nomenclature","homepage":"http://www.enzyme-database.org/","registryIdentifier":"MIR:00000004","uris":["urn:miriam:ec-code"]},"ENSEMBL":{"commonName":"Ensembl","homepage":"www.ensembl.org","registryIdentifier":"MIR:00000003","uris":["urn:miriam:ensembl"]},"ENSEMBL_PLANTS":{"commonName":"Ensembl Plants","homepage":"http://plants.ensembl.org/","registryIdentifier":"MIR:00000205","uris":["urn:miriam:ensembl.plant"]},"ENTREZ":{"commonName":"Entrez Gene","homepage":"http://www.ncbi.nlm.nih.gov/gene","registryIdentifier":"MIR:00000069","uris":["urn:miriam:ncbigene","urn:miriam:entrez.gene"]},"GO":{"commonName":"Gene Ontology","homepage":"http://amigo.geneontology.org/amigo","registryIdentifier":"MIR:00000022","uris":["urn:miriam:obo.go","urn:miriam:go"]},"HGNC":{"commonName":"HGNC","homepage":"http://www.genenames.org","registryIdentifier":"MIR:00000080","uris":["urn:miriam:hgnc"]},"HGNC_SYMBOL":{"commonName":"HGNC Symbol","homepage":"http://www.genenames.org","registryIdentifier":"MIR:00000362","uris":["urn:miriam:hgnc.symbol"]},"HMDB":{"commonName":"HMDB","homepage":"http://www.hmdb.ca/","registryIdentifier":"MIR:00000051","uris":["urn:miriam:hmdb"]},"INTERPRO":{"commonName":"InterPro","homepage":"http://www.ebi.ac.uk/interpro/","registryIdentifier":"MIR:00000011","uris":["urn:miriam:interpro"]},"KEGG_COMPOUND":{"commonName":"Kegg Compound","homepage":"http://www.genome.jp/kegg/ligand.html","registryIdentifier":"MIR:00000013","uris":["urn:miriam:kegg.compound"]},"KEGG_GENES":{"commonName":"Kegg Genes","homepage":"http://www.genome.jp/kegg/genes.html","registryIdentifier":"MIR:00000070","uris":["urn:miriam:kegg.genes","urn:miriam:kegg.genes:hsa"]},"KEGG_ORTHOLOGY":{"commonName":"KEGG Orthology","homepage":"http://www.genome.jp/kegg/ko.html","registryIdentifier":"MIR:00000116","uris":["urn:miriam:kegg.orthology"]},"KEGG_PATHWAY":{"commonName":"Kegg Pathway","homepage":"http://www.genome.jp/kegg/pathway.html","registryIdentifier":"MIR:00000012","uris":["urn:miriam:kegg.pathway"]},"KEGG_REACTION":{"commonName":"Kegg Reaction","homepage":"http://www.genome.jp/kegg/reaction/","registryIdentifier":"MIR:00000014","uris":["urn:miriam:kegg.reaction"]},"MESH_2012":{"commonName":"MeSH 2012","homepage":"http://www.nlm.nih.gov/mesh/","registryIdentifier":"MIR:00000270","uris":["urn:miriam:mesh.2012","urn:miriam:mesh"]},"MGD":{"commonName":"Mouse Genome Database","homepage":"http://www.informatics.jax.org/","registryIdentifier":"MIR:00000037","uris":["urn:miriam:mgd"]},"MIR_TAR_BASE_MATURE_SEQUENCE":{"commonName":"miRTarBase Mature Sequence Database","homepage":"http://mirtarbase.mbc.nctu.edu.tw/","registryIdentifier":"MIR:00100739","uris":["urn:miriam:mirtarbase"]},"MI_R_BASE_MATURE_SEQUENCE":{"commonName":"miRBase Mature Sequence Database","homepage":"http://www.mirbase.org/","registryIdentifier":"MIR:00000235","uris":["urn:miriam:mirbase.mature"]},"MI_R_BASE_SEQUENCE":{"commonName":"miRBase Sequence Database","homepage":"http://www.mirbase.org/","registryIdentifier":"MIR:00000078","uris":["urn:miriam:mirbase"]},"OMIM":{"commonName":"Online Mendelian Inheritance in Man","homepage":"http://omim.org/","registryIdentifier":"MIR:00000016","uris":["urn:miriam:omim"]},"PANTHER":{"commonName":"PANTHER Family","homepage":"http://www.pantherdb.org/","registryIdentifier":"MIR:00000060","uris":["urn:miriam:panther.family","urn:miriam:panther"]},"PDB":{"commonName":"Protein Data Bank","homepage":"http://www.pdbe.org/","registryIdentifier":"MIR:00000020","uris":["urn:miriam:pdb"]},"PFAM":{"commonName":"Protein Family Database","homepage":"http://pfam.xfam.org//","registryIdentifier":"MIR:00000028","uris":["urn:miriam:pfam"]},"PHARM":{"commonName":"PharmGKB Pathways","homepage":"http://www.pharmgkb.org/","registryIdentifier":"MIR:00000089","uris":["urn:miriam:pharmgkb.pathways"]},"PUBCHEM":{"commonName":"PubChem-compound","homepage":"http://pubchem.ncbi.nlm.nih.gov/","registryIdentifier":"MIR:00000034","uris":["urn:miriam:pubchem.compound"]},"PUBCHEM_SUBSTANCE":{"commonName":"PubChem-substance","homepage":"http://pubchem.ncbi.nlm.nih.gov/","registryIdentifier":"MIR:00000033","uris":["urn:miriam:pubchem.substance"]},"PUBMED":{"commonName":"PubMed","homepage":"http://www.ncbi.nlm.nih.gov/PubMed/","registryIdentifier":"MIR:00000015","uris":["urn:miriam:pubmed"]},"REACTOME":{"commonName":"Reactome","homepage":"http://www.reactome.org/","registryIdentifier":"MIR:00000018","uris":["urn:miriam:reactome"]},"REFSEQ":{"commonName":"RefSeq","homepage":"http://www.ncbi.nlm.nih.gov/projects/RefSeq/","registryIdentifier":"MIR:00000039","uris":["urn:miriam:refseq"]},"SGD":{"commonName":"Saccharomyces Genome Database","homepage":"http://www.yeastgenome.org/","registryIdentifier":"MIR:00000023","uris":["urn:miriam:sgd"]},"STITCH":{"commonName":"STITCH","homepage":"http://stitch.embl.de/","registryIdentifier":"MIR:00100343","uris":["urn:miriam:stitch"]},"STRING":{"commonName":"STRING","homepage":"http://string-db.org/","registryIdentifier":"MIR:00000265","uris":["urn:miriam:string"]},"TAIR_LOCUS":{"commonName":"TAIR Locus","homepage":"http://arabidopsis.org/index.jsp","registryIdentifier":"MIR:00000050","uris":["urn:miriam:tair.locus"]},"TAXONOMY":{"commonName":"Taxonomy","homepage":"http://www.ncbi.nlm.nih.gov/taxonomy/","registryIdentifier":"MIR:00000006","uris":["urn:miriam:taxonomy"]},"TOXICOGENOMIC_CHEMICAL":{"commonName":"Toxicogenomic Chemical","homepage":"http://ctdbase.org/","registryIdentifier":"MIR:00000098","uris":["urn:miriam:ctd.chemical"]},"UNIGENE":{"commonName":"UniGene","homepage":"http://www.ncbi.nlm.nih.gov/unigene","registryIdentifier":"MIR:00000346","uris":["urn:miriam:unigene"]},"UNIPROT":{"commonName":"Uniprot","homepage":"http://www.uniprot.org/","registryIdentifier":"MIR:00000005","uris":["urn:miriam:uniprot"]},"UNIPROT_ISOFORM":{"commonName":"UniProt Isoform","homepage":"http://www.uniprot.org/","registryIdentifier":"MIR:00000388","uris":["urn:miriam:uniprot.isoform"]},"UNKNOWN":{"commonName":"Unknown","homepage":null,"registryIdentifier":null,"uris":[]},"WIKIDATA":{"commonName":"Wikidata","homepage":"https://www.wikidata.org/","registryIdentifier":"MIR:00000549","uris":["urn:miriam:wikidata"]},"WIKIPATHWAYS":{"commonName":"WikiPathways","homepage":"http://www.wikipathways.org/","registryIdentifier":"MIR:00000076","uris":["urn:miriam:wikipathways"]},"WIKIPEDIA":{"commonName":"Wikipedia (English)","homepage":"http://en.wikipedia.org/wiki/Main_Page","registryIdentifier":"MIR:00000384","uris":["urn:miriam:wikipedia.en"]},"WORM_BASE":{"commonName":"WormBase","homepage":"http://wormbase.bio2rdf.org/fct","registryIdentifier":"MIR:00000027","uris":["urn:miriam:wormbase"]}},"modelFormats":[{"extension":"xml","handler":"lcsb.mapviewer.converter.model.celldesigner.CellDesignerXmlParser","name":"CellDesigner SBML"},{"extension":"sbgn","handler":"lcsb.mapviewer.converter.model.sbgnml.SbgnmlXmlConverter","name":"SBGN-ML"},{"extension":"xml","handler":"lcsb.mapviewer.converter.model.sbml.SbmlParser","name":"SBML"}],"modificationStateTypes":{"ACETYLATED":{"abbreviation":"Ac","commonName":"acetylated"},"DONT_CARE":{"abbreviation":"*","commonName":"don't care"},"EMPTY":{"abbreviation":"","commonName":"empty"},"GLYCOSYLATED":{"abbreviation":"G","commonName":"glycosylated"},"HYDROXYLATED":{"abbreviation":"OH","commonName":"hydroxylated"},"METHYLATED":{"abbreviation":"Me","commonName":"methylated"},"MYRISTOYLATED":{"abbreviation":"My","commonName":"myristoylated"},"PALMYTOYLATED":{"abbreviation":"Pa","commonName":"palmytoylated"},"PHOSPHORYLATED":{"abbreviation":"P","commonName":"phosphorylated"},"PRENYLATED":{"abbreviation":"Pr","commonName":"prenylated"},"PROTONATED":{"abbreviation":"H","commonName":"protonated"},"SULFATED":{"abbreviation":"S","commonName":"sulfated"},"UBIQUITINATED":{"abbreviation":"Ub","commonName":"ubiquitinated"},"UNKNOWN":{"abbreviation":"?","commonName":"unknown"}},"options":[{"idObject":9,"type":"EMAIL_ADDRESS","value":"gawron13@o2.pl","valueType":"EMAIL","commonName":"E-mail address"},{"idObject":10,"type":"EMAIL_LOGIN","value":"gawron13","valueType":"STRING","commonName":"E-mail server login"},{"idObject":11,"type":"EMAIL_PASSWORD","value":"k13liszk!","valueType":"PASSWORD","commonName":"E-mail server password"},{"idObject":13,"type":"EMAIL_IMAP_SERVER","value":"your.imap.domain.com","valueType":"STRING","commonName":"IMAP server"},{"idObject":12,"type":"EMAIL_SMTP_SERVER","value":"poczta.o2.pl","valueType":"STRING","commonName":"SMTP server"},{"idObject":14,"type":"EMAIL_SMTP_PORT","value":"25","valueType":"INTEGER","commonName":"SMTP port"},{"idObject":6,"type":"DEFAULT_MAP","value":"sample","valueType":"STRING","commonName":"Default Project Id"},{"idObject":4,"type":"LOGO_IMG","value":"udl.png","valueType":"URL","commonName":"Logo icon"},{"idObject":3,"type":"LOGO_LINK","value":"http://wwwen.uni.lu/","valueType":"URL","commonName":"Logo link (after click)"},{"idObject":7,"type":"SEARCH_DISTANCE","value":"10","valueType":"DOUBLE","commonName":"Max distance for clicking on element (px)"},{"idObject":1,"type":"REQUEST_ACCOUNT_EMAIL","value":"your.email@domain.com","valueType":"EMAIL","commonName":"Email used for requesting an account"},{"idObject":8,"type":"SEARCH_RESULT_NUMBER","value":"300","valueType":"INTEGER","commonName":"Max number of results in search box. "},{"idObject":2,"type":"GOOGLE_ANALYTICS_IDENTIFIER","value":"","valueType":"STRING","commonName":"Google Analytics tracking ID used for statistics"},{"idObject":5,"type":"LOGO_TEXT","value":"University of Luxembourg","valueType":"STRING","commonName":"Logo description"},{"idObject":56,"type":"X_FRAME_DOMAIN","value":"http://localhost:8080/","valueType":"URL","commonName":"Domain allowed to connect via x-frame technology"},{"idObject":131,"type":"BIG_FILE_STORAGE_DIR","value":"minerva-big/","valueType":"STRING","commonName":"Path to store big files"},{"idObject":138,"type":"LEGEND_FILE_1","value":"resources/images/legend_a.png","valueType":"URL","commonName":"Legend 1 image file"},{"idObject":139,"type":"LEGEND_FILE_2","value":"resources/images/legend_b.png","valueType":"URL","commonName":"Legend 2 image file"},{"idObject":140,"type":"LEGEND_FILE_3","value":"resources/images/legend_c.png","valueType":"URL","commonName":"Legend 3 image file"},{"idObject":141,"type":"LEGEND_FILE_4","value":"resources/images/legend_d.png","valueType":"URL","commonName":"Legend 4 image file"},{"idObject":142,"type":"USER_MANUAL_FILE","value":"resources/other/user_guide.pdf","valueType":"URL","commonName":"User manual file"},{"idObject":205,"type":"MIN_COLOR_VAL","value":"FF0000","valueType":"COLOR","commonName":"Overlay color for negative values"},{"idObject":206,"type":"MAX_COLOR_VAL","value":"fbff00","valueType":"COLOR","commonName":"Overlay color for postive values"},{"idObject":218,"type":"SIMPLE_COLOR_VAL","value":"00ff40","valueType":"COLOR","commonName":"Overlay color when no values are defined"},{"idObject":239,"type":"NEUTRAL_COLOR_VAL","value":"0400ff","valueType":"COLOR","commonName":"Overlay color for value=0"},{"idObject":252,"type":"OVERLAY_OPACITY","value":"0.8","valueType":"DOUBLE","commonName":"Opacity used when drwaing data overlays (value between 0.0-1.0)"},{"idObject":253,"type":"REQUEST_ACCOUNT_DEFAULT_CONTENT","value":"Dear Diseas map team,\n\nI would like to request for an account.\n\nKind regards","valueType":"TEXT","commonName":"Email content used for requesting an account"},{"idObject":266,"type":"DEFAULT_VIEW_PROJECT","value":"true","valueType":"BOOLEAN","commonName":"Default user privilege for: View project"},{"idObject":267,"type":"DEFAULT_EDIT_COMMENTS_PROJECT","value":"true","valueType":"BOOLEAN","commonName":"Default user privilege for: Manage comments"},{"idObject":268,"type":"DEFAULT_LAYOUT_MANAGEMENT","value":"false","valueType":"BOOLEAN","commonName":"Default user privilege for: Manage layouts"}],"overlayTypes":[{"name":"GENERIC"},{"name":"GENETIC_VARIANT"}],"plugins":[],"privilegeTypes":{"ADD_MAP":{"commonName":"Add project","objectType":null,"valueType":"boolean"},"CONFIGURATION_MANAGE":{"commonName":"Manage configuration","objectType":null,"valueType":"boolean"},"CUSTOM_LAYOUTS":{"commonName":"Custom layouts","objectType":null,"valueType":"int"},"EDIT_COMMENTS_PROJECT":{"commonName":"Manage comments","objectType":"Project","valueType":"boolean"},"LAYOUT_MANAGEMENT":{"commonName":"Manage layouts","objectType":"Project","valueType":"boolean"},"LAYOUT_VIEW":{"commonName":"View layout","objectType":"Layout","valueType":"boolean"},"MANAGE_GENOMES":{"commonName":"Manage genomes","objectType":null,"valueType":"boolean"},"PROJECT_MANAGEMENT":{"commonName":"Map management","objectType":null,"valueType":"boolean"},"USER_MANAGEMENT":{"commonName":"User management","objectType":null,"valueType":"boolean"},"VIEW_PROJECT":{"commonName":"View project","objectType":"Project","valueType":"boolean"}},"reactionTypes":[{"className":"lcsb.mapviewer.model.map.reaction.type.CatalysisReaction","name":"Catalysis","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.UnknownPositiveInfluenceReaction","name":"Unknown positive influence","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.Reaction","name":"Generic Reaction","parentClass":"lcsb.mapviewer.model.map.BioEntity"},{"className":"lcsb.mapviewer.model.map.reaction.type.KnownTransitionOmittedReaction","name":"Known transition omitted","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.ReducedModulationReaction","name":"Reduced modulation","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.TranslationReaction","name":"Translation","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.HeterodimerAssociationReaction","name":"Heterodimer association","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.TranscriptionReaction","name":"Transcription","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.UnknownReducedTriggerReaction","name":"Unknown reduced trigger","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.UnknownNegativeInfluenceReaction","name":"Unknown negative influence","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.TruncationReaction","name":"Truncation","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.TransportReaction","name":"Transport","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.UnknownCatalysisReaction","name":"Unknown catalysis","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.ReducedTriggerReaction","name":"Reduced trigger","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.StateTransitionReaction","name":"State transition","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.PhysicalStimulationReaction","name":"Physical stimulation","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.BooleanLogicGateReaction","name":"Boolean logic gate","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.DissociationReaction","name":"Dissociation","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.InhibitionReaction","name":"Inhibition","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.ReducedPhysicalStimulationReaction","name":"Reduced physical stimulation","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.NegativeInfluenceReaction","name":"Negative influence","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.UnknownInhibitionReaction","name":"Unknown inhibition","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.ModulationReaction","name":"Modulation","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.PositiveInfluenceReaction","name":"Positive influence","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.UnknownReducedPhysicalStimulationReaction","name":"Unknown reduced physical stimulation","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.UnknownReducedModulationReaction","name":"Unknown reduced modulation","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.UnknownTransitionReaction","name":"Unknown transition","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.TriggerReaction","name":"Trigger","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"}],"unitTypes":[{"id":"AMPERE","name":"ampere"},{"id":"BECQUEREL","name":"becquerel"},{"id":"CANDELA","name":"candela"},{"id":"COULUMB","name":"coulumb"},{"id":"DIMENSIONLESS","name":"dimensionless"},{"id":"FARAD","name":"farad"},{"id":"GRAM","name":"gram"},{"id":"GRAY","name":"gray"},{"id":"HENRY","name":"henry"},{"id":"HERTZ","name":"hertz"},{"id":"ITEM","name":"item"},{"id":"JOULE","name":"joule"},{"id":"KATAL","name":"katal"},{"id":"KELVIN","name":"kelvin"},{"id":"KILOGRAM","name":"kilogram"},{"id":"LITRE","name":"litre"},{"id":"LUMEN","name":"lumen"},{"id":"LUX","name":"lux"},{"id":"METRE","name":"metre"},{"id":"MOLE","name":"mole"},{"id":"NEWTON","name":"newton"},{"id":"OHM","name":"ohm"},{"id":"PASCAL","name":"pascal"},{"id":"RADIAN","name":"radian"},{"id":"SECOND","name":"second"},{"id":"SIEMENS","name":"siemens"},{"id":"SIEVERT","name":"sievert"},{"id":"STERADIAN","name":"steradian"},{"id":"TESLA","name":"tesla"},{"id":"VOLT","name":"volt"},{"id":"WATT","name":"watt"},{"id":"WEBER","name":"weber"}],"version":"12.0.0~alpha.1"}
\ No newline at end of file
+{"annotators":[{"className":"lcsb.mapviewer.annotation.services.annotators.BrendaAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"name":"BRENDA","parametersDefinitions":[],"url":"http://www.brenda-enzymes.org"},{"className":"lcsb.mapviewer.annotation.services.annotators.BiocompendiumAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"name":"Biocompendium","parametersDefinitions":[],"url":"http://biocompendium.embl.de/"},{"className":"lcsb.mapviewer.annotation.services.annotators.CazyAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"name":"CAZy","parametersDefinitions":[],"url":"http://commonchemistry.org"},{"className":"lcsb.mapviewer.annotation.services.annotators.ChebiAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Chemical"],"name":"Chebi","parametersDefinitions":[],"url":"http://www.ebi.ac.uk/chebi/"},{"className":"lcsb.mapviewer.annotation.services.annotators.UniprotAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"name":"Uniprot","parametersDefinitions":[],"url":"http://www.uniprot.org/"},{"className":"lcsb.mapviewer.annotation.services.annotators.GoAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Phenotype","lcsb.mapviewer.model.map.compartment.Compartment","lcsb.mapviewer.model.map.species.Complex"],"name":"Gene Ontology","parametersDefinitions":[],"url":"http://amigo.geneontology.org/amigo"},{"className":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Rna","lcsb.mapviewer.model.map.species.Gene"],"name":"HGNC","parametersDefinitions":[],"url":"http://www.genenames.org"},{"className":"lcsb.mapviewer.annotation.services.annotators.KeggAnnotator","description":"Annotations extracted from KEGG ENZYME Database based on species EC numbers. Annotation include relevant publications and homologous genes for given EC numbers.","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"name":"KEGG","parametersDefinitions":[{"name":"KEGG organism identifier","description":"Space-delimited list of organisms codes for which homologous genes (GENE section in the KEGG enzyme record) should be imported. Currently only ATH (Arabidopsis Thaliana) is supported.","type":"java.lang.String"}],"url":"http://www.genome.jp/kegg/"},{"className":"lcsb.mapviewer.annotation.services.annotators.PdbAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Rna","lcsb.mapviewer.model.map.species.Gene"],"name":"Protein Data Bank","parametersDefinitions":[],"url":"http://www.pdbe.org/"},{"className":"lcsb.mapviewer.annotation.services.annotators.ReconAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Chemical","lcsb.mapviewer.model.map.reaction.Reaction"],"name":"Recon annotator","parametersDefinitions":[],"url":"http://humanmetabolism.org/"},{"className":"lcsb.mapviewer.annotation.services.annotators.EntrezAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Rna","lcsb.mapviewer.model.map.species.Gene"],"name":"Entrez Gene","parametersDefinitions":[],"url":"http://www.ncbi.nlm.nih.gov/gene"},{"className":"lcsb.mapviewer.annotation.services.annotators.EnsemblAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Rna","lcsb.mapviewer.model.map.species.Gene"],"name":"Ensembl","parametersDefinitions":[],"url":"www.ensembl.org"},{"className":"lcsb.mapviewer.annotation.services.annotators.StitchAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.SimpleMolecule"],"name":"STITCH","parametersDefinitions":[],"url":"http://stitch.embl.de/"},{"className":"lcsb.mapviewer.annotation.services.annotators.StringAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"name":"STRING","parametersDefinitions":[],"url":"http://string-db.org/"},{"className":"lcsb.mapviewer.annotation.services.annotators.TairAnnotator","description":"","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"name":"TAIR","parametersDefinitions":[],"url":"http://arabidopsis.org/index.jsp"}],"buildDate":"19/03/2018 13:30","elementTypes":[{"className":"lcsb.mapviewer.model.map.species.Degraded","name":"Degraded","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"className":"lcsb.mapviewer.model.map.compartment.LeftSquareCompartment","name":"Compartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"className":"lcsb.mapviewer.model.map.species.IonChannelProtein","name":"Protein","parentClass":"lcsb.mapviewer.model.map.species.Protein"},{"className":"lcsb.mapviewer.model.map.compartment.TopSquareCompartment","name":"Compartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"className":"lcsb.mapviewer.model.map.species.Ion","name":"Ion","parentClass":"lcsb.mapviewer.model.map.species.Chemical"},{"className":"lcsb.mapviewer.model.map.species.Species","name":"Species","parentClass":"lcsb.mapviewer.model.map.species.Element"},{"className":"lcsb.mapviewer.model.map.compartment.RightSquareCompartment","name":"Compartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"className":"lcsb.mapviewer.model.map.species.Drug","name":"Drug","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"className":"lcsb.mapviewer.model.map.species.Protein","name":"Protein","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"className":"lcsb.mapviewer.model.map.species.TruncatedProtein","name":"Protein","parentClass":"lcsb.mapviewer.model.map.species.Protein"},{"className":"lcsb.mapviewer.model.map.compartment.PathwayCompartment","name":"Compartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"className":"lcsb.mapviewer.model.map.compartment.BottomSquareCompartment","name":"Compartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"className":"lcsb.mapviewer.model.map.species.Rna","name":"RNA","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"className":"lcsb.mapviewer.model.map.species.Chemical","name":"Chemical","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"className":"lcsb.mapviewer.model.map.compartment.Compartment","name":"Compartment","parentClass":"lcsb.mapviewer.model.map.species.Element"},{"className":"lcsb.mapviewer.model.map.compartment.OvalCompartment","name":"Compartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"className":"lcsb.mapviewer.model.map.compartment.SquareCompartment","name":"Compartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"className":"lcsb.mapviewer.model.map.species.Unknown","name":"Unknown","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"className":"lcsb.mapviewer.model.map.species.Element","name":"Element","parentClass":"lcsb.mapviewer.model.map.BioEntity"},{"className":"lcsb.mapviewer.model.map.species.Phenotype","name":"Phenotype","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"className":"lcsb.mapviewer.model.map.species.Complex","name":"Complex","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"className":"lcsb.mapviewer.model.map.species.AntisenseRna","name":"Antisense RNA","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"className":"lcsb.mapviewer.model.map.species.ReceptorProtein","name":"Protein","parentClass":"lcsb.mapviewer.model.map.species.Protein"},{"className":"lcsb.mapviewer.model.map.species.SimpleMolecule","name":"Simple molecule","parentClass":"lcsb.mapviewer.model.map.species.Chemical"},{"className":"lcsb.mapviewer.model.map.species.GenericProtein","name":"Protein","parentClass":"lcsb.mapviewer.model.map.species.Protein"},{"className":"lcsb.mapviewer.model.map.species.Gene","name":"Gene","parentClass":"lcsb.mapviewer.model.map.species.Species"}],"gitHash":"9596d4193c3b15b21931d226839cdb66252a39d1","imageFormats":[{"extension":"png","handler":"lcsb.mapviewer.converter.graphics.PngImageGenerator","name":"PNG image"},{"extension":"pdf","handler":"lcsb.mapviewer.converter.graphics.PdfImageGenerator","name":"PDF"},{"extension":"svg","handler":"lcsb.mapviewer.converter.graphics.SvgImageGenerator","name":"SVG image"}],"mapTypes":[{"id":"DOWNSTREAM_TARGETS","name":"Downstream targets"},{"id":"PATHWAY","name":"Pathway"},{"id":"UNKNOWN","name":"Unknown"}],"miriamTypes":{"BRENDA":{"commonName":"BRENDA","homepage":"http://www.brenda-enzymes.org","registryIdentifier":"MIR:00100101","uris":["urn:miriam:brenda"]},"CAS":{"commonName":"Chemical Abstracts Service","homepage":"http://commonchemistry.org","registryIdentifier":"MIR:00000237","uris":["urn:miriam:cas"]},"CAZY":{"commonName":"CAZy","homepage":"http://commonchemistry.org","registryIdentifier":"MIR:00000195","uris":["urn:miriam:cazy"]},"CCDS":{"commonName":"Consensus CDS","homepage":"http://www.ncbi.nlm.nih.gov/CCDS/","registryIdentifier":"MIR:00000375","uris":["urn:miriam:ccds"]},"CHEBI":{"commonName":"Chebi","homepage":"http://www.ebi.ac.uk/chebi/","registryIdentifier":"MIR:00000002","uris":["urn:miriam:obo.chebi","urn:miriam:chebi"]},"CHEMBL_COMPOUND":{"commonName":"ChEMBL","homepage":"https://www.ebi.ac.uk/chembldb/","registryIdentifier":"MIR:00000084","uris":["urn:miriam:chembl.compound"]},"CHEMBL_TARGET":{"commonName":"ChEMBL target","homepage":"https://www.ebi.ac.uk/chembldb/","registryIdentifier":"MIR:00000085","uris":["urn:miriam:chembl.target"]},"CHEMSPIDER":{"commonName":"ChemSpider","homepage":"http://www.chemspider.com//","registryIdentifier":"MIR:00000138","uris":["urn:miriam:chemspider"]},"COG":{"commonName":"Clusters of Orthologous Groups","homepage":"https://www.ncbi.nlm.nih.gov/COG/","registryIdentifier":"MIR:00000296","uris":["urn:miriam:cogs"]},"DOI":{"commonName":"Digital Object Identifier","homepage":"http://www.doi.org/","registryIdentifier":"MIR:00000019","uris":["urn:miriam:doi"]},"DRUGBANK":{"commonName":"DrugBank","homepage":"http://www.drugbank.ca/","registryIdentifier":"MIR:00000102","uris":["urn:miriam:drugbank"]},"DRUGBANK_TARGET_V4":{"commonName":"DrugBank Target v4","homepage":"http://www.drugbank.ca/targets","registryIdentifier":"MIR:00000528","uris":["urn:miriam:drugbankv4.target"]},"EC":{"commonName":"Enzyme Nomenclature","homepage":"http://www.enzyme-database.org/","registryIdentifier":"MIR:00000004","uris":["urn:miriam:ec-code"]},"ENSEMBL":{"commonName":"Ensembl","homepage":"www.ensembl.org","registryIdentifier":"MIR:00000003","uris":["urn:miriam:ensembl"]},"ENSEMBL_PLANTS":{"commonName":"Ensembl Plants","homepage":"http://plants.ensembl.org/","registryIdentifier":"MIR:00000205","uris":["urn:miriam:ensembl.plant"]},"ENTREZ":{"commonName":"Entrez Gene","homepage":"http://www.ncbi.nlm.nih.gov/gene","registryIdentifier":"MIR:00000069","uris":["urn:miriam:ncbigene","urn:miriam:entrez.gene"]},"GO":{"commonName":"Gene Ontology","homepage":"http://amigo.geneontology.org/amigo","registryIdentifier":"MIR:00000022","uris":["urn:miriam:obo.go","urn:miriam:go"]},"HGNC":{"commonName":"HGNC","homepage":"http://www.genenames.org","registryIdentifier":"MIR:00000080","uris":["urn:miriam:hgnc"]},"HGNC_SYMBOL":{"commonName":"HGNC Symbol","homepage":"http://www.genenames.org","registryIdentifier":"MIR:00000362","uris":["urn:miriam:hgnc.symbol"]},"HMDB":{"commonName":"HMDB","homepage":"http://www.hmdb.ca/","registryIdentifier":"MIR:00000051","uris":["urn:miriam:hmdb"]},"INTERPRO":{"commonName":"InterPro","homepage":"http://www.ebi.ac.uk/interpro/","registryIdentifier":"MIR:00000011","uris":["urn:miriam:interpro"]},"KEGG_COMPOUND":{"commonName":"Kegg Compound","homepage":"http://www.genome.jp/kegg/ligand.html","registryIdentifier":"MIR:00000013","uris":["urn:miriam:kegg.compound"]},"KEGG_GENES":{"commonName":"Kegg Genes","homepage":"http://www.genome.jp/kegg/genes.html","registryIdentifier":"MIR:00000070","uris":["urn:miriam:kegg.genes","urn:miriam:kegg.genes:hsa"]},"KEGG_ORTHOLOGY":{"commonName":"KEGG Orthology","homepage":"http://www.genome.jp/kegg/ko.html","registryIdentifier":"MIR:00000116","uris":["urn:miriam:kegg.orthology"]},"KEGG_PATHWAY":{"commonName":"Kegg Pathway","homepage":"http://www.genome.jp/kegg/pathway.html","registryIdentifier":"MIR:00000012","uris":["urn:miriam:kegg.pathway"]},"KEGG_REACTION":{"commonName":"Kegg Reaction","homepage":"http://www.genome.jp/kegg/reaction/","registryIdentifier":"MIR:00000014","uris":["urn:miriam:kegg.reaction"]},"MESH_2012":{"commonName":"MeSH 2012","homepage":"http://www.nlm.nih.gov/mesh/","registryIdentifier":"MIR:00000270","uris":["urn:miriam:mesh.2012","urn:miriam:mesh"]},"MGD":{"commonName":"Mouse Genome Database","homepage":"http://www.informatics.jax.org/","registryIdentifier":"MIR:00000037","uris":["urn:miriam:mgd"]},"MIR_TAR_BASE_MATURE_SEQUENCE":{"commonName":"miRTarBase Mature Sequence Database","homepage":"http://mirtarbase.mbc.nctu.edu.tw/","registryIdentifier":"MIR:00100739","uris":["urn:miriam:mirtarbase"]},"MI_R_BASE_MATURE_SEQUENCE":{"commonName":"miRBase Mature Sequence Database","homepage":"http://www.mirbase.org/","registryIdentifier":"MIR:00000235","uris":["urn:miriam:mirbase.mature"]},"MI_R_BASE_SEQUENCE":{"commonName":"miRBase Sequence Database","homepage":"http://www.mirbase.org/","registryIdentifier":"MIR:00000078","uris":["urn:miriam:mirbase"]},"OMIM":{"commonName":"Online Mendelian Inheritance in Man","homepage":"http://omim.org/","registryIdentifier":"MIR:00000016","uris":["urn:miriam:omim"]},"PANTHER":{"commonName":"PANTHER Family","homepage":"http://www.pantherdb.org/","registryIdentifier":"MIR:00000060","uris":["urn:miriam:panther.family","urn:miriam:panther"]},"PDB":{"commonName":"Protein Data Bank","homepage":"http://www.pdbe.org/","registryIdentifier":"MIR:00000020","uris":["urn:miriam:pdb"]},"PFAM":{"commonName":"Protein Family Database","homepage":"http://pfam.xfam.org//","registryIdentifier":"MIR:00000028","uris":["urn:miriam:pfam"]},"PHARM":{"commonName":"PharmGKB Pathways","homepage":"http://www.pharmgkb.org/","registryIdentifier":"MIR:00000089","uris":["urn:miriam:pharmgkb.pathways"]},"PUBCHEM":{"commonName":"PubChem-compound","homepage":"http://pubchem.ncbi.nlm.nih.gov/","registryIdentifier":"MIR:00000034","uris":["urn:miriam:pubchem.compound"]},"PUBCHEM_SUBSTANCE":{"commonName":"PubChem-substance","homepage":"http://pubchem.ncbi.nlm.nih.gov/","registryIdentifier":"MIR:00000033","uris":["urn:miriam:pubchem.substance"]},"PUBMED":{"commonName":"PubMed","homepage":"http://www.ncbi.nlm.nih.gov/PubMed/","registryIdentifier":"MIR:00000015","uris":["urn:miriam:pubmed"]},"REACTOME":{"commonName":"Reactome","homepage":"http://www.reactome.org/","registryIdentifier":"MIR:00000018","uris":["urn:miriam:reactome"]},"REFSEQ":{"commonName":"RefSeq","homepage":"http://www.ncbi.nlm.nih.gov/projects/RefSeq/","registryIdentifier":"MIR:00000039","uris":["urn:miriam:refseq"]},"SGD":{"commonName":"Saccharomyces Genome Database","homepage":"http://www.yeastgenome.org/","registryIdentifier":"MIR:00000023","uris":["urn:miriam:sgd"]},"STITCH":{"commonName":"STITCH","homepage":"http://stitch.embl.de/","registryIdentifier":"MIR:00100343","uris":["urn:miriam:stitch"]},"STRING":{"commonName":"STRING","homepage":"http://string-db.org/","registryIdentifier":"MIR:00000265","uris":["urn:miriam:string"]},"TAIR_LOCUS":{"commonName":"TAIR Locus","homepage":"http://arabidopsis.org/index.jsp","registryIdentifier":"MIR:00000050","uris":["urn:miriam:tair.locus"]},"TAXONOMY":{"commonName":"Taxonomy","homepage":"http://www.ncbi.nlm.nih.gov/taxonomy/","registryIdentifier":"MIR:00000006","uris":["urn:miriam:taxonomy"]},"TOXICOGENOMIC_CHEMICAL":{"commonName":"Toxicogenomic Chemical","homepage":"http://ctdbase.org/","registryIdentifier":"MIR:00000098","uris":["urn:miriam:ctd.chemical"]},"UNIGENE":{"commonName":"UniGene","homepage":"http://www.ncbi.nlm.nih.gov/unigene","registryIdentifier":"MIR:00000346","uris":["urn:miriam:unigene"]},"UNIPROT":{"commonName":"Uniprot","homepage":"http://www.uniprot.org/","registryIdentifier":"MIR:00000005","uris":["urn:miriam:uniprot"]},"UNIPROT_ISOFORM":{"commonName":"UniProt Isoform","homepage":"http://www.uniprot.org/","registryIdentifier":"MIR:00000388","uris":["urn:miriam:uniprot.isoform"]},"UNKNOWN":{"commonName":"Unknown","homepage":null,"registryIdentifier":null,"uris":[]},"WIKIDATA":{"commonName":"Wikidata","homepage":"https://www.wikidata.org/","registryIdentifier":"MIR:00000549","uris":["urn:miriam:wikidata"]},"WIKIPATHWAYS":{"commonName":"WikiPathways","homepage":"http://www.wikipathways.org/","registryIdentifier":"MIR:00000076","uris":["urn:miriam:wikipathways"]},"WIKIPEDIA":{"commonName":"Wikipedia (English)","homepage":"http://en.wikipedia.org/wiki/Main_Page","registryIdentifier":"MIR:00000384","uris":["urn:miriam:wikipedia.en"]},"WORM_BASE":{"commonName":"WormBase","homepage":"http://wormbase.bio2rdf.org/fct","registryIdentifier":"MIR:00000027","uris":["urn:miriam:wormbase"]}},"modelFormats":[{"extension":"xml","handler":"lcsb.mapviewer.converter.model.celldesigner.CellDesignerXmlParser","name":"CellDesigner SBML"},{"extension":"sbgn","handler":"lcsb.mapviewer.converter.model.sbgnml.SbgnmlXmlConverter","name":"SBGN-ML"},{"extension":"xml","handler":"lcsb.mapviewer.converter.model.sbml.SbmlParser","name":"SBML"}],"modificationStateTypes":{"ACETYLATED":{"abbreviation":"Ac","commonName":"acetylated"},"DONT_CARE":{"abbreviation":"*","commonName":"don't care"},"EMPTY":{"abbreviation":"","commonName":"empty"},"GLYCOSYLATED":{"abbreviation":"G","commonName":"glycosylated"},"HYDROXYLATED":{"abbreviation":"OH","commonName":"hydroxylated"},"METHYLATED":{"abbreviation":"Me","commonName":"methylated"},"MYRISTOYLATED":{"abbreviation":"My","commonName":"myristoylated"},"PALMYTOYLATED":{"abbreviation":"Pa","commonName":"palmytoylated"},"PHOSPHORYLATED":{"abbreviation":"P","commonName":"phosphorylated"},"PRENYLATED":{"abbreviation":"Pr","commonName":"prenylated"},"PROTONATED":{"abbreviation":"H","commonName":"protonated"},"SULFATED":{"abbreviation":"S","commonName":"sulfated"},"UBIQUITINATED":{"abbreviation":"Ub","commonName":"ubiquitinated"},"UNKNOWN":{"abbreviation":"?","commonName":"unknown"}},"options":[{"idObject":9,"type":"EMAIL_ADDRESS","value":"gawron13@o2.pl","valueType":"EMAIL","commonName":"E-mail address"},{"idObject":10,"type":"EMAIL_LOGIN","value":"gawron13","valueType":"STRING","commonName":"E-mail server login"},{"idObject":11,"type":"EMAIL_PASSWORD","value":"k13liszk!","valueType":"PASSWORD","commonName":"E-mail server password"},{"idObject":13,"type":"EMAIL_IMAP_SERVER","value":"your.imap.domain.com","valueType":"STRING","commonName":"IMAP server"},{"idObject":12,"type":"EMAIL_SMTP_SERVER","value":"poczta.o2.pl","valueType":"STRING","commonName":"SMTP server"},{"idObject":14,"type":"EMAIL_SMTP_PORT","value":"25","valueType":"INTEGER","commonName":"SMTP port"},{"idObject":6,"type":"DEFAULT_MAP","value":"sample","valueType":"STRING","commonName":"Default Project Id"},{"idObject":4,"type":"LOGO_IMG","value":"udl.png","valueType":"URL","commonName":"Logo icon"},{"idObject":3,"type":"LOGO_LINK","value":"http://wwwen.uni.lu/","valueType":"URL","commonName":"Logo link (after click)"},{"idObject":7,"type":"SEARCH_DISTANCE","value":"10","valueType":"DOUBLE","commonName":"Max distance for clicking on element (px)"},{"idObject":1,"type":"REQUEST_ACCOUNT_EMAIL","value":"your.email@domain.com","valueType":"EMAIL","commonName":"Email used for requesting an account"},{"idObject":8,"type":"SEARCH_RESULT_NUMBER","value":"100","valueType":"INTEGER","commonName":"Max number of results in search box. "},{"idObject":2,"type":"GOOGLE_ANALYTICS_IDENTIFIER","value":"","valueType":"STRING","commonName":"Google Analytics tracking ID used for statistics"},{"idObject":5,"type":"LOGO_TEXT","value":"University of Luxembourg","valueType":"STRING","commonName":"Logo description"},{"idObject":56,"type":"X_FRAME_DOMAIN","value":"http://localhost:8080/","valueType":"URL","commonName":"Domain allowed to connect via x-frame technology"},{"idObject":131,"type":"BIG_FILE_STORAGE_DIR","value":"minerva-big/","valueType":"STRING","commonName":"Path to store big files"},{"idObject":138,"type":"LEGEND_FILE_1","value":"resources/images/legend_a.png","valueType":"URL","commonName":"Legend 1 image file"},{"idObject":139,"type":"LEGEND_FILE_2","value":"resources/images/legend_b.png","valueType":"URL","commonName":"Legend 2 image file"},{"idObject":140,"type":"LEGEND_FILE_3","value":"resources/images/legend_c.png","valueType":"URL","commonName":"Legend 3 image file"},{"idObject":141,"type":"LEGEND_FILE_4","value":"resources/images/legend_d.png","valueType":"URL","commonName":"Legend 4 image file"},{"idObject":142,"type":"USER_MANUAL_FILE","value":"resources/other/user_guide.pdf","valueType":"URL","commonName":"User manual file"},{"idObject":205,"type":"MIN_COLOR_VAL","value":"FF0000","valueType":"COLOR","commonName":"Overlay color for negative values"},{"idObject":206,"type":"MAX_COLOR_VAL","value":"fbff00","valueType":"COLOR","commonName":"Overlay color for postive values"},{"idObject":218,"type":"SIMPLE_COLOR_VAL","value":"00ff40","valueType":"COLOR","commonName":"Overlay color when no values are defined"},{"idObject":239,"type":"NEUTRAL_COLOR_VAL","value":"0400ff","valueType":"COLOR","commonName":"Overlay color for value=0"},{"idObject":252,"type":"OVERLAY_OPACITY","value":"0.8","valueType":"DOUBLE","commonName":"Opacity used when drwaing data overlays (value between 0.0-1.0)"},{"idObject":253,"type":"REQUEST_ACCOUNT_DEFAULT_CONTENT","value":"Dear Diseas map team,\n\nI would like to request for an account.\n\nKind regards","valueType":"TEXT","commonName":"Email content used for requesting an account"},{"idObject":266,"type":"DEFAULT_VIEW_PROJECT","value":"true","valueType":"BOOLEAN","commonName":"Default user privilege for: View project"},{"idObject":267,"type":"DEFAULT_EDIT_COMMENTS_PROJECT","value":"true","valueType":"BOOLEAN","commonName":"Default user privilege for: Manage comments"},{"idObject":268,"type":"DEFAULT_LAYOUT_MANAGEMENT","value":"false","valueType":"BOOLEAN","commonName":"Default user privilege for: Manage layouts"}],"overlayTypes":[{"name":"GENERIC"},{"name":"GENETIC_VARIANT"}],"plugins":[],"privilegeTypes":{"ADD_MAP":{"commonName":"Add project","objectType":null,"valueType":"boolean"},"CONFIGURATION_MANAGE":{"commonName":"Manage configuration","objectType":null,"valueType":"boolean"},"CUSTOM_LAYOUTS":{"commonName":"Custom layouts","objectType":null,"valueType":"int"},"EDIT_COMMENTS_PROJECT":{"commonName":"Manage comments","objectType":"Project","valueType":"boolean"},"LAYOUT_MANAGEMENT":{"commonName":"Manage layouts","objectType":"Project","valueType":"boolean"},"LAYOUT_VIEW":{"commonName":"View layout","objectType":"Layout","valueType":"boolean"},"MANAGE_GENOMES":{"commonName":"Manage genomes","objectType":null,"valueType":"boolean"},"PROJECT_MANAGEMENT":{"commonName":"Map management","objectType":null,"valueType":"boolean"},"USER_MANAGEMENT":{"commonName":"User management","objectType":null,"valueType":"boolean"},"VIEW_PROJECT":{"commonName":"View project","objectType":"Project","valueType":"boolean"}},"reactionTypes":[{"className":"lcsb.mapviewer.model.map.reaction.type.CatalysisReaction","name":"Catalysis","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.UnknownPositiveInfluenceReaction","name":"Unknown positive influence","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.Reaction","name":"Generic Reaction","parentClass":"lcsb.mapviewer.model.map.BioEntity"},{"className":"lcsb.mapviewer.model.map.reaction.type.KnownTransitionOmittedReaction","name":"Known transition omitted","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.ReducedModulationReaction","name":"Reduced modulation","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.TranslationReaction","name":"Translation","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.HeterodimerAssociationReaction","name":"Heterodimer association","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.TranscriptionReaction","name":"Transcription","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.UnknownReducedTriggerReaction","name":"Unknown reduced trigger","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.UnknownNegativeInfluenceReaction","name":"Unknown negative influence","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.TruncationReaction","name":"Truncation","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.TransportReaction","name":"Transport","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.UnknownCatalysisReaction","name":"Unknown catalysis","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.ReducedTriggerReaction","name":"Reduced trigger","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.StateTransitionReaction","name":"State transition","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.PhysicalStimulationReaction","name":"Physical stimulation","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.BooleanLogicGateReaction","name":"Boolean logic gate","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.DissociationReaction","name":"Dissociation","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.InhibitionReaction","name":"Inhibition","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.ReducedPhysicalStimulationReaction","name":"Reduced physical stimulation","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.NegativeInfluenceReaction","name":"Negative influence","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.UnknownInhibitionReaction","name":"Unknown inhibition","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.ModulationReaction","name":"Modulation","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.PositiveInfluenceReaction","name":"Positive influence","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.UnknownReducedPhysicalStimulationReaction","name":"Unknown reduced physical stimulation","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.UnknownReducedModulationReaction","name":"Unknown reduced modulation","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.UnknownTransitionReaction","name":"Unknown transition","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"className":"lcsb.mapviewer.model.map.reaction.type.TriggerReaction","name":"Trigger","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"}],"unitTypes":[{"id":"AMPERE","name":"ampere"},{"id":"BECQUEREL","name":"becquerel"},{"id":"CANDELA","name":"candela"},{"id":"COULUMB","name":"coulumb"},{"id":"DIMENSIONLESS","name":"dimensionless"},{"id":"FARAD","name":"farad"},{"id":"GRAM","name":"gram"},{"id":"GRAY","name":"gray"},{"id":"HENRY","name":"henry"},{"id":"HERTZ","name":"hertz"},{"id":"ITEM","name":"item"},{"id":"JOULE","name":"joule"},{"id":"KATAL","name":"katal"},{"id":"KELVIN","name":"kelvin"},{"id":"KILOGRAM","name":"kilogram"},{"id":"LITRE","name":"litre"},{"id":"LUMEN","name":"lumen"},{"id":"LUX","name":"lux"},{"id":"METRE","name":"metre"},{"id":"MOLE","name":"mole"},{"id":"NEWTON","name":"newton"},{"id":"OHM","name":"ohm"},{"id":"PASCAL","name":"pascal"},{"id":"RADIAN","name":"radian"},{"id":"SECOND","name":"second"},{"id":"SIEMENS","name":"siemens"},{"id":"SIEVERT","name":"sievert"},{"id":"STERADIAN","name":"steradian"},{"id":"TESLA","name":"tesla"},{"id":"VOLT","name":"volt"},{"id":"WATT","name":"watt"},{"id":"WEBER","name":"weber"}],"version":"12.0.0~alpha.1"}
\ No newline at end of file
diff --git a/frontend-js/testFiles/apiCalls/projects/drug_target_sample/drugs.search/query=NADH&token=MOCK_TOKEN_ID& b/frontend-js/testFiles/apiCalls/projects/drug_target_sample/drugs.search/query=NADH&token=MOCK_TOKEN_ID&
index 1a51980dcb4b0f20077b1723a8220f8e2bc65156..37f69dd3b838308e4d7f91f798349516d51e37ae 100644
--- a/frontend-js/testFiles/apiCalls/projects/drug_target_sample/drugs.search/query=NADH&token=MOCK_TOKEN_ID&
+++ b/frontend-js/testFiles/apiCalls/projects/drug_target_sample/drugs.search/query=NADH&token=MOCK_TOKEN_ID&
@@ -1 +1 @@
-[{"bloodBrainBarrier":"YES","brandNames":[],"description":"NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). It forms NADP with the addition of a phosphate group to the 2' position of the adenosyl nucleotide through an ester linkage. (Dorland, 27th ed) ","id":"NADH","name":"NADH","references":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.drugbank.ca/drugs/DB00157","resource":"DB00157","type":"DRUGBANK"}],"synonyms":[],"targets":[{"name":"D-beta-hydroxybutyrate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A chemiluminescence-flow injection analysis of serum 3-hydroxybutyrate using a bioreactor consisting of 3-hydroxybutyrate dehydrogenase and NADH oxidase.","authors":["Tabata M"," Totani M."],"journal":"Analytical biochemistry","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8533882","id":"8533882","citationCount":5,"stringAuthors":"Tabata M,  Totani M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8533882","resource":"8533882","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Coenzyme binding by 3-hydroxybutyrate dehydrogenase, a lipid-requiring enzyme: lecithin acts as an allosteric modulator to enhance the affinity for coenzyme.","authors":["Rudy B"," Dubois H"," Mink R"," Trommer WE"," McIntyre JO"," Fleischer S."],"journal":"Biochemistry","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2550053","id":"2550053","citationCount":8,"stringAuthors":"Rudy B,  Dubois H,  Mink R,  Trommer WE,  McIntyre JO,  Fleischer S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2550053","resource":"2550053","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Activities of NAD-specific and NADP-specific isocitrate dehydrogenases in rat-liver mitochondria. Studies with D-threo-alpha-methylisocitrate.","authors":["Smith CM"," Plaut GW."],"journal":"European journal of biochemistry","year":1979,"link":"http://www.ncbi.nlm.nih.gov/pubmed/38961","id":"38961","citationCount":11,"stringAuthors":"Smith CM,  Plaut GW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/38961","resource":"38961","type":"PUBMED"}],"targetElements":[{"id":436152,"modelId":20637,"type":"ALIAS"}],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=BDH1","resource":"BDH1","type":"HGNC_SYMBOL"}]},{"name":"11-cis retinol dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"Analysis of the NADH-dependent retinaldehyde reductase activity of amphioxus retinol dehydrogenase enzymes enhances our understanding of the evolution of the retinol dehydrogenase family.","authors":["Dalfó D"," Marqués N"," Albalat R."],"journal":"The FEBS journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17608724","id":"17608724","citationCount":10,"stringAuthors":"Dalfó D,  Marqués N,  Albalat R."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17608724","resource":"17608724","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=RDH5","resource":"RDH5","type":"HGNC_SYMBOL"}]},{"name":"15-hydroxyprostaglandin dehydrogenase [NAD(+)]","references":[{"annotatorClassName":"","article":{"title":"Corticotropin-releasing hormone receptor type 1 and type 2 mediate differential effects on 15-hydroxy prostaglandin dehydrogenase expression in cultured human chorion trophoblasts.","authors":["Gao L"," He P"," Sha J"," Liu C"," Dai L"," Hui N"," Ni X."],"journal":"Endocrinology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17463062","id":"17463062","citationCount":10,"stringAuthors":"Gao L,  He P,  Sha J,  Liu C,  Dai L,  Hui N,  Ni X."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17463062","resource":"17463062","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HPGD","resource":"HPGD","type":"HGNC_SYMBOL"}]},{"name":"2-oxoglutarate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"The tricarboxylic acid cycle, an ancient metabolic network with a novel twist.","authors":["Mailloux RJ"," Bériault R"," Lemire J"," Singh R"," Chénier DR"," Hamel RD"," Appanna VD."],"journal":"PloS one","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17668068","id":"17668068","citationCount":101,"stringAuthors":"Mailloux RJ,  Bériault R,  Lemire J,  Singh R,  Chénier DR,  Hamel RD,  Appanna VD."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17668068","resource":"17668068","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=OGDH","resource":"OGDH","type":"HGNC_SYMBOL"}]},{"name":"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of testosterone biosynthesis by ethanol: multiple sites and mechanisms in dispersed Leydig cells.","authors":["Widenius TV"," Orava MM"," Vihko RK"," Ylikahri RH"," Eriksson CJ."],"journal":"Journal of steroid biochemistry","year":1987,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3476810","id":"3476810","citationCount":14,"stringAuthors":"Widenius TV,  Orava MM,  Vihko RK,  Ylikahri RH,  Eriksson CJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3476810","resource":"3476810","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Affinity alkylation of human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase by 2 alpha-bromoacetoxyprogesterone: evidence for separate dehydrogenase and isomerase sites on one protein.","authors":["Thomas JL"," Myers RP"," Rosik LO"," Strickler RC."],"journal":"Journal of steroid biochemistry","year":1990,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2362440","id":"2362440","citationCount":4,"stringAuthors":"Thomas JL,  Myers RP,  Rosik LO,  Strickler RC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2362440","resource":"2362440","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Testicular and adrenal 3 beta-hydroxy-5-ene-steroid dehydrogenase and 5-ene-4-ene isomerase.","authors":["Ishii-Ohba H"," Inano H"," Tamaoki B."],"journal":"Journal of steroid biochemistry","year":1987,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2961942","id":"2961942","citationCount":10,"stringAuthors":"Ishii-Ohba H,  Inano H,  Tamaoki B."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2961942","resource":"2961942","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD3B1","resource":"HSD3B1","type":"HGNC_SYMBOL"}]},{"name":"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of testosterone biosynthesis by ethanol: multiple sites and mechanisms in dispersed Leydig cells.","authors":["Widenius TV"," Orava MM"," Vihko RK"," Ylikahri RH"," Eriksson CJ."],"journal":"Journal of steroid biochemistry","year":1987,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3476810","id":"3476810","citationCount":14,"stringAuthors":"Widenius TV,  Orava MM,  Vihko RK,  Ylikahri RH,  Eriksson CJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3476810","resource":"3476810","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Studies of the human testis. VII. Conversion of pregnenolone to progesterone.","authors":["Fan DF"," Troen P."],"journal":"The Journal of clinical endocrinology and metabolism","year":1975,"link":"http://www.ncbi.nlm.nih.gov/pubmed/239964","id":"239964","citationCount":8,"stringAuthors":"Fan DF,  Troen P."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/239964","resource":"239964","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Analysis of coenzyme binding by human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase using 5'-[p-(fluorosulfonyl)benzoyl]adenosine, an affinity labeling cofactor analog.","authors":["Thomas JL"," Myers RP"," Strickler RC."],"journal":"The Journal of steroid biochemistry and molecular biology","year":1991,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1911436","id":"1911436","citationCount":3,"stringAuthors":"Thomas JL,  Myers RP,  Strickler RC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1911436","resource":"1911436","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD3B2","resource":"HSD3B2","type":"HGNC_SYMBOL"}]},{"name":"3-hydroxy-3-methylglutaryl-coenzyme A reductase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Improved posthypoxic recovery in vitro on treatment with drugs used for secondary stroke prevention.","authors":["Huber R"," Riepe MW."],"journal":"Neuropharmacology","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15755483","id":"15755483","citationCount":1,"stringAuthors":"Huber R,  Riepe MW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15755483","resource":"15755483","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii.","authors":["Hedl M"," Rodwell VW."],"journal":"Protein science : a publication of the Protein Society","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15152097","id":"15152097","citationCount":10,"stringAuthors":"Hedl M,  Rodwell VW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15152097","resource":"15152097","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"3-hydroxy-3-methylglutaryl-coenzyme A reductase in the lobster mandibular organ: regulation by the eyestalk.","authors":["Li S"," Wagner CA"," Friesen JA"," Borst DW."],"journal":"General and comparative endocrinology","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14511985","id":"14511985","citationCount":13,"stringAuthors":"Li S,  Wagner CA,  Friesen JA,  Borst DW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14511985","resource":"14511985","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HMGCR","resource":"HMGCR","type":"HGNC_SYMBOL"}]},{"name":"3-hydroxyacyl-CoA dehydrogenase type-2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B10","resource":"HSD17B10","type":"HGNC_SYMBOL"}]},{"name":"3-hydroxyisobutyrate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HIBADH","resource":"HIBADH","type":"HGNC_SYMBOL"}]},{"name":"3-keto-steroid reductase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B7","resource":"HSD17B7","type":"HGNC_SYMBOL"}]},{"name":"4-trimethylaminobutyraldehyde dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Properties of gamma-aminobutyraldehyde dehydrogenase from Escherichia coli.","authors":["Prieto MI"," Martin J"," Balaña-Fouce R"," Garrido-Pertierra A."],"journal":"Biochimie","year":1987,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3129020","id":"3129020","citationCount":5,"stringAuthors":"Prieto MI,  Martin J,  Balaña-Fouce R,  Garrido-Pertierra A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3129020","resource":"3129020","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Purification and kinetic characterization of gamma-aminobutyraldehyde dehydrogenase from rat liver.","authors":["Testore G"," Colombatto S"," Silvagno F"," Bedino S."],"journal":"The international journal of biochemistry & cell biology","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7584606","id":"7584606","citationCount":4,"stringAuthors":"Testore G,  Colombatto S,  Silvagno F,  Bedino S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7584606","resource":"7584606","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH9A1","resource":"ALDH9A1","type":"HGNC_SYMBOL"}]},{"name":"7-dehydrocholesterol reductase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DHCR7","resource":"DHCR7","type":"HGNC_SYMBOL"}]},{"name":"Acyl carrier protein, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFAB1","resource":"NDUFAB1","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase 1A","references":[{"annotatorClassName":"","article":{"title":"Synthetic lethal and biochemical analyses of NAD and NADH kinases in Saccharomyces cerevisiae establish separation of cellular functions.","authors":["Bieganowski P"," Seidle HF"," Wojcik M"," Brenner C."],"journal":"The Journal of biological chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16760478","id":"16760478","citationCount":25,"stringAuthors":"Bieganowski P,  Seidle HF,  Wojcik M,  Brenner C."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16760478","resource":"16760478","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Two highly divergent alcohol dehydrogenases of melon exhibit fruit ripening-specific expression and distinct biochemical characteristics.","authors":["Manríquez D"," El-Sharkawy I"," Flores FB"," El-Yahyaoui F"," Regad F"," Bouzayen M"," Latché A"," Pech JC."],"journal":"Plant molecular biology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16897483","id":"16897483","citationCount":34,"stringAuthors":"Manríquez D,  El-Sharkawy I,  Flores FB,  El-Yahyaoui F,  Regad F,  Bouzayen M,  Latché A,  Pech JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16897483","resource":"16897483","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH1A","resource":"ADH1A","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase 1B","references":[{"annotatorClassName":"","article":{"title":"Two highly divergent alcohol dehydrogenases of melon exhibit fruit ripening-specific expression and distinct biochemical characteristics.","authors":["Manríquez D"," El-Sharkawy I"," Flores FB"," El-Yahyaoui F"," Regad F"," Bouzayen M"," Latché A"," Pech JC."],"journal":"Plant molecular biology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16897483","id":"16897483","citationCount":34,"stringAuthors":"Manríquez D,  El-Sharkawy I,  Flores FB,  El-Yahyaoui F,  Regad F,  Bouzayen M,  Latché A,  Pech JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16897483","resource":"16897483","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH1B","resource":"ADH1B","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase 1C","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Specificity of human alcohol dehydrogenase 1C*2 (gamma2gamma2) for steroids and simulation of the uncompetitive inhibition of ethanol metabolism.","authors":["Plapp BV"," Berst KB."],"journal":"Chemico-biological interactions","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12604203","id":"12604203","citationCount":3,"stringAuthors":"Plapp BV,  Berst KB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12604203","resource":"12604203","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH1C","resource":"ADH1C","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase 4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Biochemical basis of mitochondrial acetaldehyde dismutation in Saccharomyces cerevisiae.","authors":["Thielen J"," Ciriacy M."],"journal":"Journal of bacteriology","year":1991,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1938903","id":"1938903","citationCount":3,"stringAuthors":"Thielen J,  Ciriacy M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1938903","resource":"1938903","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Mouse alcohol dehydrogenase 4: kinetic mechanism, substrate specificity and simulation of effects of ethanol on retinoid metabolism.","authors":["Plapp BV"," Mitchell JL"," Berst KB."],"journal":"Chemico-biological interactions","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11306066","id":"11306066","citationCount":4,"stringAuthors":"Plapp BV,  Mitchell JL,  Berst KB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11306066","resource":"11306066","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Ethanol-induced inhibition of testosterone biosynthesis in vitro: lack of acetaldehyde effect.","authors":["Widenius TV."],"journal":"Alcohol and alcoholism (Oxford, Oxfordshire)","year":1987,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3593480","id":"3593480","citationCount":2,"stringAuthors":"Widenius TV."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3593480","resource":"3593480","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH4","resource":"ADH4","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase class 4 mu/sigma chain","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Analysis of the NADH-dependent retinaldehyde reductase activity of amphioxus retinol dehydrogenase enzymes enhances our understanding of the evolution of the retinol dehydrogenase family.","authors":["Dalfó D"," Marqués N"," Albalat R."],"journal":"The FEBS journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17608724","id":"17608724","citationCount":10,"stringAuthors":"Dalfó D,  Marqués N,  Albalat R."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17608724","resource":"17608724","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Identification and immunohistochemistry of retinol dehydrogenase from bovine retinal pigment epithelium.","authors":["Suzuki Y"," Ishiguro S"," Tamai M."],"journal":"Biochimica et biophysica acta","year":1993,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8490052","id":"8490052","citationCount":12,"stringAuthors":"Suzuki Y,  Ishiguro S,  Tamai M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8490052","resource":"8490052","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Effect of thyroid hormone on the alcohol dehydrogenase activities in rat tissues.","authors":["Kim DS"," Lee CB"," Park YS"," Ahn YH"," Kim TW"," Kee CS"," Kang JS"," Om AS."],"journal":"Journal of Korean medical science","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11410692","id":"11410692","citationCount":1,"stringAuthors":"Kim DS,  Lee CB,  Park YS,  Ahn YH,  Kim TW,  Kee CS,  Kang JS,  Om AS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11410692","resource":"11410692","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH7","resource":"ADH7","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase class-3","references":[{"annotatorClassName":"","article":{"title":"High-resolution structures of formate dehydrogenase from Candida boidinii.","authors":["Schirwitz K"," Schmidt A"," Lamzin VS."],"journal":"Protein science : a publication of the Protein Society","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17525463","id":"17525463","citationCount":24,"stringAuthors":"Schirwitz K,  Schmidt A,  Lamzin VS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17525463","resource":"17525463","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"D-mannitol production by resting state whole cell biotrans-formation of D-fructose by heterologous mannitol and formate dehydrogenase gene expression in Bacillus megaterium.","authors":["Bäumchen C"," Roth AH"," Biedendieck R"," Malten M"," Follmann M"," Sahm H"," Bringer-Meyer S"," Jahn D."],"journal":"Biotechnology journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17619232","id":"17619232","citationCount":11,"stringAuthors":"Bäumchen C,  Roth AH,  Biedendieck R,  Malten M,  Follmann M,  Sahm H,  Bringer-Meyer S,  Jahn D."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17619232","resource":"17619232","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Enhanced activity of 3alpha-hydroxysteroid dehydrogenase by addition of the co-solvent 1-butyl-3-methylimidazolium (L)-lactate in aqueous phase of biphasic systems for reductive production of steroids.","authors":["Okochi M"," Nakagawa I"," Kobayashi T"," Hayashi S"," Furusaki S"," Honda H."],"journal":"Journal of biotechnology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17092593","id":"17092593","citationCount":7,"stringAuthors":"Okochi M,  Nakagawa I,  Kobayashi T,  Hayashi S,  Furusaki S,  Honda H."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17092593","resource":"17092593","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Logic gates and elementary computing by enzymes.","authors":["Baron R"," Lioubashevski O"," Katz E"," Niazov T"," Willner I."],"journal":"The journal of physical chemistry. A","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16821840","id":"16821840","citationCount":36,"stringAuthors":"Baron R,  Lioubashevski O,  Katz E,  Niazov T,  Willner I."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16821840","resource":"16821840","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH5","resource":"ADH5","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase X, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH1B1","resource":"ALDH1B1","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase family 1 member A3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Characterization of retinaldehyde dehydrogenase 3.","authors":["Graham CE"," Brocklehurst K"," Pickersgill RW"," Warren MJ."],"journal":"The Biochemical journal","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16241904","id":"16241904","citationCount":17,"stringAuthors":"Graham CE,  Brocklehurst K,  Pickersgill RW,  Warren MJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16241904","resource":"16241904","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH1A3","resource":"ALDH1A3","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase family 3 member B1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH3B1","resource":"ALDH3B1","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase family 3 member B2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH3B2","resource":"ALDH3B2","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase, dimeric NADP-preferring","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Activities of cytosolic aldehyde dehydrogenase isozymes in colon cancer: determination using selective, fluorimetric assays.","authors":["WroczyÅ„ski P"," Nowak M"," Wierzchowski J"," Szubert A"," PolaÅ„ski J."],"journal":"Acta poloniae pharmaceutica","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16583981","id":"16583981","citationCount":3,"stringAuthors":"WroczyÅ„ski P,  Nowak M,  Wierzchowski J,  Szubert A,  PolaÅ„ski J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16583981","resource":"16583981","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH3A1","resource":"ALDH3A1","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective.","authors":["Quintanilla ME"," Tampier L"," Sapag A"," Gerdtzen Z"," Israel Y."],"journal":"American journal of physiology. Endocrinology and metabolism","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17488809","id":"17488809","citationCount":17,"stringAuthors":"Quintanilla ME,  Tampier L,  Sapag A,  Gerdtzen Z,  Israel Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17488809","resource":"17488809","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake.","authors":["Quintanilla ME"," Israel Y"," Sapag A"," Tampier L."],"journal":"Addiction biology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16961761","id":"16961761","citationCount":56,"stringAuthors":"Quintanilla ME,  Israel Y,  Sapag A,  Tampier L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16961761","resource":"16961761","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH2","resource":"ALDH2","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"Journal of steroid biochemistry","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","id":"2615366","citationCount":0,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","resource":"2615366","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Microsomal 20 alpha-hydroxysteroid dehydrogenase activity for progesterone in human placenta.","authors":["Fukuda T"," Hirato K"," Yanaihara T"," Nakayama T."],"journal":"Endocrinologia japonica","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","id":"3463506","citationCount":2,"stringAuthors":"Fukuda T,  Hirato K,  Yanaihara T,  Nakayama T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","resource":"3463506","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene.","authors":["Burczynski ME"," Sridhar GR"," Palackal NT"," Penning TM."],"journal":"The Journal of biological chemistry","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11060293","id":"11060293","citationCount":72,"stringAuthors":"Burczynski ME,  Sridhar GR,  Palackal NT,  Penning TM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11060293","resource":"11060293","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C1","resource":"AKR1C1","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells.","authors":["Rizner TL"," Lin HK"," Peehl DM"," Steckelbroeck S"," Bauman DR"," Penning TM."],"journal":"Endocrinology","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12810547","id":"12810547","citationCount":65,"stringAuthors":"Rizner TL,  Lin HK,  Peehl DM,  Steckelbroeck S,  Bauman DR,  Penning TM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12810547","resource":"12810547","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Kinetics of allopregnanolone formation catalyzed by human 3 alpha-hydroxysteroid dehydrogenase type III (AKR1C2).","authors":["Trauger JW"," Jiang A"," Stearns BA"," LoGrasso PV."],"journal":"Biochemistry","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12416991","id":"12416991","citationCount":40,"stringAuthors":"Trauger JW,  Jiang A,  Stearns BA,  LoGrasso PV."