diff --git a/frontend-js/src/main/js/gui/leftPanel/GuiUtils.js b/frontend-js/src/main/js/gui/leftPanel/GuiUtils.js
index df73c3734e9761b481be2eb0bfa912f1c5e08d8e..09fc55fa0769c2beab7a7cb6ced8db7b91a92841 100644
--- a/frontend-js/src/main/js/gui/leftPanel/GuiUtils.js
+++ b/frontend-js/src/main/js/gui/leftPanel/GuiUtils.js
@@ -204,7 +204,7 @@ GuiUtils.prototype.createAnnotationList = function (annotations, options) {
     // var desc = grouppedAnnotations.keys()[i];
     var groupContainer = (inline ? document.createElement("span") : document.createElement("div"));
     var descContainer = (inline ? document.createElement("span") : document.createElement("div"));
-    
+
     var annotatorName = annotatorClass ? annotatorsClassMapping[annotatorClass].getName() : "Annotated by curator";
 
     if (inline) {
diff --git a/frontend-js/src/test/js/gui/leftPanel/ChemicalPanel-test.js b/frontend-js/src/test/js/gui/leftPanel/ChemicalPanel-test.js
index 04fa6933c9db1cd02871535f59f1a8f824e573cf..17aebb8ce74bd80f89dfb07810c0f7f7564cfd05 100644
--- a/frontend-js/src/test/js/gui/leftPanel/ChemicalPanel-test.js
+++ b/frontend-js/src/test/js/gui/leftPanel/ChemicalPanel-test.js
@@ -109,35 +109,36 @@ describe('ChemicalPanel', function () {
   });
 
   it('on searchResults changed', function () {
-    var map = helper.createCustomMap();
-    map.getModel().setId(15781);
-    var chemicalDbOverlay = helper.createChemicalDbOverlay(map);
-
-    new ChemicalPanel({
-      element: testDiv,
-      customMap: map
-    });
+    return ServerConnector.getProject().then(function (project) {
+      var map = helper.createCustomMap(project);
+      var chemicalDbOverlay = helper.createChemicalDbOverlay(map);
+      new ChemicalPanel({
+        element: testDiv,
+        customMap: map
+      });
 
-    return chemicalDbOverlay.searchByQuery("rotenone").then(function () {
-      assert.equal(logger.getWarnings().length, 1);
+      return chemicalDbOverlay.searchByQuery("rotenone");
+    }).then(function () {
+      assert.equal(logger.getWarnings().length, 0);
       assert.ok(testDiv.innerHTML.indexOf("marker/mechanism") >= 0);
     });
   });
 
   it('searchByQuery', function () {
-    var map = helper.createCustomMap();
-    map.getModel().setId(15781);
-    helper.createChemicalDbOverlay(map);
+    return ServerConnector.getProject().then(function (project) {
+      var map = helper.createCustomMap(project);
+      helper.createChemicalDbOverlay(map);
 
-    var panel = new ChemicalPanel({
-      element: testDiv,
-      customMap: map
-    });
+      var panel = new ChemicalPanel({
+        element: testDiv,
+        customMap: map
+      });
 
-    panel.getControlElement(PanelControlElementType.SEARCH_INPUT).value = "rotenone";
+      panel.getControlElement(PanelControlElementType.SEARCH_INPUT).value = "rotenone";
 
-    return panel.searchByQuery().then(function () {
-      assert.equal(logger.getWarnings().length, 1);
+      return panel.searchByQuery();
+    }).then(function () {
+      assert.equal(logger.getWarnings().length, 0);
       assert.ok(testDiv.innerHTML.indexOf("Rotenone ") >= 0);
     });
   });
@@ -178,4 +179,5 @@ describe('ChemicalPanel', function () {
   });
 
 
-});
+})
+;
diff --git a/frontend-js/testFiles/apiCalls/configuration/token=MOCK_TOKEN_ID& b/frontend-js/testFiles/apiCalls/configuration/token=MOCK_TOKEN_ID&
index 8e613c6930b2c03413c96fb8e9e5b3070227597f..b20401250fa29253a276aa355b8c48f3a2b55d35 100644
--- a/frontend-js/testFiles/apiCalls/configuration/token=MOCK_TOKEN_ID&
+++ b/frontend-js/testFiles/apiCalls/configuration/token=MOCK_TOKEN_ID&
@@ -1 +1 @@
-{"modelFormats":[{"handler":"lcsb.mapviewer.converter.model.celldesigner.CellDesignerXmlParser","extension":"xml","name":"CellDesigner SBML"},{"handler":"lcsb.mapviewer.converter.model.sbgnml.SbgnmlXmlConverter","extension":"sbgn","name":"SBGN-ML"},{"handler":"lcsb.mapviewer.converter.model.sbml.SbmlParser","extension":"xml","name":"SBML"}],"elementTypes":[{"name":"Degraded","className":"lcsb.mapviewer.model.map.species.Degraded","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"name":"Compartment","className":"lcsb.mapviewer.model.map.compartment.LeftSquareCompartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"name":"Protein","className":"lcsb.mapviewer.model.map.species.IonChannelProtein","parentClass":"lcsb.mapviewer.model.map.species.Protein"},{"name":"Compartment","className":"lcsb.mapviewer.model.map.compartment.TopSquareCompartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"name":"Ion","className":"lcsb.mapviewer.model.map.species.Ion","parentClass":"lcsb.mapviewer.model.map.species.Chemical"},{"name":"Species","className":"lcsb.mapviewer.model.map.species.Species","parentClass":"lcsb.mapviewer.model.map.species.Element"},{"name":"Compartment","className":"lcsb.mapviewer.model.map.compartment.RightSquareCompartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"name":"Drug","className":"lcsb.mapviewer.model.map.species.Drug","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"name":"Protein","className":"lcsb.mapviewer.model.map.species.Protein","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"name":"Protein","className":"lcsb.mapviewer.model.map.species.TruncatedProtein","parentClass":"lcsb.mapviewer.model.map.species.Protein"},{"name":"Compartment","className":"lcsb.mapviewer.model.map.compartment.PathwayCompartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"name":"Compartment","className":"lcsb.mapviewer.model.map.compartment.BottomSquareCompartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"name":"RNA","className":"lcsb.mapviewer.model.map.species.Rna","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"name":"Chemical","className":"lcsb.mapviewer.model.map.species.Chemical","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"name":"Compartment","className":"lcsb.mapviewer.model.map.compartment.Compartment","parentClass":"lcsb.mapviewer.model.map.species.Element"},{"name":"Compartment","className":"lcsb.mapviewer.model.map.compartment.OvalCompartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"name":"Compartment","className":"lcsb.mapviewer.model.map.compartment.SquareCompartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"name":"Unknown","className":"lcsb.mapviewer.model.map.species.Unknown","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"name":"Element","className":"lcsb.mapviewer.model.map.species.Element","parentClass":"lcsb.mapviewer.model.map.BioEntity"},{"name":"Phenotype","className":"lcsb.mapviewer.model.map.species.Phenotype","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"name":"Complex","className":"lcsb.mapviewer.model.map.species.Complex","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"name":"Antisense RNA","className":"lcsb.mapviewer.model.map.species.AntisenseRna","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"name":"Protein","className":"lcsb.mapviewer.model.map.species.ReceptorProtein","parentClass":"lcsb.mapviewer.model.map.species.Protein"},{"name":"Simple molecule","className":"lcsb.mapviewer.model.map.species.SimpleMolecule","parentClass":"lcsb.mapviewer.model.map.species.Chemical"},{"name":"Protein","className":"lcsb.mapviewer.model.map.species.GenericProtein","parentClass":"lcsb.mapviewer.model.map.species.Protein"},{"name":"Gene","className":"lcsb.mapviewer.model.map.species.Gene","parentClass":"lcsb.mapviewer.model.map.species.Species"}],"modificationStateTypes":{"PHOSPHORYLATED":{"commonName":"phosphorylated","abbreviation":"P"},"METHYLATED":{"commonName":"methylated","abbreviation":"Me"},"PALMYTOYLATED":{"commonName":"palmytoylated","abbreviation":"Pa"},"ACETYLATED":{"commonName":"acetylated","abbreviation":"Ac"},"SULFATED":{"commonName":"sulfated","abbreviation":"S"},"GLYCOSYLATED":{"commonName":"glycosylated","abbreviation":"G"},"PRENYLATED":{"commonName":"prenylated","abbreviation":"Pr"},"UBIQUITINATED":{"commonName":"ubiquitinated","abbreviation":"Ub"},"PROTONATED":{"commonName":"protonated","abbreviation":"H"},"HYDROXYLATED":{"commonName":"hydroxylated","abbreviation":"OH"},"MYRISTOYLATED":{"commonName":"myristoylated","abbreviation":"My"},"UNKNOWN":{"commonName":"unknown","abbreviation":"?"},"EMPTY":{"commonName":"empty","abbreviation":""},"DONT_CARE":{"commonName":"don't care","abbreviation":"*"}},"imageFormats":[{"handler":"lcsb.mapviewer.converter.graphics.PngImageGenerator","extension":"png","name":"PNG image"},{"handler":"lcsb.mapviewer.converter.graphics.PdfImageGenerator","extension":"pdf","name":"PDF"},{"handler":"lcsb.mapviewer.converter.graphics.SvgImageGenerator","extension":"svg","name":"SVG image"}],"plugins":[],"annotators":[{"name":"Biocompendium","className":"lcsb.mapviewer.annotation.services.annotators.BiocompendiumAnnotator","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"url":"http://biocompendium.embl.de/"},{"name":"Chebi","className":"lcsb.mapviewer.annotation.services.annotators.ChebiAnnotator","elementClassNames":["lcsb.mapviewer.model.map.species.Chemical"],"url":"http://www.ebi.ac.uk/chebi/"},{"name":"Uniprot","className":"lcsb.mapviewer.annotation.services.annotators.UniprotAnnotator","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"url":"http://www.uniprot.org/"},{"name":"Gene Ontology","className":"lcsb.mapviewer.annotation.services.annotators.GoAnnotator","elementClassNames":["lcsb.mapviewer.model.map.species.Phenotype","lcsb.mapviewer.model.map.compartment.Compartment","lcsb.mapviewer.model.map.species.Complex"],"url":"http://amigo.geneontology.org/amigo"},{"name":"HGNC","className":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Rna","lcsb.mapviewer.model.map.species.Gene"],"url":"http://www.genenames.org"},{"name":"Protein Data Bank","className":"lcsb.mapviewer.annotation.services.annotators.PdbAnnotator","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Rna","lcsb.mapviewer.model.map.species.Gene"],"url":"http://www.pdbe.org/"},{"name":"Recon annotator","className":"lcsb.mapviewer.annotation.services.annotators.ReconAnnotator","elementClassNames":["lcsb.mapviewer.model.map.species.Chemical","lcsb.mapviewer.model.map.reaction.Reaction"],"url":"http://humanmetabolism.org/"},{"name":"Entrez Gene","className":"lcsb.mapviewer.annotation.services.annotators.EntrezAnnotator","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Rna","lcsb.mapviewer.model.map.species.Gene"],"url":"http://www.ncbi.nlm.nih.gov/gene"},{"name":"Ensembl","className":"lcsb.mapviewer.annotation.services.annotators.EnsemblAnnotator","elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Rna","lcsb.mapviewer.model.map.species.Gene"],"url":"www.ensembl.org"}],"buildDate":"            15/02/2018 14:03","reactionTypes":[{"name":"Catalysis","className":"lcsb.mapviewer.model.map.reaction.type.CatalysisReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Unknown positive influence","className":"lcsb.mapviewer.model.map.reaction.type.UnknownPositiveInfluenceReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Generic Reaction","className":"lcsb.mapviewer.model.map.reaction.Reaction","parentClass":"lcsb.mapviewer.model.map.BioEntity"},{"name":"Known transition omitted","className":"lcsb.mapviewer.model.map.reaction.type.KnownTransitionOmittedReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Reduced modulation","className":"lcsb.mapviewer.model.map.reaction.type.ReducedModulationReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Translation","className":"lcsb.mapviewer.model.map.reaction.type.TranslationReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Heterodimer association","className":"lcsb.mapviewer.model.map.reaction.type.HeterodimerAssociationReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Transcription","className":"lcsb.mapviewer.model.map.reaction.type.TranscriptionReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Unknown reduced trigger","className":"lcsb.mapviewer.model.map.reaction.type.UnknownReducedTriggerReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Unknown negative influence","className":"lcsb.mapviewer.model.map.reaction.type.UnknownNegativeInfluenceReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Truncation","className":"lcsb.mapviewer.model.map.reaction.type.TruncationReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Transport","className":"lcsb.mapviewer.model.map.reaction.type.TransportReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Unknown catalysis","className":"lcsb.mapviewer.model.map.reaction.type.UnknownCatalysisReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Reduced trigger","className":"lcsb.mapviewer.model.map.reaction.type.ReducedTriggerReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"State transition","className":"lcsb.mapviewer.model.map.reaction.type.StateTransitionReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Physical stimulation","className":"lcsb.mapviewer.model.map.reaction.type.PhysicalStimulationReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Boolean logic gate","className":"lcsb.mapviewer.model.map.reaction.type.BooleanLogicGateReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Dissociation","className":"lcsb.mapviewer.model.map.reaction.type.DissociationReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Inhibition","className":"lcsb.mapviewer.model.map.reaction.type.InhibitionReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Reduced physical stimulation","className":"lcsb.mapviewer.model.map.reaction.type.ReducedPhysicalStimulationReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Negative influence","className":"lcsb.mapviewer.model.map.reaction.type.NegativeInfluenceReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Unknown inhibition","className":"lcsb.mapviewer.model.map.reaction.type.UnknownInhibitionReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Modulation","className":"lcsb.mapviewer.model.map.reaction.type.ModulationReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Positive influence","className":"lcsb.mapviewer.model.map.reaction.type.PositiveInfluenceReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Unknown reduced physical stimulation","className":"lcsb.mapviewer.model.map.reaction.type.UnknownReducedPhysicalStimulationReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Unknown reduced modulation","className":"lcsb.mapviewer.model.map.reaction.type.UnknownReducedModulationReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Unknown transition","className":"lcsb.mapviewer.model.map.reaction.type.UnknownTransitionReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Trigger","className":"lcsb.mapviewer.model.map.reaction.type.TriggerReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"}],"version":"12.0.0","mapTypes":[{"name":"Downstream targets","id":"DOWNSTREAM_TARGETS"},{"name":"Pathway","id":"PATHWAY"},{"name":"Unknown","id":"UNKNOWN"}],"miriamTypes":{"CHEMBL_TARGET":{"commonName":"ChEMBL target","uris":["urn:miriam:chembl.target"],"homepage":"https://www.ebi.ac.uk/chembldb/","registryIdentifier":"MIR:00000085"},"UNIPROT":{"commonName":"Uniprot","uris":["urn:miriam:uniprot"],"homepage":"http://www.uniprot.org/","registryIdentifier":"MIR:00000005"},"MI_R_BASE_MATURE_SEQUENCE":{"commonName":"miRBase Mature Sequence Database","uris":["urn:miriam:mirbase.mature"],"homepage":"http://www.mirbase.org/","registryIdentifier":"MIR:00000235"},"PFAM":{"commonName":"Protein Family Database","uris":["urn:miriam:pfam"],"homepage":"http://pfam.xfam.org//","registryIdentifier":"MIR:00000028"},"ENSEMBL_PLANTS":{"commonName":"Ensembl Plants","uris":["urn:miriam:ensembl.plant"],"homepage":"http://plants.ensembl.org/","registryIdentifier":"MIR:00000205"},"WIKIPEDIA":{"commonName":"Wikipedia (English)","uris":["urn:miriam:wikipedia.en"],"homepage":"http://en.wikipedia.org/wiki/Main_Page","registryIdentifier":"MIR:00000384"},"CHEBI":{"commonName":"Chebi","uris":["urn:miriam:obo.chebi","urn:miriam:chebi"],"homepage":"http://www.ebi.ac.uk/chebi/","registryIdentifier":"MIR:00000002"},"WIKIDATA":{"commonName":"Wikidata","uris":["urn:miriam:wikidata"],"homepage":"https://www.wikidata.org/","registryIdentifier":"MIR:00000549"},"REACTOME":{"commonName":"Reactome","uris":["urn:miriam:reactome"],"homepage":"http://www.reactome.org/","registryIdentifier":"MIR:00000018"},"EC":{"commonName":"Enzyme Nomenclature","uris":["urn:miriam:ec-code"],"homepage":"http://www.enzyme-database.org/","registryIdentifier":"MIR:00000004"},"DOI":{"commonName":"Digital Object Identifier","uris":["urn:miriam:doi"],"homepage":"http://www.doi.org/","registryIdentifier":"MIR:00000019"},"UNIPROT_ISOFORM":{"commonName":"UniProt Isoform","uris":["urn:miriam:uniprot.isoform"],"homepage":"http://www.uniprot.org/","registryIdentifier":"MIR:00000388"},"OMIM":{"commonName":"Online Mendelian Inheritance in Man","uris":["urn:miriam:omim"],"homepage":"http://omim.org/","registryIdentifier":"MIR:00000016"},"DRUGBANK_TARGET_V4":{"commonName":"DrugBank Target v4","uris":["urn:miriam:drugbankv4.target"],"homepage":"http://www.drugbank.ca/targets","registryIdentifier":"MIR:00000528"},"MIR_TAR_BASE_MATURE_SEQUENCE":{"commonName":"miRTarBase Mature Sequence Database","uris":["urn:miriam:mirtarbase"],"homepage":"http://mirtarbase.mbc.nctu.edu.tw/","registryIdentifier":"MIR:00100739"},"CHEMBL_COMPOUND":{"commonName":"ChEMBL","uris":["urn:miriam:chembl.compound"],"homepage":"https://www.ebi.ac.uk/chembldb/","registryIdentifier":"MIR:00000084"},"KEGG_PATHWAY":{"commonName":"Kegg Pathway","uris":["urn:miriam:kegg.pathway"],"homepage":"http://www.genome.jp/kegg/pathway.html","registryIdentifier":"MIR:00000012"},"CAS":{"commonName":"Chemical Abstracts Service","uris":["urn:miriam:cas"],"homepage":"http://commonchemistry.org","registryIdentifier":"MIR:00000237"},"REFSEQ":{"commonName":"RefSeq","uris":["urn:miriam:refseq"],"homepage":"http://www.ncbi.nlm.nih.gov/projects/RefSeq/","registryIdentifier":"MIR:00000039"},"WORM_BASE":{"commonName":"WormBase","uris":["urn:miriam:wormbase"],"homepage":"http://wormbase.bio2rdf.org/fct","registryIdentifier":"MIR:00000027"},"MI_R_BASE_SEQUENCE":{"commonName":"miRBase Sequence Database","uris":["urn:miriam:mirbase"],"homepage":"http://www.mirbase.org/","registryIdentifier":"MIR:00000078"},"TAIR_LOCUS":{"commonName":"TAIR Locus","uris":["urn:miriam:tair.locus"],"homepage":"http://arabidopsis.org/index.jsp","registryIdentifier":"MIR:00000050"},"PHARM":{"commonName":"PharmGKB Pathways","uris":["urn:miriam:pharmgkb.pathways"],"homepage":"http://www.pharmgkb.org/","registryIdentifier":"MIR:00000089"},"PDB":{"commonName":"Protein Data Bank","uris":["urn:miriam:pdb"],"homepage":"http://www.pdbe.org/","registryIdentifier":"MIR:00000020"},"PANTHER":{"commonName":"PANTHER Family","uris":["urn:miriam:panther.family","urn:miriam:panther"],"homepage":"http://www.pantherdb.org/","registryIdentifier":"MIR:00000060"},"TAXONOMY":{"commonName":"Taxonomy","uris":["urn:miriam:taxonomy"],"homepage":"http://www.ncbi.nlm.nih.gov/taxonomy/","registryIdentifier":"MIR:00000006"},"UNIGENE":{"commonName":"UniGene","uris":["urn:miriam:unigene"],"homepage":"http://www.ncbi.nlm.nih.gov/unigene","registryIdentifier":"MIR:00000346"},"HGNC":{"commonName":"HGNC","uris":["urn:miriam:hgnc"],"homepage":"http://www.genenames.org","registryIdentifier":"MIR:00000080"},"HGNC_SYMBOL":{"commonName":"HGNC Symbol","uris":["urn:miriam:hgnc.symbol"],"homepage":"http://www.genenames.org","registryIdentifier":"MIR:00000362"},"COG":{"commonName":"Clusters of Orthologous Groups","uris":["urn:miriam:cogs"],"homepage":"https://www.ncbi.nlm.nih.gov/COG/","registryIdentifier":"MIR:00000296"},"WIKIPATHWAYS":{"commonName":"WikiPathways","uris":["urn:miriam:wikipathways"],"homepage":"http://www.wikipathways.org/","registryIdentifier":"MIR:00000076"},"HMDB":{"commonName":"HMDB","uris":["urn:miriam:hmdb"],"homepage":"http://www.hmdb.ca/","registryIdentifier":"MIR:00000051"},"CHEMSPIDER":{"commonName":"ChemSpider","uris":["urn:miriam:chemspider"],"homepage":"http://www.chemspider.com//","registryIdentifier":"MIR:00000138"},"ENSEMBL":{"commonName":"Ensembl","uris":["urn:miriam:ensembl"],"homepage":"www.ensembl.org","registryIdentifier":"MIR:00000003"},"GO":{"commonName":"Gene Ontology","uris":["urn:miriam:obo.go","urn:miriam:go"],"homepage":"http://amigo.geneontology.org/amigo","registryIdentifier":"MIR:00000022"},"KEGG_REACTION":{"commonName":"Kegg Reaction","uris":["urn:miriam:kegg.reaction"],"homepage":"http://www.genome.jp/kegg/reaction/","registryIdentifier":"MIR:00000014"},"KEGG_ORTHOLOGY":{"commonName":"KEGG Orthology","uris":["urn:miriam:kegg.orthology"],"homepage":"http://www.genome.jp/kegg/ko.html","registryIdentifier":"MIR:00000116"},"PUBCHEM":{"commonName":"PubChem-compound","uris":["urn:miriam:pubchem.compound"],"homepage":"http://pubchem.ncbi.nlm.nih.gov/","registryIdentifier":"MIR:00000034"},"MESH_2012":{"commonName":"MeSH 2012","uris":["urn:miriam:mesh.2012","urn:miriam:mesh"],"homepage":"http://www.nlm.nih.gov/mesh/","registryIdentifier":"MIR:00000270"},"MGD":{"commonName":"Mouse Genome Database","uris":["urn:miriam:mgd"],"homepage":"http://www.informatics.jax.org/","registryIdentifier":"MIR:00000037"},"ENTREZ":{"commonName":"Entrez Gene","uris":["urn:miriam:ncbigene","urn:miriam:entrez.gene"],"homepage":"http://www.ncbi.nlm.nih.gov/gene","registryIdentifier":"MIR:00000069"},"PUBCHEM_SUBSTANCE":{"commonName":"PubChem-substance","uris":["urn:miriam:pubchem.substance"],"homepage":"http://pubchem.ncbi.nlm.nih.gov/","registryIdentifier":"MIR:00000033"},"CCDS":{"commonName":"Consensus CDS","uris":["urn:miriam:ccds"],"homepage":"http://www.ncbi.nlm.nih.gov/CCDS/","registryIdentifier":"MIR:00000375"},"KEGG_GENES":{"commonName":"Kegg Genes","uris":["urn:miriam:kegg.genes","urn:miriam:kegg.genes:hsa"],"homepage":"http://www.genome.jp/kegg/genes.html","registryIdentifier":"MIR:00000070"},"TOXICOGENOMIC_CHEMICAL":{"commonName":"Toxicogenomic Chemical","uris":["urn:miriam:ctd.chemical"],"homepage":"http://ctdbase.org/","registryIdentifier":"MIR:00000098"},"SGD":{"commonName":"Saccharomyces Genome Database","uris":["urn:miriam:sgd"],"homepage":"http://www.yeastgenome.org/","registryIdentifier":"MIR:00000023"},"KEGG_COMPOUND":{"commonName":"Kegg Compound","uris":["urn:miriam:kegg.compound"],"homepage":"http://www.genome.jp/kegg/ligand.html","registryIdentifier":"MIR:00000013"},"INTERPRO":{"commonName":"InterPro","uris":["urn:miriam:interpro"],"homepage":"http://www.ebi.ac.uk/interpro/","registryIdentifier":"MIR:00000011"},"UNKNOWN":{"commonName":"Unknown","uris":[],"homepage":null,"registryIdentifier":null},"DRUGBANK":{"commonName":"DrugBank","uris":["urn:miriam:drugbank"],"homepage":"http://www.drugbank.ca/","registryIdentifier":"MIR:00000102"},"PUBMED":{"commonName":"PubMed","uris":["urn:miriam:pubmed"],"homepage":"http://www.ncbi.nlm.nih.gov/PubMed/","registryIdentifier":"MIR:00000015"}},"unitTypes":[{"name":"ampere","id":"AMPERE"},{"name":"becquerel","id":"BECQUEREL"},{"name":"candela","id":"CANDELA"},{"name":"coulumb","id":"COULUMB"},{"name":"dimensionless","id":"DIMENSIONLESS"},{"name":"farad","id":"FARAD"},{"name":"gram","id":"GRAM"},{"name":"gray","id":"GRAY"},{"name":"henry","id":"HENRY"},{"name":"hertz","id":"HERTZ"},{"name":"item","id":"ITEM"},{"name":"joule","id":"JOULE"},{"name":"katal","id":"KATAL"},{"name":"kelvin","id":"KELVIN"},{"name":"kilogram","id":"KILOGRAM"},{"name":"litre","id":"LITRE"},{"name":"lumen","id":"LUMEN"},{"name":"lux","id":"LUX"},{"name":"metre","id":"METRE"},{"name":"mole","id":"MOLE"},{"name":"newton","id":"NEWTON"},{"name":"ohm","id":"OHM"},{"name":"pascal","id":"PASCAL"},{"name":"radian","id":"RADIAN"},{"name":"second","id":"SECOND"},{"name":"siemens","id":"SIEMENS"},{"name":"sievert","id":"SIEVERT"},{"name":"steradian","id":"STERADIAN"},{"name":"tesla","id":"TESLA"},{"name":"volt","id":"VOLT"},{"name":"watt","id":"WATT"},{"name":"weber","id":"WEBER"}],"options":[{"idObject":9,"type":"EMAIL_ADDRESS","value":"gawron13@o2.pl","valueType":"EMAIL","commonName":"E-mail address"},{"idObject":10,"type":"EMAIL_LOGIN","value":"gawron13","valueType":"STRING","commonName":"E-mail server login"},{"idObject":11,"type":"EMAIL_PASSWORD","value":"k13liszk!","valueType":"PASSWORD","commonName":"E-mail server password"},{"idObject":13,"type":"EMAIL_IMAP_SERVER","value":"your.imap.domain.com","valueType":"STRING","commonName":"IMAP server"},{"idObject":12,"type":"EMAIL_SMTP_SERVER","value":"poczta.o2.pl","valueType":"STRING","commonName":"SMTP server"},{"idObject":14,"type":"EMAIL_SMTP_PORT","value":"25","valueType":"INTEGER","commonName":"SMTP port"},{"idObject":6,"type":"DEFAULT_MAP","value":"sample","valueType":"STRING","commonName":"Default Project Id"},{"idObject":4,"type":"LOGO_IMG","value":"udl.png","valueType":"URL","commonName":"Logo icon"},{"idObject":3,"type":"LOGO_LINK","value":"http://wwwen.uni.lu/","valueType":"URL","commonName":"Logo link (after click)"},{"idObject":7,"type":"SEARCH_DISTANCE","value":"10","valueType":"DOUBLE","commonName":"Max distance for clicking on element (px)"},{"idObject":1,"type":"REQUEST_ACCOUNT_EMAIL","value":"your.email@domain.com","valueType":"EMAIL","commonName":"Email used for requesting an account"},{"idObject":8,"type":"SEARCH_RESULT_NUMBER","value":"100","valueType":"INTEGER","commonName":"Max number of results in search box. "},{"idObject":2,"type":"GOOGLE_ANALYTICS_IDENTIFIER","value":"","valueType":"STRING","commonName":"Google Analytics tracking ID used for statistics"},{"idObject":5,"type":"LOGO_TEXT","value":"University of Luxembourg","valueType":"STRING","commonName":"Logo description"},{"idObject":56,"type":"X_FRAME_DOMAIN","value":"http://localhost:8080/","valueType":"URL","commonName":"Domain allowed to connect via x-frame technology"},{"idObject":131,"type":"BIG_FILE_STORAGE_DIR","value":"minerva-big/","valueType":"STRING","commonName":"Path to store big files"},{"idObject":138,"type":"LEGEND_FILE_1","value":"resources/images/legend_a.png","valueType":"URL","commonName":"Legend 1 image file"},{"idObject":139,"type":"LEGEND_FILE_2","value":"resources/images/legend_b.png","valueType":"URL","commonName":"Legend 2 image file"},{"idObject":140,"type":"LEGEND_FILE_3","value":"resources/images/legend_c.png","valueType":"URL","commonName":"Legend 3 image file"},{"idObject":141,"type":"LEGEND_FILE_4","value":"resources/images/legend_d.png","valueType":"URL","commonName":"Legend 4 image file"},{"idObject":142,"type":"USER_MANUAL_FILE","value":"resources/other/user_guide.pdf","valueType":"URL","commonName":"User manual file"},{"idObject":205,"type":"MIN_COLOR_VAL","value":"FF0000","valueType":"COLOR","commonName":"Overlay color for negative values"},{"idObject":206,"type":"MAX_COLOR_VAL","value":"fbff00","valueType":"COLOR","commonName":"Overlay color for postive values"},{"idObject":218,"type":"SIMPLE_COLOR_VAL","value":"00ff40","valueType":"COLOR","commonName":"Overlay color when no values are defined"},{"idObject":239,"type":"NEUTRAL_COLOR_VAL","value":"0400ff","valueType":"COLOR","commonName":"Overlay color for value=0"},{"idObject":252,"type":"OVERLAY_OPACITY","value":"0.8","valueType":"DOUBLE","commonName":"Opacity used when drwaing data overlays (value between 0.0-1.0)"},{"idObject":253,"type":"REQUEST_ACCOUNT_DEFAULT_CONTENT","value":"Dear Diseas map team,\n\nI would like to request for an account.\n\nKind regards","valueType":"TEXT","commonName":"Email content used for requesting an account"},{"idObject":266,"type":"DEFAULT_VIEW_PROJECT","value":"true","valueType":"BOOLEAN","commonName":"Default user privilege for: View project"},{"idObject":267,"type":"DEFAULT_EDIT_COMMENTS_PROJECT","value":"false","valueType":"BOOLEAN","commonName":"Default user privilege for: Manage comments"},{"idObject":268,"type":"DEFAULT_LAYOUT_MANAGEMENT","value":"false","valueType":"BOOLEAN","commonName":"Default user privilege for: Manage layouts"}],"privilegeTypes":{"VIEW_PROJECT":{"commonName":"View project","valueType":"boolean","objectType":"Project"},"LAYOUT_MANAGEMENT":{"commonName":"Manage layouts","valueType":"boolean","objectType":"Project"},"PROJECT_MANAGEMENT":{"commonName":"Map management","valueType":"boolean","objectType":null},"CUSTOM_LAYOUTS":{"commonName":"Custom layouts","valueType":"int","objectType":null},"ADD_MAP":{"commonName":"Add project","valueType":"boolean","objectType":null},"LAYOUT_VIEW":{"commonName":"View layout","valueType":"boolean","objectType":"Layout"},"MANAGE_GENOMES":{"commonName":"Manage genomes","valueType":"boolean","objectType":null},"EDIT_COMMENTS_PROJECT":{"commonName":"Manage comments","valueType":"boolean","objectType":"Project"},"CONFIGURATION_MANAGE":{"commonName":"Manage configuration","valueType":"boolean","objectType":null},"USER_MANAGEMENT":{"commonName":"User management","valueType":"boolean","objectType":null}},"overlayTypes":[{"name":"GENERIC"},{"name":"GENETIC_VARIANT"}]}
\ No newline at end of file
