1. annotateBed. Annotates one BED/VCF/GFF file with the coverage and number of overlaps observed
from multiple other BED/VCF/GFF files. In this way, it allows one to ask to what degree one feature coincides with multiple other feature types with a single command. For example, the following will annotate the fraction of the variants in variants.bed that are covered by genes, conservaed regions and know variation, respectively.
This tool was suggested by Can Alkan and was motivated by the example source code that he kindly provided.
==New features==
1. New frequency operations (freqasc and freqdesc) added to groupBy. These operations report a histogram of the frequency that each value is observed in a given column.
2. Support for writing uncompressed bam with the -ubam option.
1. Increased the precision of the output from groupBy.
Version 2.9.0 (August-16-2010)
==New tools==
1. unionBedGraphs. This is a very powerful new tool contributed by Assaf Gordon from CSHL. It will combine/merge multiple BEDGRAPH files into a single file, thus allowing comparisons of coverage (or any text-value) across multiple samples.
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@@ -14,6 +40,8 @@ Version 2.9.1 (August-16-2010)
4. Fixed other minor parsing and reporting bugs/annoyances.
Version 2.8.3 (July-25-2010)
1. Fixed bug that caused some GFF files to be misinterpreted as VCF. This prevented the detection of overlaps.
2. Added a new "-tag" option in bamToBed that allows one to choose the _numeric_ tag that will be used to populate the score field. For example, one could populate the score field with the alignment score with "-tag AS".