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12416991","resource":"12416991","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C2","resource":"AKR1C2","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"Journal of steroid biochemistry","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","id":"2615366","citationCount":0,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","resource":"2615366","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer between progesterone and cofactor by human placental estradiol-17 beta dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"The Journal of steroid biochemistry and molecular biology","year":1990,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2146972","id":"2146972","citationCount":0,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2146972","resource":"2146972","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Bioluminescent assay of femtomole levels of estrone and estradiol.","authors":["Nicolas JC"," Boussioux AM"," Boularan AM"," Descomps B"," Crastes de Paulet A."],"journal":"Analytical biochemistry","year":1983,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6584048","id":"6584048","citationCount":5,"stringAuthors":"Nicolas JC,  Boussioux AM,  Boularan AM,  Descomps B,  Crastes de Paulet A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6584048","resource":"6584048","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C3","resource":"AKR1C3","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Purification and characterization of oxidoreductases-catalyzing carbonyl reduction of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human liver cytosol.","authors":["Atalla A"," Breyer-Pfaff U"," Maser E."],"journal":"Xenobiotica; the fate of foreign compounds in biological systems","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11037109","id":"11037109","citationCount":29,"stringAuthors":"Atalla A,  Breyer-Pfaff U,  Maser E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11037109","resource":"11037109","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C4","resource":"AKR1C4","type":"HGNC_SYMBOL"}]},{"name":"Aldose reductase","references":[{"annotatorClassName":"","article":{"title":"Pyridine nucleotide redox abnormalities in diabetes.","authors":["Ido Y."],"journal":"Antioxidants & redox signaling","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","id":"17508915","citationCount":36,"stringAuthors":"Ido Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","resource":"17508915","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Vitamin C. Biosynthesis, recycling and degradation in mammals.","authors":["Linster CL"," Van Schaftingen E."],"journal":"The FEBS journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17222174","id":"17222174","citationCount":175,"stringAuthors":"Linster CL,  Van Schaftingen E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17222174","resource":"17222174","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1B1","resource":"AKR1B1","type":"HGNC_SYMBOL"}]},{"name":"Alpha-aminoadipic semialdehyde dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes.","authors":["de La Fuente JL"," Rumbero A"," Martín JF"," Liras P."],"journal":"The Biochemical journal","year":1997,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9355735","id":"9355735","citationCount":10,"stringAuthors":"de La Fuente JL,  Rumbero A,  Martín JF,  Liras P."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9355735","resource":"9355735","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH7A1","resource":"ALDH7A1","type":"HGNC_SYMBOL"}]},{"name":"Alpha-aminoadipic semialdehyde synthase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Determinants of substrate specificity for saccharopine dehydrogenase from Saccharomyces cerevisiae.","authors":["Xu H"," West AH"," Cook PF."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17542618","id":"17542618","citationCount":3,"stringAuthors":"Xu H,  West AH,  Cook PF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17542618","resource":"17542618","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Overall kinetic mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae.","authors":["Xu H"," West AH"," Cook PF."],"journal":"Biochemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17002315","id":"17002315","citationCount":12,"stringAuthors":"Xu H,  West AH,  Cook PF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17002315","resource":"17002315","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A proposed proton shuttle mechanism for saccharopine dehydrogenase from Saccharomyces cerevisiae.","authors":["Xu H"," Alguindigue SS"," West AH"," Cook PF."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17223709","id":"17223709","citationCount":9,"stringAuthors":"Xu H,  Alguindigue SS,  West AH,  Cook PF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17223709","resource":"17223709","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AASS","resource":"AASS","type":"HGNC_SYMBOL"}]},{"name":"Aminomethyltransferase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AMT","resource":"AMT","type":"HGNC_SYMBOL"}]},{"name":"Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MTHFD2","resource":"MTHFD2","type":"HGNC_SYMBOL"}]},{"name":"Biliverdin reductase A","references":[{"annotatorClassName":"","article":{"title":"Activation of biliverdin-IXalpha reductase by inorganic phosphate and related anions.","authors":["Franklin E"," Browne S"," Hayes J"," Boland C"," Dunne A"," Elliot G"," Mantle TJ."],"journal":"The Biochemical journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17402939","id":"17402939","citationCount":4,"stringAuthors":"Franklin E,  Browne S,  Hayes J,  Boland C,  Dunne A,  Elliot G,  Mantle TJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17402939","resource":"17402939","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=BLVRA","resource":"BLVRA","type":"HGNC_SYMBOL"}]},{"name":"C-1-tetrahydrofolate synthase, cytoplasmic","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MTHFD1","resource":"MTHFD1","type":"HGNC_SYMBOL"}]},{"name":"Corticosteroid 11-beta-dehydrogenase isozyme 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Metabolism of dexamethasone in the human kidney: nicotinamide adenine dinucleotide-dependent 11beta-reduction.","authors":["Diederich S"," Hanke B"," Oelkers W"," Bähr V."],"journal":"The Journal of Clinical Endocrinology and Metabolism","year":1997,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9141556","id":"9141556","citationCount":15,"stringAuthors":"Diederich S,  Hanke B,  Oelkers W,  Bähr V."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9141556","resource":"9141556","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Comparison of 11 beta-hydroxysteroid dehydrogenase in spontaneously hypertensive and Wistar-Kyoto rats.","authors":["Hermans JJ"," Steckel B"," Thijssen HH"," Janssen BJ"," Netter KJ"," Maser E."],"journal":"Steroids","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8585102","id":"8585102","citationCount":3,"stringAuthors":"Hermans JJ,  Steckel B,  Thijssen HH,  Janssen BJ,  Netter KJ,  Maser E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8585102","resource":"8585102","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD11B1","resource":"HSD11B1","type":"HGNC_SYMBOL"}]},{"name":"Corticosteroid 11-beta-dehydrogenase isozyme 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Localization of an 11 beta hydroxysteroid dehydrogenase activity to the distal nephron. Evidence for the existence of two species of dehydrogenase in the rat kidney.","authors":["Mercer WR"," Krozowski ZS."],"journal":"Endocrinology","year":1992,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1727721","id":"1727721","citationCount":62,"stringAuthors":"Mercer WR,  Krozowski ZS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1727721","resource":"1727721","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Comparison of 11 beta-hydroxysteroid dehydrogenase in spontaneously hypertensive and Wistar-Kyoto rats.","authors":["Hermans JJ"," Steckel B"," Thijssen HH"," Janssen BJ"," Netter KJ"," Maser E."],"journal":"Steroids","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8585102","id":"8585102","citationCount":3,"stringAuthors":"Hermans JJ,  Steckel B,  Thijssen HH,  Janssen BJ,  Netter KJ,  Maser E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8585102","resource":"8585102","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD11B2","resource":"HSD11B2","type":"HGNC_SYMBOL"}]},{"name":"Cysteine dioxygenase type 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=CDO1","resource":"CDO1","type":"HGNC_SYMBOL"}]},{"name":"Cytochrome P450 4A11","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cytochrome P450 4A, peroxisomal enzymes and nicotinamide cofactors in koala liver.","authors":["Ngo S"," Kong S"," Kirlich A"," McKinnon RA"," Stupans I."],"journal":"Comparative biochemistry and physiology. Toxicology & pharmacology : CBP","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11246504","id":"11246504","citationCount":6,"stringAuthors":"Ngo S,  Kong S,  Kirlich A,  McKinnon RA,  Stupans I."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11246504","resource":"11246504","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=CYP4A11","resource":"CYP4A11","type":"HGNC_SYMBOL"}]},{"name":"D-3-phosphoglycerate dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A new family of 2-hydroxyacid dehydrogenases.","authors":["Grant GA."],"journal":"Biochemical and biophysical research communications","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2692566","id":"2692566","citationCount":37,"stringAuthors":"Grant GA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2692566","resource":"2692566","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Serine biosynthesis in human hair follicles by the phosphorylated pathway: follicular 3-phosphoglycerate dehydrogenase.","authors":["Goldsmith LA"," O'Barr T."],"journal":"The Journal of investigative dermatology","year":1976,"link":"http://www.ncbi.nlm.nih.gov/pubmed/945314","id":"945314","citationCount":4,"stringAuthors":"Goldsmith LA,  O'Barr T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/945314","resource":"945314","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cofactor binding to Escherichia coli D-3-phosphoglycerate dehydrogenase induces multiple conformations which alter effector binding.","authors":["Grant GA"," Hu Z"," Xu XL."],"journal":"The Journal of biological chemistry","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12183470","id":"12183470","citationCount":9,"stringAuthors":"Grant GA,  Hu Z,  Xu XL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12183470","resource":"12183470","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PHGDH","resource":"PHGDH","type":"HGNC_SYMBOL"}]},{"name":"Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Crystal structure of Thermus thermophilus Delta1-pyrroline-5-carboxylate dehydrogenase.","authors":["Inagaki E"," Ohshima N"," Takahashi H"," Kuroishi C"," Yokoyama S"," Tahirov TH."],"journal":"Journal of molecular biology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16934832","id":"16934832","citationCount":35,"stringAuthors":"Inagaki E,  Ohshima N,  Takahashi H,  Kuroishi C,  Yokoyama S,  Tahirov TH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16934832","resource":"16934832","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH4A1","resource":"ALDH4A1","type":"HGNC_SYMBOL"}]},{"name":"Dihydrofolate reductase","references":[{"annotatorClassName":"","article":{"title":"Proteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis.","authors":["Argyrou A"," Jin L"," Siconilfi-Baez L"," Angeletti RH"," Blanchard JS."],"journal":"Biochemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17115689","id":"17115689","citationCount":38,"stringAuthors":"Argyrou A,  Jin L,  Siconilfi-Baez L,  Angeletti RH,  Blanchard JS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17115689","resource":"17115689","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence.","authors":["Vickers TJ"," Orsomando G"," de la Garza RD"," Scott DA"," Kang SO"," Hanson AD"," Beverley SM."],"journal":"The Journal of biological chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17032644","id":"17032644","citationCount":13,"stringAuthors":"Vickers TJ,  Orsomando G,  de la Garza RD,  Scott DA,  Kang SO,  Hanson AD,  Beverley SM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17032644","resource":"17032644","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DHFR","resource":"DHFR","type":"HGNC_SYMBOL"}]},{"name":"Dihydrolipoyl dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Histochemical staining and quantification of dihydrolipoamide dehydrogenase diaphorase activity using blue native PAGE.","authors":["Yan LJ"," Yang SH"," Shu H"," Prokai L"," Forster MJ."],"journal":"Electrophoresis","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17315258","id":"17315258","citationCount":25,"stringAuthors":"Yan LJ,  Yang SH,  Shu H,  Prokai L,  Forster MJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17315258","resource":"17315258","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Trypanosoma cruzi dihydrolipoamide dehydrogenase as target for phenothiazine cationic radicals. Effect of antioxidants.","authors":["Gutiérrez-Correa J."],"journal":"Current drug targets","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17017892","id":"17017892","citationCount":3,"stringAuthors":"Gutiérrez-Correa J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17017892","resource":"17017892","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A novel branched-chain amino acid metabolon. Protein-protein interactions in a supramolecular complex.","authors":["Islam MM"," Wallin R"," Wynn RM"," Conway M"," Fujii H"," Mobley JA"," Chuang DT"," Hutson SM."],"journal":"The Journal of biological chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17314104","id":"17314104","citationCount":32,"stringAuthors":"Islam MM,  Wallin R,  Wynn RM,  Conway M,  Fujii H,  Mobley JA,  Chuang DT,  Hutson SM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17314104","resource":"17314104","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DLD","resource":"DLD","type":"HGNC_SYMBOL"}]},{"name":"Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis.","authors":["Shi S"," Ehrt S."],"journal":"Infection and immunity","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16368957","id":"16368957","citationCount":40,"stringAuthors":"Shi S,  Ehrt S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16368957","resource":"16368957","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DLAT","resource":"DLAT","type":"HGNC_SYMBOL"}]},{"name":"Dihydropteridine reductase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Determination of NADPH-specific dihydropteridine reductase in extract from human, monkey, and bovine livers by single radial immunodiffusion: selective assay differentiating NADPH- and NADH-specific enzymes.","authors":["Nakanishi N"," Ozawa K"," Yamada S."],"journal":"Journal of biochemistry","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3086306","id":"3086306","citationCount":1,"stringAuthors":"Nakanishi N,  Ozawa K,  Yamada S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3086306","resource":"3086306","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Spectral studies of the interaction of the substrate 'quinonoid' 6-methyl dihydropterine and the coenzyme NADH used as marker in the dihydropteridine reductase assay.","authors":["van der Heiden C"," Brink W."],"journal":"Journal of inherited metabolic disease","year":1982,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6820434","id":"6820434","citationCount":0,"stringAuthors":"van der Heiden C,  Brink W."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6820434","resource":"6820434","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NADH-ferric reductase activity associated with dihydropteridine reductase.","authors":["Lee PL"," Halloran C"," Cross AR"," Beutler E."],"journal":"Biochemical and biophysical research communications","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10814540","id":"10814540","citationCount":3,"stringAuthors":"Lee PL,  Halloran C,  Cross AR,  Beutler E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10814540","resource":"10814540","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=QDPR","resource":"QDPR","type":"HGNC_SYMBOL"}]},{"name":"Estradiol 17-beta-dehydrogenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"Journal of steroid biochemistry","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","id":"2615366","citationCount":0,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","resource":"2615366","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Microsomal 20 alpha-hydroxysteroid dehydrogenase activity for progesterone in human placenta.","authors":["Fukuda T"," Hirato K"," Yanaihara T"," Nakayama T."],"journal":"Endocrinologia japonica","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","id":"3463506","citationCount":2,"stringAuthors":"Fukuda T,  Hirato K,  Yanaihara T,  Nakayama T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","resource":"3463506","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The 20 alpha-hydroxysteroid dehydrogenase of Streptomyces hydrogenans.","authors":["Rimsay RL"," Murphy GW"," Martin CJ"," Orr JC."],"journal":"European journal of biochemistry","year":1988,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3164265","id":"3164265","citationCount":1,"stringAuthors":"Rimsay RL,  Murphy GW,  Martin CJ,  Orr JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3164265","resource":"3164265","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B1","resource":"HSD17B1","type":"HGNC_SYMBOL"}]},{"name":"Estradiol 17-beta-dehydrogenase 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Microsomal 20 alpha-hydroxysteroid dehydrogenase activity for progesterone in human placenta.","authors":["Fukuda T"," Hirato K"," Yanaihara T"," Nakayama T."],"journal":"Endocrinologia japonica","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","id":"3463506","citationCount":2,"stringAuthors":"Fukuda T,  Hirato K,  Yanaihara T,  Nakayama T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","resource":"3463506","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"Journal of steroid biochemistry","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","id":"2615366","citationCount":0,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","resource":"2615366","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Prostaglandin-E2 9-reductase from corpus luteum of pseudopregnant rabbit is a member of the aldo-keto reductase superfamily featuring 20 alpha-hydroxysteroid dehydrogenase activity.","authors":["Wintergalen N"," Thole HH"," Galla HJ"," Schlegel W."],"journal":"European journal of biochemistry","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8529651","id":"8529651","citationCount":22,"stringAuthors":"Wintergalen N,  Thole HH,  Galla HJ,  Schlegel W."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8529651","resource":"8529651","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B2","resource":"HSD17B2","type":"HGNC_SYMBOL"}]},{"name":"Estradiol 17-beta-dehydrogenase 8","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B8","resource":"HSD17B8","type":"HGNC_SYMBOL"}]},{"name":"Fatty aldehyde dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Mechanism of a long-chain fatty aldehyde dehydrogenase induced during the development of bioluminescence in Beneckea harveyi.","authors":["Bognar A"," Meighen E."],"journal":"Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire","year":1983,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6603890","id":"6603890","citationCount":0,"stringAuthors":"Bognar A,  Meighen E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6603890","resource":"6603890","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH3A2","resource":"ALDH3A2","type":"HGNC_SYMBOL"}]},{"name":"Flavin reductase (NADPH)","references":[{"annotatorClassName":"","article":{"title":"Characterization of two components of the 2-naphthoate monooxygenase system from Burkholderia sp. strain JT1500.","authors":["Deng D"," Li X"," Fang X"," Sun G."],"journal":"FEMS microbiology letters","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17559398","id":"17559398","citationCount":1,"stringAuthors":"Deng D,  Li X,  Fang X,  Sun G."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17559398","resource":"17559398","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=BLVRB","resource":"BLVRB","type":"HGNC_SYMBOL"}]},{"name":"GDH/6PGL endoplasmic bifunctional protein","references":[{"annotatorClassName":"","article":{"title":"Electrochemical regeneration of NADH using conductive vanadia-silica xerogels.","authors":["Siu E"," Won K"," Park CB."],"journal":"Biotechnology progress","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17269701","id":"17269701","citationCount":10,"stringAuthors":"Siu E,  Won K,  Park CB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17269701","resource":"17269701","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Co-expression of P450 BM3 and glucose dehydrogenase by recombinant Escherichia coli and its application in an NADPH-dependent indigo production system.","authors":["Lu Y"," Mei L."],"journal":"Journal of industrial microbiology & biotechnology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17171348","id":"17171348","citationCount":10,"stringAuthors":"Lu Y,  Mei L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17171348","resource":"17171348","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"In vitro RNA editing in plant mitochondria does not require added energy.","authors":["Takenaka M"," Verbitskiy D"," van der Merwe JA"," Zehrmann A"," Plessmann U"," Urlaub H"," Brennicke A."],"journal":"FEBS letters","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17531229","id":"17531229","citationCount":3,"stringAuthors":"Takenaka M,  Verbitskiy D,  van der Merwe JA,  Zehrmann A,  Plessmann U,  Urlaub H,  Brennicke A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17531229","resource":"17531229","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"[Lymphocyte metabolism in patients with acute pancreatitis with different genotypes of GSTM1 and GSTT1 genes].","authors":["Markova EV"," Zotova NV"," Savchenko AA"," Titova NM"," Slepov EV"," Cherdantsev DV"," Konovalenko AN."],"journal":"Biomeditsinskaia khimiia","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","id":"16898590","citationCount":1,"stringAuthors":"Markova EV,  Zotova NV,  Savchenko AA,  Titova NM,  Slepov EV,  Cherdantsev DV,  Konovalenko AN."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","resource":"16898590","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Coimmobilization of dehydrogenases and their cofactors in electrochemical biosensors.","authors":["Zhang M"," Mullens C"," Gorski W."],"journal":"Analytical chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17298031","id":"17298031","citationCount":18,"stringAuthors":"Zhang M,  Mullens C,  Gorski W."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17298031","resource":"17298031","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=H6PD","resource":"H6PD","type":"HGNC_SYMBOL"}]},{"name":"GDP-L-fucose synthase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=TSTA3","resource":"TSTA3","type":"HGNC_SYMBOL"}]},{"name":"Glutamate dehydrogenase 1, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GLUD1","resource":"GLUD1","type":"HGNC_SYMBOL"}]},{"name":"Glutamate dehydrogenase 2, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GLUD2","resource":"GLUD2","type":"HGNC_SYMBOL"}]},{"name":"Glutathione reductase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Evidence for an additional disulfide reduction pathway in Escherichia coli.","authors":["Knapp KG"," Swartz JR."],"journal":"Journal of bioscience and bioengineering","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17502280","id":"17502280","citationCount":3,"stringAuthors":"Knapp KG,  Swartz JR."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17502280","resource":"17502280","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status.","authors":["Aon MA"," Cortassa S"," Maack C"," O'Rourke B."],"journal":"The Journal of biological chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17540766","id":"17540766","citationCount":92,"stringAuthors":"Aon MA,  Cortassa S,  Maack C,  O'Rourke B."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17540766","resource":"17540766","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Damage of oxidative stress on mitochondria during microspores development in Honglian CMS line of rice.","authors":["Wan C"," Li S"," Wen L"," Kong J"," Wang K"," Zhu Y."],"journal":"Plant cell reports","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17053903","id":"17053903","citationCount":22,"stringAuthors":"Wan C,  Li S,  Wen L,  Kong J,  Wang K,  Zhu Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17053903","resource":"17053903","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The relationship of the redox potentials of thioredoxin and thioredoxin reductase from Drosophila melanogaster to the enzymatic mechanism: reduced thioredoxin is the reductant of glutathione in Drosophila.","authors":["Cheng Z"," Arscott LD"," Ballou DP"," Williams CH."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17550271","id":"17550271","citationCount":27,"stringAuthors":"Cheng Z,  Arscott LD,  Ballou DP,  Williams CH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17550271","resource":"17550271","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Zinc irreversibly damages major enzymes of energy production and antioxidant defense prior to mitochondrial permeability transition.","authors":["Gazaryan IG"," Krasinskaya IP"," Kristal BS"," Brown AM."],"journal":"The Journal of biological chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17565998","id":"17565998","citationCount":59,"stringAuthors":"Gazaryan IG,  Krasinskaya IP,  Kristal BS,  Brown AM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17565998","resource":"17565998","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GSR","resource":"GSR","type":"HGNC_SYMBOL"}]},{"name":"Glyceraldehyde-3-phosphate dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"[Lymphocyte metabolism in patients with acute pancreatitis with different genotypes of GSTM1 and GSTT1 genes].","authors":["Markova EV"," Zotova NV"," Savchenko AA"," Titova NM"," Slepov EV"," Cherdantsev DV"," Konovalenko AN."],"journal":"Biomeditsinskaia khimiia","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","id":"16898590","citationCount":1,"stringAuthors":"Markova EV,  Zotova NV,  Savchenko AA,  Titova NM,  Slepov EV,  Cherdantsev DV,  Konovalenko AN."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","resource":"16898590","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Pyridine nucleotide redox abnormalities in diabetes.","authors":["Ido Y."],"journal":"Antioxidants & redox signaling","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","id":"17508915","citationCount":36,"stringAuthors":"Ido Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","resource":"17508915","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Thioredoxin-dependent regulation of photosynthetic glyceraldehyde-3-phosphate dehydrogenase: autonomous vs. CP12-dependent mechanisms.","authors":["Trost P"," Fermani S"," Marri L"," Zaffagnini M"," Falini G"," Scagliarini S"," Pupillo P"," Sparla F."],"journal":"Photosynthesis research","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17031544","id":"17031544","citationCount":28,"stringAuthors":"Trost P,  Fermani S,  Marri L,  Zaffagnini M,  Falini G,  Scagliarini S,  Pupillo P,  Sparla F."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17031544","resource":"17031544","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Sevoflurane modulates the activity of glyceraldehyde 3-phosphate dehydrogenase.","authors":["Swearengin TA"," Fibuch EE"," Seidler NW."],"journal":"Journal of enzyme inhibition and medicinal chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17194030","id":"17194030","citationCount":3,"stringAuthors":"Swearengin TA,  Fibuch EE,  Seidler NW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17194030","resource":"17194030","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GAPDH","resource":"GAPDH","type":"HGNC_SYMBOL"}]},{"name":"Glyceraldehyde-3-phosphate dehydrogenase, testis-specific","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Oral streptococcal glyceraldehyde-3-phosphate dehydrogenase mediates interaction with Porphyromonas gingivalis fimbriae.","authors":["Maeda K"," Nagata H"," Nonaka A"," Kataoka K"," Tanaka M"," Shizukuishi S."],"journal":"Microbes and infection","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15488735","id":"15488735","citationCount":20,"stringAuthors":"Maeda K,  Nagata H,  Nonaka A,  Kataoka K,  Tanaka M,  Shizukuishi S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15488735","resource":"15488735","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Characterization of native and recombinant A4 glyceraldehyde 3-phosphate dehydrogenase. Kinetic evidence for confromation changes upon association with the small protein CP12.","authors":["Graciet E"," Lebreton S"," Camadro JM"," Gontero B."],"journal":"European journal of biochemistry","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12492483","id":"12492483","citationCount":26,"stringAuthors":"Graciet E,  Lebreton S,  Camadro JM,  Gontero B."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12492483","resource":"12492483","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase.","authors":["Ismail SA"," Park HW."],"journal":"Acta crystallographica. Section D, Biological crystallography","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16239728","id":"16239728","citationCount":16,"stringAuthors":"Ismail SA,  Park HW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16239728","resource":"16239728","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GAPDHS","resource":"GAPDHS","type":"HGNC_SYMBOL"}]},{"name":"Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic","references":[{"annotatorClassName":"","article":{"title":"New competitive inhibitors of cytosolic (NADH-dependent) rabbit muscle glycerophosphate dehydrogenase.","authors":["Fonvielle M"," Therisod H"," Hemery M"," Therisod M."],"journal":"Bioorganic & medicinal chemistry letters","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17088060","id":"17088060","citationCount":0,"stringAuthors":"Fonvielle M,  Therisod H,  Hemery M,  Therisod M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17088060","resource":"17088060","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GPD1","resource":"GPD1","type":"HGNC_SYMBOL"}]},{"name":"Heme oxygenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Oxidative stress-related factors in Bartter's and Gitelman's syndromes: relevance for angiotensin II signalling.","authors":["Calò LA"," Pagnin E"," Davis PA"," Sartori M"," Semplicini A."],"journal":"Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12897089","id":"12897089","citationCount":26,"stringAuthors":"Calò LA,  Pagnin E,  Davis PA,  Sartori M,  Semplicini A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12897089","resource":"12897089","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae.","authors":["Auclair K"," Huang HW"," Moënne-Loccoz P"," Ortiz de Montellano PR."],"journal":"Protein expression and purification","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12699699","id":"12699699","citationCount":3,"stringAuthors":"Auclair K,  Huang HW,  Moënne-Loccoz P,  Ortiz de Montellano PR."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12699699","resource":"12699699","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HMOX1","resource":"HMOX1","type":"HGNC_SYMBOL"}]},{"name":"Heme oxygenase 2","references":[{"annotatorClassName":"","article":{"title":"DNA cleavage by UVA irradiation of NADH with dioxygen via radical chain processes.","authors":["Tanaka M"," Ohkubo K"," Fukuzumi S."],"journal":"The journal of physical chemistry. A","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16986858","id":"16986858","citationCount":20,"stringAuthors":"Tanaka M,  Ohkubo K,  Fukuzumi S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16986858","resource":"16986858","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inactivation of copper, zinc superoxide dismutase by H2O2 : mechanism of protection.","authors":["Goldstone AB"," Liochev SI"," Fridovich I."],"journal":"Free radical biology & medicine","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17157188","id":"17157188","citationCount":7,"stringAuthors":"Goldstone AB,  Liochev SI,  Fridovich I."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17157188","resource":"17157188","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HMOX2","resource":"HMOX2","type":"HGNC_SYMBOL"}]},{"name":"Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neurons.","authors":["Norman JP"," Perry SW"," Kasischke KA"," Volsky DJ"," Gelbard HA."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17202348","id":"17202348","citationCount":27,"stringAuthors":"Norman JP,  Perry SW,  Kasischke KA,  Volsky DJ,  Gelbard HA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17202348","resource":"17202348","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HADH","resource":"HADH","type":"HGNC_SYMBOL"}]},{"name":"Inosine-5'-monophosphate dehydrogenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Spectrum and frequency of mutations in IMPDH1 associated with autosomal dominant retinitis pigmentosa and leber congenital amaurosis.","authors":["Bowne SJ"," Sullivan LS"," Mortimer SE"," Hedstrom L"," Zhu J"," Spellicy CJ"," Gire AI"," Hughbanks-Wheaton D"," Birch DG"," Lewis RA"," Heckenlively JR"," Daiger SP."],"journal":"Investigative ophthalmology & visual science","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16384941","id":"16384941","citationCount":69,"stringAuthors":"Bowne SJ,  Sullivan LS,  Mortimer SE,  Hedstrom L,  Zhu J,  Spellicy CJ,  Gire AI,  Hughbanks-Wheaton D,  Birch DG,  Lewis RA,  Heckenlively JR,  Daiger SP."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16384941","resource":"16384941","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IMPDH1","resource":"IMPDH1","type":"HGNC_SYMBOL"}]},{"name":"Inosine-5'-monophosphate dehydrogenase 2","references":[{"annotatorClassName":"","article":{"title":"A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity.","authors":["Wang J"," Zeevi A"," Webber S"," Girnita DM"," Addonizio L"," Selby R"," Hutchinson IV"," Burckart GJ."],"journal":"Pharmacogenetics and genomics","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17496727","id":"17496727","citationCount":31,"stringAuthors":"Wang J,  Zeevi A,  Webber S,  Girnita DM,  Addonizio L,  Selby R,  Hutchinson IV,  Burckart GJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17496727","resource":"17496727","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IMPDH2","resource":"IMPDH2","type":"HGNC_SYMBOL"}]},{"name":"Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diphosphopyridine nucleotide isocitric dehydrogenase from animal tissues.","authors":["PLAUT GW"," SUNG SC."],"journal":"The Journal of biological chemistry","year":1954,"link":"http://www.ncbi.nlm.nih.gov/pubmed/13152105","id":"13152105","citationCount":36,"stringAuthors":"PLAUT GW,  SUNG SC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/13152105","resource":"13152105","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diphosphopyridine nucleotide specific isocitric dehydrogenase of mammalian mitochondria. I. On the roles of pyridine nucleotide transhydrogenase and the isocitric dehydrogenases in the respiration of mitochondria of normal and neoplastic tissues.","authors":["Stein AM"," Stein JH"," Kirkman SK."],"journal":"Biochemistry","year":1967,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","id":"4292141","citationCount":17,"stringAuthors":"Stein AM,  Stein JH,  Kirkman SK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","resource":"4292141","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The stereochemistry of the nicotinamide adenine dinucleotide-specific isocitric dehydrogenase reaction.","authors":["Rose ZB."],"journal":"The Journal of biological chemistry","year":1966,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","id":"4380379","citationCount":1,"stringAuthors":"Rose ZB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","resource":"4380379","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IDH3A","resource":"IDH3A","type":"HGNC_SYMBOL"}]},{"name":"Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diphosphopyridine nucleotide specific isocitric dehydrogenase of mammalian mitochondria. I. On the roles of pyridine nucleotide transhydrogenase and the isocitric dehydrogenases in the respiration of mitochondria of normal and neoplastic tissues.","authors":["Stein AM"," Stein JH"," Kirkman SK."],"journal":"Biochemistry","year":1967,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","id":"4292141","citationCount":17,"stringAuthors":"Stein AM,  Stein JH,  Kirkman SK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","resource":"4292141","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NICOTINAMIDE ADENINE DINUCLEOTIDE-SPECIFIC ISOCITRIC DEHYDROGENASE. A POSSIBLE REGULATORY PROTEIN.","authors":["SANWAL BD"," ZINK MW"," STACHOW CS."],"journal":"The Journal of biological chemistry","year":1964,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14189899","id":"14189899","citationCount":25,"stringAuthors":"SANWAL BD,  ZINK MW,  STACHOW CS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14189899","resource":"14189899","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The stereochemistry of the nicotinamide adenine dinucleotide-specific isocitric dehydrogenase reaction.","authors":["Rose ZB."],"journal":"The Journal of biological chemistry","year":1966,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","id":"4380379","citationCount":1,"stringAuthors":"Rose ZB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","resource":"4380379","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IDH3B","resource":"IDH3B","type":"HGNC_SYMBOL"}]},{"name":"Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diphosphopyridine nucleotide specific isocitric dehydrogenase of mammalian mitochondria. I. On the roles of pyridine nucleotide transhydrogenase and the isocitric dehydrogenases in the respiration of mitochondria of normal and neoplastic tissues.","authors":["Stein AM"," Stein JH"," Kirkman SK."],"journal":"Biochemistry","year":1967,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","id":"4292141","citationCount":17,"stringAuthors":"Stein AM,  Stein JH,  Kirkman SK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","resource":"4292141","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NICOTINAMIDE ADENINE DINUCLEOTIDE-SPECIFIC ISOCITRIC DEHYDROGENASE. A POSSIBLE REGULATORY PROTEIN.","authors":["SANWAL BD"," ZINK MW"," STACHOW CS."],"journal":"The Journal of biological chemistry","year":1964,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14189899","id":"14189899","citationCount":25,"stringAuthors":"SANWAL BD,  ZINK MW,  STACHOW CS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14189899","resource":"14189899","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The stereochemistry of the nicotinamide adenine dinucleotide-specific isocitric dehydrogenase reaction.","authors":["Rose ZB."],"journal":"The Journal of biological chemistry","year":1966,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","id":"4380379","citationCount":1,"stringAuthors":"Rose ZB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","resource":"4380379","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IDH3G","resource":"IDH3G","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase A chain","references":[{"annotatorClassName":"","article":{"title":"Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1.","authors":["Semenza GL."],"journal":"The Biochemical journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17555402","id":"17555402","citationCount":217,"stringAuthors":"Semenza GL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17555402","resource":"17555402","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Histochemical and histopathological study of the gastric mucosa in the portal hypertensive gastropathy.","authors":["Drăghia AC."],"journal":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17308685","id":"17308685","citationCount":3,"stringAuthors":"Drăghia AC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17308685","resource":"17308685","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Kinetic parameters and lactate dehydrogenase isozyme activities support possible lactate utilization by neurons.","authors":["O'Brien J"," Kla KM"," Hopkins IB"," Malecki EA"," McKenna MC."],"journal":"Neurochemical research","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17006762","id":"17006762","citationCount":30,"stringAuthors":"O'Brien J,  Kla KM,  Hopkins IB,  Malecki EA,  McKenna MC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17006762","resource":"17006762","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHA","resource":"LDHA","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase A-like 6A","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHAL6A","resource":"LDHAL6A","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase A-like 6B","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHAL6B","resource":"LDHAL6B","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase B chain","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Domain closure, substrate specificity and catalysis of D-lactate dehydrogenase from Lactobacillus bulgaricus.","authors":["Razeto A"," Kochhar S"," Hottinger H"," Dauter M"," Wilson KS"," Lamzin VS."],"journal":"Journal of molecular biology","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12054772","id":"12054772","citationCount":33,"stringAuthors":"Razeto A,  Kochhar S,  Hottinger H,  Dauter M,  Wilson KS,  Lamzin VS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12054772","resource":"12054772","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A preliminary account of the properties of recombinant human Glyoxylate reductase (GRHPR), LDHA and LDHB with glyoxylate, and their potential roles in its metabolism.","authors":["Mdluli K"," Booth MP"," Brady RL"," Rumsby G."],"journal":"Biochimica et biophysica acta","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16198644","id":"16198644","citationCount":16,"stringAuthors":"Mdluli K,  Booth MP,  Brady RL,  Rumsby G."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16198644","resource":"16198644","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Lactate dehydrogenase isoenzymes of sperm cells and tests.","authors":["Clausen J."],"journal":"The Biochemical journal","year":1969,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4303363","id":"4303363","citationCount":11,"stringAuthors":"Clausen J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4303363","resource":"4303363","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHB","resource":"LDHB","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase C chain","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Rapid purification of lactate dehydrogenase X from mouse testes by two steps of affinity chromatography on oxamate-sepharose.","authors":["Spielmann H"," Eibs HG"," Mentzel C."],"journal":"Experientia","year":1976,"link":"http://www.ncbi.nlm.nih.gov/pubmed/182529","id":"182529","citationCount":1,"stringAuthors":"Spielmann H,  Eibs HG,  Mentzel C."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/182529","resource":"182529","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of testicular LDH-X from laboratory animals and man by gossypol and its isomers.","authors":["Morris ID"," Higgins C"," Matlin SA."],"journal":"Journal of reproduction and fertility","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3735252","id":"3735252","citationCount":3,"stringAuthors":"Morris ID,  Higgins C,  Matlin SA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3735252","resource":"3735252","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Developmental changes in lactate dehydrogenase-X activity in young jaundiced male rats.","authors":["Gu Y"," Davis DR"," Lin YC."],"journal":"Archives of andrology","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2751392","id":"2751392","citationCount":10,"stringAuthors":"Gu Y,  Davis DR,  Lin YC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2751392","resource":"2751392","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHC","resource":"LDHC","type":"HGNC_SYMBOL"}]},{"name":"Malate dehydrogenase, cytoplasmic","references":[{"annotatorClassName":"","article":{"title":"Heterologous expression of cDNAs encoding monodehydroascorbate reductases from the moss, Physcomitrella patens and characterization of the expressed enzymes.","authors":["Drew DP"," Lunde C"," Lahnstein J"," Fincher GB."],"journal":"Planta","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16983536","id":"16983536","citationCount":7,"stringAuthors":"Drew DP,  Lunde C,  Lahnstein J,  Fincher GB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16983536","resource":"16983536","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MDH1","resource":"MDH1","type":"HGNC_SYMBOL"}]},{"name":"Malate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"D-mannitol production by resting state whole cell biotrans-formation of D-fructose by heterologous mannitol and formate dehydrogenase gene expression in Bacillus megaterium.","authors":["Bäumchen C"," Roth AH"," Biedendieck R"," Malten M"," Follmann M"," Sahm H"," Bringer-Meyer S"," Jahn D."],"journal":"Biotechnology journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17619232","id":"17619232","citationCount":11,"stringAuthors":"Bäumchen C,  Roth AH,  Biedendieck R,  Malten M,  Follmann M,  Sahm H,  Bringer-Meyer S,  Jahn D."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17619232","resource":"17619232","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Fluorescent sensing layer for the determination of L-malic acid in wine.","authors":["Gallarta F"," Sáinz FJ"," Sáenz C."],"journal":"Analytical and bioanalytical chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17203264","id":"17203264","citationCount":2,"stringAuthors":"Gallarta F,  Sáinz FJ,  Sáenz C."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17203264","resource":"17203264","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"[Lymphocyte metabolism in patients with acute pancreatitis with different genotypes of GSTM1 and GSTT1 genes].","authors":["Markova EV"," Zotova NV"," Savchenko AA"," Titova NM"," Slepov EV"," Cherdantsev DV"," Konovalenko AN."],"journal":"Biomeditsinskaia khimiia","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","id":"16898590","citationCount":1,"stringAuthors":"Markova EV,  Zotova NV,  Savchenko AA,  Titova NM,  Slepov EV,  Cherdantsev DV,  Konovalenko AN."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","resource":"16898590","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Characterization of malate dehydrogenase from the hyperthermophilic archaeon Pyrobaculum islandicum.","authors":["Yennaco LJ"," Hu Y"," Holden JF."],"journal":"Extremophiles : life under extreme conditions","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17487443","id":"17487443","citationCount":5,"stringAuthors":"Yennaco LJ,  Hu Y,  Holden JF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17487443","resource":"17487443","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"L-2-hydroxyglutaric aciduria, a defect of metabolite repair.","authors":["Rzem R"," Vincent MF"," Van Schaftingen E"," Veiga-da-Cunha M."],"journal":"Journal of inherited metabolic disease","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17603759","id":"17603759","citationCount":52,"stringAuthors":"Rzem R,  Vincent MF,  Van Schaftingen E,  Veiga-da-Cunha M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17603759","resource":"17603759","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MDH2","resource":"MDH2","type":"HGNC_SYMBOL"}]},{"name":"Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The effect of ligand binding on the proteolytic pattern of methylmalonate semialdehyde dehydrogenase.","authors":["Kedishvili NY"," Popov KM"," Harris RA."],"journal":"Archives of biochemistry and biophysics","year":1991,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1898092","id":"1898092","citationCount":1,"stringAuthors":"Kedishvili NY,  Popov KM,  Harris RA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1898092","resource":"1898092","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH6A1","resource":"ALDH6A1","type":"HGNC_SYMBOL"}]},{"name":"Methylsterol monooxygenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MSMO1","resource":"MSMO1","type":"HGNC_SYMBOL"}]},{"name":"NAD(P) transhydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Expression of the Escherichia coli pntAB genes encoding a membrane-bound transhydrogenase in Corynebacterium glutamicum improves L-lysine formation.","authors":["Kabus A"," Georgi T"," Wendisch VF"," Bott M."],"journal":"Applied microbiology and biotechnology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17216441","id":"17216441","citationCount":49,"stringAuthors":"Kabus A,  Georgi T,  Wendisch VF,  Bott M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17216441","resource":"17216441","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NNT","resource":"NNT","type":"HGNC_SYMBOL"}]},{"name":"NAD-dependent malic enzyme, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ME2","resource":"ME2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The NDUFA1 gene product (MWFE protein) is essential for activity of complex I in mammalian mitochondria.","authors":["Au HC"," Seo BB"," Matsuno-Yagi A"," Yagi T"," Scheffler IE."],"journal":"Proceedings of the National Academy of Sciences of the United States of America","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10200266","id":"10200266","citationCount":28,"stringAuthors":"Au HC,  Seo BB,  Matsuno-Yagi A,  Yagi T,  Scheffler IE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10200266","resource":"10200266","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase.","authors":["Raha S"," Myint AT"," Johnstone L"," Robinson BH."],"journal":"Free radical biology & medicine","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","id":"11864782","citationCount":45,"stringAuthors":"Raha S,  Myint AT,  Johnstone L,  Robinson BH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","resource":"11864782","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA1","resource":"NDUFA1","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA10","resource":"NDUFA10","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA11","resource":"NDUFA11","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA12","resource":"NDUFA12","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA13","resource":"NDUFA13","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA2","resource":"NDUFA2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA3","resource":"NDUFA3","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA4","resource":"NDUFA4","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA4L2","resource":"NDUFA4L2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5","references":[{"annotatorClassName":"","article":{"title":"Site-specific S-glutathiolation of mitochondrial NADH ubiquinone reductase.","authors":["Chen CL"," Zhang L"," Yeh A"," Chen CA"," Green-Church KB"," Zweier JL"," Chen YR."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17444656","id":"17444656","citationCount":42,"stringAuthors":"Chen CL,  Zhang L,  Yeh A,  Chen CA,  Green-Church KB,  Zweier JL,  Chen YR."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17444656","resource":"17444656","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Role of the conserved arginine 274 and histidine 224 and 228 residues in the NuoCD subunit of complex I from Escherichia coli.","authors":["Belevich G"," Euro L"," Wikström M"," Verkhovskaya M."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17209562","id":"17209562","citationCount":15,"stringAuthors":"Belevich G,  Euro L,  Wikström M,  Verkhovskaya M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17209562","resource":"17209562","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA5","resource":"NDUFA5","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA6","resource":"NDUFA6","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA7","resource":"NDUFA7","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The nuclear-encoded human NADH:ubiquinone oxidoreductase NDUFA8 subunit: cDNA cloning, chromosomal localization, tissue distribution, and mutation detection in complex-I-deficient patients.","authors":["Triepels R"," van den Heuvel L"," Loeffen J"," Smeets R"," Trijbels F"," Smeitink J."],"journal":"Human genetics","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9860297","id":"9860297","citationCount":5,"stringAuthors":"Triepels R,  van den Heuvel L,  Loeffen J,  Smeets R,  Trijbels F,  Smeitink J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9860297","resource":"9860297","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA8","resource":"NDUFA8","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"The flavoprotein subcomplex of complex I (NADH:ubiquinone oxidoreductase) from bovine heart mitochondria: insights into the mechanisms of NADH oxidation and NAD+ reduction from protein film voltammetry.","authors":["Barker CD"," Reda T"," Hirst J."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17323923","id":"17323923","citationCount":14,"stringAuthors":"Barker CD,  Reda T,  Hirst J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17323923","resource":"17323923","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Maintenance of the metabolic homeostasis of the heart: developing a systems analysis approach.","authors":["Balaban RS."],"journal":"Annals of the New York Academy of Sciences","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17132781","id":"17132781","citationCount":15,"stringAuthors":"Balaban RS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17132781","resource":"17132781","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of complex I by Ca2+ reduces electron transport activity and the rate of superoxide anion production in cardiac submitochondrial particles.","authors":["Matsuzaki S"," Szweda LI."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17260964","id":"17260964","citationCount":11,"stringAuthors":"Matsuzaki S,  Szweda LI."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17260964","resource":"17260964","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle.","authors":["Fisher N"," Bray PG"," Ward SA"," Biagini GA."],"journal":"Trends in parasitology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17499024","id":"17499024","citationCount":32,"stringAuthors":"Fisher N,  Bray PG,  Ward SA,  Biagini GA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17499024","resource":"17499024","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cloning and sequence analysis of the gene encoding 19-kD subunit of Complex I from Dunaliella salina.","authors":["Liu Y"," Qiao DR"," Zheng HB"," Dai XL"," Bai LH"," Zeng J"," Cao Y."],"journal":"Molecular biology reports","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17530440","id":"17530440","citationCount":3,"stringAuthors":"Liu Y,  Qiao DR,  Zheng HB,  Dai XL,  Bai LH,  Zeng J,  Cao Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17530440","resource":"17530440","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA9","resource":"NDUFA9","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB1","resource":"NDUFB1","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB10","resource":"NDUFB10","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB2","resource":"NDUFB2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB3","resource":"NDUFB3","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB4","resource":"NDUFB4","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB5","resource":"NDUFB5","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB6","resource":"NDUFB6","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase.","authors":["Raha S"," Myint AT"," Johnstone L"," Robinson BH."],"journal":"Free radical biology & medicine","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","id":"11864782","citationCount":45,"stringAuthors":"Raha S,  Myint AT,  Johnstone L,  Robinson BH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","resource":"11864782","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB7","resource":"NDUFB7","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB8","resource":"NDUFB8","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB9","resource":"NDUFB9","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFC1","resource":"NDUFC1","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 subunit C2","references":[{"annotatorClassName":"","article":{"title":"Regulatory loop between redox sensing of the NADH/NAD(+) ratio by Rex (YdiH) and oxidation of NADH by NADH dehydrogenase Ndh in Bacillus subtilis.","authors":["Gyan S"," Shiohira Y"," Sato I"," Takeuchi M"," Sato T."],"journal":"Journal of bacteriology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17015645","id":"17015645","citationCount":59,"stringAuthors":"Gyan S,  Shiohira Y,  Sato I,  Takeuchi M,  Sato T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17015645","resource":"17015645","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stimulation of chlororespiration by heat and high light intensity in oat plants.","authors":["Quiles MJ."],"journal":"Plant, cell & environment","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898010","id":"16898010","citationCount":36,"stringAuthors":"Quiles MJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898010","resource":"16898010","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Generation of a membrane potential by Lactococcus lactis through aerobic electron transport.","authors":["Brooijmans RJ"," Poolman B"," Schuurman-Wolters GK"," de Vos WM"," Hugenholtz J."],"journal":"Journal of bacteriology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17496098","id":"17496098","citationCount":31,"stringAuthors":"Brooijmans RJ,  Poolman B,  Schuurman-Wolters GK,  de Vos WM,  Hugenholtz J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17496098","resource":"17496098","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Association of MT-ND5 gene variation with mitochondrial respiratory control ratio and NADH dehydrogenase activity in Tibet chicken embryos.","authors":["Bao HG"," Zhao CJ"," Li JY"," Wu Ch."],"journal":"Animal genetics","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17614984","id":"17614984","citationCount":3,"stringAuthors":"Bao HG,  Zhao CJ,  Li JY,  Wu Ch."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17614984","resource":"17614984","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Ischemic preconditioning prevents in vivo hyperoxygenation in postischemic myocardium with preservation of mitochondrial oxygen consumption.","authors":["Zhu X"," Liu B"," Zhou S"," Chen YR"," Deng Y"," Zweier JL"," He G."],"journal":"American journal of physiology. Heart and circulatory physiology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17513495","id":"17513495","citationCount":19,"stringAuthors":"Zhu X,  Liu B,  Zhou S,  Chen YR,  Deng Y,  Zweier JL,  He G."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17513495","resource":"17513495","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFC2","resource":"NDUFC2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cloning of the human mitochondrial 51 kDa subunit (NDUFV1) reveals a 100% antisense homology of its 3'UTR with the 5'UTR of the gamma-interferon inducible protein (IP-30) precursor: is this a link between mitochondrial myopathy and inflammation?","authors":["Schuelke M"," Loeffen J"," Mariman E"," Smeitink J"," van den Heuvel L."],"journal":"Biochemical and biophysical research communications","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9571201","id":"9571201","citationCount":8,"stringAuthors":"Schuelke M,  Loeffen J,  Mariman E,  Smeitink J,  van den Heuvel L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9571201","resource":"9571201","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Chromosomal localization of the human gene encoding the 51-kDa subunit of mitochondrial complex I (NDUFV1) to 11q13.","authors":["Ali ST"," Duncan AM"," Schappert K"," Heng HH"," Tsui LC"," Chow W"," Robinson BH."],"journal":"Genomics","year":1993,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8288251","id":"8288251","citationCount":13,"stringAuthors":"Ali ST,  Duncan AM,  Schappert K,  Heng HH,  Tsui LC,  Chow W,  Robinson BH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8288251","resource":"8288251","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis.","authors":["Grad LI"," Lemire BD."],"journal":"Human molecular genetics","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14662656","id":"14662656","citationCount":52,"stringAuthors":"Grad LI,  Lemire BD."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14662656","resource":"14662656","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFV1","resource":"NDUFV1","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Identification of genes regulated by UV/salicylic acid.","authors":["Paunesku T"," Chang-Liu CM"," Shearin-Jones P"," Watson C"," Milton J"," Oryhon J"," Salbego D"," Milosavljevic A"," Woloschak GE."],"journal":"International journal of radiation biology","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10716640","id":"10716640","citationCount":2,"stringAuthors":"Paunesku T,  Chang-Liu CM,  Shearin-Jones P,  Watson C,  Milton J,  Oryhon J,  Salbego D,  Milosavljevic A,  Woloschak GE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10716640","resource":"10716640","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFV2","resource":"NDUFV2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFV3","resource":"NDUFV3","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS2","resource":"NDUFS2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS3","resource":"NDUFS3","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The NADH: ubiquinone oxidoreductase (complex I) of the mammalian respiratory chain and the cAMP cascade.","authors":["Papa S"," Sardanelli AM"," Scacco S"," Petruzzella V"," Technikova-Dobrova Z"," Vergari R"," Signorile A."],"journal":"Journal of bioenergetics and biomembranes","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11860175","id":"11860175","citationCount":23,"stringAuthors":"Papa S,  Sardanelli AM,  Scacco S,  Petruzzella V,  Technikova-Dobrova Z,  Vergari R,  Signorile A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11860175","resource":"11860175","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A nonsense mutation in the NDUFS4 gene encoding the 18 kDa (AQDQ) subunit of complex I abolishes assembly and activity of the complex in a patient with Leigh-like syndrome.","authors":["Petruzzella V"," Vergari R"," Puzziferri I"," Boffoli D"," Lamantea E"," Zeviani M"," Papa S."],"journal":"Human molecular genetics","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11181577","id":"11181577","citationCount":54,"stringAuthors":"Petruzzella V,  Vergari R,  Puzziferri I,  Boffoli D,  Lamantea E,  Zeviani M,  Papa S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11181577","resource":"11181577","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase.","authors":["Raha S"," Myint AT"," Johnstone L"," Robinson BH."],"journal":"Free radical biology & medicine","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","id":"11864782","citationCount":45,"stringAuthors":"Raha S,  Myint AT,  Johnstone L,  Robinson BH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","resource":"11864782","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS4","resource":"NDUFS4","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 5","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The human NADH: ubiquinone oxidoreductase NDUFS5 (15 kDa) subunit: cDNA cloning, chromosomal localization, tissue distribution and the absence of mutations in isolated complex I-deficient patients.","authors":["Loeffen J"," Smeets R"," Smeitink J"," Triepels R"," Sengers R"," Trijbels F"," van den Heuvel L."],"journal":"Journal of inherited metabolic disease","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10070614","id":"10070614","citationCount":3,"stringAuthors":"Loeffen J,  Smeets R,  Smeitink J,  Triepels R,  Sengers R,  Trijbels F,  van den Heuvel L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10070614","resource":"10070614","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS5","resource":"NDUFS5","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS6","resource":"NDUFS6","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone.","authors":["Schuler F"," Yano T"," Di Bernardo S"," Yagi T"," Yankovskaya V"," Singer TP"," Casida JE."],"journal":"Proceedings of the National Academy of Sciences of the United States of America","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10097178","id":"10097178","citationCount":51,"stringAuthors":"Schuler F,  Yano T,  Di Bernardo S,  Yagi T,  Yankovskaya V,  Singer TP,  Casida JE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10097178","resource":"10097178","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Assignment of the PSST subunit gene of human mitochondrial complex I to chromosome 19p13.","authors":["Hyslop SJ"," Duncan AM"," Pitkänen S"," Robinson BH."],"journal":"Genomics","year":1996,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8938450","id":"8938450","citationCount":8,"stringAuthors":"Hyslop SJ,  Duncan AM,  Pitkänen S,  Robinson BH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8938450","resource":"8938450","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Intimate relationships of the large and the small subunits of all nickel hydrogenases with two nuclear-encoded subunits of mitochondrial NADH: ubiquinone oxidoreductase.","authors":["Albracht SP."],"journal":"Biochimica et biophysica acta","year":1993,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8369340","id":"8369340","citationCount":22,"stringAuthors":"Albracht SP."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8369340","resource":"8369340","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS7","resource":"NDUFS7","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Learning from hydrogenases: location of a proton pump and of a second FMN in bovine NADH--ubiquinone oxidoreductase (Complex I).","authors":["Albracht SP"," Hedderich R."],"journal":"FEBS letters","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11086155","id":"11086155","citationCount":29,"stringAuthors":"Albracht SP,  Hedderich R."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11086155","resource":"11086155","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The first nuclear-encoded complex I mutation in a patient with Leigh syndrome.","authors":["Loeffen J"," Smeitink J"," Triepels R"," Smeets R"," Schuelke M"," Sengers R"," Trijbels F"," Hamel B"," Mullaart R"," van den Heuvel L."],"journal":"American journal of human genetics","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9837812","id":"9837812","citationCount":101,"stringAuthors":"Loeffen J,  Smeitink J,  Triepels R,  Smeets R,  Schuelke M,  Sengers R,  Trijbels F,  Hamel B,  Mullaart R,  van den Heuvel L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9837812","resource":"9837812","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Association of ferredoxin-NADP oxidoreductase with the chloroplastic pyridine nucleotide dehydrogenase complex in barley leaves","authors":["Jose Quiles M"," Cuello J."],"journal":"Plant physiology","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9576793","id":"9576793","citationCount":23,"stringAuthors":"Jose Quiles M,  Cuello J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9576793","resource":"9576793","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS8","resource":"NDUFS8","type":"HGNC_SYMBOL"}]},{"name":"NADH-cytochrome b5 reductase 3","references":[{"annotatorClassName":"","article":{"title":"Expression and characterization of a functional canine variant of cytochrome b5 reductase.","authors":["Roma GW"," Crowley LJ"," Barber MJ."],"journal":"Archives of biochemistry and biophysics","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16814740","id":"16814740","citationCount":5,"stringAuthors":"Roma GW,  Crowley LJ,  Barber MJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16814740","resource":"16814740","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A novel mutation of the cytochrome-b5 reductase gene in an Indian patient: the molecular basis of type I methemoglobinemia.","authors":["Nussenzveig RH"," Lingam HB"," Gaikwad A"," Zhu Q"," Jing N"," Prchal JT."],"journal":"Haematologica","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17082011","id":"17082011","citationCount":9,"stringAuthors":"Nussenzveig RH,  Lingam HB,  Gaikwad A,  Zhu Q,  Jing N,  Prchal JT."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17082011","resource":"17082011","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Structure of Physarum polycephalum cytochrome b5 reductase at 1.56 A resolution.","authors":["Kim S"," Suga M"," Ogasahara K"," Ikegami T"," Minami Y"," Yubisui T"," Tsukihara T."],"journal":"Acta crystallographica. Section F, Structural biology and crystallization communications","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17401193","id":"17401193","citationCount":3,"stringAuthors":"Kim S,  Suga M,  Ogasahara K,  Ikegami T,  Minami Y,  Yubisui T,  Tsukihara T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17401193","resource":"17401193","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Reductive detoxification of arylhydroxylamine carcinogens by human NADH cytochrome b5 reductase and cytochrome b5.","authors":["Kurian JR"," Chin NA"," Longlais BJ"," Hayes KL"," Trepanier LA."],"journal":"Chemical research in toxicology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17040106","id":"17040106","citationCount":14,"stringAuthors":"Kurian JR,  Chin NA,  Longlais BJ,  Hayes KL,  Trepanier LA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17040106","resource":"17040106","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Structure and properties of the recombinant NADH-cytochrome b5 reductase of Physarum polycephalum.","authors":["Ikegami T"," Kameyama E"," Yamamoto SY"," Minami Y"," Yubisui T."],"journal":"Bioscience, biotechnology, and biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17341833","id":"17341833","citationCount":1,"stringAuthors":"Ikegami T,  Kameyama E,  Yamamoto SY,  Minami Y,  Yubisui T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17341833","resource":"17341833","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=CYB5R3","resource":"CYB5R3","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS1","resource":"NDUFS1","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"TTD: Therapeutic Target Database.","authors":["Chen X"," Ji ZL"," Chen YZ."],"journal":"Nucleic acids research","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","id":"11752352","citationCount":104,"stringAuthors":"Chen X,  Ji ZL,  Chen YZ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","resource":"11752352","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND1","resource":"MT-ND1","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Differences in activity of cytochrome C oxidase in brain between sleep and wakefulness.","authors":["Nikonova EV"," Vijayasarathy C"," Zhang L"," Cater JR"," Galante RJ"," Ward SE"," Avadhani NG"," Pack AI."],"journal":"Sleep","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15700717","id":"15700717","citationCount":14,"stringAuthors":"Nikonova EV,  Vijayasarathy C,  Zhang L,  Cater JR,  Galante RJ,  Ward SE,  Avadhani NG,  Pack AI."