+{"modelFormats":[{"handler":"lcsb.mapviewer.converter.model.celldesigner.CellDesignerXmlParser","extension":"xml","name":"CellDesigner SBML"},{"handler":"lcsb.mapviewer.converter.model.sbgnml.SbgnmlXmlConverter","extension":"sbgn","name":"SBGN-ML"},{"handler":"lcsb.mapviewer.converter.model.sbml.SbmlParser","extension":"xml","name":"SBML"}],"elementTypes":[{"name":"Degraded","className":"lcsb.mapviewer.model.map.species.Degraded","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"name":"Compartment","className":"lcsb.mapviewer.model.map.compartment.LeftSquareCompartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"name":"Protein","className":"lcsb.mapviewer.model.map.species.IonChannelProtein","parentClass":"lcsb.mapviewer.model.map.species.Protein"},{"name":"Compartment","className":"lcsb.mapviewer.model.map.compartment.TopSquareCompartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"name":"Ion","className":"lcsb.mapviewer.model.map.species.Ion","parentClass":"lcsb.mapviewer.model.map.species.Chemical"},{"name":"Species","className":"lcsb.mapviewer.model.map.species.Species","parentClass":"lcsb.mapviewer.model.map.species.Element"},{"name":"Compartment","className":"lcsb.mapviewer.model.map.compartment.RightSquareCompartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"name":"Drug","className":"lcsb.mapviewer.model.map.species.Drug","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"name":"Protein","className":"lcsb.mapviewer.model.map.species.Protein","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"name":"Protein","className":"lcsb.mapviewer.model.map.species.TruncatedProtein","parentClass":"lcsb.mapviewer.model.map.species.Protein"},{"name":"Compartment","className":"lcsb.mapviewer.model.map.compartment.PathwayCompartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"name":"Compartment","className":"lcsb.mapviewer.model.map.compartment.BottomSquareCompartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"name":"RNA","className":"lcsb.mapviewer.model.map.species.Rna","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"name":"Chemical","className":"lcsb.mapviewer.model.map.species.Chemical","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"name":"Compartment","className":"lcsb.mapviewer.model.map.compartment.Compartment","parentClass":"lcsb.mapviewer.model.map.species.Element"},{"name":"Compartment","className":"lcsb.mapviewer.model.map.compartment.OvalCompartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"name":"Compartment","className":"lcsb.mapviewer.model.map.compartment.SquareCompartment","parentClass":"lcsb.mapviewer.model.map.compartment.Compartment"},{"name":"Unknown","className":"lcsb.mapviewer.model.map.species.Unknown","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"name":"Element","className":"lcsb.mapviewer.model.map.species.Element","parentClass":"lcsb.mapviewer.model.map.BioEntity"},{"name":"Phenotype","className":"lcsb.mapviewer.model.map.species.Phenotype","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"name":"Complex","className":"lcsb.mapviewer.model.map.species.Complex","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"name":"Antisense RNA","className":"lcsb.mapviewer.model.map.species.AntisenseRna","parentClass":"lcsb.mapviewer.model.map.species.Species"},{"name":"Protein","className":"lcsb.mapviewer.model.map.species.ReceptorProtein","parentClass":"lcsb.mapviewer.model.map.species.Protein"},{"name":"Simple molecule","className":"lcsb.mapviewer.model.map.species.SimpleMolecule","parentClass":"lcsb.mapviewer.model.map.species.Chemical"},{"name":"Protein","className":"lcsb.mapviewer.model.map.species.GenericProtein","parentClass":"lcsb.mapviewer.model.map.species.Protein"},{"name":"Gene","className":"lcsb.mapviewer.model.map.species.Gene","parentClass":"lcsb.mapviewer.model.map.species.Species"}],"modificationStateTypes":{"PHOSPHORYLATED":{"commonName":"phosphorylated","abbreviation":"P"},"METHYLATED":{"commonName":"methylated","abbreviation":"Me"},"PALMYTOYLATED":{"commonName":"palmytoylated","abbreviation":"Pa"},"ACETYLATED":{"commonName":"acetylated","abbreviation":"Ac"},"SULFATED":{"commonName":"sulfated","abbreviation":"S"},"GLYCOSYLATED":{"commonName":"glycosylated","abbreviation":"G"},"PRENYLATED":{"commonName":"prenylated","abbreviation":"Pr"},"UBIQUITINATED":{"commonName":"ubiquitinated","abbreviation":"Ub"},"PROTONATED":{"commonName":"protonated","abbreviation":"H"},"HYDROXYLATED":{"commonName":"hydroxylated","abbreviation":"OH"},"MYRISTOYLATED":{"commonName":"myristoylated","abbreviation":"My"},"UNKNOWN":{"commonName":"unknown","abbreviation":"?"},"EMPTY":{"commonName":"empty","abbreviation":""},"DONT_CARE":{"commonName":"don't care","abbreviation":"*"}},"imageFormats":[{"handler":"lcsb.mapviewer.converter.graphics.PngImageGenerator","extension":"png","name":"PNG image"},{"handler":"lcsb.mapviewer.converter.graphics.PdfImageGenerator","extension":"pdf","name":"PDF"},{"handler":"lcsb.mapviewer.converter.graphics.SvgImageGenerator","extension":"svg","name":"SVG image"}],"plugins":[],"annotators":[{"name":"BRENDA","description":"","className":"lcsb.mapviewer.annotation.services.annotators.BrendaAnnotator","parametersDefinitions":[],"elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"url":"http://www.brenda-enzymes.org"},{"name":"Biocompendium","description":"","className":"lcsb.mapviewer.annotation.services.annotators.BiocompendiumAnnotator","parametersDefinitions":[],"elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"url":"http://biocompendium.embl.de/"},{"name":"CAZy","description":"","className":"lcsb.mapviewer.annotation.services.annotators.CazyAnnotator","parametersDefinitions":[],"elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"url":"http://commonchemistry.org"},{"name":"Chebi","description":"","className":"lcsb.mapviewer.annotation.services.annotators.ChebiAnnotator","parametersDefinitions":[],"elementClassNames":["lcsb.mapviewer.model.map.species.Chemical"],"url":"http://www.ebi.ac.uk/chebi/"},{"name":"Uniprot","description":"","className":"lcsb.mapviewer.annotation.services.annotators.UniprotAnnotator","parametersDefinitions":[],"elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"url":"http://www.uniprot.org/"},{"name":"Gene Ontology","description":"","className":"lcsb.mapviewer.annotation.services.annotators.GoAnnotator","parametersDefinitions":[],"elementClassNames":["lcsb.mapviewer.model.map.species.Phenotype","lcsb.mapviewer.model.map.compartment.Compartment","lcsb.mapviewer.model.map.species.Complex"],"url":"http://amigo.geneontology.org/amigo"},{"name":"HGNC","description":"","className":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator","parametersDefinitions":[],"elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Rna","lcsb.mapviewer.model.map.species.Gene"],"url":"http://www.genenames.org"},{"name":"KEGG","description":"Annotations extracted from KEGG ENZYME Database based on species EC numbers. Annotation include relevant publications and homologous genes for given EC numbers.","className":"lcsb.mapviewer.annotation.services.annotators.KeggAnnotator","parametersDefinitions":[{"name":"KEGG organism identifier","description":"Space-delimited list of organisms codes for which homologous genes (GENE section in the KEGG enzyme record) should be imported. Currently only ATH (Arabidopsis Thaliana) is supported.","type":"java.lang.String"}],"elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"url":"http://www.genome.jp/kegg/"},{"name":"Protein Data Bank","description":"","className":"lcsb.mapviewer.annotation.services.annotators.PdbAnnotator","parametersDefinitions":[],"elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Rna","lcsb.mapviewer.model.map.species.Gene"],"url":"http://www.pdbe.org/"},{"name":"Recon annotator","description":"","className":"lcsb.mapviewer.annotation.services.annotators.ReconAnnotator","parametersDefinitions":[],"elementClassNames":["lcsb.mapviewer.model.map.species.Chemical","lcsb.mapviewer.model.map.reaction.Reaction"],"url":"http://humanmetabolism.org/"},{"name":"Entrez Gene","description":"","className":"lcsb.mapviewer.annotation.services.annotators.EntrezAnnotator","parametersDefinitions":[],"elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Rna","lcsb.mapviewer.model.map.species.Gene"],"url":"http://www.ncbi.nlm.nih.gov/gene"},{"name":"Ensembl","description":"","className":"lcsb.mapviewer.annotation.services.annotators.EnsemblAnnotator","parametersDefinitions":[],"elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Rna","lcsb.mapviewer.model.map.species.Gene"],"url":"www.ensembl.org"},{"name":"STITCH","description":"","className":"lcsb.mapviewer.annotation.services.annotators.StitchAnnotator","parametersDefinitions":[],"elementClassNames":["lcsb.mapviewer.model.map.species.SimpleMolecule"],"url":"http://stitch.embl.de/"},{"name":"STRING","description":"","className":"lcsb.mapviewer.annotation.services.annotators.StringAnnotator","parametersDefinitions":[],"elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"url":"http://string-db.org/"},{"name":"TAIR","description":"","className":"lcsb.mapviewer.annotation.services.annotators.TairAnnotator","parametersDefinitions":[],"elementClassNames":["lcsb.mapviewer.model.map.species.Protein","lcsb.mapviewer.model.map.species.Gene","lcsb.mapviewer.model.map.species.Rna"],"url":"http://arabidopsis.org/index.jsp"}],"buildDate":"            19/02/2018 11:28","reactionTypes":[{"name":"Catalysis","className":"lcsb.mapviewer.model.map.reaction.type.CatalysisReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Unknown positive influence","className":"lcsb.mapviewer.model.map.reaction.type.UnknownPositiveInfluenceReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Generic Reaction","className":"lcsb.mapviewer.model.map.reaction.Reaction","parentClass":"lcsb.mapviewer.model.map.BioEntity"},{"name":"Known transition omitted","className":"lcsb.mapviewer.model.map.reaction.type.KnownTransitionOmittedReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Reduced modulation","className":"lcsb.mapviewer.model.map.reaction.type.ReducedModulationReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Translation","className":"lcsb.mapviewer.model.map.reaction.type.TranslationReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Heterodimer association","className":"lcsb.mapviewer.model.map.reaction.type.HeterodimerAssociationReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Transcription","className":"lcsb.mapviewer.model.map.reaction.type.TranscriptionReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Unknown reduced trigger","className":"lcsb.mapviewer.model.map.reaction.type.UnknownReducedTriggerReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Unknown negative influence","className":"lcsb.mapviewer.model.map.reaction.type.UnknownNegativeInfluenceReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Truncation","className":"lcsb.mapviewer.model.map.reaction.type.TruncationReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Transport","className":"lcsb.mapviewer.model.map.reaction.type.TransportReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Unknown catalysis","className":"lcsb.mapviewer.model.map.reaction.type.UnknownCatalysisReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Reduced trigger","className":"lcsb.mapviewer.model.map.reaction.type.ReducedTriggerReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"State transition","className":"lcsb.mapviewer.model.map.reaction.type.StateTransitionReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Physical stimulation","className":"lcsb.mapviewer.model.map.reaction.type.PhysicalStimulationReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Boolean logic gate","className":"lcsb.mapviewer.model.map.reaction.type.BooleanLogicGateReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Dissociation","className":"lcsb.mapviewer.model.map.reaction.type.DissociationReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Inhibition","className":"lcsb.mapviewer.model.map.reaction.type.InhibitionReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Reduced physical stimulation","className":"lcsb.mapviewer.model.map.reaction.type.ReducedPhysicalStimulationReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Negative influence","className":"lcsb.mapviewer.model.map.reaction.type.NegativeInfluenceReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Unknown inhibition","className":"lcsb.mapviewer.model.map.reaction.type.UnknownInhibitionReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Modulation","className":"lcsb.mapviewer.model.map.reaction.type.ModulationReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Positive influence","className":"lcsb.mapviewer.model.map.reaction.type.PositiveInfluenceReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Unknown reduced physical stimulation","className":"lcsb.mapviewer.model.map.reaction.type.UnknownReducedPhysicalStimulationReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Unknown reduced modulation","className":"lcsb.mapviewer.model.map.reaction.type.UnknownReducedModulationReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Unknown transition","className":"lcsb.mapviewer.model.map.reaction.type.UnknownTransitionReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"},{"name":"Trigger","className":"lcsb.mapviewer.model.map.reaction.type.TriggerReaction","parentClass":"lcsb.mapviewer.model.map.reaction.Reaction"}],"version":"12.0.0","mapTypes":[{"name":"Downstream targets","id":"DOWNSTREAM_TARGETS"},{"name":"Pathway","id":"PATHWAY"},{"name":"Unknown","id":"UNKNOWN"}],"miriamTypes":{"CAZY":{"commonName":"CAZy","uris":["urn:miriam:cazy"],"homepage":"http://commonchemistry.org","registryIdentifier":"MIR:00000195"},"CHEMBL_TARGET":{"commonName":"ChEMBL target","uris":["urn:miriam:chembl.target"],"homepage":"https://www.ebi.ac.uk/chembldb/","registryIdentifier":"MIR:00000085"},"UNIPROT":{"commonName":"Uniprot","uris":["urn:miriam:uniprot"],"homepage":"http://www.uniprot.org/","registryIdentifier":"MIR:00000005"},"MI_R_BASE_MATURE_SEQUENCE":{"commonName":"miRBase Mature Sequence Database","uris":["urn:miriam:mirbase.mature"],"homepage":"http://www.mirbase.org/","registryIdentifier":"MIR:00000235"},"PFAM":{"commonName":"Protein Family Database","uris":["urn:miriam:pfam"],"homepage":"http://pfam.xfam.org//","registryIdentifier":"MIR:00000028"},"ENSEMBL_PLANTS":{"commonName":"Ensembl Plants","uris":["urn:miriam:ensembl.plant"],"homepage":"http://plants.ensembl.org/","registryIdentifier":"MIR:00000205"},"WIKIPEDIA":{"commonName":"Wikipedia (English)","uris":["urn:miriam:wikipedia.en"],"homepage":"http://en.wikipedia.org/wiki/Main_Page","registryIdentifier":"MIR:00000384"},"CHEBI":{"commonName":"Chebi","uris":["urn:miriam:obo.chebi","urn:miriam:chebi"],"homepage":"http://www.ebi.ac.uk/chebi/","registryIdentifier":"MIR:00000002"},"WIKIDATA":{"commonName":"Wikidata","uris":["urn:miriam:wikidata"],"homepage":"https://www.wikidata.org/","registryIdentifier":"MIR:00000549"},"REACTOME":{"commonName":"Reactome","uris":["urn:miriam:reactome"],"homepage":"http://www.reactome.org/","registryIdentifier":"MIR:00000018"},"EC":{"commonName":"Enzyme Nomenclature","uris":["urn:miriam:ec-code"],"homepage":"http://www.enzyme-database.org/","registryIdentifier":"MIR:00000004"},"DOI":{"commonName":"Digital Object Identifier","uris":["urn:miriam:doi"],"homepage":"http://www.doi.org/","registryIdentifier":"MIR:00000019"},"UNIPROT_ISOFORM":{"commonName":"UniProt Isoform","uris":["urn:miriam:uniprot.isoform"],"homepage":"http://www.uniprot.org/","registryIdentifier":"MIR:00000388"},"OMIM":{"commonName":"Online Mendelian Inheritance in Man","uris":["urn:miriam:omim"],"homepage":"http://omim.org/","registryIdentifier":"MIR:00000016"},"DRUGBANK_TARGET_V4":{"commonName":"DrugBank Target v4","uris":["urn:miriam:drugbankv4.target"],"homepage":"http://www.drugbank.ca/targets","registryIdentifier":"MIR:00000528"},"MIR_TAR_BASE_MATURE_SEQUENCE":{"commonName":"miRTarBase Mature Sequence Database","uris":["urn:miriam:mirtarbase"],"homepage":"http://mirtarbase.mbc.nctu.edu.tw/","registryIdentifier":"MIR:00100739"},"CHEMBL_COMPOUND":{"commonName":"ChEMBL","uris":["urn:miriam:chembl.compound"],"homepage":"https://www.ebi.ac.uk/chembldb/","registryIdentifier":"MIR:00000084"},"KEGG_PATHWAY":{"commonName":"Kegg Pathway","uris":["urn:miriam:kegg.pathway"],"homepage":"http://www.genome.jp/kegg/pathway.html","registryIdentifier":"MIR:00000012"},"CAS":{"commonName":"Chemical Abstracts Service","uris":["urn:miriam:cas"],"homepage":"http://commonchemistry.org","registryIdentifier":"MIR:00000237"},"REFSEQ":{"commonName":"RefSeq","uris":["urn:miriam:refseq"],"homepage":"http://www.ncbi.nlm.nih.gov/projects/RefSeq/","registryIdentifier":"MIR:00000039"},"WORM_BASE":{"commonName":"WormBase","uris":["urn:miriam:wormbase"],"homepage":"http://wormbase.bio2rdf.org/fct","registryIdentifier":"MIR:00000027"},"MI_R_BASE_SEQUENCE":{"commonName":"miRBase Sequence Database","uris":["urn:miriam:mirbase"],"homepage":"http://www.mirbase.org/","registryIdentifier":"MIR:00000078"},"TAIR_LOCUS":{"commonName":"TAIR Locus","uris":["urn:miriam:tair.locus"],"homepage":"http://arabidopsis.org/index.jsp","registryIdentifier":"MIR:00000050"},"PHARM":{"commonName":"PharmGKB Pathways","uris":["urn:miriam:pharmgkb.pathways"],"homepage":"http://www.pharmgkb.org/","registryIdentifier":"MIR:00000089"},"PDB":{"commonName":"Protein Data Bank","uris":["urn:miriam:pdb"],"homepage":"http://www.pdbe.org/","registryIdentifier":"MIR:00000020"},"PANTHER":{"commonName":"PANTHER Family","uris":["urn:miriam:panther.family","urn:miriam:panther"],"homepage":"http://www.pantherdb.org/","registryIdentifier":"MIR:00000060"},"TAXONOMY":{"commonName":"Taxonomy","uris":["urn:miriam:taxonomy"],"homepage":"http://www.ncbi.nlm.nih.gov/taxonomy/","registryIdentifier":"MIR:00000006"},"UNIGENE":{"commonName":"UniGene","uris":["urn:miriam:unigene"],"homepage":"http://www.ncbi.nlm.nih.gov/unigene","registryIdentifier":"MIR:00000346"},"HGNC":{"commonName":"HGNC","uris":["urn:miriam:hgnc"],"homepage":"http://www.genenames.org","registryIdentifier":"MIR:00000080"},"STITCH":{"commonName":"STITCH","uris":["urn:miriam:stitch"],"homepage":"http://stitch.embl.de/","registryIdentifier":"MIR:00100343"},"HGNC_SYMBOL":{"commonName":"HGNC Symbol","uris":["urn:miriam:hgnc.symbol"],"homepage":"http://www.genenames.org","registryIdentifier":"MIR:00000362"},"COG":{"commonName":"Clusters of Orthologous Groups","uris":["urn:miriam:cogs"],"homepage":"https://www.ncbi.nlm.nih.gov/COG/","registryIdentifier":"MIR:00000296"},"WIKIPATHWAYS":{"commonName":"WikiPathways","uris":["urn:miriam:wikipathways"],"homepage":"http://www.wikipathways.org/","registryIdentifier":"MIR:00000076"},"HMDB":{"commonName":"HMDB","uris":["urn:miriam:hmdb"],"homepage":"http://www.hmdb.ca/","registryIdentifier":"MIR:00000051"},"CHEMSPIDER":{"commonName":"ChemSpider","uris":["urn:miriam:chemspider"],"homepage":"http://www.chemspider.com//","registryIdentifier":"MIR:00000138"},"ENSEMBL":{"commonName":"Ensembl","uris":["urn:miriam:ensembl"],"homepage":"www.ensembl.org","registryIdentifier":"MIR:00000003"},"GO":{"commonName":"Gene Ontology","uris":["urn:miriam:obo.go","urn:miriam:go"],"homepage":"http://amigo.geneontology.org/amigo","registryIdentifier":"MIR:00000022"},"KEGG_REACTION":{"commonName":"Kegg Reaction","uris":["urn:miriam:kegg.reaction"],"homepage":"http://www.genome.jp/kegg/reaction/","registryIdentifier":"MIR:00000014"},"KEGG_ORTHOLOGY":{"commonName":"KEGG Orthology","uris":["urn:miriam:kegg.orthology"],"homepage":"http://www.genome.jp/kegg/ko.html","registryIdentifier":"MIR:00000116"},"PUBCHEM":{"commonName":"PubChem-compound","uris":["urn:miriam:pubchem.compound"],"homepage":"http://pubchem.ncbi.nlm.nih.gov/","registryIdentifier":"MIR:00000034"},"MESH_2012":{"commonName":"MeSH 2012","uris":["urn:miriam:mesh.2012","urn:miriam:mesh"],"homepage":"http://www.nlm.nih.gov/mesh/","registryIdentifier":"MIR:00000270"},"MGD":{"commonName":"Mouse Genome Database","uris":["urn:miriam:mgd"],"homepage":"http://www.informatics.jax.org/","registryIdentifier":"MIR:00000037"},"ENTREZ":{"commonName":"Entrez Gene","uris":["urn:miriam:ncbigene","urn:miriam:entrez.gene"],"homepage":"http://www.ncbi.nlm.nih.gov/gene","registryIdentifier":"MIR:00000069"},"PUBCHEM_SUBSTANCE":{"commonName":"PubChem-substance","uris":["urn:miriam:pubchem.substance"],"homepage":"http://pubchem.ncbi.nlm.nih.gov/","registryIdentifier":"MIR:00000033"},"CCDS":{"commonName":"Consensus CDS","uris":["urn:miriam:ccds"],"homepage":"http://www.ncbi.nlm.nih.gov/CCDS/","registryIdentifier":"MIR:00000375"},"KEGG_GENES":{"commonName":"Kegg Genes","uris":["urn:miriam:kegg.genes","urn:miriam:kegg.genes:hsa"],"homepage":"http://www.genome.jp/kegg/genes.html","registryIdentifier":"MIR:00000070"},"TOXICOGENOMIC_CHEMICAL":{"commonName":"Toxicogenomic Chemical","uris":["urn:miriam:ctd.chemical"],"homepage":"http://ctdbase.org/","registryIdentifier":"MIR:00000098"},"SGD":{"commonName":"Saccharomyces Genome Database","uris":["urn:miriam:sgd"],"homepage":"http://www.yeastgenome.org/","registryIdentifier":"MIR:00000023"},"KEGG_COMPOUND":{"commonName":"Kegg Compound","uris":["urn:miriam:kegg.compound"],"homepage":"http://www.genome.jp/kegg/ligand.html","registryIdentifier":"MIR:00000013"},"INTERPRO":{"commonName":"InterPro","uris":["urn:miriam:interpro"],"homepage":"http://www.ebi.ac.uk/interpro/","registryIdentifier":"MIR:00000011"},"BRENDA":{"commonName":"BRENDA","uris":["urn:miriam:brenda"],"homepage":"http://www.brenda-enzymes.org","registryIdentifier":"MIR:00100101"},"STRING":{"commonName":"STRING","uris":["urn:miriam:string"],"homepage":"http://string-db.org/","registryIdentifier":"MIR:00000265"},"UNKNOWN":{"commonName":"Unknown","uris":[],"homepage":null,"registryIdentifier":null},"DRUGBANK":{"commonName":"DrugBank","uris":["urn:miriam:drugbank"],"homepage":"http://www.drugbank.ca/","registryIdentifier":"MIR:00000102"},"PUBMED":{"commonName":"PubMed","uris":["urn:miriam:pubmed"],"homepage":"http://www.ncbi.nlm.nih.gov/PubMed/","registryIdentifier":"MIR:00000015"}},"unitTypes":[{"name":"ampere","id":"AMPERE"},{"name":"becquerel","id":"BECQUEREL"},{"name":"candela","id":"CANDELA"},{"name":"coulumb","id":"COULUMB"},{"name":"dimensionless","id":"DIMENSIONLESS"},{"name":"farad","id":"FARAD"},{"name":"gram","id":"GRAM"},{"name":"gray","id":"GRAY"},{"name":"henry","id":"HENRY"},{"name":"hertz","id":"HERTZ"},{"name":"item","id":"ITEM"},{"name":"joule","id":"JOULE"},{"name":"katal","id":"KATAL"},{"name":"kelvin","id":"KELVIN"},{"name":"kilogram","id":"KILOGRAM"},{"name":"litre","id":"LITRE"},{"name":"lumen","id":"LUMEN"},{"name":"lux","id":"LUX"},{"name":"metre","id":"METRE"},{"name":"mole","id":"MOLE"},{"name":"newton","id":"NEWTON"},{"name":"ohm","id":"OHM"},{"name":"pascal","id":"PASCAL"},{"name":"radian","id":"RADIAN"},{"name":"second","id":"SECOND"},{"name":"siemens","id":"SIEMENS"},{"name":"sievert","id":"SIEVERT"},{"name":"steradian","id":"STERADIAN"},{"name":"tesla","id":"TESLA"},{"name":"volt","id":"VOLT"},{"name":"watt","id":"WATT"},{"name":"weber","id":"WEBER"}],"options":[{"idObject":9,"type":"EMAIL_ADDRESS","value":"gawron13@o2.pl","valueType":"EMAIL","commonName":"E-mail address"},{"idObject":10,"type":"EMAIL_LOGIN","value":"gawron13","valueType":"STRING","commonName":"E-mail server login"},{"idObject":11,"type":"EMAIL_PASSWORD","value":"k13liszk!","valueType":"PASSWORD","commonName":"E-mail server password"},{"idObject":13,"type":"EMAIL_IMAP_SERVER","value":"your.imap.domain.com","valueType":"STRING","commonName":"IMAP server"},{"idObject":12,"type":"EMAIL_SMTP_SERVER","value":"poczta.o2.pl","valueType":"STRING","commonName":"SMTP server"},{"idObject":14,"type":"EMAIL_SMTP_PORT","value":"25","valueType":"INTEGER","commonName":"SMTP port"},{"idObject":6,"type":"DEFAULT_MAP","value":"sample","valueType":"STRING","commonName":"Default Project Id"},{"idObject":4,"type":"LOGO_IMG","value":"udl.png","valueType":"URL","commonName":"Logo icon"},{"idObject":3,"type":"LOGO_LINK","value":"http://wwwen.uni.lu/","valueType":"URL","commonName":"Logo link (after click)"},{"idObject":7,"type":"SEARCH_DISTANCE","value":"10","valueType":"DOUBLE","commonName":"Max distance for clicking on element (px)"},{"idObject":1,"type":"REQUEST_ACCOUNT_EMAIL","value":"your.email@domain.com","valueType":"EMAIL","commonName":"Email used for requesting an account"},{"idObject":8,"type":"SEARCH_RESULT_NUMBER","value":"100","valueType":"INTEGER","commonName":"Max number of results in search box. "},{"idObject":2,"type":"GOOGLE_ANALYTICS_IDENTIFIER","value":"","valueType":"STRING","commonName":"Google Analytics tracking ID used for statistics"},{"idObject":5,"type":"LOGO_TEXT","value":"University of Luxembourg","valueType":"STRING","commonName":"Logo description"},{"idObject":56,"type":"X_FRAME_DOMAIN","value":"http://localhost:8080/","valueType":"URL","commonName":"Domain allowed to connect via x-frame technology"},{"idObject":131,"type":"BIG_FILE_STORAGE_DIR","value":"minerva-big/","valueType":"STRING","commonName":"Path to store big files"},{"idObject":138,"type":"LEGEND_FILE_1","value":"resources/images/legend_a.png","valueType":"URL","commonName":"Legend 1 image file"},{"idObject":139,"type":"LEGEND_FILE_2","value":"resources/images/legend_b.png","valueType":"URL","commonName":"Legend 2 image file"},{"idObject":140,"type":"LEGEND_FILE_3","value":"resources/images/legend_c.png","valueType":"URL","commonName":"Legend 3 image file"},{"idObject":141,"type":"LEGEND_FILE_4","value":"resources/images/legend_d.png","valueType":"URL","commonName":"Legend 4 image file"},{"idObject":142,"type":"USER_MANUAL_FILE","value":"resources/other/user_guide.pdf","valueType":"URL","commonName":"User manual file"},{"idObject":205,"type":"MIN_COLOR_VAL","value":"FF0000","valueType":"COLOR","commonName":"Overlay color for negative values"},{"idObject":206,"type":"MAX_COLOR_VAL","value":"fbff00","valueType":"COLOR","commonName":"Overlay color for postive values"},{"idObject":218,"type":"SIMPLE_COLOR_VAL","value":"00ff40","valueType":"COLOR","commonName":"Overlay color when no values are defined"},{"idObject":239,"type":"NEUTRAL_COLOR_VAL","value":"0400ff","valueType":"COLOR","commonName":"Overlay color for value=0"},{"idObject":252,"type":"OVERLAY_OPACITY","value":"0.8","valueType":"DOUBLE","commonName":"Opacity used when drwaing data overlays (value between 0.0-1.0)"},{"idObject":253,"type":"REQUEST_ACCOUNT_DEFAULT_CONTENT","value":"Dear Diseas map team,\n\nI would like to request for an account.\n\nKind regards","valueType":"TEXT","commonName":"Email content used for requesting an account"},{"idObject":266,"type":"DEFAULT_VIEW_PROJECT","value":"true","valueType":"BOOLEAN","commonName":"Default user privilege for: View project"},{"idObject":267,"type":"DEFAULT_EDIT_COMMENTS_PROJECT","value":"true","valueType":"BOOLEAN","commonName":"Default user privilege for: Manage comments"},{"idObject":268,"type":"DEFAULT_LAYOUT_MANAGEMENT","value":"false","valueType":"BOOLEAN","commonName":"Default user privilege for: Manage layouts"}],"privilegeTypes":{"VIEW_PROJECT":{"commonName":"View project","valueType":"boolean","objectType":"Project"},"LAYOUT_MANAGEMENT":{"commonName":"Manage layouts","valueType":"boolean","objectType":"Project"},"PROJECT_MANAGEMENT":{"commonName":"Map management","valueType":"boolean","objectType":null},"CUSTOM_LAYOUTS":{"commonName":"Custom layouts","valueType":"int","objectType":null},"ADD_MAP":{"commonName":"Add project","valueType":"boolean","objectType":null},"LAYOUT_VIEW":{"commonName":"View layout","valueType":"boolean","objectType":"Layout"},"MANAGE_GENOMES":{"commonName":"Manage genomes","valueType":"boolean","objectType":null},"EDIT_COMMENTS_PROJECT":{"commonName":"Manage comments","valueType":"boolean","objectType":"Project"},"CONFIGURATION_MANAGE":{"commonName":"Manage configuration","valueType":"boolean","objectType":null},"USER_MANAGEMENT":{"commonName":"User management","valueType":"boolean","objectType":null}},"overlayTypes":[{"name":"GENERIC"},{"name":"GENETIC_VARIANT"}]}
\ No newline at end of file
diff --git a/frontend-js/testFiles/apiCalls/projects/sample/chemicals.search/query=rotenone&token=MOCK_TOKEN_ID& b/frontend-js/testFiles/apiCalls/projects/sample/chemicals.search/query=rotenone&token=MOCK_TOKEN_ID&
index 6725ccd2d28f63896912a21df5d2e8d361520c00..eeca958d68944ff03d08ef9d79d5799c1ef57b40 100644
--- a/frontend-js/testFiles/apiCalls/projects/sample/chemicals.search/query=rotenone&token=MOCK_TOKEN_ID&
+++ b/frontend-js/testFiles/apiCalls/projects/sample/chemicals.search/query=rotenone&token=MOCK_TOKEN_ID&
@@ -1 +1 @@