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15700717","resource":"15700717","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"[The changes of gene expression in multiple myeloma treated with thalidomide].","authors":["Zhang HB"," Chen SL"," Liu JZ"," Xiao B"," Chen ZB"," Wang HJ."],"journal":"Zhonghua nei ke za zhi","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12882707","id":"12882707","citationCount":0,"stringAuthors":"Zhang HB,  Chen SL,  Liu JZ,  Xiao B,  Chen ZB,  Wang HJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12882707","resource":"12882707","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"TTD: Therapeutic Target Database.","authors":["Chen X"," Ji ZL"," Chen YZ."],"journal":"Nucleic acids research","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","id":"11752352","citationCount":104,"stringAuthors":"Chen X,  Ji ZL,  Chen YZ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","resource":"11752352","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND2","resource":"MT-ND2","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"TTD: Therapeutic Target Database.","authors":["Chen X"," Ji ZL"," Chen YZ."],"journal":"Nucleic acids research","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","id":"11752352","citationCount":104,"stringAuthors":"Chen X,  Ji ZL,  Chen YZ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","resource":"11752352","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND3","resource":"MT-ND3","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells.","authors":["Shen XY"," Zacal N"," Singh G"," Rainbow AJ."],"journal":"Photochemistry and photobiology","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15560738","id":"15560738","citationCount":16,"stringAuthors":"Shen XY,  Zacal N,  Singh G,  Rainbow AJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15560738","resource":"15560738","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Oxidative stress induces differential gene expression in a human lens epithelial cell line.","authors":["Carper DA"," Sun JK"," Iwata T"," Zigler JS"," Ibaraki N"," Lin LR"," Reddy V."],"journal":"Investigative ophthalmology & visual science","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9950599","id":"9950599","citationCount":21,"stringAuthors":"Carper DA,  Sun JK,  Iwata T,  Zigler JS,  Ibaraki N,  Lin LR,  Reddy V."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9950599","resource":"9950599","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Deletion of the structural gene for the NADH-dehydrogenase subunit 4 of Synechocystis 6803 alters respiratory properties.","authors":["Dzelzkalns VA"," Obinger C"," Regelsberger G"," Niederhauser H"," Kamensek M"," Peschek GA"," Bogorad L."],"journal":"Plant physiology","year":1994,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7846157","id":"7846157","citationCount":7,"stringAuthors":"Dzelzkalns VA,  Obinger C,  Regelsberger G,  Niederhauser H,  Kamensek M,  Peschek GA,  Bogorad L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7846157","resource":"7846157","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND4","resource":"MT-ND4","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 4L","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND4L","resource":"MT-ND4L","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 5","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Phylogenetic reconstruction of the Felidae using 16S rRNA and NADH-5 mitochondrial genes.","authors":["Johnson WE"," O'Brien SJ."],"journal":"Journal of molecular evolution","year":1997,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9071018","id":"9071018","citationCount":41,"stringAuthors":"Johnson WE,  O'Brien SJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9071018","resource":"9071018","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Association of MT-ND5 gene variation with mitochondrial respiratory control ratio and NADH dehydrogenase activity in Tibet chicken embryos.","authors":["Bao HG"," Zhao CJ"," Li JY"," Wu Ch."],"journal":"Animal genetics","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17614984","id":"17614984","citationCount":3,"stringAuthors":"Bao HG,  Zhao CJ,  Li JY,  Wu Ch."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17614984","resource":"17614984","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND5","resource":"MT-ND5","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 6","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND6","resource":"MT-ND6","type":"HGNC_SYMBOL"}]},{"name":"NADP-dependent malic enzyme","references":[{"annotatorClassName":"","article":{"title":"Determining Actinobacillus succinogenes metabolic pathways and fluxes by NMR and GC-MS analyses of 13C-labeled metabolic product isotopomers.","authors":["McKinlay JB"," Shachar-Hill Y"," Zeikus JG"," Vieille C."],"journal":"Metabolic engineering","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17197218","id":"17197218","citationCount":52,"stringAuthors":"McKinlay JB,  Shachar-Hill Y,  Zeikus JG,  Vieille C."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17197218","resource":"17197218","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ME1","resource":"ME1","type":"HGNC_SYMBOL"}]},{"name":"NADP-dependent malic enzyme, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates.","authors":["Luo C"," Wang X"," Long J"," Liu J."],"journal":"Journal of biochemical and biophysical methods","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16740313","id":"16740313","citationCount":9,"stringAuthors":"Luo C,  Wang X,  Long J,  Liu J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16740313","resource":"16740313","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Identification of cold acclimation-responsive Rhododendron genes for lipid metabolism, membrane transport and lignin biosynthesis: importance of moderately abundant ESTs in genomic studies.","authors":["Wei H"," Dhanaraj AL"," Arora R"," Rowland LJ"," Fu Y"," Sun L."],"journal":"Plant, cell & environment","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17080607","id":"17080607","citationCount":21,"stringAuthors":"Wei H,  Dhanaraj AL,  Arora R,  Rowland LJ,  Fu Y,  Sun L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17080607","resource":"17080607","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"L-2-hydroxyglutaric aciduria, a defect of metabolite repair.","authors":["Rzem R"," Vincent MF"," Van Schaftingen E"," Veiga-da-Cunha M."],"journal":"Journal of inherited metabolic disease","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17603759","id":"17603759","citationCount":52,"stringAuthors":"Rzem R,  Vincent MF,  Van Schaftingen E,  Veiga-da-Cunha M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17603759","resource":"17603759","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ME3","resource":"ME3","type":"HGNC_SYMBOL"}]},{"name":"Peroxisomal bifunctional enzyme","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=EHHADH","resource":"EHHADH","type":"HGNC_SYMBOL"}]},{"name":"Peroxisomal multifunctional enzyme type 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Binary structure of the two-domain (3R)-hydroxyacyl-CoA dehydrogenase from rat peroxisomal multifunctional enzyme type 2 at 2.38 A resolution.","authors":["Haapalainen AM"," Koski MK"," Qin YM"," Hiltunen JK"," Glumoff T."],"journal":"Structure (London, England : 1993)","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12517343","id":"12517343","citationCount":21,"stringAuthors":"Haapalainen AM,  Koski MK,  Qin YM,  Hiltunen JK,  Glumoff T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12517343","resource":"12517343","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B4","resource":"HSD17B4","type":"HGNC_SYMBOL"}]},{"name":"Pyrroline-5-carboxylate reductase 1, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Glutamine synthetase and glutamate dehydrogenase contribute differentially to proline accumulation in leaves of wheat (Triticum aestivum) seedlings exposed to different salinity.","authors":["Wang ZQ"," Yuan YZ"," Ou JQ"," Lin QH"," Zhang CF."],"journal":"Journal of plant physiology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16777263","id":"16777263","citationCount":33,"stringAuthors":"Wang ZQ,  Yuan YZ,  Ou JQ,  Lin QH,  Zhang CF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16777263","resource":"16777263","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Plant P5C reductase as a new target for aminomethylenebisphosphonates.","authors":["Forlani G"," Giberti S"," Berlicki L"," Petrollino D"," Kafarski P."],"journal":"Journal of agricultural and food chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17474756","id":"17474756","citationCount":13,"stringAuthors":"Forlani G,  Giberti S,  Berlicki L,  Petrollino D,  Kafarski P."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17474756","resource":"17474756","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PYCR1","resource":"PYCR1","type":"HGNC_SYMBOL"}]},{"name":"Pyrroline-5-carboxylate reductase 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Purification and characterization of Delta(1)-pyrroline-5-carboxylate reductase isoenzymes, indicating differential distribution in spinach (Spinacia oleracea L.) leaves.","authors":["Murahama M"," Yoshida T"," Hayashi F"," Ichino T"," Sanada Y"," Wada K."],"journal":"Plant & cell physiology","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11479381","id":"11479381","citationCount":15,"stringAuthors":"Murahama M,  Yoshida T,  Hayashi F,  Ichino T,  Sanada Y,  Wada K."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11479381","resource":"11479381","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PYCR2","resource":"PYCR2","type":"HGNC_SYMBOL"}]},{"name":"Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PDHA1","resource":"PDHA1","type":"HGNC_SYMBOL"}]},{"name":"Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PDHA2","resource":"PDHA2","type":"HGNC_SYMBOL"}]},{"name":"Pyruvate dehydrogenase E1 component subunit beta, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Regulation of pyruvate dehydrogenase in isolated rat liver mitochondria. Effects of octanoate, oxidation-reduction state, and adenosine triphosphate to adenosine diphosphate ratio.","authors":["Taylor SI"," Mukherjee C"," Jungas RL."],"journal":"The Journal of biological chemistry","year":1975,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1116996","id":"1116996","citationCount":34,"stringAuthors":"Taylor SI,  Mukherjee C,  Jungas RL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1116996","resource":"1116996","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PDHB","resource":"PDHB","type":"HGNC_SYMBOL"}]},{"name":"Retinal dehydrogenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Activities of cytosolic aldehyde dehydrogenase isozymes in colon cancer: determination using selective, fluorimetric assays.","authors":["WroczyÅ„ski P"," Nowak M"," Wierzchowski J"," Szubert A"," PolaÅ„ski J."],"journal":"Acta poloniae pharmaceutica","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16583981","id":"16583981","citationCount":3,"stringAuthors":"WroczyÅ„ski P,  Nowak M,  Wierzchowski J,  Szubert A,  PolaÅ„ski J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16583981","resource":"16583981","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal.","authors":["Russo J"," Barnes A"," Berger K"," Desgrosellier J"," Henderson J"," Kanters A"," Merkov L."],"journal":"BMC pharmacology","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11872149","id":"11872149","citationCount":10,"stringAuthors":"Russo J,  Barnes A,  Berger K,  Desgrosellier J,  Henderson J,  Kanters A,  Merkov L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11872149","resource":"11872149","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH1A1","resource":"ALDH1A1","type":"HGNC_SYMBOL"}]},{"name":"Retinal dehydrogenase 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The structure of retinal dehydrogenase type II at 2.7 A resolution: implications for retinal specificity.","authors":["Lamb AL"," Newcomer ME."],"journal":"Biochemistry","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10320326","id":"10320326","citationCount":51,"stringAuthors":"Lamb AL,  Newcomer ME."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10320326","resource":"10320326","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal.","authors":["Russo J"," Barnes A"," Berger K"," Desgrosellier J"," Henderson J"," Kanters A"," Merkov L."],"journal":"BMC pharmacology","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11872149","id":"11872149","citationCount":10,"stringAuthors":"Russo J,  Barnes A,  Berger K,  Desgrosellier J,  Henderson J,  Kanters A,  Merkov L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11872149","resource":"11872149","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH1A2","resource":"ALDH1A2","type":"HGNC_SYMBOL"}]},{"name":"Ribosyldihydronicotinamide dehydrogenase [quinone]","references":[{"annotatorClassName":"","article":{"title":"Reduction of mitomycin C is catalysed by human recombinant NRH:quinone oxidoreductase 2 using reduced nicotinamide adenine dinucleotide as an electron donating co-factor.","authors":["Jamieson D"," Tung AT"," Knox RJ"," Boddy AV."],"journal":"British journal of cancer","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17031400","id":"17031400","citationCount":12,"stringAuthors":"Jamieson D,  Tung AT,  Knox RJ,  Boddy AV."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17031400","resource":"17031400","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NQO1 and NQO2 regulation of humoral immunity and autoimmunity.","authors":["Iskander K"," Li J"," Han S"," Zheng B"," Jaiswal AK."],"journal":"The Journal of biological chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16905546","id":"16905546","citationCount":28,"stringAuthors":"Iskander K,  Li J,  Han S,  Zheng B,  Jaiswal AK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16905546","resource":"16905546","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NQO2","resource":"NQO2","type":"HGNC_SYMBOL"}]},{"name":"Short-chain specific acyl-CoA dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ACADS","resource":"ACADS","type":"HGNC_SYMBOL"}]},{"name":"Sorbitol dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"Pyridine nucleotide redox abnormalities in diabetes.","authors":["Ido Y."],"journal":"Antioxidants & redox signaling","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","id":"17508915","citationCount":36,"stringAuthors":"Ido Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","resource":"17508915","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase.","authors":["Klimacek M"," Hellmer H"," Nidetzky B."],"journal":"The Biochemical journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17343568","id":"17343568","citationCount":8,"stringAuthors":"Klimacek M,  Hellmer H,  Nidetzky B."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17343568","resource":"17343568","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SORD","resource":"SORD","type":"HGNC_SYMBOL"}]},{"name":"Steroid 17-alpha-hydroxylase/17,20 lyase","references":[{"annotatorClassName":"","article":{"title":"Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase.","authors":["Pandey AV"," Kempná P"," Hofer G"," Mullis PE"," Flück CE."],"journal":"Molecular endocrinology (Baltimore, Md.)","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17595315","id":"17595315","citationCount":49,"stringAuthors":"Pandey AV,  Kempná P,  Hofer G,  Mullis PE,  Flück CE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17595315","resource":"17595315","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=CYP17A1","resource":"CYP17A1","type":"HGNC_SYMBOL"}]},{"name":"Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Changes in gene expression associated with loss of function of the NSDHL sterol dehydrogenase in mouse embryonic fibroblasts.","authors":["Cunningham D"," Swartzlander D"," Liyanarachchi S"," Davuluri RV"," Herman GE."],"journal":"Journal of Lipid Research","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15805545","id":"15805545","citationCount":8,"stringAuthors":"Cunningham D,  Swartzlander D,  Liyanarachchi S,  Davuluri RV,  Herman GE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15805545","resource":"15805545","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NSDHL","resource":"NSDHL","type":"HGNC_SYMBOL"}]},{"name":"Succinate-semialdehyde dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH5A1","resource":"ALDH5A1","type":"HGNC_SYMBOL"}]},{"name":"Testosterone 17-beta-dehydrogenase 3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Relationship between steroids and pyridine nucleotides in the oxido-reduction catalyzed by the 17 beta-hydroxysteroid dehydrogenase purified from the porcine testicular microsomal fraction.","authors":["Inano H"," Tamaoki B."],"journal":"European journal of biochemistry","year":1975,"link":"http://www.ncbi.nlm.nih.gov/pubmed/237755","id":"237755","citationCount":9,"stringAuthors":"Inano H,  Tamaoki B."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/237755","resource":"237755","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B3","resource":"HSD17B3","type":"HGNC_SYMBOL"}]},{"name":"Trifunctional enzyme subunit alpha, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HADHA","resource":"HADHA","type":"HGNC_SYMBOL"}]},{"name":"Tyrosinase","references":[{"annotatorClassName":"","article":{"title":"Decolourization of azo dye methyl red by Saccharomyces cerevisiae MTCC 463.","authors":["Jadhav JP"," Parshetti GK"," Kalme SD"," Govindwar SP."],"journal":"Chemosphere","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17292452","id":"17292452","citationCount":47,"stringAuthors":"Jadhav JP,  Parshetti GK,  Kalme SD,  Govindwar SP."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17292452","resource":"17292452","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A potential role for cyclized quinones derived from dopamine, DOPA, and 3,4-dihydroxyphenylacetic acid in proteasomal inhibition.","authors":["Zafar KS"," Siegel D"," Ross D."],"journal":"Molecular pharmacology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16790533","id":"16790533","citationCount":38,"stringAuthors":"Zafar KS,  Siegel D,  Ross D."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16790533","resource":"16790533","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=TYR","resource":"TYR","type":"HGNC_SYMBOL"}]},{"name":"UDP-glucose 6-dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Regulatory mechanisms of UDP-glucuronic acid biosynthesis in cultured human skin fibroblasts.","authors":["Castellani AA"," De Luca G"," Rindi S"," Salvini R"," Tira ME."],"journal":"The Italian journal of biochemistry","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3804697","id":"3804697","citationCount":2,"stringAuthors":"Castellani AA,  De Luca G,  Rindi S,  Salvini R,  Tira ME."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3804697","resource":"3804697","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Mechanism of cadmium-decreased glucuronidation in the rat.","authors":["Alary J"," Cravedi JP"," Baradat M"," Carrera G."],"journal":"Biochemical pharmacology","year":1992,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1472079","id":"1472079","citationCount":3,"stringAuthors":"Alary J,  Cravedi JP,  Baradat M,  Carrera G."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1472079","resource":"1472079","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=UGDH","resource":"UGDH","type":"HGNC_SYMBOL"}]}]}]
\ No newline at end of file
+[{"bloodBrainBarrier":"YES","brandNames":[],"description":"NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). It forms NADP with the addition of a phosphate group to the 2' position of the adenosyl nucleotide through an ester linkage. (Dorland, 27th ed) ","id":"NADH","name":"NADH","references":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.drugbank.ca/drugs/DB00157","resource":"DB00157","type":"DRUGBANK"}],"synonyms":[],"targets":[{"name":"D-beta-hydroxybutyrate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A chemiluminescence-flow injection analysis of serum 3-hydroxybutyrate using a bioreactor consisting of 3-hydroxybutyrate dehydrogenase and NADH oxidase.","authors":["Tabata M"," Totani M."],"journal":"Analytical biochemistry","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8533882","id":"8533882","citationCount":5,"stringAuthors":"Tabata M,  Totani M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8533882","resource":"8533882","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Coenzyme binding by 3-hydroxybutyrate dehydrogenase, a lipid-requiring enzyme: lecithin acts as an allosteric modulator to enhance the affinity for coenzyme.","authors":["Rudy B"," Dubois H"," Mink R"," Trommer WE"," McIntyre JO"," Fleischer S."],"journal":"Biochemistry","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2550053","id":"2550053","citationCount":8,"stringAuthors":"Rudy B,  Dubois H,  Mink R,  Trommer WE,  McIntyre JO,  Fleischer S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2550053","resource":"2550053","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Activities of NAD-specific and NADP-specific isocitrate dehydrogenases in rat-liver mitochondria. Studies with D-threo-alpha-methylisocitrate.","authors":["Smith CM"," Plaut GW."],"journal":"European journal of biochemistry","year":1979,"link":"http://www.ncbi.nlm.nih.gov/pubmed/38961","id":"38961","citationCount":11,"stringAuthors":"Smith CM,  Plaut GW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/38961","resource":"38961","type":"PUBMED"}],"targetElements":[{"id":436152,"modelId":20637,"type":"ALIAS"}],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=BDH1","resource":"BDH1","type":"HGNC_SYMBOL"}]},{"name":"11-cis retinol dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"Analysis of the NADH-dependent retinaldehyde reductase activity of amphioxus retinol dehydrogenase enzymes enhances our understanding of the evolution of the retinol dehydrogenase family.","authors":["Dalfó D"," Marqués N"," Albalat R."],"journal":"The FEBS journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17608724","id":"17608724","citationCount":10,"stringAuthors":"Dalfó D,  Marqués N,  Albalat R."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17608724","resource":"17608724","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=RDH5","resource":"RDH5","type":"HGNC_SYMBOL"}]},{"name":"15-hydroxyprostaglandin dehydrogenase [NAD(+)]","references":[{"annotatorClassName":"","article":{"title":"Corticotropin-releasing hormone receptor type 1 and type 2 mediate differential effects on 15-hydroxy prostaglandin dehydrogenase expression in cultured human chorion trophoblasts.","authors":["Gao L"," He P"," Sha J"," Liu C"," Dai L"," Hui N"," Ni X."],"journal":"Endocrinology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17463062","id":"17463062","citationCount":10,"stringAuthors":"Gao L,  He P,  Sha J,  Liu C,  Dai L,  Hui N,  Ni X."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17463062","resource":"17463062","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HPGD","resource":"HPGD","type":"HGNC_SYMBOL"}]},{"name":"2-oxoglutarate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"The tricarboxylic acid cycle, an ancient metabolic network with a novel twist.","authors":["Mailloux RJ"," Bériault R"," Lemire J"," Singh R"," Chénier DR"," Hamel RD"," Appanna VD."],"journal":"PloS one","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17668068","id":"17668068","citationCount":101,"stringAuthors":"Mailloux RJ,  Bériault R,  Lemire J,  Singh R,  Chénier DR,  Hamel RD,  Appanna VD."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17668068","resource":"17668068","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=OGDH","resource":"OGDH","type":"HGNC_SYMBOL"}]},{"name":"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of testosterone biosynthesis by ethanol: multiple sites and mechanisms in dispersed Leydig cells.","authors":["Widenius TV"," Orava MM"," Vihko RK"," Ylikahri RH"," Eriksson CJ."],"journal":"Journal of steroid biochemistry","year":1987,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3476810","id":"3476810","citationCount":14,"stringAuthors":"Widenius TV,  Orava MM,  Vihko RK,  Ylikahri RH,  Eriksson CJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3476810","resource":"3476810","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Affinity alkylation of human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase by 2 alpha-bromoacetoxyprogesterone: evidence for separate dehydrogenase and isomerase sites on one protein.","authors":["Thomas JL"," Myers RP"," Rosik LO"," Strickler RC."],"journal":"Journal of steroid biochemistry","year":1990,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2362440","id":"2362440","citationCount":4,"stringAuthors":"Thomas JL,  Myers RP,  Rosik LO,  Strickler RC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2362440","resource":"2362440","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Testicular and adrenal 3 beta-hydroxy-5-ene-steroid dehydrogenase and 5-ene-4-ene isomerase.","authors":["Ishii-Ohba H"," Inano H"," Tamaoki B."],"journal":"Journal of steroid biochemistry","year":1987,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2961942","id":"2961942","citationCount":10,"stringAuthors":"Ishii-Ohba H,  Inano H,  Tamaoki B."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2961942","resource":"2961942","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD3B1","resource":"HSD3B1","type":"HGNC_SYMBOL"}]},{"name":"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of testosterone biosynthesis by ethanol: multiple sites and mechanisms in dispersed Leydig cells.","authors":["Widenius TV"," Orava MM"," Vihko RK"," Ylikahri RH"," Eriksson CJ."],"journal":"Journal of steroid biochemistry","year":1987,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3476810","id":"3476810","citationCount":14,"stringAuthors":"Widenius TV,  Orava MM,  Vihko RK,  Ylikahri RH,  Eriksson CJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3476810","resource":"3476810","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Studies of the human testis. VII. Conversion of pregnenolone to progesterone.","authors":["Fan DF"," Troen P."],"journal":"The Journal of clinical endocrinology and metabolism","year":1975,"link":"http://www.ncbi.nlm.nih.gov/pubmed/239964","id":"239964","citationCount":8,"stringAuthors":"Fan DF,  Troen P."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/239964","resource":"239964","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Analysis of coenzyme binding by human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase using 5'-[p-(fluorosulfonyl)benzoyl]adenosine, an affinity labeling cofactor analog.","authors":["Thomas JL"," Myers RP"," Strickler RC."],"journal":"The Journal of steroid biochemistry and molecular biology","year":1991,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1911436","id":"1911436","citationCount":3,"stringAuthors":"Thomas JL,  Myers RP,  Strickler RC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1911436","resource":"1911436","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD3B2","resource":"HSD3B2","type":"HGNC_SYMBOL"}]},{"name":"3-hydroxy-3-methylglutaryl-coenzyme A reductase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Improved posthypoxic recovery in vitro on treatment with drugs used for secondary stroke prevention.","authors":["Huber R"," Riepe MW."],"journal":"Neuropharmacology","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15755483","id":"15755483","citationCount":1,"stringAuthors":"Huber R,  Riepe MW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15755483","resource":"15755483","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii.","authors":["Hedl M"," Rodwell VW."],"journal":"Protein science : a publication of the Protein Society","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15152097","id":"15152097","citationCount":10,"stringAuthors":"Hedl M,  Rodwell VW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15152097","resource":"15152097","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"3-hydroxy-3-methylglutaryl-coenzyme A reductase in the lobster mandibular organ: regulation by the eyestalk.","authors":["Li S"," Wagner CA"," Friesen JA"," Borst DW."],"journal":"General and comparative endocrinology","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14511985","id":"14511985","citationCount":13,"stringAuthors":"Li S,  Wagner CA,  Friesen JA,  Borst DW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14511985","resource":"14511985","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HMGCR","resource":"HMGCR","type":"HGNC_SYMBOL"}]},{"name":"3-hydroxyacyl-CoA dehydrogenase type-2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B10","resource":"HSD17B10","type":"HGNC_SYMBOL"}]},{"name":"3-hydroxyisobutyrate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HIBADH","resource":"HIBADH","type":"HGNC_SYMBOL"}]},{"name":"3-keto-steroid reductase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B7","resource":"HSD17B7","type":"HGNC_SYMBOL"}]},{"name":"4-trimethylaminobutyraldehyde dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Properties of gamma-aminobutyraldehyde dehydrogenase from Escherichia coli.","authors":["Prieto MI"," Martin J"," Balaña-Fouce R"," Garrido-Pertierra A."],"journal":"Biochimie","year":1987,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3129020","id":"3129020","citationCount":5,"stringAuthors":"Prieto MI,  Martin J,  Balaña-Fouce R,  Garrido-Pertierra A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3129020","resource":"3129020","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Purification and kinetic characterization of gamma-aminobutyraldehyde dehydrogenase from rat liver.","authors":["Testore G"," Colombatto S"," Silvagno F"," Bedino S."],"journal":"The international journal of biochemistry & cell biology","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7584606","id":"7584606","citationCount":4,"stringAuthors":"Testore G,  Colombatto S,  Silvagno F,  Bedino S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7584606","resource":"7584606","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH9A1","resource":"ALDH9A1","type":"HGNC_SYMBOL"}]},{"name":"7-dehydrocholesterol reductase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DHCR7","resource":"DHCR7","type":"HGNC_SYMBOL"}]},{"name":"Acyl carrier protein, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFAB1","resource":"NDUFAB1","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase 1A","references":[{"annotatorClassName":"","article":{"title":"Synthetic lethal and biochemical analyses of NAD and NADH kinases in Saccharomyces cerevisiae establish separation of cellular functions.","authors":["Bieganowski P"," Seidle HF"," Wojcik M"," Brenner C."],"journal":"The Journal of biological chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16760478","id":"16760478","citationCount":25,"stringAuthors":"Bieganowski P,  Seidle HF,  Wojcik M,  Brenner C."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16760478","resource":"16760478","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Two highly divergent alcohol dehydrogenases of melon exhibit fruit ripening-specific expression and distinct biochemical characteristics.","authors":["Manríquez D"," El-Sharkawy I"," Flores FB"," El-Yahyaoui F"," Regad F"," Bouzayen M"," Latché A"," Pech JC."],"journal":"Plant molecular biology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16897483","id":"16897483","citationCount":34,"stringAuthors":"Manríquez D,  El-Sharkawy I,  Flores FB,  El-Yahyaoui F,  Regad F,  Bouzayen M,  Latché A,  Pech JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16897483","resource":"16897483","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH1A","resource":"ADH1A","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase 1B","references":[{"annotatorClassName":"","article":{"title":"Two highly divergent alcohol dehydrogenases of melon exhibit fruit ripening-specific expression and distinct biochemical characteristics.","authors":["Manríquez D"," El-Sharkawy I"," Flores FB"," El-Yahyaoui F"," Regad F"," Bouzayen M"," Latché A"," Pech JC."],"journal":"Plant molecular biology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16897483","id":"16897483","citationCount":34,"stringAuthors":"Manríquez D,  El-Sharkawy I,  Flores FB,  El-Yahyaoui F,  Regad F,  Bouzayen M,  Latché A,  Pech JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16897483","resource":"16897483","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH1B","resource":"ADH1B","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase 1C","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Specificity of human alcohol dehydrogenase 1C*2 (gamma2gamma2) for steroids and simulation of the uncompetitive inhibition of ethanol metabolism.","authors":["Plapp BV"," Berst KB."],"journal":"Chemico-biological interactions","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12604203","id":"12604203","citationCount":3,"stringAuthors":"Plapp BV,  Berst KB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12604203","resource":"12604203","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH1C","resource":"ADH1C","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase 4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Biochemical basis of mitochondrial acetaldehyde dismutation in Saccharomyces cerevisiae.","authors":["Thielen J"," Ciriacy M."],"journal":"Journal of bacteriology","year":1991,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1938903","id":"1938903","citationCount":3,"stringAuthors":"Thielen J,  Ciriacy M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1938903","resource":"1938903","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Mouse alcohol dehydrogenase 4: kinetic mechanism, substrate specificity and simulation of effects of ethanol on retinoid metabolism.","authors":["Plapp BV"," Mitchell JL"," Berst KB."],"journal":"Chemico-biological interactions","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11306066","id":"11306066","citationCount":4,"stringAuthors":"Plapp BV,  Mitchell JL,  Berst KB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11306066","resource":"11306066","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Ethanol-induced inhibition of testosterone biosynthesis in vitro: lack of acetaldehyde effect.","authors":["Widenius TV."],"journal":"Alcohol and alcoholism (Oxford, Oxfordshire)","year":1987,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3593480","id":"3593480","citationCount":2,"stringAuthors":"Widenius TV."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3593480","resource":"3593480","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH4","resource":"ADH4","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase class 4 mu/sigma chain","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Analysis of the NADH-dependent retinaldehyde reductase activity of amphioxus retinol dehydrogenase enzymes enhances our understanding of the evolution of the retinol dehydrogenase family.","authors":["Dalfó D"," Marqués N"," Albalat R."],"journal":"The FEBS journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17608724","id":"17608724","citationCount":10,"stringAuthors":"Dalfó D,  Marqués N,  Albalat R."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17608724","resource":"17608724","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Identification and immunohistochemistry of retinol dehydrogenase from bovine retinal pigment epithelium.","authors":["Suzuki Y"," Ishiguro S"," Tamai M."],"journal":"Biochimica et biophysica acta","year":1993,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8490052","id":"8490052","citationCount":12,"stringAuthors":"Suzuki Y,  Ishiguro S,  Tamai M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8490052","resource":"8490052","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Effect of thyroid hormone on the alcohol dehydrogenase activities in rat tissues.","authors":["Kim DS"," Lee CB"," Park YS"," Ahn YH"," Kim TW"," Kee CS"," Kang JS"," Om AS."],"journal":"Journal of Korean medical science","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11410692","id":"11410692","citationCount":1,"stringAuthors":"Kim DS,  Lee CB,  Park YS,  Ahn YH,  Kim TW,  Kee CS,  Kang JS,  Om AS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11410692","resource":"11410692","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH7","resource":"ADH7","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase class-3","references":[{"annotatorClassName":"","article":{"title":"High-resolution structures of formate dehydrogenase from Candida boidinii.","authors":["Schirwitz K"," Schmidt A"," Lamzin VS."],"journal":"Protein science : a publication of the Protein Society","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17525463","id":"17525463","citationCount":24,"stringAuthors":"Schirwitz K,  Schmidt A,  Lamzin VS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17525463","resource":"17525463","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"D-mannitol production by resting state whole cell biotrans-formation of D-fructose by heterologous mannitol and formate dehydrogenase gene expression in Bacillus megaterium.","authors":["Bäumchen C"," Roth AH"," Biedendieck R"," Malten M"," Follmann M"," Sahm H"," Bringer-Meyer S"," Jahn D."],"journal":"Biotechnology journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17619232","id":"17619232","citationCount":11,"stringAuthors":"Bäumchen C,  Roth AH,  Biedendieck R,  Malten M,  Follmann M,  Sahm H,  Bringer-Meyer S,  Jahn D."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17619232","resource":"17619232","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Enhanced activity of 3alpha-hydroxysteroid dehydrogenase by addition of the co-solvent 1-butyl-3-methylimidazolium (L)-lactate in aqueous phase of biphasic systems for reductive production of steroids.","authors":["Okochi M"," Nakagawa I"," Kobayashi T"," Hayashi S"," Furusaki S"," Honda H."],"journal":"Journal of biotechnology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17092593","id":"17092593","citationCount":7,"stringAuthors":"Okochi M,  Nakagawa I,  Kobayashi T,  Hayashi S,  Furusaki S,  Honda H."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17092593","resource":"17092593","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Logic gates and elementary computing by enzymes.","authors":["Baron R"," Lioubashevski O"," Katz E"," Niazov T"," Willner I."],"journal":"The journal of physical chemistry. A","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16821840","id":"16821840","citationCount":36,"stringAuthors":"Baron R,  Lioubashevski O,  Katz E,  Niazov T,  Willner I."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16821840","resource":"16821840","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH5","resource":"ADH5","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase X, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH1B1","resource":"ALDH1B1","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase family 1 member A3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Characterization of retinaldehyde dehydrogenase 3.","authors":["Graham CE"," Brocklehurst K"," Pickersgill RW"," Warren MJ."],"journal":"The Biochemical journal","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16241904","id":"16241904","citationCount":17,"stringAuthors":"Graham CE,  Brocklehurst K,  Pickersgill RW,  Warren MJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16241904","resource":"16241904","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH1A3","resource":"ALDH1A3","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase family 3 member B1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH3B1","resource":"ALDH3B1","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase family 3 member B2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH3B2","resource":"ALDH3B2","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase, dimeric NADP-preferring","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Activities of cytosolic aldehyde dehydrogenase isozymes in colon cancer: determination using selective, fluorimetric assays.","authors":["WroczyÅ„ski P"," Nowak M"," Wierzchowski J"," Szubert A"," PolaÅ„ski J."],"journal":"Acta poloniae pharmaceutica","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16583981","id":"16583981","citationCount":3,"stringAuthors":"WroczyÅ„ski P,  Nowak M,  Wierzchowski J,  Szubert A,  PolaÅ„ski J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16583981","resource":"16583981","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH3A1","resource":"ALDH3A1","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective.","authors":["Quintanilla ME"," Tampier L"," Sapag A"," Gerdtzen Z"," Israel Y."],"journal":"American journal of physiology. Endocrinology and metabolism","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17488809","id":"17488809","citationCount":17,"stringAuthors":"Quintanilla ME,  Tampier L,  Sapag A,  Gerdtzen Z,  Israel Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17488809","resource":"17488809","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake.","authors":["Quintanilla ME"," Israel Y"," Sapag A"," Tampier L."],"journal":"Addiction biology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16961761","id":"16961761","citationCount":56,"stringAuthors":"Quintanilla ME,  Israel Y,  Sapag A,  Tampier L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16961761","resource":"16961761","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH2","resource":"ALDH2","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"Journal of steroid biochemistry","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","id":"2615366","citationCount":0,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","resource":"2615366","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Microsomal 20 alpha-hydroxysteroid dehydrogenase activity for progesterone in human placenta.","authors":["Fukuda T"," Hirato K"," Yanaihara T"," Nakayama T."],"journal":"Endocrinologia japonica","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","id":"3463506","citationCount":2,"stringAuthors":"Fukuda T,  Hirato K,  Yanaihara T,  Nakayama T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","resource":"3463506","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene.","authors":["Burczynski ME"," Sridhar GR"," Palackal NT"," Penning TM."],"journal":"The Journal of biological chemistry","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11060293","id":"11060293","citationCount":72,"stringAuthors":"Burczynski ME,  Sridhar GR,  Palackal NT,  Penning TM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11060293","resource":"11060293","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C1","resource":"AKR1C1","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells.","authors":["Rizner TL"," Lin HK"," Peehl DM"," Steckelbroeck S"," Bauman DR"," Penning TM."],"journal":"Endocrinology","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12810547","id":"12810547","citationCount":65,"stringAuthors":"Rizner TL,  Lin HK,  Peehl DM,  Steckelbroeck S,  Bauman DR,  Penning TM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12810547","resource":"12810547","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Kinetics of allopregnanolone formation catalyzed by human 3 alpha-hydroxysteroid dehydrogenase type III (AKR1C2).","authors":["Trauger JW"," Jiang A"," Stearns BA"," LoGrasso PV."],"journal":"Biochemistry","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12416991","id":"12416991","citationCount":40,"stringAuthors":"Trauger JW,  Jiang A,  Stearns BA,  LoGrasso PV."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12416991","resource":"12416991","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C2","resource":"AKR1C2","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"Journal of steroid biochemistry","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","id":"2615366","citationCount":0,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","resource":"2615366","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer between progesterone and cofactor by human placental estradiol-17 beta dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"The Journal of steroid biochemistry and molecular biology","year":1990,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2146972","id":"2146972","citationCount":0,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2146972","resource":"2146972","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Bioluminescent assay of femtomole levels of estrone and estradiol.","authors":["Nicolas JC"," Boussioux AM"," Boularan AM"," Descomps B"," Crastes de Paulet A."],"journal":"Analytical biochemistry","year":1983,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6584048","id":"6584048","citationCount":5,"stringAuthors":"Nicolas JC,  Boussioux AM,  Boularan AM,  Descomps B,  Crastes de Paulet A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6584048","resource":"6584048","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C3","resource":"AKR1C3","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Purification and characterization of oxidoreductases-catalyzing carbonyl reduction of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human liver cytosol.","authors":["Atalla A"," Breyer-Pfaff U"," Maser E."],"journal":"Xenobiotica; the fate of foreign compounds in biological systems","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11037109","id":"11037109","citationCount":29,"stringAuthors":"Atalla A,  Breyer-Pfaff U,  Maser E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11037109","resource":"11037109","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C4","resource":"AKR1C4","type":"HGNC_SYMBOL"}]},{"name":"Aldose reductase","references":[{"annotatorClassName":"","article":{"title":"Pyridine nucleotide redox abnormalities in diabetes.","authors":["Ido Y."],"journal":"Antioxidants & redox signaling","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","id":"17508915","citationCount":36,"stringAuthors":"Ido Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","resource":"17508915","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Vitamin C. Biosynthesis, recycling and degradation in mammals.","authors":["Linster CL"," Van Schaftingen E."],"journal":"The FEBS journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17222174","id":"17222174","citationCount":175,"stringAuthors":"Linster CL,  Van Schaftingen E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17222174","resource":"17222174","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1B1","resource":"AKR1B1","type":"HGNC_SYMBOL"}]},{"name":"Alpha-aminoadipic semialdehyde dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes.","authors":["de La Fuente JL"," Rumbero A"," Martín JF"," Liras P."],"journal":"The Biochemical journal","year":1997,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9355735","id":"9355735","citationCount":10,"stringAuthors":"de La Fuente JL,  Rumbero A,  Martín JF,  Liras P."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9355735","resource":"9355735","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH7A1","resource":"ALDH7A1","type":"HGNC_SYMBOL"}]},{"name":"Alpha-aminoadipic semialdehyde synthase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Determinants of substrate specificity for saccharopine dehydrogenase from Saccharomyces cerevisiae.","authors":["Xu H"," West AH"," Cook PF."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17542618","id":"17542618","citationCount":3,"stringAuthors":"Xu H,  West AH,  Cook PF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17542618","resource":"17542618","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Overall kinetic mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae.","authors":["Xu H"," West AH"," Cook PF."],"journal":"Biochemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17002315","id":"17002315","citationCount":12,"stringAuthors":"Xu H,  West AH,  Cook PF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17002315","resource":"17002315","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A proposed proton shuttle mechanism for saccharopine dehydrogenase from Saccharomyces cerevisiae.","authors":["Xu H"," Alguindigue SS"," West AH"," Cook PF."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17223709","id":"17223709","citationCount":9,"stringAuthors":"Xu H,  Alguindigue SS,  West AH,  Cook PF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17223709","resource":"17223709","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AASS","resource":"AASS","type":"HGNC_SYMBOL"}]},{"name":"Aminomethyltransferase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AMT","resource":"AMT","type":"HGNC_SYMBOL"}]},{"name":"Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MTHFD2","resource":"MTHFD2","type":"HGNC_SYMBOL"}]},{"name":"Biliverdin reductase A","references":[{"annotatorClassName":"","article":{"title":"Activation of biliverdin-IXalpha reductase by inorganic phosphate and related anions.","authors":["Franklin E"," Browne S"," Hayes J"," Boland C"," Dunne A"," Elliot G"," Mantle TJ."],"journal":"The Biochemical journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17402939","id":"17402939","citationCount":4,"stringAuthors":"Franklin E,  Browne S,  Hayes J,  Boland C,  Dunne A,  Elliot G,  Mantle TJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17402939","resource":"17402939","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=BLVRA","resource":"BLVRA","type":"HGNC_SYMBOL"}]},{"name":"C-1-tetrahydrofolate synthase, cytoplasmic","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MTHFD1","resource":"MTHFD1","type":"HGNC_SYMBOL"}]},{"name":"Corticosteroid 11-beta-dehydrogenase isozyme 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Metabolism of dexamethasone in the human kidney: nicotinamide adenine dinucleotide-dependent 11beta-reduction.","authors":["Diederich S"," Hanke B"," Oelkers W"," Bähr V."],"journal":"The Journal of Clinical Endocrinology and Metabolism","year":1997,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9141556","id":"9141556","citationCount":15,"stringAuthors":"Diederich S,  Hanke B,  Oelkers W,  Bähr V."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9141556","resource":"9141556","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Comparison of 11 beta-hydroxysteroid dehydrogenase in spontaneously hypertensive and Wistar-Kyoto rats.","authors":["Hermans JJ"," Steckel B"," Thijssen HH"," Janssen BJ"," Netter KJ"," Maser E."],"journal":"Steroids","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8585102","id":"8585102","citationCount":3,"stringAuthors":"Hermans JJ,  Steckel B,  Thijssen HH,  Janssen BJ,  Netter KJ,  Maser E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8585102","resource":"8585102","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD11B1","resource":"HSD11B1","type":"HGNC_SYMBOL"}]},{"name":"Corticosteroid 11-beta-dehydrogenase isozyme 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Localization of an 11 beta hydroxysteroid dehydrogenase activity to the distal nephron. Evidence for the existence of two species of dehydrogenase in the rat kidney.","authors":["Mercer WR"," Krozowski ZS."],"journal":"Endocrinology","year":1992,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1727721","id":"1727721","citationCount":62,"stringAuthors":"Mercer WR,  Krozowski ZS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1727721","resource":"1727721","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Comparison of 11 beta-hydroxysteroid dehydrogenase in spontaneously hypertensive and Wistar-Kyoto rats.","authors":["Hermans JJ"," Steckel B"," Thijssen HH"," Janssen BJ"," Netter KJ"," Maser E."],"journal":"Steroids","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8585102","id":"8585102","citationCount":3,"stringAuthors":"Hermans JJ,  Steckel B,  Thijssen HH,  Janssen BJ,  Netter KJ,  Maser E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8585102","resource":"8585102","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD11B2","resource":"HSD11B2","type":"HGNC_SYMBOL"}]},{"name":"Cysteine dioxygenase type 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=CDO1","resource":"CDO1","type":"HGNC_SYMBOL"}]},{"name":"Cytochrome P450 4A11","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cytochrome P450 4A, peroxisomal enzymes and nicotinamide cofactors in koala liver.","authors":["Ngo S"," Kong S"," Kirlich A"," McKinnon RA"," Stupans I."],"journal":"Comparative biochemistry and physiology. Toxicology & pharmacology : CBP","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11246504","id":"11246504","citationCount":6,"stringAuthors":"Ngo S,  Kong S,  Kirlich A,  McKinnon RA,  Stupans I."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11246504","resource":"11246504","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=CYP4A11","resource":"CYP4A11","type":"HGNC_SYMBOL"}]},{"name":"D-3-phosphoglycerate dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A new family of 2-hydroxyacid dehydrogenases.","authors":["Grant GA."],"journal":"Biochemical and biophysical research communications","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2692566","id":"2692566","citationCount":37,"stringAuthors":"Grant GA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2692566","resource":"2692566","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Serine biosynthesis in human hair follicles by the phosphorylated pathway: follicular 3-phosphoglycerate dehydrogenase.","authors":["Goldsmith LA"," O'Barr T."],"journal":"The Journal of investigative dermatology","year":1976,"link":"http://www.ncbi.nlm.nih.gov/pubmed/945314","id":"945314","citationCount":4,"stringAuthors":"Goldsmith LA,  O'Barr T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/945314","resource":"945314","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cofactor binding to Escherichia coli D-3-phosphoglycerate dehydrogenase induces multiple conformations which alter effector binding.","authors":["Grant GA"," Hu Z"," Xu XL."],"journal":"The Journal of biological chemistry","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12183470","id":"12183470","citationCount":9,"stringAuthors":"Grant GA,  Hu Z,  Xu XL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12183470","resource":"12183470","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PHGDH","resource":"PHGDH","type":"HGNC_SYMBOL"}]},{"name":"Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Crystal structure of Thermus thermophilus Delta1-pyrroline-5-carboxylate dehydrogenase.","authors":["Inagaki E"," Ohshima N"," Takahashi H"," Kuroishi C"," Yokoyama S"," Tahirov TH."],"journal":"Journal of molecular biology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16934832","id":"16934832","citationCount":35,"stringAuthors":"Inagaki E,  Ohshima N,  Takahashi H,  Kuroishi C,  Yokoyama S,  Tahirov TH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16934832","resource":"16934832","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH4A1","resource":"ALDH4A1","type":"HGNC_SYMBOL"}]},{"name":"Dihydrofolate reductase","references":[{"annotatorClassName":"","article":{"title":"Proteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis.","authors":["Argyrou A"," Jin L"," Siconilfi-Baez L"," Angeletti RH"," Blanchard JS."],"journal":"Biochemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17115689","id":"17115689","citationCount":38,"stringAuthors":"Argyrou A,  Jin L,  Siconilfi-Baez L,  Angeletti RH,  Blanchard JS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17115689","resource":"17115689","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence.","authors":["Vickers TJ"," Orsomando G"," de la Garza RD"," Scott DA"," Kang SO"," Hanson AD"," Beverley SM."],"journal":"The Journal of biological chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17032644","id":"17032644","citationCount":13,"stringAuthors":"Vickers TJ,  Orsomando G,  de la Garza RD,  Scott DA,  Kang SO,  Hanson AD,  Beverley SM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17032644","resource":"17032644","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DHFR","resource":"DHFR","type":"HGNC_SYMBOL"}]},{"name":"Dihydrolipoyl dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Histochemical staining and quantification of dihydrolipoamide dehydrogenase diaphorase activity using blue native PAGE.","authors":["Yan LJ"," Yang SH"," Shu H"," Prokai L"," Forster MJ."],"journal":"Electrophoresis","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17315258","id":"17315258","citationCount":25,"stringAuthors":"Yan LJ,  Yang SH,  Shu H,  Prokai L,  Forster MJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17315258","resource":"17315258","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Trypanosoma cruzi dihydrolipoamide dehydrogenase as target for phenothiazine cationic radicals. Effect of antioxidants.","authors":["Gutiérrez-Correa J."],"journal":"Current drug targets","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17017892","id":"17017892","citationCount":3,"stringAuthors":"Gutiérrez-Correa J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17017892","resource":"17017892","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A novel branched-chain amino acid metabolon. Protein-protein interactions in a supramolecular complex.","authors":["Islam MM"," Wallin R"," Wynn RM"," Conway M"," Fujii H"," Mobley JA"," Chuang DT"," Hutson SM."],"journal":"The Journal of biological chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17314104","id":"17314104","citationCount":32,"stringAuthors":"Islam MM,  Wallin R,  Wynn RM,  Conway M,  Fujii H,  Mobley JA,  Chuang DT,  Hutson SM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17314104","resource":"17314104","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DLD","resource":"DLD","type":"HGNC_SYMBOL"}]},{"name":"Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis.","authors":["Shi S"," Ehrt S."],"journal":"Infection and immunity","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16368957","id":"16368957","citationCount":40,"stringAuthors":"Shi S,  Ehrt S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16368957","resource":"16368957","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DLAT","resource":"DLAT","type":"HGNC_SYMBOL"}]},{"name":"Dihydropteridine reductase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Determination of NADPH-specific dihydropteridine reductase in extract from human, monkey, and bovine livers by single radial immunodiffusion: selective assay differentiating NADPH- and NADH-specific enzymes.","authors":["Nakanishi N"," Ozawa K"," Yamada S."],"journal":"Journal of biochemistry","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3086306","id":"3086306","citationCount":1,"stringAuthors":"Nakanishi N,  Ozawa K,  Yamada S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3086306","resource":"3086306","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Spectral studies of the interaction of the substrate 'quinonoid' 6-methyl dihydropterine and the coenzyme NADH used as marker in the dihydropteridine reductase assay.","authors":["van der Heiden C"," Brink W."],"journal":"Journal of inherited metabolic disease","year":1982,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6820434","id":"6820434","citationCount":0,"stringAuthors":"van der Heiden C,  Brink W."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6820434","resource":"6820434","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NADH-ferric reductase activity associated with dihydropteridine reductase.","authors":["Lee PL"," Halloran C"," Cross AR"," Beutler E."],"journal":"Biochemical and biophysical research communications","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10814540","id":"10814540","citationCount":3,"stringAuthors":"Lee PL,  Halloran C,  Cross AR,  Beutler E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10814540","resource":"10814540","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=QDPR","resource":"QDPR","type":"HGNC_SYMBOL"}]},{"name":"Estradiol 17-beta-dehydrogenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"Journal of steroid biochemistry","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","id":"2615366","citationCount":0,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","resource":"2615366","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Microsomal 20 alpha-hydroxysteroid dehydrogenase activity for progesterone in human placenta.","authors":["Fukuda T"," Hirato K"," Yanaihara T"," Nakayama T."],"journal":"Endocrinologia japonica","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","id":"3463506","citationCount":2,"stringAuthors":"Fukuda T,  Hirato K,  Yanaihara T,  Nakayama T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","resource":"3463506","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The 20 alpha-hydroxysteroid dehydrogenase of Streptomyces hydrogenans.","authors":["Rimsay RL"," Murphy GW"," Martin CJ"," Orr JC."],"journal":"European journal of biochemistry","year":1988,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3164265","id":"3164265","citationCount":1,"stringAuthors":"Rimsay RL,  Murphy GW,  Martin CJ,  Orr JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3164265","resource":"3164265","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B1","resource":"HSD17B1","type":"HGNC_SYMBOL"}]},{"name":"Estradiol 17-beta-dehydrogenase 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Microsomal 20 alpha-hydroxysteroid dehydrogenase activity for progesterone in human placenta.","authors":["Fukuda T"," Hirato K"," Yanaihara T"," Nakayama T."],"journal":"Endocrinologia japonica","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","id":"3463506","citationCount":2,"stringAuthors":"Fukuda T,  Hirato K,  Yanaihara T,  Nakayama T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","resource":"3463506","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"Journal of steroid biochemistry","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","id":"2615366","citationCount":0,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","resource":"2615366","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Prostaglandin-E2 9-reductase from corpus luteum of pseudopregnant rabbit is a member of the aldo-keto reductase superfamily featuring 20 alpha-hydroxysteroid dehydrogenase activity.","authors":["Wintergalen N"," Thole HH"," Galla HJ"," Schlegel W."],"journal":"European journal of biochemistry","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8529651","id":"8529651","citationCount":22,"stringAuthors":"Wintergalen N,  Thole HH,  Galla HJ,  Schlegel W."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8529651","resource":"8529651","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B2","resource":"HSD17B2","type":"HGNC_SYMBOL"}]},{"name":"Estradiol 17-beta-dehydrogenase 8","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B8","resource":"HSD17B8","type":"HGNC_SYMBOL"}]},{"name":"Fatty aldehyde dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Mechanism of a long-chain fatty aldehyde dehydrogenase induced during the development of bioluminescence in Beneckea harveyi.","authors":["Bognar A"," Meighen E."],"journal":"Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire","year":1983,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6603890","id":"6603890","citationCount":0,"stringAuthors":"Bognar A,  Meighen E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6603890","resource":"6603890","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH3A2","resource":"ALDH3A2","type":"HGNC_SYMBOL"}]},{"name":"Flavin reductase (NADPH)","references":[{"annotatorClassName":"","article":{"title":"Characterization of two components of the 2-naphthoate monooxygenase system from Burkholderia sp. strain JT1500.","authors":["Deng D"," Li X"," Fang X"," Sun G."],"journal":"FEMS microbiology letters","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17559398","id":"17559398","citationCount":1,"stringAuthors":"Deng D,  Li X,  Fang X,  Sun G."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17559398","resource":"17559398","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=BLVRB","resource":"BLVRB","type":"HGNC_SYMBOL"}]},{"name":"GDH/6PGL endoplasmic bifunctional protein","references":[{"annotatorClassName":"","article":{"title":"Electrochemical regeneration of NADH using conductive vanadia-silica xerogels.","authors":["Siu E"," Won K"," Park CB."],"journal":"Biotechnology progress","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17269701","id":"17269701","citationCount":10,"stringAuthors":"Siu E,  Won K,  Park CB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17269701","resource":"17269701","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Co-expression of P450 BM3 and glucose dehydrogenase by recombinant Escherichia coli and its application in an NADPH-dependent indigo production system.","authors":["Lu Y"," Mei L."],"journal":"Journal of industrial microbiology & biotechnology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17171348","id":"17171348","citationCount":10,"stringAuthors":"Lu Y,  Mei L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17171348","resource":"17171348","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"In vitro RNA editing in plant mitochondria does not require added energy.","authors":["Takenaka M"," Verbitskiy D"," van der Merwe JA"," Zehrmann A"," Plessmann U"," Urlaub H"," Brennicke A."],"journal":"FEBS letters","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17531229","id":"17531229","citationCount":3,"stringAuthors":"Takenaka M,  Verbitskiy D,  van der Merwe JA,  Zehrmann A,  Plessmann U,  Urlaub H,  Brennicke A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17531229","resource":"17531229","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"[Lymphocyte metabolism in patients with acute pancreatitis with different genotypes of GSTM1 and GSTT1 genes].","authors":["Markova EV"," Zotova NV"," Savchenko AA"," Titova NM"," Slepov EV"," Cherdantsev DV"," Konovalenko AN."],"journal":"Biomeditsinskaia khimiia","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","id":"16898590","citationCount":1,"stringAuthors":"Markova EV,  Zotova NV,  Savchenko AA,  Titova NM,  Slepov EV,  Cherdantsev DV,  Konovalenko AN."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","resource":"16898590","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Coimmobilization of dehydrogenases and their cofactors in electrochemical biosensors.","authors":["Zhang M"," Mullens C"," Gorski W."],"journal":"Analytical chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17298031","id":"17298031","citationCount":18,"stringAuthors":"Zhang M,  Mullens C,  Gorski W."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17298031","resource":"17298031","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=H6PD","resource":"H6PD","type":"HGNC_SYMBOL"}]},{"name":"GDP-L-fucose synthase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=TSTA3","resource":"TSTA3","type":"HGNC_SYMBOL"}]},{"name":"Glutamate dehydrogenase 1, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GLUD1","resource":"GLUD1","type":"HGNC_SYMBOL"}]},{"name":"Glutamate dehydrogenase 2, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GLUD2","resource":"GLUD2","type":"HGNC_SYMBOL"}]},{"name":"Glutathione reductase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Evidence for an additional disulfide reduction pathway in Escherichia coli.","authors":["Knapp KG"," Swartz JR."],"journal":"Journal of bioscience and bioengineering","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17502280","id":"17502280","citationCount":3,"stringAuthors":"Knapp KG,  Swartz JR."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17502280","resource":"17502280","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status.","authors":["Aon MA"," Cortassa S"," Maack C"," O'Rourke B."],"journal":"The Journal of biological chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17540766","id":"17540766","citationCount":92,"stringAuthors":"Aon MA,  Cortassa S,  Maack C,  O'Rourke B."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17540766","resource":"17540766","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Damage of oxidative stress on mitochondria during microspores development in Honglian CMS line of rice.","authors":["Wan C"," Li S"," Wen L"," Kong J"," Wang K"," Zhu Y."],"journal":"Plant cell reports","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17053903","id":"17053903","citationCount":22,"stringAuthors":"Wan C,  Li S,  Wen L,  Kong J,  Wang K,  Zhu Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17053903","resource":"17053903","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The relationship of the redox potentials of thioredoxin and thioredoxin reductase from Drosophila melanogaster to the enzymatic mechanism: reduced thioredoxin is the reductant of glutathione in Drosophila.","authors":["Cheng Z"," Arscott LD"," Ballou DP"," Williams CH."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17550271","id":"17550271","citationCount":27,"stringAuthors":"Cheng Z,  Arscott LD,  Ballou DP,  Williams CH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17550271","resource":"17550271","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Zinc irreversibly damages major enzymes of energy production and antioxidant defense prior to mitochondrial permeability transition.","authors":["Gazaryan IG"," Krasinskaya IP"," Kristal BS"," Brown AM."],"journal":"The Journal of biological chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17565998","id":"17565998","citationCount":59,"stringAuthors":"Gazaryan IG,  Krasinskaya IP,  Kristal BS,  Brown AM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17565998","resource":"17565998","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GSR","resource":"GSR","type":"HGNC_SYMBOL"}]},{"name":"Glyceraldehyde-3-phosphate dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"[Lymphocyte metabolism in patients with acute pancreatitis with different genotypes of GSTM1 and GSTT1 genes].","authors":["Markova EV"," Zotova NV"," Savchenko AA"," Titova NM"," Slepov EV"," Cherdantsev DV"," Konovalenko AN."],"journal":"Biomeditsinskaia khimiia","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","id":"16898590","citationCount":1,"stringAuthors":"Markova EV,  Zotova NV,  Savchenko AA,  Titova NM,  Slepov EV,  Cherdantsev DV,  Konovalenko AN."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","resource":"16898590","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Pyridine nucleotide redox abnormalities in diabetes.","authors":["Ido Y."],"journal":"Antioxidants & redox signaling","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","id":"17508915","citationCount":36,"stringAuthors":"Ido Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","resource":"17508915","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Thioredoxin-dependent regulation of photosynthetic glyceraldehyde-3-phosphate dehydrogenase: autonomous vs. CP12-dependent mechanisms.","authors":["Trost P"," Fermani S"," Marri L"," Zaffagnini M"," Falini G"," Scagliarini S"," Pupillo P"," Sparla F."],"journal":"Photosynthesis research","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17031544","id":"17031544","citationCount":28,"stringAuthors":"Trost P,  Fermani S,  Marri L,  Zaffagnini M,  Falini G,  Scagliarini S,  Pupillo P,  Sparla F."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17031544","resource":"17031544","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Sevoflurane modulates the activity of glyceraldehyde 3-phosphate dehydrogenase.","authors":["Swearengin TA"," Fibuch EE"," Seidler NW."],"journal":"Journal of enzyme inhibition and medicinal chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17194030","id":"17194030","citationCount":3,"stringAuthors":"Swearengin TA,  Fibuch EE,  Seidler NW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17194030","resource":"17194030","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GAPDH","resource":"GAPDH","type":"HGNC_SYMBOL"}]},{"name":"Glyceraldehyde-3-phosphate dehydrogenase, testis-specific","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Oral streptococcal glyceraldehyde-3-phosphate dehydrogenase mediates interaction with Porphyromonas gingivalis fimbriae.","authors":["Maeda K"," Nagata H"," Nonaka A"," Kataoka K"," Tanaka M"," Shizukuishi S."],"journal":"Microbes and infection","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15488735","id":"15488735","citationCount":20,"stringAuthors":"Maeda K,  Nagata H,  Nonaka A,  Kataoka K,  Tanaka M,  Shizukuishi S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15488735","resource":"15488735","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Characterization of native and recombinant A4 glyceraldehyde 3-phosphate dehydrogenase. Kinetic evidence for confromation changes upon association with the small protein CP12.","authors":["Graciet E"," Lebreton S"," Camadro JM"," Gontero B."],"journal":"European journal of biochemistry","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12492483","id":"12492483","citationCount":26,"stringAuthors":"Graciet E,  Lebreton S,  Camadro JM,  Gontero B."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12492483","resource":"12492483","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase.","authors":["Ismail SA"," Park HW."],"journal":"Acta crystallographica. Section D, Biological crystallography","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16239728","id":"16239728","citationCount":16,"stringAuthors":"Ismail SA,  Park HW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16239728","resource":"16239728","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GAPDHS","resource":"GAPDHS","type":"HGNC_SYMBOL"}]},{"name":"Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic","references":[{"annotatorClassName":"","article":{"title":"New competitive inhibitors of cytosolic (NADH-dependent) rabbit muscle glycerophosphate dehydrogenase.","authors":["Fonvielle M"," Therisod H"," Hemery M"," Therisod M."],"journal":"Bioorganic & medicinal chemistry letters","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17088060","id":"17088060","citationCount":0,"stringAuthors":"Fonvielle M,  Therisod H,  Hemery M,  Therisod M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17088060","resource":"17088060","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GPD1","resource":"GPD1","type":"HGNC_SYMBOL"}]},{"name":"Heme oxygenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Oxidative stress-related factors in Bartter's and Gitelman's syndromes: relevance for angiotensin II signalling.","authors":["Calò LA"," Pagnin E"," Davis PA"," Sartori M"," Semplicini A."],"journal":"Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12897089","id":"12897089","citationCount":26,"stringAuthors":"Calò LA,  Pagnin E,  Davis PA,  Sartori M,  Semplicini A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12897089","resource":"12897089","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae.","authors":["Auclair K"," Huang HW"," Moënne-Loccoz P"," Ortiz de Montellano PR."],"journal":"Protein expression and purification","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12699699","id":"12699699","citationCount":3,"stringAuthors":"Auclair K,  Huang HW,  Moënne-Loccoz P,  Ortiz de Montellano PR."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12699699","resource":"12699699","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HMOX1","resource":"HMOX1","type":"HGNC_SYMBOL"}]},{"name":"Heme oxygenase 2","references":[{"annotatorClassName":"","article":{"title":"DNA cleavage by UVA irradiation of NADH with dioxygen via radical chain processes.","authors":["Tanaka M"," Ohkubo K"," Fukuzumi S."],"journal":"The journal of physical chemistry. A","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16986858","id":"16986858","citationCount":20,"stringAuthors":"Tanaka M,  Ohkubo K,  Fukuzumi S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16986858","resource":"16986858","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inactivation of copper, zinc superoxide dismutase by H2O2 : mechanism of protection.","authors":["Goldstone AB"," Liochev SI"," Fridovich I."],"journal":"Free radical biology & medicine","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17157188","id":"17157188","citationCount":7,"stringAuthors":"Goldstone AB,  Liochev SI,  Fridovich I."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17157188","resource":"17157188","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HMOX2","resource":"HMOX2","type":"HGNC_SYMBOL"}]},{"name":"Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neurons.","authors":["Norman JP"," Perry SW"," Kasischke KA"," Volsky DJ"," Gelbard HA."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17202348","id":"17202348","citationCount":27,"stringAuthors":"Norman JP,  Perry SW,  Kasischke KA,  Volsky DJ,  Gelbard HA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17202348","resource":"17202348","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HADH","resource":"HADH","type":"HGNC_SYMBOL"}]},{"name":"Inosine-5'-monophosphate dehydrogenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Spectrum and frequency of mutations in IMPDH1 associated with autosomal dominant retinitis pigmentosa and leber congenital amaurosis.","authors":["Bowne SJ"," Sullivan LS"," Mortimer SE"," Hedstrom L"," Zhu J"," Spellicy CJ"," Gire AI"," Hughbanks-Wheaton D"," Birch DG"," Lewis RA"," Heckenlively JR"," Daiger SP."],"journal":"Investigative ophthalmology & visual science","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16384941","id":"16384941","citationCount":69,"stringAuthors":"Bowne SJ,  Sullivan LS,  Mortimer SE,  Hedstrom L,  Zhu J,  Spellicy CJ,  Gire AI,  Hughbanks-Wheaton D,  Birch DG,  Lewis RA,  Heckenlively JR,  Daiger SP."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16384941","resource":"16384941","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IMPDH1","resource":"IMPDH1","type":"HGNC_SYMBOL"}]},{"name":"Inosine-5'-monophosphate dehydrogenase 2","references":[{"annotatorClassName":"","article":{"title":"A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity.","authors":["Wang J"," Zeevi A"," Webber S"," Girnita DM"," Addonizio L"," Selby R"," Hutchinson IV"," Burckart GJ."],"journal":"Pharmacogenetics and genomics","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17496727","id":"17496727","citationCount":31,"stringAuthors":"Wang J,  Zeevi A,  Webber S,  Girnita DM,  Addonizio L,  Selby R,  Hutchinson IV,  Burckart GJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17496727","resource":"17496727","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IMPDH2","resource":"IMPDH2","type":"HGNC_SYMBOL"}]},{"name":"Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diphosphopyridine nucleotide isocitric dehydrogenase from animal tissues.","authors":["PLAUT GW"," SUNG SC."],"journal":"The Journal of biological chemistry","year":1954,"link":"http://www.ncbi.nlm.nih.gov/pubmed/13152105","id":"13152105","citationCount":36,"stringAuthors":"PLAUT GW,  SUNG SC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/13152105","resource":"13152105","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diphosphopyridine nucleotide specific isocitric dehydrogenase of mammalian mitochondria. I. On the roles of pyridine nucleotide transhydrogenase and the isocitric dehydrogenases in the respiration of mitochondria of normal and neoplastic tissues.","authors":["Stein AM"," Stein JH"," Kirkman SK."],"journal":"Biochemistry","year":1967,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","id":"4292141","citationCount":17,"stringAuthors":"Stein AM,  Stein JH,  Kirkman SK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","resource":"4292141","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The stereochemistry of the nicotinamide adenine dinucleotide-specific isocitric dehydrogenase reaction.","authors":["Rose ZB."],"journal":"The Journal of biological chemistry","year":1966,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","id":"4380379","citationCount":1,"stringAuthors":"Rose ZB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","resource":"4380379","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IDH3A","resource":"IDH3A","type":"HGNC_SYMBOL"}]},{"name":"Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diphosphopyridine nucleotide specific isocitric dehydrogenase of mammalian mitochondria. I. On the roles of pyridine nucleotide transhydrogenase and the isocitric dehydrogenases in the respiration of mitochondria of normal and neoplastic tissues.","authors":["Stein AM"," Stein JH"," Kirkman SK."],"journal":"Biochemistry","year":1967,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","id":"4292141","citationCount":17,"stringAuthors":"Stein AM,  Stein JH,  Kirkman SK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","resource":"4292141","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NICOTINAMIDE ADENINE DINUCLEOTIDE-SPECIFIC ISOCITRIC DEHYDROGENASE. A POSSIBLE REGULATORY PROTEIN.","authors":["SANWAL BD"," ZINK MW"," STACHOW CS."],"journal":"The Journal of biological chemistry","year":1964,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14189899","id":"14189899","citationCount":25,"stringAuthors":"SANWAL BD,  ZINK MW,  STACHOW CS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14189899","resource":"14189899","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The stereochemistry of the nicotinamide adenine dinucleotide-specific isocitric dehydrogenase reaction.","authors":["Rose ZB."],"journal":"The Journal of biological chemistry","year":1966,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","id":"4380379","citationCount":1,"stringAuthors":"Rose ZB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","resource":"4380379","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IDH3B","resource":"IDH3B","type":"HGNC_SYMBOL"}]},{"name":"Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diphosphopyridine nucleotide specific isocitric dehydrogenase of mammalian mitochondria. I. On the roles of pyridine nucleotide transhydrogenase and the isocitric dehydrogenases in the respiration of mitochondria of normal and neoplastic tissues.","authors":["Stein AM"," Stein JH"," Kirkman SK."],"journal":"Biochemistry","year":1967,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","id":"4292141","citationCount":17,"stringAuthors":"Stein AM,  Stein JH,  Kirkman SK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","resource":"4292141","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NICOTINAMIDE ADENINE DINUCLEOTIDE-SPECIFIC ISOCITRIC DEHYDROGENASE. A POSSIBLE REGULATORY PROTEIN.","authors":["SANWAL BD"," ZINK MW"," STACHOW CS."],"journal":"The Journal of biological chemistry","year":1964,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14189899","id":"14189899","citationCount":25,"stringAuthors":"SANWAL BD,  ZINK MW,  STACHOW CS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14189899","resource":"14189899","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The stereochemistry of the nicotinamide adenine dinucleotide-specific isocitric dehydrogenase reaction.","authors":["Rose ZB."],"journal":"The Journal of biological chemistry","year":1966,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","id":"4380379","citationCount":1,"stringAuthors":"Rose ZB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","resource":"4380379","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IDH3G","resource":"IDH3G","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase A chain","references":[{"annotatorClassName":"","article":{"title":"Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1.","authors":["Semenza GL."],"journal":"The Biochemical journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17555402","id":"17555402","citationCount":217,"stringAuthors":"Semenza GL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17555402","resource":"17555402","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Histochemical and histopathological study of the gastric mucosa in the portal hypertensive gastropathy.","authors":["Drăghia AC."],"journal":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17308685","id":"17308685","citationCount":3,"stringAuthors":"Drăghia AC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17308685","resource":"17308685","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Kinetic parameters and lactate dehydrogenase isozyme activities support possible lactate utilization by neurons.","authors":["O'Brien J"," Kla KM"," Hopkins IB"," Malecki EA"," McKenna MC."],"journal":"Neurochemical research","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17006762","id":"17006762","citationCount":30,"stringAuthors":"O'Brien J,  Kla KM,  Hopkins IB,  Malecki EA,  McKenna MC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17006762","resource":"17006762","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHA","resource":"LDHA","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase A-like 6A","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHAL6A","resource":"LDHAL6A","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase A-like 6B","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHAL6B","resource":"LDHAL6B","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase B chain","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Domain closure, substrate specificity and catalysis of D-lactate dehydrogenase from Lactobacillus bulgaricus.","authors":["Razeto A"," Kochhar S"," Hottinger H"," Dauter M"," Wilson KS"," Lamzin VS."],"journal":"Journal of molecular biology","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12054772","id":"12054772","citationCount":33,"stringAuthors":"Razeto A,  Kochhar S,  Hottinger H,  Dauter M,  Wilson KS,  Lamzin VS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12054772","resource":"12054772","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A preliminary account of the properties of recombinant human Glyoxylate reductase (GRHPR), LDHA and LDHB with glyoxylate, and their potential roles in its metabolism.","authors":["Mdluli K"," Booth MP"," Brady RL"," Rumsby G."],"journal":"Biochimica et biophysica acta","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16198644","id":"16198644","citationCount":16,"stringAuthors":"Mdluli K,  Booth MP,  Brady RL,  Rumsby G."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16198644","resource":"16198644","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Lactate dehydrogenase isoenzymes of sperm cells and tests.","authors":["Clausen J."],"journal":"The Biochemical journal","year":1969,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4303363","id":"4303363","citationCount":11,"stringAuthors":"Clausen J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4303363","resource":"4303363","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHB","resource":"LDHB","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase C chain","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Rapid purification of lactate dehydrogenase X from mouse testes by two steps of affinity chromatography on oxamate-sepharose.","authors":["Spielmann H"," Eibs HG"," Mentzel C."],"journal":"Experientia","year":1976,"link":"http://www.ncbi.nlm.nih.gov/pubmed/182529","id":"182529","citationCount":1,"stringAuthors":"Spielmann H,  Eibs HG,  Mentzel C."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/182529","resource":"182529","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of testicular LDH-X from laboratory animals and man by gossypol and its isomers.","authors":["Morris ID"," Higgins C"," Matlin SA."],"journal":"Journal of reproduction and fertility","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3735252","id":"3735252","citationCount":3,"stringAuthors":"Morris ID,  Higgins C,  Matlin SA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3735252","resource":"3735252","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Developmental changes in lactate dehydrogenase-X activity in young jaundiced male rats.","authors":["Gu Y"," Davis DR"," Lin YC."],"journal":"Archives of andrology","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2751392","id":"2751392","citationCount":10,"stringAuthors":"Gu Y,  Davis DR,  Lin YC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2751392","resource":"2751392","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHC","resource":"LDHC","type":"HGNC_SYMBOL"}]},{"name":"Malate dehydrogenase, cytoplasmic","references":[{"annotatorClassName":"","article":{"title":"Heterologous expression of cDNAs encoding monodehydroascorbate reductases from the moss, Physcomitrella patens and characterization of the expressed enzymes.","authors":["Drew DP"," Lunde C"," Lahnstein J"," Fincher GB."],"journal":"Planta","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16983536","id":"16983536","citationCount":7,"stringAuthors":"Drew DP,  Lunde C,  Lahnstein J,  Fincher GB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16983536","resource":"16983536","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MDH1","resource":"MDH1","type":"HGNC_SYMBOL"}]},{"name":"Malate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"D-mannitol production by resting state whole cell biotrans-formation of D-fructose by heterologous mannitol and formate dehydrogenase gene expression in Bacillus megaterium.","authors":["Bäumchen C"," Roth AH"," Biedendieck R"," Malten M"," Follmann M"," Sahm H"," Bringer-Meyer S"," Jahn D."],"journal":"Biotechnology journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17619232","id":"17619232","citationCount":11,"stringAuthors":"Bäumchen C,  Roth AH,  Biedendieck R,  Malten M,  Follmann M,  Sahm H,  Bringer-Meyer S,  Jahn D."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17619232","resource":"17619232","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Fluorescent sensing layer for the determination of L-malic acid in wine.","authors":["Gallarta F"," Sáinz FJ"," Sáenz C."],"journal":"Analytical and bioanalytical chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17203264","id":"17203264","citationCount":2,"stringAuthors":"Gallarta F,  Sáinz FJ,  Sáenz C."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17203264","resource":"17203264","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"[Lymphocyte metabolism in patients with acute pancreatitis with different genotypes of GSTM1 and GSTT1 genes].","authors":["Markova EV"," Zotova NV"," Savchenko AA"," Titova NM"," Slepov EV"," Cherdantsev DV"," Konovalenko AN."],"journal":"Biomeditsinskaia khimiia","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","id":"16898590","citationCount":1,"stringAuthors":"Markova EV,  Zotova NV,  Savchenko AA,  Titova NM,  Slepov EV,  Cherdantsev DV,  Konovalenko AN."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","resource":"16898590","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Characterization of malate dehydrogenase from the hyperthermophilic archaeon Pyrobaculum islandicum.","authors":["Yennaco LJ"," Hu Y"," Holden JF."],"journal":"Extremophiles : life under extreme conditions","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17487443","id":"17487443","citationCount":5,"stringAuthors":"Yennaco LJ,  Hu Y,  Holden JF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17487443","resource":"17487443","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"L-2-hydroxyglutaric aciduria, a defect of metabolite repair.","authors":["Rzem R"," Vincent MF"," Van Schaftingen E"," Veiga-da-Cunha M."],"journal":"Journal of inherited metabolic disease","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17603759","id":"17603759","citationCount":52,"stringAuthors":"Rzem R,  Vincent MF,  Van Schaftingen E,  Veiga-da-Cunha M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17603759","resource":"17603759","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MDH2","resource":"MDH2","type":"HGNC_SYMBOL"}]},{"name":"Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The effect of ligand binding on the proteolytic pattern of methylmalonate semialdehyde dehydrogenase.","authors":["Kedishvili NY"," Popov KM"," Harris RA."],"journal":"Archives of biochemistry and biophysics","year":1991,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1898092","id":"1898092","citationCount":1,"stringAuthors":"Kedishvili NY,  Popov KM,  Harris RA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1898092","resource":"1898092","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH6A1","resource":"ALDH6A1","type":"HGNC_SYMBOL"}]},{"name":"Methylsterol monooxygenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MSMO1","resource":"MSMO1","type":"HGNC_SYMBOL"}]},{"name":"NAD(P) transhydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Expression of the Escherichia coli pntAB genes encoding a membrane-bound transhydrogenase in Corynebacterium glutamicum improves L-lysine formation.","authors":["Kabus A"," Georgi T"," Wendisch VF"," Bott M."],"journal":"Applied microbiology and biotechnology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17216441","id":"17216441","citationCount":49,"stringAuthors":"Kabus A,  Georgi T,  Wendisch VF,  Bott M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17216441","resource":"17216441","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NNT","resource":"NNT","type":"HGNC_SYMBOL"}]},{"name":"NAD-dependent malic enzyme, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ME2","resource":"ME2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The NDUFA1 gene product (MWFE protein) is essential for activity of complex I in mammalian mitochondria.","authors":["Au HC"," Seo BB"," Matsuno-Yagi A"," Yagi T"," Scheffler IE."],"journal":"Proceedings of the National Academy of Sciences of the United States of America","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10200266","id":"10200266","citationCount":28,"stringAuthors":"Au HC,  Seo BB,  Matsuno-Yagi A,  Yagi T,  Scheffler IE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10200266","resource":"10200266","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase.","authors":["Raha S"," Myint AT"," Johnstone L"," Robinson BH."],"journal":"Free radical biology & medicine","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","id":"11864782","citationCount":45,"stringAuthors":"Raha S,  Myint AT,  Johnstone L,  Robinson BH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","resource":"11864782","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA1","resource":"NDUFA1","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA10","resource":"NDUFA10","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA11","resource":"NDUFA11","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA12","resource":"NDUFA12","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA13","resource":"NDUFA13","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA2","resource":"NDUFA2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA3","resource":"NDUFA3","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA4","resource":"NDUFA4","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA4L2","resource":"NDUFA4L2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5","references":[{"annotatorClassName":"","article":{"title":"Site-specific S-glutathiolation of mitochondrial NADH ubiquinone reductase.","authors":["Chen CL"," Zhang L"," Yeh A"," Chen CA"," Green-Church KB"," Zweier JL"," Chen YR."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17444656","id":"17444656","citationCount":44,"stringAuthors":"Chen CL,  Zhang L,  Yeh A,  Chen CA,  Green-Church KB,  Zweier JL,  Chen YR."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17444656","resource":"17444656","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Role of the conserved arginine 274 and histidine 224 and 228 residues in the NuoCD subunit of complex I from Escherichia coli.","authors":["Belevich G"," Euro L"," Wikström M"," Verkhovskaya M."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17209562","id":"17209562","citationCount":15,"stringAuthors":"Belevich G,  Euro L,  Wikström M,  Verkhovskaya M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17209562","resource":"17209562","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA5","resource":"NDUFA5","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA6","resource":"NDUFA6","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA7","resource":"NDUFA7","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The nuclear-encoded human NADH:ubiquinone oxidoreductase NDUFA8 subunit: cDNA cloning, chromosomal localization, tissue distribution, and mutation detection in complex-I-deficient patients.","authors":["Triepels R"," van den Heuvel L"," Loeffen J"," Smeets R"," Trijbels F"," Smeitink J."],"journal":"Human genetics","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9860297","id":"9860297","citationCount":5,"stringAuthors":"Triepels R,  van den Heuvel L,  Loeffen J,  Smeets R,  Trijbels F,  Smeitink J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9860297","resource":"9860297","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA8","resource":"NDUFA8","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"The flavoprotein subcomplex of complex I (NADH:ubiquinone oxidoreductase) from bovine heart mitochondria: insights into the mechanisms of NADH oxidation and NAD+ reduction from protein film voltammetry.","authors":["Barker CD"," Reda T"," Hirst J."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17323923","id":"17323923","citationCount":14,"stringAuthors":"Barker CD,  Reda T,  Hirst J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17323923","resource":"17323923","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Maintenance of the metabolic homeostasis of the heart: developing a systems analysis approach.","authors":["Balaban RS."],"journal":"Annals of the New York Academy of Sciences","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17132781","id":"17132781","citationCount":15,"stringAuthors":"Balaban RS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17132781","resource":"17132781","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of complex I by Ca2+ reduces electron transport activity and the rate of superoxide anion production in cardiac submitochondrial particles.","authors":["Matsuzaki S"," Szweda LI."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17260964","id":"17260964","citationCount":11,"stringAuthors":"Matsuzaki S,  Szweda LI."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17260964","resource":"17260964","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle.","authors":["Fisher N"," Bray PG"," Ward SA"," Biagini GA."],"journal":"Trends in parasitology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17499024","id":"17499024","citationCount":32,"stringAuthors":"Fisher N,  Bray PG,  Ward SA,  Biagini GA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17499024","resource":"17499024","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cloning and sequence analysis of the gene encoding 19-kD subunit of Complex I from Dunaliella salina.","authors":["Liu Y"," Qiao DR"," Zheng HB"," Dai XL"," Bai LH"," Zeng J"," Cao Y."],"journal":"Molecular biology reports","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17530440","id":"17530440","citationCount":3,"stringAuthors":"Liu Y,  Qiao DR,  Zheng HB,  Dai XL,  Bai LH,  Zeng J,  Cao Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17530440","resource":"17530440","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA9","resource":"NDUFA9","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB1","resource":"NDUFB1","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB10","resource":"NDUFB10","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB2","resource":"NDUFB2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB3","resource":"NDUFB3","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB4","resource":"NDUFB4","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB5","resource":"NDUFB5","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB6","resource":"NDUFB6","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase.","authors":["Raha S"," Myint AT"," Johnstone L"," Robinson BH."],"journal":"Free radical biology & medicine","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","id":"11864782","citationCount":45,"stringAuthors":"Raha S,  Myint AT,  Johnstone L,  Robinson BH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","resource":"11864782","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB7","resource":"NDUFB7","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB8","resource":"NDUFB8","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB9","resource":"NDUFB9","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFC1","resource":"NDUFC1","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 subunit C2","references":[{"annotatorClassName":"","article":{"title":"Regulatory loop between redox sensing of the NADH/NAD(+) ratio by Rex (YdiH) and oxidation of NADH by NADH dehydrogenase Ndh in Bacillus subtilis.","authors":["Gyan S"," Shiohira Y"," Sato I"," Takeuchi M"," Sato T."],"journal":"Journal of bacteriology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17015645","id":"17015645","citationCount":59,"stringAuthors":"Gyan S,  Shiohira Y,  Sato I,  Takeuchi M,  Sato T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17015645","resource":"17015645","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stimulation of chlororespiration by heat and high light intensity in oat plants.","authors":["Quiles MJ."],"journal":"Plant, cell & environment","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898010","id":"16898010","citationCount":36,"stringAuthors":"Quiles MJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898010","resource":"16898010","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Generation of a membrane potential by Lactococcus lactis through aerobic electron transport.","authors":["Brooijmans RJ"," Poolman B"," Schuurman-Wolters GK"," de Vos WM"," Hugenholtz J."],"journal":"Journal of bacteriology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17496098","id":"17496098","citationCount":31,"stringAuthors":"Brooijmans RJ,  Poolman B,  Schuurman-Wolters GK,  de Vos WM,  Hugenholtz J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17496098","resource":"17496098","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Association of MT-ND5 gene variation with mitochondrial respiratory control ratio and NADH dehydrogenase activity in Tibet chicken embryos.","authors":["Bao HG"," Zhao CJ"," Li JY"," Wu Ch."],"journal":"Animal genetics","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17614984","id":"17614984","citationCount":3,"stringAuthors":"Bao HG,  Zhao CJ,  Li JY,  Wu Ch."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17614984","resource":"17614984","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Ischemic preconditioning prevents in vivo hyperoxygenation in postischemic myocardium with preservation of mitochondrial oxygen consumption.","authors":["Zhu X"," Liu B"," Zhou S"," Chen YR"," Deng Y"," Zweier JL"," He G."],"journal":"American journal of physiology. Heart and circulatory physiology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17513495","id":"17513495","citationCount":19,"stringAuthors":"Zhu X,  Liu B,  Zhou S,  Chen YR,  Deng Y,  Zweier JL,  He G."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17513495","resource":"17513495","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFC2","resource":"NDUFC2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cloning of the human mitochondrial 51 kDa subunit (NDUFV1) reveals a 100% antisense homology of its 3'UTR with the 5'UTR of the gamma-interferon inducible protein (IP-30) precursor: is this a link between mitochondrial myopathy and inflammation?","authors":["Schuelke M"," Loeffen J"," Mariman E"," Smeitink J"," van den Heuvel L."],"journal":"Biochemical and biophysical research communications","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9571201","id":"9571201","citationCount":8,"stringAuthors":"Schuelke M,  Loeffen J,  Mariman E,  Smeitink J,  van den Heuvel L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9571201","resource":"9571201","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Chromosomal localization of the human gene encoding the 51-kDa subunit of mitochondrial complex I (NDUFV1) to 11q13.","authors":["Ali ST"," Duncan AM"," Schappert K"," Heng HH"," Tsui LC"," Chow W"," Robinson BH."],"journal":"Genomics","year":1993,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8288251","id":"8288251","citationCount":13,"stringAuthors":"Ali ST,  Duncan AM,  Schappert K,  Heng HH,  Tsui LC,  Chow W,  Robinson BH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8288251","resource":"8288251","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis.","authors":["Grad LI"," Lemire BD."],"journal":"Human molecular genetics","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14662656","id":"14662656","citationCount":52,"stringAuthors":"Grad LI,  Lemire BD."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14662656","resource":"14662656","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFV1","resource":"NDUFV1","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Identification of genes regulated by UV/salicylic acid.","authors":["Paunesku T"," Chang-Liu CM"," Shearin-Jones P"," Watson C"," Milton J"," Oryhon J"," Salbego D"," Milosavljevic A"," Woloschak GE."],"journal":"International journal of radiation biology","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10716640","id":"10716640","citationCount":2,"stringAuthors":"Paunesku T,  Chang-Liu CM,  Shearin-Jones P,  Watson C,  Milton J,  Oryhon J,  Salbego D,  Milosavljevic A,  Woloschak GE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10716640","resource":"10716640","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFV2","resource":"NDUFV2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFV3","resource":"NDUFV3","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS2","resource":"NDUFS2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS3","resource":"NDUFS3","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The NADH: ubiquinone oxidoreductase (complex I) of the mammalian respiratory chain and the cAMP cascade.","authors":["Papa S"," Sardanelli AM"," Scacco S"," Petruzzella V"," Technikova-Dobrova Z"," Vergari R"," Signorile A."],"journal":"Journal of bioenergetics and biomembranes","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11860175","id":"11860175","citationCount":23,"stringAuthors":"Papa S,  Sardanelli AM,  Scacco S,  Petruzzella V,  Technikova-Dobrova Z,  Vergari R,  Signorile A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11860175","resource":"11860175","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A nonsense mutation in the NDUFS4 gene encoding the 18 kDa (AQDQ) subunit of complex I abolishes assembly and activity of the complex in a patient with Leigh-like syndrome.","authors":["Petruzzella V"," Vergari R"," Puzziferri I"," Boffoli D"," Lamantea E"," Zeviani M"," Papa S."],"journal":"Human molecular genetics","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11181577","id":"11181577","citationCount":54,"stringAuthors":"Petruzzella V,  Vergari R,  Puzziferri I,  Boffoli D,  Lamantea E,  Zeviani M,  Papa S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11181577","resource":"11181577","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase.","authors":["Raha S"," Myint AT"," Johnstone L"," Robinson BH."],"journal":"Free radical biology & medicine","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","id":"11864782","citationCount":45,"stringAuthors":"Raha S,  Myint AT,  Johnstone L,  Robinson BH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","resource":"11864782","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS4","resource":"NDUFS4","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 5","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The human NADH: ubiquinone oxidoreductase NDUFS5 (15 kDa) subunit: cDNA cloning, chromosomal localization, tissue distribution and the absence of mutations in isolated complex I-deficient patients.","authors":["Loeffen J"," Smeets R"," Smeitink J"," Triepels R"," Sengers R"," Trijbels F"," van den Heuvel L."],"journal":"Journal of inherited metabolic disease","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10070614","id":"10070614","citationCount":3,"stringAuthors":"Loeffen J,  Smeets R,  Smeitink J,  Triepels R,  Sengers R,  Trijbels F,  van den Heuvel L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10070614","resource":"10070614","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS5","resource":"NDUFS5","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS6","resource":"NDUFS6","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone.","authors":["Schuler F"," Yano T"," Di Bernardo S"," Yagi T"," Yankovskaya V"," Singer TP"," Casida JE."],"journal":"Proceedings of the National Academy of Sciences of the United States of America","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10097178","id":"10097178","citationCount":51,"stringAuthors":"Schuler F,  Yano T,  Di Bernardo S,  Yagi T,  Yankovskaya V,  Singer TP,  Casida JE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10097178","resource":"10097178","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Assignment of the PSST subunit gene of human mitochondrial complex I to chromosome 19p13.","authors":["Hyslop SJ"," Duncan AM"," Pitkänen S"," Robinson BH."],"journal":"Genomics","year":1996,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8938450","id":"8938450","citationCount":8,"stringAuthors":"Hyslop SJ,  Duncan AM,  Pitkänen S,  Robinson BH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8938450","resource":"8938450","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Intimate relationships of the large and the small subunits of all nickel hydrogenases with two nuclear-encoded subunits of mitochondrial NADH: ubiquinone oxidoreductase.","authors":["Albracht SP."],"journal":"Biochimica et biophysica acta","year":1993,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8369340","id":"8369340","citationCount":22,"stringAuthors":"Albracht SP."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8369340","resource":"8369340","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS7","resource":"NDUFS7","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Learning from hydrogenases: location of a proton pump and of a second FMN in bovine NADH--ubiquinone oxidoreductase (Complex I).","authors":["Albracht SP"," Hedderich R."],"journal":"FEBS letters","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11086155","id":"11086155","citationCount":29,"stringAuthors":"Albracht SP,  Hedderich R."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11086155","resource":"11086155","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The first nuclear-encoded complex I mutation in a patient with Leigh syndrome.","authors":["Loeffen J"," Smeitink J"," Triepels R"," Smeets R"," Schuelke M"," Sengers R"," Trijbels F"," Hamel B"," Mullaart R"," van den Heuvel L."],"journal":"American journal of human genetics","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9837812","id":"9837812","citationCount":101,"stringAuthors":"Loeffen J,  Smeitink J,  Triepels R,  Smeets R,  Schuelke M,  Sengers R,  Trijbels F,  Hamel B,  Mullaart R,  van den Heuvel L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9837812","resource":"9837812","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Association of ferredoxin-NADP oxidoreductase with the chloroplastic pyridine nucleotide dehydrogenase complex in barley leaves","authors":["Jose Quiles M"," Cuello J."],"journal":"Plant physiology","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9576793","id":"9576793","citationCount":23,"stringAuthors":"Jose Quiles M,  Cuello J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9576793","resource":"9576793","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS8","resource":"NDUFS8","type":"HGNC_SYMBOL"}]},{"name":"NADH-cytochrome b5 reductase 3","references":[{"annotatorClassName":"","article":{"title":"Expression and characterization of a functional canine variant of cytochrome b5 reductase.","authors":["Roma GW"," Crowley LJ"," Barber MJ."],"journal":"Archives of biochemistry and biophysics","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16814740","id":"16814740","citationCount":5,"stringAuthors":"Roma GW,  Crowley LJ,  Barber MJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16814740","resource":"16814740","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A novel mutation of the cytochrome-b5 reductase gene in an Indian patient: the molecular basis of type I methemoglobinemia.","authors":["Nussenzveig RH"," Lingam HB"," Gaikwad A"," Zhu Q"," Jing N"," Prchal JT."],"journal":"Haematologica","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17082011","id":"17082011","citationCount":9,"stringAuthors":"Nussenzveig RH,  Lingam HB,  Gaikwad A,  Zhu Q,  Jing N,  Prchal JT."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17082011","resource":"17082011","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Structure of Physarum polycephalum cytochrome b5 reductase at 1.56 A resolution.","authors":["Kim S"," Suga M"," Ogasahara K"," Ikegami T"," Minami Y"," Yubisui T"," Tsukihara T."],"journal":"Acta crystallographica. Section F, Structural biology and crystallization communications","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17401193","id":"17401193","citationCount":3,"stringAuthors":"Kim S,  Suga M,  Ogasahara K,  Ikegami T,  Minami Y,  Yubisui T,  Tsukihara T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17401193","resource":"17401193","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Reductive detoxification of arylhydroxylamine carcinogens by human NADH cytochrome b5 reductase and cytochrome b5.","authors":["Kurian JR"," Chin NA"," Longlais BJ"," Hayes KL"," Trepanier LA."],"journal":"Chemical research in toxicology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17040106","id":"17040106","citationCount":14,"stringAuthors":"Kurian JR,  Chin NA,  Longlais BJ,  Hayes KL,  Trepanier LA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17040106","resource":"17040106","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Structure and properties of the recombinant NADH-cytochrome b5 reductase of Physarum polycephalum.","authors":["Ikegami T"," Kameyama E"," Yamamoto SY"," Minami Y"," Yubisui T."],"journal":"Bioscience, biotechnology, and biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17341833","id":"17341833","citationCount":1,"stringAuthors":"Ikegami T,  Kameyama E,  Yamamoto SY,  Minami Y,  Yubisui T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17341833","resource":"17341833","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=CYB5R3","resource":"CYB5R3","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS1","resource":"NDUFS1","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"TTD: Therapeutic Target Database.","authors":["Chen X"," Ji ZL"," Chen YZ."],"journal":"Nucleic acids research","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","id":"11752352","citationCount":104,"stringAuthors":"Chen X,  Ji ZL,  Chen YZ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","resource":"11752352","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND1","resource":"MT-ND1","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Differences in activity of cytochrome C oxidase in brain between sleep and wakefulness.","authors":["Nikonova EV"," Vijayasarathy C"," Zhang L"," Cater JR"," Galante RJ"," Ward SE"," Avadhani NG"," Pack AI."],"journal":"Sleep","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15700717","id":"15700717","citationCount":14,"stringAuthors":"Nikonova EV,  Vijayasarathy C,  Zhang L,  Cater JR,  Galante RJ,  Ward SE,  Avadhani NG,  Pack AI."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15700717","resource":"15700717","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"[The changes of gene expression in multiple myeloma treated with thalidomide].","authors":["Zhang HB"," Chen SL"," Liu JZ"," Xiao B"," Chen ZB"," Wang HJ."],"journal":"Zhonghua nei ke za zhi","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12882707","id":"12882707","citationCount":0,"stringAuthors":"Zhang HB,  Chen SL,  Liu JZ,  Xiao B,  Chen ZB,  Wang HJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12882707","resource":"12882707","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"TTD: Therapeutic Target Database.","authors":["Chen X"," Ji ZL"," Chen YZ."],"journal":"Nucleic acids research","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","id":"11752352","citationCount":104,"stringAuthors":"Chen X,  Ji ZL,  Chen YZ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","resource":"11752352","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND2","resource":"MT-ND2","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"TTD: Therapeutic Target Database.","authors":["Chen X"," Ji ZL"," Chen YZ."],"journal":"Nucleic acids research","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","id":"11752352","citationCount":104,"stringAuthors":"Chen X,  Ji ZL,  Chen YZ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","resource":"11752352","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND3","resource":"MT-ND3","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells.","authors":["Shen XY"," Zacal N"," Singh G"," Rainbow AJ."],"journal":"Photochemistry and photobiology","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15560738","id":"15560738","citationCount":16,"stringAuthors":"Shen XY,  Zacal N,  Singh G,  Rainbow AJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15560738","resource":"15560738","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Oxidative stress induces differential gene expression in a human lens epithelial cell line.","authors":["Carper DA"," Sun JK"," Iwata T"," Zigler JS"," Ibaraki N"," Lin LR"," Reddy V."],"journal":"Investigative ophthalmology & visual science","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9950599","id":"9950599","citationCount":21,"stringAuthors":"Carper DA,  Sun JK,  Iwata T,  Zigler JS,  Ibaraki N,  Lin LR,  Reddy V."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9950599","resource":"9950599","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Deletion of the structural gene for the NADH-dehydrogenase subunit 4 of Synechocystis 6803 alters respiratory properties.","authors":["Dzelzkalns VA"," Obinger C"," Regelsberger G"," Niederhauser H"," Kamensek M"," Peschek GA"," Bogorad L."],"journal":"Plant physiology","year":1994,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7846157","id":"7846157","citationCount":7,"stringAuthors":"Dzelzkalns VA,  Obinger C,  Regelsberger G,  Niederhauser H,  Kamensek M,  Peschek GA,  Bogorad L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7846157","resource":"7846157","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND4","resource":"MT-ND4","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 4L","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND4L","resource":"MT-ND4L","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 5","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Phylogenetic reconstruction of the Felidae using 16S rRNA and NADH-5 mitochondrial genes.","authors":["Johnson WE"," O'Brien SJ."],"journal":"Journal of molecular evolution","year":1997,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9071018","id":"9071018","citationCount":41,"stringAuthors":"Johnson WE,  O'Brien SJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9071018","resource":"9071018","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Association of MT-ND5 gene variation with mitochondrial respiratory control ratio and NADH dehydrogenase activity in Tibet chicken embryos.","authors":["Bao HG"," Zhao CJ"," Li JY"," Wu Ch."],"journal":"Animal genetics","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17614984","id":"17614984","citationCount":3,"stringAuthors":"Bao HG,  Zhao CJ,  Li JY,  Wu Ch."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17614984","resource":"17614984","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND5","resource":"MT-ND5","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 6","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND6","resource":"MT-ND6","type":"HGNC_SYMBOL"}]},{"name":"NADP-dependent malic enzyme","references":[{"annotatorClassName":"","article":{"title":"Determining Actinobacillus succinogenes metabolic pathways and fluxes by NMR and GC-MS analyses of 13C-labeled metabolic product isotopomers.","authors":["McKinlay JB"," Shachar-Hill Y"," Zeikus JG"," Vieille C."],"journal":"Metabolic engineering","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17197218","id":"17197218","citationCount":52,"stringAuthors":"McKinlay JB,  Shachar-Hill Y,  Zeikus JG,  Vieille C."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17197218","resource":"17197218","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ME1","resource":"ME1","type":"HGNC_SYMBOL"}]},{"name":"NADP-dependent malic enzyme, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates.","authors":["Luo C"," Wang X"," Long J"," Liu J."],"journal":"Journal of biochemical and biophysical methods","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16740313","id":"16740313","citationCount":9,"stringAuthors":"Luo C,  Wang X,  Long J,  Liu J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16740313","resource":"16740313","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Identification of cold acclimation-responsive Rhododendron genes for lipid metabolism, membrane transport and lignin biosynthesis: importance of moderately abundant ESTs in genomic studies.","authors":["Wei H"," Dhanaraj AL"," Arora R"," Rowland LJ"," Fu Y"," Sun L."],"journal":"Plant, cell & environment","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17080607","id":"17080607","citationCount":21,"stringAuthors":"Wei H,  Dhanaraj AL,  Arora R,  Rowland LJ,  Fu Y,  Sun L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17080607","resource":"17080607","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"L-2-hydroxyglutaric aciduria, a defect of metabolite repair.","authors":["Rzem R"," Vincent MF"," Van Schaftingen E"," Veiga-da-Cunha M."],"journal":"Journal of inherited metabolic disease","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17603759","id":"17603759","citationCount":52,"stringAuthors":"Rzem R,  Vincent MF,  Van Schaftingen E,  Veiga-da-Cunha M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17603759","resource":"17603759","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ME3","resource":"ME3","type":"HGNC_SYMBOL"}]},{"name":"Peroxisomal bifunctional enzyme","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=EHHADH","resource":"EHHADH","type":"HGNC_SYMBOL"}]},{"name":"Peroxisomal multifunctional enzyme type 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Binary structure of the two-domain (3R)-hydroxyacyl-CoA dehydrogenase from rat peroxisomal multifunctional enzyme type 2 at 2.38 A resolution.","authors":["Haapalainen AM"," Koski MK"," Qin YM"," Hiltunen JK"," Glumoff T."],"journal":"Structure (London, England : 1993)","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12517343","id":"12517343","citationCount":21,"stringAuthors":"Haapalainen AM,  Koski MK,  Qin YM,  Hiltunen JK,  Glumoff T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12517343","resource":"12517343","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B4","resource":"HSD17B4","type":"HGNC_SYMBOL"}]},{"name":"Pyrroline-5-carboxylate reductase 1, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Glutamine synthetase and glutamate dehydrogenase contribute differentially to proline accumulation in leaves of wheat (Triticum aestivum) seedlings exposed to different salinity.","authors":["Wang ZQ"," Yuan YZ"," Ou JQ"," Lin QH"," Zhang CF."],"journal":"Journal of plant physiology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16777263","id":"16777263","citationCount":28,"stringAuthors":"Wang ZQ,  Yuan YZ,  Ou JQ,  Lin QH,  Zhang CF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16777263","resource":"16777263","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Plant P5C reductase as a new target for aminomethylenebisphosphonates.","authors":["Forlani G"," Giberti S"," Berlicki L"," Petrollino D"," Kafarski P."],"journal":"Journal of agricultural and food chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17474756","id":"17474756","citationCount":13,"stringAuthors":"Forlani G,  Giberti S,  Berlicki L,  Petrollino D,  Kafarski P."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17474756","resource":"17474756","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PYCR1","resource":"PYCR1","type":"HGNC_SYMBOL"}]},{"name":"Pyrroline-5-carboxylate reductase 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Purification and characterization of Delta(1)-pyrroline-5-carboxylate reductase isoenzymes, indicating differential distribution in spinach (Spinacia oleracea L.) leaves.","authors":["Murahama M"," Yoshida T"," Hayashi F"," Ichino T"," Sanada Y"," Wada K."],"journal":"Plant & cell physiology","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11479381","id":"11479381","citationCount":15,"stringAuthors":"Murahama M,  Yoshida T,  Hayashi F,  Ichino T,  Sanada Y,  Wada K."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11479381","resource":"11479381","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PYCR2","resource":"PYCR2","type":"HGNC_SYMBOL"}]},{"name":"Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PDHA1","resource":"PDHA1","type":"HGNC_SYMBOL"}]},{"name":"Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PDHA2","resource":"PDHA2","type":"HGNC_SYMBOL"}]},{"name":"Pyruvate dehydrogenase E1 component subunit beta, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Regulation of pyruvate dehydrogenase in isolated rat liver mitochondria. Effects of octanoate, oxidation-reduction state, and adenosine triphosphate to adenosine diphosphate ratio.","authors":["Taylor SI"," Mukherjee C"," Jungas RL."],"journal":"The Journal of biological chemistry","year":1975,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1116996","id":"1116996","citationCount":34,"stringAuthors":"Taylor SI,  Mukherjee C,  Jungas RL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1116996","resource":"1116996","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PDHB","resource":"PDHB","type":"HGNC_SYMBOL"}]},{"name":"Retinal dehydrogenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Activities of cytosolic aldehyde dehydrogenase isozymes in colon cancer: determination using selective, fluorimetric assays.","authors":["WroczyÅ„ski P"," Nowak M"," Wierzchowski J"," Szubert A"," PolaÅ„ski J."],"journal":"Acta poloniae pharmaceutica","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16583981","id":"16583981","citationCount":3,"stringAuthors":"WroczyÅ„ski P,  Nowak M,  Wierzchowski J,  Szubert A,  PolaÅ„ski J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16583981","resource":"16583981","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal.","authors":["Russo J"," Barnes A"," Berger K"," Desgrosellier J"," Henderson J"," Kanters A"," Merkov L."],"journal":"BMC pharmacology","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11872149","id":"11872149","citationCount":10,"stringAuthors":"Russo J,  Barnes A,  Berger K,  Desgrosellier J,  Henderson J,  Kanters A,  Merkov L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11872149","resource":"11872149","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH1A1","resource":"ALDH1A1","type":"HGNC_SYMBOL"}]},{"name":"Retinal dehydrogenase 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The structure of retinal dehydrogenase type II at 2.7 A resolution: implications for retinal specificity.","authors":["Lamb AL"," Newcomer ME."],"journal":"Biochemistry","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10320326","id":"10320326","citationCount":51,"stringAuthors":"Lamb AL,  Newcomer ME."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10320326","resource":"10320326","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal.","authors":["Russo J"," Barnes A"," Berger K"," Desgrosellier J"," Henderson J"," Kanters A"," Merkov L."],"journal":"BMC pharmacology","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11872149","id":"11872149","citationCount":10,"stringAuthors":"Russo J,  Barnes A,  Berger K,  Desgrosellier J,  Henderson J,  Kanters A,  Merkov L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11872149","resource":"11872149","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH1A2","resource":"ALDH1A2","type":"HGNC_SYMBOL"}]},{"name":"Ribosyldihydronicotinamide dehydrogenase [quinone]","references":[{"annotatorClassName":"","article":{"title":"Reduction of mitomycin C is catalysed by human recombinant NRH:quinone oxidoreductase 2 using reduced nicotinamide adenine dinucleotide as an electron donating co-factor.","authors":["Jamieson D"," Tung AT"," Knox RJ"," Boddy AV."],"journal":"British journal of cancer","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17031400","id":"17031400","citationCount":12,"stringAuthors":"Jamieson D,  Tung AT,  Knox RJ,  Boddy AV."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17031400","resource":"17031400","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NQO1 and NQO2 regulation of humoral immunity and autoimmunity.","authors":["Iskander K"," Li J"," Han S"," Zheng B"," Jaiswal AK."],"journal":"The Journal of biological chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16905546","id":"16905546","citationCount":28,"stringAuthors":"Iskander K,  Li J,  Han S,  Zheng B,  Jaiswal AK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16905546","resource":"16905546","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NQO2","resource":"NQO2","type":"HGNC_SYMBOL"}]},{"name":"Short-chain specific acyl-CoA dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ACADS","resource":"ACADS","type":"HGNC_SYMBOL"}]},{"name":"Sorbitol dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"Pyridine nucleotide redox abnormalities in diabetes.","authors":["Ido Y."],"journal":"Antioxidants & redox signaling","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","id":"17508915","citationCount":36,"stringAuthors":"Ido Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","resource":"17508915","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase.","authors":["Klimacek M"," Hellmer H"," Nidetzky B."],"journal":"The Biochemical journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17343568","id":"17343568","citationCount":8,"stringAuthors":"Klimacek M,  Hellmer H,  Nidetzky B."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17343568","resource":"17343568","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SORD","resource":"SORD","type":"HGNC_SYMBOL"}]},{"name":"Steroid 17-alpha-hydroxylase/17,20 lyase","references":[{"annotatorClassName":"","article":{"title":"Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase.","authors":["Pandey AV"," Kempná P"," Hofer G"," Mullis PE"," Flück CE."],"journal":"Molecular endocrinology (Baltimore, Md.)","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17595315","id":"17595315","citationCount":49,"stringAuthors":"Pandey AV,  Kempná P,  Hofer G,  Mullis PE,  Flück CE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17595315","resource":"17595315","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=CYP17A1","resource":"CYP17A1","type":"HGNC_SYMBOL"}]},{"name":"Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Changes in gene expression associated with loss of function of the NSDHL sterol dehydrogenase in mouse embryonic fibroblasts.","authors":["Cunningham D"," Swartzlander D"," Liyanarachchi S"," Davuluri RV"," Herman GE."],"journal":"Journal of Lipid Research","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15805545","id":"15805545","citationCount":8,"stringAuthors":"Cunningham D,  Swartzlander D,  Liyanarachchi S,  Davuluri RV,  Herman GE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15805545","resource":"15805545","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NSDHL","resource":"NSDHL","type":"HGNC_SYMBOL"}]},{"name":"Succinate-semialdehyde dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH5A1","resource":"ALDH5A1","type":"HGNC_SYMBOL"}]},{"name":"Testosterone 17-beta-dehydrogenase 3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Relationship between steroids and pyridine nucleotides in the oxido-reduction catalyzed by the 17 beta-hydroxysteroid dehydrogenase purified from the porcine testicular microsomal fraction.","authors":["Inano H"," Tamaoki B."],"journal":"European journal of biochemistry","year":1975,"link":"http://www.ncbi.nlm.nih.gov/pubmed/237755","id":"237755","citationCount":9,"stringAuthors":"Inano H,  Tamaoki B."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/237755","resource":"237755","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B3","resource":"HSD17B3","type":"HGNC_SYMBOL"}]},{"name":"Trifunctional enzyme subunit alpha, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HADHA","resource":"HADHA","type":"HGNC_SYMBOL"}]},{"name":"Tyrosinase","references":[{"annotatorClassName":"","article":{"title":"Decolourization of azo dye methyl red by Saccharomyces cerevisiae MTCC 463.","authors":["Jadhav JP"," Parshetti GK"," Kalme SD"," Govindwar SP."],"journal":"Chemosphere","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17292452","id":"17292452","citationCount":47,"stringAuthors":"Jadhav JP,  Parshetti GK,  Kalme SD,  Govindwar SP."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17292452","resource":"17292452","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A potential role for cyclized quinones derived from dopamine, DOPA, and 3,4-dihydroxyphenylacetic acid in proteasomal inhibition.","authors":["Zafar KS"," Siegel D"," Ross D."],"journal":"Molecular pharmacology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16790533","id":"16790533","citationCount":38,"stringAuthors":"Zafar KS,  Siegel D,  Ross D."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16790533","resource":"16790533","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=TYR","resource":"TYR","type":"HGNC_SYMBOL"}]},{"name":"UDP-glucose 6-dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Regulatory mechanisms of UDP-glucuronic acid biosynthesis in cultured human skin fibroblasts.","authors":["Castellani AA"," De Luca G"," Rindi S"," Salvini R"," Tira ME."],"journal":"The Italian journal of biochemistry","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3804697","id":"3804697","citationCount":2,"stringAuthors":"Castellani AA,  De Luca G,  Rindi S,  Salvini R,  Tira ME."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3804697","resource":"3804697","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Mechanism of cadmium-decreased glucuronidation in the rat.","authors":["Alary J"," Cravedi JP"," Baradat M"," Carrera G."],"journal":"Biochemical pharmacology","year":1992,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1472079","id":"1472079","citationCount":3,"stringAuthors":"Alary J,  Cravedi JP,  Baradat M,  Carrera G."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1472079","resource":"1472079","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=UGDH","resource":"UGDH","type":"HGNC_SYMBOL"}]}]}]
\ No newline at end of file
diff --git a/frontend-js/testFiles/apiCalls/projects/sample/drugs.search/query=NADH&token=MOCK_TOKEN_ID& b/frontend-js/testFiles/apiCalls/projects/sample/drugs.search/query=NADH&token=MOCK_TOKEN_ID&
index ffd7b6e79087daa6cb53851dd5b63e9189128491..104e50f5ac62d4c565bd45cc1f1616085d1e7c76 100644
--- a/frontend-js/testFiles/apiCalls/projects/sample/drugs.search/query=NADH&token=MOCK_TOKEN_ID&
+++ b/frontend-js/testFiles/apiCalls/projects/sample/drugs.search/query=NADH&token=MOCK_TOKEN_ID&
@@ -1 +1 @@