-[{"references":[{"resource":"D012402","link":"http://ctdbase.org/detail.go?type=chem&acc=D012402","id":0,"type":"TOXICOGENOMIC_CHEMICAL"},{"resource":"83-79-4","link":"http://commonchemistry.org/ChemicalDetail.aspx?ref=83-79-4","id":0,"type":"CAS"}],"synonyms":[],"name":"Rotenone","description":"A botanical insecticide that is an inhibitor of mitochondrial electron transport.","id":"Rotenone","directEvidenceReferences":[],"directEvidence":"marker/mechanism","targets":[{"targetElements":[],"references":[{"resource":"15796199","link":"http://www.ncbi.nlm.nih.gov/pubmed/15796199","type":"PUBMED","article":{"title":"In vitro search for synergy between flavonoids and epirubicin on multidrug-resistant cancer cells.","authors":["GyÊmÃ¥nt N"," Tanaka M"," Antus S"," Hohmann J"," Csuka O"," MÃ¥ndoky L"," MolnÃ¥r J."],"journal":"In vivo (Athens, Greece)","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15796199","id":"15796199","citationCount":15,"stringAuthors":"GyÊmÃ¥nt N,  Tanaka M,  Antus S,  Hohmann J,  Csuka O,  MÃ¥ndoky L,  MolnÃ¥r J."}}],"name":"ABCB1","targetParticipants":[{"resource":"ABCB1","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ABCB1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"23098804","link":"http://www.ncbi.nlm.nih.gov/pubmed/23098804","type":"PUBMED","article":{"title":"Rotenone-induced neurotoxicity in rat brain areas: a study on neuronal and neuronal supportive cells.","authors":["Swarnkar S"," Goswami P"," Kamat PK"," Patro IK"," Singh S"," Nath C."],"journal":"Neuroscience","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23098804","id":"23098804","citationCount":5,"stringAuthors":"Swarnkar S,  Goswami P,  Kamat PK,  Patro IK,  Singh S,  Nath C."}}],"name":"AIF1","targetParticipants":[{"resource":"AIF1","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AIF1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"22847264","link":"http://www.ncbi.nlm.nih.gov/pubmed/22847264","type":"PUBMED","article":{"title":"Characterization of cellular protective effects of ATP13A2/PARK9 expression and alterations resulting from pathogenic mutants.","authors":["Covy JP"," Waxman EA"," Giasson BI."],"journal":"Journal of neuroscience research","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22847264","id":"22847264","citationCount":15,"stringAuthors":"Covy JP,  Waxman EA,  Giasson BI."}}],"name":"ATP13A2","targetParticipants":[{"resource":"ATP13A2","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ATP13A2","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"17209049","link":"http://www.ncbi.nlm.nih.gov/pubmed/17209049","type":"PUBMED","article":{"title":"AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro.","authors":["Bogush A"," Pedrini S"," Pelta-Heller J"," Chan T"," Yang Q"," Mao Z"," Sluzas E"," Gieringer T"," Ehrlich ME."],"journal":"The Journal of biological chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17209049","id":"17209049","citationCount":30,"stringAuthors":"Bogush A,  Pedrini S,  Pelta-Heller J,  Chan T,  Yang Q,  Mao Z,  Sluzas E,  Gieringer T,  Ehrlich ME."}},{"resource":"18646205","link":"http://www.ncbi.nlm.nih.gov/pubmed/18646205","type":"PUBMED","article":{"title":"Pitx3-transfected astrocytes secrete brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor and protect dopamine neurons in mesencephalon cultures.","authors":["Yang D"," Peng C"," Li X"," Fan X"," Li L"," Ming M"," Chen S"," Le W."],"journal":"Journal of neuroscience research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18646205","id":"18646205","citationCount":13,"stringAuthors":"Yang D,  Peng C,  Li X,  Fan X,  Li L,  Ming M,  Chen S,  Le W."}},{"resource":"17442543","link":"http://www.ncbi.nlm.nih.gov/pubmed/17442543","type":"PUBMED","article":{"title":"Differential effects of classical and atypical antipsychotic drugs on rotenone-induced neurotoxicity in PC12 cells.","authors":["Tan QR"," Wang XZ"," Wang CY"," Liu XJ"," Chen YC"," Wang HH"," Zhang RG"," Zhen XC"," Tong Y"," Zhang ZJ."],"journal":"European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17442543","id":"17442543","citationCount":12,"stringAuthors":"Tan QR,  Wang XZ,  Wang CY,  Liu XJ,  Chen YC,  Wang HH,  Zhang RG,  Zhen XC,  Tong Y,  Zhang ZJ."}}],"name":"BDNF","targetParticipants":[{"resource":"BDNF","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=BDNF","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"19019832","link":"http://www.ncbi.nlm.nih.gov/pubmed/19019832","type":"PUBMED","article":{"title":"Reactive oxygen species regulate ceruloplasmin by a novel mRNA decay mechanism involving its 3'-untranslated region: implications in neurodegenerative diseases.","authors":["Tapryal N"," Mukhopadhyay C"," Das D"," Fox PL"," Mukhopadhyay CK."],"journal":"The Journal of Biological Chemistry","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19019832","id":"19019832","citationCount":18,"stringAuthors":"Tapryal N,  Mukhopadhyay C,  Das D,  Fox PL,  Mukhopadhyay CK."}},{"resource":"18804145","link":"http://www.ncbi.nlm.nih.gov/pubmed/18804145","type":"PUBMED","article":{"title":"Increased vulnerability to rotenone-induced neurotoxicity in ceruloplasmin-deficient mice.","authors":["Kaneko K"," Hineno A"," Yoshida K"," Ikeda S."],"journal":"Neuroscience letters","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18804145","id":"18804145","citationCount":11,"stringAuthors":"Kaneko K,  Hineno A,  Yoshida K,  Ikeda S."}}],"name":"CP","targetParticipants":[{"resource":"CP","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=CP","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"24764117","link":"http://www.ncbi.nlm.nih.gov/pubmed/24764117","type":"PUBMED","article":{"title":"RTP801 regulates maneb- and mancozeb-induced cytotoxicity via NF-κB.","authors":["Cheng SY"," Oh S"," Velasco M"," Ta C"," Montalvo J"," Calderone A."],"journal":"Journal of biochemical and molecular toxicology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24764117","id":"24764117","citationCount":1,"stringAuthors":"Cheng SY,  Oh S,  Velasco M,  Ta C,  Montalvo J,  Calderone A."}}],"name":"DDIT4","targetParticipants":[{"resource":"DDIT4","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DDIT4","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"20887679","link":"http://www.ncbi.nlm.nih.gov/pubmed/20887679","type":"PUBMED","article":{"title":"Dopamine D� and Dâ‚‚ receptor subtypes functional regulation in corpus striatum of unilateral rotenone lesioned Parkinson's rat model: effect of serotonin, dopamine and norepinephrine.","authors":["Paul J"," Nandhu MS"," Kuruvilla KP"," Paulose CS."],"journal":"Neurological research","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20887679","id":"20887679","citationCount":2,"stringAuthors":"Paul J,  Nandhu MS,  Kuruvilla KP,  Paulose CS."}}],"name":"DRD1","targetParticipants":[{"resource":"DRD1","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DRD1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"18289173","link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","type":"PUBMED","article":{"title":"Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats.","authors":["Lin CH"," Huang JY"," Ching CH"," Chuang JI."],"journal":"Journal of pineal research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","id":"18289173","citationCount":32,"stringAuthors":"Lin CH,  Huang JY,  Ching CH,  Chuang JI."}},{"resource":"20887679","link":"http://www.ncbi.nlm.nih.gov/pubmed/20887679","type":"PUBMED","article":{"title":"Dopamine D� and Dâ‚‚ receptor subtypes functional regulation in corpus striatum of unilateral rotenone lesioned Parkinson's rat model: effect of serotonin, dopamine and norepinephrine.","authors":["Paul J"," Nandhu MS"," Kuruvilla KP"," Paulose CS."],"journal":"Neurological research","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20887679","id":"20887679","citationCount":2,"stringAuthors":"Paul J,  Nandhu MS,  Kuruvilla KP,  Paulose CS."}}],"name":"DRD2","targetParticipants":[{"resource":"DRD2","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DRD2","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"11078378","link":"http://www.ncbi.nlm.nih.gov/pubmed/11078378","type":"PUBMED","article":{"title":"Mitochondrial dysfunction increases expression of endothelin-1 and induces apoptosis through caspase-3 activation in rat cardiomyocytes in vitro.","authors":["Yuki K"," Miyauchi T"," Kakinuma Y"," Murakoshi N"," Suzuki T"," Hayashi J"," Goto K"," Yamaguchi I."],"journal":"Journal of cardiovascular pharmacology","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11078378","id":"11078378","citationCount":9,"stringAuthors":"Yuki K,  Miyauchi T,  Kakinuma Y,  Murakoshi N,  Suzuki T,  Hayashi J,  Goto K,  Yamaguchi I."}},{"resource":"11707688","link":"http://www.ncbi.nlm.nih.gov/pubmed/11707688","type":"PUBMED","article":{"title":"Endothelin-1 production is enhanced by rotenone, a mitochondrial complex I inhibitor, in cultured rat cardiomyocytes.","authors":["Yuhki KI"," Miyauchi T"," Kakinuma Y"," Murakoshi N"," Maeda S"," Goto K"," Yamaguchi I"," Suzuki T."],"journal":"Journal of cardiovascular pharmacology","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11707688","id":"11707688","citationCount":7,"stringAuthors":"Yuhki KI,  Miyauchi T,  Kakinuma Y,  Murakoshi N,  Maeda S,  Goto K,  Yamaguchi I,  Suzuki T."}},{"resource":"22928487","link":"http://www.ncbi.nlm.nih.gov/pubmed/22928487","type":"PUBMED","article":{"title":"Mitochondrial ROS-K+ channel signaling pathway regulated secretion of human pulmonary artery endothelial cells.","authors":["Ouyang JS"," Li YP"," Li CY"," Cai C"," Chen CS"," Chen SX"," Chen YF"," Yang L"," Xie YP."],"journal":"Free radical research","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22928487","id":"22928487","citationCount":5,"stringAuthors":"Ouyang JS,  Li YP,  Li CY,  Cai C,  Chen CS,  Chen SX,  Chen YF,  Yang L,  Xie YP."}}],"name":"EDN1","targetParticipants":[{"resource":"EDN1","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=EDN1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"18646205","link":"http://www.ncbi.nlm.nih.gov/pubmed/18646205","type":"PUBMED","article":{"title":"Pitx3-transfected astrocytes secrete brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor and protect dopamine neurons in mesencephalon cultures.","authors":["Yang D"," Peng C"," Li X"," Fan X"," Li L"," Ming M"," Chen S"," Le W."],"journal":"Journal of neuroscience research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18646205","id":"18646205","citationCount":13,"stringAuthors":"Yang D,  Peng C,  Li X,  Fan X,  Li L,  Ming M,  Chen S,  Le W."}}],"name":"GDNF","targetParticipants":[{"resource":"GDNF","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GDNF","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"23098804","link":"http://www.ncbi.nlm.nih.gov/pubmed/23098804","type":"PUBMED","article":{"title":"Rotenone-induced neurotoxicity in rat brain areas: a study on neuronal and neuronal supportive cells.","authors":["Swarnkar S"," Goswami P"," Kamat PK"," Patro IK"," Singh S"," Nath C."],"journal":"Neuroscience","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23098804","id":"23098804","citationCount":5,"stringAuthors":"Swarnkar S,  Goswami P,  Kamat PK,  Patro IK,  Singh S,  Nath C."}}],"name":"GFAP","targetParticipants":[{"resource":"GFAP","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GFAP","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"17079513","link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","type":"PUBMED","article":{"title":"Microtubule: a common target for parkin and Parkinson's disease toxins.","authors":["Feng J."],"journal":"The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","id":"17079513","citationCount":34,"stringAuthors":"Feng J."}},{"resource":"17070561","link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","type":"PUBMED","article":{"title":"Standardized Hypericum perforatum reduces oxidative stress and increases gene expression of antioxidant enzymes on rotenone-exposed rats.","authors":["SÃ¥nchez-Reus MI"," Gómez del Rio MA"," Iglesias I"," Elorza M"," Slowing K"," Benedí J."],"journal":"Neuropharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","id":"17070561","citationCount":21,"stringAuthors":"SÃ¥nchez-Reus MI,  Gómez del Rio MA,  Iglesias I,  Elorza M,  Slowing K,  Benedí J."}},{"resource":"15904944","link":"http://www.ncbi.nlm.nih.gov/pubmed/15904944","type":"PUBMED","article":{"title":"Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine.","authors":["Molina-JimÊnez MF"," SÃ¥nchez-Reus MI"," Cascales M"," AndrÊs D"," Benedí J."],"journal":"Toxicology and applied pharmacology","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15904944","id":"15904944","citationCount":14,"stringAuthors":"Molina-JimÊnez MF,  SÃ¥nchez-Reus MI,  Cascales M,  AndrÊs D,  Benedí J."}},{"resource":"17657281","link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","type":"PUBMED","article":{"title":"The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.","authors":["Panee J"," Liu W"," Nakamura K"," Berry MJ."],"journal":"International journal of biological sciences","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":"17657281","citationCount":13,"stringAuthors":"Panee J,  Liu W,  Nakamura K,  Berry MJ."}}],"name":"GPX1","targetParticipants":[{"resource":"GPX1","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GPX1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"23186747","link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","type":"PUBMED","article":{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":5,"stringAuthors":"Yap YW,  Chen MJ,  Peng ZF,  Manikandan J,  Ng JM,  Llanos RM,  La Fontaine S,  Beart PM,  Cheung NS."}}],"name":"GSTA4","targetParticipants":[{"resource":"GSTA4","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GSTA4","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"23186747","link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","type":"PUBMED","article":{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":5,"stringAuthors":"Yap YW,  Chen MJ,  Peng ZF,  Manikandan J,  Ng JM,  Llanos RM,  La Fontaine S,  Beart PM,  Cheung NS."}}],"name":"GSTM1","targetParticipants":[{"resource":"GSTM1","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GSTM1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"19131585","link":"http://www.ncbi.nlm.nih.gov/pubmed/19131585","type":"PUBMED","article":{"title":"Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells.","authors":["Han Z"," Varadharaj S"," Giedt RJ"," Zweier JL"," Szeto HH"," Alevriadou BR."],"journal":"The Journal of pharmacology and experimental therapeutics","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19131585","id":"19131585","citationCount":34,"stringAuthors":"Han Z,  Varadharaj S,  Giedt RJ,  Zweier JL,  Szeto HH,  Alevriadou BR."}},{"resource":"24451142","link":"http://www.ncbi.nlm.nih.gov/pubmed/24451142","type":"PUBMED","article":{"title":"Resveratrol partially prevents rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through induction of heme oxygenase-1 dependent autophagy.","authors":["Lin TK"," Chen SD"," Chuang YC"," Lin HY"," Huang CR"," Chuang JH"," Wang PW"," Huang ST"," Tiao MM"," Chen JB"," Liou CW."],"journal":"International journal of molecular sciences","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24451142","id":"24451142","citationCount":27,"stringAuthors":"Lin TK,  Chen SD,  Chuang YC,  Lin HY,  Huang CR,  Chuang JH,  Wang PW,  Huang ST,  Tiao MM,  Chen JB,  Liou CW."}},{"resource":"17702527","link":"http://www.ncbi.nlm.nih.gov/pubmed/17702527","type":"PUBMED","article":{"title":"Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screening.","authors":["Coe KJ"," Jia Y"," Ho HK"," Rademacher P"," Bammler TK"," Beyer RP"," Farin FM"," Woodke L"," Plymate SR"," Fausto N"," Nelson SD."],"journal":"Chemical research in toxicology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17702527","id":"17702527","citationCount":23,"stringAuthors":"Coe KJ,  Jia Y,  Ho HK,  Rademacher P,  Bammler TK,  Beyer RP,  Farin FM,  Woodke L,  Plymate SR,  Fausto N,  Nelson SD."}},{"resource":"22659318","link":"http://www.ncbi.nlm.nih.gov/pubmed/22659318","type":"PUBMED","article":{"title":"Cadmium-induced apoptosis in the BJAB human B cell line: involvement of PKC/ERK1/2/JNK signaling pathways in HO-1 expression.","authors":["Nemmiche S"," Chabane-Sari D"," Kadri M"," Guiraud P."],"journal":"Toxicology","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22659318","id":"22659318","citationCount":16,"stringAuthors":"Nemmiche S,  Chabane-Sari D,  Kadri M,  Guiraud P."}},{"resource":"17657281","link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","type":"PUBMED","article":{"title":"The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.","authors":["Panee J"," Liu W"," Nakamura K"," Berry MJ."],"journal":"International journal of biological sciences","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":"17657281","citationCount":13,"stringAuthors":"Panee J,  Liu W,  Nakamura K,  Berry MJ."}},{"resource":"23186747","link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","type":"PUBMED","article":{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":5,"stringAuthors":"Yap YW,  Chen MJ,  Peng ZF,  Manikandan J,  Ng JM,  Llanos RM,  La Fontaine S,  Beart PM,  Cheung NS."}},{"resource":"26276080","link":"http://www.ncbi.nlm.nih.gov/pubmed/26276080","type":"PUBMED","article":{"title":"Pyrroloquinoline quinone-conferred neuroprotection in rotenone models of Parkinson's disease.","authors":["Qin J"," Wu M"," Yu S"," Gao X"," Zhang J"," Dong X"," Ji J"," Zhang Y"," Zhou L"," Zhang Q"," Ding F."],"journal":"Toxicology letters","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26276080","id":"26276080","citationCount":3,"stringAuthors":"Qin J,  Wu M,  Yu S,  Gao X,  Zhang J,  Dong X,  Ji J,  Zhang Y,  Zhou L,  Zhang Q,  Ding F."}}],"name":"HMOX1","targetParticipants":[{"resource":"HMOX1","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HMOX1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"27979718","link":"http://www.ncbi.nlm.nih.gov/pubmed/27979718","type":"PUBMED","article":{"title":"Neonatal rotenone lesions cause onset of hyperactivity during juvenile and adulthood in the rat.","authors":["Ishido M"," Suzuki J"," Masuo Y."],"journal":"Toxicology letters","year":2017,"link":"http://www.ncbi.nlm.nih.gov/pubmed/27979718","id":"27979718","citationCount":0,"stringAuthors":"Ishido M,  Suzuki J,  Masuo Y."}}],"name":"HSPA1A","targetParticipants":[{"resource":"HSPA1A","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSPA1A","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"16565515","link":"http://www.ncbi.nlm.nih.gov/pubmed/16565515","type":"PUBMED","article":{"title":"Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease.","authors":["Jin J"," Hulette C"," Wang Y"," Zhang T"," Pan C"," Wadhwa R"," Zhang J."],"journal":"Molecular & cellular proteomics : MCP","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16565515","id":"16565515","citationCount":110,"stringAuthors":"Jin J,  Hulette C,  Wang Y,  Zhang T,  Pan C,  Wadhwa R,  Zhang J."}},{"resource":"23186747","link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","type":"PUBMED","article":{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":5,"stringAuthors":"Yap YW,  Chen MJ,  Peng ZF,  Manikandan J,  Ng JM,  Llanos RM,  La Fontaine S,  Beart PM,  Cheung NS."}}],"name":"HSPA9","targetParticipants":[{"resource":"HSPA9","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSPA9","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"27900601","link":"http://www.ncbi.nlm.nih.gov/pubmed/27900601","type":"PUBMED","article":{"title":"RNA-Seq Expression Analysis of Enteric Neuron Cells with Rotenone Treatment and Prediction of Regulated Pathways.","authors":["Guan Q"," Wang X"," Jiang Y"," Zhao L"," Nie Z"," Jin L."],"journal":"Neurochemical research","year":2017,"link":"http://www.ncbi.nlm.nih.gov/pubmed/27900601","id":"27900601","citationCount":0,"stringAuthors":"Guan Q,  Wang X,  Jiang Y,  Zhao L,  Nie Z,  Jin L."}}],"name":"IGF2","targetParticipants":[{"resource":"IGF2","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IGF2","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"11950692","link":"http://www.ncbi.nlm.nih.gov/pubmed/11950692","type":"PUBMED","article":{"title":"Role of mitochondrial oxidant generation in endothelial cell responses to hypoxia.","authors":["Pearlstein DP"," Ali MH"," Mungai PT"," Hynes KL"," Gewertz BL"," Schumacker PT."],"journal":"Arteriosclerosis, thrombosis, and vascular biology","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11950692","id":"11950692","citationCount":54,"stringAuthors":"Pearlstein DP,  Ali MH,  Mungai PT,  Hynes KL,  Gewertz BL,  Schumacker PT."}},{"resource":"15135310","link":"http://www.ncbi.nlm.nih.gov/pubmed/15135310","type":"PUBMED","article":{"title":"Inverse gene expression patterns for macrophage activating hepatotoxicants and peroxisome proliferators in rat liver.","authors":["McMillian M"," Nie AY"," Parker JB"," Leone A"," Kemmerer M"," Bryant S"," Herlich J"," Yieh L"," Bittner A"," Liu X"," Wan J"," Johnson MD."],"journal":"Biochemical pharmacology","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15135310","id":"15135310","citationCount":27,"stringAuthors":"McMillian M,  Nie AY,  Parker JB,  Leone A,  Kemmerer M,  Bryant S,  Herlich J,  Yieh L,  Bittner A,  Liu X,  Wan J,  Johnson MD."}},{"resource":"16837928","link":"http://www.ncbi.nlm.nih.gov/pubmed/16837928","type":"PUBMED","article":{"title":"Albumin-bound fatty acids induce mitochondrial oxidant stress and impair antioxidant responses in proximal tubular cells.","authors":["Ishola DA"," Post JA"," van Timmeren MM"," Bakker SJ"," Goldschmeding R"," Koomans HA"," Braam B"," Joles JA."],"journal":"Kidney international","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16837928","id":"16837928","citationCount":26,"stringAuthors":"Ishola DA,  Post JA,  van Timmeren MM,  Bakker SJ,  Goldschmeding R,  Koomans HA,  Braam B,  Joles JA."}},{"resource":"19635391","link":"http://www.ncbi.nlm.nih.gov/pubmed/19635391","type":"PUBMED","article":{"title":"Environmental toxicants inhibit neuronal Jak tyrosine kinase by mitochondrial disruption.","authors":["Monroe RK"," Halvorsen SW."],"journal":"Neurotoxicology","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19635391","id":"19635391","citationCount":16,"stringAuthors":"Monroe RK,  Halvorsen SW."}},{"resource":"22745725","link":"http://www.ncbi.nlm.nih.gov/pubmed/22745725","type":"PUBMED","article":{"title":"Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat.","authors":["Paulus P"," Ockelmann P"," Tacke S"," Karnowski N"," Ellinghaus P"," Scheller B"," Holfeld J"," Urbschat A"," Zacharowski K."],"journal":"PloS one","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22745725","id":"22745725","citationCount":10,"stringAuthors":"Paulus P,  Ockelmann P,  Tacke S,  Karnowski N,  Ellinghaus P,  Scheller B,  Holfeld J,  Urbschat A,  Zacharowski K."}},{"resource":"24830863","link":"http://www.ncbi.nlm.nih.gov/pubmed/24830863","type":"PUBMED","article":{"title":"Rotenone, a mitochondrial respiratory complex I inhibitor, ameliorates lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice.","authors":["Ai Q"," Jing Y"," Jiang R"," Lin L"," Dai J"," Che Q"," Zhou D"," Jia M"," Wan J"," Zhang L."],"journal":"International immunopharmacology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24830863","id":"24830863","citationCount":8,"stringAuthors":"Ai Q,  Jing Y,  Jiang R,  Lin L,  Dai J,  Che Q,  Zhou D,  Jia M,  Wan J,  Zhang L."}},{"resource":"23867654","link":"http://www.ncbi.nlm.nih.gov/pubmed/23867654","type":"PUBMED","article":{"title":"Reactive oxygen species regulate context-dependent inhibition of NFAT5 target genes.","authors":["Kim NH"," Hong BK"," Choi SY"," Moo Kwon H"," Cho CS"," Yi EC"," Kim WU."],"journal":"Experimental & molecular medicine","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23867654","id":"23867654","citationCount":5,"stringAuthors":"Kim NH,  Hong BK,  Choi SY,  Moo Kwon H,  Cho CS,  Yi EC,  Kim WU."}}],"name":"IL6","targetParticipants":[{"resource":"IL6","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IL6","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"18619942","link":"http://www.ncbi.nlm.nih.gov/pubmed/18619942","type":"PUBMED","article":{"title":"Overexpression of Kir2.3 in PC12 cells resists rotenone-induced neurotoxicity associated with PKC signaling pathway.","authors":["Wang G"," Zeng J"," Shen CY"," Wang ZQ"," Chen SD."],"journal":"Biochemical and biophysical research communications","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18619942","id":"18619942","citationCount":3,"stringAuthors":"Wang G,  Zeng J,  Shen CY,  Wang ZQ,  Chen SD."}}],"name":"KCNJ4","targetParticipants":[{"resource":"KCNJ4","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=KCNJ4","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"19625511","link":"http://www.ncbi.nlm.nih.gov/pubmed/19625511","type":"PUBMED","article":{"title":"LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans.","authors":["Saha S"," Guillily MD"," Ferree A"," Lanceta J"," Chan D"," Ghosh J"," Hsu CH"," Segal L"," Raghavan K"," Matsumoto K"," Hisamoto N"," Kuwahara T"," Iwatsubo T"," Moore L"," Goldstein L"," Cookson M"," Wolozin B."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19625511","id":"19625511","citationCount":97,"stringAuthors":"Saha S,  Guillily MD,  Ferree A,  Lanceta J,  Chan D,  Ghosh J,  Hsu CH,  Segal L,  Raghavan K,  Matsumoto K,  Hisamoto N,  Kuwahara T,  Iwatsubo T,  Moore L,  Goldstein L,  Cookson M,  Wolozin B."}},{"resource":"19741132","link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","type":"PUBMED","article":{"title":"Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.","authors":["Ng CH"," Mok SZ"," Koh C"," Ouyang X"," Fivaz ML"," Tan EK"," Dawson VL"," Dawson TM"," Yu F"," Lim KL."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","id":"19741132","citationCount":90,"stringAuthors":"Ng CH,  Mok SZ,  Koh C,  Ouyang X,  Fivaz ML,  Tan EK,  Dawson VL,  Dawson TM,  Yu F,  Lim KL."}},{"resource":"19692353","link":"http://www.ncbi.nlm.nih.gov/pubmed/19692353","type":"PUBMED","article":{"title":"Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease.","authors":["Venderova K"," Kabbach G"," Abdel-Messih E"," Zhang Y"," Parks RJ"," Imai Y"," Gehrke S"," Ngsee J"," Lavoie MJ"," Slack RS"," Rao Y"," Zhang Z"," Lu B"," Haque ME"," Park DS."],"journal":"Human molecular genetics","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19692353","id":"19692353","citationCount":78,"stringAuthors":"Venderova K,  Kabbach G,  Abdel-Messih E,  Zhang Y,  Parks RJ,  Imai Y,  Gehrke S,  Ngsee J,  Lavoie MJ,  Slack RS,  Rao Y,  Zhang Z,  Lu B,  Haque ME,  Park DS."}},{"resource":"18322385","link":"http://www.ncbi.nlm.nih.gov/pubmed/18322385","type":"PUBMED","article":{"title":"Investigating convergent actions of genes linked to familial Parkinson's disease.","authors":["Wolozin B"," Saha S"," Guillily M"," Ferree A"," Riley M."],"journal":"Neuro-degenerative diseases","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18322385","id":"18322385","citationCount":19,"stringAuthors":"Wolozin B,  Saha S,  Guillily M,  Ferree A,  Riley M."}}],"name":"LRRK2","targetParticipants":[{"resource":"LRRK2","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LRRK2","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"16449798","link":"http://www.ncbi.nlm.nih.gov/pubmed/16449798","type":"PUBMED","article":{"title":"Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice.","authors":["Hsieh CC"," Papaconstantinou J."],"journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16449798","id":"16449798","citationCount":84,"stringAuthors":"Hsieh CC,  Papaconstantinou J."}}],"name":"MAP3K5","targetParticipants":[{"resource":"MAP3K5","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MAP3K5","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"16219024","link":"http://www.ncbi.nlm.nih.gov/pubmed/16219024","type":"PUBMED","article":{"title":"The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy.","authors":["Höglinger GU"," Lannuzel A"," Khondiker ME"," Michel PP"," Duyckaerts C"," Féger J"," Champy P"," Prigent A"," Medja F"," Lombes A"," Oertel WH"," Ruberg M"," Hirsch EC."],"journal":"Journal of neurochemistry","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16219024","id":"16219024","citationCount":76,"stringAuthors":"Höglinger GU,  Lannuzel A,  Khondiker ME,  Michel PP,  Duyckaerts C,  Féger J,  Champy P,  Prigent A,  Medja F,  Lombes A,  Oertel WH,  Ruberg M,  Hirsch EC."}},{"resource":"16930453","link":"http://www.ncbi.nlm.nih.gov/pubmed/16930453","type":"PUBMED","article":{"title":"Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.","authors":["Dickey CA"," Ash P"," Klosak N"," Lee WC"," Petrucelli L"," Hutton M"," Eckman CB."],"journal":"Molecular neurodegeneration","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16930453","id":"16930453","citationCount":17,"stringAuthors":"Dickey CA,  Ash P,  Klosak N,  Lee WC,  Petrucelli L,  Hutton M,  Eckman CB."}}],"name":"MAPT","targetParticipants":[{"resource":"MAPT","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MAPT","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"24374061","link":"http://www.ncbi.nlm.nih.gov/pubmed/24374061","type":"PUBMED","article":{"title":"PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1.","authors":["Corona JC"," de Souza SC"," Duchen MR."],"journal":"Experimental neurology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24374061","id":"24374061","citationCount":12,"stringAuthors":"Corona JC,  de Souza SC,  Duchen MR."}},{"resource":"23186747","link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","type":"PUBMED","article":{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":5,"stringAuthors":"Yap YW,  Chen MJ,  Peng ZF,  Manikandan J,  Ng JM,  Llanos RM,  La Fontaine S,  Beart PM,  Cheung NS."}}],"name":"NQO1","targetParticipants":[{"resource":"NQO1","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NQO1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"20940149","link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","type":"PUBMED","article":{"title":"DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.","authors":["Thomas KJ"," McCoy MK"," Blackinton J"," Beilina A"," van der Brug M"," Sandebring A"," Miller D"," Maric D"," Cedazo-Minguez A"," Cookson MR."],"journal":"Human molecular genetics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","id":"20940149","citationCount":148,"stringAuthors":"Thomas KJ,  McCoy MK,  Blackinton J,  Beilina A,  van der Brug M,  Sandebring A,  Miller D,  Maric D,  Cedazo-Minguez A,  Cookson MR."}},{"resource":"19741132","link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","type":"PUBMED","article":{"title":"Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.","authors":["Ng CH"," Mok SZ"," Koh C"," Ouyang X"," Fivaz ML"," Tan EK"," Dawson VL"," Dawson TM"," Yu F"," Lim KL."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","id":"19741132","citationCount":90,"stringAuthors":"Ng CH,  Mok SZ,  Koh C,  Ouyang X,  Fivaz ML,  Tan EK,  Dawson VL,  Dawson TM,  Yu F,  Lim KL."}},{"resource":"16573651","link":"http://www.ncbi.nlm.nih.gov/pubmed/16573651","type":"PUBMED","article":{"title":"Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline.","authors":["Casarejos MJ"," Menéndez J"," Solano RM"," Rodríguez-Navarro JA"," García de Yébenes J"," Mena MA."],"journal":"Journal of neurochemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16573651","id":"16573651","citationCount":66,"stringAuthors":"Casarejos MJ,  Menéndez J,  Solano RM,  Rodríguez-Navarro JA,  García de Yébenes J,  Mena MA."}},{"resource":"22872702","link":"http://www.ncbi.nlm.nih.gov/pubmed/22872702","type":"PUBMED","article":{"title":"ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons.","authors":["Joselin AP"," Hewitt SJ"," Callaghan SM"," Kim RH"," Chung YH"," Mak TW"," Shen J"," Slack RS"," Park DS."],"journal":"Human molecular genetics","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22872702","id":"22872702","citationCount":59,"stringAuthors":"Joselin AP,  Hewitt SJ,  Callaghan SM,  Kim RH,  Chung YH,  Mak TW,  Shen J,  Slack RS,  Park DS."}},{"resource":"17687034","link":"http://www.ncbi.nlm.nih.gov/pubmed/17687034","type":"PUBMED","article":{"title":"Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities.","authors":["Wang C"," Lu R"," Ouyang X"," Ho MW"," Chia W"," Yu F"," Lim KL."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17687034","id":"17687034","citationCount":52,"stringAuthors":"Wang C,  Lu R,  Ouyang X,  Ho MW,  Chia W,  Yu F,  Lim KL."}},{"resource":"16517603","link":"http://www.ncbi.nlm.nih.gov/pubmed/16517603","type":"PUBMED","article":{"title":"Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells.","authors":["Rosen KM"," Veereshwarayya V"," Moussa CE"," Fu Q"," Goldberg MS"," Schlossmacher MG"," Shen J"," Querfurth HW."],"journal":"The Journal of Biological Chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16517603","id":"16517603","citationCount":45,"stringAuthors":"Rosen KM,  Veereshwarayya V,  Moussa CE,  Fu Q,  Goldberg MS,  Schlossmacher MG,  Shen J,  Querfurth HW."}}],"name":"PARK2","targetParticipants":[{"resource":"PARK2","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PARK2","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"20940149","link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","type":"PUBMED","article":{"title":"DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.","authors":["Thomas KJ"," McCoy MK"," Blackinton J"," Beilina A"," van der Brug M"," Sandebring A"," Miller D"," Maric D"," Cedazo-Minguez A"," Cookson MR."],"journal":"Human molecular genetics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","id":"20940149","citationCount":148,"stringAuthors":"Thomas KJ,  McCoy MK,  Blackinton J,  Beilina A,  van der Brug M,  Sandebring A,  Miller D,  Maric D,  Cedazo-Minguez A,  Cookson MR."}},{"resource":"16439141","link":"http://www.ncbi.nlm.nih.gov/pubmed/16439141","type":"PUBMED","article":{"title":"Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system.","authors":["Betarbet R"," Canet-Aviles RM"," Sherer TB"," Mastroberardino PG"," McLendon C"," Kim JH"," Lund S"," Na HM"," Taylor G"," Bence NF"," Kopito R"," Seo BB"," Yagi T"," Yagi A"," Klinefelter G"," Cookson MR"," Greenamyre JT."],"journal":"Neurobiology of disease","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16439141","id":"16439141","citationCount":131,"stringAuthors":"Betarbet R,  Canet-Aviles RM,  Sherer TB,  Mastroberardino PG,  McLendon C,  Kim JH,  Lund S,  Na HM,  Taylor G,  Bence NF,  Kopito R,  Seo BB,  Yagi T,  Yagi A,  Klinefelter G,  Cookson MR,  Greenamyre JT."