-[{"bloodBrainBarrier":"YES","brandNames":[],"description":"NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). It forms NADP with the addition of a phosphate group to the 2' position of the adenosyl nucleotide through an ester linkage. (Dorland, 27th ed) ","id":"NADH","name":"NADH","references":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.drugbank.ca/drugs/DB00157","resource":"DB00157","type":"DRUGBANK"}],"synonyms":[],"targets":[{"name":"D-beta-hydroxybutyrate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A chemiluminescence-flow injection analysis of serum 3-hydroxybutyrate using a bioreactor consisting of 3-hydroxybutyrate dehydrogenase and NADH oxidase.","authors":["Tabata M"," Totani M."],"journal":"Analytical biochemistry","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8533882","id":"8533882","citationCount":5,"stringAuthors":"Tabata M,  Totani M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8533882","resource":"8533882","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Coenzyme binding by 3-hydroxybutyrate dehydrogenase, a lipid-requiring enzyme: lecithin acts as an allosteric modulator to enhance the affinity for coenzyme.","authors":["Rudy B"," Dubois H"," Mink R"," Trommer WE"," McIntyre JO"," Fleischer S."],"journal":"Biochemistry","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2550053","id":"2550053","citationCount":8,"stringAuthors":"Rudy B,  Dubois H,  Mink R,  Trommer WE,  McIntyre JO,  Fleischer S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2550053","resource":"2550053","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Activities of NAD-specific and NADP-specific isocitrate dehydrogenases in rat-liver mitochondria. Studies with D-threo-alpha-methylisocitrate.","authors":["Smith CM"," Plaut GW."],"journal":"European journal of biochemistry","year":1979,"link":"http://www.ncbi.nlm.nih.gov/pubmed/38961","id":"38961","citationCount":11,"stringAuthors":"Smith CM,  Plaut GW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/38961","resource":"38961","type":"PUBMED"}],"targetElements":[{"id":329170,"modelId":15781,"type":"ALIAS"}],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=BDH1","resource":"BDH1","type":"HGNC_SYMBOL"}]},{"name":"11-cis retinol dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"Analysis of the NADH-dependent retinaldehyde reductase activity of amphioxus retinol dehydrogenase enzymes enhances our understanding of the evolution of the retinol dehydrogenase family.","authors":["Dalfó D"," Marqués N"," Albalat R."],"journal":"The FEBS journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17608724","id":"17608724","citationCount":10,"stringAuthors":"Dalfó D,  Marqués N,  Albalat R."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17608724","resource":"17608724","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=RDH5","resource":"RDH5","type":"HGNC_SYMBOL"}]},{"name":"15-hydroxyprostaglandin dehydrogenase [NAD(+)]","references":[{"annotatorClassName":"","article":{"title":"Corticotropin-releasing hormone receptor type 1 and type 2 mediate differential effects on 15-hydroxy prostaglandin dehydrogenase expression in cultured human chorion trophoblasts.","authors":["Gao L"," He P"," Sha J"," Liu C"," Dai L"," Hui N"," Ni X."],"journal":"Endocrinology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17463062","id":"17463062","citationCount":10,"stringAuthors":"Gao L,  He P,  Sha J,  Liu C,  Dai L,  Hui N,  Ni X."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17463062","resource":"17463062","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HPGD","resource":"HPGD","type":"HGNC_SYMBOL"}]},{"name":"2-oxoglutarate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"The tricarboxylic acid cycle, an ancient metabolic network with a novel twist.","authors":["Mailloux RJ"," Bériault R"," Lemire J"," Singh R"," Chénier DR"," Hamel RD"," Appanna VD."],"journal":"PloS one","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17668068","id":"17668068","citationCount":101,"stringAuthors":"Mailloux RJ,  Bériault R,  Lemire J,  Singh R,  Chénier DR,  Hamel RD,  Appanna VD."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17668068","resource":"17668068","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=OGDH","resource":"OGDH","type":"HGNC_SYMBOL"}]},{"name":"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of testosterone biosynthesis by ethanol: multiple sites and mechanisms in dispersed Leydig cells.","authors":["Widenius TV"," Orava MM"," Vihko RK"," Ylikahri RH"," Eriksson CJ."],"journal":"Journal of steroid biochemistry","year":1987,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3476810","id":"3476810","citationCount":14,"stringAuthors":"Widenius TV,  Orava MM,  Vihko RK,  Ylikahri RH,  Eriksson CJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3476810","resource":"3476810","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Affinity alkylation of human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase by 2 alpha-bromoacetoxyprogesterone: evidence for separate dehydrogenase and isomerase sites on one protein.","authors":["Thomas JL"," Myers RP"," Rosik LO"," Strickler RC."],"journal":"Journal of steroid biochemistry","year":1990,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2362440","id":"2362440","citationCount":4,"stringAuthors":"Thomas JL,  Myers RP,  Rosik LO,  Strickler RC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2362440","resource":"2362440","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Testicular and adrenal 3 beta-hydroxy-5-ene-steroid dehydrogenase and 5-ene-4-ene isomerase.","authors":["Ishii-Ohba H"," Inano H"," Tamaoki B."],"journal":"Journal of steroid biochemistry","year":1987,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2961942","id":"2961942","citationCount":10,"stringAuthors":"Ishii-Ohba H,  Inano H,  Tamaoki B."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2961942","resource":"2961942","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD3B1","resource":"HSD3B1","type":"HGNC_SYMBOL"}]},{"name":"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of testosterone biosynthesis by ethanol: multiple sites and mechanisms in dispersed Leydig cells.","authors":["Widenius TV"," Orava MM"," Vihko RK"," Ylikahri RH"," Eriksson CJ."],"journal":"Journal of steroid biochemistry","year":1987,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3476810","id":"3476810","citationCount":14,"stringAuthors":"Widenius TV,  Orava MM,  Vihko RK,  Ylikahri RH,  Eriksson CJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3476810","resource":"3476810","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Studies of the human testis. VII. Conversion of pregnenolone to progesterone.","authors":["Fan DF"," Troen P."],"journal":"The Journal of clinical endocrinology and metabolism","year":1975,"link":"http://www.ncbi.nlm.nih.gov/pubmed/239964","id":"239964","citationCount":19,"stringAuthors":"Fan DF,  Troen P."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/239964","resource":"239964","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Analysis of coenzyme binding by human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase using 5'-[p-(fluorosulfonyl)benzoyl]adenosine, an affinity labeling cofactor analog.","authors":["Thomas JL"," Myers RP"," Strickler RC."],"journal":"The Journal of steroid biochemistry and molecular biology","year":1991,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1911436","id":"1911436","citationCount":3,"stringAuthors":"Thomas JL,  Myers RP,  Strickler RC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1911436","resource":"1911436","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD3B2","resource":"HSD3B2","type":"HGNC_SYMBOL"}]},{"name":"3-hydroxy-3-methylglutaryl-coenzyme A reductase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Improved posthypoxic recovery in vitro on treatment with drugs used for secondary stroke prevention.","authors":["Huber R"," Riepe MW."],"journal":"Neuropharmacology","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15755483","id":"15755483","citationCount":1,"stringAuthors":"Huber R,  Riepe MW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15755483","resource":"15755483","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii.","authors":["Hedl M"," Rodwell VW."],"journal":"Protein science : a publication of the Protein Society","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15152097","id":"15152097","citationCount":10,"stringAuthors":"Hedl M,  Rodwell VW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15152097","resource":"15152097","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"3-hydroxy-3-methylglutaryl-coenzyme A reductase in the lobster mandibular organ: regulation by the eyestalk.","authors":["Li S"," Wagner CA"," Friesen JA"," Borst DW."],"journal":"General and comparative endocrinology","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14511985","id":"14511985","citationCount":13,"stringAuthors":"Li S,  Wagner CA,  Friesen JA,  Borst DW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14511985","resource":"14511985","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HMGCR","resource":"HMGCR","type":"HGNC_SYMBOL"}]},{"name":"3-hydroxyacyl-CoA dehydrogenase type-2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B10","resource":"HSD17B10","type":"HGNC_SYMBOL"}]},{"name":"3-hydroxyisobutyrate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HIBADH","resource":"HIBADH","type":"HGNC_SYMBOL"}]},{"name":"3-keto-steroid reductase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B7","resource":"HSD17B7","type":"HGNC_SYMBOL"}]},{"name":"4-trimethylaminobutyraldehyde dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Properties of gamma-aminobutyraldehyde dehydrogenase from Escherichia coli.","authors":["Prieto MI"," Martin J"," Balaña-Fouce R"," Garrido-Pertierra A."],"journal":"Biochimie","year":1987,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3129020","id":"3129020","citationCount":5,"stringAuthors":"Prieto MI,  Martin J,  Balaña-Fouce R,  Garrido-Pertierra A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3129020","resource":"3129020","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Purification and kinetic characterization of gamma-aminobutyraldehyde dehydrogenase from rat liver.","authors":["Testore G"," Colombatto S"," Silvagno F"," Bedino S."],"journal":"The international journal of biochemistry & cell biology","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7584606","id":"7584606","citationCount":4,"stringAuthors":"Testore G,  Colombatto S,  Silvagno F,  Bedino S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7584606","resource":"7584606","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH9A1","resource":"ALDH9A1","type":"HGNC_SYMBOL"}]},{"name":"7-dehydrocholesterol reductase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DHCR7","resource":"DHCR7","type":"HGNC_SYMBOL"}]},{"name":"Acyl carrier protein, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFAB1","resource":"NDUFAB1","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase 1A","references":[{"annotatorClassName":"","article":{"title":"Synthetic lethal and biochemical analyses of NAD and NADH kinases in Saccharomyces cerevisiae establish separation of cellular functions.","authors":["Bieganowski P"," Seidle HF"," Wojcik M"," Brenner C."],"journal":"The Journal of biological chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16760478","id":"16760478","citationCount":25,"stringAuthors":"Bieganowski P,  Seidle HF,  Wojcik M,  Brenner C."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16760478","resource":"16760478","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Two highly divergent alcohol dehydrogenases of melon exhibit fruit ripening-specific expression and distinct biochemical characteristics.","authors":["Manríquez D"," El-Sharkawy I"," Flores FB"," El-Yahyaoui F"," Regad F"," Bouzayen M"," Latché A"," Pech JC."],"journal":"Plant molecular biology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16897483","id":"16897483","citationCount":34,"stringAuthors":"Manríquez D,  El-Sharkawy I,  Flores FB,  El-Yahyaoui F,  Regad F,  Bouzayen M,  Latché A,  Pech JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16897483","resource":"16897483","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH1A","resource":"ADH1A","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase 1B","references":[{"annotatorClassName":"","article":{"title":"Two highly divergent alcohol dehydrogenases of melon exhibit fruit ripening-specific expression and distinct biochemical characteristics.","authors":["Manríquez D"," El-Sharkawy I"," Flores FB"," El-Yahyaoui F"," Regad F"," Bouzayen M"," Latché A"," Pech JC."],"journal":"Plant molecular biology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16897483","id":"16897483","citationCount":34,"stringAuthors":"Manríquez D,  El-Sharkawy I,  Flores FB,  El-Yahyaoui F,  Regad F,  Bouzayen M,  Latché A,  Pech JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16897483","resource":"16897483","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH1B","resource":"ADH1B","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase 1C","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Specificity of human alcohol dehydrogenase 1C*2 (gamma2gamma2) for steroids and simulation of the uncompetitive inhibition of ethanol metabolism.","authors":["Plapp BV"," Berst KB."],"journal":"Chemico-biological interactions","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12604203","id":"12604203","citationCount":3,"stringAuthors":"Plapp BV,  Berst KB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12604203","resource":"12604203","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH1C","resource":"ADH1C","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase 4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Biochemical basis of mitochondrial acetaldehyde dismutation in Saccharomyces cerevisiae.","authors":["Thielen J"," Ciriacy M."],"journal":"Journal of bacteriology","year":1991,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1938903","id":"1938903","citationCount":3,"stringAuthors":"Thielen J,  Ciriacy M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1938903","resource":"1938903","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Mouse alcohol dehydrogenase 4: kinetic mechanism, substrate specificity and simulation of effects of ethanol on retinoid metabolism.","authors":["Plapp BV"," Mitchell JL"," Berst KB."],"journal":"Chemico-biological interactions","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11306066","id":"11306066","citationCount":4,"stringAuthors":"Plapp BV,  Mitchell JL,  Berst KB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11306066","resource":"11306066","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Ethanol-induced inhibition of testosterone biosynthesis in vitro: lack of acetaldehyde effect.","authors":["Widenius TV."],"journal":"Alcohol and alcoholism (Oxford, Oxfordshire)","year":1987,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3593480","id":"3593480","citationCount":2,"stringAuthors":"Widenius TV."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3593480","resource":"3593480","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH4","resource":"ADH4","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase class 4 mu/sigma chain","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Analysis of the NADH-dependent retinaldehyde reductase activity of amphioxus retinol dehydrogenase enzymes enhances our understanding of the evolution of the retinol dehydrogenase family.","authors":["Dalfó D"," Marqués N"," Albalat R."],"journal":"The FEBS journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17608724","id":"17608724","citationCount":10,"stringAuthors":"Dalfó D,  Marqués N,  Albalat R."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17608724","resource":"17608724","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Identification and immunohistochemistry of retinol dehydrogenase from bovine retinal pigment epithelium.","authors":["Suzuki Y"," Ishiguro S"," Tamai M."],"journal":"Biochimica et biophysica acta","year":1993,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8490052","id":"8490052","citationCount":12,"stringAuthors":"Suzuki Y,  Ishiguro S,  Tamai M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8490052","resource":"8490052","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Effect of thyroid hormone on the alcohol dehydrogenase activities in rat tissues.","authors":["Kim DS"," Lee CB"," Park YS"," Ahn YH"," Kim TW"," Kee CS"," Kang JS"," Om AS."],"journal":"Journal of Korean medical science","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11410692","id":"11410692","citationCount":1,"stringAuthors":"Kim DS,  Lee CB,  Park YS,  Ahn YH,  Kim TW,  Kee CS,  Kang JS,  Om AS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11410692","resource":"11410692","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH7","resource":"ADH7","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase class-3","references":[{"annotatorClassName":"","article":{"title":"High-resolution structures of formate dehydrogenase from Candida boidinii.","authors":["Schirwitz K"," Schmidt A"," Lamzin VS."],"journal":"Protein science : a publication of the Protein Society","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17525463","id":"17525463","citationCount":24,"stringAuthors":"Schirwitz K,  Schmidt A,  Lamzin VS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17525463","resource":"17525463","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"D-mannitol production by resting state whole cell biotrans-formation of D-fructose by heterologous mannitol and formate dehydrogenase gene expression in Bacillus megaterium.","authors":["Bäumchen C"," Roth AH"," Biedendieck R"," Malten M"," Follmann M"," Sahm H"," Bringer-Meyer S"," Jahn D."],"journal":"Biotechnology journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17619232","id":"17619232","citationCount":11,"stringAuthors":"Bäumchen C,  Roth AH,  Biedendieck R,  Malten M,  Follmann M,  Sahm H,  Bringer-Meyer S,  Jahn D."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17619232","resource":"17619232","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Enhanced activity of 3alpha-hydroxysteroid dehydrogenase by addition of the co-solvent 1-butyl-3-methylimidazolium (L)-lactate in aqueous phase of biphasic systems for reductive production of steroids.","authors":["Okochi M"," Nakagawa I"," Kobayashi T"," Hayashi S"," Furusaki S"," Honda H."],"journal":"Journal of biotechnology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17092593","id":"17092593","citationCount":7,"stringAuthors":"Okochi M,  Nakagawa I,  Kobayashi T,  Hayashi S,  Furusaki S,  Honda H."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17092593","resource":"17092593","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Logic gates and elementary computing by enzymes.","authors":["Baron R"," Lioubashevski O"," Katz E"," Niazov T"," Willner I."],"journal":"The journal of physical chemistry. A","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16821840","id":"16821840","citationCount":36,"stringAuthors":"Baron R,  Lioubashevski O,  Katz E,  Niazov T,  Willner I."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16821840","resource":"16821840","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH5","resource":"ADH5","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase X, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH1B1","resource":"ALDH1B1","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase family 1 member A3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Characterization of retinaldehyde dehydrogenase 3.","authors":["Graham CE"," Brocklehurst K"," Pickersgill RW"," Warren MJ."],"journal":"The Biochemical journal","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16241904","id":"16241904","citationCount":17,"stringAuthors":"Graham CE,  Brocklehurst K,  Pickersgill RW,  Warren MJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16241904","resource":"16241904","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH1A3","resource":"ALDH1A3","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase family 3 member B1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH3B1","resource":"ALDH3B1","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase family 3 member B2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH3B2","resource":"ALDH3B2","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase, dimeric NADP-preferring","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Activities of cytosolic aldehyde dehydrogenase isozymes in colon cancer: determination using selective, fluorimetric assays.","authors":["WroczyÅ„ski P"," Nowak M"," Wierzchowski J"," Szubert A"," PolaÅ„ski J."],"journal":"Acta poloniae pharmaceutica","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16583981","id":"16583981","citationCount":3,"stringAuthors":"WroczyÅ„ski P,  Nowak M,  Wierzchowski J,  Szubert A,  PolaÅ„ski J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16583981","resource":"16583981","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH3A1","resource":"ALDH3A1","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective.","authors":["Quintanilla ME"," Tampier L"," Sapag A"," Gerdtzen Z"," Israel Y."],"journal":"American journal of physiology. Endocrinology and metabolism","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17488809","id":"17488809","citationCount":17,"stringAuthors":"Quintanilla ME,  Tampier L,  Sapag A,  Gerdtzen Z,  Israel Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17488809","resource":"17488809","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake.","authors":["Quintanilla ME"," Israel Y"," Sapag A"," Tampier L."],"journal":"Addiction biology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16961761","id":"16961761","citationCount":56,"stringAuthors":"Quintanilla ME,  Israel Y,  Sapag A,  Tampier L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16961761","resource":"16961761","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH2","resource":"ALDH2","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"Journal of steroid biochemistry","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","id":"2615366","citationCount":0,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","resource":"2615366","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Microsomal 20 alpha-hydroxysteroid dehydrogenase activity for progesterone in human placenta.","authors":["Fukuda T"," Hirato K"," Yanaihara T"," Nakayama T."],"journal":"Endocrinologia japonica","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","id":"3463506","citationCount":2,"stringAuthors":"Fukuda T,  Hirato K,  Yanaihara T,  Nakayama T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","resource":"3463506","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene.","authors":["Burczynski ME"," Sridhar GR"," Palackal NT"," Penning TM."],"journal":"The Journal of biological chemistry","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11060293","id":"11060293","citationCount":72,"stringAuthors":"Burczynski ME,  Sridhar GR,  Palackal NT,  Penning TM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11060293","resource":"11060293","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C1","resource":"AKR1C1","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells.","authors":["Rizner TL"," Lin HK"," Peehl DM"," Steckelbroeck S"," Bauman DR"," Penning TM."],"journal":"Endocrinology","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12810547","id":"12810547","citationCount":65,"stringAuthors":"Rizner TL,  Lin HK,  Peehl DM,  Steckelbroeck S,  Bauman DR,  Penning TM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12810547","resource":"12810547","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Kinetics of allopregnanolone formation catalyzed by human 3 alpha-hydroxysteroid dehydrogenase type III (AKR1C2).","authors":["Trauger JW"," Jiang A"," Stearns BA"," LoGrasso PV."],"journal":"Biochemistry","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12416991","id":"12416991","citationCount":40,"stringAuthors":"Trauger JW,  Jiang A,  Stearns BA,  LoGrasso PV."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12416991","resource":"12416991","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C2","resource":"AKR1C2","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"Journal of steroid biochemistry","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","id":"2615366","citationCount":0,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","resource":"2615366","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer between progesterone and cofactor by human placental estradiol-17 beta dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"The Journal of steroid biochemistry and molecular biology","year":1990,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2146972","id":"2146972","citationCount":0,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2146972","resource":"2146972","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Bioluminescent assay of femtomole levels of estrone and estradiol.","authors":["Nicolas JC"," Boussioux AM"," Boularan AM"," Descomps B"," Crastes de Paulet A."],"journal":"Analytical biochemistry","year":1983,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6584048","id":"6584048","citationCount":5,"stringAuthors":"Nicolas JC,  Boussioux AM,  Boularan AM,  Descomps B,  Crastes de Paulet A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6584048","resource":"6584048","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C3","resource":"AKR1C3","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Purification and characterization of oxidoreductases-catalyzing carbonyl reduction of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human liver cytosol.","authors":["Atalla A"," Breyer-Pfaff U"," Maser E."],"journal":"Xenobiotica; the fate of foreign compounds in biological systems","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11037109","id":"11037109","citationCount":29,"stringAuthors":"Atalla A,  Breyer-Pfaff U,  Maser E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11037109","resource":"11037109","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C4","resource":"AKR1C4","type":"HGNC_SYMBOL"}]},{"name":"Aldose reductase","references":[{"annotatorClassName":"","article":{"title":"Pyridine nucleotide redox abnormalities in diabetes.","authors":["Ido Y."],"journal":"Antioxidants & redox signaling","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","id":"17508915","citationCount":36,"stringAuthors":"Ido Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","resource":"17508915","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Vitamin C. Biosynthesis, recycling and degradation in mammals.","authors":["Linster CL"," Van Schaftingen E."],"journal":"The FEBS journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17222174","id":"17222174","citationCount":175,"stringAuthors":"Linster CL,  Van Schaftingen E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17222174","resource":"17222174","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1B1","resource":"AKR1B1","type":"HGNC_SYMBOL"}]},{"name":"Alpha-aminoadipic semialdehyde dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes.","authors":["de La Fuente JL"," Rumbero A"," Martín JF"," Liras P."],"journal":"The Biochemical journal","year":1997,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9355735","id":"9355735","citationCount":10,"stringAuthors":"de La Fuente JL,  Rumbero A,  Martín JF,  Liras P."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9355735","resource":"9355735","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH7A1","resource":"ALDH7A1","type":"HGNC_SYMBOL"}]},{"name":"Alpha-aminoadipic semialdehyde synthase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Determinants of substrate specificity for saccharopine dehydrogenase from Saccharomyces cerevisiae.","authors":["Xu H"," West AH"," Cook PF."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17542618","id":"17542618","citationCount":3,"stringAuthors":"Xu H,  West AH,  Cook PF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17542618","resource":"17542618","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Overall kinetic mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae.","authors":["Xu H"," West AH"," Cook PF."],"journal":"Biochemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17002315","id":"17002315","citationCount":12,"stringAuthors":"Xu H,  West AH,  Cook PF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17002315","resource":"17002315","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A proposed proton shuttle mechanism for saccharopine dehydrogenase from Saccharomyces cerevisiae.","authors":["Xu H"," Alguindigue SS"," West AH"," Cook PF."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17223709","id":"17223709","citationCount":9,"stringAuthors":"Xu H,  Alguindigue SS,  West AH,  Cook PF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17223709","resource":"17223709","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AASS","resource":"AASS","type":"HGNC_SYMBOL"}]},{"name":"Aminomethyltransferase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AMT","resource":"AMT","type":"HGNC_SYMBOL"}]},{"name":"Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MTHFD2","resource":"MTHFD2","type":"HGNC_SYMBOL"}]},{"name":"Biliverdin reductase A","references":[{"annotatorClassName":"","article":{"title":"Activation of biliverdin-IXalpha reductase by inorganic phosphate and related anions.","authors":["Franklin E"," Browne S"," Hayes J"," Boland C"," Dunne A"," Elliot G"," Mantle TJ."],"journal":"The Biochemical journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17402939","id":"17402939","citationCount":4,"stringAuthors":"Franklin E,  Browne S,  Hayes J,  Boland C,  Dunne A,  Elliot G,  Mantle TJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17402939","resource":"17402939","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=BLVRA","resource":"BLVRA","type":"HGNC_SYMBOL"}]},{"name":"C-1-tetrahydrofolate synthase, cytoplasmic","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MTHFD1","resource":"MTHFD1","type":"HGNC_SYMBOL"}]},{"name":"Corticosteroid 11-beta-dehydrogenase isozyme 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Metabolism of dexamethasone in the human kidney: nicotinamide adenine dinucleotide-dependent 11beta-reduction.","authors":["Diederich S"," Hanke B"," Oelkers W"," Bähr V."],"journal":"The Journal of Clinical Endocrinology and Metabolism","year":1997,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9141556","id":"9141556","citationCount":15,"stringAuthors":"Diederich S,  Hanke B,  Oelkers W,  Bähr V."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9141556","resource":"9141556","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Comparison of 11 beta-hydroxysteroid dehydrogenase in spontaneously hypertensive and Wistar-Kyoto rats.","authors":["Hermans JJ"," Steckel B"," Thijssen HH"," Janssen BJ"," Netter KJ"," Maser E."],"journal":"Steroids","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8585102","id":"8585102","citationCount":3,"stringAuthors":"Hermans JJ,  Steckel B,  Thijssen HH,  Janssen BJ,  Netter KJ,  Maser E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8585102","resource":"8585102","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD11B1","resource":"HSD11B1","type":"HGNC_SYMBOL"}]},{"name":"Corticosteroid 11-beta-dehydrogenase isozyme 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Localization of an 11 beta hydroxysteroid dehydrogenase activity to the distal nephron. Evidence for the existence of two species of dehydrogenase in the rat kidney.","authors":["Mercer WR"," Krozowski ZS."],"journal":"Endocrinology","year":1992,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1727721","id":"1727721","citationCount":62,"stringAuthors":"Mercer WR,  Krozowski ZS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1727721","resource":"1727721","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Comparison of 11 beta-hydroxysteroid dehydrogenase in spontaneously hypertensive and Wistar-Kyoto rats.","authors":["Hermans JJ"," Steckel B"," Thijssen HH"," Janssen BJ"," Netter KJ"," Maser E."],"journal":"Steroids","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8585102","id":"8585102","citationCount":3,"stringAuthors":"Hermans JJ,  Steckel B,  Thijssen HH,  Janssen BJ,  Netter KJ,  Maser E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8585102","resource":"8585102","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD11B2","resource":"HSD11B2","type":"HGNC_SYMBOL"}]},{"name":"Cysteine dioxygenase type 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=CDO1","resource":"CDO1","type":"HGNC_SYMBOL"}]},{"name":"Cytochrome P450 4A11","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cytochrome P450 4A, peroxisomal enzymes and nicotinamide cofactors in koala liver.","authors":["Ngo S"," Kong S"," Kirlich A"," McKinnon RA"," Stupans I."],"journal":"Comparative biochemistry and physiology. Toxicology & pharmacology : CBP","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11246504","id":"11246504","citationCount":6,"stringAuthors":"Ngo S,  Kong S,  Kirlich A,  McKinnon RA,  Stupans I."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11246504","resource":"11246504","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=CYP4A11","resource":"CYP4A11","type":"HGNC_SYMBOL"}]},{"name":"D-3-phosphoglycerate dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A new family of 2-hydroxyacid dehydrogenases.","authors":["Grant GA."],"journal":"Biochemical and biophysical research communications","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2692566","id":"2692566","citationCount":37,"stringAuthors":"Grant GA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2692566","resource":"2692566","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Serine biosynthesis in human hair follicles by the phosphorylated pathway: follicular 3-phosphoglycerate dehydrogenase.","authors":["Goldsmith LA"," O'Barr T."],"journal":"The Journal of investigative dermatology","year":1976,"link":"http://www.ncbi.nlm.nih.gov/pubmed/945314","id":"945314","citationCount":4,"stringAuthors":"Goldsmith LA,  O'Barr T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/945314","resource":"945314","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cofactor binding to Escherichia coli D-3-phosphoglycerate dehydrogenase induces multiple conformations which alter effector binding.","authors":["Grant GA"," Hu Z"," Xu XL."],"journal":"The Journal of biological chemistry","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12183470","id":"12183470","citationCount":9,"stringAuthors":"Grant GA,  Hu Z,  Xu XL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12183470","resource":"12183470","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PHGDH","resource":"PHGDH","type":"HGNC_SYMBOL"}]},{"name":"Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Crystal structure of Thermus thermophilus Delta1-pyrroline-5-carboxylate dehydrogenase.","authors":["Inagaki E"," Ohshima N"," Takahashi H"," Kuroishi C"," Yokoyama S"," Tahirov TH."],"journal":"Journal of molecular biology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16934832","id":"16934832","citationCount":35,"stringAuthors":"Inagaki E,  Ohshima N,  Takahashi H,  Kuroishi C,  Yokoyama S,  Tahirov TH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16934832","resource":"16934832","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH4A1","resource":"ALDH4A1","type":"HGNC_SYMBOL"}]},{"name":"Dihydrofolate reductase","references":[{"annotatorClassName":"","article":{"title":"Proteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis.","authors":["Argyrou A"," Jin L"," Siconilfi-Baez L"," Angeletti RH"," Blanchard JS."],"journal":"Biochemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17115689","id":"17115689","citationCount":38,"stringAuthors":"Argyrou A,  Jin L,  Siconilfi-Baez L,  Angeletti RH,  Blanchard JS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17115689","resource":"17115689","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence.","authors":["Vickers TJ"," Orsomando G"," de la Garza RD"," Scott DA"," Kang SO"," Hanson AD"," Beverley SM."],"journal":"The Journal of biological chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17032644","id":"17032644","citationCount":13,"stringAuthors":"Vickers TJ,  Orsomando G,  de la Garza RD,  Scott DA,  Kang SO,  Hanson AD,  Beverley SM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17032644","resource":"17032644","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DHFR","resource":"DHFR","type":"HGNC_SYMBOL"}]},{"name":"Dihydrolipoyl dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Histochemical staining and quantification of dihydrolipoamide dehydrogenase diaphorase activity using blue native PAGE.","authors":["Yan LJ"," Yang SH"," Shu H"," Prokai L"," Forster MJ."],"journal":"Electrophoresis","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17315258","id":"17315258","citationCount":25,"stringAuthors":"Yan LJ,  Yang SH,  Shu H,  Prokai L,  Forster MJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17315258","resource":"17315258","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Trypanosoma cruzi dihydrolipoamide dehydrogenase as target for phenothiazine cationic radicals. Effect of antioxidants.","authors":["Gutiérrez-Correa J."],"journal":"Current drug targets","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17017892","id":"17017892","citationCount":3,"stringAuthors":"Gutiérrez-Correa J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17017892","resource":"17017892","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A novel branched-chain amino acid metabolon. Protein-protein interactions in a supramolecular complex.","authors":["Islam MM"," Wallin R"," Wynn RM"," Conway M"," Fujii H"," Mobley JA"," Chuang DT"," Hutson SM."],"journal":"The Journal of biological chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17314104","id":"17314104","citationCount":32,"stringAuthors":"Islam MM,  Wallin R,  Wynn RM,  Conway M,  Fujii H,  Mobley JA,  Chuang DT,  Hutson SM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17314104","resource":"17314104","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DLD","resource":"DLD","type":"HGNC_SYMBOL"}]},{"name":"Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis.","authors":["Shi S"," Ehrt S."],"journal":"Infection and immunity","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16368957","id":"16368957","citationCount":40,"stringAuthors":"Shi S,  Ehrt S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16368957","resource":"16368957","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DLAT","resource":"DLAT","type":"HGNC_SYMBOL"}]},{"name":"Dihydropteridine reductase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Determination of NADPH-specific dihydropteridine reductase in extract from human, monkey, and bovine livers by single radial immunodiffusion: selective assay differentiating NADPH- and NADH-specific enzymes.","authors":["Nakanishi N"," Ozawa K"," Yamada S."],"journal":"Journal of biochemistry","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3086306","id":"3086306","citationCount":1,"stringAuthors":"Nakanishi N,  Ozawa K,  Yamada S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3086306","resource":"3086306","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Spectral studies of the interaction of the substrate 'quinonoid' 6-methyl dihydropterine and the coenzyme NADH used as marker in the dihydropteridine reductase assay.","authors":["van der Heiden C"," Brink W."],"journal":"Journal of inherited metabolic disease","year":1982,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6820434","id":"6820434","citationCount":0,"stringAuthors":"van der Heiden C,  Brink W."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6820434","resource":"6820434","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NADH-ferric reductase activity associated with dihydropteridine reductase.","authors":["Lee PL"," Halloran C"," Cross AR"," Beutler E."],"journal":"Biochemical and biophysical research communications","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10814540","id":"10814540","citationCount":3,"stringAuthors":"Lee PL,  Halloran C,  Cross AR,  Beutler E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10814540","resource":"10814540","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=QDPR","resource":"QDPR","type":"HGNC_SYMBOL"}]},{"name":"Estradiol 17-beta-dehydrogenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"Journal of steroid biochemistry","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","id":"2615366","citationCount":0,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","resource":"2615366","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Microsomal 20 alpha-hydroxysteroid dehydrogenase activity for progesterone in human placenta.","authors":["Fukuda T"," Hirato K"," Yanaihara T"," Nakayama T."],"journal":"Endocrinologia japonica","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","id":"3463506","citationCount":2,"stringAuthors":"Fukuda T,  Hirato K,  Yanaihara T,  Nakayama T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","resource":"3463506","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The 20 alpha-hydroxysteroid dehydrogenase of Streptomyces hydrogenans.","authors":["Rimsay RL"," Murphy GW"," Martin CJ"," Orr JC."],"journal":"European journal of biochemistry","year":1988,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3164265","id":"3164265","citationCount":1,"stringAuthors":"Rimsay RL,  Murphy GW,  Martin CJ,  Orr JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3164265","resource":"3164265","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B1","resource":"HSD17B1","type":"HGNC_SYMBOL"}]},{"name":"Estradiol 17-beta-dehydrogenase 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Microsomal 20 alpha-hydroxysteroid dehydrogenase activity for progesterone in human placenta.","authors":["Fukuda T"," Hirato K"," Yanaihara T"," Nakayama T."],"journal":"Endocrinologia japonica","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","id":"3463506","citationCount":2,"stringAuthors":"Fukuda T,  Hirato K,  Yanaihara T,  Nakayama T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","resource":"3463506","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"Journal of steroid biochemistry","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","id":"2615366","citationCount":0,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","resource":"2615366","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Prostaglandin-E2 9-reductase from corpus luteum of pseudopregnant rabbit is a member of the aldo-keto reductase superfamily featuring 20 alpha-hydroxysteroid dehydrogenase activity.","authors":["Wintergalen N"," Thole HH"," Galla HJ"," Schlegel W."],"journal":"European journal of biochemistry","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8529651","id":"8529651","citationCount":22,"stringAuthors":"Wintergalen N,  Thole HH,  Galla HJ,  Schlegel W."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8529651","resource":"8529651","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B2","resource":"HSD17B2","type":"HGNC_SYMBOL"}]},{"name":"Estradiol 17-beta-dehydrogenase 8","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B8","resource":"HSD17B8","type":"HGNC_SYMBOL"}]},{"name":"Fatty aldehyde dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Mechanism of a long-chain fatty aldehyde dehydrogenase induced during the development of bioluminescence in Beneckea harveyi.","authors":["Bognar A"," Meighen E."],"journal":"Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire","year":1983,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6603890","id":"6603890","citationCount":0,"stringAuthors":"Bognar A,  Meighen E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6603890","resource":"6603890","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH3A2","resource":"ALDH3A2","type":"HGNC_SYMBOL"}]},{"name":"Flavin reductase (NADPH)","references":[{"annotatorClassName":"","article":{"title":"Characterization of two components of the 2-naphthoate monooxygenase system from Burkholderia sp. strain JT1500.","authors":["Deng D"," Li X"," Fang X"," Sun G."],"journal":"FEMS microbiology letters","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17559398","id":"17559398","citationCount":1,"stringAuthors":"Deng D,  Li X,  Fang X,  Sun G."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17559398","resource":"17559398","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=BLVRB","resource":"BLVRB","type":"HGNC_SYMBOL"}]},{"name":"GDH/6PGL endoplasmic bifunctional protein","references":[{"annotatorClassName":"","article":{"title":"Electrochemical regeneration of NADH using conductive vanadia-silica xerogels.","authors":["Siu E"," Won K"," Park CB."],"journal":"Biotechnology progress","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17269701","id":"17269701","citationCount":10,"stringAuthors":"Siu E,  Won K,  Park CB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17269701","resource":"17269701","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Co-expression of P450 BM3 and glucose dehydrogenase by recombinant Escherichia coli and its application in an NADPH-dependent indigo production system.","authors":["Lu Y"," Mei L."],"journal":"Journal of industrial microbiology & biotechnology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17171348","id":"17171348","citationCount":10,"stringAuthors":"Lu Y,  Mei L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17171348","resource":"17171348","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"In vitro RNA editing in plant mitochondria does not require added energy.","authors":["Takenaka M"," Verbitskiy D"," van der Merwe JA"," Zehrmann A"," Plessmann U"," Urlaub H"," Brennicke A."],"journal":"FEBS letters","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17531229","id":"17531229","citationCount":3,"stringAuthors":"Takenaka M,  Verbitskiy D,  van der Merwe JA,  Zehrmann A,  Plessmann U,  Urlaub H,  Brennicke A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17531229","resource":"17531229","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"[Lymphocyte metabolism in patients with acute pancreatitis with different genotypes of GSTM1 and GSTT1 genes].","authors":["Markova EV"," Zotova NV"," Savchenko AA"," Titova NM"," Slepov EV"," Cherdantsev DV"," Konovalenko AN."],"journal":"Biomeditsinskaia khimiia","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","id":"16898590","citationCount":1,"stringAuthors":"Markova EV,  Zotova NV,  Savchenko AA,  Titova NM,  Slepov EV,  Cherdantsev DV,  Konovalenko AN."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","resource":"16898590","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Coimmobilization of dehydrogenases and their cofactors in electrochemical biosensors.","authors":["Zhang M"," Mullens C"," Gorski W."],"journal":"Analytical chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17298031","id":"17298031","citationCount":18,"stringAuthors":"Zhang M,  Mullens C,  Gorski W."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17298031","resource":"17298031","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=H6PD","resource":"H6PD","type":"HGNC_SYMBOL"}]},{"name":"GDP-L-fucose synthase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=TSTA3","resource":"TSTA3","type":"HGNC_SYMBOL"}]},{"name":"Glutamate dehydrogenase 1, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GLUD1","resource":"GLUD1","type":"HGNC_SYMBOL"}]},{"name":"Glutamate dehydrogenase 2, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GLUD2","resource":"GLUD2","type":"HGNC_SYMBOL"}]},{"name":"Glutathione reductase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Evidence for an additional disulfide reduction pathway in Escherichia coli.","authors":["Knapp KG"," Swartz JR."],"journal":"Journal of bioscience and bioengineering","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17502280","id":"17502280","citationCount":3,"stringAuthors":"Knapp KG,  Swartz JR."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17502280","resource":"17502280","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status.","authors":["Aon MA"," Cortassa S"," Maack C"," O'Rourke B."],"journal":"The Journal of biological chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17540766","id":"17540766","citationCount":92,"stringAuthors":"Aon MA,  Cortassa S,  Maack C,  O'Rourke B."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17540766","resource":"17540766","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Damage of oxidative stress on mitochondria during microspores development in Honglian CMS line of rice.","authors":["Wan C"," Li S"," Wen L"," Kong J"," Wang K"," Zhu Y."],"journal":"Plant cell reports","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17053903","id":"17053903","citationCount":22,"stringAuthors":"Wan C,  Li S,  Wen L,  Kong J,  Wang K,  Zhu Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17053903","resource":"17053903","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The relationship of the redox potentials of thioredoxin and thioredoxin reductase from Drosophila melanogaster to the enzymatic mechanism: reduced thioredoxin is the reductant of glutathione in Drosophila.","authors":["Cheng Z"," Arscott LD"," Ballou DP"," Williams CH."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17550271","id":"17550271","citationCount":27,"stringAuthors":"Cheng Z,  Arscott LD,  Ballou DP,  Williams CH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17550271","resource":"17550271","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Zinc irreversibly damages major enzymes of energy production and antioxidant defense prior to mitochondrial permeability transition.","authors":["Gazaryan IG"," Krasinskaya IP"," Kristal BS"," Brown AM."],"journal":"The Journal of biological chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17565998","id":"17565998","citationCount":59,"stringAuthors":"Gazaryan IG,  Krasinskaya IP,  Kristal BS,  Brown AM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17565998","resource":"17565998","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GSR","resource":"GSR","type":"HGNC_SYMBOL"}]},{"name":"Glyceraldehyde-3-phosphate dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"[Lymphocyte metabolism in patients with acute pancreatitis with different genotypes of GSTM1 and GSTT1 genes].","authors":["Markova EV"," Zotova NV"," Savchenko AA"," Titova NM"," Slepov EV"," Cherdantsev DV"," Konovalenko AN."],"journal":"Biomeditsinskaia khimiia","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","id":"16898590","citationCount":1,"stringAuthors":"Markova EV,  Zotova NV,  Savchenko AA,  Titova NM,  Slepov EV,  Cherdantsev DV,  Konovalenko AN."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","resource":"16898590","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Pyridine nucleotide redox abnormalities in diabetes.","authors":["Ido Y."],"journal":"Antioxidants & redox signaling","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","id":"17508915","citationCount":36,"stringAuthors":"Ido Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","resource":"17508915","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Thioredoxin-dependent regulation of photosynthetic glyceraldehyde-3-phosphate dehydrogenase: autonomous vs. CP12-dependent mechanisms.","authors":["Trost P"," Fermani S"," Marri L"," Zaffagnini M"," Falini G"," Scagliarini S"," Pupillo P"," Sparla F."],"journal":"Photosynthesis research","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17031544","id":"17031544","citationCount":28,"stringAuthors":"Trost P,  Fermani S,  Marri L,  Zaffagnini M,  Falini G,  Scagliarini S,  Pupillo P,  Sparla F."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17031544","resource":"17031544","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Sevoflurane modulates the activity of glyceraldehyde 3-phosphate dehydrogenase.","authors":["Swearengin TA"," Fibuch EE"," Seidler NW."],"journal":"Journal of enzyme inhibition and medicinal chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17194030","id":"17194030","citationCount":3,"stringAuthors":"Swearengin TA,  Fibuch EE,  Seidler NW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17194030","resource":"17194030","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GAPDH","resource":"GAPDH","type":"HGNC_SYMBOL"}]},{"name":"Glyceraldehyde-3-phosphate dehydrogenase, testis-specific","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Oral streptococcal glyceraldehyde-3-phosphate dehydrogenase mediates interaction with Porphyromonas gingivalis fimbriae.","authors":["Maeda K"," Nagata H"," Nonaka A"," Kataoka K"," Tanaka M"," Shizukuishi S."],"journal":"Microbes and infection","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15488735","id":"15488735","citationCount":20,"stringAuthors":"Maeda K,  Nagata H,  Nonaka A,  Kataoka K,  Tanaka M,  Shizukuishi S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15488735","resource":"15488735","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Characterization of native and recombinant A4 glyceraldehyde 3-phosphate dehydrogenase. Kinetic evidence for confromation changes upon association with the small protein CP12.","authors":["Graciet E"," Lebreton S"," Camadro JM"," Gontero B."],"journal":"European journal of biochemistry","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12492483","id":"12492483","citationCount":26,"stringAuthors":"Graciet E,  Lebreton S,  Camadro JM,  Gontero B."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12492483","resource":"12492483","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase.","authors":["Ismail SA"," Park HW."],"journal":"Acta crystallographica. Section D, Biological crystallography","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16239728","id":"16239728","citationCount":16,"stringAuthors":"Ismail SA,  Park HW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16239728","resource":"16239728","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GAPDHS","resource":"GAPDHS","type":"HGNC_SYMBOL"}]},{"name":"Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic","references":[{"annotatorClassName":"","article":{"title":"New competitive inhibitors of cytosolic (NADH-dependent) rabbit muscle glycerophosphate dehydrogenase.","authors":["Fonvielle M"," Therisod H"," Hemery M"," Therisod M."],"journal":"Bioorganic & medicinal chemistry letters","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17088060","id":"17088060","citationCount":0,"stringAuthors":"Fonvielle M,  Therisod H,  Hemery M,  Therisod M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17088060","resource":"17088060","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GPD1","resource":"GPD1","type":"HGNC_SYMBOL"}]},{"name":"Heme oxygenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Oxidative stress-related factors in Bartter's and Gitelman's syndromes: relevance for angiotensin II signalling.","authors":["Calò LA"," Pagnin E"," Davis PA"," Sartori M"," Semplicini A."],"journal":"Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12897089","id":"12897089","citationCount":26,"stringAuthors":"Calò LA,  Pagnin E,  Davis PA,  Sartori M,  Semplicini A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12897089","resource":"12897089","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae.","authors":["Auclair K"," Huang HW"," Moënne-Loccoz P"," Ortiz de Montellano PR."],"journal":"Protein expression and purification","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12699699","id":"12699699","citationCount":3,"stringAuthors":"Auclair K,  Huang HW,  Moënne-Loccoz P,  Ortiz de Montellano PR."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12699699","resource":"12699699","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HMOX1","resource":"HMOX1","type":"HGNC_SYMBOL"}]},{"name":"Heme oxygenase 2","references":[{"annotatorClassName":"","article":{"title":"DNA cleavage by UVA irradiation of NADH with dioxygen via radical chain processes.","authors":["Tanaka M"," Ohkubo K"," Fukuzumi S."],"journal":"The journal of physical chemistry. A","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16986858","id":"16986858","citationCount":20,"stringAuthors":"Tanaka M,  Ohkubo K,  Fukuzumi S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16986858","resource":"16986858","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inactivation of copper, zinc superoxide dismutase by H2O2 : mechanism of protection.","authors":["Goldstone AB"," Liochev SI"," Fridovich I."],"journal":"Free radical biology & medicine","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17157188","id":"17157188","citationCount":7,"stringAuthors":"Goldstone AB,  Liochev SI,  Fridovich I."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17157188","resource":"17157188","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HMOX2","resource":"HMOX2","type":"HGNC_SYMBOL"}]},{"name":"Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neurons.","authors":["Norman JP"," Perry SW"," Kasischke KA"," Volsky DJ"," Gelbard HA."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17202348","id":"17202348","citationCount":27,"stringAuthors":"Norman JP,  Perry SW,  Kasischke KA,  Volsky DJ,  Gelbard HA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17202348","resource":"17202348","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HADH","resource":"HADH","type":"HGNC_SYMBOL"}]},{"name":"Inosine-5'-monophosphate dehydrogenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Spectrum and frequency of mutations in IMPDH1 associated with autosomal dominant retinitis pigmentosa and leber congenital amaurosis.","authors":["Bowne SJ"," Sullivan LS"," Mortimer SE"," Hedstrom L"," Zhu J"," Spellicy CJ"," Gire AI"," Hughbanks-Wheaton D"," Birch DG"," Lewis RA"," Heckenlively JR"," Daiger SP."],"journal":"Investigative ophthalmology & visual science","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16384941","id":"16384941","citationCount":69,"stringAuthors":"Bowne SJ,  Sullivan LS,  Mortimer SE,  Hedstrom L,  Zhu J,  Spellicy CJ,  Gire AI,  Hughbanks-Wheaton D,  Birch DG,  Lewis RA,  Heckenlively JR,  Daiger SP."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16384941","resource":"16384941","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IMPDH1","resource":"IMPDH1","type":"HGNC_SYMBOL"}]},{"name":"Inosine-5'-monophosphate dehydrogenase 2","references":[{"annotatorClassName":"","article":{"title":"A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity.","authors":["Wang J"," Zeevi A"," Webber S"," Girnita DM"," Addonizio L"," Selby R"," Hutchinson IV"," Burckart GJ."],"journal":"Pharmacogenetics and genomics","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17496727","id":"17496727","citationCount":31,"stringAuthors":"Wang J,  Zeevi A,  Webber S,  Girnita DM,  Addonizio L,  Selby R,  Hutchinson IV,  Burckart GJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17496727","resource":"17496727","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IMPDH2","resource":"IMPDH2","type":"HGNC_SYMBOL"}]},{"name":"Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diphosphopyridine nucleotide isocitric dehydrogenase from animal tissues.","authors":["PLAUT GW"," SUNG SC."],"journal":"The Journal of biological chemistry","year":1954,"link":"http://www.ncbi.nlm.nih.gov/pubmed/13152105","id":"13152105","citationCount":36,"stringAuthors":"PLAUT GW,  SUNG SC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/13152105","resource":"13152105","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diphosphopyridine nucleotide specific isocitric dehydrogenase of mammalian mitochondria. I. On the roles of pyridine nucleotide transhydrogenase and the isocitric dehydrogenases in the respiration of mitochondria of normal and neoplastic tissues.","authors":["Stein AM"," Stein JH"," Kirkman SK."],"journal":"Biochemistry","year":1967,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","id":"4292141","citationCount":17,"stringAuthors":"Stein AM,  Stein JH,  Kirkman SK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","resource":"4292141","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The stereochemistry of the nicotinamide adenine dinucleotide-specific isocitric dehydrogenase reaction.","authors":["Rose ZB."],"journal":"The Journal of biological chemistry","year":1966,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","id":"4380379","citationCount":1,"stringAuthors":"Rose ZB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","resource":"4380379","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IDH3A","resource":"IDH3A","type":"HGNC_SYMBOL"}]},{"name":"Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diphosphopyridine nucleotide specific isocitric dehydrogenase of mammalian mitochondria. I. On the roles of pyridine nucleotide transhydrogenase and the isocitric dehydrogenases in the respiration of mitochondria of normal and neoplastic tissues.","authors":["Stein AM"," Stein JH"," Kirkman SK."],"journal":"Biochemistry","year":1967,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","id":"4292141","citationCount":17,"stringAuthors":"Stein AM,  Stein JH,  Kirkman SK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","resource":"4292141","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NICOTINAMIDE ADENINE DINUCLEOTIDE-SPECIFIC ISOCITRIC DEHYDROGENASE. A POSSIBLE REGULATORY PROTEIN.","authors":["SANWAL BD"," ZINK MW"," STACHOW CS."],"journal":"The Journal of biological chemistry","year":1964,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14189899","id":"14189899","citationCount":25,"stringAuthors":"SANWAL BD,  ZINK MW,  STACHOW CS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14189899","resource":"14189899","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The stereochemistry of the nicotinamide adenine dinucleotide-specific isocitric dehydrogenase reaction.","authors":["Rose ZB."],"journal":"The Journal of biological chemistry","year":1966,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","id":"4380379","citationCount":1,"stringAuthors":"Rose ZB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","resource":"4380379","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IDH3B","resource":"IDH3B","type":"HGNC_SYMBOL"}]},{"name":"Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diphosphopyridine nucleotide specific isocitric dehydrogenase of mammalian mitochondria. I. On the roles of pyridine nucleotide transhydrogenase and the isocitric dehydrogenases in the respiration of mitochondria of normal and neoplastic tissues.","authors":["Stein AM"," Stein JH"," Kirkman SK."],"journal":"Biochemistry","year":1967,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","id":"4292141","citationCount":17,"stringAuthors":"Stein AM,  Stein JH,  Kirkman SK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","resource":"4292141","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NICOTINAMIDE ADENINE DINUCLEOTIDE-SPECIFIC ISOCITRIC DEHYDROGENASE. A POSSIBLE REGULATORY PROTEIN.","authors":["SANWAL BD"," ZINK MW"," STACHOW CS."],"journal":"The Journal of biological chemistry","year":1964,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14189899","id":"14189899","citationCount":25,"stringAuthors":"SANWAL BD,  ZINK MW,  STACHOW CS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14189899","resource":"14189899","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The stereochemistry of the nicotinamide adenine dinucleotide-specific isocitric dehydrogenase reaction.","authors":["Rose ZB."],"journal":"The Journal of biological chemistry","year":1966,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","id":"4380379","citationCount":1,"stringAuthors":"Rose ZB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","resource":"4380379","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IDH3G","resource":"IDH3G","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase A chain","references":[{"annotatorClassName":"","article":{"title":"Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1.","authors":["Semenza GL."],"journal":"The Biochemical journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17555402","id":"17555402","citationCount":217,"stringAuthors":"Semenza GL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17555402","resource":"17555402","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Histochemical and histopathological study of the gastric mucosa in the portal hypertensive gastropathy.","authors":["Drăghia AC."],"journal":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17308685","id":"17308685","citationCount":3,"stringAuthors":"Drăghia AC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17308685","resource":"17308685","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Kinetic parameters and lactate dehydrogenase isozyme activities support possible lactate utilization by neurons.","authors":["O'Brien J"," Kla KM"," Hopkins IB"," Malecki EA"," McKenna MC."],"journal":"Neurochemical research","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17006762","id":"17006762","citationCount":30,"stringAuthors":"O'Brien J,  Kla KM,  Hopkins IB,  Malecki EA,  McKenna MC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17006762","resource":"17006762","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHA","resource":"LDHA","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase A-like 6A","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHAL6A","resource":"LDHAL6A","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase A-like 6B","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHAL6B","resource":"LDHAL6B","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase B chain","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Domain closure, substrate specificity and catalysis of D-lactate dehydrogenase from Lactobacillus bulgaricus.","authors":["Razeto A"," Kochhar S"," Hottinger H"," Dauter M"," Wilson KS"," Lamzin VS."],"journal":"Journal of molecular biology","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12054772","id":"12054772","citationCount":33,"stringAuthors":"Razeto A,  Kochhar S,  Hottinger H,  Dauter M,  Wilson KS,  Lamzin VS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12054772","resource":"12054772","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A preliminary account of the properties of recombinant human Glyoxylate reductase (GRHPR), LDHA and LDHB with glyoxylate, and their potential roles in its metabolism.","authors":["Mdluli K"," Booth MP"," Brady RL"," Rumsby G."],"journal":"Biochimica et biophysica acta","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16198644","id":"16198644","citationCount":16,"stringAuthors":"Mdluli K,  Booth MP,  Brady RL,  Rumsby G."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16198644","resource":"16198644","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Lactate dehydrogenase isoenzymes of sperm cells and tests.","authors":["Clausen J."],"journal":"The Biochemical journal","year":1969,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4303363","id":"4303363","citationCount":11,"stringAuthors":"Clausen J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4303363","resource":"4303363","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHB","resource":"LDHB","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase C chain","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Rapid purification of lactate dehydrogenase X from mouse testes by two steps of affinity chromatography on oxamate-sepharose.","authors":["Spielmann H"," Eibs HG"," Mentzel C."],"journal":"Experientia","year":1976,"link":"http://www.ncbi.nlm.nih.gov/pubmed/182529","id":"182529","citationCount":1,"stringAuthors":"Spielmann H,  Eibs HG,  Mentzel C."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/182529","resource":"182529","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of testicular LDH-X from laboratory animals and man by gossypol and its isomers.","authors":["Morris ID"," Higgins C"," Matlin SA."],"journal":"Journal of reproduction and fertility","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3735252","id":"3735252","citationCount":3,"stringAuthors":"Morris ID,  Higgins C,  Matlin SA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3735252","resource":"3735252","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Developmental changes in lactate dehydrogenase-X activity in young jaundiced male rats.","authors":["Gu Y"," Davis DR"," Lin YC."],"journal":"Archives of andrology","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2751392","id":"2751392","citationCount":10,"stringAuthors":"Gu Y,  Davis DR,  Lin YC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2751392","resource":"2751392","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHC","resource":"LDHC","type":"HGNC_SYMBOL"}]},{"name":"Malate dehydrogenase, cytoplasmic","references":[{"annotatorClassName":"","article":{"title":"Heterologous expression of cDNAs encoding monodehydroascorbate reductases from the moss, Physcomitrella patens and characterization of the expressed enzymes.","authors":["Drew DP"," Lunde C"," Lahnstein J"," Fincher GB."],"journal":"Planta","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16983536","id":"16983536","citationCount":7,"stringAuthors":"Drew DP,  Lunde C,  Lahnstein J,  Fincher GB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16983536","resource":"16983536","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MDH1","resource":"MDH1","type":"HGNC_SYMBOL"}]},{"name":"Malate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"D-mannitol production by resting state whole cell biotrans-formation of D-fructose by heterologous mannitol and formate dehydrogenase gene expression in Bacillus megaterium.","authors":["Bäumchen C"," Roth AH"," Biedendieck R"," Malten M"," Follmann M"," Sahm H"," Bringer-Meyer S"," Jahn D."],"journal":"Biotechnology journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17619232","id":"17619232","citationCount":11,"stringAuthors":"Bäumchen C,  Roth AH,  Biedendieck R,  Malten M,  Follmann M,  Sahm H,  Bringer-Meyer S,  Jahn D."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17619232","resource":"17619232","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Fluorescent sensing layer for the determination of L-malic acid in wine.","authors":["Gallarta F"," Sáinz FJ"," Sáenz C."],"journal":"Analytical and bioanalytical chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17203264","id":"17203264","citationCount":2,"stringAuthors":"Gallarta F,  Sáinz FJ,  Sáenz C."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17203264","resource":"17203264","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"[Lymphocyte metabolism in patients with acute pancreatitis with different genotypes of GSTM1 and GSTT1 genes].","authors":["Markova EV"," Zotova NV"," Savchenko AA"," Titova NM"," Slepov EV"," Cherdantsev DV"," Konovalenko AN."],"journal":"Biomeditsinskaia khimiia","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","id":"16898590","citationCount":1,"stringAuthors":"Markova EV,  Zotova NV,  Savchenko AA,  Titova NM,  Slepov EV,  Cherdantsev DV,  Konovalenko AN."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","resource":"16898590","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Characterization of malate dehydrogenase from the hyperthermophilic archaeon Pyrobaculum islandicum.","authors":["Yennaco LJ"," Hu Y"," Holden JF."],"journal":"Extremophiles : life under extreme conditions","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17487443","id":"17487443","citationCount":5,"stringAuthors":"Yennaco LJ,  Hu Y,  Holden JF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17487443","resource":"17487443","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"L-2-hydroxyglutaric aciduria, a defect of metabolite repair.","authors":["Rzem R"," Vincent MF"," Van Schaftingen E"," Veiga-da-Cunha M."],"journal":"Journal of inherited metabolic disease","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17603759","id":"17603759","citationCount":52,"stringAuthors":"Rzem R,  Vincent MF,  Van Schaftingen E,  Veiga-da-Cunha M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17603759","resource":"17603759","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MDH2","resource":"MDH2","type":"HGNC_SYMBOL"}]},{"name":"Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The effect of ligand binding on the proteolytic pattern of methylmalonate semialdehyde dehydrogenase.","authors":["Kedishvili NY"," Popov KM"," Harris RA."],"journal":"Archives of biochemistry and biophysics","year":1991,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1898092","id":"1898092","citationCount":1,"stringAuthors":"Kedishvili NY,  Popov KM,  Harris RA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1898092","resource":"1898092","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH6A1","resource":"ALDH6A1","type":"HGNC_SYMBOL"}]},{"name":"Methylsterol monooxygenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MSMO1","resource":"MSMO1","type":"HGNC_SYMBOL"}]},{"name":"NAD(P) transhydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Expression of the Escherichia coli pntAB genes encoding a membrane-bound transhydrogenase in Corynebacterium glutamicum improves L-lysine formation.","authors":["Kabus A"," Georgi T"," Wendisch VF"," Bott M."],"journal":"Applied microbiology and biotechnology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17216441","id":"17216441","citationCount":49,"stringAuthors":"Kabus A,  Georgi T,  Wendisch VF,  Bott M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17216441","resource":"17216441","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NNT","resource":"NNT","type":"HGNC_SYMBOL"}]},{"name":"NAD-dependent malic enzyme, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ME2","resource":"ME2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The NDUFA1 gene product (MWFE protein) is essential for activity of complex I in mammalian mitochondria.","authors":["Au HC"," Seo BB"," Matsuno-Yagi A"," Yagi T"," Scheffler IE."],"journal":"Proceedings of the National Academy of Sciences of the United States of America","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10200266","id":"10200266","citationCount":28,"stringAuthors":"Au HC,  Seo BB,  Matsuno-Yagi A,  Yagi T,  Scheffler IE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10200266","resource":"10200266","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase.","authors":["Raha S"," Myint AT"," Johnstone L"," Robinson BH."],"journal":"Free radical biology & medicine","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","id":"11864782","citationCount":45,"stringAuthors":"Raha S,  Myint AT,  Johnstone L,  Robinson BH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","resource":"11864782","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA1","resource":"NDUFA1","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA10","resource":"NDUFA10","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA11","resource":"NDUFA11","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA12","resource":"NDUFA12","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA13","resource":"NDUFA13","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA2","resource":"NDUFA2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA3","resource":"NDUFA3","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA4","resource":"NDUFA4","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA4L2","resource":"NDUFA4L2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5","references":[{"annotatorClassName":"","article":{"title":"Site-specific S-glutathiolation of mitochondrial NADH ubiquinone reductase.","authors":["Chen CL"," Zhang L"," Yeh A"," Chen CA"," Green-Church KB"," Zweier JL"," Chen YR."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17444656","id":"17444656","citationCount":42,"stringAuthors":"Chen CL,  Zhang L,  Yeh A,  Chen CA,  Green-Church KB,  Zweier JL,  Chen YR."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17444656","resource":"17444656","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Role of the conserved arginine 274 and histidine 224 and 228 residues in the NuoCD subunit of complex I from Escherichia coli.","authors":["Belevich G"," Euro L"," Wikström M"," Verkhovskaya M."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17209562","id":"17209562","citationCount":15,"stringAuthors":"Belevich G,  Euro L,  Wikström M,  Verkhovskaya M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17209562","resource":"17209562","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA5","resource":"NDUFA5","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA6","resource":"NDUFA6","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA7","resource":"NDUFA7","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The nuclear-encoded human NADH:ubiquinone oxidoreductase NDUFA8 subunit: cDNA cloning, chromosomal localization, tissue distribution, and mutation detection in complex-I-deficient patients.","authors":["Triepels R"," van den Heuvel L"," Loeffen J"," Smeets R"," Trijbels F"," Smeitink J."],"journal":"Human genetics","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9860297","id":"9860297","citationCount":5,"stringAuthors":"Triepels R,  van den Heuvel L,  Loeffen J,  Smeets R,  Trijbels F,  Smeitink J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9860297","resource":"9860297","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA8","resource":"NDUFA8","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"The flavoprotein subcomplex of complex I (NADH:ubiquinone oxidoreductase) from bovine heart mitochondria: insights into the mechanisms of NADH oxidation and NAD+ reduction from protein film voltammetry.","authors":["Barker CD"," Reda T"," Hirst J."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17323923","id":"17323923","citationCount":14,"stringAuthors":"Barker CD,  Reda T,  Hirst J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17323923","resource":"17323923","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Maintenance of the metabolic homeostasis of the heart: developing a systems analysis approach.","authors":["Balaban RS."],"journal":"Annals of the New York Academy of Sciences","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17132781","id":"17132781","citationCount":15,"stringAuthors":"Balaban RS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17132781","resource":"17132781","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of complex I by Ca2+ reduces electron transport activity and the rate of superoxide anion production in cardiac submitochondrial particles.","authors":["Matsuzaki S"," Szweda LI."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17260964","id":"17260964","citationCount":11,"stringAuthors":"Matsuzaki S,  Szweda LI."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17260964","resource":"17260964","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle.","authors":["Fisher N"," Bray PG"," Ward SA"," Biagini GA."],"journal":"Trends in parasitology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17499024","id":"17499024","citationCount":32,"stringAuthors":"Fisher N,  Bray PG,  Ward SA,  Biagini GA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17499024","resource":"17499024","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cloning and sequence analysis of the gene encoding 19-kD subunit of Complex I from Dunaliella salina.","authors":["Liu Y"," Qiao DR"," Zheng HB"," Dai XL"," Bai LH"," Zeng J"," Cao Y."],"journal":"Molecular biology reports","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17530440","id":"17530440","citationCount":3,"stringAuthors":"Liu Y,  Qiao DR,  Zheng HB,  Dai XL,  Bai LH,  Zeng J,  Cao Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17530440","resource":"17530440","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA9","resource":"NDUFA9","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB1","resource":"NDUFB1","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB10","resource":"NDUFB10","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB2","resource":"NDUFB2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB3","resource":"NDUFB3","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB4","resource":"NDUFB4","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB5","resource":"NDUFB5","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB6","resource":"NDUFB6","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase.","authors":["Raha S"," Myint AT"," Johnstone L"," Robinson BH."],"journal":"Free radical biology & medicine","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","id":"11864782","citationCount":45,"stringAuthors":"Raha S,  Myint AT,  Johnstone L,  Robinson BH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","resource":"11864782","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB7","resource":"NDUFB7","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB8","resource":"NDUFB8","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB9","resource":"NDUFB9","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFC1","resource":"NDUFC1","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 subunit C2","references":[{"annotatorClassName":"","article":{"title":"Regulatory loop between redox sensing of the NADH/NAD(+) ratio by Rex (YdiH) and oxidation of NADH by NADH dehydrogenase Ndh in Bacillus subtilis.","authors":["Gyan S"," Shiohira Y"," Sato I"," Takeuchi M"," Sato T."],"journal":"Journal of bacteriology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17015645","id":"17015645","citationCount":59,"stringAuthors":"Gyan S,  Shiohira Y,  Sato I,  Takeuchi M,  Sato T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17015645","resource":"17015645","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stimulation of chlororespiration by heat and high light intensity in oat plants.","authors":["Quiles MJ."],"journal":"Plant, cell & environment","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898010","id":"16898010","citationCount":36,"stringAuthors":"Quiles MJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898010","resource":"16898010","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Generation of a membrane potential by Lactococcus lactis through aerobic electron transport.","authors":["Brooijmans RJ"," Poolman B"," Schuurman-Wolters GK"," de Vos WM"," Hugenholtz J."],"journal":"Journal of bacteriology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17496098","id":"17496098","citationCount":31,"stringAuthors":"Brooijmans RJ,  Poolman B,  Schuurman-Wolters GK,  de Vos WM,  Hugenholtz J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17496098","resource":"17496098","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Association of MT-ND5 gene variation with mitochondrial respiratory control ratio and NADH dehydrogenase activity in Tibet chicken embryos.","authors":["Bao HG"," Zhao CJ"," Li JY"," Wu Ch."],"journal":"Animal genetics","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17614984","id":"17614984","citationCount":3,"stringAuthors":"Bao HG,  Zhao CJ,  Li JY,  Wu Ch."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17614984","resource":"17614984","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Ischemic preconditioning prevents in vivo hyperoxygenation in postischemic myocardium with preservation of mitochondrial oxygen consumption.","authors":["Zhu X"," Liu B"," Zhou S"," Chen YR"," Deng Y"," Zweier JL"," He G."],"journal":"American journal of physiology. Heart and circulatory physiology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17513495","id":"17513495","citationCount":19,"stringAuthors":"Zhu X,  Liu B,  Zhou S,  Chen YR,  Deng Y,  Zweier JL,  He G."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17513495","resource":"17513495","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFC2","resource":"NDUFC2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cloning of the human mitochondrial 51 kDa subunit (NDUFV1) reveals a 100% antisense homology of its 3'UTR with the 5'UTR of the gamma-interferon inducible protein (IP-30) precursor: is this a link between mitochondrial myopathy and inflammation?","authors":["Schuelke M"," Loeffen J"," Mariman E"," Smeitink J"," van den Heuvel L."],"journal":"Biochemical and biophysical research communications","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9571201","id":"9571201","citationCount":8,"stringAuthors":"Schuelke M,  Loeffen J,  Mariman E,  Smeitink J,  van den Heuvel L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9571201","resource":"9571201","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Chromosomal localization of the human gene encoding the 51-kDa subunit of mitochondrial complex I (NDUFV1) to 11q13.","authors":["Ali ST"," Duncan AM"," Schappert K"," Heng HH"," Tsui LC"," Chow W"," Robinson BH."],"journal":"Genomics","year":1993,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8288251","id":"8288251","citationCount":13,"stringAuthors":"Ali ST,  Duncan AM,  Schappert K,  Heng HH,  Tsui LC,  Chow W,  Robinson BH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8288251","resource":"8288251","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis.","authors":["Grad LI"," Lemire BD."],"journal":"Human molecular genetics","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14662656","id":"14662656","citationCount":52,"stringAuthors":"Grad LI,  Lemire BD."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14662656","resource":"14662656","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFV1","resource":"NDUFV1","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Identification of genes regulated by UV/salicylic acid.","authors":["Paunesku T"," Chang-Liu CM"," Shearin-Jones P"," Watson C"," Milton J"," Oryhon J"," Salbego D"," Milosavljevic A"," Woloschak GE."],"journal":"International journal of radiation biology","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10716640","id":"10716640","citationCount":2,"stringAuthors":"Paunesku T,  Chang-Liu CM,  Shearin-Jones P,  Watson C,  Milton J,  Oryhon J,  Salbego D,  Milosavljevic A,  Woloschak GE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10716640","resource":"10716640","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFV2","resource":"NDUFV2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFV3","resource":"NDUFV3","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS2","resource":"NDUFS2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS3","resource":"NDUFS3","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The NADH: ubiquinone oxidoreductase (complex I) of the mammalian respiratory chain and the cAMP cascade.","authors":["Papa S"," Sardanelli AM"," Scacco S"," Petruzzella V"," Technikova-Dobrova Z"," Vergari R"," Signorile A."],"journal":"Journal of bioenergetics and biomembranes","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11860175","id":"11860175","citationCount":23,"stringAuthors":"Papa S,  Sardanelli AM,  Scacco S,  Petruzzella V,  Technikova-Dobrova Z,  Vergari R,  Signorile A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11860175","resource":"11860175","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A nonsense mutation in the NDUFS4 gene encoding the 18 kDa (AQDQ) subunit of complex I abolishes assembly and activity of the complex in a patient with Leigh-like syndrome.","authors":["Petruzzella V"," Vergari R"," Puzziferri I"," Boffoli D"," Lamantea E"," Zeviani M"," Papa S."],"journal":"Human molecular genetics","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11181577","id":"11181577","citationCount":54,"stringAuthors":"Petruzzella V,  Vergari R,  Puzziferri I,  Boffoli D,  Lamantea E,  Zeviani M,  Papa S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11181577","resource":"11181577","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase.","authors":["Raha S"," Myint AT"," Johnstone L"," Robinson BH."],"journal":"Free radical biology & medicine","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","id":"11864782","citationCount":45,"stringAuthors":"Raha S,  Myint AT,  Johnstone L,  Robinson BH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","resource":"11864782","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS4","resource":"NDUFS4","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 5","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The human NADH: ubiquinone oxidoreductase NDUFS5 (15 kDa) subunit: cDNA cloning, chromosomal localization, tissue distribution and the absence of mutations in isolated complex I-deficient patients.","authors":["Loeffen J"," Smeets R"," Smeitink J"," Triepels R"," Sengers R"," Trijbels F"," van den Heuvel L."],"journal":"Journal of inherited metabolic disease","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10070614","id":"10070614","citationCount":3,"stringAuthors":"Loeffen J,  Smeets R,  Smeitink J,  Triepels R,  Sengers R,  Trijbels F,  van den Heuvel L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10070614","resource":"10070614","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS5","resource":"NDUFS5","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS6","resource":"NDUFS6","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone.","authors":["Schuler F"," Yano T"," Di Bernardo S"," Yagi T"," Yankovskaya V"," Singer TP"," Casida JE."],"journal":"Proceedings of the National Academy of Sciences of the United States of America","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10097178","id":"10097178","citationCount":51,"stringAuthors":"Schuler F,  Yano T,  Di Bernardo S,  Yagi T,  Yankovskaya V,  Singer TP,  Casida JE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10097178","resource":"10097178","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Assignment of the PSST subunit gene of human mitochondrial complex I to chromosome 19p13.","authors":["Hyslop SJ"," Duncan AM"," Pitkänen S"," Robinson BH."],"journal":"Genomics","year":1996,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8938450","id":"8938450","citationCount":8,"stringAuthors":"Hyslop SJ,  Duncan AM,  Pitkänen S,  Robinson BH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8938450","resource":"8938450","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Intimate relationships of the large and the small subunits of all nickel hydrogenases with two nuclear-encoded subunits of mitochondrial NADH: ubiquinone oxidoreductase.","authors":["Albracht SP."],"journal":"Biochimica et biophysica acta","year":1993,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8369340","id":"8369340","citationCount":22,"stringAuthors":"Albracht SP."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8369340","resource":"8369340","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS7","resource":"NDUFS7","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Learning from hydrogenases: location of a proton pump and of a second FMN in bovine NADH--ubiquinone oxidoreductase (Complex I).","authors":["Albracht SP"," Hedderich R."],"journal":"FEBS letters","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11086155","id":"11086155","citationCount":29,"stringAuthors":"Albracht SP,  Hedderich R."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11086155","resource":"11086155","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The first nuclear-encoded complex I mutation in a patient with Leigh syndrome.","authors":["Loeffen J"," Smeitink J"," Triepels R"," Smeets R"," Schuelke M"," Sengers R"," Trijbels F"," Hamel B"," Mullaart R"," van den Heuvel L."],"journal":"American journal of human genetics","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9837812","id":"9837812","citationCount":101,"stringAuthors":"Loeffen J,  Smeitink J,  Triepels R,  Smeets R,  Schuelke M,  Sengers R,  Trijbels F,  Hamel B,  Mullaart R,  van den Heuvel L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9837812","resource":"9837812","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Association of ferredoxin-NADP oxidoreductase with the chloroplastic pyridine nucleotide dehydrogenase complex in barley leaves","authors":["Jose Quiles M"," Cuello J."],"journal":"Plant physiology","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9576793","id":"9576793","citationCount":23,"stringAuthors":"Jose Quiles M,  Cuello J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9576793","resource":"9576793","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS8","resource":"NDUFS8","type":"HGNC_SYMBOL"}]},{"name":"NADH-cytochrome b5 reductase 3","references":[{"annotatorClassName":"","article":{"title":"Expression and characterization of a functional canine variant of cytochrome b5 reductase.","authors":["Roma GW"," Crowley LJ"," Barber MJ."],"journal":"Archives of biochemistry and biophysics","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16814740","id":"16814740","citationCount":5,"stringAuthors":"Roma GW,  Crowley LJ,  Barber MJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16814740","resource":"16814740","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A novel mutation of the cytochrome-b5 reductase gene in an Indian patient: the molecular basis of type I methemoglobinemia.","authors":["Nussenzveig RH"," Lingam HB"," Gaikwad A"," Zhu Q"," Jing N"," Prchal JT."],"journal":"Haematologica","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17082011","id":"17082011","citationCount":9,"stringAuthors":"Nussenzveig RH,  Lingam HB,  Gaikwad A,  Zhu Q,  Jing N,  Prchal JT."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17082011","resource":"17082011","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Structure of Physarum polycephalum cytochrome b5 reductase at 1.56 A resolution.","authors":["Kim S"," Suga M"," Ogasahara K"," Ikegami T"," Minami Y"," Yubisui T"," Tsukihara T."],"journal":"Acta crystallographica. Section F, Structural biology and crystallization communications","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17401193","id":"17401193","citationCount":3,"stringAuthors":"Kim S,  Suga M,  Ogasahara K,  Ikegami T,  Minami Y,  Yubisui T,  Tsukihara T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17401193","resource":"17401193","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Reductive detoxification of arylhydroxylamine carcinogens by human NADH cytochrome b5 reductase and cytochrome b5.","authors":["Kurian JR"," Chin NA"," Longlais BJ"," Hayes KL"," Trepanier LA."],"journal":"Chemical research in toxicology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17040106","id":"17040106","citationCount":14,"stringAuthors":"Kurian JR,  Chin NA,  Longlais BJ,  Hayes KL,  Trepanier LA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17040106","resource":"17040106","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Structure and properties of the recombinant NADH-cytochrome b5 reductase of Physarum polycephalum.","authors":["Ikegami T"," Kameyama E"," Yamamoto SY"," Minami Y"," Yubisui T."],"journal":"Bioscience, biotechnology, and biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17341833","id":"17341833","citationCount":1,"stringAuthors":"Ikegami T,  Kameyama E,  Yamamoto SY,  Minami Y,  Yubisui T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17341833","resource":"17341833","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=CYB5R3","resource":"CYB5R3","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS1","resource":"NDUFS1","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"TTD: Therapeutic Target Database.","authors":["Chen X"," Ji ZL"," Chen YZ."],"journal":"Nucleic acids research","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","id":"11752352","citationCount":104,"stringAuthors":"Chen X,  Ji ZL,  Chen YZ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","resource":"11752352","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND1","resource":"MT-ND1","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Differences in activity of cytochrome C oxidase in brain between sleep and wakefulness.","authors":["Nikonova EV"," Vijayasarathy C"," Zhang L"," Cater JR"," Galante RJ"," Ward SE"," Avadhani NG"," Pack AI."],"journal":"Sleep","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15700717","id":"15700717","citationCount":14,"stringAuthors":"Nikonova EV,  Vijayasarathy C,  Zhang L,  Cater JR,  Galante RJ,  Ward SE,  Avadhani NG,  Pack AI."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15700717","resource":"15700717","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"[The changes of gene expression in multiple myeloma treated with thalidomide].","authors":["Zhang HB"," Chen SL"," Liu JZ"," Xiao B"," Chen ZB"," Wang HJ."],"journal":"Zhonghua nei ke za zhi","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12882707","id":"12882707","citationCount":0,"stringAuthors":"Zhang HB,  Chen SL,  Liu JZ,  Xiao B,  Chen ZB,  Wang HJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12882707","resource":"12882707","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"TTD: Therapeutic Target Database.","authors":["Chen X"," Ji ZL"," Chen YZ."],"journal":"Nucleic acids research","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","id":"11752352","citationCount":104,"stringAuthors":"Chen X,  Ji ZL,  Chen YZ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","resource":"11752352","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND2","resource":"MT-ND2","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"TTD: Therapeutic Target Database.","authors":["Chen X"," Ji ZL"," Chen YZ."],"journal":"Nucleic acids research","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","id":"11752352","citationCount":104,"stringAuthors":"Chen X,  Ji ZL,  Chen YZ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","resource":"11752352","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND3","resource":"MT-ND3","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells.","authors":["Shen XY"," Zacal N"," Singh G"," Rainbow AJ."],"journal":"Photochemistry and photobiology","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15560738","id":"15560738","citationCount":16,"stringAuthors":"Shen XY,  Zacal N,  Singh G,  Rainbow AJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15560738","resource":"15560738","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Oxidative stress induces differential gene expression in a human lens epithelial cell line.","authors":["Carper DA"," Sun JK"," Iwata T"," Zigler JS"," Ibaraki N"," Lin LR"," Reddy V."],"journal":"Investigative ophthalmology & visual science","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9950599","id":"9950599","citationCount":21,"stringAuthors":"Carper DA,  Sun JK,  Iwata T,  Zigler JS,  Ibaraki N,  Lin LR,  Reddy V."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9950599","resource":"9950599","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Deletion of the structural gene for the NADH-dehydrogenase subunit 4 of Synechocystis 6803 alters respiratory properties.","authors":["Dzelzkalns VA"," Obinger C"," Regelsberger G"," Niederhauser H"," Kamensek M"," Peschek GA"," Bogorad L."],"journal":"Plant physiology","year":1994,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7846157","id":"7846157","citationCount":7,"stringAuthors":"Dzelzkalns VA,  Obinger C,  Regelsberger G,  Niederhauser H,  Kamensek M,  Peschek GA,  Bogorad L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7846157","resource":"7846157","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND4","resource":"MT-ND4","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 4L","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND4L","resource":"MT-ND4L","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 5","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Phylogenetic reconstruction of the Felidae using 16S rRNA and NADH-5 mitochondrial genes.","authors":["Johnson WE"," O'Brien SJ."],"journal":"Journal of molecular evolution","year":1997,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9071018","id":"9071018","citationCount":41,"stringAuthors":"Johnson WE,  O'Brien SJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9071018","resource":"9071018","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Association of MT-ND5 gene variation with mitochondrial respiratory control ratio and NADH dehydrogenase activity in Tibet chicken embryos.","authors":["Bao HG"," Zhao CJ"," Li JY"," Wu Ch."],"journal":"Animal genetics","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17614984","id":"17614984","citationCount":3,"stringAuthors":"Bao HG,  Zhao CJ,  Li JY,  Wu Ch."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17614984","resource":"17614984","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND5","resource":"MT-ND5","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 6","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND6","resource":"MT-ND6","type":"HGNC_SYMBOL"}]},{"name":"NADP-dependent malic enzyme","references":[{"annotatorClassName":"","article":{"title":"Determining Actinobacillus succinogenes metabolic pathways and fluxes by NMR and GC-MS analyses of 13C-labeled metabolic product isotopomers.","authors":["McKinlay JB"," Shachar-Hill Y"," Zeikus JG"," Vieille C."],"journal":"Metabolic engineering","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17197218","id":"17197218","citationCount":52,"stringAuthors":"McKinlay JB,  Shachar-Hill Y,  Zeikus JG,  Vieille C."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17197218","resource":"17197218","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ME1","resource":"ME1","type":"HGNC_SYMBOL"}]},{"name":"NADP-dependent malic enzyme, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates.","authors":["Luo C"," Wang X"," Long J"," Liu J."],"journal":"Journal of biochemical and biophysical methods","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16740313","id":"16740313","citationCount":9,"stringAuthors":"Luo C,  Wang X,  Long J,  Liu J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16740313","resource":"16740313","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Identification of cold acclimation-responsive Rhododendron genes for lipid metabolism, membrane transport and lignin biosynthesis: importance of moderately abundant ESTs in genomic studies.","authors":["Wei H"," Dhanaraj AL"," Arora R"," Rowland LJ"," Fu Y"," Sun L."],"journal":"Plant, cell & environment","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17080607","id":"17080607","citationCount":21,"stringAuthors":"Wei H,  Dhanaraj AL,  Arora R,  Rowland LJ,  Fu Y,  Sun L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17080607","resource":"17080607","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"L-2-hydroxyglutaric aciduria, a defect of metabolite repair.","authors":["Rzem R"," Vincent MF"," Van Schaftingen E"," Veiga-da-Cunha M."],"journal":"Journal of inherited metabolic disease","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17603759","id":"17603759","citationCount":52,"stringAuthors":"Rzem R,  Vincent MF,  Van Schaftingen E,  Veiga-da-Cunha M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17603759","resource":"17603759","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ME3","resource":"ME3","type":"HGNC_SYMBOL"}]},{"name":"Peroxisomal bifunctional enzyme","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=EHHADH","resource":"EHHADH","type":"HGNC_SYMBOL"}]},{"name":"Peroxisomal multifunctional enzyme type 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Binary structure of the two-domain (3R)-hydroxyacyl-CoA dehydrogenase from rat peroxisomal multifunctional enzyme type 2 at 2.38 A resolution.","authors":["Haapalainen AM"," Koski MK"," Qin YM"," Hiltunen JK"," Glumoff T."],"journal":"Structure (London, England : 1993)","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12517343","id":"12517343","citationCount":21,"stringAuthors":"Haapalainen AM,  Koski MK,  Qin YM,  Hiltunen JK,  Glumoff T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12517343","resource":"12517343","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B4","resource":"HSD17B4","type":"HGNC_SYMBOL"}]},{"name":"Pyrroline-5-carboxylate reductase 1, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Glutamine synthetase and glutamate dehydrogenase contribute differentially to proline accumulation in leaves of wheat (Triticum aestivum) seedlings exposed to different salinity.","authors":["Wang ZQ"," Yuan YZ"," Ou JQ"," Lin QH"," Zhang CF."],"journal":"Journal of plant physiology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16777263","id":"16777263","citationCount":28,"stringAuthors":"Wang ZQ,  Yuan YZ,  Ou JQ,  Lin QH,  Zhang CF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16777263","resource":"16777263","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Plant P5C reductase as a new target for aminomethylenebisphosphonates.","authors":["Forlani G"," Giberti S"," Berlicki L"," Petrollino D"," Kafarski P."],"journal":"Journal of agricultural and food chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17474756","id":"17474756","citationCount":13,"stringAuthors":"Forlani G,  Giberti S,  Berlicki L,  Petrollino D,  Kafarski P."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17474756","resource":"17474756","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PYCR1","resource":"PYCR1","type":"HGNC_SYMBOL"}]},{"name":"Pyrroline-5-carboxylate reductase 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Purification and characterization of Delta(1)-pyrroline-5-carboxylate reductase isoenzymes, indicating differential distribution in spinach (Spinacia oleracea L.) leaves.","authors":["Murahama M"," Yoshida T"," Hayashi F"," Ichino T"," Sanada Y"," Wada K."],"journal":"Plant & cell physiology","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11479381","id":"11479381","citationCount":15,"stringAuthors":"Murahama M,  Yoshida T,  Hayashi F,  Ichino T,  Sanada Y,  Wada K."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11479381","resource":"11479381","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PYCR2","resource":"PYCR2","type":"HGNC_SYMBOL"}]},{"name":"Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PDHA1","resource":"PDHA1","type":"HGNC_SYMBOL"}]},{"name":"Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PDHA2","resource":"PDHA2","type":"HGNC_SYMBOL"}]},{"name":"Pyruvate dehydrogenase E1 component subunit beta, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Regulation of pyruvate dehydrogenase in isolated rat liver mitochondria. Effects of octanoate, oxidation-reduction state, and adenosine triphosphate to adenosine diphosphate ratio.","authors":["Taylor SI"," Mukherjee C"," Jungas RL."],"journal":"The Journal of biological chemistry","year":1975,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1116996","id":"1116996","citationCount":34,"stringAuthors":"Taylor SI,  Mukherjee C,  Jungas RL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1116996","resource":"1116996","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PDHB","resource":"PDHB","type":"HGNC_SYMBOL"}]},{"name":"Retinal dehydrogenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Activities of cytosolic aldehyde dehydrogenase isozymes in colon cancer: determination using selective, fluorimetric assays.","authors":["WroczyÅ„ski P"," Nowak M"," Wierzchowski J"," Szubert A"," PolaÅ„ski J."],"journal":"Acta poloniae pharmaceutica","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16583981","id":"16583981","citationCount":3,"stringAuthors":"WroczyÅ„ski P,  Nowak M,  Wierzchowski J,  Szubert A,  PolaÅ„ski J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16583981","resource":"16583981","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal.","authors":["Russo J"," Barnes A"," Berger K"," Desgrosellier J"," Henderson J"," Kanters A"," Merkov L."],"journal":"BMC pharmacology","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11872149","id":"11872149","citationCount":10,"stringAuthors":"Russo J,  Barnes A,  Berger K,  Desgrosellier J,  Henderson J,  Kanters A,  Merkov L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11872149","resource":"11872149","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH1A1","resource":"ALDH1A1","type":"HGNC_SYMBOL"}]},{"name":"Retinal dehydrogenase 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The structure of retinal dehydrogenase type II at 2.7 A resolution: implications for retinal specificity.","authors":["Lamb AL"," Newcomer ME."],"journal":"Biochemistry","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10320326","id":"10320326","citationCount":51,"stringAuthors":"Lamb AL,  Newcomer ME."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10320326","resource":"10320326","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal.","authors":["Russo J"," Barnes A"," Berger K"," Desgrosellier J"," Henderson J"," Kanters A"," Merkov L."],"journal":"BMC pharmacology","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11872149","id":"11872149","citationCount":10,"stringAuthors":"Russo J,  Barnes A,  Berger K,  Desgrosellier J,  Henderson J,  Kanters A,  Merkov L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11872149","resource":"11872149","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH1A2","resource":"ALDH1A2","type":"HGNC_SYMBOL"}]},{"name":"Ribosyldihydronicotinamide dehydrogenase [quinone]","references":[{"annotatorClassName":"","article":{"title":"Reduction of mitomycin C is catalysed by human recombinant NRH:quinone oxidoreductase 2 using reduced nicotinamide adenine dinucleotide as an electron donating co-factor.","authors":["Jamieson D"," Tung AT"," Knox RJ"," Boddy AV."],"journal":"British journal of cancer","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17031400","id":"17031400","citationCount":12,"stringAuthors":"Jamieson D,  Tung AT,  Knox RJ,  Boddy AV."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17031400","resource":"17031400","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NQO1 and NQO2 regulation of humoral immunity and autoimmunity.","authors":["Iskander K"," Li J"," Han S"," Zheng B"," Jaiswal AK."],"journal":"The Journal of biological chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16905546","id":"16905546","citationCount":28,"stringAuthors":"Iskander K,  Li J,  Han S,  Zheng B,  Jaiswal AK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16905546","resource":"16905546","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NQO2","resource":"NQO2","type":"HGNC_SYMBOL"}]},{"name":"Short-chain specific acyl-CoA dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ACADS","resource":"ACADS","type":"HGNC_SYMBOL"}]},{"name":"Sorbitol dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"Pyridine nucleotide redox abnormalities in diabetes.","authors":["Ido Y."],"journal":"Antioxidants & redox signaling","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","id":"17508915","citationCount":36,"stringAuthors":"Ido Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","resource":"17508915","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase.","authors":["Klimacek M"," Hellmer H"," Nidetzky B."],"journal":"The Biochemical journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17343568","id":"17343568","citationCount":8,"stringAuthors":"Klimacek M,  Hellmer H,  Nidetzky B."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17343568","resource":"17343568","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SORD","resource":"SORD","type":"HGNC_SYMBOL"}]},{"name":"Steroid 17-alpha-hydroxylase/17,20 lyase","references":[{"annotatorClassName":"","article":{"title":"Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase.","authors":["Pandey AV"," Kempná P"," Hofer G"," Mullis PE"," Flück CE."],"journal":"Molecular endocrinology (Baltimore, Md.)","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17595315","id":"17595315","citationCount":49,"stringAuthors":"Pandey AV,  Kempná P,  Hofer G,  Mullis PE,  Flück CE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17595315","resource":"17595315","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=CYP17A1","resource":"CYP17A1","type":"HGNC_SYMBOL"}]},{"name":"Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Changes in gene expression associated with loss of function of the NSDHL sterol dehydrogenase in mouse embryonic fibroblasts.","authors":["Cunningham D"," Swartzlander D"," Liyanarachchi S"," Davuluri RV"," Herman GE."],"journal":"Journal of Lipid Research","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15805545","id":"15805545","citationCount":8,"stringAuthors":"Cunningham D,  Swartzlander D,  Liyanarachchi S,  Davuluri RV,  Herman GE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15805545","resource":"15805545","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NSDHL","resource":"NSDHL","type":"HGNC_SYMBOL"}]},{"name":"Succinate-semialdehyde dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH5A1","resource":"ALDH5A1","type":"HGNC_SYMBOL"}]},{"name":"Testosterone 17-beta-dehydrogenase 3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Relationship between steroids and pyridine nucleotides in the oxido-reduction catalyzed by the 17 beta-hydroxysteroid dehydrogenase purified from the porcine testicular microsomal fraction.","authors":["Inano H"," Tamaoki B."],"journal":"European journal of biochemistry","year":1975,"link":"http://www.ncbi.nlm.nih.gov/pubmed/237755","id":"237755","citationCount":9,"stringAuthors":"Inano H,  Tamaoki B."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/237755","resource":"237755","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B3","resource":"HSD17B3","type":"HGNC_SYMBOL"}]},{"name":"Trifunctional enzyme subunit alpha, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HADHA","resource":"HADHA","type":"HGNC_SYMBOL"}]},{"name":"Tyrosinase","references":[{"annotatorClassName":"","article":{"title":"Decolourization of azo dye methyl red by Saccharomyces cerevisiae MTCC 463.","authors":["Jadhav JP"," Parshetti GK"," Kalme SD"," Govindwar SP."],"journal":"Chemosphere","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17292452","id":"17292452","citationCount":47,"stringAuthors":"Jadhav JP,  Parshetti GK,  Kalme SD,  Govindwar SP."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17292452","resource":"17292452","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A potential role for cyclized quinones derived from dopamine, DOPA, and 3,4-dihydroxyphenylacetic acid in proteasomal inhibition.","authors":["Zafar KS"," Siegel D"," Ross D."],"journal":"Molecular pharmacology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16790533","id":"16790533","citationCount":38,"stringAuthors":"Zafar KS,  Siegel D,  Ross D."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16790533","resource":"16790533","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=TYR","resource":"TYR","type":"HGNC_SYMBOL"}]},{"name":"UDP-glucose 6-dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Regulatory mechanisms of UDP-glucuronic acid biosynthesis in cultured human skin fibroblasts.","authors":["Castellani AA"," De Luca G"," Rindi S"," Salvini R"," Tira ME."],"journal":"The Italian journal of biochemistry","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3804697","id":"3804697","citationCount":2,"stringAuthors":"Castellani AA,  De Luca G,  Rindi S,  Salvini R,  Tira ME."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3804697","resource":"3804697","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Mechanism of cadmium-decreased glucuronidation in the rat.","authors":["Alary J"," Cravedi JP"," Baradat M"," Carrera G."],"journal":"Biochemical pharmacology","year":1992,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1472079","id":"1472079","citationCount":3,"stringAuthors":"Alary J,  Cravedi JP,  Baradat M,  Carrera G."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1472079","resource":"1472079","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=UGDH","resource":"UGDH","type":"HGNC_SYMBOL"}]}]}]
\ No newline at end of file
+[{"bloodBrainBarrier":"YES","brandNames":[],"description":"NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). It forms NADP with the addition of a phosphate group to the 2' position of the adenosyl nucleotide through an ester linkage. (Dorland, 27th ed) ","id":"NADH","name":"NADH","references":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.drugbank.ca/drugs/DB00157","resource":"DB00157","type":"DRUGBANK"}],"synonyms":[],"targets":[{"name":"D-beta-hydroxybutyrate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A chemiluminescence-flow injection analysis of serum 3-hydroxybutyrate using a bioreactor consisting of 3-hydroxybutyrate dehydrogenase and NADH oxidase.","authors":["Tabata M"," Totani M."],"journal":"Analytical biochemistry","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8533882","id":"8533882","citationCount":5,"stringAuthors":"Tabata M,  Totani M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8533882","resource":"8533882","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Coenzyme binding by 3-hydroxybutyrate dehydrogenase, a lipid-requiring enzyme: lecithin acts as an allosteric modulator to enhance the affinity for coenzyme.","authors":["Rudy B"," Dubois H"," Mink R"," Trommer WE"," McIntyre JO"," Fleischer S."],"journal":"Biochemistry","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2550053","id":"2550053","citationCount":8,"stringAuthors":"Rudy B,  Dubois H,  Mink R,  Trommer WE,  McIntyre JO,  Fleischer S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2550053","resource":"2550053","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Activities of NAD-specific and NADP-specific isocitrate dehydrogenases in rat-liver mitochondria. Studies with D-threo-alpha-methylisocitrate.","authors":["Smith CM"," Plaut GW."],"journal":"European journal of biochemistry","year":1979,"link":"http://www.ncbi.nlm.nih.gov/pubmed/38961","id":"38961","citationCount":11,"stringAuthors":"Smith CM,  Plaut GW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/38961","resource":"38961","type":"PUBMED"}],"targetElements":[{"id":329170,"modelId":15781,"type":"ALIAS"}],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=BDH1","resource":"BDH1","type":"HGNC_SYMBOL"}]},{"name":"11-cis retinol dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"Analysis of the NADH-dependent retinaldehyde reductase activity of amphioxus retinol dehydrogenase enzymes enhances our understanding of the evolution of the retinol dehydrogenase family.","authors":["Dalfó D"," Marqués N"," Albalat R."],"journal":"The FEBS journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17608724","id":"17608724","citationCount":10,"stringAuthors":"Dalfó D,  Marqués N,  Albalat R."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17608724","resource":"17608724","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=RDH5","resource":"RDH5","type":"HGNC_SYMBOL"}]},{"name":"15-hydroxyprostaglandin dehydrogenase [NAD(+)]","references":[{"annotatorClassName":"","article":{"title":"Corticotropin-releasing hormone receptor type 1 and type 2 mediate differential effects on 15-hydroxy prostaglandin dehydrogenase expression in cultured human chorion trophoblasts.","authors":["Gao L"," He P"," Sha J"," Liu C"," Dai L"," Hui N"," Ni X."],"journal":"Endocrinology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17463062","id":"17463062","citationCount":10,"stringAuthors":"Gao L,  He P,  Sha J,  Liu C,  Dai L,  Hui N,  Ni X."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17463062","resource":"17463062","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HPGD","resource":"HPGD","type":"HGNC_SYMBOL"}]},{"name":"2-oxoglutarate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"The tricarboxylic acid cycle, an ancient metabolic network with a novel twist.","authors":["Mailloux RJ"," Bériault R"," Lemire J"," Singh R"," Chénier DR"," Hamel RD"," Appanna VD."],"journal":"PloS one","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17668068","id":"17668068","citationCount":101,"stringAuthors":"Mailloux RJ,  Bériault R,  Lemire J,  Singh R,  Chénier DR,  Hamel RD,  Appanna VD."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17668068","resource":"17668068","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=OGDH","resource":"OGDH","type":"HGNC_SYMBOL"}]},{"name":"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of testosterone biosynthesis by ethanol: multiple sites and mechanisms in dispersed Leydig cells.","authors":["Widenius TV"," Orava MM"," Vihko RK"," Ylikahri RH"," Eriksson CJ."],"journal":"Journal of steroid biochemistry","year":1987,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3476810","id":"3476810","citationCount":14,"stringAuthors":"Widenius TV,  Orava MM,  Vihko RK,  Ylikahri RH,  Eriksson CJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3476810","resource":"3476810","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Affinity alkylation of human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase by 2 alpha-bromoacetoxyprogesterone: evidence for separate dehydrogenase and isomerase sites on one protein.","authors":["Thomas JL"," Myers RP"," Rosik LO"," Strickler RC."],"journal":"Journal of steroid biochemistry","year":1990,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2362440","id":"2362440","citationCount":4,"stringAuthors":"Thomas JL,  Myers RP,  Rosik LO,  Strickler RC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2362440","resource":"2362440","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Testicular and adrenal 3 beta-hydroxy-5-ene-steroid dehydrogenase and 5-ene-4-ene isomerase.","authors":["Ishii-Ohba H"," Inano H"," Tamaoki B."],"journal":"Journal of steroid biochemistry","year":1987,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2961942","id":"2961942","citationCount":10,"stringAuthors":"Ishii-Ohba H,  Inano H,  Tamaoki B."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2961942","resource":"2961942","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD3B1","resource":"HSD3B1","type":"HGNC_SYMBOL"}]},{"name":"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of testosterone biosynthesis by ethanol: multiple sites and mechanisms in dispersed Leydig cells.","authors":["Widenius TV"," Orava MM"," Vihko RK"," Ylikahri RH"," Eriksson CJ."],"journal":"Journal of steroid biochemistry","year":1987,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3476810","id":"3476810","citationCount":14,"stringAuthors":"Widenius TV,  Orava MM,  Vihko RK,  Ylikahri RH,  Eriksson CJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3476810","resource":"3476810","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Studies of the human testis. VII. Conversion of pregnenolone to progesterone.","authors":["Fan DF"," Troen P."],"journal":"The Journal of clinical endocrinology and metabolism","year":1975,"link":"http://www.ncbi.nlm.nih.gov/pubmed/239964","id":"239964","citationCount":8,"stringAuthors":"Fan DF,  Troen P."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/239964","resource":"239964","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Analysis of coenzyme binding by human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase using 5'-[p-(fluorosulfonyl)benzoyl]adenosine, an affinity labeling cofactor analog.","authors":["Thomas JL"," Myers RP"," Strickler RC."],"journal":"The Journal of steroid biochemistry and molecular biology","year":1991,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1911436","id":"1911436","citationCount":3,"stringAuthors":"Thomas JL,  Myers RP,  Strickler RC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1911436","resource":"1911436","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD3B2","resource":"HSD3B2","type":"HGNC_SYMBOL"}]},{"name":"3-hydroxy-3-methylglutaryl-coenzyme A reductase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Improved posthypoxic recovery in vitro on treatment with drugs used for secondary stroke prevention.","authors":["Huber R"," Riepe MW."],"journal":"Neuropharmacology","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15755483","id":"15755483","citationCount":1,"stringAuthors":"Huber R,  Riepe MW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15755483","resource":"15755483","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii.","authors":["Hedl M"," Rodwell VW."],"journal":"Protein science : a publication of the Protein Society","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15152097","id":"15152097","citationCount":10,"stringAuthors":"Hedl M,  Rodwell VW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15152097","resource":"15152097","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"3-hydroxy-3-methylglutaryl-coenzyme A reductase in the lobster mandibular organ: regulation by the eyestalk.","authors":["Li S"," Wagner CA"," Friesen JA"," Borst DW."],"journal":"General and comparative endocrinology","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14511985","id":"14511985","citationCount":13,"stringAuthors":"Li S,  Wagner CA,  Friesen JA,  Borst DW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14511985","resource":"14511985","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HMGCR","resource":"HMGCR","type":"HGNC_SYMBOL"}]},{"name":"3-hydroxyacyl-CoA dehydrogenase type-2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B10","resource":"HSD17B10","type":"HGNC_SYMBOL"}]},{"name":"3-hydroxyisobutyrate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HIBADH","resource":"HIBADH","type":"HGNC_SYMBOL"}]},{"name":"3-keto-steroid reductase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B7","resource":"HSD17B7","type":"HGNC_SYMBOL"}]},{"name":"4-trimethylaminobutyraldehyde dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Properties of gamma-aminobutyraldehyde dehydrogenase from Escherichia coli.","authors":["Prieto MI"," Martin J"," Balaña-Fouce R"," Garrido-Pertierra A."],"journal":"Biochimie","year":1987,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3129020","id":"3129020","citationCount":5,"stringAuthors":"Prieto MI,  Martin J,  Balaña-Fouce R,  Garrido-Pertierra A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3129020","resource":"3129020","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Purification and kinetic characterization of gamma-aminobutyraldehyde dehydrogenase from rat liver.","authors":["Testore G"," Colombatto S"," Silvagno F"," Bedino S."],"journal":"The international journal of biochemistry & cell biology","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7584606","id":"7584606","citationCount":4,"stringAuthors":"Testore G,  Colombatto S,  Silvagno F,  Bedino S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7584606","resource":"7584606","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH9A1","resource":"ALDH9A1","type":"HGNC_SYMBOL"}]},{"name":"7-dehydrocholesterol reductase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DHCR7","resource":"DHCR7","type":"HGNC_SYMBOL"}]},{"name":"Acyl carrier protein, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFAB1","resource":"NDUFAB1","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase 1A","references":[{"annotatorClassName":"","article":{"title":"Synthetic lethal and biochemical analyses of NAD and NADH kinases in Saccharomyces cerevisiae establish separation of cellular functions.","authors":["Bieganowski P"," Seidle HF"," Wojcik M"," Brenner C."],"journal":"The Journal of biological chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16760478","id":"16760478","citationCount":25,"stringAuthors":"Bieganowski P,  Seidle HF,  Wojcik M,  Brenner C."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16760478","resource":"16760478","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Two highly divergent alcohol dehydrogenases of melon exhibit fruit ripening-specific expression and distinct biochemical characteristics.","authors":["Manríquez D"," El-Sharkawy I"," Flores FB"," El-Yahyaoui F"," Regad F"," Bouzayen M"," Latché A"," Pech JC."],"journal":"Plant molecular biology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16897483","id":"16897483","citationCount":34,"stringAuthors":"Manríquez D,  El-Sharkawy I,  Flores FB,  El-Yahyaoui F,  Regad F,  Bouzayen M,  Latché A,  Pech JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16897483","resource":"16897483","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH1A","resource":"ADH1A","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase 1B","references":[{"annotatorClassName":"","article":{"title":"Two highly divergent alcohol dehydrogenases of melon exhibit fruit ripening-specific expression and distinct biochemical characteristics.","authors":["Manríquez D"," El-Sharkawy I"," Flores FB"," El-Yahyaoui F"," Regad F"," Bouzayen M"," Latché A"," Pech JC."],"journal":"Plant molecular biology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16897483","id":"16897483","citationCount":34,"stringAuthors":"Manríquez D,  El-Sharkawy I,  Flores FB,  El-Yahyaoui F,  Regad F,  Bouzayen M,  Latché A,  Pech JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16897483","resource":"16897483","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH1B","resource":"ADH1B","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase 1C","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Specificity of human alcohol dehydrogenase 1C*2 (gamma2gamma2) for steroids and simulation of the uncompetitive inhibition of ethanol metabolism.","authors":["Plapp BV"," Berst KB."],"journal":"Chemico-biological interactions","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12604203","id":"12604203","citationCount":3,"stringAuthors":"Plapp BV,  Berst KB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12604203","resource":"12604203","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH1C","resource":"ADH1C","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase 4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Biochemical basis of mitochondrial acetaldehyde dismutation in Saccharomyces cerevisiae.","authors":["Thielen J"," Ciriacy M."],"journal":"Journal of bacteriology","year":1991,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1938903","id":"1938903","citationCount":3,"stringAuthors":"Thielen J,  Ciriacy M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1938903","resource":"1938903","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Mouse alcohol dehydrogenase 4: kinetic mechanism, substrate specificity and simulation of effects of ethanol on retinoid metabolism.","authors":["Plapp BV"," Mitchell JL"," Berst KB."],"journal":"Chemico-biological interactions","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11306066","id":"11306066","citationCount":4,"stringAuthors":"Plapp BV,  Mitchell JL,  Berst KB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11306066","resource":"11306066","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Ethanol-induced inhibition of testosterone biosynthesis in vitro: lack of acetaldehyde effect.","authors":["Widenius TV."],"journal":"Alcohol and alcoholism (Oxford, Oxfordshire)","year":1987,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3593480","id":"3593480","citationCount":2,"stringAuthors":"Widenius TV."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3593480","resource":"3593480","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH4","resource":"ADH4","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase class 4 mu/sigma chain","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Analysis of the NADH-dependent retinaldehyde reductase activity of amphioxus retinol dehydrogenase enzymes enhances our understanding of the evolution of the retinol dehydrogenase family.","authors":["Dalfó D"," Marqués N"," Albalat R."],"journal":"The FEBS journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17608724","id":"17608724","citationCount":10,"stringAuthors":"Dalfó D,  Marqués N,  Albalat R."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17608724","resource":"17608724","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Identification and immunohistochemistry of retinol dehydrogenase from bovine retinal pigment epithelium.","authors":["Suzuki Y"," Ishiguro S"," Tamai M."],"journal":"Biochimica et biophysica acta","year":1993,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8490052","id":"8490052","citationCount":12,"stringAuthors":"Suzuki Y,  Ishiguro S,  Tamai M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8490052","resource":"8490052","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Effect of thyroid hormone on the alcohol dehydrogenase activities in rat tissues.","authors":["Kim DS"," Lee CB"," Park YS"," Ahn YH"," Kim TW"," Kee CS"," Kang JS"," Om AS."],"journal":"Journal of Korean medical science","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11410692","id":"11410692","citationCount":1,"stringAuthors":"Kim DS,  Lee CB,  Park YS,  Ahn YH,  Kim TW,  Kee CS,  Kang JS,  Om AS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11410692","resource":"11410692","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH7","resource":"ADH7","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase class-3","references":[{"annotatorClassName":"","article":{"title":"High-resolution structures of formate dehydrogenase from Candida boidinii.","authors":["Schirwitz K"," Schmidt A"," Lamzin VS."],"journal":"Protein science : a publication of the Protein Society","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17525463","id":"17525463","citationCount":24,"stringAuthors":"Schirwitz K,  Schmidt A,  Lamzin VS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17525463","resource":"17525463","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"D-mannitol production by resting state whole cell biotrans-formation of D-fructose by heterologous mannitol and formate dehydrogenase gene expression in Bacillus megaterium.","authors":["Bäumchen C"," Roth AH"," Biedendieck R"," Malten M"," Follmann M"," Sahm H"," Bringer-Meyer S"," Jahn D."],"journal":"Biotechnology journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17619232","id":"17619232","citationCount":11,"stringAuthors":"Bäumchen C,  Roth AH,  Biedendieck R,  Malten M,  Follmann M,  Sahm H,  Bringer-Meyer S,  Jahn D."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17619232","resource":"17619232","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Enhanced activity of 3alpha-hydroxysteroid dehydrogenase by addition of the co-solvent 1-butyl-3-methylimidazolium (L)-lactate in aqueous phase of biphasic systems for reductive production of steroids.","authors":["Okochi M"," Nakagawa I"," Kobayashi T"," Hayashi S"," Furusaki S"," Honda H."],"journal":"Journal of biotechnology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17092593","id":"17092593","citationCount":7,"stringAuthors":"Okochi M,  Nakagawa I,  Kobayashi T,  Hayashi S,  Furusaki S,  Honda H."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17092593","resource":"17092593","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Logic gates and elementary computing by enzymes.","authors":["Baron R"," Lioubashevski O"," Katz E"," Niazov T"," Willner I."],"journal":"The journal of physical chemistry. A","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16821840","id":"16821840","citationCount":36,"stringAuthors":"Baron R,  Lioubashevski O,  Katz E,  Niazov T,  Willner I."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16821840","resource":"16821840","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH5","resource":"ADH5","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase X, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH1B1","resource":"ALDH1B1","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase family 1 member A3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Characterization of retinaldehyde dehydrogenase 3.","authors":["Graham CE"," Brocklehurst K"," Pickersgill RW"," Warren MJ."],"journal":"The Biochemical journal","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16241904","id":"16241904","citationCount":17,"stringAuthors":"Graham CE,  Brocklehurst K,  Pickersgill RW,  Warren MJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16241904","resource":"16241904","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH1A3","resource":"ALDH1A3","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase family 3 member B1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH3B1","resource":"ALDH3B1","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase family 3 member B2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH3B2","resource":"ALDH3B2","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase, dimeric NADP-preferring","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Activities of cytosolic aldehyde dehydrogenase isozymes in colon cancer: determination using selective, fluorimetric assays.","authors":["WroczyÅ„ski P"," Nowak M"," Wierzchowski J"," Szubert A"," PolaÅ„ski J."],"journal":"Acta poloniae pharmaceutica","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16583981","id":"16583981","citationCount":3,"stringAuthors":"WroczyÅ„ski P,  Nowak M,  Wierzchowski J,  Szubert A,  PolaÅ„ski J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16583981","resource":"16583981","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH3A1","resource":"ALDH3A1","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective.","authors":["Quintanilla ME"," Tampier L"," Sapag A"," Gerdtzen Z"," Israel Y."],"journal":"American journal of physiology. Endocrinology and metabolism","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17488809","id":"17488809","citationCount":17,"stringAuthors":"Quintanilla ME,  Tampier L,  Sapag A,  Gerdtzen Z,  Israel Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17488809","resource":"17488809","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake.","authors":["Quintanilla ME"," Israel Y"," Sapag A"," Tampier L."],"journal":"Addiction biology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16961761","id":"16961761","citationCount":56,"stringAuthors":"Quintanilla ME,  Israel Y,  Sapag A,  Tampier L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16961761","resource":"16961761","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH2","resource":"ALDH2","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"Journal of steroid biochemistry","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","id":"2615366","citationCount":0,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","resource":"2615366","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Microsomal 20 alpha-hydroxysteroid dehydrogenase activity for progesterone in human placenta.","authors":["Fukuda T"," Hirato K"," Yanaihara T"," Nakayama T."],"journal":"Endocrinologia japonica","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","id":"3463506","citationCount":2,"stringAuthors":"Fukuda T,  Hirato K,  Yanaihara T,  Nakayama T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","resource":"3463506","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene.","authors":["Burczynski ME"," Sridhar GR"," Palackal NT"," Penning TM."],"journal":"The Journal of biological chemistry","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11060293","id":"11060293","citationCount":72,"stringAuthors":"Burczynski ME,  Sridhar GR,  Palackal NT,  Penning TM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11060293","resource":"11060293","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C1","resource":"AKR1C1","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells.","authors":["Rizner TL"," Lin HK"," Peehl DM"," Steckelbroeck S"," Bauman DR"," Penning TM."],"journal":"Endocrinology","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12810547","id":"12810547","citationCount":65,"stringAuthors":"Rizner TL,  Lin HK,  Peehl DM,  Steckelbroeck S,  Bauman DR,  Penning TM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12810547","resource":"12810547","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Kinetics of allopregnanolone formation catalyzed by human 3 alpha-hydroxysteroid dehydrogenase type III (AKR1C2).","authors":["Trauger JW"," Jiang A"," Stearns BA"," LoGrasso PV."],"journal":"Biochemistry","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12416991","id":"12416991","citationCount":40,"stringAuthors":"Trauger JW,  Jiang A,  Stearns BA,  LoGrasso PV."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12416991","resource":"12416991","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C2","resource":"AKR1C2","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"Journal of steroid biochemistry","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","id":"2615366","citationCount":0,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","resource":"2615366","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer between progesterone and cofactor by human placental estradiol-17 beta dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"The Journal of steroid biochemistry and molecular biology","year":1990,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2146972","id":"2146972","citationCount":0,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2146972","resource":"2146972","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Bioluminescent assay of femtomole levels of estrone and estradiol.","authors":["Nicolas JC"," Boussioux AM"," Boularan AM"," Descomps B"," Crastes de Paulet A."],"journal":"Analytical biochemistry","year":1983,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6584048","id":"6584048","citationCount":5,"stringAuthors":"Nicolas JC,  Boussioux AM,  Boularan AM,  Descomps B,  Crastes de Paulet A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6584048","resource":"6584048","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C3","resource":"AKR1C3","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Purification and characterization of oxidoreductases-catalyzing carbonyl reduction of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human liver cytosol.","authors":["Atalla A"," Breyer-Pfaff U"," Maser E."],"journal":"Xenobiotica; the fate of foreign compounds in biological systems","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11037109","id":"11037109","citationCount":29,"stringAuthors":"Atalla A,  Breyer-Pfaff U,  Maser E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11037109","resource":"11037109","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C4","resource":"AKR1C4","type":"HGNC_SYMBOL"}]},{"name":"Aldose reductase","references":[{"annotatorClassName":"","article":{"title":"Pyridine nucleotide redox abnormalities in diabetes.","authors":["Ido Y."],"journal":"Antioxidants & redox signaling","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","id":"17508915","citationCount":36,"stringAuthors":"Ido Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","resource":"17508915","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Vitamin C. Biosynthesis, recycling and degradation in mammals.","authors":["Linster CL"," Van Schaftingen E."],"journal":"The FEBS journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17222174","id":"17222174","citationCount":175,"stringAuthors":"Linster CL,  Van Schaftingen E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17222174","resource":"17222174","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1B1","resource":"AKR1B1","type":"HGNC_SYMBOL"}]},{"name":"Alpha-aminoadipic semialdehyde dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes.","authors":["de La Fuente JL"," Rumbero A"," Martín JF"," Liras P."],"journal":"The Biochemical journal","year":1997,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9355735","id":"9355735","citationCount":10,"stringAuthors":"de La Fuente JL,  Rumbero A,  Martín JF,  Liras P."