}},{"resource":"17459145","link":"http://www.ncbi.nlm.nih.gov/pubmed/17459145","type":"PUBMED","article":{"title":"Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.","authors":["Inden M"," Kitamura Y"," Takeuchi H"," Yanagida T"," Takata K"," Kobayashi Y"," Taniguchi T"," Yoshimoto K"," Kaneko M"," Okuma Y"," Taira T"," Ariga H"," Shimohama S."],"journal":"Journal of neurochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17459145","id":"17459145","citationCount":68,"stringAuthors":"Inden M,  Kitamura Y,  Takeuchi H,  Yanagida T,  Takata K,  Kobayashi Y,  Taniguchi T,  Yoshimoto K,  Kaneko M,  Okuma Y,  Taira T,  Ariga H,  Shimohama S."}},{"resource":"18377993","link":"http://www.ncbi.nlm.nih.gov/pubmed/18377993","type":"PUBMED","article":{"title":"Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection.","authors":["Lev N"," Ickowicz D"," Melamed E"," Offen D."],"journal":"Neurotoxicology","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18377993","id":"18377993","citationCount":59,"stringAuthors":"Lev N,  Ickowicz D,  Melamed E,  Offen D."}},{"resource":"18331584","link":"http://www.ncbi.nlm.nih.gov/pubmed/18331584","type":"PUBMED","article":{"title":"Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease.","authors":["Liu F"," Nguyen JL"," Hulleman JD"," Li L"," Rochet JC."],"journal":"Journal of neurochemistry","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18331584","id":"18331584","citationCount":48,"stringAuthors":"Liu F,  Nguyen JL,  Hulleman JD,  Li L,  Rochet JC."}},{"resource":"18930142","link":"http://www.ncbi.nlm.nih.gov/pubmed/18930142","type":"PUBMED","article":{"title":"DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone.","authors":["Mullett SJ"," Hinkle DA."],"journal":"Neurobiology of disease","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18930142","id":"18930142","citationCount":43,"stringAuthors":"Mullett SJ,  Hinkle DA."}},{"resource":"16624565","link":"http://www.ncbi.nlm.nih.gov/pubmed/16624565","type":"PUBMED","article":{"title":"Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase.","authors":["Pisani A"," Martella G"," Tscherter A"," Costa C"," Mercuri NB"," Bernardi G"," Shen J"," Calabresi P."],"journal":"Neurobiology of disease","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16624565","id":"16624565","citationCount":23,"stringAuthors":"Pisani A,  Martella G,  Tscherter A,  Costa C,  Mercuri NB,  Bernardi G,  Shen J,  Calabresi P."}},{"resource":"22898350","link":"http://www.ncbi.nlm.nih.gov/pubmed/22898350","type":"PUBMED","article":{"title":"DJ-1 protects dopaminergic neurons against rotenone-induced apoptosis by enhancing ERK-dependent mitophagy.","authors":["Gao H"," Yang W"," Qi Z"," Lu L"," Duan C"," Zhao C"," Yang H."],"journal":"Journal of molecular biology","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22898350","id":"22898350","citationCount":21,"stringAuthors":"Gao H,  Yang W,  Qi Z,  Lu L,  Duan C,  Zhao C,  Yang H."}},{"resource":"19063952","link":"http://www.ncbi.nlm.nih.gov/pubmed/19063952","type":"PUBMED","article":{"title":"Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes.","authors":["Ashley AK"," Hanneman WH"," Katoh T"," Moreno JA"," Pollack A"," Tjalkens RB"," Legare ME."],"journal":"Toxicology letters","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19063952","id":"19063952","citationCount":15,"stringAuthors":"Ashley AK,  Hanneman WH,  Katoh T,  Moreno JA,  Pollack A,  Tjalkens RB,  Legare ME."}}],"name":"PARK7","targetParticipants":[{"resource":"PARK7","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PARK7","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"20940149","link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","type":"PUBMED","article":{"title":"DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.","authors":["Thomas KJ"," McCoy MK"," Blackinton J"," Beilina A"," van der Brug M"," Sandebring A"," Miller D"," Maric D"," Cedazo-Minguez A"," Cookson MR."],"journal":"Human molecular genetics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","id":"20940149","citationCount":148,"stringAuthors":"Thomas KJ,  McCoy MK,  Blackinton J,  Beilina A,  van der Brug M,  Sandebring A,  Miller D,  Maric D,  Cedazo-Minguez A,  Cookson MR."}},{"resource":"19492085","link":"http://www.ncbi.nlm.nih.gov/pubmed/19492085","type":"PUBMED","article":{"title":"Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.","authors":["Sandebring A"," Thomas KJ"," Beilina A"," van der Brug M"," Cleland MM"," Ahmad R"," Miller DW"," Zambrano I"," Cowburn RF"," Behbahani H"," Cedazo-Mínguez A"," Cookson MR."],"journal":"PloS one","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19492085","id":"19492085","citationCount":93,"stringAuthors":"Sandebring A,  Thomas KJ,  Beilina A,  van der Brug M,  Cleland MM,  Ahmad R,  Miller DW,  Zambrano I,  Cowburn RF,  Behbahani H,  Cedazo-Mínguez A,  Cookson MR."}},{"resource":"16226715","link":"http://www.ncbi.nlm.nih.gov/pubmed/16226715","type":"PUBMED","article":{"title":"Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y.","authors":["Deng H"," Jankovic J"," Guo Y"," Xie W"," Le W."],"journal":"Biochemical and biophysical research communications","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16226715","id":"16226715","citationCount":72,"stringAuthors":"Deng H,  Jankovic J,  Guo Y,  Xie W,  Le W."}},{"resource":"21421046","link":"http://www.ncbi.nlm.nih.gov/pubmed/21421046","type":"PUBMED","article":{"title":"PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons.","authors":["Wang HL"," Chou AH"," Wu AS"," Chen SY"," Weng YH"," Kao YC"," Yeh TH"," Chu PJ"," Lu CS."],"journal":"Biochimica et biophysica acta","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21421046","id":"21421046","citationCount":40,"stringAuthors":"Wang HL,  Chou AH,  Wu AS,  Chen SY,  Weng YH,  Kao YC,  Yeh TH,  Chu PJ,  Lu CS."}},{"resource":"20464527","link":"http://www.ncbi.nlm.nih.gov/pubmed/20464527","type":"PUBMED","article":{"title":"α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment.","authors":["George S"," Mok SS"," Nurjono M"," Ayton S"," Finkelstein DI"," Masters CL"," Li QX"," Culvenor JG."],"journal":"Journal of molecular neuroscience : MN","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20464527","id":"20464527","citationCount":14,"stringAuthors":"George S,  Mok SS,  Nurjono M,  Ayton S,  Finkelstein DI,  Masters CL,  Li QX,  Culvenor JG."}}],"name":"PINK1","targetParticipants":[{"resource":"PINK1","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PINK1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"20940149","link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","type":"PUBMED","article":{"title":"DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.","authors":["Thomas KJ"," McCoy MK"," Blackinton J"," Beilina A"," van der Brug M"," Sandebring A"," Miller D"," Maric D"," Cedazo-Minguez A"," Cookson MR."],"journal":"Human molecular genetics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","id":"20940149","citationCount":148,"stringAuthors":"Thomas KJ,  McCoy MK,  Blackinton J,  Beilina A,  van der Brug M,  Sandebring A,  Miller D,  Maric D,  Cedazo-Minguez A,  Cookson MR."}},{"resource":"19741132","link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","type":"PUBMED","article":{"title":"Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.","authors":["Ng CH"," Mok SZ"," Koh C"," Ouyang X"," Fivaz ML"," Tan EK"," Dawson VL"," Dawson TM"," Yu F"," Lim KL."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","id":"19741132","citationCount":90,"stringAuthors":"Ng CH,  Mok SZ,  Koh C,  Ouyang X,  Fivaz ML,  Tan EK,  Dawson VL,  Dawson TM,  Yu F,  Lim KL."}},{"resource":"16573651","link":"http://www.ncbi.nlm.nih.gov/pubmed/16573651","type":"PUBMED","article":{"title":"Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline.","authors":["Casarejos MJ"," Menéndez J"," Solano RM"," Rodríguez-Navarro JA"," García de Yébenes J"," Mena MA."],"journal":"Journal of neurochemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16573651","id":"16573651","citationCount":66,"stringAuthors":"Casarejos MJ,  Menéndez J,  Solano RM,  Rodríguez-Navarro JA,  García de Yébenes J,  Mena MA."}},{"resource":"22872702","link":"http://www.ncbi.nlm.nih.gov/pubmed/22872702","type":"PUBMED","article":{"title":"ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons.","authors":["Joselin AP"," Hewitt SJ"," Callaghan SM"," Kim RH"," Chung YH"," Mak TW"," Shen J"," Slack RS"," Park DS."],"journal":"Human molecular genetics","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22872702","id":"22872702","citationCount":59,"stringAuthors":"Joselin AP,  Hewitt SJ,  Callaghan SM,  Kim RH,  Chung YH,  Mak TW,  Shen J,  Slack RS,  Park DS."}},{"resource":"17687034","link":"http://www.ncbi.nlm.nih.gov/pubmed/17687034","type":"PUBMED","article":{"title":"Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities.","authors":["Wang C"," Lu R"," Ouyang X"," Ho MW"," Chia W"," Yu F"," Lim KL."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17687034","id":"17687034","citationCount":52,"stringAuthors":"Wang C,  Lu R,  Ouyang X,  Ho MW,  Chia W,  Yu F,  Lim KL."}},{"resource":"16517603","link":"http://www.ncbi.nlm.nih.gov/pubmed/16517603","type":"PUBMED","article":{"title":"Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells.","authors":["Rosen KM"," Veereshwarayya V"," Moussa CE"," Fu Q"," Goldberg MS"," Schlossmacher MG"," Shen J"," Querfurth HW."],"journal":"The Journal of Biological Chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16517603","id":"16517603","citationCount":45,"stringAuthors":"Rosen KM,  Veereshwarayya V,  Moussa CE,  Fu Q,  Goldberg MS,  Schlossmacher MG,  Shen J,  Querfurth HW."}}],"name":"PRKN","targetParticipants":[{"resource":"PRKN","link":null,"id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"21383081","link":"http://www.ncbi.nlm.nih.gov/pubmed/21383081","type":"PUBMED","article":{"title":"Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson's disease model.","authors":["Choi WS"," Palmiter RD"," Xia Z."],"journal":"The Journal of cell biology","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21383081","id":"21383081","citationCount":65,"stringAuthors":"Choi WS,  Palmiter RD,  Xia Z."}},{"resource":"18579341","link":"http://www.ncbi.nlm.nih.gov/pubmed/18579341","type":"PUBMED","article":{"title":"Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism.","authors":["Sai Y"," Wu Q"," Le W"," Ye F"," Li Y"," Dong Z."],"journal":"Toxicology in vitro : an international journal published in association with BIBRA","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18579341","id":"18579341","citationCount":27,"stringAuthors":"Sai Y,  Wu Q,  Le W,  Ye F,  Li Y,  Dong Z."}},{"resource":"26276080","link":"http://www.ncbi.nlm.nih.gov/pubmed/26276080","type":"PUBMED","article":{"title":"Pyrroloquinoline quinone-conferred neuroprotection in rotenone models of Parkinson's disease.","authors":["Qin J"," Wu M"," Yu S"," Gao X"," Zhang J"," Dong X"," Ji J"," Zhang Y"," Zhou L"," Zhang Q"," Ding F."],"journal":"Toxicology letters","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26276080","id":"26276080","citationCount":3,"stringAuthors":"Qin J,  Wu M,  Yu S,  Gao X,  Zhang J,  Dong X,  Ji J,  Zhang Y,  Zhou L,  Zhang Q,  Ding F."}},{"resource":"25496994","link":"http://www.ncbi.nlm.nih.gov/pubmed/25496994","type":"PUBMED","article":{"title":"JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death.","authors":["Choi WS"," Kim HW"," Xia Z."],"journal":"Toxicology","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25496994","id":"25496994","citationCount":2,"stringAuthors":"Choi WS,  Kim HW,  Xia Z."}}],"name":"SLC18A2","targetParticipants":[{"resource":"SLC18A2","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SLC18A2","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"18289173","link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","type":"PUBMED","article":{"title":"Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats.","authors":["Lin CH"," Huang JY"," Ching CH"," Chuang JI."],"journal":"Journal of pineal research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","id":"18289173","citationCount":32,"stringAuthors":"Lin CH,  Huang JY,  Ching CH,  Chuang JI."}},{"resource":"18579341","link":"http://www.ncbi.nlm.nih.gov/pubmed/18579341","type":"PUBMED","article":{"title":"Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism.","authors":["Sai Y"," Wu Q"," Le W"," Ye F"," Li Y"," Dong Z."],"journal":"Toxicology in vitro : an international journal published in association with BIBRA","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18579341","id":"18579341","citationCount":27,"stringAuthors":"Sai Y,  Wu Q,  Le W,  Ye F,  Li Y,  Dong Z."}},{"resource":"23567316","link":"http://www.ncbi.nlm.nih.gov/pubmed/23567316","type":"PUBMED","article":{"title":"Neonatal exposure to lipopolysaccharide enhances accumulation of α-synuclein aggregation and dopamine transporter protein expression in the substantia nigra in responses to rotenone challenge in later life.","authors":["Tien LT"," Kaizaki A"," Pang Y"," Cai Z"," Bhatt AJ"," Fan LW."],"journal":"Toxicology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23567316","id":"23567316","citationCount":6,"stringAuthors":"Tien LT,  Kaizaki A,  Pang Y,  Cai Z,  Bhatt AJ,  Fan LW."}},{"resource":"18206288","link":"http://www.ncbi.nlm.nih.gov/pubmed/18206288","type":"PUBMED","article":{"title":"The role of dopamine transporter in selective toxicity of manganese and rotenone.","authors":["Hirata Y"," Suzuno H"," Tsuruta T"," Oh-hashi K"," Kiuchi K."],"journal":"Toxicology","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18206288","id":"18206288","citationCount":4,"stringAuthors":"Hirata Y,  Suzuno H,  Tsuruta T,  Oh-hashi K,  Kiuchi K."}}],"name":"SLC6A3","targetParticipants":[{"resource":"SLC6A3","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SLC6A3","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"11100151","link":"http://www.ncbi.nlm.nih.gov/pubmed/11100151","type":"PUBMED","article":{"title":"Chronic systemic pesticide exposure reproduces features of Parkinson's disease.","authors":["Betarbet R"," Sherer TB"," MacKenzie G"," Garcia-Osuna M"," Panov AV"," Greenamyre JT."],"journal":"Nature neuroscience","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11100151","id":"11100151","citationCount":1330,"stringAuthors":"Betarbet R,  Sherer TB,  MacKenzie G,  Garcia-Osuna M,  Panov AV,  Greenamyre JT."}},{"resource":"12177198","link":"http://www.ncbi.nlm.nih.gov/pubmed/12177198","type":"PUBMED","article":{"title":"An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.","authors":["Sherer TB"," Betarbet R"," Stout AK"," Lund S"," Baptista M"," Panov AV"," Cookson MR"," Greenamyre JT."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12177198","id":"12177198","citationCount":240,"stringAuthors":"Sherer TB,  Betarbet R,  Stout AK,  Lund S,  Baptista M,  Panov AV,  Cookson MR,  Greenamyre JT."}},{"resource":"16439141","link":"http://www.ncbi.nlm.nih.gov/pubmed/16439141","type":"PUBMED","article":{"title":"Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system.","authors":["Betarbet R"," Canet-Aviles RM"," Sherer TB"," Mastroberardino PG"," McLendon C"," Kim JH"," Lund S"," Na HM"," Taylor G"," Bence NF"," Kopito R"," Seo BB"," Yagi T"," Yagi A"," Klinefelter G"," Cookson MR"," Greenamyre JT."],"journal":"Neurobiology of disease","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16439141","id":"16439141","citationCount":131,"stringAuthors":"Betarbet R,  Canet-Aviles RM,  Sherer TB,  Mastroberardino PG,  McLendon C,  Kim JH,  Lund S,  Na HM,  Taylor G,  Bence NF,  Kopito R,  Seo BB,  Yagi T,  Yagi A,  Klinefelter G,  Cookson MR,  Greenamyre JT."}},{"resource":"11445065","link":"http://www.ncbi.nlm.nih.gov/pubmed/11445065","type":"PUBMED","article":{"title":"Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease.","authors":["Uversky VN"," Li J"," Fink AL."],"journal":"FEBS letters","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11445065","id":"11445065","citationCount":124,"stringAuthors":"Uversky VN,  Li J,  Fink AL."}},{"resource":"16239214","link":"http://www.ncbi.nlm.nih.gov/pubmed/16239214","type":"PUBMED","article":{"title":"Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.","authors":["Ved R"," Saha S"," Westlund B"," Perier C"," Burnam L"," Sluder A"," Hoener M"," Rodrigues CM"," Alfonso A"," Steer C"," Liu L"," Przedborski S"," Wolozin B."],"journal":"The Journal of biological chemistry","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16239214","id":"16239214","citationCount":120,"stringAuthors":"Ved R,  Saha S,  Westlund B,  Perier C,  Burnam L,  Sluder A,  Hoener M,  Rodrigues CM,  Alfonso A,  Steer C,  Liu L,  Przedborski S,  Wolozin B."}},{"resource":"24290359","link":"http://www.ncbi.nlm.nih.gov/pubmed/24290359","type":"PUBMED","article":{"title":"Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.","authors":["Ryan SD"," Dolatabadi N"," Chan SF"," Zhang X"," Akhtar MW"," Parker J"," Soldner F"," Sunico CR"," Nagar S"," Talantova M"," Lee B"," Lopez K"," Nutter A"," Shan B"," Molokanova E"," Zhang Y"," Han X"," Nakamura T"," Masliah E"," Yates JR"," Nakanishi N"," Andreyev AY"," Okamoto S"," Jaenisch R"," Ambasudhan R"," Lipton SA."],"journal":"Cell","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24290359","id":"24290359","citationCount":88,"stringAuthors":"Ryan SD,  Dolatabadi N,  Chan SF,  Zhang X,  Akhtar MW,  Parker J,  Soldner F,  Sunico CR,  Nagar S,  Talantova M,  Lee B,  Lopez K,  Nutter A,  Shan B,  Molokanova E,  Zhang Y,  Han X,  Nakamura T,  Masliah E,  Yates JR,  Nakanishi N,  Andreyev AY,  Okamoto S,  Jaenisch R,  Ambasudhan R,  Lipton SA."}},{"resource":"16219024","link":"http://www.ncbi.nlm.nih.gov/pubmed/16219024","type":"PUBMED","article":{"title":"The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy.","authors":["Höglinger GU"," Lannuzel A"," Khondiker ME"," Michel PP"," Duyckaerts C"," Féger J"," Champy P"," Prigent A"," Medja F"," Lombes A"," Oertel WH"," Ruberg M"," Hirsch EC."],"journal":"Journal of neurochemistry","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16219024","id":"16219024","citationCount":76,"stringAuthors":"Höglinger GU,  Lannuzel A,  Khondiker ME,  Michel PP,  Duyckaerts C,  Féger J,  Champy P,  Prigent A,  Medja F,  Lombes A,  Oertel WH,  Ruberg M,  Hirsch EC."}},{"resource":"23205266","link":"http://www.ncbi.nlm.nih.gov/pubmed/23205266","type":"PUBMED","article":{"title":"Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice.","authors":["Pan-Montojo F"," Schwarz M"," Winkler C"," Arnhold M"," O'Sullivan GA"," Pal A"," Said J"," Marsico G"," Verbavatz JM"," Rodrigo-Angulo M"," Gille G"," Funk RH"," Reichmann H."],"journal":"Scientific reports","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23205266","id":"23205266","citationCount":71,"stringAuthors":"Pan-Montojo F,  Schwarz M,  Winkler C,  Arnhold M,  O'Sullivan GA,  Pal A,  Said J,  Marsico G,  Verbavatz JM,  Rodrigo-Angulo M,  Gille G,  Funk RH,  Reichmann H."}},{"resource":"17459145","link":"http://www.ncbi.nlm.nih.gov/pubmed/17459145","type":"PUBMED","article":{"title":"Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.","authors":["Inden M"," Kitamura Y"," Takeuchi H"," Yanagida T"," Takata K"," Kobayashi Y"," Taniguchi T"," Yoshimoto K"," Kaneko M"," Okuma Y"," Taira T"," Ariga H"," Shimohama S."],"journal":"Journal of neurochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17459145","id":"17459145","citationCount":68,"stringAuthors":"Inden M,  Kitamura Y,  Takeuchi H,  Yanagida T,  Takata K,  Kobayashi Y,  Taniguchi T,  Yoshimoto K,  Kaneko M,  Okuma Y,  Taira T,  Ariga H,  Shimohama S."}},{"resource":"19628769","link":"http://www.ncbi.nlm.nih.gov/pubmed/19628769","type":"PUBMED","article":{"title":"Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein.","authors":["Yu WH"," Dorado B"," Figueroa HY"," Wang L"," Planel E"," Cookson MR"," Clark LN"," Duff KE."],"journal":"The American journal of pathology","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19628769","id":"19628769","citationCount":65,"stringAuthors":"Yu WH,  Dorado B,  Figueroa HY,  Wang L,  Planel E,  Cookson MR,  Clark LN,  Duff KE."}},{"resource":"18514418","link":"http://www.ncbi.nlm.nih.gov/pubmed/18514418","type":"PUBMED","article":{"title":"Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells.","authors":["Shavali S"," Brown-Borg HM"," Ebadi M"," Porter J."],"journal":"Neuroscience letters","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18514418","id":"18514418","citationCount":62,"stringAuthors":"Shavali S,  Brown-Borg HM,  Ebadi M,  Porter J."}},{"resource":"17131421","link":"http://www.ncbi.nlm.nih.gov/pubmed/17131421","type":"PUBMED","article":{"title":"RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport.","authors":["Fountaine TM"," Wade-Martins R."],"journal":"Journal of neuroscience research","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17131421","id":"17131421","citationCount":56,"stringAuthors":"Fountaine TM,  Wade-Martins R."}},{"resource":"19626387","link":"http://www.ncbi.nlm.nih.gov/pubmed/19626387","type":"PUBMED","article":{"title":"Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synuclein.","authors":["Monti B"," Gatta V"," Piretti F"," Raffaelli SS"," Virgili M"," Contestabile A."],"journal":"Neurotoxicity research","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19626387","id":"19626387","citationCount":49,"stringAuthors":"Monti B,  Gatta V,  Piretti F,  Raffaelli SS,  Virgili M,  Contestabile A."}},{"resource":"15099020","link":"http://www.ncbi.nlm.nih.gov/pubmed/15099020","type":"PUBMED","article":{"title":"Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice.","authors":["Dalfó E"," Gómez-Isla T"," Rosa JL"," Nieto Bodelón M"," Cuadrado Tejedor M"," Barrachina M"," Ambrosio S"," Ferrer I."],"journal":"Journal of neuropathology and experimental neurology","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15099020","id":"15099020","citationCount":45,"stringAuthors":"Dalfó E,  Gómez-Isla T,  Rosa JL,  Nieto Bodelón M,  Cuadrado Tejedor M,  Barrachina M,  Ambrosio S,  Ferrer I."}},{"resource":"19114014","link":"http://www.ncbi.nlm.nih.gov/pubmed/19114014","type":"PUBMED","article":{"title":"Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells.","authors":["Borland MK"," Trimmer PA"," Rubinstein JD"," Keeney PM"," Mohanakumar K"," Liu L"," Bennett JP."],"journal":"Molecular neurodegeneration","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19114014","id":"19114014","citationCount":44,"stringAuthors":"Borland MK,  Trimmer PA,  Rubinstein JD,  Keeney PM,  Mohanakumar K,  Liu L,  Bennett JP."}},{"resource":"18289173","link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","type":"PUBMED","article":{"title":"Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats.","authors":["Lin CH"," Huang JY"," Ching CH"," Chuang JI."],"journal":"Journal of pineal research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","id":"18289173","citationCount":32,"stringAuthors":"Lin CH,  Huang JY,  Ching CH,  Chuang JI."}},{"resource":"15280438","link":"http://www.ncbi.nlm.nih.gov/pubmed/15280438","type":"PUBMED","article":{"title":"Rotenone induces apoptosis via activation of bad in human dopaminergic SH-SY5Y cells.","authors":["Watabe M"," Nakaki T."],"journal":"The Journal of pharmacology and experimental therapeutics","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15280438","id":"15280438","citationCount":27,"stringAuthors":"Watabe M,  Nakaki T."}},{"resource":"15114628","link":"http://www.ncbi.nlm.nih.gov/pubmed/15114628","type":"PUBMED","article":{"title":"1-Benzyl-1,2,3,4-tetrahydroisoquinoline, a Parkinsonism-inducing endogenous toxin, increases alpha-synuclein expression and causes nuclear damage in human dopaminergic cells.","authors":["Shavali S"," Carlson EC"," Swinscoe JC"," Ebadi M."],"journal":"Journal of neuroscience research","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15114628","id":"15114628","citationCount":23,"stringAuthors":"Shavali S,  Carlson EC,  Swinscoe JC,  Ebadi M."}},{"resource":"19857570","link":"http://www.ncbi.nlm.nih.gov/pubmed/19857570","type":"PUBMED","article":{"title":"Oxidants induce alternative splicing of alpha-synuclein: Implications for Parkinson's disease.","authors":["Kalivendi SV"," Yedlapudi D"," Hillard CJ"," Kalyanaraman B."],"journal":"Free radical biology & medicine","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19857570","id":"19857570","citationCount":22,"stringAuthors":"Kalivendi SV,  Yedlapudi D,  Hillard CJ,  Kalyanaraman B."}},{"resource":"20414966","link":"http://www.ncbi.nlm.nih.gov/pubmed/20414966","type":"PUBMED","article":{"title":"Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease.","authors":["Zhang H"," Jia H"," Liu J"," Ao N"," Yan B"," Shen W"," Wang X"," Li X"," Luo C"," Liu J."],"journal":"Journal of cellular and molecular medicine","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20414966","id":"20414966","citationCount":21,"stringAuthors":"Zhang H,  Jia H,  Liu J,  Ao N,  Yan B,  Shen W,  Wang X,  Li X,  Luo C,  Liu J."}},{"resource":"23153578","link":"http://www.ncbi.nlm.nih.gov/pubmed/23153578","type":"PUBMED","article":{"title":"Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment.","authors":["Cannon JR"," Geghman KD"," Tapias V"," Sew T"," Dail MK"," Li C"," Greenamyre JT."],"journal":"Experimental neurology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23153578","id":"23153578","citationCount":17,"stringAuthors":"Cannon JR,  Geghman KD,  Tapias V,  Sew T,  Dail MK,  Li C,  Greenamyre JT."}},{"resource":"20464527","link":"http://www.ncbi.nlm.nih.gov/pubmed/20464527","type":"PUBMED","article":{"title":"α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment.","authors":["George S"," Mok SS"," Nurjono M"," Ayton S"," Finkelstein DI"," Masters CL"," Li QX"," Culvenor JG."],"journal":"Journal of molecular neuroscience : MN","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20464527","id":"20464527","citationCount":14,"stringAuthors":"George S,  Mok SS,  Nurjono M,  Ayton S,  Finkelstein DI,  Masters CL,  Li QX,  Culvenor JG."}},{"resource":"12151787","link":"http://www.ncbi.nlm.nih.gov/pubmed/12151787","type":"PUBMED","article":{"title":"Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro.","authors":["Lehmensiek V"," Tan EM"," Schwarz J"," Storch A."],"journal":"Neuroreport","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12151787","id":"12151787","citationCount":13,"stringAuthors":"Lehmensiek V,  Tan EM,  Schwarz J,  Storch A."}},{"resource":"23535362","link":"http://www.ncbi.nlm.nih.gov/pubmed/23535362","type":"PUBMED","article":{"title":"Specific pesticide-dependent increases in α-synuclein levels in human neuroblastoma (SH-SY5Y) and melanoma (SK-MEL-2) cell lines.","authors":["Chorfa A"," Bétemps D"," Morignat E"," Lazizzera C"," Hogeveen K"," Andrieu T"," Baron T."],"journal":"Toxicological sciences : an official journal of the Society of Toxicology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23535362","id":"23535362","citationCount":11,"stringAuthors":"Chorfa A,  Bétemps D,  Morignat E,  Lazizzera C,  Hogeveen K,  Andrieu T,  Baron T."}},{"resource":"26075822","link":"http://www.ncbi.nlm.nih.gov/pubmed/26075822","type":"PUBMED","article":{"title":"shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model.","authors":["Zharikov AD"," Cannon JR"," Tapias V"," Bai Q"," Horowitz MP"," Shah V"," El Ayadi A"," Hastings TG"," Greenamyre JT"," Burton EA."],"journal":"The Journal of clinical investigation","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26075822","id":"26075822","citationCount":9,"stringAuthors":"Zharikov AD,  Cannon JR,  Tapias V,  Bai Q,  Horowitz MP,  Shah V,  El Ayadi A,  Hastings TG,  Greenamyre JT,  Burton EA."}},{"resource":"23984410","link":"http://www.ncbi.nlm.nih.gov/pubmed/23984410","type":"PUBMED","article":{"title":"Rotenone upregulates alpha-synuclein and myocyte enhancer factor 2D independently from lysosomal degradation inhibition.","authors":["Sala G"," Arosio A"," Stefanoni G"," Melchionda L"," Riva C"," Marinig D"," Brighina L"," Ferrarese C."],"journal":"BioMed Research International","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23984410","id":"23984410","citationCount":8,"stringAuthors":"Sala G,  Arosio A,  Stefanoni G,  Melchionda L,  Riva C,  Marinig D,  Brighina L,  Ferrarese C."}},{"resource":"17690729","link":"http://www.ncbi.nlm.nih.gov/pubmed/17690729","type":"PUBMED","article":{"title":"alpha-Synuclein redistributed and aggregated in rotenone-induced Parkinson's disease rats.","authors":["Feng Y"," Liang ZH"," Wang T"," Qiao X"," Liu HJ"," Sun SG."],"journal":"Neuroscience bulletin","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17690729","id":"17690729","citationCount":8,"stringAuthors":"Feng Y,  Liang ZH,  Wang T,  Qiao X,  Liu HJ,  Sun SG."}},{"resource":"25433145","link":"http://www.ncbi.nlm.nih.gov/pubmed/25433145","type":"PUBMED","article":{"title":"The molecular mechanism of rotenone-induced α-synuclein aggregation: emphasizing the role of the calcium/GSK3β pathway.","authors":["Yuan YH"," Yan WF"," Sun JD"," Huang JY"," Mu Z"," Chen NH."],"journal":"Toxicology letters","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25433145","id":"25433145","citationCount":8,"stringAuthors":"Yuan YH,  Yan WF,  Sun JD,  Huang JY,  Mu Z,  Chen NH."}},{"resource":"26031332","link":"http://www.ncbi.nlm.nih.gov/pubmed/26031332","type":"PUBMED","article":{"title":"Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation.","authors":["Hou YS"," Guan JJ"," Xu HD"," Wu F"," Sheng R"," Qin ZH."],"journal":"Molecular and cellular biology","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26031332","id":"26031332","citationCount":5,"stringAuthors":"Hou YS,  Guan JJ,  Xu HD,  Wu F,  Sheng R,  Qin ZH."}},{"resource":"23244436","link":"http://www.ncbi.nlm.nih.gov/pubmed/23244436","type":"PUBMED","article":{"title":"Environmental toxicants as extrinsic epigenetic factors for parkinsonism: studies employing transgenic C. elegans model.","authors":["Jadiya P"," Nazir A."],"journal":"CNS & neurological disorders drug targets","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23244436","id":"23244436","citationCount":5,"stringAuthors":"Jadiya P,  Nazir A."}},{"resource":"25430725","link":"http://www.ncbi.nlm.nih.gov/pubmed/25430725","type":"PUBMED","article":{"title":"Daily rhythms of serotonin metabolism and the expression of clock genes in suprachiasmatic nucleus of rotenone-induced Parkinson's disease male Wistar rat model and effect of melatonin administration.","authors":["Mattam U"," Jagota A."],"journal":"Biogerontology","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25430725","id":"25430725","citationCount":3,"stringAuthors":"Mattam U,  Jagota A."