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9355735","resource":"9355735","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH7A1","resource":"ALDH7A1","type":"HGNC_SYMBOL"}]},{"name":"Alpha-aminoadipic semialdehyde synthase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Determinants of substrate specificity for saccharopine dehydrogenase from Saccharomyces cerevisiae.","authors":["Xu H"," West AH"," Cook PF."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17542618","id":"17542618","citationCount":3,"stringAuthors":"Xu H,  West AH,  Cook PF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17542618","resource":"17542618","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Overall kinetic mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae.","authors":["Xu H"," West AH"," Cook PF."],"journal":"Biochemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17002315","id":"17002315","citationCount":12,"stringAuthors":"Xu H,  West AH,  Cook PF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17002315","resource":"17002315","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A proposed proton shuttle mechanism for saccharopine dehydrogenase from Saccharomyces cerevisiae.","authors":["Xu H"," Alguindigue SS"," West AH"," Cook PF."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17223709","id":"17223709","citationCount":9,"stringAuthors":"Xu H,  Alguindigue SS,  West AH,  Cook PF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17223709","resource":"17223709","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AASS","resource":"AASS","type":"HGNC_SYMBOL"}]},{"name":"Aminomethyltransferase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AMT","resource":"AMT","type":"HGNC_SYMBOL"}]},{"name":"Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MTHFD2","resource":"MTHFD2","type":"HGNC_SYMBOL"}]},{"name":"Biliverdin reductase A","references":[{"annotatorClassName":"","article":{"title":"Activation of biliverdin-IXalpha reductase by inorganic phosphate and related anions.","authors":["Franklin E"," Browne S"," Hayes J"," Boland C"," Dunne A"," Elliot G"," Mantle TJ."],"journal":"The Biochemical journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17402939","id":"17402939","citationCount":4,"stringAuthors":"Franklin E,  Browne S,  Hayes J,  Boland C,  Dunne A,  Elliot G,  Mantle TJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17402939","resource":"17402939","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=BLVRA","resource":"BLVRA","type":"HGNC_SYMBOL"}]},{"name":"C-1-tetrahydrofolate synthase, cytoplasmic","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MTHFD1","resource":"MTHFD1","type":"HGNC_SYMBOL"}]},{"name":"Corticosteroid 11-beta-dehydrogenase isozyme 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Metabolism of dexamethasone in the human kidney: nicotinamide adenine dinucleotide-dependent 11beta-reduction.","authors":["Diederich S"," Hanke B"," Oelkers W"," Bähr V."],"journal":"The Journal of Clinical Endocrinology and Metabolism","year":1997,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9141556","id":"9141556","citationCount":15,"stringAuthors":"Diederich S,  Hanke B,  Oelkers W,  Bähr V."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9141556","resource":"9141556","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Comparison of 11 beta-hydroxysteroid dehydrogenase in spontaneously hypertensive and Wistar-Kyoto rats.","authors":["Hermans JJ"," Steckel B"," Thijssen HH"," Janssen BJ"," Netter KJ"," Maser E."],"journal":"Steroids","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8585102","id":"8585102","citationCount":3,"stringAuthors":"Hermans JJ,  Steckel B,  Thijssen HH,  Janssen BJ,  Netter KJ,  Maser E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8585102","resource":"8585102","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD11B1","resource":"HSD11B1","type":"HGNC_SYMBOL"}]},{"name":"Corticosteroid 11-beta-dehydrogenase isozyme 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Localization of an 11 beta hydroxysteroid dehydrogenase activity to the distal nephron. Evidence for the existence of two species of dehydrogenase in the rat kidney.","authors":["Mercer WR"," Krozowski ZS."],"journal":"Endocrinology","year":1992,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1727721","id":"1727721","citationCount":62,"stringAuthors":"Mercer WR,  Krozowski ZS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1727721","resource":"1727721","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Comparison of 11 beta-hydroxysteroid dehydrogenase in spontaneously hypertensive and Wistar-Kyoto rats.","authors":["Hermans JJ"," Steckel B"," Thijssen HH"," Janssen BJ"," Netter KJ"," Maser E."],"journal":"Steroids","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8585102","id":"8585102","citationCount":3,"stringAuthors":"Hermans JJ,  Steckel B,  Thijssen HH,  Janssen BJ,  Netter KJ,  Maser E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8585102","resource":"8585102","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD11B2","resource":"HSD11B2","type":"HGNC_SYMBOL"}]},{"name":"Cysteine dioxygenase type 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=CDO1","resource":"CDO1","type":"HGNC_SYMBOL"}]},{"name":"Cytochrome P450 4A11","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cytochrome P450 4A, peroxisomal enzymes and nicotinamide cofactors in koala liver.","authors":["Ngo S"," Kong S"," Kirlich A"," McKinnon RA"," Stupans I."],"journal":"Comparative biochemistry and physiology. Toxicology & pharmacology : CBP","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11246504","id":"11246504","citationCount":6,"stringAuthors":"Ngo S,  Kong S,  Kirlich A,  McKinnon RA,  Stupans I."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11246504","resource":"11246504","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=CYP4A11","resource":"CYP4A11","type":"HGNC_SYMBOL"}]},{"name":"D-3-phosphoglycerate dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A new family of 2-hydroxyacid dehydrogenases.","authors":["Grant GA."],"journal":"Biochemical and biophysical research communications","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2692566","id":"2692566","citationCount":37,"stringAuthors":"Grant GA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2692566","resource":"2692566","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Serine biosynthesis in human hair follicles by the phosphorylated pathway: follicular 3-phosphoglycerate dehydrogenase.","authors":["Goldsmith LA"," O'Barr T."],"journal":"The Journal of investigative dermatology","year":1976,"link":"http://www.ncbi.nlm.nih.gov/pubmed/945314","id":"945314","citationCount":4,"stringAuthors":"Goldsmith LA,  O'Barr T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/945314","resource":"945314","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cofactor binding to Escherichia coli D-3-phosphoglycerate dehydrogenase induces multiple conformations which alter effector binding.","authors":["Grant GA"," Hu Z"," Xu XL."],"journal":"The Journal of biological chemistry","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12183470","id":"12183470","citationCount":9,"stringAuthors":"Grant GA,  Hu Z,  Xu XL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12183470","resource":"12183470","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PHGDH","resource":"PHGDH","type":"HGNC_SYMBOL"}]},{"name":"Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Crystal structure of Thermus thermophilus Delta1-pyrroline-5-carboxylate dehydrogenase.","authors":["Inagaki E"," Ohshima N"," Takahashi H"," Kuroishi C"," Yokoyama S"," Tahirov TH."],"journal":"Journal of molecular biology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16934832","id":"16934832","citationCount":35,"stringAuthors":"Inagaki E,  Ohshima N,  Takahashi H,  Kuroishi C,  Yokoyama S,  Tahirov TH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16934832","resource":"16934832","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH4A1","resource":"ALDH4A1","type":"HGNC_SYMBOL"}]},{"name":"Dihydrofolate reductase","references":[{"annotatorClassName":"","article":{"title":"Proteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis.","authors":["Argyrou A"," Jin L"," Siconilfi-Baez L"," Angeletti RH"," Blanchard JS."],"journal":"Biochemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17115689","id":"17115689","citationCount":38,"stringAuthors":"Argyrou A,  Jin L,  Siconilfi-Baez L,  Angeletti RH,  Blanchard JS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17115689","resource":"17115689","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence.","authors":["Vickers TJ"," Orsomando G"," de la Garza RD"," Scott DA"," Kang SO"," Hanson AD"," Beverley SM."],"journal":"The Journal of biological chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17032644","id":"17032644","citationCount":13,"stringAuthors":"Vickers TJ,  Orsomando G,  de la Garza RD,  Scott DA,  Kang SO,  Hanson AD,  Beverley SM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17032644","resource":"17032644","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DHFR","resource":"DHFR","type":"HGNC_SYMBOL"}]},{"name":"Dihydrolipoyl dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Histochemical staining and quantification of dihydrolipoamide dehydrogenase diaphorase activity using blue native PAGE.","authors":["Yan LJ"," Yang SH"," Shu H"," Prokai L"," Forster MJ."],"journal":"Electrophoresis","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17315258","id":"17315258","citationCount":25,"stringAuthors":"Yan LJ,  Yang SH,  Shu H,  Prokai L,  Forster MJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17315258","resource":"17315258","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Trypanosoma cruzi dihydrolipoamide dehydrogenase as target for phenothiazine cationic radicals. Effect of antioxidants.","authors":["Gutiérrez-Correa J."],"journal":"Current drug targets","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17017892","id":"17017892","citationCount":3,"stringAuthors":"Gutiérrez-Correa J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17017892","resource":"17017892","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A novel branched-chain amino acid metabolon. Protein-protein interactions in a supramolecular complex.","authors":["Islam MM"," Wallin R"," Wynn RM"," Conway M"," Fujii H"," Mobley JA"," Chuang DT"," Hutson SM."],"journal":"The Journal of biological chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17314104","id":"17314104","citationCount":32,"stringAuthors":"Islam MM,  Wallin R,  Wynn RM,  Conway M,  Fujii H,  Mobley JA,  Chuang DT,  Hutson SM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17314104","resource":"17314104","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DLD","resource":"DLD","type":"HGNC_SYMBOL"}]},{"name":"Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis.","authors":["Shi S"," Ehrt S."],"journal":"Infection and immunity","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16368957","id":"16368957","citationCount":40,"stringAuthors":"Shi S,  Ehrt S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16368957","resource":"16368957","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DLAT","resource":"DLAT","type":"HGNC_SYMBOL"}]},{"name":"Dihydropteridine reductase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Determination of NADPH-specific dihydropteridine reductase in extract from human, monkey, and bovine livers by single radial immunodiffusion: selective assay differentiating NADPH- and NADH-specific enzymes.","authors":["Nakanishi N"," Ozawa K"," Yamada S."],"journal":"Journal of biochemistry","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3086306","id":"3086306","citationCount":1,"stringAuthors":"Nakanishi N,  Ozawa K,  Yamada S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3086306","resource":"3086306","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Spectral studies of the interaction of the substrate 'quinonoid' 6-methyl dihydropterine and the coenzyme NADH used as marker in the dihydropteridine reductase assay.","authors":["van der Heiden C"," Brink W."],"journal":"Journal of inherited metabolic disease","year":1982,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6820434","id":"6820434","citationCount":0,"stringAuthors":"van der Heiden C,  Brink W."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6820434","resource":"6820434","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NADH-ferric reductase activity associated with dihydropteridine reductase.","authors":["Lee PL"," Halloran C"," Cross AR"," Beutler E."],"journal":"Biochemical and biophysical research communications","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10814540","id":"10814540","citationCount":3,"stringAuthors":"Lee PL,  Halloran C,  Cross AR,  Beutler E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10814540","resource":"10814540","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=QDPR","resource":"QDPR","type":"HGNC_SYMBOL"}]},{"name":"Estradiol 17-beta-dehydrogenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"Journal of steroid biochemistry","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","id":"2615366","citationCount":0,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","resource":"2615366","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Microsomal 20 alpha-hydroxysteroid dehydrogenase activity for progesterone in human placenta.","authors":["Fukuda T"," Hirato K"," Yanaihara T"," Nakayama T."],"journal":"Endocrinologia japonica","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","id":"3463506","citationCount":2,"stringAuthors":"Fukuda T,  Hirato K,  Yanaihara T,  Nakayama T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","resource":"3463506","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The 20 alpha-hydroxysteroid dehydrogenase of Streptomyces hydrogenans.","authors":["Rimsay RL"," Murphy GW"," Martin CJ"," Orr JC."],"journal":"European journal of biochemistry","year":1988,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3164265","id":"3164265","citationCount":1,"stringAuthors":"Rimsay RL,  Murphy GW,  Martin CJ,  Orr JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3164265","resource":"3164265","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B1","resource":"HSD17B1","type":"HGNC_SYMBOL"}]},{"name":"Estradiol 17-beta-dehydrogenase 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Microsomal 20 alpha-hydroxysteroid dehydrogenase activity for progesterone in human placenta.","authors":["Fukuda T"," Hirato K"," Yanaihara T"," Nakayama T."],"journal":"Endocrinologia japonica","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","id":"3463506","citationCount":2,"stringAuthors":"Fukuda T,  Hirato K,  Yanaihara T,  Nakayama T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3463506","resource":"3463506","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"Journal of steroid biochemistry","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","id":"2615366","citationCount":0,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2615366","resource":"2615366","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Prostaglandin-E2 9-reductase from corpus luteum of pseudopregnant rabbit is a member of the aldo-keto reductase superfamily featuring 20 alpha-hydroxysteroid dehydrogenase activity.","authors":["Wintergalen N"," Thole HH"," Galla HJ"," Schlegel W."],"journal":"European journal of biochemistry","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8529651","id":"8529651","citationCount":22,"stringAuthors":"Wintergalen N,  Thole HH,  Galla HJ,  Schlegel W."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8529651","resource":"8529651","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B2","resource":"HSD17B2","type":"HGNC_SYMBOL"}]},{"name":"Estradiol 17-beta-dehydrogenase 8","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B8","resource":"HSD17B8","type":"HGNC_SYMBOL"}]},{"name":"Fatty aldehyde dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Mechanism of a long-chain fatty aldehyde dehydrogenase induced during the development of bioluminescence in Beneckea harveyi.","authors":["Bognar A"," Meighen E."],"journal":"Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire","year":1983,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6603890","id":"6603890","citationCount":0,"stringAuthors":"Bognar A,  Meighen E."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/6603890","resource":"6603890","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH3A2","resource":"ALDH3A2","type":"HGNC_SYMBOL"}]},{"name":"Flavin reductase (NADPH)","references":[{"annotatorClassName":"","article":{"title":"Characterization of two components of the 2-naphthoate monooxygenase system from Burkholderia sp. strain JT1500.","authors":["Deng D"," Li X"," Fang X"," Sun G."],"journal":"FEMS microbiology letters","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17559398","id":"17559398","citationCount":1,"stringAuthors":"Deng D,  Li X,  Fang X,  Sun G."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17559398","resource":"17559398","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=BLVRB","resource":"BLVRB","type":"HGNC_SYMBOL"}]},{"name":"GDH/6PGL endoplasmic bifunctional protein","references":[{"annotatorClassName":"","article":{"title":"Electrochemical regeneration of NADH using conductive vanadia-silica xerogels.","authors":["Siu E"," Won K"," Park CB."],"journal":"Biotechnology progress","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17269701","id":"17269701","citationCount":10,"stringAuthors":"Siu E,  Won K,  Park CB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17269701","resource":"17269701","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Co-expression of P450 BM3 and glucose dehydrogenase by recombinant Escherichia coli and its application in an NADPH-dependent indigo production system.","authors":["Lu Y"," Mei L."],"journal":"Journal of industrial microbiology & biotechnology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17171348","id":"17171348","citationCount":10,"stringAuthors":"Lu Y,  Mei L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17171348","resource":"17171348","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"In vitro RNA editing in plant mitochondria does not require added energy.","authors":["Takenaka M"," Verbitskiy D"," van der Merwe JA"," Zehrmann A"," Plessmann U"," Urlaub H"," Brennicke A."],"journal":"FEBS letters","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17531229","id":"17531229","citationCount":3,"stringAuthors":"Takenaka M,  Verbitskiy D,  van der Merwe JA,  Zehrmann A,  Plessmann U,  Urlaub H,  Brennicke A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17531229","resource":"17531229","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"[Lymphocyte metabolism in patients with acute pancreatitis with different genotypes of GSTM1 and GSTT1 genes].","authors":["Markova EV"," Zotova NV"," Savchenko AA"," Titova NM"," Slepov EV"," Cherdantsev DV"," Konovalenko AN."],"journal":"Biomeditsinskaia khimiia","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","id":"16898590","citationCount":1,"stringAuthors":"Markova EV,  Zotova NV,  Savchenko AA,  Titova NM,  Slepov EV,  Cherdantsev DV,  Konovalenko AN."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","resource":"16898590","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Coimmobilization of dehydrogenases and their cofactors in electrochemical biosensors.","authors":["Zhang M"," Mullens C"," Gorski W."],"journal":"Analytical chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17298031","id":"17298031","citationCount":18,"stringAuthors":"Zhang M,  Mullens C,  Gorski W."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17298031","resource":"17298031","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=H6PD","resource":"H6PD","type":"HGNC_SYMBOL"}]},{"name":"GDP-L-fucose synthase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=TSTA3","resource":"TSTA3","type":"HGNC_SYMBOL"}]},{"name":"Glutamate dehydrogenase 1, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GLUD1","resource":"GLUD1","type":"HGNC_SYMBOL"}]},{"name":"Glutamate dehydrogenase 2, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GLUD2","resource":"GLUD2","type":"HGNC_SYMBOL"}]},{"name":"Glutathione reductase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Evidence for an additional disulfide reduction pathway in Escherichia coli.","authors":["Knapp KG"," Swartz JR."],"journal":"Journal of bioscience and bioengineering","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17502280","id":"17502280","citationCount":3,"stringAuthors":"Knapp KG,  Swartz JR."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17502280","resource":"17502280","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status.","authors":["Aon MA"," Cortassa S"," Maack C"," O'Rourke B."],"journal":"The Journal of biological chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17540766","id":"17540766","citationCount":92,"stringAuthors":"Aon MA,  Cortassa S,  Maack C,  O'Rourke B."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17540766","resource":"17540766","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Damage of oxidative stress on mitochondria during microspores development in Honglian CMS line of rice.","authors":["Wan C"," Li S"," Wen L"," Kong J"," Wang K"," Zhu Y."],"journal":"Plant cell reports","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17053903","id":"17053903","citationCount":22,"stringAuthors":"Wan C,  Li S,  Wen L,  Kong J,  Wang K,  Zhu Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17053903","resource":"17053903","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The relationship of the redox potentials of thioredoxin and thioredoxin reductase from Drosophila melanogaster to the enzymatic mechanism: reduced thioredoxin is the reductant of glutathione in Drosophila.","authors":["Cheng Z"," Arscott LD"," Ballou DP"," Williams CH."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17550271","id":"17550271","citationCount":27,"stringAuthors":"Cheng Z,  Arscott LD,  Ballou DP,  Williams CH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17550271","resource":"17550271","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Zinc irreversibly damages major enzymes of energy production and antioxidant defense prior to mitochondrial permeability transition.","authors":["Gazaryan IG"," Krasinskaya IP"," Kristal BS"," Brown AM."],"journal":"The Journal of biological chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17565998","id":"17565998","citationCount":59,"stringAuthors":"Gazaryan IG,  Krasinskaya IP,  Kristal BS,  Brown AM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17565998","resource":"17565998","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GSR","resource":"GSR","type":"HGNC_SYMBOL"}]},{"name":"Glyceraldehyde-3-phosphate dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"[Lymphocyte metabolism in patients with acute pancreatitis with different genotypes of GSTM1 and GSTT1 genes].","authors":["Markova EV"," Zotova NV"," Savchenko AA"," Titova NM"," Slepov EV"," Cherdantsev DV"," Konovalenko AN."],"journal":"Biomeditsinskaia khimiia","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","id":"16898590","citationCount":1,"stringAuthors":"Markova EV,  Zotova NV,  Savchenko AA,  Titova NM,  Slepov EV,  Cherdantsev DV,  Konovalenko AN."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","resource":"16898590","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Pyridine nucleotide redox abnormalities in diabetes.","authors":["Ido Y."],"journal":"Antioxidants & redox signaling","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","id":"17508915","citationCount":36,"stringAuthors":"Ido Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","resource":"17508915","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Thioredoxin-dependent regulation of photosynthetic glyceraldehyde-3-phosphate dehydrogenase: autonomous vs. CP12-dependent mechanisms.","authors":["Trost P"," Fermani S"," Marri L"," Zaffagnini M"," Falini G"," Scagliarini S"," Pupillo P"," Sparla F."],"journal":"Photosynthesis research","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17031544","id":"17031544","citationCount":28,"stringAuthors":"Trost P,  Fermani S,  Marri L,  Zaffagnini M,  Falini G,  Scagliarini S,  Pupillo P,  Sparla F."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17031544","resource":"17031544","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Sevoflurane modulates the activity of glyceraldehyde 3-phosphate dehydrogenase.","authors":["Swearengin TA"," Fibuch EE"," Seidler NW."],"journal":"Journal of enzyme inhibition and medicinal chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17194030","id":"17194030","citationCount":3,"stringAuthors":"Swearengin TA,  Fibuch EE,  Seidler NW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17194030","resource":"17194030","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GAPDH","resource":"GAPDH","type":"HGNC_SYMBOL"}]},{"name":"Glyceraldehyde-3-phosphate dehydrogenase, testis-specific","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Oral streptococcal glyceraldehyde-3-phosphate dehydrogenase mediates interaction with Porphyromonas gingivalis fimbriae.","authors":["Maeda K"," Nagata H"," Nonaka A"," Kataoka K"," Tanaka M"," Shizukuishi S."],"journal":"Microbes and infection","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15488735","id":"15488735","citationCount":20,"stringAuthors":"Maeda K,  Nagata H,  Nonaka A,  Kataoka K,  Tanaka M,  Shizukuishi S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15488735","resource":"15488735","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Characterization of native and recombinant A4 glyceraldehyde 3-phosphate dehydrogenase. Kinetic evidence for confromation changes upon association with the small protein CP12.","authors":["Graciet E"," Lebreton S"," Camadro JM"," Gontero B."],"journal":"European journal of biochemistry","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12492483","id":"12492483","citationCount":26,"stringAuthors":"Graciet E,  Lebreton S,  Camadro JM,  Gontero B."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12492483","resource":"12492483","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase.","authors":["Ismail SA"," Park HW."],"journal":"Acta crystallographica. Section D, Biological crystallography","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16239728","id":"16239728","citationCount":16,"stringAuthors":"Ismail SA,  Park HW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16239728","resource":"16239728","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GAPDHS","resource":"GAPDHS","type":"HGNC_SYMBOL"}]},{"name":"Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic","references":[{"annotatorClassName":"","article":{"title":"New competitive inhibitors of cytosolic (NADH-dependent) rabbit muscle glycerophosphate dehydrogenase.","authors":["Fonvielle M"," Therisod H"," Hemery M"," Therisod M."],"journal":"Bioorganic & medicinal chemistry letters","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17088060","id":"17088060","citationCount":0,"stringAuthors":"Fonvielle M,  Therisod H,  Hemery M,  Therisod M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17088060","resource":"17088060","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GPD1","resource":"GPD1","type":"HGNC_SYMBOL"}]},{"name":"Heme oxygenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Oxidative stress-related factors in Bartter's and Gitelman's syndromes: relevance for angiotensin II signalling.","authors":["Calò LA"," Pagnin E"," Davis PA"," Sartori M"," Semplicini A."],"journal":"Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12897089","id":"12897089","citationCount":26,"stringAuthors":"Calò LA,  Pagnin E,  Davis PA,  Sartori M,  Semplicini A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12897089","resource":"12897089","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae.","authors":["Auclair K"," Huang HW"," Moënne-Loccoz P"," Ortiz de Montellano PR."],"journal":"Protein expression and purification","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12699699","id":"12699699","citationCount":3,"stringAuthors":"Auclair K,  Huang HW,  Moënne-Loccoz P,  Ortiz de Montellano PR."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12699699","resource":"12699699","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HMOX1","resource":"HMOX1","type":"HGNC_SYMBOL"}]},{"name":"Heme oxygenase 2","references":[{"annotatorClassName":"","article":{"title":"DNA cleavage by UVA irradiation of NADH with dioxygen via radical chain processes.","authors":["Tanaka M"," Ohkubo K"," Fukuzumi S."],"journal":"The journal of physical chemistry. A","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16986858","id":"16986858","citationCount":20,"stringAuthors":"Tanaka M,  Ohkubo K,  Fukuzumi S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16986858","resource":"16986858","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inactivation of copper, zinc superoxide dismutase by H2O2 : mechanism of protection.","authors":["Goldstone AB"," Liochev SI"," Fridovich I."],"journal":"Free radical biology & medicine","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17157188","id":"17157188","citationCount":7,"stringAuthors":"Goldstone AB,  Liochev SI,  Fridovich I."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17157188","resource":"17157188","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HMOX2","resource":"HMOX2","type":"HGNC_SYMBOL"}]},{"name":"Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neurons.","authors":["Norman JP"," Perry SW"," Kasischke KA"," Volsky DJ"," Gelbard HA."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17202348","id":"17202348","citationCount":27,"stringAuthors":"Norman JP,  Perry SW,  Kasischke KA,  Volsky DJ,  Gelbard HA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17202348","resource":"17202348","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HADH","resource":"HADH","type":"HGNC_SYMBOL"}]},{"name":"Inosine-5'-monophosphate dehydrogenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Spectrum and frequency of mutations in IMPDH1 associated with autosomal dominant retinitis pigmentosa and leber congenital amaurosis.","authors":["Bowne SJ"," Sullivan LS"," Mortimer SE"," Hedstrom L"," Zhu J"," Spellicy CJ"," Gire AI"," Hughbanks-Wheaton D"," Birch DG"," Lewis RA"," Heckenlively JR"," Daiger SP."],"journal":"Investigative ophthalmology & visual science","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16384941","id":"16384941","citationCount":69,"stringAuthors":"Bowne SJ,  Sullivan LS,  Mortimer SE,  Hedstrom L,  Zhu J,  Spellicy CJ,  Gire AI,  Hughbanks-Wheaton D,  Birch DG,  Lewis RA,  Heckenlively JR,  Daiger SP."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16384941","resource":"16384941","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IMPDH1","resource":"IMPDH1","type":"HGNC_SYMBOL"}]},{"name":"Inosine-5'-monophosphate dehydrogenase 2","references":[{"annotatorClassName":"","article":{"title":"A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity.","authors":["Wang J"," Zeevi A"," Webber S"," Girnita DM"," Addonizio L"," Selby R"," Hutchinson IV"," Burckart GJ."],"journal":"Pharmacogenetics and genomics","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17496727","id":"17496727","citationCount":31,"stringAuthors":"Wang J,  Zeevi A,  Webber S,  Girnita DM,  Addonizio L,  Selby R,  Hutchinson IV,  Burckart GJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17496727","resource":"17496727","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IMPDH2","resource":"IMPDH2","type":"HGNC_SYMBOL"}]},{"name":"Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diphosphopyridine nucleotide isocitric dehydrogenase from animal tissues.","authors":["PLAUT GW"," SUNG SC."],"journal":"The Journal of biological chemistry","year":1954,"link":"http://www.ncbi.nlm.nih.gov/pubmed/13152105","id":"13152105","citationCount":36,"stringAuthors":"PLAUT GW,  SUNG SC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/13152105","resource":"13152105","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diphosphopyridine nucleotide specific isocitric dehydrogenase of mammalian mitochondria. I. On the roles of pyridine nucleotide transhydrogenase and the isocitric dehydrogenases in the respiration of mitochondria of normal and neoplastic tissues.","authors":["Stein AM"," Stein JH"," Kirkman SK."],"journal":"Biochemistry","year":1967,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","id":"4292141","citationCount":17,"stringAuthors":"Stein AM,  Stein JH,  Kirkman SK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","resource":"4292141","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The stereochemistry of the nicotinamide adenine dinucleotide-specific isocitric dehydrogenase reaction.","authors":["Rose ZB."],"journal":"The Journal of biological chemistry","year":1966,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","id":"4380379","citationCount":1,"stringAuthors":"Rose ZB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","resource":"4380379","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IDH3A","resource":"IDH3A","type":"HGNC_SYMBOL"}]},{"name":"Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diphosphopyridine nucleotide specific isocitric dehydrogenase of mammalian mitochondria. I. On the roles of pyridine nucleotide transhydrogenase and the isocitric dehydrogenases in the respiration of mitochondria of normal and neoplastic tissues.","authors":["Stein AM"," Stein JH"," Kirkman SK."],"journal":"Biochemistry","year":1967,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","id":"4292141","citationCount":17,"stringAuthors":"Stein AM,  Stein JH,  Kirkman SK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","resource":"4292141","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NICOTINAMIDE ADENINE DINUCLEOTIDE-SPECIFIC ISOCITRIC DEHYDROGENASE. A POSSIBLE REGULATORY PROTEIN.","authors":["SANWAL BD"," ZINK MW"," STACHOW CS."],"journal":"The Journal of biological chemistry","year":1964,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14189899","id":"14189899","citationCount":25,"stringAuthors":"SANWAL BD,  ZINK MW,  STACHOW CS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14189899","resource":"14189899","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The stereochemistry of the nicotinamide adenine dinucleotide-specific isocitric dehydrogenase reaction.","authors":["Rose ZB."],"journal":"The Journal of biological chemistry","year":1966,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","id":"4380379","citationCount":1,"stringAuthors":"Rose ZB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","resource":"4380379","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IDH3B","resource":"IDH3B","type":"HGNC_SYMBOL"}]},{"name":"Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diphosphopyridine nucleotide specific isocitric dehydrogenase of mammalian mitochondria. I. On the roles of pyridine nucleotide transhydrogenase and the isocitric dehydrogenases in the respiration of mitochondria of normal and neoplastic tissues.","authors":["Stein AM"," Stein JH"," Kirkman SK."],"journal":"Biochemistry","year":1967,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","id":"4292141","citationCount":17,"stringAuthors":"Stein AM,  Stein JH,  Kirkman SK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4292141","resource":"4292141","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NICOTINAMIDE ADENINE DINUCLEOTIDE-SPECIFIC ISOCITRIC DEHYDROGENASE. A POSSIBLE REGULATORY PROTEIN.","authors":["SANWAL BD"," ZINK MW"," STACHOW CS."],"journal":"The Journal of biological chemistry","year":1964,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14189899","id":"14189899","citationCount":25,"stringAuthors":"SANWAL BD,  ZINK MW,  STACHOW CS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14189899","resource":"14189899","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The stereochemistry of the nicotinamide adenine dinucleotide-specific isocitric dehydrogenase reaction.","authors":["Rose ZB."],"journal":"The Journal of biological chemistry","year":1966,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","id":"4380379","citationCount":1,"stringAuthors":"Rose ZB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4380379","resource":"4380379","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IDH3G","resource":"IDH3G","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase A chain","references":[{"annotatorClassName":"","article":{"title":"Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1.","authors":["Semenza GL."],"journal":"The Biochemical journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17555402","id":"17555402","citationCount":217,"stringAuthors":"Semenza GL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17555402","resource":"17555402","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Histochemical and histopathological study of the gastric mucosa in the portal hypertensive gastropathy.","authors":["Drăghia AC."],"journal":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17308685","id":"17308685","citationCount":3,"stringAuthors":"Drăghia AC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17308685","resource":"17308685","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Kinetic parameters and lactate dehydrogenase isozyme activities support possible lactate utilization by neurons.","authors":["O'Brien J"," Kla KM"," Hopkins IB"," Malecki EA"," McKenna MC."],"journal":"Neurochemical research","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17006762","id":"17006762","citationCount":30,"stringAuthors":"O'Brien J,  Kla KM,  Hopkins IB,  Malecki EA,  McKenna MC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17006762","resource":"17006762","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHA","resource":"LDHA","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase A-like 6A","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHAL6A","resource":"LDHAL6A","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase A-like 6B","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHAL6B","resource":"LDHAL6B","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase B chain","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Domain closure, substrate specificity and catalysis of D-lactate dehydrogenase from Lactobacillus bulgaricus.","authors":["Razeto A"," Kochhar S"," Hottinger H"," Dauter M"," Wilson KS"," Lamzin VS."],"journal":"Journal of molecular biology","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12054772","id":"12054772","citationCount":33,"stringAuthors":"Razeto A,  Kochhar S,  Hottinger H,  Dauter M,  Wilson KS,  Lamzin VS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12054772","resource":"12054772","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A preliminary account of the properties of recombinant human Glyoxylate reductase (GRHPR), LDHA and LDHB with glyoxylate, and their potential roles in its metabolism.","authors":["Mdluli K"," Booth MP"," Brady RL"," Rumsby G."],"journal":"Biochimica et biophysica acta","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16198644","id":"16198644","citationCount":16,"stringAuthors":"Mdluli K,  Booth MP,  Brady RL,  Rumsby G."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16198644","resource":"16198644","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Lactate dehydrogenase isoenzymes of sperm cells and tests.","authors":["Clausen J."],"journal":"The Biochemical journal","year":1969,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4303363","id":"4303363","citationCount":11,"stringAuthors":"Clausen J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/4303363","resource":"4303363","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHB","resource":"LDHB","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase C chain","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Rapid purification of lactate dehydrogenase X from mouse testes by two steps of affinity chromatography on oxamate-sepharose.","authors":["Spielmann H"," Eibs HG"," Mentzel C."],"journal":"Experientia","year":1976,"link":"http://www.ncbi.nlm.nih.gov/pubmed/182529","id":"182529","citationCount":1,"stringAuthors":"Spielmann H,  Eibs HG,  Mentzel C."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/182529","resource":"182529","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of testicular LDH-X from laboratory animals and man by gossypol and its isomers.","authors":["Morris ID"," Higgins C"," Matlin SA."],"journal":"Journal of reproduction and fertility","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3735252","id":"3735252","citationCount":3,"stringAuthors":"Morris ID,  Higgins C,  Matlin SA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3735252","resource":"3735252","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Developmental changes in lactate dehydrogenase-X activity in young jaundiced male rats.","authors":["Gu Y"," Davis DR"," Lin YC."],"journal":"Archives of andrology","year":1989,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2751392","id":"2751392","citationCount":10,"stringAuthors":"Gu Y,  Davis DR,  Lin YC."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/2751392","resource":"2751392","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHC","resource":"LDHC","type":"HGNC_SYMBOL"}]},{"name":"Malate dehydrogenase, cytoplasmic","references":[{"annotatorClassName":"","article":{"title":"Heterologous expression of cDNAs encoding monodehydroascorbate reductases from the moss, Physcomitrella patens and characterization of the expressed enzymes.","authors":["Drew DP"," Lunde C"," Lahnstein J"," Fincher GB."],"journal":"Planta","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16983536","id":"16983536","citationCount":7,"stringAuthors":"Drew DP,  Lunde C,  Lahnstein J,  Fincher GB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16983536","resource":"16983536","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MDH1","resource":"MDH1","type":"HGNC_SYMBOL"}]},{"name":"Malate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"D-mannitol production by resting state whole cell biotrans-formation of D-fructose by heterologous mannitol and formate dehydrogenase gene expression in Bacillus megaterium.","authors":["Bäumchen C"," Roth AH"," Biedendieck R"," Malten M"," Follmann M"," Sahm H"," Bringer-Meyer S"," Jahn D."],"journal":"Biotechnology journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17619232","id":"17619232","citationCount":11,"stringAuthors":"Bäumchen C,  Roth AH,  Biedendieck R,  Malten M,  Follmann M,  Sahm H,  Bringer-Meyer S,  Jahn D."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17619232","resource":"17619232","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Fluorescent sensing layer for the determination of L-malic acid in wine.","authors":["Gallarta F"," Sáinz FJ"," Sáenz C."],"journal":"Analytical and bioanalytical chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17203264","id":"17203264","citationCount":2,"stringAuthors":"Gallarta F,  Sáinz FJ,  Sáenz C."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17203264","resource":"17203264","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"[Lymphocyte metabolism in patients with acute pancreatitis with different genotypes of GSTM1 and GSTT1 genes].","authors":["Markova EV"," Zotova NV"," Savchenko AA"," Titova NM"," Slepov EV"," Cherdantsev DV"," Konovalenko AN."],"journal":"Biomeditsinskaia khimiia","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","id":"16898590","citationCount":1,"stringAuthors":"Markova EV,  Zotova NV,  Savchenko AA,  Titova NM,  Slepov EV,  Cherdantsev DV,  Konovalenko AN."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898590","resource":"16898590","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Characterization of malate dehydrogenase from the hyperthermophilic archaeon Pyrobaculum islandicum.","authors":["Yennaco LJ"," Hu Y"," Holden JF."],"journal":"Extremophiles : life under extreme conditions","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17487443","id":"17487443","citationCount":5,"stringAuthors":"Yennaco LJ,  Hu Y,  Holden JF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17487443","resource":"17487443","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"L-2-hydroxyglutaric aciduria, a defect of metabolite repair.","authors":["Rzem R"," Vincent MF"," Van Schaftingen E"," Veiga-da-Cunha M."],"journal":"Journal of inherited metabolic disease","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17603759","id":"17603759","citationCount":52,"stringAuthors":"Rzem R,  Vincent MF,  Van Schaftingen E,  Veiga-da-Cunha M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17603759","resource":"17603759","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MDH2","resource":"MDH2","type":"HGNC_SYMBOL"}]},{"name":"Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The effect of ligand binding on the proteolytic pattern of methylmalonate semialdehyde dehydrogenase.","authors":["Kedishvili NY"," Popov KM"," Harris RA."],"journal":"Archives of biochemistry and biophysics","year":1991,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1898092","id":"1898092","citationCount":1,"stringAuthors":"Kedishvili NY,  Popov KM,  Harris RA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1898092","resource":"1898092","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH6A1","resource":"ALDH6A1","type":"HGNC_SYMBOL"}]},{"name":"Methylsterol monooxygenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MSMO1","resource":"MSMO1","type":"HGNC_SYMBOL"}]},{"name":"NAD(P) transhydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Expression of the Escherichia coli pntAB genes encoding a membrane-bound transhydrogenase in Corynebacterium glutamicum improves L-lysine formation.","authors":["Kabus A"," Georgi T"," Wendisch VF"," Bott M."],"journal":"Applied microbiology and biotechnology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17216441","id":"17216441","citationCount":49,"stringAuthors":"Kabus A,  Georgi T,  Wendisch VF,  Bott M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17216441","resource":"17216441","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NNT","resource":"NNT","type":"HGNC_SYMBOL"}]},{"name":"NAD-dependent malic enzyme, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ME2","resource":"ME2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The NDUFA1 gene product (MWFE protein) is essential for activity of complex I in mammalian mitochondria.","authors":["Au HC"," Seo BB"," Matsuno-Yagi A"," Yagi T"," Scheffler IE."],"journal":"Proceedings of the National Academy of Sciences of the United States of America","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10200266","id":"10200266","citationCount":28,"stringAuthors":"Au HC,  Seo BB,  Matsuno-Yagi A,  Yagi T,  Scheffler IE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10200266","resource":"10200266","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase.","authors":["Raha S"," Myint AT"," Johnstone L"," Robinson BH."],"journal":"Free radical biology & medicine","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","id":"11864782","citationCount":45,"stringAuthors":"Raha S,  Myint AT,  Johnstone L,  Robinson BH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","resource":"11864782","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA1","resource":"NDUFA1","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA10","resource":"NDUFA10","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA11","resource":"NDUFA11","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA12","resource":"NDUFA12","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA13","resource":"NDUFA13","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA2","resource":"NDUFA2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA3","resource":"NDUFA3","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA4","resource":"NDUFA4","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA4L2","resource":"NDUFA4L2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5","references":[{"annotatorClassName":"","article":{"title":"Site-specific S-glutathiolation of mitochondrial NADH ubiquinone reductase.","authors":["Chen CL"," Zhang L"," Yeh A"," Chen CA"," Green-Church KB"," Zweier JL"," Chen YR."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17444656","id":"17444656","citationCount":42,"stringAuthors":"Chen CL,  Zhang L,  Yeh A,  Chen CA,  Green-Church KB,  Zweier JL,  Chen YR."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17444656","resource":"17444656","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Role of the conserved arginine 274 and histidine 224 and 228 residues in the NuoCD subunit of complex I from Escherichia coli.","authors":["Belevich G"," Euro L"," Wikström M"," Verkhovskaya M."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17209562","id":"17209562","citationCount":15,"stringAuthors":"Belevich G,  Euro L,  Wikström M,  Verkhovskaya M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17209562","resource":"17209562","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA5","resource":"NDUFA5","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA6","resource":"NDUFA6","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA7","resource":"NDUFA7","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The nuclear-encoded human NADH:ubiquinone oxidoreductase NDUFA8 subunit: cDNA cloning, chromosomal localization, tissue distribution, and mutation detection in complex-I-deficient patients.","authors":["Triepels R"," van den Heuvel L"," Loeffen J"," Smeets R"," Trijbels F"," Smeitink J."],"journal":"Human genetics","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9860297","id":"9860297","citationCount":5,"stringAuthors":"Triepels R,  van den Heuvel L,  Loeffen J,  Smeets R,  Trijbels F,  Smeitink J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9860297","resource":"9860297","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA8","resource":"NDUFA8","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"The flavoprotein subcomplex of complex I (NADH:ubiquinone oxidoreductase) from bovine heart mitochondria: insights into the mechanisms of NADH oxidation and NAD+ reduction from protein film voltammetry.","authors":["Barker CD"," Reda T"," Hirst J."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17323923","id":"17323923","citationCount":14,"stringAuthors":"Barker CD,  Reda T,  Hirst J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17323923","resource":"17323923","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Maintenance of the metabolic homeostasis of the heart: developing a systems analysis approach.","authors":["Balaban RS."],"journal":"Annals of the New York Academy of Sciences","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17132781","id":"17132781","citationCount":15,"stringAuthors":"Balaban RS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17132781","resource":"17132781","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of complex I by Ca2+ reduces electron transport activity and the rate of superoxide anion production in cardiac submitochondrial particles.","authors":["Matsuzaki S"," Szweda LI."],"journal":"Biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17260964","id":"17260964","citationCount":11,"stringAuthors":"Matsuzaki S,  Szweda LI."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17260964","resource":"17260964","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle.","authors":["Fisher N"," Bray PG"," Ward SA"," Biagini GA."],"journal":"Trends in parasitology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17499024","id":"17499024","citationCount":32,"stringAuthors":"Fisher N,  Bray PG,  Ward SA,  Biagini GA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17499024","resource":"17499024","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cloning and sequence analysis of the gene encoding 19-kD subunit of Complex I from Dunaliella salina.","authors":["Liu Y"," Qiao DR"," Zheng HB"," Dai XL"," Bai LH"," Zeng J"," Cao Y."],"journal":"Molecular biology reports","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17530440","id":"17530440","citationCount":3,"stringAuthors":"Liu Y,  Qiao DR,  Zheng HB,  Dai XL,  Bai LH,  Zeng J,  Cao Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17530440","resource":"17530440","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA9","resource":"NDUFA9","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB1","resource":"NDUFB1","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB10","resource":"NDUFB10","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB2","resource":"NDUFB2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB3","resource":"NDUFB3","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB4","resource":"NDUFB4","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB5","resource":"NDUFB5","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB6","resource":"NDUFB6","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase.","authors":["Raha S"," Myint AT"," Johnstone L"," Robinson BH."],"journal":"Free radical biology & medicine","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","id":"11864782","citationCount":45,"stringAuthors":"Raha S,  Myint AT,  Johnstone L,  Robinson BH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","resource":"11864782","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB7","resource":"NDUFB7","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB8","resource":"NDUFB8","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB9","resource":"NDUFB9","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFC1","resource":"NDUFC1","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 subunit C2","references":[{"annotatorClassName":"","article":{"title":"Regulatory loop between redox sensing of the NADH/NAD(+) ratio by Rex (YdiH) and oxidation of NADH by NADH dehydrogenase Ndh in Bacillus subtilis.","authors":["Gyan S"," Shiohira Y"," Sato I"," Takeuchi M"," Sato T."],"journal":"Journal of bacteriology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17015645","id":"17015645","citationCount":59,"stringAuthors":"Gyan S,  Shiohira Y,  Sato I,  Takeuchi M,  Sato T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17015645","resource":"17015645","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stimulation of chlororespiration by heat and high light intensity in oat plants.","authors":["Quiles MJ."],"journal":"Plant, cell & environment","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898010","id":"16898010","citationCount":36,"stringAuthors":"Quiles MJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16898010","resource":"16898010","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Generation of a membrane potential by Lactococcus lactis through aerobic electron transport.","authors":["Brooijmans RJ"," Poolman B"," Schuurman-Wolters GK"," de Vos WM"," Hugenholtz J."],"journal":"Journal of bacteriology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17496098","id":"17496098","citationCount":31,"stringAuthors":"Brooijmans RJ,  Poolman B,  Schuurman-Wolters GK,  de Vos WM,  Hugenholtz J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17496098","resource":"17496098","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Association of MT-ND5 gene variation with mitochondrial respiratory control ratio and NADH dehydrogenase activity in Tibet chicken embryos.","authors":["Bao HG"," Zhao CJ"," Li JY"," Wu Ch."],"journal":"Animal genetics","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17614984","id":"17614984","citationCount":3,"stringAuthors":"Bao HG,  Zhao CJ,  Li JY,  Wu Ch."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17614984","resource":"17614984","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Ischemic preconditioning prevents in vivo hyperoxygenation in postischemic myocardium with preservation of mitochondrial oxygen consumption.","authors":["Zhu X"," Liu B"," Zhou S"," Chen YR"," Deng Y"," Zweier JL"," He G."],"journal":"American journal of physiology. Heart and circulatory physiology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17513495","id":"17513495","citationCount":19,"stringAuthors":"Zhu X,  Liu B,  Zhou S,  Chen YR,  Deng Y,  Zweier JL,  He G."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17513495","resource":"17513495","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFC2","resource":"NDUFC2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cloning of the human mitochondrial 51 kDa subunit (NDUFV1) reveals a 100% antisense homology of its 3'UTR with the 5'UTR of the gamma-interferon inducible protein (IP-30) precursor: is this a link between mitochondrial myopathy and inflammation?","authors":["Schuelke M"," Loeffen J"," Mariman E"," Smeitink J"," van den Heuvel L."],"journal":"Biochemical and biophysical research communications","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9571201","id":"9571201","citationCount":8,"stringAuthors":"Schuelke M,  Loeffen J,  Mariman E,  Smeitink J,  van den Heuvel L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9571201","resource":"9571201","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Chromosomal localization of the human gene encoding the 51-kDa subunit of mitochondrial complex I (NDUFV1) to 11q13.","authors":["Ali ST"," Duncan AM"," Schappert K"," Heng HH"," Tsui LC"," Chow W"," Robinson BH."],"journal":"Genomics","year":1993,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8288251","id":"8288251","citationCount":13,"stringAuthors":"Ali ST,  Duncan AM,  Schappert K,  Heng HH,  Tsui LC,  Chow W,  Robinson BH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8288251","resource":"8288251","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis.","authors":["Grad LI"," Lemire BD."],"journal":"Human molecular genetics","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14662656","id":"14662656","citationCount":52,"stringAuthors":"Grad LI,  Lemire BD."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/14662656","resource":"14662656","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFV1","resource":"NDUFV1","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Identification of genes regulated by UV/salicylic acid.","authors":["Paunesku T"," Chang-Liu CM"," Shearin-Jones P"," Watson C"," Milton J"," Oryhon J"," Salbego D"," Milosavljevic A"," Woloschak GE."],"journal":"International journal of radiation biology","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10716640","id":"10716640","citationCount":2,"stringAuthors":"Paunesku T,  Chang-Liu CM,  Shearin-Jones P,  Watson C,  Milton J,  Oryhon J,  Salbego D,  Milosavljevic A,  Woloschak GE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10716640","resource":"10716640","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFV2","resource":"NDUFV2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFV3","resource":"NDUFV3","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS2","resource":"NDUFS2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS3","resource":"NDUFS3","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The NADH: ubiquinone oxidoreductase (complex I) of the mammalian respiratory chain and the cAMP cascade.","authors":["Papa S"," Sardanelli AM"," Scacco S"," Petruzzella V"," Technikova-Dobrova Z"," Vergari R"," Signorile A."],"journal":"Journal of bioenergetics and biomembranes","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11860175","id":"11860175","citationCount":23,"stringAuthors":"Papa S,  Sardanelli AM,  Scacco S,  Petruzzella V,  Technikova-Dobrova Z,  Vergari R,  Signorile A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11860175","resource":"11860175","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A nonsense mutation in the NDUFS4 gene encoding the 18 kDa (AQDQ) subunit of complex I abolishes assembly and activity of the complex in a patient with Leigh-like syndrome.","authors":["Petruzzella V"," Vergari R"," Puzziferri I"," Boffoli D"," Lamantea E"," Zeviani M"," Papa S."],"journal":"Human molecular genetics","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11181577","id":"11181577","citationCount":54,"stringAuthors":"Petruzzella V,  Vergari R,  Puzziferri I,  Boffoli D,  Lamantea E,  Zeviani M,  Papa S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11181577","resource":"11181577","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase.","authors":["Raha S"," Myint AT"," Johnstone L"," Robinson BH."],"journal":"Free radical biology & medicine","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","id":"11864782","citationCount":45,"stringAuthors":"Raha S,  Myint AT,  Johnstone L,  Robinson BH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11864782","resource":"11864782","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS4","resource":"NDUFS4","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 5","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The human NADH: ubiquinone oxidoreductase NDUFS5 (15 kDa) subunit: cDNA cloning, chromosomal localization, tissue distribution and the absence of mutations in isolated complex I-deficient patients.","authors":["Loeffen J"," Smeets R"," Smeitink J"," Triepels R"," Sengers R"," Trijbels F"," van den Heuvel L."],"journal":"Journal of inherited metabolic disease","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10070614","id":"10070614","citationCount":3,"stringAuthors":"Loeffen J,  Smeets R,  Smeitink J,  Triepels R,  Sengers R,  Trijbels F,  van den Heuvel L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10070614","resource":"10070614","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS5","resource":"NDUFS5","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS6","resource":"NDUFS6","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone.","authors":["Schuler F"," Yano T"," Di Bernardo S"," Yagi T"," Yankovskaya V"," Singer TP"," Casida JE."],"journal":"Proceedings of the National Academy of Sciences of the United States of America","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10097178","id":"10097178","citationCount":51,"stringAuthors":"Schuler F,  Yano T,  Di Bernardo S,  Yagi T,  Yankovskaya V,  Singer TP,  Casida JE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10097178","resource":"10097178","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Assignment of the PSST subunit gene of human mitochondrial complex I to chromosome 19p13.","authors":["Hyslop SJ"," Duncan AM"," Pitkänen S"," Robinson BH."],"journal":"Genomics","year":1996,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8938450","id":"8938450","citationCount":8,"stringAuthors":"Hyslop SJ,  Duncan AM,  Pitkänen S,  Robinson BH."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8938450","resource":"8938450","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Intimate relationships of the large and the small subunits of all nickel hydrogenases with two nuclear-encoded subunits of mitochondrial NADH: ubiquinone oxidoreductase.","authors":["Albracht SP."],"journal":"Biochimica et biophysica acta","year":1993,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8369340","id":"8369340","citationCount":22,"stringAuthors":"Albracht SP."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8369340","resource":"8369340","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS7","resource":"NDUFS7","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Learning from hydrogenases: location of a proton pump and of a second FMN in bovine NADH--ubiquinone oxidoreductase (Complex I).","authors":["Albracht SP"," Hedderich R."],"journal":"FEBS letters","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11086155","id":"11086155","citationCount":29,"stringAuthors":"Albracht SP,  Hedderich R."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11086155","resource":"11086155","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The first nuclear-encoded complex I mutation in a patient with Leigh syndrome.","authors":["Loeffen J"," Smeitink J"," Triepels R"," Smeets R"," Schuelke M"," Sengers R"," Trijbels F"," Hamel B"," Mullaart R"," van den Heuvel L."],"journal":"American journal of human genetics","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9837812","id":"9837812","citationCount":101,"stringAuthors":"Loeffen J,  Smeitink J,  Triepels R,  Smeets R,  Schuelke M,  Sengers R,  Trijbels F,  Hamel B,  Mullaart R,  van den Heuvel L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9837812","resource":"9837812","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Association of ferredoxin-NADP oxidoreductase with the chloroplastic pyridine nucleotide dehydrogenase complex in barley leaves","authors":["Jose Quiles M"," Cuello J."],"journal":"Plant physiology","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9576793","id":"9576793","citationCount":23,"stringAuthors":"Jose Quiles M,  Cuello J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9576793","resource":"9576793","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS8","resource":"NDUFS8","type":"HGNC_SYMBOL"}]},{"name":"NADH-cytochrome b5 reductase 3","references":[{"annotatorClassName":"","article":{"title":"Expression and characterization of a functional canine variant of cytochrome b5 reductase.","authors":["Roma GW"," Crowley LJ"," Barber MJ."],"journal":"Archives of biochemistry and biophysics","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16814740","id":"16814740","citationCount":5,"stringAuthors":"Roma GW,  Crowley LJ,  Barber MJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16814740","resource":"16814740","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A novel mutation of the cytochrome-b5 reductase gene in an Indian patient: the molecular basis of type I methemoglobinemia.","authors":["Nussenzveig RH"," Lingam HB"," Gaikwad A"," Zhu Q"," Jing N"," Prchal JT."],"journal":"Haematologica","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17082011","id":"17082011","citationCount":9,"stringAuthors":"Nussenzveig RH,  Lingam HB,  Gaikwad A,  Zhu Q,  Jing N,  Prchal JT."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17082011","resource":"17082011","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Structure of Physarum polycephalum cytochrome b5 reductase at 1.56 A resolution.","authors":["Kim S"," Suga M"," Ogasahara K"," Ikegami T"," Minami Y"," Yubisui T"," Tsukihara T."],"journal":"Acta crystallographica. Section F, Structural biology and crystallization communications","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17401193","id":"17401193","citationCount":3,"stringAuthors":"Kim S,  Suga M,  Ogasahara K,  Ikegami T,  Minami Y,  Yubisui T,  Tsukihara T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17401193","resource":"17401193","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Reductive detoxification of arylhydroxylamine carcinogens by human NADH cytochrome b5 reductase and cytochrome b5.","authors":["Kurian JR"," Chin NA"," Longlais BJ"," Hayes KL"," Trepanier LA."],"journal":"Chemical research in toxicology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17040106","id":"17040106","citationCount":14,"stringAuthors":"Kurian JR,  Chin NA,  Longlais BJ,  Hayes KL,  Trepanier LA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17040106","resource":"17040106","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Structure and properties of the recombinant NADH-cytochrome b5 reductase of Physarum polycephalum.","authors":["Ikegami T"," Kameyama E"," Yamamoto SY"," Minami Y"," Yubisui T."],"journal":"Bioscience, biotechnology, and biochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17341833","id":"17341833","citationCount":1,"stringAuthors":"Ikegami T,  Kameyama E,  Yamamoto SY,  Minami Y,  Yubisui T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17341833","resource":"17341833","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=CYB5R3","resource":"CYB5R3","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS1","resource":"NDUFS1","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"TTD: Therapeutic Target Database.","authors":["Chen X"," Ji ZL"," Chen YZ."],"journal":"Nucleic acids research","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","id":"11752352","citationCount":104,"stringAuthors":"Chen X,  Ji ZL,  Chen YZ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","resource":"11752352","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND1","resource":"MT-ND1","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Differences in activity of cytochrome C oxidase in brain between sleep and wakefulness.","authors":["Nikonova EV"," Vijayasarathy C"," Zhang L"," Cater JR"," Galante RJ"," Ward SE"," Avadhani NG"," Pack AI."],"journal":"Sleep","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15700717","id":"15700717","citationCount":14,"stringAuthors":"Nikonova EV,  Vijayasarathy C,  Zhang L,  Cater JR,  Galante RJ,  Ward SE,  Avadhani NG,  Pack AI."