}},{"resource":"27133439","link":"http://www.ncbi.nlm.nih.gov/pubmed/27133439","type":"PUBMED","article":{"title":"Rotenone down-regulates HSPA8/hsc70 chaperone protein in vitro: A new possible toxic mechanism contributing to Parkinson's disease.","authors":["Sala G"," Marinig D"," Riva C"," Arosio A"," Stefanoni G"," Brighina L"," Formenti M"," Alberghina L"," Colangelo AM"," Ferrarese C."],"journal":"Neurotoxicology","year":2016,"link":"http://www.ncbi.nlm.nih.gov/pubmed/27133439","id":"27133439","citationCount":2,"stringAuthors":"Sala G,  Marinig D,  Riva C,  Arosio A,  Stefanoni G,  Brighina L,  Formenti M,  Alberghina L,  Colangelo AM,  Ferrarese C."}},{"resource":"24002177","link":"http://www.ncbi.nlm.nih.gov/pubmed/24002177","type":"PUBMED","article":{"title":"14-3-3 Proteins in the regulation of rotenone-induced neurotoxicity might be via its isoform 14-3-3epsilon's involvement in autophagy.","authors":["Sai Y"," Peng K"," Ye F"," Zhao X"," Zhao Y"," Zou Z"," Cao J"," Dong Z."],"journal":"Cellular and molecular neurobiology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24002177","id":"24002177","citationCount":1,"stringAuthors":"Sai Y,  Peng K,  Ye F,  Zhao X,  Zhao Y,  Zou Z,  Cao J,  Dong Z."}},{"resource":"17041725","link":"http://www.ncbi.nlm.nih.gov/pubmed/17041725","type":"PUBMED","article":{"title":"[Overexpression of alpha-synuclein in SH-SY5Y cells partially protected against oxidative stress induced by rotenone].","authors":["Liu YY"," Zhao HY"," Zhao CL"," Duan CL"," Lu LL"," Yang H."],"journal":"Sheng li xue bao : [Acta physiologica Sinica]","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17041725","id":"17041725","citationCount":0,"stringAuthors":"Liu YY,  Zhao HY,  Zhao CL,  Duan CL,  Lu LL,  Yang H."}}],"name":"SNCA","targetParticipants":[{"resource":"SNCA","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SNCA","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"17079513","link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","type":"PUBMED","article":{"title":"Microtubule: a common target for parkin and Parkinson's disease toxins.","authors":["Feng J."],"journal":"The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","id":"17079513","citationCount":34,"stringAuthors":"Feng J."}},{"resource":"17070561","link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","type":"PUBMED","article":{"title":"Standardized Hypericum perforatum reduces oxidative stress and increases gene expression of antioxidant enzymes on rotenone-exposed rats.","authors":["Sánchez-Reus MI"," Gómez del Rio MA"," Iglesias I"," Elorza M"," Slowing K"," Benedí J."],"journal":"Neuropharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","id":"17070561","citationCount":21,"stringAuthors":"Sánchez-Reus MI,  Gómez del Rio MA,  Iglesias I,  Elorza M,  Slowing K,  Benedí J."}},{"resource":"23639798","link":"http://www.ncbi.nlm.nih.gov/pubmed/23639798","type":"PUBMED","article":{"title":"Valeriana officinalis attenuates the rotenone-induced toxicity in Drosophila melanogaster.","authors":["Sudati JH"," Vieira FA"," Pavin SS"," Dias GR"," Seeger RL"," Golombieski R"," Athayde ML"," Soares FA"," Rocha JB"," Barbosa NV."],"journal":"Neurotoxicology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23639798","id":"23639798","citationCount":17,"stringAuthors":"Sudati JH,  Vieira FA,  Pavin SS,  Dias GR,  Seeger RL,  Golombieski R,  Athayde ML,  Soares FA,  Rocha JB,  Barbosa NV."}},{"resource":"17657281","link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","type":"PUBMED","article":{"title":"The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.","authors":["Panee J"," Liu W"," Nakamura K"," Berry MJ."],"journal":"International journal of biological sciences","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":"17657281","citationCount":13,"stringAuthors":"Panee J,  Liu W,  Nakamura K,  Berry MJ."}},{"resource":"24374061","link":"http://www.ncbi.nlm.nih.gov/pubmed/24374061","type":"PUBMED","article":{"title":"PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1.","authors":["Corona JC"," de Souza SC"," Duchen MR."],"journal":"Experimental neurology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24374061","id":"24374061","citationCount":12,"stringAuthors":"Corona JC,  de Souza SC,  Duchen MR."}},{"resource":"21807080","link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","type":"PUBMED","article":{"title":"An effective novel delivery strategy of rasagiline for Parkinson's disease.","authors":["Fernández M"," Negro S"," Slowing K"," Fernández-Carballido A"," Barcia E."],"journal":"International journal of pharmaceutics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","id":"21807080","citationCount":8,"stringAuthors":"Fernández M,  Negro S,  Slowing K,  Fernández-Carballido A,  Barcia E."}},{"resource":"22447502","link":"http://www.ncbi.nlm.nih.gov/pubmed/22447502","type":"PUBMED","article":{"title":"Molecular responses differ between sensitive silver carp and tolerant bighead carp and bigmouth buffalo exposed to rotenone.","authors":["Amberg JJ"," Schreier TM"," Gaikowski MP."],"journal":"Fish physiology and biochemistry","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22447502","id":"22447502","citationCount":3,"stringAuthors":"Amberg JJ,  Schreier TM,  Gaikowski MP."}}],"name":"SOD1","targetParticipants":[{"resource":"SOD1","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SOD1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"18032788","link":"http://www.ncbi.nlm.nih.gov/pubmed/18032788","type":"PUBMED","article":{"title":"Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species.","authors":["Chen Y"," McMillan-Ward E"," Kong J"," Israels SJ"," Gibson SB."],"journal":"Journal of cell science","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18032788","id":"18032788","citationCount":167,"stringAuthors":"Chen Y,  McMillan-Ward E,  Kong J,  Israels SJ,  Gibson SB."}},{"resource":"16179351","link":"http://www.ncbi.nlm.nih.gov/pubmed/16179351","type":"PUBMED","article":{"title":"Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress.","authors":["Hu Y"," Rosen DG"," Zhou Y"," Feng L"," Yang G"," Liu J"," Huang P."],"journal":"The Journal of biological chemistry","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16179351","id":"16179351","citationCount":103,"stringAuthors":"Hu Y,  Rosen DG,  Zhou Y,  Feng L,  Yang G,  Liu J,  Huang P."}},{"resource":"10463952","link":"http://www.ncbi.nlm.nih.gov/pubmed/10463952","type":"PUBMED","article":{"title":"Overexpression of manganese superoxide dismutase protects against mitochondrial-initiated poly(ADP-ribose) polymerase-mediated cell death.","authors":["Kiningham KK"," Oberley TD"," Lin S"," Mattingly CA"," St Clair DK."],"journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10463952","id":"10463952","citationCount":48,"stringAuthors":"Kiningham KK,  Oberley TD,  Lin S,  Mattingly CA,  St Clair DK."}},{"resource":"17079513","link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","type":"PUBMED","article":{"title":"Microtubule: a common target for parkin and Parkinson's disease toxins.","authors":["Feng J."],"journal":"The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","id":"17079513","citationCount":34,"stringAuthors":"Feng J."}},{"resource":"17070561","link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","type":"PUBMED","article":{"title":"Standardized Hypericum perforatum reduces oxidative stress and increases gene expression of antioxidant enzymes on rotenone-exposed rats.","authors":["Sánchez-Reus MI"," Gómez del Rio MA"," Iglesias I"," Elorza M"," Slowing K"," Benedí J."],"journal":"Neuropharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","id":"17070561","citationCount":21,"stringAuthors":"Sánchez-Reus MI,  Gómez del Rio MA,  Iglesias I,  Elorza M,  Slowing K,  Benedí J."}},{"resource":"15904944","link":"http://www.ncbi.nlm.nih.gov/pubmed/15904944","type":"PUBMED","article":{"title":"Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine.","authors":["Molina-Jiménez MF"," Sánchez-Reus MI"," Cascales M"," Andrés D"," Benedí J."],"journal":"Toxicology and applied pharmacology","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15904944","id":"15904944","citationCount":14,"stringAuthors":"Molina-Jiménez MF,  Sánchez-Reus MI,  Cascales M,  Andrés D,  Benedí J."}},{"resource":"17657281","link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","type":"PUBMED","article":{"title":"The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.","authors":["Panee J"," Liu W"," Nakamura K"," Berry MJ."],"journal":"International journal of biological sciences","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":"17657281","citationCount":13,"stringAuthors":"Panee J,  Liu W,  Nakamura K,  Berry MJ."}},{"resource":"21807080","link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","type":"PUBMED","article":{"title":"An effective novel delivery strategy of rasagiline for Parkinson's disease.","authors":["Fernández M"," Negro S"," Slowing K"," Fernández-Carballido A"," Barcia E."],"journal":"International journal of pharmaceutics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","id":"21807080","citationCount":8,"stringAuthors":"Fernández M,  Negro S,  Slowing K,  Fernández-Carballido A,  Barcia E."}},{"resource":"19818760","link":"http://www.ncbi.nlm.nih.gov/pubmed/19818760","type":"PUBMED","article":{"title":"Enhanced metallothionein gene expression induced by mitochondrial oxidative stress is reduced in phospholipid hydroperoxide glutathione peroxidase-overexpressed cells.","authors":["Kadota Y"," Suzuki S"," Ideta S"," Fukinbara Y"," Kawakami T"," Imai H"," Nakagawa Y"," Sato M."],"journal":"European journal of pharmacology","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19818760","id":"19818760","citationCount":7,"stringAuthors":"Kadota Y,  Suzuki S,  Ideta S,  Fukinbara Y,  Kawakami T,  Imai H,  Nakagawa Y,  Sato M."}},{"resource":"8989910","link":"http://www.ncbi.nlm.nih.gov/pubmed/8989910","type":"PUBMED","article":{"title":"Increased manganese superoxide dismutase activity, protein, and mRNA levels and concurrent induction of tumor necrosis factor alpha in radiation-initiated Syrian hamster cells.","authors":["Otero G"," Avila MA"," Emfietzoglou D"," Clerch LB"," Massaro D"," Notario V."],"journal":"Molecular carcinogenesis","year":1996,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8989910","id":"8989910","citationCount":7,"stringAuthors":"Otero G,  Avila MA,  Emfietzoglou D,  Clerch LB,  Massaro D,  Notario V."}},{"resource":"22447502","link":"http://www.ncbi.nlm.nih.gov/pubmed/22447502","type":"PUBMED","article":{"title":"Molecular responses differ between sensitive silver carp and tolerant bighead carp and bigmouth buffalo exposed to rotenone.","authors":["Amberg JJ"," Schreier TM"," Gaikowski MP."],"journal":"Fish physiology and biochemistry","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22447502","id":"22447502","citationCount":3,"stringAuthors":"Amberg JJ,  Schreier TM,  Gaikowski MP."}},{"resource":"25843018","link":"http://www.ncbi.nlm.nih.gov/pubmed/25843018","type":"PUBMED","article":{"title":"Pyrroloquinoline quinone (PQQ) producing Escherichia coli Nissle 1917 (EcN) alleviates age associated oxidative stress and hyperlipidemia, and improves mitochondrial function in ageing rats.","authors":["Singh AK"," Pandey SK"," Saha G"," Gattupalli NK."],"journal":"Experimental gerontology","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25843018","id":"25843018","citationCount":2,"stringAuthors":"Singh AK,  Pandey SK,  Saha G,  Gattupalli NK."}}],"name":"SOD2","targetParticipants":[{"resource":"SOD2","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SOD2","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"10878378","link":"http://www.ncbi.nlm.nih.gov/pubmed/10878378","type":"PUBMED","article":{"title":"Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin.","authors":["Chandel NS"," Trzyna WC"," McClintock DS"," Schumacker PT."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10878378","id":"10878378","citationCount":153,"stringAuthors":"Chandel NS,  Trzyna WC,  McClintock DS,  Schumacker PT."}},{"resource":"10973919","link":"http://www.ncbi.nlm.nih.gov/pubmed/10973919","type":"PUBMED","article":{"title":"Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by reactive oxygen species.","authors":["Deshpande SS"," Angkeow P"," Huang J"," Ozaki M"," Irani K."],"journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10973919","id":"10973919","citationCount":97,"stringAuthors":"Deshpande SS,  Angkeow P,  Huang J,  Ozaki M,  Irani K."}},{"resource":"7532384","link":"http://www.ncbi.nlm.nih.gov/pubmed/7532384","type":"PUBMED","article":{"title":"Regulation of hepatic nitric oxide synthase by reactive oxygen intermediates and glutathione.","authors":["Duval DL"," Sieg DJ"," Billings RE."],"journal":"Archives of biochemistry and biophysics","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7532384","id":"7532384","citationCount":35,"stringAuthors":"Duval DL,  Sieg DJ,  Billings RE."}},{"resource":"17356569","link":"http://www.ncbi.nlm.nih.gov/pubmed/17356569","type":"PUBMED","article":{"title":"Iptakalim alleviates rotenone-induced degeneration of dopaminergic neurons through inhibiting microglia-mediated neuroinflammation.","authors":["Zhou F"," Wu JY"," Sun XL"," Yao HH"," Ding JH"," Hu G."],"journal":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17356569","id":"17356569","citationCount":34,"stringAuthors":"Zhou F,  Wu JY,  Sun XL,  Yao HH,  Ding JH,  Hu G."}},{"resource":"19012619","link":"http://www.ncbi.nlm.nih.gov/pubmed/19012619","type":"PUBMED","article":{"title":"Opening of microglial K(ATP) channels inhibits rotenone-induced neuroinflammation.","authors":["Zhou F"," Yao HH"," Wu JY"," Ding JH"," Sun T"," Hu G."],"journal":"Journal of cellular and molecular medicine","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19012619","id":"19012619","citationCount":32,"stringAuthors":"Zhou F,  Yao HH,  Wu JY,  Ding JH,  Sun T,  Hu G."}},{"resource":"15135310","link":"http://www.ncbi.nlm.nih.gov/pubmed/15135310","type":"PUBMED","article":{"title":"Inverse gene expression patterns for macrophage activating hepatotoxicants and peroxisome proliferators in rat liver.","authors":["McMillian M"," Nie AY"," Parker JB"," Leone A"," Kemmerer M"," Bryant S"," Herlich J"," Yieh L"," Bittner A"," Liu X"," Wan J"," Johnson MD."],"journal":"Biochemical pharmacology","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15135310","id":"15135310","citationCount":27,"stringAuthors":"McMillian M,  Nie AY,  Parker JB,  Leone A,  Kemmerer M,  Bryant S,  Herlich J,  Yieh L,  Bittner A,  Liu X,  Wan J,  Johnson MD."}},{"resource":"17015749","link":"http://www.ncbi.nlm.nih.gov/pubmed/17015749","type":"PUBMED","article":{"title":"Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.","authors":["Nair AS"," Shishodia S"," Ahn KS"," Kunnumakkara AB"," Sethi G"," Aggarwal BB."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17015749","id":"17015749","citationCount":26,"stringAuthors":"Nair AS,  Shishodia S,  Ahn KS,  Kunnumakkara AB,  Sethi G,  Aggarwal BB."}},{"resource":"22623043","link":"http://www.ncbi.nlm.nih.gov/pubmed/22623043","type":"PUBMED","article":{"title":"Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice.","authors":["Kang HW"," Kim JM"," Cha MY"," Jung HC"," Song IS"," Kim JS."],"journal":"Digestive diseases and sciences","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22623043","id":"22623043","citationCount":18,"stringAuthors":"Kang HW,  Kim JM,  Cha MY,  Jung HC,  Song IS,  Kim JS."}},{"resource":"18841906","link":"http://www.ncbi.nlm.nih.gov/pubmed/18841906","type":"PUBMED","article":{"title":"Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression.","authors":["Dat NT"," Lee JH"," Lee K"," Hong YS"," Kim YH"," Lee JJ."],"journal":"Journal of natural products","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18841906","id":"18841906","citationCount":17,"stringAuthors":"Dat NT,  Lee JH,  Lee K,  Hong YS,  Kim YH,  Lee JJ."}},{"resource":"16257489","link":"http://www.ncbi.nlm.nih.gov/pubmed/16257489","type":"PUBMED","article":{"title":"The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells.","authors":["Liu X"," Wu JY"," Zhou F"," Sun XL"," Yao HH"," Yang Y"," Ding JH"," Hu G."],"journal":"Neuroscience letters","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16257489","id":"16257489","citationCount":16,"stringAuthors":"Liu X,  Wu JY,  Zhou F,  Sun XL,  Yao HH,  Yang Y,  Ding JH,  Hu G."}},{"resource":"25086357","link":"http://www.ncbi.nlm.nih.gov/pubmed/25086357","type":"PUBMED","article":{"title":"Downregulation of cystathionine β-synthase/hydrogen sulfide contributes to rotenone-induced microglia polarization toward M1 type.","authors":["Du C"," Jin M"," Hong Y"," Li Q"," Wang XH"," Xu JM"," Wang F"," Zhang Y"," Jia J"," Liu CF"," Hu LF."],"journal":"Biochemical and biophysical research communications","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25086357","id":"25086357","citationCount":8,"stringAuthors":"Du C,  Jin M,  Hong Y,  Li Q,  Wang XH,  Xu JM,  Wang F,  Zhang Y,  Jia J,  Liu CF,  Hu LF."}},{"resource":"24830863","link":"http://www.ncbi.nlm.nih.gov/pubmed/24830863","type":"PUBMED","article":{"title":"Rotenone, a mitochondrial respiratory complex I inhibitor, ameliorates lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice.","authors":["Ai Q"," Jing Y"," Jiang R"," Lin L"," Dai J"," Che Q"," Zhou D"," Jia M"," Wan J"," Zhang L."],"journal":"International immunopharmacology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24830863","id":"24830863","citationCount":8,"stringAuthors":"Ai Q,  Jing Y,  Jiang R,  Lin L,  Dai J,  Che Q,  Zhou D,  Jia M,  Wan J,  Zhang L."}},{"resource":"21807080","link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","type":"PUBMED","article":{"title":"An effective novel delivery strategy of rasagiline for Parkinson's disease.","authors":["Fernández M"," Negro S"," Slowing K"," Fernández-Carballido A"," Barcia E."],"journal":"International journal of pharmaceutics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","id":"21807080","citationCount":8,"stringAuthors":"Fernández M,  Negro S,  Slowing K,  Fernández-Carballido A,  Barcia E."}},{"resource":"23593274","link":"http://www.ncbi.nlm.nih.gov/pubmed/23593274","type":"PUBMED","article":{"title":"Resveratrol confers protection against rotenone-induced neurotoxicity by modulating myeloperoxidase levels in glial cells.","authors":["Chang CY"," Choi DK"," Lee DK"," Hong YJ"," Park EJ."],"journal":"PloS one","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23593274","id":"23593274","citationCount":8,"stringAuthors":"Chang CY,  Choi DK,  Lee DK,  Hong YJ,  Park EJ."}},{"resource":"15720824","link":"http://www.ncbi.nlm.nih.gov/pubmed/15720824","type":"PUBMED","article":{"title":"Rotenone, a mitochondrial electron transport inhibitor, ameliorates ischemia-reperfusion-induced intestinal mucosal damage in rats.","authors":["Ichikawa H"," Takagi T"," Uchiyama K"," Higashihara H"," Katada K"," Isozaki Y"," Naito Y"," Yoshida N"," Yoshikawa T."],"journal":"Redox report : communications in free radical research","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15720824","id":"15720824","citationCount":7,"stringAuthors":"Ichikawa H,  Takagi T,  Uchiyama K,  Higashihara H,  Katada K,  Isozaki Y,  Naito Y,  Yoshida N,  Yoshikawa T."}},{"resource":"23645222","link":"http://www.ncbi.nlm.nih.gov/pubmed/23645222","type":"PUBMED","article":{"title":"Rotenone could activate microglia through NFκB associated pathway.","authors":["Yuan YH"," Sun JD"," Wu MM"," Hu JF"," Peng SY"," Chen NH."],"journal":"Neurochemical research","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23645222","id":"23645222","citationCount":7,"stringAuthors":"Yuan YH,  Sun JD,  Wu MM,  Hu JF,  Peng SY,  Chen NH."}},{"resource":"25481089","link":"http://www.ncbi.nlm.nih.gov/pubmed/25481089","type":"PUBMED","article":{"title":"Neuroprotective effects of bee venom acupuncture therapy against rotenone-induced oxidative stress and apoptosis.","authors":["Khalil WK"," Assaf N"," ElShebiney SA"," Salem NA."],"journal":"Neurochemistry international","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25481089","id":"25481089","citationCount":5,"stringAuthors":"Khalil WK,  Assaf N,  ElShebiney SA,  Salem NA."}}],"name":"TNF","targetParticipants":[{"resource":"TNF","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=TNF","id":0,"type":"HGNC_SYMBOL"}]}]}]
\ No newline at end of file
+[{"references":[{"resource":"D012402","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://ctdbase.org/detail.go?type=chem&acc=D012402","id":0,"type":"TOXICOGENOMIC_CHEMICAL"},{"resource":"83-79-4","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://commonchemistry.org/ChemicalDetail.aspx?ref=83-79-4","id":0,"type":"CAS"}],"synonyms":[],"name":"Rotenone","description":"A botanical insecticide that is an inhibitor of mitochondrial electron transport.","id":{"id":0,"relationType":"BQ_BIOL_IS_DESCRIBED_BY","dataType":"TOXICOGENOMIC_CHEMICAL","resource":"D012402","annotator":null},"directEvidenceReferences":[],"directEvidence":"marker/mechanism","targets":[{"targetElements":[],"references":[{"resource":"23098804","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/23098804","id":0,"type":"PUBMED","article":{"title":"Rotenone-induced neurotoxicity in rat brain areas: a study on neuronal and neuronal supportive cells.","authors":["Swarnkar S"," Goswami P"," Kamat PK"," Patro IK"," Singh S"," Nath C."],"journal":"Neuroscience","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23098804","id":"23098804","citationCount":5,"stringAuthors":"Swarnkar S,  Goswami P,  Kamat PK,  Patro IK,  Singh S,  Nath C."}}],"name":"GFAP","targetParticipants":[{"resource":"GFAP","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GFAP","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"23186747","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":0,"type":"PUBMED","article":{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":5,"stringAuthors":"Yap YW,  Chen MJ,  Peng ZF,  Manikandan J,  Ng JM,  Llanos RM,  La Fontaine S,  Beart PM,  Cheung NS."}}],"name":"GSTM1","targetParticipants":[{"resource":"GSTM1","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GSTM1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"23189969","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/23189969","id":0,"type":"PUBMED","article":{"title":"Transient exposure to echinacoside is sufficient to activate Trk signaling and protect neuronal cells from rotenone.","authors":["Zhu M"," Lu C"," Li W."],"journal":"Journal of neurochemistry","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23189969","id":"23189969","citationCount":8,"stringAuthors":"Zhu M,  Lu C,  Li W."}}],"name":"NGF","targetParticipants":[{"resource":"NGF","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NGF","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"22847264","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/22847264","id":0,"type":"PUBMED","article":{"title":"Characterization of cellular protective effects of ATP13A2/PARK9 expression and alterations resulting from pathogenic mutants.","authors":["Covy JP"," Waxman EA"," Giasson BI."],"journal":"Journal of neuroscience research","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22847264","id":"22847264","citationCount":15,"stringAuthors":"Covy JP,  Waxman EA,  Giasson BI."}}],"name":"ATP13A2","targetParticipants":[{"resource":"ATP13A2","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ATP13A2","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"18619942","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/18619942","id":0,"type":"PUBMED","article":{"title":"Overexpression of Kir2.3 in PC12 cells resists rotenone-induced neurotoxicity associated with PKC signaling pathway.","authors":["Wang G"," Zeng J"," Shen CY"," Wang ZQ"," Chen SD."],"journal":"Biochemical and biophysical research communications","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18619942","id":"18619942","citationCount":3,"stringAuthors":"Wang G,  Zeng J,  Shen CY,  Wang ZQ,  Chen SD."}}],"name":"KCNJ4","targetParticipants":[{"resource":"KCNJ4","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=KCNJ4","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"21383081","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/21383081","id":0,"type":"PUBMED","article":{"title":"Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson's disease model.","authors":["Choi WS"," Palmiter RD"," Xia Z."],"journal":"The Journal of cell biology","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21383081","id":"21383081","citationCount":65,"stringAuthors":"Choi WS,  Palmiter RD,  Xia Z."}},{"resource":"26276080","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/26276080","id":0,"type":"PUBMED","article":{"title":"Pyrroloquinoline quinone-conferred neuroprotection in rotenone models of Parkinson's disease.","authors":["Qin J"," Wu M"," Yu S"," Gao X"," Zhang J"," Dong X"," Ji J"," Zhang Y"," Zhou L"," Zhang Q"," Ding F."],"journal":"Toxicology letters","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26276080","id":"26276080","citationCount":3,"stringAuthors":"Qin J,  Wu M,  Yu S,  Gao X,  Zhang J,  Dong X,  Ji J,  Zhang Y,  Zhou L,  Zhang Q,  Ding F."}},{"resource":"18579341","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/18579341","id":0,"type":"PUBMED","article":{"title":"Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism.","authors":["Sai Y"," Wu Q"," Le W"," Ye F"," Li Y"," Dong Z."],"journal":"Toxicology in vitro : an international journal published in association with BIBRA","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18579341","id":"18579341","citationCount":27,"stringAuthors":"Sai Y,  Wu Q,  Le W,  Ye F,  Li Y,  Dong Z."}},{"resource":"25496994","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/25496994","id":0,"type":"PUBMED","article":{"title":"JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death.","authors":["Choi WS"," Kim HW"," Xia Z."],"journal":"Toxicology","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25496994","id":"25496994","citationCount":2,"stringAuthors":"Choi WS,  Kim HW,  Xia Z."}}],"name":"SLC18A2","targetParticipants":[{"resource":"SLC18A2","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SLC18A2","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"18646205","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/18646205","id":0,"type":"PUBMED","article":{"title":"Pitx3-transfected astrocytes secrete brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor and protect dopamine neurons in mesencephalon cultures.","authors":["Yang D"," Peng C"," Li X"," Fan X"," Li L"," Ming M"," Chen S"," Le W."],"journal":"Journal of neuroscience research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18646205","id":"18646205","citationCount":13,"stringAuthors":"Yang D,  Peng C,  Li X,  Fan X,  Li L,  Ming M,  Chen S,  Le W."}},{"resource":"28389404","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/28389404","id":0,"type":"PUBMED","article":{"title":"Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis.","authors":["Anusha C"," Sumathi T"," Joseph LD."],"journal":"Chemico-biological interactions","year":2017,"link":"http://www.ncbi.nlm.nih.gov/pubmed/28389404","id":"28389404","citationCount":3,"stringAuthors":"Anusha C,  Sumathi T,  Joseph LD."}}],"name":"GDNF","targetParticipants":[{"resource":"GDNF","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GDNF","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"16930453","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/16930453","id":0,"type":"PUBMED","article":{"title":"Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.","authors":["Dickey CA"," Ash P"," Klosak N"," Lee WC"," Petrucelli L"," Hutton M"," Eckman CB."],"journal":"Molecular neurodegeneration","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16930453","id":"16930453","citationCount":17,"stringAuthors":"Dickey CA,  Ash P,  Klosak N,  Lee WC,  Petrucelli L,  Hutton M,  Eckman CB."}},{"resource":"16219024","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/16219024","id":0,"type":"PUBMED","article":{"title":"The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy.","authors":["Höglinger GU"," Lannuzel A"," Khondiker ME"," Michel PP"," Duyckaerts C"," Féger J"," Champy P"," Prigent A"," Medja F"," Lombes A"," Oertel WH"," Ruberg M"," Hirsch EC."],"journal":"Journal of neurochemistry","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16219024","id":"16219024","citationCount":76,"stringAuthors":"Höglinger GU,  Lannuzel A,  Khondiker ME,  Michel PP,  Duyckaerts C,  Féger J,  Champy P,  Prigent A,  Medja F,  Lombes A,  Oertel WH,  Ruberg M,  Hirsch EC."}}],"name":"MAPT","targetParticipants":[{"resource":"MAPT","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MAPT","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"22928487","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/22928487","id":0,"type":"PUBMED","article":{"title":"Mitochondrial ROS-K+ channel signaling pathway regulated secretion of human pulmonary artery endothelial cells.","authors":["Ouyang JS"," Li YP"," Li CY"," Cai C"," Chen CS"," Chen SX"," Chen YF"," Yang L"," Xie YP."],"journal":"Free radical research","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22928487","id":"22928487","citationCount":5,"stringAuthors":"Ouyang JS,  Li YP,  Li CY,  Cai C,  Chen CS,  Chen SX,  Chen YF,  Yang L,  Xie YP."}},{"resource":"11707688","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/11707688","id":0,"type":"PUBMED","article":{"title":"Endothelin-1 production is enhanced by rotenone, a mitochondrial complex I inhibitor, in cultured rat cardiomyocytes.","authors":["Yuhki KI"," Miyauchi T"," Kakinuma Y"," Murakoshi N"," Maeda S"," Goto K"," Yamaguchi I"," Suzuki T."],"journal":"Journal of cardiovascular pharmacology","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11707688","id":"11707688","citationCount":7,"stringAuthors":"Yuhki KI,  Miyauchi T,  Kakinuma Y,  Murakoshi N,  Maeda S,  Goto K,  Yamaguchi I,  Suzuki T."}},{"resource":"11078378","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/11078378","id":0,"type":"PUBMED","article":{"title":"Mitochondrial dysfunction increases expression of endothelin-1 and induces apoptosis through caspase-3 activation in rat cardiomyocytes in vitro.","authors":["Yuki K"," Miyauchi T"," Kakinuma Y"," Murakoshi N"," Suzuki T"," Hayashi J"," Goto K"," Yamaguchi I."],"journal":"Journal of cardiovascular pharmacology","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11078378","id":"11078378","citationCount":9,"stringAuthors":"Yuki K,  Miyauchi T,  Kakinuma Y,  Murakoshi N,  Suzuki T,  Hayashi J,  Goto K,  Yamaguchi I."}}],"name":"EDN1","targetParticipants":[{"resource":"EDN1","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=EDN1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"16565515","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/16565515","id":0,"type":"PUBMED","article":{"title":"Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease.","authors":["Jin J"," Hulette C"," Wang Y"," Zhang T"," Pan C"," Wadhwa R"," Zhang J."],"journal":"Molecular & cellular proteomics : MCP","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16565515","id":"16565515","citationCount":110,"stringAuthors":"Jin J,  Hulette C,  Wang Y,  Zhang T,  Pan C,  Wadhwa R,  Zhang J."}},{"resource":"23186747","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":0,"type":"PUBMED","article":{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":5,"stringAuthors":"Yap YW,  Chen MJ,  Peng ZF,  Manikandan J,  Ng JM,  Llanos RM,  La Fontaine S,  Beart PM,  Cheung NS."}}],"name":"HSPA9","targetParticipants":[{"resource":"HSPA9","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSPA9","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"16449798","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/16449798","id":0,"type":"PUBMED","article":{"title":"Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice.","authors":["Hsieh CC"," Papaconstantinou J."],"journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16449798","id":"16449798","citationCount":84,"stringAuthors":"Hsieh CC,  Papaconstantinou J."}}],"name":"MAP3K5","targetParticipants":[{"resource":"MAP3K5","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MAP3K5","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"23186747","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":0,"type":"PUBMED","article":{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":5,"stringAuthors":"Yap YW,  Chen MJ,  Peng ZF,  Manikandan J,  Ng JM,  Llanos RM,  La Fontaine S,  Beart PM,  Cheung NS."}}],"name":"GSTA4","targetParticipants":[{"resource":"GSTA4","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GSTA4","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"24764117","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/24764117","id":0,"type":"PUBMED","article":{"title":"RTP801 regulates maneb- and mancozeb-induced cytotoxicity via NF-κB.","authors":["Cheng SY"," Oh S"," Velasco M"," Ta C"," Montalvo J"," Calderone A."],"journal":"Journal of biochemical and molecular toxicology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24764117","id":"24764117","citationCount":1,"stringAuthors":"Cheng SY,  Oh S,  Velasco M,  Ta C,  Montalvo J,  Calderone A."}}],"name":"DDIT4","targetParticipants":[{"resource":"DDIT4","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DDIT4","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"19019832","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/19019832","id":0,"type":"PUBMED","article":{"title":"Reactive oxygen species regulate ceruloplasmin by a novel mRNA decay mechanism involving its 3'-untranslated region: implications in neurodegenerative diseases.","authors":["Tapryal N"," Mukhopadhyay C"," Das D"," Fox PL"," Mukhopadhyay CK."],"journal":"The Journal of Biological Chemistry","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19019832","id":"19019832","citationCount":18,"stringAuthors":"Tapryal N,  Mukhopadhyay C,  Das D,  Fox PL,  Mukhopadhyay CK."}},{"resource":"18804145","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/18804145","id":0,"type":"PUBMED","article":{"title":"Increased vulnerability to rotenone-induced neurotoxicity in ceruloplasmin-deficient mice.","authors":["Kaneko K"," Hineno A"," Yoshida K"," Ikeda S."],"journal":"Neuroscience letters","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18804145","id":"18804145","citationCount":11,"stringAuthors":"Kaneko K,  Hineno A,  Yoshida K,  Ikeda S."}}],"name":"CP","targetParticipants":[{"resource":"CP","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=CP","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"17079513","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","id":0,"type":"PUBMED","article":{"title":"Microtubule: a common target for parkin and Parkinson's disease toxins.","authors":["Feng J."],"journal":"The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","id":"17079513","citationCount":34,"stringAuthors":"Feng J."}},{"resource":"17657281","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":0,"type":"PUBMED","article":{"title":"The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.","authors":["Panee J"," Liu W"," Nakamura K"," Berry MJ."],"journal":"International journal of biological sciences","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":"17657281","citationCount":13,"stringAuthors":"Panee J,  Liu W,  Nakamura K,  Berry MJ."}},{"resource":"17070561","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","id":0,"type":"PUBMED","article":{"title":"Standardized Hypericum perforatum reduces oxidative stress and increases gene expression of antioxidant enzymes on rotenone-exposed rats.","authors":["Sánchez-Reus MI"," Gómez del Rio MA"," Iglesias I"," Elorza M"," Slowing K"," Benedí J."],"journal":"Neuropharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","id":"17070561","citationCount":21,"stringAuthors":"Sánchez-Reus MI,  Gómez del Rio MA,  Iglesias I,  Elorza M,  Slowing K,  Benedí J."}},{"resource":"15904944","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/15904944","id":0,"type":"PUBMED","article":{"title":"Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine.","authors":["Molina-Jiménez MF"," Sánchez-Reus MI"," Cascales M"," Andrés D"," Benedí J."],"journal":"Toxicology and applied pharmacology","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15904944","id":"15904944","citationCount":14,"stringAuthors":"Molina-Jiménez MF,  Sánchez-Reus MI,  Cascales M,  Andrés D,  Benedí J."}}],"name":"GPX1","targetParticipants":[{"resource":"GPX1","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GPX1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"28245986","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/28245986","id":0,"type":"PUBMED","article":{"title":"DJ-1 regulating PI3K-Nrf2 signaling plays a significant role in bibenzyl compound 20C-mediated neuroprotection against rotenone-induced oxidative insult.","authors":["Zhang XL"," Yuan YH"," Shao QH"," Wang ZZ"," Zhu CG"," Shi JG"," Ma KL"," Yan X"," Chen NH."],"journal":"Toxicology letters","year":2017,"link":"http://www.ncbi.nlm.nih.gov/pubmed/28245986","id":"28245986","citationCount":0,"stringAuthors":"Zhang XL,  Yuan YH,  Shao QH,  Wang ZZ,  Zhu CG,  Shi JG,  Ma KL,  Yan X,  Chen NH."}},{"resource":"26739068","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/26739068","id":0,"type":"PUBMED","article":{"title":"L10P mutation in DJ-1 gene induced oxidative stress and mitochondrial disfunction.","authors":["Guo J"," He D"," Wang L"," Kang J"," Li N"," Yan X"," Tang B."],"journal":"Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26739068","id":"26739068","citationCount":0,"stringAuthors":"Guo J,  He D,  Wang L,  Kang J,  Li N,  Yan X,  Tang B."}},{"resource":"16439141","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/16439141","id":0,"type":"PUBMED","article":{"title":"Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system.","authors":["Betarbet R"," Canet-Aviles RM"," Sherer TB"," Mastroberardino PG"," McLendon C"," Kim JH"," Lund S"," Na HM"," Taylor G"," Bence NF"," Kopito R"," Seo BB"," Yagi T"," Yagi A"," Klinefelter G"," Cookson MR"," Greenamyre JT."],"journal":"Neurobiology of disease","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16439141","id":"16439141","citationCount":131,"stringAuthors":"Betarbet R,  Canet-Aviles RM,  Sherer TB,  Mastroberardino PG,  McLendon C,  Kim JH,  Lund S,  Na HM,  Taylor G,  Bence NF,  Kopito R,  Seo BB,  Yagi T,  Yagi A,  Klinefelter G,  Cookson MR,  Greenamyre JT."}},{"resource":"28348719","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/28348719","id":0,"type":"PUBMED","article":{"title":"BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage.","authors":["Qin LX"," Tan JQ"," Zhang HN"," Rizwana K"," Lu JH"," Tang JG"," Jiang B"," Shen XM"," Guo JF"," Tang BS"," Tan LM"," Wang CY."],"journal":"Oxidative Medicine and Cellular Longevity","year":2017,"link":"http://www.ncbi.nlm.nih.gov/pubmed/28348719","id":"28348719","citationCount":1,"stringAuthors":"Qin LX,  Tan JQ,  Zhang HN,  Rizwana K,  Lu JH,  Tang JG,  Jiang B,  Shen XM,  Guo JF,  Tang BS,  Tan LM,  Wang CY."}},{"resource":"18377993","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/18377993","id":0,"type":"PUBMED","article":{"title":"Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection.","authors":["Lev N"," Ickowicz D"," Melamed E"," Offen D."],"journal":"Neurotoxicology","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18377993","id":"18377993","citationCount":59,"stringAuthors":"Lev N,  Ickowicz D,  Melamed E,  Offen D."}},{"resource":"21219333","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/21219333","id":0,"type":"PUBMED","article":{"title":"DJ-1 deficiency in astrocytes selectively enhances mitochondrial Complex I inhibitor-induced neurotoxicity.","authors":["Mullett SJ"," Hinkle DA."],"journal":"Journal of neurochemistry","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21219333","id":"21219333","citationCount":30,"stringAuthors":"Mullett SJ,  Hinkle DA."}},{"resource":"18930142","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/18930142","id":0,"type":"PUBMED","article":{"title":"DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone.","authors":["Mullett SJ"," Hinkle DA."],"journal":"Neurobiology of disease","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18930142","id":"18930142","citationCount":43,"stringAuthors":"Mullett SJ,  Hinkle DA."}},{"resource":"21907265","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/21907265","id":0,"type":"PUBMED","article":{"title":"DJ-1 knock-down impairs astrocyte mitochondrial function.","authors":["Larsen NJ"," Ambrosi G"," Mullett SJ"," Berman SB"," Hinkle DA."],"journal":"Neuroscience","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21907265","id":"21907265","citationCount":31,"stringAuthors":"Larsen NJ,  Ambrosi G,  Mullett SJ,  Berman SB,  Hinkle DA."}},{"resource":"20940149","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","id":0,"type":"PUBMED","article":{"title":"DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.","authors":["Thomas KJ"," McCoy MK"," Blackinton J"," Beilina A"," van der Brug M"," Sandebring A"," Miller D"," Maric D"," Cedazo-Minguez A"," Cookson MR."],"journal":"Human molecular genetics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","id":"20940149","citationCount":148,"stringAuthors":"Thomas KJ,  McCoy MK,  Blackinton J,  Beilina A,  van der Brug M,  Sandebring A,  Miller D,  Maric D,  Cedazo-Minguez A,  Cookson MR."}},{"resource":"18331584","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/18331584","id":0,"type":"PUBMED","article":{"title":"Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease.","authors":["Liu F"," Nguyen JL"," Hulleman JD"," Li L"," Rochet JC."],"journal":"Journal of neurochemistry","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18331584","id":"18331584","citationCount":48,"stringAuthors":"Liu F,  Nguyen JL,  Hulleman JD,  Li L,  Rochet JC."}},{"resource":"19063952","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/19063952","id":0,"type":"PUBMED","article":{"title":"Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes.","authors":["Ashley AK"," Hanneman WH"," Katoh T"," Moreno JA"," Pollack A"," Tjalkens RB"," Legare ME."],"journal":"Toxicology letters","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19063952","id":"19063952","citationCount":15,"stringAuthors":"Ashley AK,  Hanneman WH,  Katoh T,  Moreno JA,  Pollack A,  Tjalkens RB,  Legare ME."}},{"resource":"16624565","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/16624565","id":0,"type":"PUBMED","article":{"title":"Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase.","authors":["Pisani A"," Martella G"," Tscherter A"," Costa C"," Mercuri NB"," Bernardi G"," Shen J"," Calabresi P."],"journal":"Neurobiology of disease","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16624565","id":"16624565","citationCount":23,"stringAuthors":"Pisani A,  Martella G,  Tscherter A,  Costa C,  Mercuri NB,  Bernardi G,  Shen J,  Calabresi P."}},{"resource":"22898350","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/22898350","id":0,"type":"PUBMED","article":{"title":"DJ-1 protects dopaminergic neurons against rotenone-induced apoptosis by enhancing ERK-dependent mitophagy.","authors":["Gao H"," Yang W"," Qi Z"," Lu L"," Duan C"," Zhao C"," Yang H."],"journal":"Journal of molecular biology","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22898350","id":"22898350","citationCount":21,"stringAuthors":"Gao H,  Yang W,  Qi Z,  Lu L,  Duan C,  Zhao C,  Yang H."}},{"resource":"26806867","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/26806867","id":0,"type":"PUBMED","article":{"title":"Expression changes of genes associated with apoptosis and survival processes in Parkinson's disease.","authors":["Yalçınkaya N"," Haytural H"," Bilgiç B"," Özdemir Ö"," HanaÄŸası H"," Küçükali CÄ°"," Özbek Z"," Akcan U"," Ä°drisoÄŸlu HA"," Gürvit H"," Tüzün E."],"journal":"Neuroscience letters","year":2016,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26806867","id":"26806867","citationCount":2,"stringAuthors":"Yalçınkaya N,  Haytural H,  Bilgiç B,  Özdemir Ö,  HanaÄŸası H,  Küçükali CÄ°,  Özbek Z,  Akcan U,  Ä°drisoÄŸlu HA,  Gürvit H,  Tüzün E."}},{"resource":"17459145","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/17459145","id":0,"type":"PUBMED","article":{"title":"Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.","authors":["Inden M"," Kitamura Y"," Takeuchi H"," Yanagida T"," Takata K"," Kobayashi Y"," Taniguchi T"," Yoshimoto K"," Kaneko M"," Okuma Y"," Taira T"," Ariga H"," Shimohama S."],"journal":"Journal of neurochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17459145","id":"17459145","citationCount":68,"stringAuthors":"Inden M,  Kitamura Y,  Takeuchi H,  Yanagida T,  Takata K,  Kobayashi Y,  Taniguchi T,  Yoshimoto K,  Kaneko M,  Okuma Y,  Taira T,  Ariga H,  Shimohama S."}}],"name":"PARK7","targetParticipants":[{"resource":"PARK7","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PARK7","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"28903492","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/28903492","id":0,"type":"PUBMED","article":{"title":"Editor's Highlight: Nlrp3 Is Required for Inflammatory Changes and Nigral Cell Loss Resulting From Chronic Intragastric Rotenone Exposure in Mice.","authors":["Martinez EM"," Young AL"," Patankar YR"," Berwin BL"," Wang L"," von Herrmann KM"," Weier JM"," Havrda MC."],"journal":"Toxicological sciences : an official journal of the Society of Toxicology","year":2017,"link":"http://www.ncbi.nlm.nih.gov/pubmed/28903492","id":"28903492","citationCount":0,"stringAuthors":"Martinez EM,  Young AL,  Patankar YR,  Berwin BL,  Wang L,  von Herrmann KM,  Weier JM,  Havrda MC."}},{"resource":"24830863","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/24830863","id":0,"type":"PUBMED","article":{"title":"Rotenone, a mitochondrial respiratory complex I inhibitor, ameliorates lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice.","authors":["Ai Q"," Jing Y"," Jiang R"," Lin L"," Dai J"," Che Q"," Zhou D"," Jia M"," Wan J"," Zhang L."],"journal":"International immunopharmacology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24830863","id":"24830863","citationCount":8,"stringAuthors":"Ai Q,  Jing Y,  Jiang R,  Lin L,  Dai J,  Che Q,  Zhou D,  Jia M,  Wan J,  Zhang L."}},{"resource":"22745725","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/22745725","id":0,"type":"PUBMED","article":{"title":"Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat.","authors":["Paulus P"," Ockelmann P"," Tacke S"," Karnowski N"," Ellinghaus P"," Scheller B"," Holfeld J"," Urbschat A"," Zacharowski K."],"journal":"PloS one","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22745725","id":"22745725","citationCount":10,"stringAuthors":"Paulus P,  Ockelmann P,  Tacke S,  Karnowski N,  Ellinghaus P,  Scheller B,  Holfeld J,  Urbschat A,  Zacharowski K."}},{"resource":"19635391","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/19635391","id":0,"type":"PUBMED","article":{"title":"Environmental toxicants inhibit neuronal Jak tyrosine kinase by mitochondrial disruption.","authors":["Monroe RK"," Halvorsen SW."],"journal":"Neurotoxicology","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19635391","id":"19635391","citationCount":16,"stringAuthors":"Monroe RK,  Halvorsen SW."}},{"resource":"23867654","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/23867654","id":0,"type":"PUBMED","article":{"title":"Reactive oxygen species regulate context-dependent inhibition of NFAT5 target genes.","authors":["Kim NH"," Hong BK"," Choi SY"," Moo Kwon H"," Cho CS"," Yi EC"," Kim WU."],"journal":"Experimental & molecular medicine","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23867654","id":"23867654","citationCount":5,"stringAuthors":"Kim NH,  Hong BK,  Choi SY,  Moo Kwon H,  Cho CS,  Yi EC,  Kim WU."}},{"resource":"16837928","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/16837928","id":0,"type":"PUBMED","article":{"title":"Albumin-bound fatty acids induce mitochondrial oxidant stress and impair antioxidant responses in proximal tubular cells.","authors":["Ishola DA"," Post JA"," van Timmeren MM"," Bakker SJ"," Goldschmeding R"," Koomans HA"," Braam B"," Joles JA."],"journal":"Kidney international","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16837928","id":"16837928","citationCount":26,"stringAuthors":"Ishola DA,  Post JA,  van Timmeren MM,  Bakker SJ,  Goldschmeding R,  Koomans HA,  Braam B,  Joles JA."}},{"resource":"28389404","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/28389404","id":0,"type":"PUBMED","article":{"title":"Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis.","authors":["Anusha C"," Sumathi T"," Joseph LD."],"journal":"Chemico-biological interactions","year":2017,"link":"http://www.ncbi.nlm.nih.gov/pubmed/28389404","id":"28389404","citationCount":3,"stringAuthors":"Anusha C,  Sumathi T,  Joseph LD."}},{"resource":"15135310","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/15135310","id":0,"type":"PUBMED","article":{"title":"Inverse gene expression patterns for macrophage activating hepatotoxicants and peroxisome proliferators in rat liver.","authors":["McMillian M"," Nie AY"," Parker JB"," Leone A"," Kemmerer M"," Bryant S"," Herlich J"," Yieh L"," Bittner A"," Liu X"," Wan J"," Johnson MD."],"journal":"Biochemical pharmacology","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15135310","id":"15135310","citationCount":27,"stringAuthors":"McMillian M,  Nie AY,  Parker JB,  Leone A,  Kemmerer M,  Bryant S,  Herlich J,  Yieh L,  Bittner A,  Liu X,  Wan J,  Johnson MD."}},{"resource":"11950692","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/11950692","id":0,"type":"PUBMED","article":{"title":"Role of mitochondrial oxidant generation in endothelial cell responses to hypoxia.","authors":["Pearlstein DP"," Ali MH"," Mungai PT"," Hynes KL"," Gewertz BL"," Schumacker PT."],"journal":"Arteriosclerosis, thrombosis, and vascular biology","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11950692","id":"11950692","citationCount":54,"stringAuthors":"Pearlstein DP,  Ali MH,  Mungai PT,  Hynes KL,  Gewertz BL,  Schumacker PT."}}],"name":"IL6","targetParticipants":[{"resource":"IL6","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IL6","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"20940149","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","id":0,"type":"PUBMED","article":{"title":"DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.","authors":["Thomas KJ"," McCoy MK"," Blackinton J"," Beilina A"," van der Brug M"," Sandebring A"," Miller D"," Maric D"," Cedazo-Minguez A"," Cookson MR."],"journal":"Human molecular genetics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","id":"20940149","citationCount":148,"stringAuthors":"Thomas KJ,  McCoy MK,  Blackinton J,  Beilina A,  van der Brug M,  Sandebring A,  Miller D,  Maric D,  Cedazo-Minguez A,  Cookson MR."}},{"resource":"21421046","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/21421046","id":0,"type":"PUBMED","article":{"title":"PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons.","authors":["Wang HL"," Chou AH"," Wu AS"," Chen SY"," Weng YH"," Kao YC"," Yeh TH"," Chu PJ"," Lu CS."],"journal":"Biochimica et biophysica acta","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21421046","id":"21421046","citationCount":40,"stringAuthors":"Wang HL,  Chou AH,  Wu AS,  Chen SY,  Weng YH,  Kao YC,  Yeh TH,  Chu PJ,  Lu CS."}},{"resource":"19492085","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/19492085","id":0,"type":"PUBMED","article":{"title":"Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.","authors":["Sandebring A"," Thomas KJ"," Beilina A"," van der Brug M"," Cleland MM"," Ahmad R"," Miller DW"," Zambrano I"," Cowburn RF"," Behbahani H"," Cedazo-Mínguez A"," Cookson MR."],"journal":"PloS one","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19492085","id":"19492085","citationCount":93,"stringAuthors":"Sandebring A,  Thomas KJ,  Beilina A,  van der Brug M,  Cleland MM,  Ahmad R,  Miller DW,  Zambrano I,  Cowburn RF,  Behbahani H,  Cedazo-Mínguez A,  Cookson MR."}},{"resource":"20464527","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/20464527","id":0,"type":"PUBMED","article":{"title":"α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment.","authors":["George S"," Mok SS"," Nurjono M"," Ayton S"," Finkelstein DI"," Masters CL"," Li QX"," Culvenor JG."],"journal":"Journal of molecular neuroscience : MN","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20464527","id":"20464527","citationCount":14,"stringAuthors":"George S,  Mok SS,  Nurjono M,  Ayton S,  Finkelstein DI,  Masters CL,  Li QX,  Culvenor JG."}},{"resource":"16226715","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/16226715","id":0,"type":"PUBMED","article":{"title":"Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y.","authors":["Deng H"," Jankovic J"," Guo Y"," Xie W"," Le W."],"journal":"Biochemical and biophysical research communications","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16226715","id":"16226715","citationCount":72,"stringAuthors":"Deng H,  Jankovic J,  Guo Y,  Xie W,  Le W."}}],"name":"PINK1","targetParticipants":[{"resource":"PINK1","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PINK1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"17079513","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","id":0,"type":"PUBMED","article":{"title":"Microtubule: a common target for parkin and Parkinson's disease toxins.","authors":["Feng J."],"journal":"The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","id":"17079513","citationCount":34,"stringAuthors":"Feng J."}},{"resource":"17657281","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":0,"type":"PUBMED","article":{"title":"The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.","authors":["Panee J"," Liu W"," Nakamura K"," Berry MJ."],"journal":"International journal of biological sciences","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":"17657281","citationCount":13,"stringAuthors":"Panee J,  Liu W,  Nakamura K,  Berry MJ."}},{"resource":"24374061","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/24374061","id":0,"type":"PUBMED","article":{"title":"PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1.","authors":["Corona JC"," de Souza SC"," Duchen MR."],"journal":"Experimental neurology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24374061","id":"24374061","citationCount":12,"stringAuthors":"Corona JC,  de Souza SC,  Duchen MR."}},{"resource":"17070561","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","id":0,"type":"PUBMED","article":{"title":"Standardized Hypericum perforatum reduces oxidative stress and increases gene expression of antioxidant enzymes on rotenone-exposed rats.","authors":["Sánchez-Reus MI"," Gómez del Rio MA"," Iglesias I"," Elorza M"," Slowing K"," Benedí J."],"journal":"Neuropharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","id":"17070561","citationCount":21,"stringAuthors":"Sánchez-Reus MI,  Gómez del Rio MA,  Iglesias I,  Elorza M,  Slowing K,  Benedí J."}},{"resource":"22447502","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/22447502","id":0,"type":"PUBMED","article":{"title":"Molecular responses differ between sensitive silver carp and tolerant bighead carp and bigmouth buffalo exposed to rotenone.","authors":["Amberg JJ"," Schreier TM"," Gaikowski MP."],"journal":"Fish physiology and biochemistry","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22447502","id":"22447502","citationCount":3,"stringAuthors":"Amberg JJ,  Schreier TM,  Gaikowski MP."}},{"resource":"23639798","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/23639798","id":0,"type":"PUBMED","article":{"title":"Valeriana officinalis attenuates the rotenone-induced toxicity in Drosophila melanogaster.","authors":["Sudati JH"," Vieira FA"," Pavin SS"," Dias GR"," Seeger RL"," Golombieski R"," Athayde ML"," Soares FA"," Rocha JB"," Barbosa NV."],"journal":"Neurotoxicology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23639798","id":"23639798","citationCount":17,"stringAuthors":"Sudati JH,  Vieira FA,  Pavin SS,  Dias GR,  Seeger RL,  Golombieski R,  Athayde ML,  Soares FA,  Rocha JB,  Barbosa NV."}},{"resource":"21807080","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","id":0,"type":"PUBMED","article":{"title":"An effective novel delivery strategy of rasagiline for Parkinson's disease.","authors":["Fernández M"," Negro S"," Slowing K"," Fernández-Carballido A"," Barcia E."],"journal":"International journal of pharmaceutics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","id":"21807080","citationCount":8,"stringAuthors":"Fernández M,  Negro S,  Slowing K,  Fernández-Carballido A,  Barcia E."}}],"name":"SOD1","targetParticipants":[{"resource":"SOD1","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SOD1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"23098804","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/23098804","id":0,"type":"PUBMED","article":{"title":"Rotenone-induced neurotoxicity in rat brain areas: a study on neuronal and neuronal supportive cells.","authors":["Swarnkar S"," Goswami P"," Kamat PK"," Patro IK"," Singh S"," Nath C."],"journal":"Neuroscience","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23098804","id":"23098804","citationCount":5,"stringAuthors":"Swarnkar S,  Goswami P,  Kamat PK,  Patro IK,  Singh S,  Nath C."}}],"name":"AIF1","targetParticipants":[{"resource":"AIF1","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AIF1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"27535828","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/27535828","id":0,"type":"PUBMED","article":{"title":"Curcumin Monoglucoside Shows Improved Bioavailability and Mitigates Rotenone Induced Neurotoxicity in Cell and Drosophila Models of Parkinson's Disease.","authors":["Pandareesh MD"," Shrivash MK"," Naveen Kumar HN"," Misra K"," Srinivas Bharath MM."],"journal":"Neurochemical research","year":2016,"link":"http://www.ncbi.nlm.nih.gov/pubmed/27535828","id":"27535828","citationCount":1,"stringAuthors":"Pandareesh MD,  Shrivash MK,  Naveen Kumar HN,  Misra K,  Srinivas Bharath MM."}},{"resource":"28145852","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/28145852","id":0,"type":"PUBMED","article":{"title":"Safranal prevents rotenone-induced oxidative stress and apoptosis in an in vitro model of Parkinson's disease through regulating Keap1/Nrf2 signaling pathway.","authors":["Pan PK"," Qiao LY"," Wen XN."],"journal":"Cellular and molecular biology (Noisy-le-Grand, France)","year":2016,"link":"http://www.ncbi.nlm.nih.gov/pubmed/28145852","id":"28145852","citationCount":0,"stringAuthors":"Pan PK,  Qiao LY,  Wen XN."}},{"resource":"24374061","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/24374061","id":0,"type":"PUBMED","article":{"title":"PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1.","authors":["Corona JC"," de Souza SC"," Duchen MR."],"journal":"Experimental neurology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24374061","id":"24374061","citationCount":12,"stringAuthors":"Corona JC,  de Souza SC,  Duchen MR."}},{"resource":"27180985","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/27180985","id":0,"type":"PUBMED","article":{"title":"20C, a bibenzyl compound isolated from Gastrodia elata, protects PC12 cells against rotenone-induced apoptosis via activation of the Nrf2/ARE/HO-1 signaling pathway.","authors":["Huang JY"," Yuan YH"," Yan JQ"," Wang YN"," Chu SF"," Zhu CG"," Guo QL"," Shi JG"," Chen NH."],"journal":"Acta pharmacologica Sinica","year":2016,"link":"http://www.ncbi.nlm.nih.gov/pubmed/27180985","id":"27180985","citationCount":2,"stringAuthors":"Huang JY,  Yuan YH,  Yan JQ,  Wang YN,  Chu SF,  Zhu CG,  Guo QL,  Shi JG,  Chen NH."}},{"resource":"23186747","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":0,"type":"PUBMED","article":{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":5,"stringAuthors":"Yap YW,  Chen MJ,  Peng ZF,  Manikandan J,  Ng JM,  Llanos RM,  La Fontaine S,  Beart PM,  Cheung NS."}}],"name":"NQO1","targetParticipants":[{"resource":"NQO1","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NQO1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"17079513","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","id":0,"type":"PUBMED","article":{"title":"Microtubule: a common target for parkin and Parkinson's disease toxins.","authors":["Feng J."],"journal":"The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","id":"17079513","citationCount":34,"stringAuthors":"Feng J."}},{"resource":"10463952","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/10463952","id":0,"type":"PUBMED","article":{"title":"Overexpression of manganese superoxide dismutase protects against mitochondrial-initiated poly(ADP-ribose) polymerase-mediated cell death.","authors":["Kiningham KK"," Oberley TD"," Lin S"," Mattingly CA"," St Clair DK."],"journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10463952","id":"10463952","citationCount":48,"stringAuthors":"Kiningham KK,  Oberley TD,  Lin S,  Mattingly CA,  St Clair DK."