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15700717","resource":"15700717","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"[The changes of gene expression in multiple myeloma treated with thalidomide].","authors":["Zhang HB"," Chen SL"," Liu JZ"," Xiao B"," Chen ZB"," Wang HJ."],"journal":"Zhonghua nei ke za zhi","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12882707","id":"12882707","citationCount":0,"stringAuthors":"Zhang HB,  Chen SL,  Liu JZ,  Xiao B,  Chen ZB,  Wang HJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12882707","resource":"12882707","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"TTD: Therapeutic Target Database.","authors":["Chen X"," Ji ZL"," Chen YZ."],"journal":"Nucleic acids research","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","id":"11752352","citationCount":104,"stringAuthors":"Chen X,  Ji ZL,  Chen YZ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","resource":"11752352","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND2","resource":"MT-ND2","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"TTD: Therapeutic Target Database.","authors":["Chen X"," Ji ZL"," Chen YZ."],"journal":"Nucleic acids research","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","id":"11752352","citationCount":104,"stringAuthors":"Chen X,  Ji ZL,  Chen YZ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","resource":"11752352","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND3","resource":"MT-ND3","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells.","authors":["Shen XY"," Zacal N"," Singh G"," Rainbow AJ."],"journal":"Photochemistry and photobiology","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15560738","id":"15560738","citationCount":16,"stringAuthors":"Shen XY,  Zacal N,  Singh G,  Rainbow AJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15560738","resource":"15560738","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Oxidative stress induces differential gene expression in a human lens epithelial cell line.","authors":["Carper DA"," Sun JK"," Iwata T"," Zigler JS"," Ibaraki N"," Lin LR"," Reddy V."],"journal":"Investigative ophthalmology & visual science","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9950599","id":"9950599","citationCount":21,"stringAuthors":"Carper DA,  Sun JK,  Iwata T,  Zigler JS,  Ibaraki N,  Lin LR,  Reddy V."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9950599","resource":"9950599","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Deletion of the structural gene for the NADH-dehydrogenase subunit 4 of Synechocystis 6803 alters respiratory properties.","authors":["Dzelzkalns VA"," Obinger C"," Regelsberger G"," Niederhauser H"," Kamensek M"," Peschek GA"," Bogorad L."],"journal":"Plant physiology","year":1994,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7846157","id":"7846157","citationCount":7,"stringAuthors":"Dzelzkalns VA,  Obinger C,  Regelsberger G,  Niederhauser H,  Kamensek M,  Peschek GA,  Bogorad L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7846157","resource":"7846157","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND4","resource":"MT-ND4","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 4L","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND4L","resource":"MT-ND4L","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 5","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Phylogenetic reconstruction of the Felidae using 16S rRNA and NADH-5 mitochondrial genes.","authors":["Johnson WE"," O'Brien SJ."],"journal":"Journal of molecular evolution","year":1997,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9071018","id":"9071018","citationCount":41,"stringAuthors":"Johnson WE,  O'Brien SJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9071018","resource":"9071018","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Association of MT-ND5 gene variation with mitochondrial respiratory control ratio and NADH dehydrogenase activity in Tibet chicken embryos.","authors":["Bao HG"," Zhao CJ"," Li JY"," Wu Ch."],"journal":"Animal genetics","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17614984","id":"17614984","citationCount":3,"stringAuthors":"Bao HG,  Zhao CJ,  Li JY,  Wu Ch."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17614984","resource":"17614984","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND5","resource":"MT-ND5","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 6","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND6","resource":"MT-ND6","type":"HGNC_SYMBOL"}]},{"name":"NADP-dependent malic enzyme","references":[{"annotatorClassName":"","article":{"title":"Determining Actinobacillus succinogenes metabolic pathways and fluxes by NMR and GC-MS analyses of 13C-labeled metabolic product isotopomers.","authors":["McKinlay JB"," Shachar-Hill Y"," Zeikus JG"," Vieille C."],"journal":"Metabolic engineering","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17197218","id":"17197218","citationCount":52,"stringAuthors":"McKinlay JB,  Shachar-Hill Y,  Zeikus JG,  Vieille C."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17197218","resource":"17197218","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ME1","resource":"ME1","type":"HGNC_SYMBOL"}]},{"name":"NADP-dependent malic enzyme, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates.","authors":["Luo C"," Wang X"," Long J"," Liu J."],"journal":"Journal of biochemical and biophysical methods","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16740313","id":"16740313","citationCount":9,"stringAuthors":"Luo C,  Wang X,  Long J,  Liu J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16740313","resource":"16740313","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Identification of cold acclimation-responsive Rhododendron genes for lipid metabolism, membrane transport and lignin biosynthesis: importance of moderately abundant ESTs in genomic studies.","authors":["Wei H"," Dhanaraj AL"," Arora R"," Rowland LJ"," Fu Y"," Sun L."],"journal":"Plant, cell & environment","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17080607","id":"17080607","citationCount":21,"stringAuthors":"Wei H,  Dhanaraj AL,  Arora R,  Rowland LJ,  Fu Y,  Sun L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17080607","resource":"17080607","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"L-2-hydroxyglutaric aciduria, a defect of metabolite repair.","authors":["Rzem R"," Vincent MF"," Van Schaftingen E"," Veiga-da-Cunha M."],"journal":"Journal of inherited metabolic disease","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17603759","id":"17603759","citationCount":52,"stringAuthors":"Rzem R,  Vincent MF,  Van Schaftingen E,  Veiga-da-Cunha M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17603759","resource":"17603759","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ME3","resource":"ME3","type":"HGNC_SYMBOL"}]},{"name":"Peroxisomal bifunctional enzyme","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=EHHADH","resource":"EHHADH","type":"HGNC_SYMBOL"}]},{"name":"Peroxisomal multifunctional enzyme type 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Binary structure of the two-domain (3R)-hydroxyacyl-CoA dehydrogenase from rat peroxisomal multifunctional enzyme type 2 at 2.38 A resolution.","authors":["Haapalainen AM"," Koski MK"," Qin YM"," Hiltunen JK"," Glumoff T."],"journal":"Structure (London, England : 1993)","year":2003,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12517343","id":"12517343","citationCount":21,"stringAuthors":"Haapalainen AM,  Koski MK,  Qin YM,  Hiltunen JK,  Glumoff T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12517343","resource":"12517343","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B4","resource":"HSD17B4","type":"HGNC_SYMBOL"}]},{"name":"Pyrroline-5-carboxylate reductase 1, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Glutamine synthetase and glutamate dehydrogenase contribute differentially to proline accumulation in leaves of wheat (Triticum aestivum) seedlings exposed to different salinity.","authors":["Wang ZQ"," Yuan YZ"," Ou JQ"," Lin QH"," Zhang CF."],"journal":"Journal of plant physiology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16777263","id":"16777263","citationCount":28,"stringAuthors":"Wang ZQ,  Yuan YZ,  Ou JQ,  Lin QH,  Zhang CF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16777263","resource":"16777263","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Plant P5C reductase as a new target for aminomethylenebisphosphonates.","authors":["Forlani G"," Giberti S"," Berlicki L"," Petrollino D"," Kafarski P."],"journal":"Journal of agricultural and food chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17474756","id":"17474756","citationCount":13,"stringAuthors":"Forlani G,  Giberti S,  Berlicki L,  Petrollino D,  Kafarski P."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17474756","resource":"17474756","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PYCR1","resource":"PYCR1","type":"HGNC_SYMBOL"}]},{"name":"Pyrroline-5-carboxylate reductase 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Purification and characterization of Delta(1)-pyrroline-5-carboxylate reductase isoenzymes, indicating differential distribution in spinach (Spinacia oleracea L.) leaves.","authors":["Murahama M"," Yoshida T"," Hayashi F"," Ichino T"," Sanada Y"," Wada K."],"journal":"Plant & cell physiology","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11479381","id":"11479381","citationCount":15,"stringAuthors":"Murahama M,  Yoshida T,  Hayashi F,  Ichino T,  Sanada Y,  Wada K."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11479381","resource":"11479381","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PYCR2","resource":"PYCR2","type":"HGNC_SYMBOL"}]},{"name":"Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PDHA1","resource":"PDHA1","type":"HGNC_SYMBOL"}]},{"name":"Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PDHA2","resource":"PDHA2","type":"HGNC_SYMBOL"}]},{"name":"Pyruvate dehydrogenase E1 component subunit beta, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Regulation of pyruvate dehydrogenase in isolated rat liver mitochondria. Effects of octanoate, oxidation-reduction state, and adenosine triphosphate to adenosine diphosphate ratio.","authors":["Taylor SI"," Mukherjee C"," Jungas RL."],"journal":"The Journal of biological chemistry","year":1975,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1116996","id":"1116996","citationCount":34,"stringAuthors":"Taylor SI,  Mukherjee C,  Jungas RL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1116996","resource":"1116996","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PDHB","resource":"PDHB","type":"HGNC_SYMBOL"}]},{"name":"Retinal dehydrogenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Activities of cytosolic aldehyde dehydrogenase isozymes in colon cancer: determination using selective, fluorimetric assays.","authors":["WroczyÅ„ski P"," Nowak M"," Wierzchowski J"," Szubert A"," PolaÅ„ski J."],"journal":"Acta poloniae pharmaceutica","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16583981","id":"16583981","citationCount":3,"stringAuthors":"WroczyÅ„ski P,  Nowak M,  Wierzchowski J,  Szubert A,  PolaÅ„ski J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16583981","resource":"16583981","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal.","authors":["Russo J"," Barnes A"," Berger K"," Desgrosellier J"," Henderson J"," Kanters A"," Merkov L."],"journal":"BMC pharmacology","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11872149","id":"11872149","citationCount":10,"stringAuthors":"Russo J,  Barnes A,  Berger K,  Desgrosellier J,  Henderson J,  Kanters A,  Merkov L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11872149","resource":"11872149","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH1A1","resource":"ALDH1A1","type":"HGNC_SYMBOL"}]},{"name":"Retinal dehydrogenase 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The structure of retinal dehydrogenase type II at 2.7 A resolution: implications for retinal specificity.","authors":["Lamb AL"," Newcomer ME."],"journal":"Biochemistry","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10320326","id":"10320326","citationCount":51,"stringAuthors":"Lamb AL,  Newcomer ME."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10320326","resource":"10320326","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal.","authors":["Russo J"," Barnes A"," Berger K"," Desgrosellier J"," Henderson J"," Kanters A"," Merkov L."],"journal":"BMC pharmacology","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11872149","id":"11872149","citationCount":10,"stringAuthors":"Russo J,  Barnes A,  Berger K,  Desgrosellier J,  Henderson J,  Kanters A,  Merkov L."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11872149","resource":"11872149","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH1A2","resource":"ALDH1A2","type":"HGNC_SYMBOL"}]},{"name":"Ribosyldihydronicotinamide dehydrogenase [quinone]","references":[{"annotatorClassName":"","article":{"title":"Reduction of mitomycin C is catalysed by human recombinant NRH:quinone oxidoreductase 2 using reduced nicotinamide adenine dinucleotide as an electron donating co-factor.","authors":["Jamieson D"," Tung AT"," Knox RJ"," Boddy AV."],"journal":"British journal of cancer","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17031400","id":"17031400","citationCount":12,"stringAuthors":"Jamieson D,  Tung AT,  Knox RJ,  Boddy AV."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17031400","resource":"17031400","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NQO1 and NQO2 regulation of humoral immunity and autoimmunity.","authors":["Iskander K"," Li J"," Han S"," Zheng B"," Jaiswal AK."],"journal":"The Journal of biological chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16905546","id":"16905546","citationCount":28,"stringAuthors":"Iskander K,  Li J,  Han S,  Zheng B,  Jaiswal AK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16905546","resource":"16905546","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NQO2","resource":"NQO2","type":"HGNC_SYMBOL"}]},{"name":"Short-chain specific acyl-CoA dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ACADS","resource":"ACADS","type":"HGNC_SYMBOL"}]},{"name":"Sorbitol dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"Pyridine nucleotide redox abnormalities in diabetes.","authors":["Ido Y."],"journal":"Antioxidants & redox signaling","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","id":"17508915","citationCount":36,"stringAuthors":"Ido Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17508915","resource":"17508915","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase.","authors":["Klimacek M"," Hellmer H"," Nidetzky B."],"journal":"The Biochemical journal","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17343568","id":"17343568","citationCount":8,"stringAuthors":"Klimacek M,  Hellmer H,  Nidetzky B."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17343568","resource":"17343568","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SORD","resource":"SORD","type":"HGNC_SYMBOL"}]},{"name":"Steroid 17-alpha-hydroxylase/17,20 lyase","references":[{"annotatorClassName":"","article":{"title":"Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase.","authors":["Pandey AV"," Kempná P"," Hofer G"," Mullis PE"," Flück CE."],"journal":"Molecular endocrinology (Baltimore, Md.)","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17595315","id":"17595315","citationCount":49,"stringAuthors":"Pandey AV,  Kempná P,  Hofer G,  Mullis PE,  Flück CE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17595315","resource":"17595315","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=CYP17A1","resource":"CYP17A1","type":"HGNC_SYMBOL"}]},{"name":"Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Changes in gene expression associated with loss of function of the NSDHL sterol dehydrogenase in mouse embryonic fibroblasts.","authors":["Cunningham D"," Swartzlander D"," Liyanarachchi S"," Davuluri RV"," Herman GE."],"journal":"Journal of Lipid Research","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15805545","id":"15805545","citationCount":8,"stringAuthors":"Cunningham D,  Swartzlander D,  Liyanarachchi S,  Davuluri RV,  Herman GE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15805545","resource":"15805545","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NSDHL","resource":"NSDHL","type":"HGNC_SYMBOL"}]},{"name":"Succinate-semialdehyde dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH5A1","resource":"ALDH5A1","type":"HGNC_SYMBOL"}]},{"name":"Testosterone 17-beta-dehydrogenase 3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Relationship between steroids and pyridine nucleotides in the oxido-reduction catalyzed by the 17 beta-hydroxysteroid dehydrogenase purified from the porcine testicular microsomal fraction.","authors":["Inano H"," Tamaoki B."],"journal":"European journal of biochemistry","year":1975,"link":"http://www.ncbi.nlm.nih.gov/pubmed/237755","id":"237755","citationCount":9,"stringAuthors":"Inano H,  Tamaoki B."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/237755","resource":"237755","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B3","resource":"HSD17B3","type":"HGNC_SYMBOL"}]},{"name":"Trifunctional enzyme subunit alpha, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HADHA","resource":"HADHA","type":"HGNC_SYMBOL"}]},{"name":"Tyrosinase","references":[{"annotatorClassName":"","article":{"title":"Decolourization of azo dye methyl red by Saccharomyces cerevisiae MTCC 463.","authors":["Jadhav JP"," Parshetti GK"," Kalme SD"," Govindwar SP."],"journal":"Chemosphere","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17292452","id":"17292452","citationCount":47,"stringAuthors":"Jadhav JP,  Parshetti GK,  Kalme SD,  Govindwar SP."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17292452","resource":"17292452","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A potential role for cyclized quinones derived from dopamine, DOPA, and 3,4-dihydroxyphenylacetic acid in proteasomal inhibition.","authors":["Zafar KS"," Siegel D"," Ross D."],"journal":"Molecular pharmacology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16790533","id":"16790533","citationCount":38,"stringAuthors":"Zafar KS,  Siegel D,  Ross D."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16790533","resource":"16790533","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=TYR","resource":"TYR","type":"HGNC_SYMBOL"}]},{"name":"UDP-glucose 6-dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1017,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":190,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Regulatory mechanisms of UDP-glucuronic acid biosynthesis in cultured human skin fibroblasts.","authors":["Castellani AA"," De Luca G"," Rindi S"," Salvini R"," Tira ME."],"journal":"The Italian journal of biochemistry","year":1986,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3804697","id":"3804697","citationCount":2,"stringAuthors":"Castellani AA,  De Luca G,  Rindi S,  Salvini R,  Tira ME."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/3804697","resource":"3804697","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Mechanism of cadmium-decreased glucuronidation in the rat.","authors":["Alary J"," Cravedi JP"," Baradat M"," Carrera G."],"journal":"Biochemical pharmacology","year":1992,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1472079","id":"1472079","citationCount":3,"stringAuthors":"Alary J,  Cravedi JP,  Baradat M,  Carrera G."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/1472079","resource":"1472079","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=UGDH","resource":"UGDH","type":"HGNC_SYMBOL"}]}]}]
\ No newline at end of file
diff --git a/frontend-js/testFiles/apiCalls/projects/sample/drugs.search/query=aspirin&token=MOCK_TOKEN_ID& b/frontend-js/testFiles/apiCalls/projects/sample/drugs.search/query=aspirin&token=MOCK_TOKEN_ID&
index 64144816d0449f76fa2d9857adf2aadd350912a0..590233da45767fc6138574f5206b40fc042e4f97 100644
--- a/frontend-js/testFiles/apiCalls/projects/sample/drugs.search/query=aspirin&token=MOCK_TOKEN_ID&
+++ b/frontend-js/testFiles/apiCalls/projects/sample/drugs.search/query=aspirin&token=MOCK_TOKEN_ID&
@@ -1 +1 @@
-[{"bloodBrainBarrier":"YES","brandNames":["Acenterine","Acetophen","Adiro","Aspergum","Aspro","Bayer Aspirin","Easprin","Empirin","Nu-seals","Rhodine","Rhonal","Solprin","Solprin acid","St. Joseph Aspirin for Adults","Tasprin"],"description":"The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Acetylsalicylic acid also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5) ","id":"ASPIRIN","name":"ASPIRIN","references":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.drugbank.ca/drugs/DB00945","resource":"DB00945","type":"DRUGBANK"},{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL25","resource":"CHEMBL25","type":"CHEMBL_COMPOUND"}],"synonyms":["2-Acetoxybenzenecarboxylic acid","2-Acetoxybenzoic acid","Acetylsalicylate","Acetylsalicylsäure","acide 2-(acétyloxy)benzoïque","acide acétylsalicylique","ácido acetilsalicílico","Acidum acetylsalicylicum","ASA","Aspirin","Azetylsalizylsäure","o-acetoxybenzoic acid","O-acetylsalicylic acid","o-carboxyphenyl acetate","Polopiryna","salicylic acid acetate","8-hour bayer","ACETYLSALICYLIC ACID","ASPIRIN","Acetosalic Acid","Acetylsalicylic Acid","Bayer extra strength aspirin for migraine pain","Ecotrin","Equi-Prin","Measurin","Salicylic Acid Acetate"],"targets":[{"name":"5'-AMP-activated protein kinase","references":[{"annotatorClassName":"","article":{"title":"Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells.","authors":["Din FV"," Valanciute A"," Houde VP"," Zibrova D"," Green KA"," Sakamoto K"," Alessi DR"," Dunlop MG."],"journal":"Gastroenterology","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22406476","id":"22406476","citationCount":86,"stringAuthors":"Din FV,  Valanciute A,  Houde VP,  Zibrova D,  Green KA,  Sakamoto K,  Alessi DR,  Dunlop MG."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22406476","resource":"22406476","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The ancient drug salicylate directly activates AMP-activated protein kinase.","authors":["Hawley SA"," Fullerton MD"," Ross FA"," Schertzer JD"," Chevtzoff C"," Walker KJ"," Peggie MW"," Zibrova D"," Green KA"," Mustard KJ"," Kemp BE"," Sakamoto K"," Steinberg GR"," Hardie DG."],"journal":"Science (New York, N.Y.)","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22517326","id":"22517326","citationCount":215,"stringAuthors":"Hawley SA,  Fullerton MD,  Ross FA,  Schertzer JD,  Chevtzoff C,  Walker KJ,  Peggie MW,  Zibrova D,  Green KA,  Mustard KJ,  Kemp BE,  Sakamoto K,  Steinberg GR,  Hardie DG."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22517326","resource":"22517326","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PRKAA1","resource":"PRKAA1","type":"HGNC_SYMBOL"}]},{"name":"78 kDa glucose-regulated protein","references":[{"annotatorClassName":"","article":{"title":"Aspirin and salicylate bind to immunoglobulin heavy chain binding protein (BiP) and inhibit its ATPase activity in human fibroblasts.","authors":["Deng WG"," Ruan KH"," Du M"," Saunders MA"," Wu KK."],"journal":"The FASEB Journal","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11689471","id":"11689471","citationCount":9,"stringAuthors":"Deng WG,  Ruan KH,  Du M,  Saunders MA,  Wu KK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11689471","resource":"11689471","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSPA5","resource":"HSPA5","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C1","references":[{"annotatorClassName":"","article":{"title":"A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase.","authors":["Dhagat U"," Carbone V"," Chung RP"," Matsunaga T"," Endo S"," Hara A"," El-Kabbani O."],"journal":"Medicinal chemistry (Shariqah (United Arab Emirates))","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18045204","id":"18045204","citationCount":9,"stringAuthors":"Dhagat U,  Carbone V,  Chung RP,  Matsunaga T,  Endo S,  Hara A,  El-Kabbani O."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18045204","resource":"18045204","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C1","resource":"AKR1C1","type":"HGNC_SYMBOL"}]},{"name":"Cellular tumor antigen p53","references":[{"annotatorClassName":"","article":{"title":"Does aspirin acetylate multiple cellular proteins? (Review).","authors":["Alfonso LF"," Srivenugopal KS"," Bhat GJ."],"journal":"Molecular medicine reports","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21475861","id":"21475861","citationCount":7,"stringAuthors":"Alfonso LF,  Srivenugopal KS,  Bhat GJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21475861","resource":"21475861","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=TP53","resource":"TP53","type":"HGNC_SYMBOL"}]},{"name":"Cyclooxygenase","references":[{"annotatorClassName":"","article":{"title":"Interaction between cyclooxygenase (COX)-1- and COX-2-products modulates COX-2 expression in the late phase of acute inflammation.","authors":["Nakano M"," Denda N"," Matsumoto M"," Kawamura M"," Kawakubo Y"," Hatanaka K"," Hiramoto Y"," Sato Y"," Noshiro M"," Harada Y."],"journal":"European journal of pharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17258197","id":"17258197","citationCount":5,"stringAuthors":"Nakano M,  Denda N,  Matsumoto M,  Kawamura M,  Kawakubo Y,  Hatanaka K,  Hiramoto Y,  Sato Y,  Noshiro M,  Harada Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17258197","resource":"17258197","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Aspirin resistance: a review of diagnostic methodology, mechanisms, and clinical utility.","authors":["Schwartz KA."],"journal":"Advances in clinical chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17131625","id":"17131625","citationCount":5,"stringAuthors":"Schwartz KA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17131625","resource":"17131625","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PTGS1","resource":"PTGS1","type":"HGNC_SYMBOL"},{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PTGS2","resource":"PTGS2","type":"HGNC_SYMBOL"}]},{"name":"Endothelin-1 receptor","references":[{"annotatorClassName":"","article":{"title":"Aspirin and sodium salicylate inhibit endothelin ETA receptors by an allosteric type of mechanism.","authors":["Talbodec A"," Berkane N"," Blandin V"," Breittmayer JP"," Ferrari E"," Frelin C"," Vigne P."],"journal":"Molecular pharmacology","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10727528","id":"10727528","citationCount":11,"stringAuthors":"Talbodec A,  Berkane N,  Blandin V,  Breittmayer JP,  Ferrari E,  Frelin C,  Vigne P."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10727528","resource":"10727528","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=EDNRA","resource":"EDNRA","type":"HGNC_SYMBOL"}]},{"name":"Inhibitor of nuclear factor kappa-B kinase subunit beta","references":[{"annotatorClassName":"","article":{"title":"The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta.","authors":["Yin MJ"," Yamamoto Y"," Gaynor RB."],"journal":"Nature","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9817203","id":"9817203","citationCount":637,"stringAuthors":"Yin MJ,  Yamamoto Y,  Gaynor RB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9817203","resource":"9817203","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IKBKB","resource":"IKBKB","type":"HGNC_SYMBOL"}]},{"name":"NF-kappa-B inhibitor alpha","references":[{"annotatorClassName":"","article":{"title":"Salicylic acid and aspirin inhibit the activity of RSK2 kinase and repress RSK2-dependent transcription of cyclic AMP response element binding protein- and NF-kappa B-responsive genes.","authors":["Stevenson MA"," Zhao MJ"," Asea A"," Coleman CN"," Calderwood SK."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10553090","id":"10553090","citationCount":22,"stringAuthors":"Stevenson MA,  Zhao MJ,  Asea A,  Coleman CN,  Calderwood SK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10553090","resource":"10553090","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NFKBIA","resource":"NFKBIA","type":"HGNC_SYMBOL"}]},{"name":"Nuclear factor NF-kappa-B","references":[{"annotatorClassName":"","article":{"title":"Inhibition of NF-kappa B by sodium salicylate and aspirin.","authors":["Kopp E"," Ghosh S."],"journal":"Science (New York, N.Y.)","year":1994,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8052854","id":"8052854","citationCount":733,"stringAuthors":"Kopp E,  Ghosh S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8052854","resource":"8052854","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NFKB2","resource":"NFKB2","type":"HGNC_SYMBOL"}]},{"name":"Prostaglandin G/H synthase 1","references":[{"annotatorClassName":"","article":{"title":"Clinical and pathologic perspectives on aspirin sensitivity and asthma.","authors":["Stevenson DD"," Szczeklik A."],"journal":"The Journal of allergy and clinical immunology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17030227","id":"17030227","citationCount":95,"stringAuthors":"Stevenson DD,  Szczeklik A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17030227","resource":"17030227","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"[Are the NSAIDs able to compromising the cardio-preventive efficacy of aspirin?].","authors":["Flipo RM."],"journal":"Presse medicale (Paris, France : 1983)","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17078596","id":"17078596","citationCount":0,"stringAuthors":"Flipo RM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17078596","resource":"17078596","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Aspirin resistance: a review of diagnostic methodology, mechanisms, and clinical utility.","authors":["Schwartz KA."],"journal":"Advances in clinical chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17131625","id":"17131625","citationCount":5,"stringAuthors":"Schwartz KA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17131625","resource":"17131625","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Aspirin augments 15-epi-lipoxin A4 production by lipopolysaccharide, but blocks the pioglitazone and atorvastatin induction of 15-epi-lipoxin A4 in the rat heart.","authors":["Birnbaum Y"," Ye Y"," Lin Y"," Freeberg SY"," Huang MH"," Perez-Polo JR"," Uretsky BF."],"journal":"Prostaglandins & other lipid mediators","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17259075","id":"17259075","citationCount":19,"stringAuthors":"Birnbaum Y,  Ye Y,  Lin Y,  Freeberg SY,  Huang MH,  Perez-Polo JR,  Uretsky BF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17259075","resource":"17259075","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirin.","authors":["Guthikonda S"," Lev EI"," Patel R"," DeLao T"," Bergeron AL"," Dong JF"," Kleiman NS."],"journal":"Journal of thrombosis and haemostasis : JTH","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17319904","id":"17319904","citationCount":87,"stringAuthors":"Guthikonda S,  Lev EI,  Patel R,  DeLao T,  Bergeron AL,  Dong JF,  Kleiman NS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17319904","resource":"17319904","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"TTD: Therapeutic Target Database.","authors":["Chen X"," Ji ZL"," Chen YZ."],"journal":"Nucleic acids research","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","id":"11752352","citationCount":104,"stringAuthors":"Chen X,  Ji ZL,  Chen YZ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","resource":"11752352","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors.","authors":["Handler N"," Brunhofer G"," Studenik C"," Leisser K"," Jaeger W"," Parth S"," Erker T."],"journal":"Bioorganic & medicinal chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17604631","id":"17604631","citationCount":14,"stringAuthors":"Handler N,  Brunhofer G,  Studenik C,  Leisser K,  Jaeger W,  Parth S,  Erker T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17604631","resource":"17604631","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"3-Formylchromones: potential antiinflammatory agents.","authors":["Khan KM"," Ambreen N"," Mughal UR"," Jalil S"," Perveen S"," Choudhary MI."],"journal":"European journal of medicinal chemistry","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20576329","id":"20576329","citationCount":11,"stringAuthors":"Khan KM,  Ambreen N,  Mughal UR,  Jalil S,  Perveen S,  Choudhary MI."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20576329","resource":"20576329","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries.","authors":["Wang H"," Nair MG"," Strasburg GM"," Chang YC"," Booren AM"," Gray JI"," DeWitt DL."],"journal":"Journal of natural products","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10075763","id":"10075763","citationCount":172,"stringAuthors":"Wang H,  Nair MG,  Strasburg GM,  Chang YC,  Booren AM,  Gray JI,  DeWitt DL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10075763","resource":"10075763","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"N-Caffeoyl serotonin as selective COX-2 inhibitor.","authors":["Takahashi T"," Miyazawa M."],"journal":"Bioorganic & medicinal chemistry letters","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22386242","id":"22386242","citationCount":3,"stringAuthors":"Takahashi T,  Miyazawa M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22386242","resource":"22386242","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Antiinflammatory 4,5-diarylpyrroles. 2. Activity as a function of cyclooxygenase-2 inhibition.","authors":["Wilkerson WW"," Copeland RA"," Covington M"," Trzaskos JM."],"journal":"Journal of medicinal chemistry","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7562922","id":"7562922","citationCount":7,"stringAuthors":"Wilkerson WW,  Copeland RA,  Covington M,  Trzaskos JM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7562922","resource":"7562922","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Bioactive compounds from Bauhinia purpurea possessing antimalarial, antimycobacterial, antifungal, anti-inflammatory, and cytotoxic activities.","authors":["Boonphong S"," Puangsombat P"," Baramee A"," Mahidol C"," Ruchirawat S"," Kittakoop P."],"journal":"Journal of natural products","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17480099","id":"17480099","citationCount":17,"stringAuthors":"Boonphong S,  Puangsombat P,  Baramee A,  Mahidol C,  Ruchirawat S,  Kittakoop P."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17480099","resource":"17480099","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies.","authors":["Abdellatif KR"," Chowdhury MA"," Dong Y"," Das D"," Yu G"," Velázquez C"," Suresh MR"," Knaus EE."],"journal":"Bioorganic & medicinal chemistry","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19500994","id":"19500994","citationCount":10,"stringAuthors":"Abdellatif KR,  Chowdhury MA,  Dong Y,  Das D,  Yu G,  Velázquez C,  Suresh MR,  Knaus EE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19500994","resource":"19500994","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.","authors":["Chowdhury MA"," Abdellatif KR"," Dong Y"," Das D"," Yu G"," Velázquez CA"," Suresh MR"," Knaus EE."],"journal":"Bioorganic & medicinal chemistry letters","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19884005","id":"19884005","citationCount":10,"stringAuthors":"Chowdhury MA,  Abdellatif KR,  Dong Y,  Das D,  Yu G,  Velázquez CA,  Suresh MR,  Knaus EE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19884005","resource":"19884005","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.","authors":["Chowdhury MA"," Abdellatif KR"," Dong Y"," Yu G"," Huang Z"," Rahman M"," Das D"," Velázquez CA"," Suresh MR"," Knaus EE."],"journal":"Bioorganic & medicinal chemistry letters","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20097072","id":"20097072","citationCount":19,"stringAuthors":"Chowdhury MA,  Abdellatif KR,  Dong Y,  Yu G,  Huang Z,  Rahman M,  Das D,  Velázquez CA,  Suresh MR,  Knaus EE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20097072","resource":"20097072","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.","authors":["Abdellatif KR"," Chowdhury MA"," Velázquez CA"," Huang Z"," Dong Y"," Das D"," Yu G"," Suresh MR"," Knaus EE."],"journal":"Bioorganic & medicinal chemistry letters","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20576432","id":"20576432","citationCount":8,"stringAuthors":"Abdellatif KR,  Chowdhury MA,  Velázquez CA,  Huang Z,  Dong Y,  Das D,  Yu G,  Suresh MR,  Knaus EE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20576432","resource":"20576432","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs.","authors":["Jain S"," Tran S"," El Gendy MA"," Kashfi K"," Jurasz P"," Velázquez-Martínez CA."],"journal":"Journal of medicinal chemistry","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22148253","id":"22148253","citationCount":4,"stringAuthors":"Jain S,  Tran S,  El Gendy MA,  Kashfi K,  Jurasz P,  Velázquez-Martínez CA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22148253","resource":"22148253","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"N-1 and C-3 substituted indole Schiff bases as selective COX-2 inhibitors: synthesis and biological evaluation.","authors":["Kaur J"," Bhardwaj A"," Huang Z"," Knaus EE."],"journal":"Bioorganic & medicinal chemistry letters","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22361134","id":"22361134","citationCount":7,"stringAuthors":"Kaur J,  Bhardwaj A,  Huang Z,  Knaus EE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22361134","resource":"22361134","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker.","authors":["Bhardwaj A"," Kaur J"," Sharma SK"," Huang Z"," Wuest F"," Knaus EE."],"journal":"Bioorganic & medicinal chemistry letters","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23200247","id":"23200247","citationCount":10,"stringAuthors":"Bhardwaj A,  Kaur J,  Sharma SK,  Huang Z,  Wuest F,  Knaus EE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23200247","resource":"23200247","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.","authors":["Rao PN"," Chen QH"," Knaus EE."],"journal":"Journal of medicinal chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16509583","id":"16509583","citationCount":22,"stringAuthors":"Rao PN,  Chen QH,  Knaus EE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16509583","resource":"16509583","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators.","authors":["Kalgutkar AS"," Kozak KR"," Crews BC"," Hochgesang GP"," Marnett LJ."],"journal":"Journal of medicinal chemistry","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9822550","id":"9822550","citationCount":33,"stringAuthors":"Kalgutkar AS,  Kozak KR,  Crews BC,  Hochgesang GP,  Marnett LJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9822550","resource":"9822550","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor.","authors":["Kakuta H"," Zheng X"," Oda H"," Harada S"," Sugimoto Y"," Sasaki K"," Tai A."],"journal":"Journal of medicinal chemistry","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18363350","id":"18363350","citationCount":20,"stringAuthors":"Kakuta H,  Zheng X,  Oda H,  Harada S,  Sugimoto Y,  Sasaki K,  Tai A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18363350","resource":"18363350","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs.","authors":["Cryer B"," Feldman M."],"journal":"The American journal of medicine","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9626023","id":"9626023","citationCount":252,"stringAuthors":"Cryer B,  Feldman M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9626023","resource":"9626023","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis.","authors":["Warner TD"," Giuliano F"," Vojnovic I"," Bukasa A"," Mitchell JA"," Vane JR."],"journal":"Proceedings of the National Academy of Sciences of the United States of America","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10377455","id":"10377455","citationCount":550,"stringAuthors":"Warner TD,  Giuliano F,  Vojnovic I,  Bukasa A,  Mitchell JA,  Vane JR."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10377455","resource":"10377455","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis.","authors":["Warner TD"," Giuliano F"," Vojnovic I"," Bukasa A"," Mitchell JA"," Vane JR."],"journal":"Proceedings of the National Academy of Sciences of the United States of America","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10377455","id":"10377455","citationCount":550,"stringAuthors":"Warner TD,  Giuliano F,  Vojnovic I,  Bukasa A,  Mitchell JA,  Vane JR."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10377455","resource":"10377455","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PTGS1","resource":"PTGS1","type":"HGNC_SYMBOL"}]},{"name":"Prostaglandin G/H synthase 2","references":[{"annotatorClassName":"","article":{"title":"Interaction of nonsteroidal anti-inflammatory drugs (NSAID) with Helicobacter pylori in the stomach of humans and experimental animals.","authors":["Brzozowski T"," Konturek PC"," Sliwowski Z"," KwiecieÅ„ S"," Drozdowicz D"," Pawlik M"," Mach K"," Konturek SJ"," Pawlik WW."],"journal":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17033106","id":"17033106","citationCount":18,"stringAuthors":"Brzozowski T,  Konturek PC,  Sliwowski Z,  KwiecieÅ„ S,  Drozdowicz D,  Pawlik M,  Mach K,  Konturek SJ,  Pawlik WW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17033106","resource":"17033106","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"[Effects of nonsteroidal anti-inflammatory drug celecoxib on expression of cyclooxygenase-2 (COX-2) in ovarian carcinoma cell].","authors":["Wang HJ"," Liu XJ"," Yang KX"," Luo FM"," Lou JY"," Peng ZL."],"journal":"Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17037745","id":"17037745","citationCount":0,"stringAuthors":"Wang HJ,  Liu XJ,  Yang KX,  Luo FM,  Lou JY,  Peng ZL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17037745","resource":"17037745","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Genetic polymorphisms in the cyclooxygenase-2 gene, use of nonsteroidal anti-inflammatory drugs, and breast cancer risk.","authors":["Shen J"," Gammon MD"," Terry MB"," Teitelbaum SL"," Neugut AI"," Santella RM."],"journal":"Breast cancer research : BCR","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17181859","id":"17181859","citationCount":28,"stringAuthors":"Shen J,  Gammon MD,  Terry MB,  Teitelbaum SL,  Neugut AI,  Santella RM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17181859","resource":"17181859","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Interaction between cyclooxygenase (COX)-1- and COX-2-products modulates COX-2 expression in the late phase of acute inflammation.","authors":["Nakano M"," Denda N"," Matsumoto M"," Kawamura M"," Kawakubo Y"," Hatanaka K"," Hiramoto Y"," Sato Y"," Noshiro M"," Harada Y."],"journal":"European journal of pharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17258197","id":"17258197","citationCount":5,"stringAuthors":"Nakano M,  Denda N,  Matsumoto M,  Kawamura M,  Kawakubo Y,  Hatanaka K,  Hiramoto Y,  Sato Y,  Noshiro M,  Harada Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17258197","resource":"17258197","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Blood levels of long-chain polyunsaturated fatty acids, aspirin, and the risk of colorectal cancer.","authors":["Hall MN"," Campos H"," Li H"," Sesso HD"," Stampfer MJ"," Willett WC"," Ma J."],"journal":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17301265","id":"17301265","citationCount":33,"stringAuthors":"Hall MN,  Campos H,  Li H,  Sesso HD,  Stampfer MJ,  Willett WC,  Ma J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17301265","resource":"17301265","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"TTD: Therapeutic Target Database.","authors":["Chen X"," Ji ZL"," Chen YZ."],"journal":"Nucleic acids research","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","id":"11752352","citationCount":104,"stringAuthors":"Chen X,  Ji ZL,  Chen YZ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","resource":"11752352","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PTGS2","resource":"PTGS2","type":"HGNC_SYMBOL"}]},{"name":"Ribosomal protein S6 kinase alpha-3","references":[{"annotatorClassName":"","article":{"title":"Salicylic acid and aspirin inhibit the activity of RSK2 kinase and repress RSK2-dependent transcription of cyclic AMP response element binding protein- and NF-kappa B-responsive genes.","authors":["Stevenson MA"," Zhao MJ"," Asea A"," Coleman CN"," Calderwood SK."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10553090","id":"10553090","citationCount":22,"stringAuthors":"Stevenson MA,  Zhao MJ,  Asea A,  Coleman CN,  Calderwood SK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10553090","resource":"10553090","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=RPS6KA3","resource":"RPS6KA3","type":"HGNC_SYMBOL"}]}]}]
\ No newline at end of file
+[{"bloodBrainBarrier":"YES","brandNames":["Acenterine","Acetophen","Adiro","Aspergum","Aspro","Bayer Aspirin","Easprin","Empirin","Nu-seals","Rhodine","Rhonal","Solprin","Solprin acid","St. Joseph Aspirin for Adults","Tasprin"],"description":"The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Acetylsalicylic acid also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5) ","id":"ASPIRIN","name":"ASPIRIN","references":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.drugbank.ca/drugs/DB00945","resource":"DB00945","type":"DRUGBANK"},{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL25","resource":"CHEMBL25","type":"CHEMBL_COMPOUND"}],"synonyms":["2-Acetoxybenzenecarboxylic acid","2-Acetoxybenzoic acid","Acetylsalicylate","Acetylsalicylsäure","acide 2-(acétyloxy)benzoïque","acide acétylsalicylique","ácido acetilsalicílico","Acidum acetylsalicylicum","ASA","Aspirin","Azetylsalizylsäure","o-acetoxybenzoic acid","O-acetylsalicylic acid","o-carboxyphenyl acetate","Polopiryna","salicylic acid acetate","8-hour bayer","ACETYLSALICYLIC ACID","ASPIRIN","Acetosalic Acid","Acetylsalicylic Acid","Bayer extra strength aspirin for migraine pain","Ecotrin","Equi-Prin","Measurin","Salicylic Acid Acetate"],"targets":[{"name":"5'-AMP-activated protein kinase","references":[{"annotatorClassName":"","article":{"title":"Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells.","authors":["Din FV"," Valanciute A"," Houde VP"," Zibrova D"," Green KA"," Sakamoto K"," Alessi DR"," Dunlop MG."],"journal":"Gastroenterology","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22406476","id":"22406476","citationCount":86,"stringAuthors":"Din FV,  Valanciute A,  Houde VP,  Zibrova D,  Green KA,  Sakamoto K,  Alessi DR,  Dunlop MG."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22406476","resource":"22406476","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The ancient drug salicylate directly activates AMP-activated protein kinase.","authors":["Hawley SA"," Fullerton MD"," Ross FA"," Schertzer JD"," Chevtzoff C"," Walker KJ"," Peggie MW"," Zibrova D"," Green KA"," Mustard KJ"," Kemp BE"," Sakamoto K"," Steinberg GR"," Hardie DG."],"journal":"Science (New York, N.Y.)","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22517326","id":"22517326","citationCount":215,"stringAuthors":"Hawley SA,  Fullerton MD,  Ross FA,  Schertzer JD,  Chevtzoff C,  Walker KJ,  Peggie MW,  Zibrova D,  Green KA,  Mustard KJ,  Kemp BE,  Sakamoto K,  Steinberg GR,  Hardie DG."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22517326","resource":"22517326","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PRKAA1","resource":"PRKAA1","type":"HGNC_SYMBOL"}]},{"name":"78 kDa glucose-regulated protein","references":[{"annotatorClassName":"","article":{"title":"Aspirin and salicylate bind to immunoglobulin heavy chain binding protein (BiP) and inhibit its ATPase activity in human fibroblasts.","authors":["Deng WG"," Ruan KH"," Du M"," Saunders MA"," Wu KK."],"journal":"The FASEB Journal","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11689471","id":"11689471","citationCount":9,"stringAuthors":"Deng WG,  Ruan KH,  Du M,  Saunders MA,  Wu KK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11689471","resource":"11689471","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSPA5","resource":"HSPA5","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C1","references":[{"annotatorClassName":"","article":{"title":"A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase.","authors":["Dhagat U"," Carbone V"," Chung RP"," Matsunaga T"," Endo S"," Hara A"," El-Kabbani O."],"journal":"Medicinal chemistry (Shariqah (United Arab Emirates))","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18045204","id":"18045204","citationCount":9,"stringAuthors":"Dhagat U,  Carbone V,  Chung RP,  Matsunaga T,  Endo S,  Hara A,  El-Kabbani O."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18045204","resource":"18045204","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C1","resource":"AKR1C1","type":"HGNC_SYMBOL"}]},{"name":"Cellular tumor antigen p53","references":[{"annotatorClassName":"","article":{"title":"Does aspirin acetylate multiple cellular proteins? (Review).","authors":["Alfonso LF"," Srivenugopal KS"," Bhat GJ."],"journal":"Molecular medicine reports","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21475861","id":"21475861","citationCount":7,"stringAuthors":"Alfonso LF,  Srivenugopal KS,  Bhat GJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21475861","resource":"21475861","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=TP53","resource":"TP53","type":"HGNC_SYMBOL"}]},{"name":"Cyclooxygenase","references":[{"annotatorClassName":"","article":{"title":"Interaction between cyclooxygenase (COX)-1- and COX-2-products modulates COX-2 expression in the late phase of acute inflammation.","authors":["Nakano M"," Denda N"," Matsumoto M"," Kawamura M"," Kawakubo Y"," Hatanaka K"," Hiramoto Y"," Sato Y"," Noshiro M"," Harada Y."],"journal":"European journal of pharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17258197","id":"17258197","citationCount":5,"stringAuthors":"Nakano M,  Denda N,  Matsumoto M,  Kawamura M,  Kawakubo Y,  Hatanaka K,  Hiramoto Y,  Sato Y,  Noshiro M,  Harada Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17258197","resource":"17258197","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Aspirin resistance: a review of diagnostic methodology, mechanisms, and clinical utility.","authors":["Schwartz KA."],"journal":"Advances in clinical chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17131625","id":"17131625","citationCount":5,"stringAuthors":"Schwartz KA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17131625","resource":"17131625","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PTGS1","resource":"PTGS1","type":"HGNC_SYMBOL"},{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PTGS2","resource":"PTGS2","type":"HGNC_SYMBOL"}]},{"name":"Endothelin-1 receptor","references":[{"annotatorClassName":"","article":{"title":"Aspirin and sodium salicylate inhibit endothelin ETA receptors by an allosteric type of mechanism.","authors":["Talbodec A"," Berkane N"," Blandin V"," Breittmayer JP"," Ferrari E"," Frelin C"," Vigne P."],"journal":"Molecular pharmacology","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10727528","id":"10727528","citationCount":11,"stringAuthors":"Talbodec A,  Berkane N,  Blandin V,  Breittmayer JP,  Ferrari E,  Frelin C,  Vigne P."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10727528","resource":"10727528","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=EDNRA","resource":"EDNRA","type":"HGNC_SYMBOL"}]},{"name":"Inhibitor of nuclear factor kappa-B kinase subunit beta","references":[{"annotatorClassName":"","article":{"title":"The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta.","authors":["Yin MJ"," Yamamoto Y"," Gaynor RB."],"journal":"Nature","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9817203","id":"9817203","citationCount":637,"stringAuthors":"Yin MJ,  Yamamoto Y,  Gaynor RB."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9817203","resource":"9817203","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IKBKB","resource":"IKBKB","type":"HGNC_SYMBOL"}]},{"name":"NF-kappa-B inhibitor alpha","references":[{"annotatorClassName":"","article":{"title":"Salicylic acid and aspirin inhibit the activity of RSK2 kinase and repress RSK2-dependent transcription of cyclic AMP response element binding protein- and NF-kappa B-responsive genes.","authors":["Stevenson MA"," Zhao MJ"," Asea A"," Coleman CN"," Calderwood SK."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10553090","id":"10553090","citationCount":22,"stringAuthors":"Stevenson MA,  Zhao MJ,  Asea A,  Coleman CN,  Calderwood SK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10553090","resource":"10553090","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NFKBIA","resource":"NFKBIA","type":"HGNC_SYMBOL"}]},{"name":"Nuclear factor NF-kappa-B","references":[{"annotatorClassName":"","article":{"title":"Inhibition of NF-kappa B by sodium salicylate and aspirin.","authors":["Kopp E"," Ghosh S."],"journal":"Science (New York, N.Y.)","year":1994,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8052854","id":"8052854","citationCount":733,"stringAuthors":"Kopp E,  Ghosh S."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8052854","resource":"8052854","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NFKB2","resource":"NFKB2","type":"HGNC_SYMBOL"}]},{"name":"Prostaglandin G/H synthase 1","references":[{"annotatorClassName":"","article":{"title":"Clinical and pathologic perspectives on aspirin sensitivity and asthma.","authors":["Stevenson DD"," Szczeklik A."],"journal":"The Journal of allergy and clinical immunology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17030227","id":"17030227","citationCount":113,"stringAuthors":"Stevenson DD,  Szczeklik A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17030227","resource":"17030227","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"[Are the NSAIDs able to compromising the cardio-preventive efficacy of aspirin?].","authors":["Flipo RM."],"journal":"Presse medicale (Paris, France : 1983)","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17078596","id":"17078596","citationCount":0,"stringAuthors":"Flipo RM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17078596","resource":"17078596","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Aspirin resistance: a review of diagnostic methodology, mechanisms, and clinical utility.","authors":["Schwartz KA."],"journal":"Advances in clinical chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17131625","id":"17131625","citationCount":5,"stringAuthors":"Schwartz KA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17131625","resource":"17131625","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Aspirin augments 15-epi-lipoxin A4 production by lipopolysaccharide, but blocks the pioglitazone and atorvastatin induction of 15-epi-lipoxin A4 in the rat heart.","authors":["Birnbaum Y"," Ye Y"," Lin Y"," Freeberg SY"," Huang MH"," Perez-Polo JR"," Uretsky BF."],"journal":"Prostaglandins & other lipid mediators","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17259075","id":"17259075","citationCount":19,"stringAuthors":"Birnbaum Y,  Ye Y,  Lin Y,  Freeberg SY,  Huang MH,  Perez-Polo JR,  Uretsky BF."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17259075","resource":"17259075","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirin.","authors":["Guthikonda S"," Lev EI"," Patel R"," DeLao T"," Bergeron AL"," Dong JF"," Kleiman NS."],"journal":"Journal of thrombosis and haemostasis : JTH","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17319904","id":"17319904","citationCount":87,"stringAuthors":"Guthikonda S,  Lev EI,  Patel R,  DeLao T,  Bergeron AL,  Dong JF,  Kleiman NS."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17319904","resource":"17319904","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"TTD: Therapeutic Target Database.","authors":["Chen X"," Ji ZL"," Chen YZ."],"journal":"Nucleic acids research","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","id":"11752352","citationCount":104,"stringAuthors":"Chen X,  Ji ZL,  Chen YZ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","resource":"11752352","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors.","authors":["Handler N"," Brunhofer G"," Studenik C"," Leisser K"," Jaeger W"," Parth S"," Erker T."],"journal":"Bioorganic & medicinal chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17604631","id":"17604631","citationCount":14,"stringAuthors":"Handler N,  Brunhofer G,  Studenik C,  Leisser K,  Jaeger W,  Parth S,  Erker T."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17604631","resource":"17604631","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"3-Formylchromones: potential antiinflammatory agents.","authors":["Khan KM"," Ambreen N"," Mughal UR"," Jalil S"," Perveen S"," Choudhary MI."],"journal":"European journal of medicinal chemistry","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20576329","id":"20576329","citationCount":11,"stringAuthors":"Khan KM,  Ambreen N,  Mughal UR,  Jalil S,  Perveen S,  Choudhary MI."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20576329","resource":"20576329","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries.","authors":["Wang H"," Nair MG"," Strasburg GM"," Chang YC"," Booren AM"," Gray JI"," DeWitt DL."],"journal":"Journal of natural products","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10075763","id":"10075763","citationCount":172,"stringAuthors":"Wang H,  Nair MG,  Strasburg GM,  Chang YC,  Booren AM,  Gray JI,  DeWitt DL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10075763","resource":"10075763","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"N-Caffeoyl serotonin as selective COX-2 inhibitor.","authors":["Takahashi T"," Miyazawa M."],"journal":"Bioorganic & medicinal chemistry letters","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22386242","id":"22386242","citationCount":3,"stringAuthors":"Takahashi T,  Miyazawa M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22386242","resource":"22386242","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Antiinflammatory 4,5-diarylpyrroles. 2. Activity as a function of cyclooxygenase-2 inhibition.","authors":["Wilkerson WW"," Copeland RA"," Covington M"," Trzaskos JM."],"journal":"Journal of medicinal chemistry","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7562922","id":"7562922","citationCount":7,"stringAuthors":"Wilkerson WW,  Copeland RA,  Covington M,  Trzaskos JM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7562922","resource":"7562922","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Bioactive compounds from Bauhinia purpurea possessing antimalarial, antimycobacterial, antifungal, anti-inflammatory, and cytotoxic activities.","authors":["Boonphong S"," Puangsombat P"," Baramee A"," Mahidol C"," Ruchirawat S"," Kittakoop P."],"journal":"Journal of natural products","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17480099","id":"17480099","citationCount":17,"stringAuthors":"Boonphong S,  Puangsombat P,  Baramee A,  Mahidol C,  Ruchirawat S,  Kittakoop P."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17480099","resource":"17480099","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies.","authors":["Abdellatif KR"," Chowdhury MA"," Dong Y"," Das D"," Yu G"," Velázquez C"," Suresh MR"," Knaus EE."],"journal":"Bioorganic & medicinal chemistry","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19500994","id":"19500994","citationCount":10,"stringAuthors":"Abdellatif KR,  Chowdhury MA,  Dong Y,  Das D,  Yu G,  Velázquez C,  Suresh MR,  Knaus EE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19500994","resource":"19500994","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.","authors":["Chowdhury MA"," Abdellatif KR"," Dong Y"," Das D"," Yu G"," Velázquez CA"," Suresh MR"," Knaus EE."],"journal":"Bioorganic & medicinal chemistry letters","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19884005","id":"19884005","citationCount":10,"stringAuthors":"Chowdhury MA,  Abdellatif KR,  Dong Y,  Das D,  Yu G,  Velázquez CA,  Suresh MR,  Knaus EE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19884005","resource":"19884005","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.","authors":["Chowdhury MA"," Abdellatif KR"," Dong Y"," Yu G"," Huang Z"," Rahman M"," Das D"," Velázquez CA"," Suresh MR"," Knaus EE."],"journal":"Bioorganic & medicinal chemistry letters","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20097072","id":"20097072","citationCount":19,"stringAuthors":"Chowdhury MA,  Abdellatif KR,  Dong Y,  Yu G,  Huang Z,  Rahman M,  Das D,  Velázquez CA,  Suresh MR,  Knaus EE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20097072","resource":"20097072","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.","authors":["Abdellatif KR"," Chowdhury MA"," Velázquez CA"," Huang Z"," Dong Y"," Das D"," Yu G"," Suresh MR"," Knaus EE."],"journal":"Bioorganic & medicinal chemistry letters","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20576432","id":"20576432","citationCount":8,"stringAuthors":"Abdellatif KR,  Chowdhury MA,  Velázquez CA,  Huang Z,  Dong Y,  Das D,  Yu G,  Suresh MR,  Knaus EE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20576432","resource":"20576432","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs.","authors":["Jain S"," Tran S"," El Gendy MA"," Kashfi K"," Jurasz P"," Velázquez-Martínez CA."],"journal":"Journal of medicinal chemistry","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22148253","id":"22148253","citationCount":4,"stringAuthors":"Jain S,  Tran S,  El Gendy MA,  Kashfi K,  Jurasz P,  Velázquez-Martínez CA."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22148253","resource":"22148253","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"N-1 and C-3 substituted indole Schiff bases as selective COX-2 inhibitors: synthesis and biological evaluation.","authors":["Kaur J"," Bhardwaj A"," Huang Z"," Knaus EE."],"journal":"Bioorganic & medicinal chemistry letters","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22361134","id":"22361134","citationCount":7,"stringAuthors":"Kaur J,  Bhardwaj A,  Huang Z,  Knaus EE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22361134","resource":"22361134","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker.","authors":["Bhardwaj A"," Kaur J"," Sharma SK"," Huang Z"," Wuest F"," Knaus EE."],"journal":"Bioorganic & medicinal chemistry letters","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23200247","id":"23200247","citationCount":10,"stringAuthors":"Bhardwaj A,  Kaur J,  Sharma SK,  Huang Z,  Wuest F,  Knaus EE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23200247","resource":"23200247","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.","authors":["Rao PN"," Chen QH"," Knaus EE."],"journal":"Journal of medicinal chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16509583","id":"16509583","citationCount":22,"stringAuthors":"Rao PN,  Chen QH,  Knaus EE."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16509583","resource":"16509583","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators.","authors":["Kalgutkar AS"," Kozak KR"," Crews BC"," Hochgesang GP"," Marnett LJ."],"journal":"Journal of medicinal chemistry","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9822550","id":"9822550","citationCount":33,"stringAuthors":"Kalgutkar AS,  Kozak KR,  Crews BC,  Hochgesang GP,  Marnett LJ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9822550","resource":"9822550","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor.","authors":["Kakuta H"," Zheng X"," Oda H"," Harada S"," Sugimoto Y"," Sasaki K"," Tai A."],"journal":"Journal of medicinal chemistry","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18363350","id":"18363350","citationCount":20,"stringAuthors":"Kakuta H,  Zheng X,  Oda H,  Harada S,  Sugimoto Y,  Sasaki K,  Tai A."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18363350","resource":"18363350","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs.","authors":["Cryer B"," Feldman M."],"journal":"The American journal of medicine","year":1998,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9626023","id":"9626023","citationCount":252,"stringAuthors":"Cryer B,  Feldman M."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/9626023","resource":"9626023","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis.","authors":["Warner TD"," Giuliano F"," Vojnovic I"," Bukasa A"," Mitchell JA"," Vane JR."],"journal":"Proceedings of the National Academy of Sciences of the United States of America","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10377455","id":"10377455","citationCount":550,"stringAuthors":"Warner TD,  Giuliano F,  Vojnovic I,  Bukasa A,  Mitchell JA,  Vane JR."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10377455","resource":"10377455","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis.","authors":["Warner TD"," Giuliano F"," Vojnovic I"," Bukasa A"," Mitchell JA"," Vane JR."],"journal":"Proceedings of the National Academy of Sciences of the United States of America","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10377455","id":"10377455","citationCount":550,"stringAuthors":"Warner TD,  Giuliano F,  Vojnovic I,  Bukasa A,  Mitchell JA,  Vane JR."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10377455","resource":"10377455","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PTGS1","resource":"PTGS1","type":"HGNC_SYMBOL"}]},{"name":"Prostaglandin G/H synthase 2","references":[{"annotatorClassName":"","article":{"title":"Interaction of nonsteroidal anti-inflammatory drugs (NSAID) with Helicobacter pylori in the stomach of humans and experimental animals.","authors":["Brzozowski T"," Konturek PC"," Sliwowski Z"," KwiecieÅ„ S"," Drozdowicz D"," Pawlik M"," Mach K"," Konturek SJ"," Pawlik WW."],"journal":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17033106","id":"17033106","citationCount":18,"stringAuthors":"Brzozowski T,  Konturek PC,  Sliwowski Z,  KwiecieÅ„ S,  Drozdowicz D,  Pawlik M,  Mach K,  Konturek SJ,  Pawlik WW."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17033106","resource":"17033106","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"[Effects of nonsteroidal anti-inflammatory drug celecoxib on expression of cyclooxygenase-2 (COX-2) in ovarian carcinoma cell].","authors":["Wang HJ"," Liu XJ"," Yang KX"," Luo FM"," Lou JY"," Peng ZL."],"journal":"Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17037745","id":"17037745","citationCount":0,"stringAuthors":"Wang HJ,  Liu XJ,  Yang KX,  Luo FM,  Lou JY,  Peng ZL."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17037745","resource":"17037745","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Genetic polymorphisms in the cyclooxygenase-2 gene, use of nonsteroidal anti-inflammatory drugs, and breast cancer risk.","authors":["Shen J"," Gammon MD"," Terry MB"," Teitelbaum SL"," Neugut AI"," Santella RM."],"journal":"Breast cancer research : BCR","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17181859","id":"17181859","citationCount":28,"stringAuthors":"Shen J,  Gammon MD,  Terry MB,  Teitelbaum SL,  Neugut AI,  Santella RM."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17181859","resource":"17181859","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Interaction between cyclooxygenase (COX)-1- and COX-2-products modulates COX-2 expression in the late phase of acute inflammation.","authors":["Nakano M"," Denda N"," Matsumoto M"," Kawamura M"," Kawakubo Y"," Hatanaka K"," Hiramoto Y"," Sato Y"," Noshiro M"," Harada Y."],"journal":"European journal of pharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17258197","id":"17258197","citationCount":5,"stringAuthors":"Nakano M,  Denda N,  Matsumoto M,  Kawamura M,  Kawakubo Y,  Hatanaka K,  Hiramoto Y,  Sato Y,  Noshiro M,  Harada Y."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17258197","resource":"17258197","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Blood levels of long-chain polyunsaturated fatty acids, aspirin, and the risk of colorectal cancer.","authors":["Hall MN"," Campos H"," Li H"," Sesso HD"," Stampfer MJ"," Willett WC"," Ma J."],"journal":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17301265","id":"17301265","citationCount":33,"stringAuthors":"Hall MN,  Campos H,  Li H,  Sesso HD,  Stampfer MJ,  Willett WC,  Ma J."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17301265","resource":"17301265","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"TTD: Therapeutic Target Database.","authors":["Chen X"," Ji ZL"," Chen YZ."],"journal":"Nucleic acids research","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","id":"11752352","citationCount":104,"stringAuthors":"Chen X,  Ji ZL,  Chen YZ."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11752352","resource":"11752352","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PTGS2","resource":"PTGS2","type":"HGNC_SYMBOL"}]},{"name":"Ribosomal protein S6 kinase alpha-3","references":[{"annotatorClassName":"","article":{"title":"Salicylic acid and aspirin inhibit the activity of RSK2 kinase and repress RSK2-dependent transcription of cyclic AMP response element binding protein- and NF-kappa B-responsive genes.","authors":["Stevenson MA"," Zhao MJ"," Asea A"," Coleman CN"," Calderwood SK."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10553090","id":"10553090","citationCount":22,"stringAuthors":"Stevenson MA,  Zhao MJ,  Asea A,  Coleman CN,  Calderwood SK."},"descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10553090","resource":"10553090","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","descriptionByType":"","descriptionByTypeRelation":"","id":0,"link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=RPS6KA3","resource":"RPS6KA3","type":"HGNC_SYMBOL"}]}]}]
\ No newline at end of file