}},{"resource":"17070561","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","id":0,"type":"PUBMED","article":{"title":"Standardized Hypericum perforatum reduces oxidative stress and increases gene expression of antioxidant enzymes on rotenone-exposed rats.","authors":["Sánchez-Reus MI"," Gómez del Rio MA"," Iglesias I"," Elorza M"," Slowing K"," Benedí J."],"journal":"Neuropharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","id":"17070561","citationCount":21,"stringAuthors":"Sánchez-Reus MI,  Gómez del Rio MA,  Iglesias I,  Elorza M,  Slowing K,  Benedí J."}},{"resource":"8989910","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/8989910","id":0,"type":"PUBMED","article":{"title":"Increased manganese superoxide dismutase activity, protein, and mRNA levels and concurrent induction of tumor necrosis factor alpha in radiation-initiated Syrian hamster cells.","authors":["Otero G"," Avila MA"," Emfietzoglou D"," Clerch LB"," Massaro D"," Notario V."],"journal":"Molecular carcinogenesis","year":1996,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8989910","id":"8989910","citationCount":7,"stringAuthors":"Otero G,  Avila MA,  Emfietzoglou D,  Clerch LB,  Massaro D,  Notario V."}},{"resource":"15904944","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/15904944","id":0,"type":"PUBMED","article":{"title":"Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine.","authors":["Molina-Jiménez MF"," Sánchez-Reus MI"," Cascales M"," Andrés D"," Benedí J."],"journal":"Toxicology and applied pharmacology","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15904944","id":"15904944","citationCount":14,"stringAuthors":"Molina-Jiménez MF,  Sánchez-Reus MI,  Cascales M,  Andrés D,  Benedí J."}},{"resource":"22447502","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/22447502","id":0,"type":"PUBMED","article":{"title":"Molecular responses differ between sensitive silver carp and tolerant bighead carp and bigmouth buffalo exposed to rotenone.","authors":["Amberg JJ"," Schreier TM"," Gaikowski MP."],"journal":"Fish physiology and biochemistry","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22447502","id":"22447502","citationCount":3,"stringAuthors":"Amberg JJ,  Schreier TM,  Gaikowski MP."}},{"resource":"21807080","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","id":0,"type":"PUBMED","article":{"title":"An effective novel delivery strategy of rasagiline for Parkinson's disease.","authors":["Fernández M"," Negro S"," Slowing K"," Fernández-Carballido A"," Barcia E."],"journal":"International journal of pharmaceutics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","id":"21807080","citationCount":8,"stringAuthors":"Fernández M,  Negro S,  Slowing K,  Fernández-Carballido A,  Barcia E."}},{"resource":"19818760","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/19818760","id":0,"type":"PUBMED","article":{"title":"Enhanced metallothionein gene expression induced by mitochondrial oxidative stress is reduced in phospholipid hydroperoxide glutathione peroxidase-overexpressed cells.","authors":["Kadota Y"," Suzuki S"," Ideta S"," Fukinbara Y"," Kawakami T"," Imai H"," Nakagawa Y"," Sato M."],"journal":"European journal of pharmacology","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19818760","id":"19818760","citationCount":7,"stringAuthors":"Kadota Y,  Suzuki S,  Ideta S,  Fukinbara Y,  Kawakami T,  Imai H,  Nakagawa Y,  Sato M."}},{"resource":"17657281","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":0,"type":"PUBMED","article":{"title":"The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.","authors":["Panee J"," Liu W"," Nakamura K"," Berry MJ."],"journal":"International journal of biological sciences","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":"17657281","citationCount":13,"stringAuthors":"Panee J,  Liu W,  Nakamura K,  Berry MJ."}},{"resource":"16179351","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/16179351","id":0,"type":"PUBMED","article":{"title":"Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress.","authors":["Hu Y"," Rosen DG"," Zhou Y"," Feng L"," Yang G"," Liu J"," Huang P."],"journal":"The Journal of biological chemistry","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16179351","id":"16179351","citationCount":103,"stringAuthors":"Hu Y,  Rosen DG,  Zhou Y,  Feng L,  Yang G,  Liu J,  Huang P."}},{"resource":"25843018","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/25843018","id":0,"type":"PUBMED","article":{"title":"Pyrroloquinoline quinone (PQQ) producing Escherichia coli Nissle 1917 (EcN) alleviates age associated oxidative stress and hyperlipidemia, and improves mitochondrial function in ageing rats.","authors":["Singh AK"," Pandey SK"," Saha G"," Gattupalli NK."],"journal":"Experimental gerontology","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25843018","id":"25843018","citationCount":2,"stringAuthors":"Singh AK,  Pandey SK,  Saha G,  Gattupalli NK."}},{"resource":"18032788","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/18032788","id":0,"type":"PUBMED","article":{"title":"Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species.","authors":["Chen Y"," McMillan-Ward E"," Kong J"," Israels SJ"," Gibson SB."],"journal":"Journal of cell science","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18032788","id":"18032788","citationCount":167,"stringAuthors":"Chen Y,  McMillan-Ward E,  Kong J,  Israels SJ,  Gibson SB."}},{"resource":"24036476","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/24036476","id":0,"type":"PUBMED","article":{"title":"Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells.","authors":["Chu CT"," Ji J"," Dagda RK"," Jiang JF"," Tyurina YY"," Kapralov AA"," Tyurin VA"," Yanamala N"," Shrivastava IH"," Mohammadyani D"," Wang KZQ"," Zhu J"," Klein-Seetharaman J"," Balasubramanian K"," Amoscato AA"," Borisenko G"," Huang Z"," Gusdon AM"," Cheikhi A"," Steer EK"," Wang R"," Baty C"," Watkins S"," Bahar I"," Bayir H"," Kagan VE."],"journal":"Nature cell biology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24036476","id":"24036476","citationCount":147,"stringAuthors":"Chu CT,  Ji J,  Dagda RK,  Jiang JF,  Tyurina YY,  Kapralov AA,  Tyurin VA,  Yanamala N,  Shrivastava IH,  Mohammadyani D,  Wang KZQ,  Zhu J,  Klein-Seetharaman J,  Balasubramanian K,  Amoscato AA,  Borisenko G,  Huang Z,  Gusdon AM,  Cheikhi A,  Steer EK,  Wang R,  Baty C,  Watkins S,  Bahar I,  Bayir H,  Kagan VE."}}],"name":"SOD2","targetParticipants":[{"resource":"SOD2","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SOD2","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"27900601","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/27900601","id":0,"type":"PUBMED","article":{"title":"RNA-Seq Expression Analysis of Enteric Neuron Cells with Rotenone Treatment and Prediction of Regulated Pathways.","authors":["Guan Q"," Wang X"," Jiang Y"," Zhao L"," Nie Z"," Jin L."],"journal":"Neurochemical research","year":2017,"link":"http://www.ncbi.nlm.nih.gov/pubmed/27900601","id":"27900601","citationCount":0,"stringAuthors":"Guan Q,  Wang X,  Jiang Y,  Zhao L,  Nie Z,  Jin L."}}],"name":"IGF2","targetParticipants":[{"resource":"IGF2","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IGF2","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"18206288","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/18206288","id":0,"type":"PUBMED","article":{"title":"The role of dopamine transporter in selective toxicity of manganese and rotenone.","authors":["Hirata Y"," Suzuno H"," Tsuruta T"," Oh-hashi K"," Kiuchi K."],"journal":"Toxicology","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18206288","id":"18206288","citationCount":4,"stringAuthors":"Hirata Y,  Suzuno H,  Tsuruta T,  Oh-hashi K,  Kiuchi K."}},{"resource":"18579341","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/18579341","id":0,"type":"PUBMED","article":{"title":"Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism.","authors":["Sai Y"," Wu Q"," Le W"," Ye F"," Li Y"," Dong Z."],"journal":"Toxicology in vitro : an international journal published in association with BIBRA","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18579341","id":"18579341","citationCount":27,"stringAuthors":"Sai Y,  Wu Q,  Le W,  Ye F,  Li Y,  Dong Z."}},{"resource":"18289173","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","id":0,"type":"PUBMED","article":{"title":"Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats.","authors":["Lin CH"," Huang JY"," Ching CH"," Chuang JI."],"journal":"Journal of pineal research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","id":"18289173","citationCount":32,"stringAuthors":"Lin CH,  Huang JY,  Ching CH,  Chuang JI."}},{"resource":"23567316","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/23567316","id":0,"type":"PUBMED","article":{"title":"Neonatal exposure to lipopolysaccharide enhances accumulation of α-synuclein aggregation and dopamine transporter protein expression in the substantia nigra in responses to rotenone challenge in later life.","authors":["Tien LT"," Kaizaki A"," Pang Y"," Cai Z"," Bhatt AJ"," Fan LW."],"journal":"Toxicology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23567316","id":"23567316","citationCount":6,"stringAuthors":"Tien LT,  Kaizaki A,  Pang Y,  Cai Z,  Bhatt AJ,  Fan LW."}}],"name":"SLC6A3","targetParticipants":[{"resource":"SLC6A3","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SLC6A3","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"28348719","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/28348719","id":0,"type":"PUBMED","article":{"title":"BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage.","authors":["Qin LX"," Tan JQ"," Zhang HN"," Rizwana K"," Lu JH"," Tang JG"," Jiang B"," Shen XM"," Guo JF"," Tang BS"," Tan LM"," Wang CY."],"journal":"Oxidative Medicine and Cellular Longevity","year":2017,"link":"http://www.ncbi.nlm.nih.gov/pubmed/28348719","id":"28348719","citationCount":1,"stringAuthors":"Qin LX,  Tan JQ,  Zhang HN,  Rizwana K,  Lu JH,  Tang JG,  Jiang B,  Shen XM,  Guo JF,  Tang BS,  Tan LM,  Wang CY."}},{"resource":"23186747","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":0,"type":"PUBMED","article":{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":5,"stringAuthors":"Yap YW,  Chen MJ,  Peng ZF,  Manikandan J,  Ng JM,  Llanos RM,  La Fontaine S,  Beart PM,  Cheung NS."}}],"name":"BAG5","targetParticipants":[{"resource":"BAG5","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=BAG5","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"28110601","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/28110601","id":0,"type":"PUBMED","article":{"title":"The effects of rotenone-induced toxicity via the NF-κB-iNOS pathway in rat liver.","authors":["Jiang X"," Feng X"," Huang H"," Liu L"," Qiao L"," Zhang B"," Yu W."],"journal":"Toxicology mechanisms and methods","year":2017,"link":"http://www.ncbi.nlm.nih.gov/pubmed/28110601","id":"28110601","citationCount":0,"stringAuthors":"Jiang X,  Feng X,  Huang H,  Liu L,  Qiao L,  Zhang B,  Yu W."}},{"resource":"25086357","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/25086357","id":0,"type":"PUBMED","article":{"title":"Downregulation of cystathionine β-synthase/hydrogen sulfide contributes to rotenone-induced microglia polarization toward M1 type.","authors":["Du C"," Jin M"," Hong Y"," Li Q"," Wang XH"," Xu JM"," Wang F"," Zhang Y"," Jia J"," Liu CF"," Hu LF."],"journal":"Biochemical and biophysical research communications","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25086357","id":"25086357","citationCount":8,"stringAuthors":"Du C,  Jin M,  Hong Y,  Li Q,  Wang XH,  Xu JM,  Wang F,  Zhang Y,  Jia J,  Liu CF,  Hu LF."}},{"resource":"24830863","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/24830863","id":0,"type":"PUBMED","article":{"title":"Rotenone, a mitochondrial respiratory complex I inhibitor, ameliorates lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice.","authors":["Ai Q"," Jing Y"," Jiang R"," Lin L"," Dai J"," Che Q"," Zhou D"," Jia M"," Wan J"," Zhang L."],"journal":"International immunopharmacology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24830863","id":"24830863","citationCount":8,"stringAuthors":"Ai Q,  Jing Y,  Jiang R,  Lin L,  Dai J,  Che Q,  Zhou D,  Jia M,  Wan J,  Zhang L."}},{"resource":"17356569","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/17356569","id":0,"type":"PUBMED","article":{"title":"Iptakalim alleviates rotenone-induced degeneration of dopaminergic neurons through inhibiting microglia-mediated neuroinflammation.","authors":["Zhou F"," Wu JY"," Sun XL"," Yao HH"," Ding JH"," Hu G."],"journal":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17356569","id":"17356569","citationCount":34,"stringAuthors":"Zhou F,  Wu JY,  Sun XL,  Yao HH,  Ding JH,  Hu G."}},{"resource":"24316229","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/24316229","id":0,"type":"PUBMED","article":{"title":"TNF-α mediates mitochondrial uncoupling and enhances ROS-dependent cell migration via NF-κB activation in liver cells.","authors":["Kastl L"," Sauer SW"," Ruppert T"," Beissbarth T"," Becker MS"," Süss D"," Krammer PH"," Gülow K."],"journal":"FEBS letters","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24316229","id":"24316229","citationCount":23,"stringAuthors":"Kastl L,  Sauer SW,  Ruppert T,  Beissbarth T,  Becker MS,  Süss D,  Krammer PH,  Gülow K."}},{"resource":"7532384","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/7532384","id":0,"type":"PUBMED","article":{"title":"Regulation of hepatic nitric oxide synthase by reactive oxygen intermediates and glutathione.","authors":["Duval DL"," Sieg DJ"," Billings RE."],"journal":"Archives of biochemistry and biophysics","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7532384","id":"7532384","citationCount":35,"stringAuthors":"Duval DL,  Sieg DJ,  Billings RE."}},{"resource":"19012619","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/19012619","id":0,"type":"PUBMED","article":{"title":"Opening of microglial K(ATP) channels inhibits rotenone-induced neuroinflammation.","authors":["Zhou F"," Yao HH"," Wu JY"," Ding JH"," Sun T"," Hu G."],"journal":"Journal of cellular and molecular medicine","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19012619","id":"19012619","citationCount":32,"stringAuthors":"Zhou F,  Yao HH,  Wu JY,  Ding JH,  Sun T,  Hu G."}},{"resource":"15720824","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/15720824","id":0,"type":"PUBMED","article":{"title":"Rotenone, a mitochondrial electron transport inhibitor, ameliorates ischemia-reperfusion-induced intestinal mucosal damage in rats.","authors":["Ichikawa H"," Takagi T"," Uchiyama K"," Higashihara H"," Katada K"," Isozaki Y"," Naito Y"," Yoshida N"," Yoshikawa T."],"journal":"Redox report : communications in free radical research","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15720824","id":"15720824","citationCount":7,"stringAuthors":"Ichikawa H,  Takagi T,  Uchiyama K,  Higashihara H,  Katada K,  Isozaki Y,  Naito Y,  Yoshida N,  Yoshikawa T."}},{"resource":"21807080","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","id":0,"type":"PUBMED","article":{"title":"An effective novel delivery strategy of rasagiline for Parkinson's disease.","authors":["Fernández M"," Negro S"," Slowing K"," Fernández-Carballido A"," Barcia E."],"journal":"International journal of pharmaceutics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","id":"21807080","citationCount":8,"stringAuthors":"Fernández M,  Negro S,  Slowing K,  Fernández-Carballido A,  Barcia E."}},{"resource":"23593274","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/23593274","id":0,"type":"PUBMED","article":{"title":"Resveratrol confers protection against rotenone-induced neurotoxicity by modulating myeloperoxidase levels in glial cells.","authors":["Chang CY"," Choi DK"," Lee DK"," Hong YJ"," Park EJ."],"journal":"PloS one","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23593274","id":"23593274","citationCount":8,"stringAuthors":"Chang CY,  Choi DK,  Lee DK,  Hong YJ,  Park EJ."}},{"resource":"16257489","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/16257489","id":0,"type":"PUBMED","article":{"title":"The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells.","authors":["Liu X"," Wu JY"," Zhou F"," Sun XL"," Yao HH"," Yang Y"," Ding JH"," Hu G."],"journal":"Neuroscience letters","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16257489","id":"16257489","citationCount":16,"stringAuthors":"Liu X,  Wu JY,  Zhou F,  Sun XL,  Yao HH,  Yang Y,  Ding JH,  Hu G."}},{"resource":"22623043","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/22623043","id":0,"type":"PUBMED","article":{"title":"Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice.","authors":["Kang HW"," Kim JM"," Cha MY"," Jung HC"," Song IS"," Kim JS."],"journal":"Digestive diseases and sciences","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22623043","id":"22623043","citationCount":18,"stringAuthors":"Kang HW,  Kim JM,  Cha MY,  Jung HC,  Song IS,  Kim JS."}},{"resource":"28389404","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/28389404","id":0,"type":"PUBMED","article":{"title":"Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis.","authors":["Anusha C"," Sumathi T"," Joseph LD."],"journal":"Chemico-biological interactions","year":2017,"link":"http://www.ncbi.nlm.nih.gov/pubmed/28389404","id":"28389404","citationCount":3,"stringAuthors":"Anusha C,  Sumathi T,  Joseph LD."}},{"resource":"23645222","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/23645222","id":0,"type":"PUBMED","article":{"title":"Rotenone could activate microglia through NFκB associated pathway.","authors":["Yuan YH"," Sun JD"," Wu MM"," Hu JF"," Peng SY"," Chen NH."],"journal":"Neurochemical research","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23645222","id":"23645222","citationCount":7,"stringAuthors":"Yuan YH,  Sun JD,  Wu MM,  Hu JF,  Peng SY,  Chen NH."}},{"resource":"25446674","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/25446674","id":0,"type":"PUBMED","article":{"title":"Saxagliptin: a novel antiparkinsonian approach.","authors":["Nassar NN"," Al-Shorbagy MY"," Arab HH"," Abdallah DM."],"journal":"Neuropharmacology","year":2015,"link":null,"id":"25446674","citationCount":5,"stringAuthors":"Nassar NN,  Al-Shorbagy MY,  Arab HH,  Abdallah DM."}},{"resource":"25481089","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/25481089","id":0,"type":"PUBMED","article":{"title":"Neuroprotective effects of bee venom acupuncture therapy against rotenone-induced oxidative stress and apoptosis.","authors":["Khalil WK"," Assaf N"," ElShebiney SA"," Salem NA."],"journal":"Neurochemistry international","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25481089","id":"25481089","citationCount":5,"stringAuthors":"Khalil WK,  Assaf N,  ElShebiney SA,  Salem NA."}},{"resource":"25502462","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/25502462","id":0,"type":"PUBMED","article":{"title":"Ursodeoxycholic Acid Ameliorates Apoptotic Cascade in the Rotenone Model of Parkinson's Disease: Modulation of Mitochondrial Perturbations.","authors":["Abdelkader NF"," Safar MM"," Salem HA."],"journal":"Molecular neurobiology","year":2016,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25502462","id":"25502462","citationCount":2,"stringAuthors":"Abdelkader NF,  Safar MM,  Salem HA."}},{"resource":"15135310","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/15135310","id":0,"type":"PUBMED","article":{"title":"Inverse gene expression patterns for macrophage activating hepatotoxicants and peroxisome proliferators in rat liver.","authors":["McMillian M"," Nie AY"," Parker JB"," Leone A"," Kemmerer M"," Bryant S"," Herlich J"," Yieh L"," Bittner A"," Liu X"," Wan J"," Johnson MD."],"journal":"Biochemical pharmacology","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15135310","id":"15135310","citationCount":27,"stringAuthors":"McMillian M,  Nie AY,  Parker JB,  Leone A,  Kemmerer M,  Bryant S,  Herlich J,  Yieh L,  Bittner A,  Liu X,  Wan J,  Johnson MD."}},{"resource":"10973919","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/10973919","id":0,"type":"PUBMED","article":{"title":"Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by reactive oxygen species.","authors":["Deshpande SS"," Angkeow P"," Huang J"," Ozaki M"," Irani K."],"journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10973919","id":"10973919","citationCount":97,"stringAuthors":"Deshpande SS,  Angkeow P,  Huang J,  Ozaki M,  Irani K."}},{"resource":"10878378","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/10878378","id":0,"type":"PUBMED","article":{"title":"Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin.","authors":["Chandel NS"," Trzyna WC"," McClintock DS"," Schumacker PT."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10878378","id":"10878378","citationCount":153,"stringAuthors":"Chandel NS,  Trzyna WC,  McClintock DS,  Schumacker PT."}},{"resource":"17015749","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/17015749","id":0,"type":"PUBMED","article":{"title":"Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.","authors":["Nair AS"," Shishodia S"," Ahn KS"," Kunnumakkara AB"," Sethi G"," Aggarwal BB."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17015749","id":"17015749","citationCount":26,"stringAuthors":"Nair AS,  Shishodia S,  Ahn KS,  Kunnumakkara AB,  Sethi G,  Aggarwal BB."}}],"name":"TNF","targetParticipants":[{"resource":"TNF","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=TNF","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"15796199","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/15796199","id":0,"type":"PUBMED","article":{"title":"In vitro search for synergy between flavonoids and epirubicin on multidrug-resistant cancer cells.","authors":["Gyémánt N"," Tanaka M"," Antus S"," Hohmann J"," Csuka O"," Mándoky L"," Molnár J."],"journal":"In vivo (Athens, Greece)","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15796199","id":"15796199","citationCount":15,"stringAuthors":"Gyémánt N,  Tanaka M,  Antus S,  Hohmann J,  Csuka O,  Mándoky L,  Molnár J."}}],"name":"ABCB1","targetParticipants":[{"resource":"ABCB1","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ABCB1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"12177198","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/12177198","id":0,"type":"PUBMED","article":{"title":"An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.","authors":["Sherer TB"," Betarbet R"," Stout AK"," Lund S"," Baptista M"," Panov AV"," Cookson MR"," Greenamyre JT."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12177198","id":"12177198","citationCount":240,"stringAuthors":"Sherer TB,  Betarbet R,  Stout AK,  Lund S,  Baptista M,  Panov AV,  Cookson MR,  Greenamyre JT."}},{"resource":"16219024","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/16219024","id":0,"type":"PUBMED","article":{"title":"The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy.","authors":["Höglinger GU"," Lannuzel A"," Khondiker ME"," Michel PP"," Duyckaerts C"," Féger J"," Champy P"," Prigent A"," Medja F"," Lombes A"," Oertel WH"," Ruberg M"," Hirsch EC."],"journal":"Journal of neurochemistry","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16219024","id":"16219024","citationCount":76,"stringAuthors":"Höglinger GU,  Lannuzel A,  Khondiker ME,  Michel PP,  Duyckaerts C,  Féger J,  Champy P,  Prigent A,  Medja F,  Lombes A,  Oertel WH,  Ruberg M,  Hirsch EC."}},{"resource":"16439141","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/16439141","id":0,"type":"PUBMED","article":{"title":"Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system.","authors":["Betarbet R"," Canet-Aviles RM"," Sherer TB"," Mastroberardino PG"," McLendon C"," Kim JH"," Lund S"," Na HM"," Taylor G"," Bence NF"," Kopito R"," Seo BB"," Yagi T"," Yagi A"," Klinefelter G"," Cookson MR"," Greenamyre JT."],"journal":"Neurobiology of disease","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16439141","id":"16439141","citationCount":131,"stringAuthors":"Betarbet R,  Canet-Aviles RM,  Sherer TB,  Mastroberardino PG,  McLendon C,  Kim JH,  Lund S,  Na HM,  Taylor G,  Bence NF,  Kopito R,  Seo BB,  Yagi T,  Yagi A,  Klinefelter G,  Cookson MR,  Greenamyre JT."}},{"resource":"23984410","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/23984410","id":0,"type":"PUBMED","article":{"title":"Rotenone upregulates alpha-synuclein and myocyte enhancer factor 2D independently from lysosomal degradation inhibition.","authors":["Sala G"," Arosio A"," Stefanoni G"," Melchionda L"," Riva C"," Marinig D"," Brighina L"," Ferrarese C."],"journal":"BioMed Research International","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23984410","id":"23984410","citationCount":8,"stringAuthors":"Sala G,  Arosio A,  Stefanoni G,  Melchionda L,  Riva C,  Marinig D,  Brighina L,  Ferrarese C."}},{"resource":"18289173","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","id":0,"type":"PUBMED","article":{"title":"Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats.","authors":["Lin CH"," Huang JY"," Ching CH"," Chuang JI."],"journal":"Journal of pineal research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","id":"18289173","citationCount":32,"stringAuthors":"Lin CH,  Huang JY,  Ching CH,  Chuang JI."}},{"resource":"27133439","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/27133439","id":0,"type":"PUBMED","article":{"title":"Rotenone down-regulates HSPA8/hsc70 chaperone protein in vitro: A new possible toxic mechanism contributing to Parkinson's disease.","authors":["Sala G"," Marinig D"," Riva C"," Arosio A"," Stefanoni G"," Brighina L"," Formenti M"," Alberghina L"," Colangelo AM"," Ferrarese C."],"journal":"Neurotoxicology","year":2016,"link":"http://www.ncbi.nlm.nih.gov/pubmed/27133439","id":"27133439","citationCount":2,"stringAuthors":"Sala G,  Marinig D,  Riva C,  Arosio A,  Stefanoni G,  Brighina L,  Formenti M,  Alberghina L,  Colangelo AM,  Ferrarese C."}},{"resource":"18514418","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/18514418","id":0,"type":"PUBMED","article":{"title":"Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells.","authors":["Shavali S"," Brown-Borg HM"," Ebadi M"," Porter J."],"journal":"Neuroscience letters","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18514418","id":"18514418","citationCount":62,"stringAuthors":"Shavali S,  Brown-Borg HM,  Ebadi M,  Porter J."}},{"resource":"12151787","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/12151787","id":0,"type":"PUBMED","article":{"title":"Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro.","authors":["Lehmensiek V"," Tan EM"," Schwarz J"," Storch A."],"journal":"Neuroreport","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12151787","id":"12151787","citationCount":13,"stringAuthors":"Lehmensiek V,  Tan EM,  Schwarz J,  Storch A."}},{"resource":"23205266","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/23205266","id":0,"type":"PUBMED","article":{"title":"Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice.","authors":["Pan-Montojo F"," Schwarz M"," Winkler C"," Arnhold M"," O'Sullivan GA"," Pal A"," Said J"," Marsico G"," Verbavatz JM"," Rodrigo-Angulo M"," Gille G"," Funk RH"," Reichmann H."],"journal":"Scientific reports","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23205266","id":"23205266","citationCount":71,"stringAuthors":"Pan-Montojo F,  Schwarz M,  Winkler C,  Arnhold M,  O'Sullivan GA,  Pal A,  Said J,  Marsico G,  Verbavatz JM,  Rodrigo-Angulo M,  Gille G,  Funk RH,  Reichmann H."}},{"resource":"26031332","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/26031332","id":0,"type":"PUBMED","article":{"title":"Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation.","authors":["Hou YS"," Guan JJ"," Xu HD"," Wu F"," Sheng R"," Qin ZH."],"journal":"Molecular and cellular biology","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26031332","id":"26031332","citationCount":5,"stringAuthors":"Hou YS,  Guan JJ,  Xu HD,  Wu F,  Sheng R,  Qin ZH."}},{"resource":"17041725","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/17041725","id":0,"type":"PUBMED","article":{"title":"[Overexpression of alpha-synuclein in SH-SY5Y cells partially protected against oxidative stress induced by rotenone].","authors":["Liu YY"," Zhao HY"," Zhao CL"," Duan CL"," Lu LL"," Yang H."],"journal":"Sheng li xue bao : [Acta physiologica Sinica]","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17041725","id":"17041725","citationCount":0,"stringAuthors":"Liu YY,  Zhao HY,  Zhao CL,  Duan CL,  Lu LL,  Yang H."}},{"resource":"23153578","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/23153578","id":0,"type":"PUBMED","article":{"title":"Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment.","authors":["Cannon JR"," Geghman KD"," Tapias V"," Sew T"," Dail MK"," Li C"," Greenamyre JT."],"journal":"Experimental neurology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23153578","id":"23153578","citationCount":17,"stringAuthors":"Cannon JR,  Geghman KD,  Tapias V,  Sew T,  Dail MK,  Li C,  Greenamyre JT."}},{"resource":"24002177","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/24002177","id":0,"type":"PUBMED","article":{"title":"14-3-3 Proteins in the regulation of rotenone-induced neurotoxicity might be via its isoform 14-3-3epsilon's involvement in autophagy.","authors":["Sai Y"," Peng K"," Ye F"," Zhao X"," Zhao Y"," Zou Z"," Cao J"," Dong Z."],"journal":"Cellular and molecular neurobiology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24002177","id":"24002177","citationCount":1,"stringAuthors":"Sai Y,  Peng K,  Ye F,  Zhao X,  Zhao Y,  Zou Z,  Cao J,  Dong Z."}},{"resource":"16239214","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/16239214","id":0,"type":"PUBMED","article":{"title":"Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.","authors":["Ved R"," Saha S"," Westlund B"," Perier C"," Burnam L"," Sluder A"," Hoener M"," Rodrigues CM"," Alfonso A"," Steer C"," Liu L"," Przedborski S"," Wolozin B."],"journal":"The Journal of biological chemistry","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16239214","id":"16239214","citationCount":120,"stringAuthors":"Ved R,  Saha S,  Westlund B,  Perier C,  Burnam L,  Sluder A,  Hoener M,  Rodrigues CM,  Alfonso A,  Steer C,  Liu L,  Przedborski S,  Wolozin B."}},{"resource":"11445065","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/11445065","id":0,"type":"PUBMED","article":{"title":"Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease.","authors":["Uversky VN"," Li J"," Fink AL."],"journal":"FEBS letters","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11445065","id":"11445065","citationCount":124,"stringAuthors":"Uversky VN,  Li J,  Fink AL."}},{"resource":"28389404","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/28389404","id":0,"type":"PUBMED","article":{"title":"Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis.","authors":["Anusha C"," Sumathi T"," Joseph LD."],"journal":"Chemico-biological interactions","year":2017,"link":"http://www.ncbi.nlm.nih.gov/pubmed/28389404","id":"28389404","citationCount":3,"stringAuthors":"Anusha C,  Sumathi T,  Joseph LD."}},{"resource":"19857570","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/19857570","id":0,"type":"PUBMED","article":{"title":"Oxidants induce alternative splicing of alpha-synuclein: Implications for Parkinson's disease.","authors":["Kalivendi SV"," Yedlapudi D"," Hillard CJ"," Kalyanaraman B."],"journal":"Free radical biology & medicine","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19857570","id":"19857570","citationCount":22,"stringAuthors":"Kalivendi SV,  Yedlapudi D,  Hillard CJ,  Kalyanaraman B."}},{"resource":"17459145","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/17459145","id":0,"type":"PUBMED","article":{"title":"Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.","authors":["Inden M"," Kitamura Y"," Takeuchi H"," Yanagida T"," Takata K"," Kobayashi Y"," Taniguchi T"," Yoshimoto K"," Kaneko M"," Okuma Y"," Taira T"," Ariga H"," Shimohama S."],"journal":"Journal of neurochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17459145","id":"17459145","citationCount":68,"stringAuthors":"Inden M,  Kitamura Y,  Takeuchi H,  Yanagida T,  Takata K,  Kobayashi Y,  Taniguchi T,  Yoshimoto K,  Kaneko M,  Okuma Y,  Taira T,  Ariga H,  Shimohama S."}},{"resource":"25430725","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/25430725","id":0,"type":"PUBMED","article":{"title":"Daily rhythms of serotonin metabolism and the expression of clock genes in suprachiasmatic nucleus of rotenone-induced Parkinson's disease male Wistar rat model and effect of melatonin administration.","authors":["Mattam U"," Jagota A."],"journal":"Biogerontology","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25430725","id":"25430725","citationCount":3,"stringAuthors":"Mattam U,  Jagota A."}},{"resource":"27585560","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/27585560","id":0,"type":"PUBMED","article":{"title":"Interaction between subclinical doses of the Parkinson's disease associated gene, α-synuclein, and the pesticide, rotenone, precipitates motor dysfunction and nigrostriatal neurodegeneration in rats.","authors":["Naughton C"," O'Toole D"," Kirik D"," Dowd E."],"journal":"Behavioural brain research","year":2017,"link":"http://www.ncbi.nlm.nih.gov/pubmed/27585560","id":"27585560","citationCount":2,"stringAuthors":"Naughton C,  O'Toole D,  Kirik D,  Dowd E."}},{"resource":"20414966","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/20414966","id":0,"type":"PUBMED","article":{"title":"Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease.","authors":["Zhang H"," Jia H"," Liu J"," Ao N"," Yan B"," Shen W"," Wang X"," Li X"," Luo C"," Liu J."],"journal":"Journal of cellular and molecular medicine","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20414966","id":"20414966","citationCount":21,"stringAuthors":"Zhang H,  Jia H,  Liu J,  Ao N,  Yan B,  Shen W,  Wang X,  Li X,  Luo C,  Liu J."}},{"resource":"15280438","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/15280438","id":0,"type":"PUBMED","article":{"title":"Rotenone induces apoptosis via activation of bad in human dopaminergic SH-SY5Y cells.","authors":["Watabe M"," Nakaki T."],"journal":"The Journal of pharmacology and experimental therapeutics","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15280438","id":"15280438","citationCount":27,"stringAuthors":"Watabe M,  Nakaki T."}},{"resource":"27053302","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/27053302","id":0,"type":"PUBMED","article":{"title":"SIRT3 Acts as a Neuroprotective Agent in Rotenone-Induced Parkinson Cell Model.","authors":["Zhang JY"," Deng YN"," Zhang M"," Su H"," Qu QM."],"journal":"Neurochemical research","year":2016,"link":"http://www.ncbi.nlm.nih.gov/pubmed/27053302","id":"27053302","citationCount":2,"stringAuthors":"Zhang JY,  Deng YN,  Zhang M,  Su H,  Qu QM."}},{"resource":"20464527","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/20464527","id":0,"type":"PUBMED","article":{"title":"α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment.","authors":["George S"," Mok SS"," Nurjono M"," Ayton S"," Finkelstein DI"," Masters CL"," Li QX"," Culvenor JG."],"journal":"Journal of molecular neuroscience : MN","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20464527","id":"20464527","citationCount":14,"stringAuthors":"George S,  Mok SS,  Nurjono M,  Ayton S,  Finkelstein DI,  Masters CL,  Li QX,  Culvenor JG."}},{"resource":"19628769","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/19628769","id":0,"type":"PUBMED","article":{"title":"Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein.","authors":["Yu WH"," Dorado B"," Figueroa HY"," Wang L"," Planel E"," Cookson MR"," Clark LN"," Duff KE."],"journal":"The American journal of pathology","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19628769","id":"19628769","citationCount":65,"stringAuthors":"Yu WH,  Dorado B,  Figueroa HY,  Wang L,  Planel E,  Cookson MR,  Clark LN,  Duff KE."}},{"resource":"17690729","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/17690729","id":0,"type":"PUBMED","article":{"title":"alpha-Synuclein redistributed and aggregated in rotenone-induced Parkinson's disease rats.","authors":["Feng Y"," Liang ZH"," Wang T"," Qiao X"," Liu HJ"," Sun SG."],"journal":"Neuroscience bulletin","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17690729","id":"17690729","citationCount":8,"stringAuthors":"Feng Y,  Liang ZH,  Wang T,  Qiao X,  Liu HJ,  Sun SG."}},{"resource":"11100151","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/11100151","id":0,"type":"PUBMED","article":{"title":"Chronic systemic pesticide exposure reproduces features of Parkinson's disease.","authors":["Betarbet R"," Sherer TB"," MacKenzie G"," Garcia-Osuna M"," Panov AV"," Greenamyre JT."],"journal":"Nature neuroscience","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11100151","id":"11100151","citationCount":1330,"stringAuthors":"Betarbet R,  Sherer TB,  MacKenzie G,  Garcia-Osuna M,  Panov AV,  Greenamyre JT."}},{"resource":"23244436","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/23244436","id":0,"type":"PUBMED","article":{"title":"Environmental toxicants as extrinsic epigenetic factors for parkinsonism: studies employing transgenic C. elegans model.","authors":["Jadiya P"," Nazir A."],"journal":"CNS & neurological disorders drug targets","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23244436","id":"23244436","citationCount":5,"stringAuthors":"Jadiya P,  Nazir A."}},{"resource":"17131421","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/17131421","id":0,"type":"PUBMED","article":{"title":"RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport.","authors":["Fountaine TM"," Wade-Martins R."],"journal":"Journal of neuroscience research","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17131421","id":"17131421","citationCount":56,"stringAuthors":"Fountaine TM,  Wade-Martins R."}},{"resource":"22319455","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/22319455","id":0,"type":"PUBMED","article":{"title":"The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity.","authors":["Butler EK"," Voigt A"," Lutz AK"," Toegel JP"," Gerhardt E"," Karsten P"," Falkenburger B"," Reinartz A"," Winklhofer KF"," Schulz JB."],"journal":"PLoS genetics","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22319455","id":"22319455","citationCount":38,"stringAuthors":"Butler EK,  Voigt A,  Lutz AK,  Toegel JP,  Gerhardt E,  Karsten P,  Falkenburger B,  Reinartz A,  Winklhofer KF,  Schulz JB."}},{"resource":"26075822","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/26075822","id":0,"type":"PUBMED","article":{"title":"shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model.","authors":["Zharikov AD"," Cannon JR"," Tapias V"," Bai Q"," Horowitz MP"," Shah V"," El Ayadi A"," Hastings TG"," Greenamyre JT"," Burton EA."],"journal":"The Journal of clinical investigation","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26075822","id":"26075822","citationCount":9,"stringAuthors":"Zharikov AD,  Cannon JR,  Tapias V,  Bai Q,  Horowitz MP,  Shah V,  El Ayadi A,  Hastings TG,  Greenamyre JT,  Burton EA."}},{"resource":"15114628","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/15114628","id":0,"type":"PUBMED","article":{"title":"1-Benzyl-1,2,3,4-tetrahydroisoquinoline, a Parkinsonism-inducing endogenous toxin, increases alpha-synuclein expression and causes nuclear damage in human dopaminergic cells.","authors":["Shavali S"," Carlson EC"," Swinscoe JC"," Ebadi M."],"journal":"Journal of neuroscience research","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15114628","id":"15114628","citationCount":23,"stringAuthors":"Shavali S,  Carlson EC,  Swinscoe JC,  Ebadi M."}},{"resource":"19114014","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/19114014","id":0,"type":"PUBMED","article":{"title":"Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells.","authors":["Borland MK"," Trimmer PA"," Rubinstein JD"," Keeney PM"," Mohanakumar K"," Liu L"," Bennett JP."],"journal":"Molecular neurodegeneration","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19114014","id":"19114014","citationCount":44,"stringAuthors":"Borland MK,  Trimmer PA,  Rubinstein JD,  Keeney PM,  Mohanakumar K,  Liu L,  Bennett JP."}},{"resource":"26963176","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/26963176","id":0,"type":"PUBMED","article":{"title":"Tracking micro-optical resonances for identifying and sensing novel procaspase-3 protein marker released from cell cultures in response to toxins.","authors":["Chen YJ"," Xiang W"," Klucken J"," Vollmer F."],"journal":"Nanotechnology","year":2016,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26963176","id":"26963176","citationCount":1,"stringAuthors":"Chen YJ,  Xiang W,  Klucken J,  Vollmer F."}},{"resource":"19626387","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/19626387","id":0,"type":"PUBMED","article":{"title":"Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synuclein.","authors":["Monti B"," Gatta V"," Piretti F"," Raffaelli SS"," Virgili M"," Contestabile A."],"journal":"Neurotoxicity research","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19626387","id":"19626387","citationCount":49,"stringAuthors":"Monti B,  Gatta V,  Piretti F,  Raffaelli SS,  Virgili M,  Contestabile A."}},{"resource":"24290359","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/24290359","id":0,"type":"PUBMED","article":{"title":"Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.","authors":["Ryan SD"," Dolatabadi N"," Chan SF"," Zhang X"," Akhtar MW"," Parker J"," Soldner F"," Sunico CR"," Nagar S"," Talantova M"," Lee B"," Lopez K"," Nutter A"," Shan B"," Molokanova E"," Zhang Y"," Han X"," Nakamura T"," Masliah E"," Yates JR"," Nakanishi N"," Andreyev AY"," Okamoto S"," Jaenisch R"," Ambasudhan R"," Lipton SA."],"journal":"Cell","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24290359","id":"24290359","citationCount":88,"stringAuthors":"Ryan SD,  Dolatabadi N,  Chan SF,  Zhang X,  Akhtar MW,  Parker J,  Soldner F,  Sunico CR,  Nagar S,  Talantova M,  Lee B,  Lopez K,  Nutter A,  Shan B,  Molokanova E,  Zhang Y,  Han X,  Nakamura T,  Masliah E,  Yates JR,  Nakanishi N,  Andreyev AY,  Okamoto S,  Jaenisch R,  Ambasudhan R,  Lipton SA."}},{"resource":"25433145","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/25433145","id":0,"type":"PUBMED","article":{"title":"The molecular mechanism of rotenone-induced α-synuclein aggregation: emphasizing the role of the calcium/GSK3β pathway.","authors":["Yuan YH"," Yan WF"," Sun JD"," Huang JY"," Mu Z"," Chen NH."],"journal":"Toxicology letters","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25433145","id":"25433145","citationCount":8,"stringAuthors":"Yuan YH,  Yan WF,  Sun JD,  Huang JY,  Mu Z,  Chen NH."}},{"resource":"15099020","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/15099020","id":0,"type":"PUBMED","article":{"title":"Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice.","authors":["Dalfó E"," Gómez-Isla T"," Rosa JL"," Nieto Bodelón M"," Cuadrado Tejedor M"," Barrachina M"," Ambrosio S"," Ferrer I."],"journal":"Journal of neuropathology and experimental neurology","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15099020","id":"15099020","citationCount":45,"stringAuthors":"Dalfó E,  Gómez-Isla T,  Rosa JL,  Nieto Bodelón M,  Cuadrado Tejedor M,  Barrachina M,  Ambrosio S,  Ferrer I."}},{"resource":"23535362","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/23535362","id":0,"type":"PUBMED","article":{"title":"Specific pesticide-dependent increases in α-synuclein levels in human neuroblastoma (SH-SY5Y) and melanoma (SK-MEL-2) cell lines.","authors":["Chorfa A"," Bétemps D"," Morignat E"," Lazizzera C"," Hogeveen K"," Andrieu T"," Baron T."],"journal":"Toxicological sciences : an official journal of the Society of Toxicology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23535362","id":"23535362","citationCount":11,"stringAuthors":"Chorfa A,  Bétemps D,  Morignat E,  Lazizzera C,  Hogeveen K,  Andrieu T,  Baron T."}}],"name":"SNCA","targetParticipants":[{"resource":"SNCA","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SNCA","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"27979718","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/27979718","id":0,"type":"PUBMED","article":{"title":"Neonatal rotenone lesions cause onset of hyperactivity during juvenile and adulthood in the rat.","authors":["Ishido M"," Suzuki J"," Masuo Y."],"journal":"Toxicology letters","year":2017,"link":"http://www.ncbi.nlm.nih.gov/pubmed/27979718","id":"27979718","citationCount":0,"stringAuthors":"Ishido M,  Suzuki J,  Masuo Y."}}],"name":"HSPA1A","targetParticipants":[{"resource":"HSPA1A","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSPA1A","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"28389404","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/28389404","id":0,"type":"PUBMED","article":{"title":"Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis.","authors":["Anusha C"," Sumathi T"," Joseph LD."],"journal":"Chemico-biological interactions","year":2017,"link":"http://www.ncbi.nlm.nih.gov/pubmed/28389404","id":"28389404","citationCount":3,"stringAuthors":"Anusha C,  Sumathi T,  Joseph LD."}},{"resource":"18289173","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","id":0,"type":"PUBMED","article":{"title":"Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats.","authors":["Lin CH"," Huang JY"," Ching CH"," Chuang JI."],"journal":"Journal of pineal research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","id":"18289173","citationCount":32,"stringAuthors":"Lin CH,  Huang JY,  Ching CH,  Chuang JI."}},{"resource":"20887679","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/20887679","id":0,"type":"PUBMED","article":{"title":"Dopamine Dâ‚� and Dâ‚‚ receptor subtypes functional regulation in corpus striatum of unilateral rotenone lesioned Parkinson's rat model: effect of serotonin, dopamine and norepinephrine.","authors":["Paul J"," Nandhu MS"," Kuruvilla KP"," Paulose CS."],"journal":"Neurological research","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20887679","id":"20887679","citationCount":2,"stringAuthors":"Paul J,  Nandhu MS,  Kuruvilla KP,  Paulose CS."}}],"name":"DRD2","targetParticipants":[{"resource":"DRD2","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DRD2","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"20887679","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/20887679","id":0,"type":"PUBMED","article":{"title":"Dopamine Dâ‚� and Dâ‚‚ receptor subtypes functional regulation in corpus striatum of unilateral rotenone lesioned Parkinson's rat model: effect of serotonin, dopamine and norepinephrine.","authors":["Paul J"," Nandhu MS"," Kuruvilla KP"," Paulose CS."],"journal":"Neurological research","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20887679","id":"20887679","citationCount":2,"stringAuthors":"Paul J,  Nandhu MS,  Kuruvilla KP,  Paulose CS."}}],"name":"DRD1","targetParticipants":[{"resource":"DRD1","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DRD1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"18646205","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/18646205","id":0,"type":"PUBMED","article":{"title":"Pitx3-transfected astrocytes secrete brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor and protect dopamine neurons in mesencephalon cultures.","authors":["Yang D"," Peng C"," Li X"," Fan X"," Li L"," Ming M"," Chen S"," Le W."],"journal":"Journal of neuroscience research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18646205","id":"18646205","citationCount":13,"stringAuthors":"Yang D,  Peng C,  Li X,  Fan X,  Li L,  Ming M,  Chen S,  Le W."}},{"resource":"17442543","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/17442543","id":0,"type":"PUBMED","article":{"title":"Differential effects of classical and atypical antipsychotic drugs on rotenone-induced neurotoxicity in PC12 cells.","authors":["Tan QR"," Wang XZ"," Wang CY"," Liu XJ"," Chen YC"," Wang HH"," Zhang RG"," Zhen XC"," Tong Y"," Zhang ZJ."],"journal":"European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17442543","id":"17442543","citationCount":12,"stringAuthors":"Tan QR,  Wang XZ,  Wang CY,  Liu XJ,  Chen YC,  Wang HH,  Zhang RG,  Zhen XC,  Tong Y,  Zhang ZJ."}},{"resource":"28389404","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/28389404","id":0,"type":"PUBMED","article":{"title":"Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis.","authors":["Anusha C"," Sumathi T"," Joseph LD."],"journal":"Chemico-biological interactions","year":2017,"link":"http://www.ncbi.nlm.nih.gov/pubmed/28389404","id":"28389404","citationCount":3,"stringAuthors":"Anusha C,  Sumathi T,  Joseph LD."}},{"resource":"25446674","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/25446674","id":0,"type":"PUBMED","article":{"title":"Saxagliptin: a novel antiparkinsonian approach.","authors":["Nassar NN"," Al-Shorbagy MY"," Arab HH"," Abdallah DM."],"journal":"Neuropharmacology","year":2015,"link":null,"id":"25446674","citationCount":5,"stringAuthors":"Nassar NN,  Al-Shorbagy MY,  Arab HH,  Abdallah DM."}},{"resource":"17209049","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/17209049","id":0,"type":"PUBMED","article":{"title":"AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro.","authors":["Bogush A"," Pedrini S"," Pelta-Heller J"," Chan T"," Yang Q"," Mao Z"," Sluzas E"," Gieringer T"," Ehrlich ME."],"journal":"The Journal of biological chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17209049","id":"17209049","citationCount":30,"stringAuthors":"Bogush A,  Pedrini S,  Pelta-Heller J,  Chan T,  Yang Q,  Mao Z,  Sluzas E,  Gieringer T,  Ehrlich ME."}},{"resource":"23189969","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/23189969","id":0,"type":"PUBMED","article":{"title":"Transient exposure to echinacoside is sufficient to activate Trk signaling and protect neuronal cells from rotenone.","authors":["Zhu M"," Lu C"," Li W."],"journal":"Journal of neurochemistry","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23189969","id":"23189969","citationCount":8,"stringAuthors":"Zhu M,  Lu C,  Li W."}}],"name":"BDNF","targetParticipants":[{"resource":"BDNF","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=BDNF","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"17702527","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/17702527","id":0,"type":"PUBMED","article":{"title":"Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screening.","authors":["Coe KJ"," Jia Y"," Ho HK"," Rademacher P"," Bammler TK"," Beyer RP"," Farin FM"," Woodke L"," Plymate SR"," Fausto N"," Nelson SD."],"journal":"Chemical research in toxicology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17702527","id":"17702527","citationCount":23,"stringAuthors":"Coe KJ,  Jia Y,  Ho HK,  Rademacher P,  Bammler TK,  Beyer RP,  Farin FM,  Woodke L,  Plymate SR,  Fausto N,  Nelson SD."}},{"resource":"22659318","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/22659318","id":0,"type":"PUBMED","article":{"title":"Cadmium-induced apoptosis in the BJAB human B cell line: involvement of PKC/ERK1/2/JNK signaling pathways in HO-1 expression.","authors":["Nemmiche S"," Chabane-Sari D"," Kadri M"," Guiraud P."],"journal":"Toxicology","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22659318","id":"22659318","citationCount":16,"stringAuthors":"Nemmiche S,  Chabane-Sari D,  Kadri M,  Guiraud P."}},{"resource":"17657281","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":0,"type":"PUBMED","article":{"title":"The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.","authors":["Panee J"," Liu W"," Nakamura K"," Berry MJ."],"journal":"International journal of biological sciences","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":"17657281","citationCount":13,"stringAuthors":"Panee J,  Liu W,  Nakamura K,  Berry MJ."}},{"resource":"28145852","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/28145852","id":0,"type":"PUBMED","article":{"title":"Safranal prevents rotenone-induced oxidative stress and apoptosis in an in vitro model of Parkinson's disease through regulating Keap1/Nrf2 signaling pathway.","authors":["Pan PK"," Qiao LY"," Wen XN."],"journal":"Cellular and molecular biology (Noisy-le-Grand, France)","year":2016,"link":"http://www.ncbi.nlm.nih.gov/pubmed/28145852","id":"28145852","citationCount":0,"stringAuthors":"Pan PK,  Qiao LY,  Wen XN."}},{"resource":"19131585","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/19131585","id":0,"type":"PUBMED","article":{"title":"Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells.","authors":["Han Z"," Varadharaj S"," Giedt RJ"," Zweier JL"," Szeto HH"," Alevriadou BR."],"journal":"The Journal of pharmacology and experimental therapeutics","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19131585","id":"19131585","citationCount":34,"stringAuthors":"Han Z,  Varadharaj S,  Giedt RJ,  Zweier JL,  Szeto HH,  Alevriadou BR."}},{"resource":"28245986","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/28245986","id":0,"type":"PUBMED","article":{"title":"DJ-1 regulating PI3K-Nrf2 signaling plays a significant role in bibenzyl compound 20C-mediated neuroprotection against rotenone-induced oxidative insult.","authors":["Zhang XL"," Yuan YH"," Shao QH"," Wang ZZ"," Zhu CG"," Shi JG"," Ma KL"," Yan X"," Chen NH."],"journal":"Toxicology letters","year":2017,"link":"http://www.ncbi.nlm.nih.gov/pubmed/28245986","id":"28245986","citationCount":0,"stringAuthors":"Zhang XL,  Yuan YH,  Shao QH,  Wang ZZ,  Zhu CG,  Shi JG,  Ma KL,  Yan X,  Chen NH."}},{"resource":"26276080","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/26276080","id":0,"type":"PUBMED","article":{"title":"Pyrroloquinoline quinone-conferred neuroprotection in rotenone models of Parkinson's disease.","authors":["Qin J"," Wu M"," Yu S"," Gao X"," Zhang J"," Dong X"," Ji J"," Zhang Y"," Zhou L"," Zhang Q"," Ding F."],"journal":"Toxicology letters","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26276080","id":"26276080","citationCount":3,"stringAuthors":"Qin J,  Wu M,  Yu S,  Gao X,  Zhang J,  Dong X,  Ji J,  Zhang Y,  Zhou L,  Zhang Q,  Ding F."}},{"resource":"27180985","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/27180985","id":0,"type":"PUBMED","article":{"title":"20C, a bibenzyl compound isolated from Gastrodia elata, protects PC12 cells against rotenone-induced apoptosis via activation of the Nrf2/ARE/HO-1 signaling pathway.","authors":["Huang JY"," Yuan YH"," Yan JQ"," Wang YN"," Chu SF"," Zhu CG"," Guo QL"," Shi JG"," Chen NH."],"journal":"Acta pharmacologica Sinica","year":2016,"link":"http://www.ncbi.nlm.nih.gov/pubmed/27180985","id":"27180985","citationCount":2,"stringAuthors":"Huang JY,  Yuan YH,  Yan JQ,  Wang YN,  Chu SF,  Zhu CG,  Guo QL,  Shi JG,  Chen NH."}},{"resource":"24451142","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/24451142","id":0,"type":"PUBMED","article":{"title":"Resveratrol partially prevents rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through induction of heme oxygenase-1 dependent autophagy.","authors":["Lin TK"," Chen SD"," Chuang YC"," Lin HY"," Huang CR"," Chuang JH"," Wang PW"," Huang ST"," Tiao MM"," Chen JB"," Liou CW."],"journal":"International journal of molecular sciences","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24451142","id":"24451142","citationCount":27,"stringAuthors":"Lin TK,  Chen SD,  Chuang YC,  Lin HY,  Huang CR,  Chuang JH,  Wang PW,  Huang ST,  Tiao MM,  Chen JB,  Liou CW."}},{"resource":"23186747","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":0,"type":"PUBMED","article":{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":5,"stringAuthors":"Yap YW,  Chen MJ,  Peng ZF,  Manikandan J,  Ng JM,  Llanos RM,  La Fontaine S,  Beart PM,  Cheung NS."}}],"name":"HMOX1","targetParticipants":[{"resource":"HMOX1","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HMOX1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"20940149","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","id":0,"type":"PUBMED","article":{"title":"DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.","authors":["Thomas KJ"," McCoy MK"," Blackinton J"," Beilina A"," van der Brug M"," Sandebring A"," Miller D"," Maric D"," Cedazo-Minguez A"," Cookson MR."],"journal":"Human molecular genetics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","id":"20940149","citationCount":148,"stringAuthors":"Thomas KJ,  McCoy MK,  Blackinton J,  Beilina A,  van der Brug M,  Sandebring A,  Miller D,  Maric D,  Cedazo-Minguez A,  Cookson MR."}},{"resource":"17687034","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/17687034","id":0,"type":"PUBMED","article":{"title":"Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities.","authors":["Wang C"," Lu R"," Ouyang X"," Ho MW"," Chia W"," Yu F"," Lim KL."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17687034","id":"17687034","citationCount":52,"stringAuthors":"Wang C,  Lu R,  Ouyang X,  Ho MW,  Chia W,  Yu F,  Lim KL."}},{"resource":"19741132","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","id":0,"type":"PUBMED","article":{"title":"Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.","authors":["Ng CH"," Mok SZ"," Koh C"," Ouyang X"," Fivaz ML"," Tan EK"," Dawson VL"," Dawson TM"," Yu F"," Lim KL."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","id":"19741132","citationCount":90,"stringAuthors":"Ng CH,  Mok SZ,  Koh C,  Ouyang X,  Fivaz ML,  Tan EK,  Dawson VL,  Dawson TM,  Yu F,  Lim KL."}}],"name":"PRKN","targetParticipants":[{"resource":"PRKN","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PRKN","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"20067578","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/20067578","id":0,"type":"PUBMED","article":{"title":"MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2.","authors":["Hsu CH"," Chan D"," Greggio E"," Saha S"," Guillily MD"," Ferree A"," Raghavan K"," Shen GC"," Segal L"," Ryu H"," Cookson MR"," Wolozin B."],"journal":"Journal of neurochemistry","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20067578","id":"20067578","citationCount":50,"stringAuthors":"Hsu CH,  Chan D,  Greggio E,  Saha S,  Guillily MD,  Ferree A,  Raghavan K,  Shen GC,  Segal L,  Ryu H,  Cookson MR,  Wolozin B."}},{"resource":"19692353","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/19692353","id":0,"type":"PUBMED","article":{"title":"Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease.","authors":["Venderova K"," Kabbach G"," Abdel-Messih E"," Zhang Y"," Parks RJ"," Imai Y"," Gehrke S"," Ngsee J"," Lavoie MJ"," Slack RS"," Rao Y"," Zhang Z"," Lu B"," Haque ME"," Park DS."],"journal":"Human molecular genetics","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19692353","id":"19692353","citationCount":78,"stringAuthors":"Venderova K,  Kabbach G,  Abdel-Messih E,  Zhang Y,  Parks RJ,  Imai Y,  Gehrke S,  Ngsee J,  Lavoie MJ,  Slack RS,  Rao Y,  Zhang Z,  Lu B,  Haque ME,  Park DS."}},{"resource":"18322385","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/18322385","id":0,"type":"PUBMED","article":{"title":"Investigating convergent actions of genes linked to familial Parkinson's disease.","authors":["Wolozin B"," Saha S"," Guillily M"," Ferree A"," Riley M."],"journal":"Neuro-degenerative diseases","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18322385","id":"18322385","citationCount":19,"stringAuthors":"Wolozin B,  Saha S,  Guillily M,  Ferree A,  Riley M."}},{"resource":"19625511","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/19625511","id":0,"type":"PUBMED","article":{"title":"LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans.","authors":["Saha S"," Guillily MD"," Ferree A"," Lanceta J"," Chan D"," Ghosh J"," Hsu CH"," Segal L"," Raghavan K"," Matsumoto K"," Hisamoto N"," Kuwahara T"," Iwatsubo T"," Moore L"," Goldstein L"," Cookson M"," Wolozin B."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19625511","id":"19625511","citationCount":97,"stringAuthors":"Saha S,  Guillily MD,  Ferree A,  Lanceta J,  Chan D,  Ghosh J,  Hsu CH,  Segal L,  Raghavan K,  Matsumoto K,  Hisamoto N,  Kuwahara T,  Iwatsubo T,  Moore L,  Goldstein L,  Cookson M,  Wolozin B."}},{"resource":"19741132","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","id":0,"type":"PUBMED","article":{"title":"Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.","authors":["Ng CH"," Mok SZ"," Koh C"," Ouyang X"," Fivaz ML"," Tan EK"," Dawson VL"," Dawson TM"," Yu F"," Lim KL."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","id":"19741132","citationCount":90,"stringAuthors":"Ng CH,  Mok SZ,  Koh C,  Ouyang X,  Fivaz ML,  Tan EK,  Dawson VL,  Dawson TM,  Yu F,  Lim KL."}}],"name":"LRRK2","targetParticipants":[{"resource":"LRRK2","annotatorClassName":"","descriptionByTypeRelation":"","descriptionByType":"","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LRRK2","id":0,"type":"HGNC_SYMBOL"}]}]}]
\ No newline at end of file